wp1 progress report vienna, 13 march 2011
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WP1 Progress report Vienna, 13 March 2011. Achievements General. 4 Staff members (1 Image Analyst, 1 part-time Radiologist, 2 Research Assistants) in place Obtained approval from Medicines and Healthcare products Regulatory Agency - PowerPoint PPT PresentationTRANSCRIPT
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WP1 Progress report
Vienna, 13 March 2011
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AchievementsGeneral
- 4 Staff members (1 Image Analyst, 1 part-time Radiologist, 2 Research Assistants) in place
- Obtained approval from Medicines and Healthcare products Regulatory Agency
- Local Ethical Approval obtained provisionally, pending clarifications
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AchievementsStructural Imaging
1 Site survey ✔2 Site selection ✔3 Radiological and structural protocols (ADNI-GO) for 3T
scanners finalised and Manual sent to sites ✔4 Image Management System (TrialTracker) and electronic
data transfer tool (TrialWire) ✔
1 Sites to upload protocol and return protocol form in progress2 Sites to scan phantom and send details to IXICO in progress3 Sites to scan 1 healthy volunteer and send details to IXICO
not startedQualification and start scanning
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AchievementsStructural Imaging
3T SITESurvey
SentSurvey
ReceivedProtocol
SentProtocol Received
ACR Phantom at Site
ACR Phantom Scan Requested
ACR Phantom Scan Received
London Y Y Y Y Y Y YPrague Y Y Y Y Y Y YLeuven Y Y Y Y Y Y YUtrecht Y Y Y Y Y Y NMelbourne Y Y Y Y Y Y NCopenhagen Y Y Y Y Y Y NTel Aviv Y Y Y Y Y Y NMadrid Y Y Y Y N N NNaples Y Y Y N N N NBucharest Y Y Y N N N N
Innsbruck considering to join WP1
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AchievementsMagnetic Resonance Spectroscopy1 London, Copenhagen, Utrecht have met and agreed
protocol2 Spectra (anterior cingulate and thalamus) from
Copenhagen and Utrecht can be read and give reasonable values
3 The data can provide metabolite ratios4 Currently exploring whether we can do correction for
CSF in the MRS voxel which is a superior approach to the ratio method
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Milestones 1 Completion of preparation work for MRI sites
2 Start scanning
Deliverables1 Qualification of sites, test of electronic data transfer tool
2 Estimate of numbers (200 in total: if 10 sites, 20 patients per site)
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Possible concerns
Combination of MRS data:
- Existing power calculation did not take into account the greater variability of multicentre design
- Increase number of subjects with MRS at each site (~30-40 each: existing plan is for 20 subjects scanned twice in London and Copenhagen, so it would be slightly more than double)
- If datasets cannot be combined, we could explore whether findings are reproduced across sites
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Planned progress- Obtain final approval from local ethics- Qualify sites- Start recruitment and scanning- All sites to continue to scan phantom regularly plus 2
healthy volunteers (from the site) yearly, preferably every 6 months and before and after upgrades