who am i? what can i do? how do i live? · structural effect of dendrimers upon gelation. h n n ome...
TRANSCRIPT
Who am I? What can I do? How do I live?
1. Why did you take a doctorate in foreign nation ? 2. Why did you select not America and Europe but Japan as destination to
study abroad ?
Who am I? The Answer is variable.
Who am I?
Kyoungpook National University
Excellent Student
What can I do? No Answer
What can I do? No Answer1 year after, I entered army without dream.
What can I do?
I can do anythingor nothing!
What can I do? What should I do?
I likes Chemistry. But….
What did I do?
I registered 6:40 AM class of language school of the University for 2 years to learn Japanese.
What happens?6:40 AM is too early to take a class.
Most students disappear within one month.
1:1 lesson from Japanese teacher.
How do I live?
Working?
Recruiting of LG Semiconductor
Application form
Yes
Recommendation
Prof. Inn-Kyu Kangin KPNU
Studying
No
LG Semicon. Ltd.was disappeared 1 year later
by the crisis of Korean Economy.
To study advanced field.
Going to abroadJapan or America?
I am already good at Japanese
Pass the Japanese Government Scholarship Exam.
Physical Gelation of Dendrimer in Organic Solvents
Jang, W. –D.; Jiang, D. –L; Aida, T. J. Am. Chem. Soc. 2000, 122, 3232.
O
O
O
O
O
O
O
CO2Me
CO2MeCO2Me
MeO2C
Dipeptide
What did I do in Ph.D. program?
Structural Effect of Dendrimers upon Gelation
H NN
O Me
H
OH
H
MeH
O
N-Dendronized
H NN
O H
H
OH
H
MeH
O
tertBuO2C NN
O Me
H
OH
H
MeH
O
O-Dendronized
O-Methylated N-Deprotected
Change of Dendron
tertBuO2C NOH
H
OHNN
OH
O H
MeH
H
N-Deprotected O-Methylated/N-Deprotected
Cyclized Mono-peptide
O-Methylated
tertBuO2C NN
H
OH
H
MeH
O O
O
O
O
CH2
O
O
O
MeO2C
CO2Me
CO2Me
MeO2C
tertBuO2C NN
O H
H
OH
H
MeH
O
O OO
O
CH2
O
O
O
MeO2C
MeO2C CO2Me
CO2Me
tertBuO2C NN
O H
H
OH
H
MeH
O
O OO
O
CH2
O
O
O
MeO
MeO
MeO OMe MeO OMe
OMe
OMe
H NN
H
OH
H
MeH
O O
O
O
O
CH2
O
O
O
MeO2C
CO2Me
CO2Me
MeO2C
NN
O Me
H
OH
H
MeH
O
O
O
O
O
O
O
CO2Me
MeO2C
MeO2C
O
CO2Me
NN
O H
H
OH
H
MeH
O
O
O
O
O
O
O
CO2Me
MeO2C
MeO2C
O
CO2Me
W.-D. Jang, T. Aida,
Macromolecules, 2003.
Nanofiber Formation of Self-Assembled Dendrimer
Regular Thickness (6 nm) Fibrou s Assembly Formation!!
8.2 nm
5.4 nm
2.7 nm
0.0 nm
1.3 nm
4.0 nm
6.7 nm
O
OHN
O
O
ON
NHH
NHO
O
ON
NHH
OO
OO
O
O
O
O
O
O
O
OOMe
OMe
OMeMeO
OMeMeO
MeO
OMeOMe
MeO
MeOOMe
OMeMeO
OMe
OMe
O
O
OO
OO
O
O
O
O
O
O
O
OMeO
MeO
MeOOMe
MeOOMe
OMe
MeOMeO
OMe
OMeMeO
MeOOMe
MeO
MeO
W.–D. Jang, T. Aida Macromolecules 2004, 37, 7325–7330.
NNN
NZn
O
O
O
NNN
NZn
O
O
O
NH
HN
N
N
NN N
NZn
O
O
O
NN N
NZn
O
O
O
N
N
NNZn
OO
O
N
N
NNZn
OO
O
N
N
NNZn
OO
O
N
N
NNZn
OO
O
N
N N
NZn
OO
NN
NN
Zn
O
O
NN
NNZn
O
O
N N
NNZn
O
O
OO
O
O
O
O
N N
NNZn O
O
NN
NN Zn
O
ONN
NN Zn
OO
N
NN
NZn
OO
O
O
OO
O
O
N
NN
NZn
OO
N
NN
NZn
O
O
NN
NN
Zn
O
O
NN
N NZn
O
O
OO
O
O
O
O
NN
N NZnO
O
NN
NNZn
O
O NN
NNZn
OO
N
N N
NZn
O O
O
O
OO
O
O
NHNHN
N
9mer9mer 17mer17mer
MeO
MeO
NH
HN
N
N
NN N
NZn
O
O
O
NN N
NZn
O
O
O
OMeMeO
OMeMeO
NN
NNZn
O
O
N N
NNZn
O
O
N N
NN Zn O
O
NN
NN Zn
O
O
O
O
O
O
O
O
OMeMeO
OMeMeO
MeO
MeO
NH N
HNN
3mer3mer 5mer5mer
Artificial Light Harvesting System
Physical Gelation of Dendrimer in Organic Solvents
O
O
O
O
O
O
O
CO2Me
CO2MeCO2Me
MeO2C
Dipeptide
How can I find physical gel?
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
OHN O
O
No Polymerization
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
NH
OHHNO
O
O O
Introducing Spacer
1 g of dendrimer gelled 500 mL of EA
Serendipity
What did I do in Postdoc period?
Laser
Administration of Photosensitizer
Delivery
Treatment
Photodynamic Therapy
π
Conjugation(Long Wavelength Absorption)
π Conjugation(Long Wavelength Absorption)
Hydrophobic Propertiesπ-Stacking
Hydrophobic Propertiesπ-Stacking
QuenchingQuenching
Limitation of Conventional Photosensitizers
PhotosensitizerPhotosensitizer
S0
S1
T1LightFL
PL
ISC
3O2
1O2
Type II ReactionEnergy
Transfer
OxygenOxygen
Type I ReactionElectron Transfer (Free Radical Process)
O2
O2- (Superoxide)
PhotosensitizerPhotosensitizer
S0
S1
T1LightFL
PL
ISC
3O2
1O2
Type II ReactionEnergy
Transfer3O2
1O2
Type II ReactionEnergy
Transfer3O2
1O2
Type II Reaction
3O2
1O2
Type II ReactionEnergy
Transfer
OxygenOxygen
Type I ReactionElectron Transfer (Free Radical Process)
O2
O2- (Superoxide)
OxygenOxygen
Type I ReactionElectron Transfer (Free Radical Process)
O2
O2- (Superoxide)
Type I ReactionElectron Transfer (Free Radical Process)
O2
O2- (Superoxide)
Encapsulation of Photosensitizers
No Self-Quenching Effect !!
Block Copolymer
(~60 nm)Dendrimer Porphyrin Micelle (DP/m)
Dendrimer Porphyrin (DP)
-
-
--
--
-
--
--
-
+
+ + + + +
+ + ++
Dendrimer Porphyrin Polyion Complex Micelle
EPR (Enhanced Permeability and Retention) Effect
Photodynamic TherapyFormation of Polyion Complex Micelle
Enhanced Photodynamic Efficacy
in vivo PDT Effect (Cancer, wet AMD, Corneal Neovascularization)
What did I do in Postdoc period?
What I am doing now
Real Time Therapy
Monitoring
Nano-Device for Real Time Treatment
Multifunctional Nano- Device for Therapeutic Application
The First Chemistry Department in Korea22 Faculty MemberTop Level Education & Research in Korea
College of Science Department of Chemistry
Who am I? How do I live?
The ‘I’ is variable.What you do now is able to change your
‘I’ in the future.
Chi-Hwa LeeJongsu KimJungmi HeoKwangmo ChoiSoohyun KimDongyong KimEunyoung Lee
Prof. Inn-Kyu KangKyungpook National UniversityProf. Takuzo AidaProf. Kazunori KataokaThe University of Tokyo
Fund: Center for Bioactive Molecular Hybrids, KOSEFKorea Research Fund
AcknowledgementAcknowledgement