www.neurodevnet.ca working together for healthy brains neurodevnet: opportunities in brain...
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www.neurodevnet.ca
WORKING TOGETHER FOR HEALTHY BRAINS
NeuroDevNet: Opportunities in Brain Development Across Canada
Dan Goldowitz, Scientific DirectorMarch 12, 2010
www.neurodevnet.ca
Overview of NeuroDevNet
NeuroDevNet is a Canadian Network of Centres of Excellence (NCE) in brain development, incorporated as a not-for-profit organization with seed funding by the government of Canada in December 2009.
NeuroDevNet’s mission is to:
Accelerate the pace of understanding the causes of
neurological deficits
Empower health care professionals, policy makers and
communities with new knowledge
Translate knowledge in to tangible diagnostic,
preventative, & therapeutic applications
Research and Training Knowledge Translation Business Development
www.neurodevnet.ca
Developing Brain
Understanding Brain Development
Preventio
n &
Treatment
Measurement &
Diagnosis
Knowledge Translation
Neuroinformatics
NeuroethicsSocietal Change
Scientific Discovery
Improvement in Clinical Practice and
Outcomes
Challenges to the Developing Brain &
Solutions
www.neurodevnet.ca
Imperative for a Canadian NCE in brain development
Leveraging Excellence Towards Solutions A network for the best and brightest in brain development in Canada,
bringing together the pockets of excellence in developmental brain research
Developing required infrastructure for Canada to be an international leader in Brain Development
The whole >> sum of parts
www.neurodevnet.ca
What NeuroDevNet is about:
We support synergies among a multidisciplinary community of experts throughout Canada in life and health sciences, social sciences, and computational and physical sciences to apply their collective expertise in the creation of new knowledge and solutions in brain development disorders
People
Our research and training is supported by 3 Cores in neuroethics, neuroinformatics and knowledge translation, along with expertise in imaging, animal models, genetics, and epigenetics, with emphasis on translational research
Infrastructure
We have access to cohort, registry and clinical databases across Canada and are expanding our access internationally, working with researchers from Singapore and Australia
Data Collection
Our neuroinformatics platform enables collaborative research between geographically dispersed groups and access to high-performance and distributed computing environments, algorithms and databases.
Data Analysis
We provide seed funding and support research projects with strong translational potential
Research Translation
www.neurodevnet.ca
Selection of Initial Research Projects
• Each disorder sheds light on the much larger spectrum of brain developmental disorders that affect Canadian children.
• Each disorder reflects roles of genes, environment, and GxE in brain function.
• Each disorder represents a significant socioeconomic burden to Canada.
• Our collective expertise across Canada will make major in-roads into understanding and treating each disorder.
• Three demonstration projects were selected (ASD, CP, and FASD) and an Opportunities Initiative.
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Costs to Society“When we fail to provide children with what they need to build a strong foundation for healthy and productive lives, we put our future prosperity and security at risk.”
(National Scientific Council on the Developing Child, 2007)
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British Columbia
Dr. S. Miller – University of British ColumbiaDr. U. Ribary – Simon Fraser University
British Columbia
Dr. S. Miller – University of British ColumbiaDr. U. Ribary – Simon Fraser University
Alberta
Dr. J. Yager – University of Alberta
Dr. B. Kolb & Dr. B. McNaugthon– University of Lethbridge
Alberta
Dr. J. Yager – University of Alberta
Dr. B. Kolb & Dr. B. McNaugthon– University of Lethbridge
Quebec
Dr. G. Rouleau Dr. M.-P. Dube – Université de Montréal
Dr. M. Szyf – McGill University
Quebec
Dr. G. Rouleau Dr. M.-P. Dube – Université de Montréal
Dr. M. Szyf – McGill University
QuebecDr. A. Evans – McGill UniversityDr. C. Limperopulous – McGill University
QuebecDr. A. Evans – McGill UniversityDr. C. Limperopulous – McGill University
British Columbia
Dr. M. Kobor – University of British Columbia
British Columbia
Dr. M. Kobor – University of British Columbia
AlbertaUniversity of AlbertaUniversity of CalgaryUniversity of Lethbridge
AlbertaUniversity of AlbertaUniversity of CalgaryUniversity of Lethbridge
Alberta
Dr. C. Beaulieu – University of Alberta
Alberta
Dr. C. Beaulieu – University of Alberta Ontario
University of Toronto
Queen’s University
McMaster University
York University
University of Western Ontario
Ontario
University of Toronto
Queen’s University
McMaster University
York University
University of Western Ontario
ManitobaUniversity of Manitoba
ManitobaUniversity of Manitoba
SaskatchewanUniversity of Saskatchewan
SaskatchewanUniversity of Saskatchewan
Ontario
Dr. R. Menon – University of Western Ontario
Ontario
Dr. R. Menon – University of Western Ontario
Ontario
Dr. B. Richardson – University of Western Ontario
Dr. M. Fehlings – University of Toronto
Ontario
Dr. B. Richardson – University of Western Ontario
Dr. M. Fehlings – University of Toronto
Nova ScotiaDalhousie University
Nova ScotiaDalhousie University
QuebecMcGill UniversityUniversité de Montréal
QuebecMcGill UniversityUniversité de Montréal
Administrative CentreAdministrative Centre
ImagingImagingGenetics/EpigeneticsGenetics/EpigeneticsAnimal ModelsAnimal Models
Ontario
Dr. S. Scherer – SickKids Hospital
Dr. A. Petronis – University of Toronto
Ontario
Dr. S. Scherer – SickKids Hospital
Dr. A. Petronis – University of TorontoBritish Columbia
Dr. J. Weinberger & Dr. D. Goldowitz – University of British Columbia
British Columbia
Dr. J. Weinberger & Dr. D. Goldowitz – University of British Columbia
British ColumbiaUniversity of British ColumbiaSimon Fraser University
British ColumbiaUniversity of British ColumbiaSimon Fraser University
A distributed network of excellence across Canada
www.neurodevnet.ca
The Net in NeuroDevNet
FamiliesCliniciansResearchersTraining ProgramsPolicy MakersProvincesIndustry
Australian CP RegistryNIMH, Autism SpeaksNIAAAINCF
ASD
FASD
CP
Trainees, Investigators, Committees, Advisory Groups, Platforms, Staff, Board, Children & Families
www.neurodevnet.ca
Overview of NeuroDevNet Infrastructure
• Create a research network of experts across Canada
• Support research projects in CP, Autism, and FASD
• Support opportunity funds
• Plan and organize annual meeting• Develop knowledge products and
tools• Expand relationships across
disciplinary boundaries
• Develop partnerships with industry
• Placement of trainees with industry• Provide projects start up funds
for commercialization opportunities
• Support trainee exchange programs• Conduct brain camps and co-
sponsor workshops• Offer trainee awards
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Cohort data collection Autism
Autism & Population Control Studies
Cell-based & Simple Model Organism Testing
Gene/Protein Network & Pathway Analysis
NeuroethicsNeuroethics
Knowledge Knowledge TranslationTranslation
Animal Animal ModelsModels
1 in 165 children in Canada have ASD.
1 autistic child = 3 Million societal cost over a lifetime
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A Trans-Canada Registry in Cerebral Palsy
Despite scientific progress, incidence remains 1-2 / thousand
1 CP child = 1.5Million societal cost over a lifetime
BC
Quebec
Alberta
NeuroDevNetPhenotypic, Epidemiological,
Genetic & Imaging Data
Clinical Trials
Pre-Clinical Studies
Best Practice
Genetics
Epigenetics
Animal Models
www.neurodevnet.ca
Clinical data collection Fetal Alcohol Spectrum Disorder
An estimated 9/1000 babies are born with FASD in Canada.
1 FASD child = 1-3 Million societal cost over a lifetime
26 clinics across North West Canada
FASD Clinic Cohort
Possible Mechanisms Underlying Neuro-behavioural Deficits
Basis for Development of Novel Interventions
Animal Models Studies
NeuroDevNetNeuro-psychological data, Circuitry data, Genetic and Epigenetic data
www.neurodevnet.ca
Vision for Training
• Trans-disciplinary scholars– Expose HQP to the full-spectrum of neurosciences
research incl. ethics, informatics, commercialization
• Team players– Enable HQP to establish and develop effective research
collaborations
• Translators– Equip HQP with skills to transfer research findings into
tangible health, social and economic benefits for Canadians
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Training Opportunities
• Canadian Child Health Clinician Scientist Program (CCHCSP)
• Autism Treatment Network (ART) with Autism Speaks
• Workshops, internships, travel, exchanges
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…with Canadian end users
• Family networks, advocacy
• Health service networks
• Provincial Ministries
• Links with credible websites
• Product placement
…with our trainees and investigators
• KT STIHR training program
• Media training, internships
• NCE scholarships
• Workshops:
• Writing for lay public
• IP & commercialization
…with all stakeholders
• Annual meeting
• Brainstorming
• Online interactions
Enhance KTEE…
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Impact of KTEE Efforts Innovation and acceleration of
scientific discoveries related to aberrant brain development
• A “learning community”• Interdisciplinary multi-method
research teams• Work with receptors
Commercialization of products and services
• Novel diagnostic tools• New treatments to optimize
outcomes
Building capacity of Canadian KTEE investigators in brain development
• Regional specialists within research teams
Improved the health of children with disabilities
• Earlier diagnosis• More effective treatments• Prevention of disability
NeuroDevNet is both a product and a catalyst of change
www.neurodevnet.ca
Dan Goldowitz, Scientific Director, NeuroDevNetSenior Scientist CMMT, CFRI, UBC604 875 3822 [email protected]
Nicky Lewis, Executive Director, [email protected]
Kevin McDuffie, Business Development Officer, [email protected]
NeuroDevNet Key Contacts
www.neurodevnet.ca
NeuroDevNetNeuroDevNet
Special thanks to Dawn McArthur, Joel Livingston and the RTDOThe Project Leads: Lonnie Zwaigenbaum (ASD), James Reynolds (FASD), andMichael Shevell (CP)The Core Leads: Paul Pavlidis (NI), Judy Illes (NE), and Nazeem Muhajarine (KT)
And to the heavy duty efforts of Anita Sham, Doug Swanson,Randy Glenn and the members of the Goldowitz lab who collated, sorted, proofed, reference checked, and drove cars.
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Questions?
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NeuroDevNet Research Operations
PROJECTSPROJECTS
COMMONCOMMONPLATFORMSPLATFORMS
Developing Brain
GeneticsGenetics
NeuroinformaticsNeuroinformatics
ImagingImaging
Animal ModelsAnimal Models
NeuroethicsNeuroethics
ASD CP FASD
INDIVIDUAL OUTCOMES & PRACTISE CHANGE
EVALUATION / METRICS
KNOWLEDGE TRANSFER & EXCHANGE
Opportunities
www.neurodevnet.ca
Partnership OpportunitiesDeveloping Brain
INDIVIDUAL OUTCOMES & PRACTICE CHANGE
Capacity Building
OTHER
Developing Brain
ASD CP FASD
Neuroethics
Neuroinformatics
Genetics and Epigenetics
Imaging
Animal Models
Knowledge Transfer
Business Development
• Partnership in other disease areas
• Partnership in imaging, animal models, genetics and epigenetics
• Expanding neuroInformatics platform
• Sponsoring trainees• Sponsoring specific workshops• Trainee placements
• Sponsoring specific KT activity• Joint development of KT
material
• Translational opportunities