why choose gastrointestinal testing?...user-friendly lab reports our gastrointestinal reports...

6
A comprehensive stool panel provides an ideal starting place for assessing gastrointestinal complaints. It offers the advantage of assessing multiple functional areas including digestive function, intestinal inflammation, and the intestinal microbiome, which may contribute to symptoms. Why Choose Gastrointestinal Testing? GI Effects ® Stool Profiles offer clinicians extensive insight into overall gut health while providing our most in-depth look into the microbiome. The GI Effects Comprehensive Stool Profile encompasses all of the elements of Genova stool profiles, assessing key functional areas of gut health including digestion and absorption, inflammation, bacteria and bacterial metabolism, yeast, and parasites. The GI Effects line includes PCR technology to measure 24 commensal bacteria and 6 protozoan parasites. 3-day or 1-day options available. GI Effects Comprehensive Stool Profile #2200 GI Effects Microbial Ecology Profile #2205 GI Effects Gut Pathogen Profile # 2207 CDSA 2.0 Profiles evaluate over 20 biomarkers in order to analyze digestion and absorption, inflammation, bacteria and bacterial metabolism, yeast, and parasites. CDSA 2.0 is available in New York State. · CDSA 2.0 ™ w/o Parasitology #2002 · CDSA/P 2.0™ #2003 · CDSA™ (Comprehensive Digestive Stool Analysis) # 2000 · CDSA/P™ (Comprehensive Digestive Stool Analysis with Parasitology.) # 2001 The Small Intestinal Bacterial Overgrowth Profile (SIBO) test assesses hydrogen and methane gases following ingestion of a lactulose solution. The SIBO test is a useful tool for patients with bloating, diarrhea, constipation, and gas. Available as a 2 or 3-hour collection. SIBO (Small Intestinal Bacterial Overgrowth) - 3 Hour # 2337 SIBO (Small Intestinal Bacterial Overgrowth) - 2 Hour # 2306 The Lactose Intolerance Breath Test assesses hydrogen and methane gases following ingestion of a lactose solution. The test is ideal for patients who experience digestive discomfort after consuming dairy. • Lactose Intolerance #2307 The Intestinal Permeability Assessment provides an evaluation of small intestinal absorption and barrier function using lactulose and mannitol. • Intestinal Permeability Assessment #2305 GASTROINTESTINAL Small Intestinal Bacterial Overgrowth (SIBO) BREATH URINE STOOL GASTROINTESTINAL Intestinal Permeability GASTROINTESTINAL Lactose Intolerance · Microbiology Analysis #2300 · Calprotectin #2308 · Giardia lamblia EIA #2312 · Yeast Culture with KOH Preparation #2301 · Cryptosporidium EIA #2309 · Gut Immunology #2313 · Parasitology #2302 · Eosinophil Protein X #2310 · H. pylori Stool Antigen HpSA #2314 · Comprehensive Parasitology Profile #2304 · Fecal Lactoferrin #2311 · Pancreatic Elastase #2315 Other Available Stool Profiles include:

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Page 1: Why Choose Gastrointestinal Testing?...User-Friendly Lab Reports Our gastrointestinal reports feature: • Actionable results related to flagged biomarkers and evaluations that allow

A comprehensive stool panel provides an ideal starting place for assessing gastrointestinal complaints It offers the advantage of assessing multiple functional areas including digestive function intestinal inflammation and the intestinal microbiome which may contribute to symptoms

Why Choose Gastrointestinal Testing

GI Effectsreg Stool Profiles offer clinicians extensive insight into overall gut health while providing our most in-depth look into the microbiome The GI Effects Comprehensive Stool Profile encompasses all of the elements of Genova stool profiles assessing key functional areas of gut health including digestion and absorption inflammation bacteria and bacterial metabolism yeast and parasites The GI Effects line includes PCR technology to measure 24 commensal bacteria and 6 protozoan parasites 3-day or 1-day options available

bull GI Effects Comprehensive Stool Profile 2200bull GI Effects Microbial Ecology Profile 2205bull GI Effects Gut Pathogen Profile 2207

CDSA 20 Profiles evaluate over 20 biomarkers in order to analyze digestion and absorption inflammation bacteria and bacterial metabolism yeast and parasites CDSA 20 is available in New York State

CDSA 20 trade wo Parasitology 2002 CDSAP 20trade 2003 CDSAtrade (Comprehensive Digestive Stool Analysis) 2000 CDSAPtrade (Comprehensive Digestive Stool Analysis with Parasitology) 2001

The Small Intestinal Bacterial Overgrowth Profile (SIBO) test assesses hydrogen and methane gases following ingestion of a lactulose solution The SIBO test is a useful tool for patients with bloating diarrhea constipation and gas Available as a 2 or 3-hour collectionbull SIBO (Small Intestinal Bacterial Overgrowth) - 3 Hour 2337bull SIBO (Small Intestinal Bacterial Overgrowth) - 2 Hour 2306

The Lactose Intolerance Breath Test assesses hydrogen and methane gases following ingestion of a lactose solution The test is ideal for patients who experience digestive discomfort after consuming dairy bull Lactose Intolerance 2307

The Intestinal Permeability Assessment provides an evaluation of small intestinal absorption and barrier function using lactulose and mannitol bull Intestinal Permeability Assessment 2305

GASTROINTESTINAL

Small IntestinalBacterial Overgrowth (SIBO)

B R E AT H

U R I N E

S TO O L

GASTROINTESTINALIntestinal Permeability

GASTROINTESTINALLactose Intolerance

Microbiology Analysis 2300 Calprotectin 2308 Giardia lamblia EIA 2312

Yeast Culture with KOH Preparation 2301 Cryptosporidium EIA 2309 Gut Immunology 2313

Parasitology 2302 Eosinophil Protein X 2310 H pylori Stool Antigen HpSA 2314

Comprehensive Parasitology Profile 2304 Fecal Lactoferrin 2311 Pancreatic Elastase 2315

Other Available Stool Profiles include

User-Friendly Lab Reports

Our gastrointestinal reports feature

bull Actionable results related to flagged biomarkers and evaluations that allow you to target personalized treatment plans

bull Color-metric reports that signal key areas of concern

bull Easy-to-use ldquoInterpretation At-A-Glancerdquo page that graphically depicts overarching results related to infection inflammation digestive insufficiency and health status of your patientsrsquo microbiome

Genova Diagnostics Inc63 Zillicoa Street

Asheville NC 28801Phone 8005224762

Fax 8282529303

w w w g d x n e t

Genova Diagnostics Europe46-50 Coombe Road

New MaldenSurrey KT3 4QF

Phone 02083367750Fax 02083367751

wwwgdxnetUK

GDX-7-151

copy 2 0 1 9 G e n o v a D i a g n o s t i c sgmpgastrointest inal_tr i fo ld 101519

Patient SAMPLEPATIENT

DOB Sex MRN

3425 Corporate WayDuluth GA 30096

2200 GI Effectstrade Comprehensive Profile - StoolInterpretation At-a-Glance

2200B

copy Genova Diagnostics middot Robert M David PhD Lab Director middot CLIA Lic 11D0255349 middot Medicare Lic 34-8475 middot Georgia Lab Lic Code 067-007 New York Clinical Lab PFI 4578 middot Florida Clinical Lab Lic 800008124

INFECTIONDientamoeba fragilis Blastocystis spp

INFLAMMATION

Calprotectin EPX

INSUFFICIENCY

Pancreatic Elastase 1 IMBALANCE

Beneficial Bacteria PP YeastFungi

RELATIVE ABUNDANCE

Bacteroidetes Phylum

Firmicutes Phylum

Verrucomicrobia Phylum

Fusobacteria Phylum

Euryarchaeota Phylum

Proteobacteria Phylum

Actinobacteria PhylumHEALTHYPATIENT

RESULTS COHORTA progressive ranking scale based on a Genova proprietary algorithm that differentiates healthy and unhealthy commensal patternsThe total number of Commensal Bacteria (PCR) that are out of reference ranges for this individual

See individual sections for detailed results

Gastrointestinal Testing Physician Line Guide Advanced Diagnostics for Gut Health and Treating Complex Diseases

Insights from Genova Diagnosticsrsquo gastrointestinal line of testing may help reveal hidden causes of digestive discomfort so you can personalize patient recommendations

IND

IVID

UA

L C

OM

PO

NE

NT

SBIOMARKERS REPORTED

GI EffectsComp

2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Not Available in New York - Biomarkers with product numbers are available as stand-alone tests

DigestionAbsorption

Pancreatic Elastase 1 bull + + bull bull

Chymotrypsin bull bull + +

Putrefactive SCFA Products of Protein Breakdown (Total) (ValerateIsobutyrateIsovalerate) bull bull bull bull bull

Meat Fibers bull bull

Vegetable Fibers bull bull

Fecal Fat (Total) bull bull bull + +

Long Chain Fatty Acids bull bull bull + +

Triglycerides bull bull bull + +

Phospholipids bull bull bull + +

Cholesterol bull bull bull + +

Gut Immunology

Calprotectin bull + + bull bull

Eosinophil Protein X (EPX) bull + + bull bull

Fecal sIgA bull

Metabolic

SCFA (Total) (Acetate n-Butyrate Propionate) bull bull bull bull bull

n-Butyrate Concentration bull bull bull bull bull

pH bull bull bull bull

SCFA Distribution bull bull bull + +

n-Butyrate bull bull bull + +

Acetate bull bull bull + +

Propionate bull bull bull + +

Beta-glucuronidase bull bull bull bull bull

Secondary Bile Acids Lithocholic Acid Deoxycholic Acid + + bull bull

Inflammation

Fecal Lactoferrin (2311) + + bull bull

Mucus bull bull

Gastrointestinal Microbiome

Commensal Bacteria (PCR)

Bacteroidetes Phylum bull bull

Bacteroides-Prevotella group bull bull

Bacteroides vulgatus bull bull

Barnesiella spp bull bull

Odoribacter spp bull bull

Prevotella spp bull bull

Firmicutes Phylum bull bull

Anaerotruncus colihominis bull bull

Butyrivibrio crossotus bull bull

Clostridium spp bull bull

Coprococcus eutactus bull bull

Faecalibacterium prausnitzii bull bull

Lactobacillus spp bull bull

Pseudoflavonifractor spp bull bull

Roseburia spp bull bull

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Commensal Bacteria (PCR)

Ruminococcus spp bull bull

Veillonella spp bull bull

Actinobacteria Phylum bull bull

Bifidobacterium spp bull bull

Bifidobacterium longum bull bull

Collinsella aerofaciens bull bull

Proteobacteria Phylum bull bull

Desulfovibrio piger bull bull

Escherichia coli bull bull

Oxalobacter formigenes bull bull

Euryarchaeota Phylum bull bull

Methanobrevibacter smithii bull bull

Fusobacteria Phylum bull bull

Fusobacterium spp bull bull

Verrucomicrobia Phylum bull bull

Akkermansia muciniphila bull bull

FirmicutesBacteroidetes (FB Ratio) bull bull

Bacteriology and Mycology

Lactobacillus spp bull bull bull bull bull bull bull

Escherichia coli bull bull bull bull bull bull bull

Bifidobacterium spp bull bull bull bull bull bull bull

Additional Bacteria Citrobacter sp Klebsiella pneumoniae Proteus mirabilis Salmonella sp Enterococcus sp etc bull bull bull bull bull bull bull

Mycology (YeastFungi) Candida albicans Candida krusei Candida parapsilosis Rhodotorula sp Saccharomyces etc bull bull bull bull bull bull bull

Parasitology

Microscopic Exam Results (a comprehensive evaluation for ova and parasites) bull bull bull bull bull

Parasitology EIA Tests (Giardia spp Cryptosporidium Entamoeba Histolytica) bull bull

Nematodes - roundworms

Acylostoma duodenale (Hookworm) bull bull bull bull bull

Ascaris lumbricoides bull bull bull bull bull

Capillaria philippinensis bull bull bull bull bull

Enterobius vermicularis bull bull bull bull bull

Necator americanus (Hookworm) bull bull bull bull bull

Strongyloides stercoralis bull bull bull bull bull

Trichuris trichiura bull bull bull bull bull

Cestodes-tapeworms

Diphyllobothrium latum bull bull bull bull bull

Dipylidium caninum bull bull bull bull bull

Hymenolepis diminuta bull bull bull bull bull

Hymenolepis nana bull bull bull bull bull

Taenia spp bull bull bull bull bull

Trematodes-flukes

ClonorchisOpisthorchis spp bull bull bull bull bull

Fasciola sppFasciolopsis buski ova bull bull bull bull bull

HeterophyesMetagonimus ova bull bull bull bull bull

Paragonimus spp bull bull bull bull bull

Schistosoma spp bull bull bull bull bull

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Parasitology

Protozoa

Balantidium coli bull bull bull bull bull

Blastocystis spp bull bull bull bull bull

Chilomastix mesnili bull bull bull bull bull

Cryptosporidium spp bull bull bull bull bull

Cyclospora cayetanensis bull bull bull bull bull

Dientamoeba fragilis bull bull bull bull bull

Entamoeba coli bull bull bull bull bull

Entamoeba dispar bull bull bull bull bull

Entamoeba hartmanni bull bull bull bull bull

Entamoeba histolytica bull bull bull bull bull

Entamoeba polecki bull bull bull bull bull

Endolimax nana bull bull bull bull bull

Giardia bull bull bull bull bull

Iodamoeba butschlii bull bull bull bull bull

Isospora spp bull bull bull bull bull

Trichomonads (eg Pentatrichomonas) bull bull bull bull bull

PCR Parasitology - Protozoa

Blastocystis spp bull bull bull

Cryptosporidium spp bull bull bull

Cyclospora cayetanensis bull bull bull

Dientamoeba fragilis bull bull bull

Entamoeba histolytica bull bull bull

Giardia bull bull bull

Blastocystis spp Reflex Subtyping (Types 1 - 9) bull bull bull

Bacterial Sensitivties (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Mycology Sensitivities (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Additional Findings

Fecal Occult Blood bull bull bull + +

Color bull bull bull bull

Consistency bull bull

Add-on Testing

Campylobacter EIA + + + + + + +

Chymotrypsin + +

Clostridium difficile EIA + + + + + + +

Helicobacter pylori Stool Antigen EIA + + + + + + +

KOH Preparation for Yeast + + bull

MacrospcopicDirect Examination for Parasites + + bull + + + +

Secondary Bile Acids Lithocholic Acid Deoxycholic Acid + +

Shiga-like Toxin Escherichia coli EIA + + + + + + +

Zonulin Family Peptide Stool + + +

Page 2: Why Choose Gastrointestinal Testing?...User-Friendly Lab Reports Our gastrointestinal reports feature: • Actionable results related to flagged biomarkers and evaluations that allow

User-Friendly Lab Reports

Our gastrointestinal reports feature

bull Actionable results related to flagged biomarkers and evaluations that allow you to target personalized treatment plans

bull Color-metric reports that signal key areas of concern

bull Easy-to-use ldquoInterpretation At-A-Glancerdquo page that graphically depicts overarching results related to infection inflammation digestive insufficiency and health status of your patientsrsquo microbiome

Genova Diagnostics Inc63 Zillicoa Street

Asheville NC 28801Phone 8005224762

Fax 8282529303

w w w g d x n e t

Genova Diagnostics Europe46-50 Coombe Road

New MaldenSurrey KT3 4QF

Phone 02083367750Fax 02083367751

wwwgdxnetUK

GDX-7-151

copy 2 0 1 9 G e n o v a D i a g n o s t i c sgmpgastrointest inal_tr i fo ld 101519

Patient SAMPLEPATIENT

DOB Sex MRN

3425 Corporate WayDuluth GA 30096

2200 GI Effectstrade Comprehensive Profile - StoolInterpretation At-a-Glance

2200B

copy Genova Diagnostics middot Robert M David PhD Lab Director middot CLIA Lic 11D0255349 middot Medicare Lic 34-8475 middot Georgia Lab Lic Code 067-007 New York Clinical Lab PFI 4578 middot Florida Clinical Lab Lic 800008124

INFECTIONDientamoeba fragilis Blastocystis spp

INFLAMMATION

Calprotectin EPX

INSUFFICIENCY

Pancreatic Elastase 1 IMBALANCE

Beneficial Bacteria PP YeastFungi

RELATIVE ABUNDANCE

Bacteroidetes Phylum

Firmicutes Phylum

Verrucomicrobia Phylum

Fusobacteria Phylum

Euryarchaeota Phylum

Proteobacteria Phylum

Actinobacteria PhylumHEALTHYPATIENT

RESULTS COHORTA progressive ranking scale based on a Genova proprietary algorithm that differentiates healthy and unhealthy commensal patternsThe total number of Commensal Bacteria (PCR) that are out of reference ranges for this individual

See individual sections for detailed results

Gastrointestinal Testing Physician Line Guide Advanced Diagnostics for Gut Health and Treating Complex Diseases

Insights from Genova Diagnosticsrsquo gastrointestinal line of testing may help reveal hidden causes of digestive discomfort so you can personalize patient recommendations

IND

IVID

UA

L C

OM

PO

NE

NT

SBIOMARKERS REPORTED

GI EffectsComp

2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Not Available in New York - Biomarkers with product numbers are available as stand-alone tests

DigestionAbsorption

Pancreatic Elastase 1 bull + + bull bull

Chymotrypsin bull bull + +

Putrefactive SCFA Products of Protein Breakdown (Total) (ValerateIsobutyrateIsovalerate) bull bull bull bull bull

Meat Fibers bull bull

Vegetable Fibers bull bull

Fecal Fat (Total) bull bull bull + +

Long Chain Fatty Acids bull bull bull + +

Triglycerides bull bull bull + +

Phospholipids bull bull bull + +

Cholesterol bull bull bull + +

Gut Immunology

Calprotectin bull + + bull bull

Eosinophil Protein X (EPX) bull + + bull bull

Fecal sIgA bull

Metabolic

SCFA (Total) (Acetate n-Butyrate Propionate) bull bull bull bull bull

n-Butyrate Concentration bull bull bull bull bull

pH bull bull bull bull

SCFA Distribution bull bull bull + +

n-Butyrate bull bull bull + +

Acetate bull bull bull + +

Propionate bull bull bull + +

Beta-glucuronidase bull bull bull bull bull

Secondary Bile Acids Lithocholic Acid Deoxycholic Acid + + bull bull

Inflammation

Fecal Lactoferrin (2311) + + bull bull

Mucus bull bull

Gastrointestinal Microbiome

Commensal Bacteria (PCR)

Bacteroidetes Phylum bull bull

Bacteroides-Prevotella group bull bull

Bacteroides vulgatus bull bull

Barnesiella spp bull bull

Odoribacter spp bull bull

Prevotella spp bull bull

Firmicutes Phylum bull bull

Anaerotruncus colihominis bull bull

Butyrivibrio crossotus bull bull

Clostridium spp bull bull

Coprococcus eutactus bull bull

Faecalibacterium prausnitzii bull bull

Lactobacillus spp bull bull

Pseudoflavonifractor spp bull bull

Roseburia spp bull bull

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Commensal Bacteria (PCR)

Ruminococcus spp bull bull

Veillonella spp bull bull

Actinobacteria Phylum bull bull

Bifidobacterium spp bull bull

Bifidobacterium longum bull bull

Collinsella aerofaciens bull bull

Proteobacteria Phylum bull bull

Desulfovibrio piger bull bull

Escherichia coli bull bull

Oxalobacter formigenes bull bull

Euryarchaeota Phylum bull bull

Methanobrevibacter smithii bull bull

Fusobacteria Phylum bull bull

Fusobacterium spp bull bull

Verrucomicrobia Phylum bull bull

Akkermansia muciniphila bull bull

FirmicutesBacteroidetes (FB Ratio) bull bull

Bacteriology and Mycology

Lactobacillus spp bull bull bull bull bull bull bull

Escherichia coli bull bull bull bull bull bull bull

Bifidobacterium spp bull bull bull bull bull bull bull

Additional Bacteria Citrobacter sp Klebsiella pneumoniae Proteus mirabilis Salmonella sp Enterococcus sp etc bull bull bull bull bull bull bull

Mycology (YeastFungi) Candida albicans Candida krusei Candida parapsilosis Rhodotorula sp Saccharomyces etc bull bull bull bull bull bull bull

Parasitology

Microscopic Exam Results (a comprehensive evaluation for ova and parasites) bull bull bull bull bull

Parasitology EIA Tests (Giardia spp Cryptosporidium Entamoeba Histolytica) bull bull

Nematodes - roundworms

Acylostoma duodenale (Hookworm) bull bull bull bull bull

Ascaris lumbricoides bull bull bull bull bull

Capillaria philippinensis bull bull bull bull bull

Enterobius vermicularis bull bull bull bull bull

Necator americanus (Hookworm) bull bull bull bull bull

Strongyloides stercoralis bull bull bull bull bull

Trichuris trichiura bull bull bull bull bull

Cestodes-tapeworms

Diphyllobothrium latum bull bull bull bull bull

Dipylidium caninum bull bull bull bull bull

Hymenolepis diminuta bull bull bull bull bull

Hymenolepis nana bull bull bull bull bull

Taenia spp bull bull bull bull bull

Trematodes-flukes

ClonorchisOpisthorchis spp bull bull bull bull bull

Fasciola sppFasciolopsis buski ova bull bull bull bull bull

HeterophyesMetagonimus ova bull bull bull bull bull

Paragonimus spp bull bull bull bull bull

Schistosoma spp bull bull bull bull bull

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Parasitology

Protozoa

Balantidium coli bull bull bull bull bull

Blastocystis spp bull bull bull bull bull

Chilomastix mesnili bull bull bull bull bull

Cryptosporidium spp bull bull bull bull bull

Cyclospora cayetanensis bull bull bull bull bull

Dientamoeba fragilis bull bull bull bull bull

Entamoeba coli bull bull bull bull bull

Entamoeba dispar bull bull bull bull bull

Entamoeba hartmanni bull bull bull bull bull

Entamoeba histolytica bull bull bull bull bull

Entamoeba polecki bull bull bull bull bull

Endolimax nana bull bull bull bull bull

Giardia bull bull bull bull bull

Iodamoeba butschlii bull bull bull bull bull

Isospora spp bull bull bull bull bull

Trichomonads (eg Pentatrichomonas) bull bull bull bull bull

PCR Parasitology - Protozoa

Blastocystis spp bull bull bull

Cryptosporidium spp bull bull bull

Cyclospora cayetanensis bull bull bull

Dientamoeba fragilis bull bull bull

Entamoeba histolytica bull bull bull

Giardia bull bull bull

Blastocystis spp Reflex Subtyping (Types 1 - 9) bull bull bull

Bacterial Sensitivties (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Mycology Sensitivities (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Additional Findings

Fecal Occult Blood bull bull bull + +

Color bull bull bull bull

Consistency bull bull

Add-on Testing

Campylobacter EIA + + + + + + +

Chymotrypsin + +

Clostridium difficile EIA + + + + + + +

Helicobacter pylori Stool Antigen EIA + + + + + + +

KOH Preparation for Yeast + + bull

MacrospcopicDirect Examination for Parasites + + bull + + + +

Secondary Bile Acids Lithocholic Acid Deoxycholic Acid + +

Shiga-like Toxin Escherichia coli EIA + + + + + + +

Zonulin Family Peptide Stool + + +

Page 3: Why Choose Gastrointestinal Testing?...User-Friendly Lab Reports Our gastrointestinal reports feature: • Actionable results related to flagged biomarkers and evaluations that allow

Gastrointestinal Testing Physician Line Guide Advanced Diagnostics for Gut Health and Treating Complex Diseases

Insights from Genova Diagnosticsrsquo gastrointestinal line of testing may help reveal hidden causes of digestive discomfort so you can personalize patient recommendations

IND

IVID

UA

L C

OM

PO

NE

NT

SBIOMARKERS REPORTED

GI EffectsComp

2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Not Available in New York - Biomarkers with product numbers are available as stand-alone tests

DigestionAbsorption

Pancreatic Elastase 1 bull + + bull bull

Chymotrypsin bull bull + +

Putrefactive SCFA Products of Protein Breakdown (Total) (ValerateIsobutyrateIsovalerate) bull bull bull bull bull

Meat Fibers bull bull

Vegetable Fibers bull bull

Fecal Fat (Total) bull bull bull + +

Long Chain Fatty Acids bull bull bull + +

Triglycerides bull bull bull + +

Phospholipids bull bull bull + +

Cholesterol bull bull bull + +

Gut Immunology

Calprotectin bull + + bull bull

Eosinophil Protein X (EPX) bull + + bull bull

Fecal sIgA bull

Metabolic

SCFA (Total) (Acetate n-Butyrate Propionate) bull bull bull bull bull

n-Butyrate Concentration bull bull bull bull bull

pH bull bull bull bull

SCFA Distribution bull bull bull + +

n-Butyrate bull bull bull + +

Acetate bull bull bull + +

Propionate bull bull bull + +

Beta-glucuronidase bull bull bull bull bull

Secondary Bile Acids Lithocholic Acid Deoxycholic Acid + + bull bull

Inflammation

Fecal Lactoferrin (2311) + + bull bull

Mucus bull bull

Gastrointestinal Microbiome

Commensal Bacteria (PCR)

Bacteroidetes Phylum bull bull

Bacteroides-Prevotella group bull bull

Bacteroides vulgatus bull bull

Barnesiella spp bull bull

Odoribacter spp bull bull

Prevotella spp bull bull

Firmicutes Phylum bull bull

Anaerotruncus colihominis bull bull

Butyrivibrio crossotus bull bull

Clostridium spp bull bull

Coprococcus eutactus bull bull

Faecalibacterium prausnitzii bull bull

Lactobacillus spp bull bull

Pseudoflavonifractor spp bull bull

Roseburia spp bull bull

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Commensal Bacteria (PCR)

Ruminococcus spp bull bull

Veillonella spp bull bull

Actinobacteria Phylum bull bull

Bifidobacterium spp bull bull

Bifidobacterium longum bull bull

Collinsella aerofaciens bull bull

Proteobacteria Phylum bull bull

Desulfovibrio piger bull bull

Escherichia coli bull bull

Oxalobacter formigenes bull bull

Euryarchaeota Phylum bull bull

Methanobrevibacter smithii bull bull

Fusobacteria Phylum bull bull

Fusobacterium spp bull bull

Verrucomicrobia Phylum bull bull

Akkermansia muciniphila bull bull

FirmicutesBacteroidetes (FB Ratio) bull bull

Bacteriology and Mycology

Lactobacillus spp bull bull bull bull bull bull bull

Escherichia coli bull bull bull bull bull bull bull

Bifidobacterium spp bull bull bull bull bull bull bull

Additional Bacteria Citrobacter sp Klebsiella pneumoniae Proteus mirabilis Salmonella sp Enterococcus sp etc bull bull bull bull bull bull bull

Mycology (YeastFungi) Candida albicans Candida krusei Candida parapsilosis Rhodotorula sp Saccharomyces etc bull bull bull bull bull bull bull

Parasitology

Microscopic Exam Results (a comprehensive evaluation for ova and parasites) bull bull bull bull bull

Parasitology EIA Tests (Giardia spp Cryptosporidium Entamoeba Histolytica) bull bull

Nematodes - roundworms

Acylostoma duodenale (Hookworm) bull bull bull bull bull

Ascaris lumbricoides bull bull bull bull bull

Capillaria philippinensis bull bull bull bull bull

Enterobius vermicularis bull bull bull bull bull

Necator americanus (Hookworm) bull bull bull bull bull

Strongyloides stercoralis bull bull bull bull bull

Trichuris trichiura bull bull bull bull bull

Cestodes-tapeworms

Diphyllobothrium latum bull bull bull bull bull

Dipylidium caninum bull bull bull bull bull

Hymenolepis diminuta bull bull bull bull bull

Hymenolepis nana bull bull bull bull bull

Taenia spp bull bull bull bull bull

Trematodes-flukes

ClonorchisOpisthorchis spp bull bull bull bull bull

Fasciola sppFasciolopsis buski ova bull bull bull bull bull

HeterophyesMetagonimus ova bull bull bull bull bull

Paragonimus spp bull bull bull bull bull

Schistosoma spp bull bull bull bull bull

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Parasitology

Protozoa

Balantidium coli bull bull bull bull bull

Blastocystis spp bull bull bull bull bull

Chilomastix mesnili bull bull bull bull bull

Cryptosporidium spp bull bull bull bull bull

Cyclospora cayetanensis bull bull bull bull bull

Dientamoeba fragilis bull bull bull bull bull

Entamoeba coli bull bull bull bull bull

Entamoeba dispar bull bull bull bull bull

Entamoeba hartmanni bull bull bull bull bull

Entamoeba histolytica bull bull bull bull bull

Entamoeba polecki bull bull bull bull bull

Endolimax nana bull bull bull bull bull

Giardia bull bull bull bull bull

Iodamoeba butschlii bull bull bull bull bull

Isospora spp bull bull bull bull bull

Trichomonads (eg Pentatrichomonas) bull bull bull bull bull

PCR Parasitology - Protozoa

Blastocystis spp bull bull bull

Cryptosporidium spp bull bull bull

Cyclospora cayetanensis bull bull bull

Dientamoeba fragilis bull bull bull

Entamoeba histolytica bull bull bull

Giardia bull bull bull

Blastocystis spp Reflex Subtyping (Types 1 - 9) bull bull bull

Bacterial Sensitivties (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Mycology Sensitivities (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Additional Findings

Fecal Occult Blood bull bull bull + +

Color bull bull bull bull

Consistency bull bull

Add-on Testing

Campylobacter EIA + + + + + + +

Chymotrypsin + +

Clostridium difficile EIA + + + + + + +

Helicobacter pylori Stool Antigen EIA + + + + + + +

KOH Preparation for Yeast + + bull

MacrospcopicDirect Examination for Parasites + + bull + + + +

Secondary Bile Acids Lithocholic Acid Deoxycholic Acid + +

Shiga-like Toxin Escherichia coli EIA + + + + + + +

Zonulin Family Peptide Stool + + +

Page 4: Why Choose Gastrointestinal Testing?...User-Friendly Lab Reports Our gastrointestinal reports feature: • Actionable results related to flagged biomarkers and evaluations that allow

IND

IVID

UA

L C

OM

PO

NE

NT

SBIOMARKERS REPORTED

GI EffectsComp

2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Not Available in New York - Biomarkers with product numbers are available as stand-alone tests

DigestionAbsorption

Pancreatic Elastase 1 bull + + bull bull

Chymotrypsin bull bull + +

Putrefactive SCFA Products of Protein Breakdown (Total) (ValerateIsobutyrateIsovalerate) bull bull bull bull bull

Meat Fibers bull bull

Vegetable Fibers bull bull

Fecal Fat (Total) bull bull bull + +

Long Chain Fatty Acids bull bull bull + +

Triglycerides bull bull bull + +

Phospholipids bull bull bull + +

Cholesterol bull bull bull + +

Gut Immunology

Calprotectin bull + + bull bull

Eosinophil Protein X (EPX) bull + + bull bull

Fecal sIgA bull

Metabolic

SCFA (Total) (Acetate n-Butyrate Propionate) bull bull bull bull bull

n-Butyrate Concentration bull bull bull bull bull

pH bull bull bull bull

SCFA Distribution bull bull bull + +

n-Butyrate bull bull bull + +

Acetate bull bull bull + +

Propionate bull bull bull + +

Beta-glucuronidase bull bull bull bull bull

Secondary Bile Acids Lithocholic Acid Deoxycholic Acid + + bull bull

Inflammation

Fecal Lactoferrin (2311) + + bull bull

Mucus bull bull

Gastrointestinal Microbiome

Commensal Bacteria (PCR)

Bacteroidetes Phylum bull bull

Bacteroides-Prevotella group bull bull

Bacteroides vulgatus bull bull

Barnesiella spp bull bull

Odoribacter spp bull bull

Prevotella spp bull bull

Firmicutes Phylum bull bull

Anaerotruncus colihominis bull bull

Butyrivibrio crossotus bull bull

Clostridium spp bull bull

Coprococcus eutactus bull bull

Faecalibacterium prausnitzii bull bull

Lactobacillus spp bull bull

Pseudoflavonifractor spp bull bull

Roseburia spp bull bull

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Commensal Bacteria (PCR)

Ruminococcus spp bull bull

Veillonella spp bull bull

Actinobacteria Phylum bull bull

Bifidobacterium spp bull bull

Bifidobacterium longum bull bull

Collinsella aerofaciens bull bull

Proteobacteria Phylum bull bull

Desulfovibrio piger bull bull

Escherichia coli bull bull

Oxalobacter formigenes bull bull

Euryarchaeota Phylum bull bull

Methanobrevibacter smithii bull bull

Fusobacteria Phylum bull bull

Fusobacterium spp bull bull

Verrucomicrobia Phylum bull bull

Akkermansia muciniphila bull bull

FirmicutesBacteroidetes (FB Ratio) bull bull

Bacteriology and Mycology

Lactobacillus spp bull bull bull bull bull bull bull

Escherichia coli bull bull bull bull bull bull bull

Bifidobacterium spp bull bull bull bull bull bull bull

Additional Bacteria Citrobacter sp Klebsiella pneumoniae Proteus mirabilis Salmonella sp Enterococcus sp etc bull bull bull bull bull bull bull

Mycology (YeastFungi) Candida albicans Candida krusei Candida parapsilosis Rhodotorula sp Saccharomyces etc bull bull bull bull bull bull bull

Parasitology

Microscopic Exam Results (a comprehensive evaluation for ova and parasites) bull bull bull bull bull

Parasitology EIA Tests (Giardia spp Cryptosporidium Entamoeba Histolytica) bull bull

Nematodes - roundworms

Acylostoma duodenale (Hookworm) bull bull bull bull bull

Ascaris lumbricoides bull bull bull bull bull

Capillaria philippinensis bull bull bull bull bull

Enterobius vermicularis bull bull bull bull bull

Necator americanus (Hookworm) bull bull bull bull bull

Strongyloides stercoralis bull bull bull bull bull

Trichuris trichiura bull bull bull bull bull

Cestodes-tapeworms

Diphyllobothrium latum bull bull bull bull bull

Dipylidium caninum bull bull bull bull bull

Hymenolepis diminuta bull bull bull bull bull

Hymenolepis nana bull bull bull bull bull

Taenia spp bull bull bull bull bull

Trematodes-flukes

ClonorchisOpisthorchis spp bull bull bull bull bull

Fasciola sppFasciolopsis buski ova bull bull bull bull bull

HeterophyesMetagonimus ova bull bull bull bull bull

Paragonimus spp bull bull bull bull bull

Schistosoma spp bull bull bull bull bull

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Parasitology

Protozoa

Balantidium coli bull bull bull bull bull

Blastocystis spp bull bull bull bull bull

Chilomastix mesnili bull bull bull bull bull

Cryptosporidium spp bull bull bull bull bull

Cyclospora cayetanensis bull bull bull bull bull

Dientamoeba fragilis bull bull bull bull bull

Entamoeba coli bull bull bull bull bull

Entamoeba dispar bull bull bull bull bull

Entamoeba hartmanni bull bull bull bull bull

Entamoeba histolytica bull bull bull bull bull

Entamoeba polecki bull bull bull bull bull

Endolimax nana bull bull bull bull bull

Giardia bull bull bull bull bull

Iodamoeba butschlii bull bull bull bull bull

Isospora spp bull bull bull bull bull

Trichomonads (eg Pentatrichomonas) bull bull bull bull bull

PCR Parasitology - Protozoa

Blastocystis spp bull bull bull

Cryptosporidium spp bull bull bull

Cyclospora cayetanensis bull bull bull

Dientamoeba fragilis bull bull bull

Entamoeba histolytica bull bull bull

Giardia bull bull bull

Blastocystis spp Reflex Subtyping (Types 1 - 9) bull bull bull

Bacterial Sensitivties (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Mycology Sensitivities (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Additional Findings

Fecal Occult Blood bull bull bull + +

Color bull bull bull bull

Consistency bull bull

Add-on Testing

Campylobacter EIA + + + + + + +

Chymotrypsin + +

Clostridium difficile EIA + + + + + + +

Helicobacter pylori Stool Antigen EIA + + + + + + +

KOH Preparation for Yeast + + bull

MacrospcopicDirect Examination for Parasites + + bull + + + +

Secondary Bile Acids Lithocholic Acid Deoxycholic Acid + +

Shiga-like Toxin Escherichia coli EIA + + + + + + +

Zonulin Family Peptide Stool + + +

Page 5: Why Choose Gastrointestinal Testing?...User-Friendly Lab Reports Our gastrointestinal reports feature: • Actionable results related to flagged biomarkers and evaluations that allow

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Commensal Bacteria (PCR)

Ruminococcus spp bull bull

Veillonella spp bull bull

Actinobacteria Phylum bull bull

Bifidobacterium spp bull bull

Bifidobacterium longum bull bull

Collinsella aerofaciens bull bull

Proteobacteria Phylum bull bull

Desulfovibrio piger bull bull

Escherichia coli bull bull

Oxalobacter formigenes bull bull

Euryarchaeota Phylum bull bull

Methanobrevibacter smithii bull bull

Fusobacteria Phylum bull bull

Fusobacterium spp bull bull

Verrucomicrobia Phylum bull bull

Akkermansia muciniphila bull bull

FirmicutesBacteroidetes (FB Ratio) bull bull

Bacteriology and Mycology

Lactobacillus spp bull bull bull bull bull bull bull

Escherichia coli bull bull bull bull bull bull bull

Bifidobacterium spp bull bull bull bull bull bull bull

Additional Bacteria Citrobacter sp Klebsiella pneumoniae Proteus mirabilis Salmonella sp Enterococcus sp etc bull bull bull bull bull bull bull

Mycology (YeastFungi) Candida albicans Candida krusei Candida parapsilosis Rhodotorula sp Saccharomyces etc bull bull bull bull bull bull bull

Parasitology

Microscopic Exam Results (a comprehensive evaluation for ova and parasites) bull bull bull bull bull

Parasitology EIA Tests (Giardia spp Cryptosporidium Entamoeba Histolytica) bull bull

Nematodes - roundworms

Acylostoma duodenale (Hookworm) bull bull bull bull bull

Ascaris lumbricoides bull bull bull bull bull

Capillaria philippinensis bull bull bull bull bull

Enterobius vermicularis bull bull bull bull bull

Necator americanus (Hookworm) bull bull bull bull bull

Strongyloides stercoralis bull bull bull bull bull

Trichuris trichiura bull bull bull bull bull

Cestodes-tapeworms

Diphyllobothrium latum bull bull bull bull bull

Dipylidium caninum bull bull bull bull bull

Hymenolepis diminuta bull bull bull bull bull

Hymenolepis nana bull bull bull bull bull

Taenia spp bull bull bull bull bull

Trematodes-flukes

ClonorchisOpisthorchis spp bull bull bull bull bull

Fasciola sppFasciolopsis buski ova bull bull bull bull bull

HeterophyesMetagonimus ova bull bull bull bull bull

Paragonimus spp bull bull bull bull bull

Schistosoma spp bull bull bull bull bull

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Parasitology

Protozoa

Balantidium coli bull bull bull bull bull

Blastocystis spp bull bull bull bull bull

Chilomastix mesnili bull bull bull bull bull

Cryptosporidium spp bull bull bull bull bull

Cyclospora cayetanensis bull bull bull bull bull

Dientamoeba fragilis bull bull bull bull bull

Entamoeba coli bull bull bull bull bull

Entamoeba dispar bull bull bull bull bull

Entamoeba hartmanni bull bull bull bull bull

Entamoeba histolytica bull bull bull bull bull

Entamoeba polecki bull bull bull bull bull

Endolimax nana bull bull bull bull bull

Giardia bull bull bull bull bull

Iodamoeba butschlii bull bull bull bull bull

Isospora spp bull bull bull bull bull

Trichomonads (eg Pentatrichomonas) bull bull bull bull bull

PCR Parasitology - Protozoa

Blastocystis spp bull bull bull

Cryptosporidium spp bull bull bull

Cyclospora cayetanensis bull bull bull

Dientamoeba fragilis bull bull bull

Entamoeba histolytica bull bull bull

Giardia bull bull bull

Blastocystis spp Reflex Subtyping (Types 1 - 9) bull bull bull

Bacterial Sensitivties (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Mycology Sensitivities (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Additional Findings

Fecal Occult Blood bull bull bull + +

Color bull bull bull bull

Consistency bull bull

Add-on Testing

Campylobacter EIA + + + + + + +

Chymotrypsin + +

Clostridium difficile EIA + + + + + + +

Helicobacter pylori Stool Antigen EIA + + + + + + +

KOH Preparation for Yeast + + bull

MacrospcopicDirect Examination for Parasites + + bull + + + +

Secondary Bile Acids Lithocholic Acid Deoxycholic Acid + +

Shiga-like Toxin Escherichia coli EIA + + + + + + +

Zonulin Family Peptide Stool + + +

Page 6: Why Choose Gastrointestinal Testing?...User-Friendly Lab Reports Our gastrointestinal reports feature: • Actionable results related to flagged biomarkers and evaluations that allow

BIOMARKERS REPORTEDGI Effects

Comp2200

GI Effects Micro

2205

GI EffectsGut Path2207

CDSA2000

CDSAP2001

CDSAP 202003

CDSA 20 wo Para

2002

Parasitology

Protozoa

Balantidium coli bull bull bull bull bull

Blastocystis spp bull bull bull bull bull

Chilomastix mesnili bull bull bull bull bull

Cryptosporidium spp bull bull bull bull bull

Cyclospora cayetanensis bull bull bull bull bull

Dientamoeba fragilis bull bull bull bull bull

Entamoeba coli bull bull bull bull bull

Entamoeba dispar bull bull bull bull bull

Entamoeba hartmanni bull bull bull bull bull

Entamoeba histolytica bull bull bull bull bull

Entamoeba polecki bull bull bull bull bull

Endolimax nana bull bull bull bull bull

Giardia bull bull bull bull bull

Iodamoeba butschlii bull bull bull bull bull

Isospora spp bull bull bull bull bull

Trichomonads (eg Pentatrichomonas) bull bull bull bull bull

PCR Parasitology - Protozoa

Blastocystis spp bull bull bull

Cryptosporidium spp bull bull bull

Cyclospora cayetanensis bull bull bull

Dientamoeba fragilis bull bull bull

Entamoeba histolytica bull bull bull

Giardia bull bull bull

Blastocystis spp Reflex Subtyping (Types 1 - 9) bull bull bull

Bacterial Sensitivties (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Mycology Sensitivities (pharmaceutical amp botanical) bull bull bull bull bull bull bull

Additional Findings

Fecal Occult Blood bull bull bull + +

Color bull bull bull bull

Consistency bull bull

Add-on Testing

Campylobacter EIA + + + + + + +

Chymotrypsin + +

Clostridium difficile EIA + + + + + + +

Helicobacter pylori Stool Antigen EIA + + + + + + +

KOH Preparation for Yeast + + bull

MacrospcopicDirect Examination for Parasites + + bull + + + +

Secondary Bile Acids Lithocholic Acid Deoxycholic Acid + +

Shiga-like Toxin Escherichia coli EIA + + + + + + +

Zonulin Family Peptide Stool + + +