what is valvular heart disease? - medicinebau.com · rvh, tr rhf . pathophysiology narrowing of...
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What Is Valvular Heart Disease?
Heart valve disease occurs when your heart's valves do not work the way they should.
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How Do Heart Valves Work?
MAINTAIN ONE-WAY BLOOD FLOW THROUGH YOUR HEART
The four heart valves make sure that blood always flows freely in a forward direction and that there is no backward leakage.
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Heart Valves
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ANY DISEASE OF THESE VALVES ARE CALLED AS VALVULAR HEART DISEASE!
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Types of valve disease
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Valvular Stenosis
THE VALVE OPENING NARROWS the valve leaflets may become fused or thickened that the
valve cannot open freely obstructs the normal flow of blood
EFFECTS:
the chamber behind the stenotic valve is subject to greater stress
must generate more pressure (work hard) to force blood through the narrowed opening
initially, the compensates for the additional workload by
gradual hypertrophy and dilation of the myocardium
heart failure
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Valvular Regurgitation
LEAKAGE OR BACKFLOW OF BLOOD RESULTS FROM INCOMPLETE CLOSURE OF THE VALVE
due to:
- Scarring and retraction of valve leaflets
OR
- Weakening of supporting structures
EFFECTS:
causes the to pump the same blood twice
(as the blood comes back into the chamber)
the dilates to accommodate more blood
ventricular dilation and hypertrophy eventually leads to
heart failure
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Principal Causes •Valve stenosis •Valve regurgitation
• Congenital
• Rheumatic carditis
• Senile degeneration
• Congenital
• Rheumatic carditis
(acute or chronic)
• Infective endocarditis
• Valve ring dilatation
(e.g. dilated cardiomyopathy)
• Syphilitic aortitis
• Traumatic valve rupture
• Damage to chordae
and papillary muscle
(e.g. MI)
• Senile degeneration
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Valvular Heart Disease
1. MITRAL STENOSIS
2. MITRAL REGURGITATION
3. AORTIC STENOSIS
4. AORTIC REGURGITATION
5. TRICUSPID STENOSIS
6. TRICUSPID REGURGITATION
7. PULMONARY STENOSIS
8. PULMONARY REGURGITATION
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1. MITRAL STENOSIS
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Aetiology
Almost always rheumatic in origin
Older people: can be caused by heavy calcification of mitral valve congestion
Congenital (rare)
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Pathophysiology Normal mitral valve
orifice is 5cm2 in diastole & may be reduced to 1cm2 in severe mitral stenosis
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Pathophysiology
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Pathophysiology
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Pathophysiology
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Pathophysiology
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Pathophysiology
Atrial fibrillation due to progressive dilatation of the LA is very common. Its onset often precipitates pulmonary oedema
In contrast, a more gradual rise in left atrial pressure tends to cause an increase in pulmonary vascular resistance pulmo. HTN RVH, TR RHF
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Pathophysiology
Narrowing of mitral valve
CO
O2/CO2
exchange (fatigue, dyspnea,
orthopnea)
Left ventricular atrophy
pulmonary congestion
pulmonary pressure
left atrial
pressure Hypertrophy left atrium
blood flow
to left ventricle
Right-sided failure
Fatigue
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Clinical features Symptoms
Breathlessness, cough (pulmonary congestion)
Chest pain (pulmonary hypertension)
Hemoptysis (pulmonary congestion or hypertension)
Fatigue (low cardiac output)
Oedema, ascites (right heart failure)
Palpitation (atrial fibrillation)
Thromboembolic complications
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Clinical features Signs
Atrial fibrillation
Mitral facies (abnormal flushing of the cheeks that occurs from cutaneous
vasodilation in the setting of severe mitral valve stenosis)
Auscultation - Loud first heart sound, opening snap
(created by forceful opening of mitral valve)
- Mid-diastolic murmur (apex)
Crepitations, pulmonary edema, effusions (raised pulmonary capillary pressure)
RV heave, loud P2 (pulmonary hypertension)
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Mitral stenosis
…Lub Hoot…
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Investigations ECG: - right ventricular hypertrophy tall R waves
Chest x-ray: - enlarged LA & appendage
- signs of pulmonary venous congestion
ECHO: - thickened immobile cusps
- reduced valve area
- enlarged LA
- reduced rate of diastolic filling of LV
Doppler: - pressure gradient across mitral valve
Cardiac catheterization: - coronary artery disease
-pulmonary artery pressure
-mitral stenosis and regurgitation
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Management
Medically
Anticoagulant
To reduce the risk of systemic embolism
Digoxin, beta blockers, or rate limiting calcium antagonists
To control ventricular rate in atrial fibrillation
Diuretic
To control pulmonary congestion
Surgically
Mitral balloon valvuloplasty***
Mitral valvotomy
Valve replacement
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Balloon mitral valvuloplasty
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2. MITRAL REGURGITATION
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Mitral regurgitation
Incomplete closure of mitral valve
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Aetiology
Rheumatic disease is the principal cause (in countries where disease is common)
Mitral valve prolapse
Dilatation of the LV and mitral valve ring (e.g. coronary artery disease, cardiomyopathy)
Damage to valve cusps and chordae (e.g. rheumatic heart disease, endocarditis)
Ischaemia or infarction of papillary muscle (MI)
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Pathophysiology
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Pathophysiology Incomplete closure of
mitral valve
vol. of blood ejected
by left ventricle Left atrial pressure
Right-sided heart failure
Left atrial hypertrophy CO
Pulmonary pressure
Backflow of blood to the left atrium
Right ventricular
pressure
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mitral valve prolapse
A.k.a ‘floppy’ mitral valve
One of the most common cause of mild mitral regurgitation
Caused by
congenital anomalies
degenerative myxomatous changes
feature of connective tissue disorders like Marfan’s syndrome
Mitral regurgitation
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mitral valve prolapse
Mildest form:
Valve remains competent but bulges back into atrium during systole mid- systolic click but no murmur
In the presence of regurgitant valve:
Click is followed by a late systolic murmur, which lengthens as the regurgitation becomes more severe
Severe form:
Progressive elongation of chordae tendinae increasing regurgitation Chordal rupture severe regurgitation
Mitral regurgitation
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Clinical Manifestations
SYMPTOMS
Fatigue & weakness – due to CO – predominant complaint
Exertional dyspnea & cough – pulmonary congestion
Palpitations – due to atrial fibrillation (occur in 75% of pts.)
Edema, ascites – Right-sided heart failure
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Clinical Manifestations SIGNS
Atrial fibrillation
Cardiomegally
Apical pansystolic murmur +/- thrill
Soft S1, apical S3
Signs of pulmonary venous congestion (crepitations, pulmonary edema, effusions)
Signs of pulmonary hypertension & right heart failure
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Mitral regurgitation
…Hoot Dub…
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Investigations ECG: - left atrial hypertrophy
- left ventricular hypertrophy
Chest x-ray: - enlarged LA,LV
-pulmonary venous congestion
-pulmonary oedema
ECHO: - dilated LA,LV
- structural abnormalities of mitral valve (e.g. prolapse)
Doppler: - detects and quantifies regurgitation
Cardiac catheterization: - dilated LA,LV
-mitral regurgitation
-pulmonary hypertension
- coexisting coronary artery disease
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Management
Medically
Vasodilators (e.g. ACE inhibitors)
Diuretics
If atrial fibrillation presents,
Anticoagulant
Digoxin
Surgically
Mitral valve repair
OR
Mitral valve replacement
To treat mitral valve prolapse
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3. AORTIC STENOSIS
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Aortic Stenosis Narrowing of the aortic valve
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Aetiology
• INFANTS, CHILDREN, ADOLESCENTS
• Congenital aortic stenosis
• Congenital subvalvular aortic stenosis
• Congenital subvalvular aortic stenosis
• YOUNG ADULTS TO MIDDLE-AGED
• Calcification and fibrosis of congenitally bicuspid aortic valve
• Rheumatic aortic stenosis
MIDDLE-AGED TO ELDERLY
• Senile degenerative aortic stenosis
• Calcification of bicuspid valve
• Rheumatic aortic stenosis
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Pathophysiology
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Pathophysiology
Stiffening/Narrowing of Aortic Valve
Incomplete emptying of left atrium
Left ventricular hypertrophy
Pulmonary congestion Compression of coronary arteries
Right-sided heart failure
CO
Myocardial
O2 needs
Myocardial ischemia (chest pain)
O2 supply
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Clinical features Symptoms
Mild or moderate stenosis: usually asymptomatic
Exertional dyspnea
Angina (due to demands of
hypertrophied LV)
Exertional syncope
Sudden death
Episodes o acute pulmonary oedema
CARDINAL SYMPTOMS
CO fails to rise to meet demand
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Clinical features
• Signs • Ejection systolic murmur
• Slow-rising carotid pulse
• Thrusting apex beat (LV pressure overload)
• Narrow pulse pressure
• Signs of pulmonary venous congestion (e.g. crepititions)
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Investigations ECG: - left ventricular hypertrophy
- left bundle branch block
Chest x-ray: - may be normal
- enlarged LV & dilated ascending aorta (PA view)
- calcified valve on lateral view
ECHO: - calcified valve with restricted opening, hypertrophied LV
Doppler: - measurement of severity of stenosis
- detection of associated aortic regurgitation
Cardiac catheterization: - to identify asst. coronary artery disease
- may be used to measure gradient
between LV and aorta
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Management
Asymptomatic aortic stenosis kept under review
(as the development of angina, syncope, symptoms of low CO or heart failure has a poor prognosis and is an indication for prompt surgery)
Moderate/severe stenosis evaluated every 1-2 years
with Doppler echocardiography (to detect progression in severity)
Symptomatic severe aortic stenosis valve replacement
Congenital aortic stenosis aortic balloon valvuloplasty
Atrial fibrillation or post valve replacement with a
mechanical prosthesis anticoagulant
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4. AORTIC REGURGITATION
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Causes
Congenital:
Bicuspid valve or disproportionate cusps
Acquired:
Rheumatic disease
Infective endocarditis
Trauma
Aortic dilatation (marfan’s syndrome, aneurysm, dissection, syphilis)
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Pathophysiology
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Pathophysiology Incomplete closure of the
aortic valve
Backflow of blood to Left
ventricle
Left ventricular hypertrophy & dilation
Left atrial
pressure
Left-sided heart failure (late stage)
Left atrium hypertrophy
CO
Pulmonary
pressure
Right-sided heart failure Right ventricular
pressure
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Clinical features Symptoms
Mild or moderate aortic regurgitation:
Usually asymptomatic (because compensatory ventricular
dilatation&hypertrophy occur)
Awareness of heartbeat, ‘palpitations’
particularly when lying on the left side, which results from increased in stroke volume
Severe aortic regurgitation:
Breathlessness
Angina
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Clinical features
Pulses:
Large volume or ‘collapsing’ pulse
Low diastolic and increased pulse pressure
Bounding peripheral pulse
Capillary pulsation in nail beds: Quincke’s sign
Femoral bruit(‘pistol shot’): Duroziez’s sign
Head nodding with pulse: de Musset’s sign
Murmurs:
Early diastolic murmur
Systolic murmur (increased stroke volume)
Austin Flint murmur (soft mid-diastolic)
Other signs:
Displaced, heaving apex beat (volume overload)
Pre-systolic impulse
4th heart sound
Crepitations (pulmonary venous congestion)
Signs
characteristic murmur is best heard to the left sternum during held expiration
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Investigations ECG: initially normal,
later left ventricular hypertrophy & T-wave inversion
Chest x-ray: - cardiac dilatation, maybe aortic dilatation
- features of left heart failure
ECHO: - dilated LV
-hyperdynamic LV
- fluttering anterior mitral leaflet
Doppler: - detects reflux
Cardiac catheterization: - dilated LV
-aortic regurgitation
-dilated aortic root
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Management
Treatment may be required for underlying conditions, such as endocarditis or syphilis
Aortic regurgitation with symptoms aortic valve replacement (may be combined with aortic root replacement and coronary bypass surgery)
Asymptomatic patients annually follow up with echocardiography for evidence of increasing ventricular size
Systolic BP should be controlled with vasodilating drugs, such as nifedipine or ACE inhibitors
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5. TRICUSPID STENOSIS
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Tricuspid Stenosis
usually occurs together with aortic or mitral stenosis
may be due to rheumatic heart disease (<5%)
blood flow from right atrium to right ventricle
right ventricular output
left ventricular filling co
systemic pressure
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Tricuspid Stenosis
Symptoms
symptoms of right-sided heart failure
-hepatomegaly
- ascites
-peripheral edema
-neck vein engorgement
co – fatigue,
hypotension
Signs
Raised JVP
Mid-diastolic murmur (best heard at lower left or right sternal edge)
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Tricuspid Stenosis
Management
Valve replacement
Valvotomy
Balloon valvuloplasty
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6. TRICUSPID REGURGITATION
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Tricuspid Regurgitation common, and is most frequently ‘functional’ as a
result of enlargement of right ventricle
an insufficient tricuspid valve allows blood to flow
back into the right atrium venous congestion & right ventricular output blood flow towards the lungs
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Rheumatic heart disease
Endocarditis, particularly in injection drug-users
Ebstein’s congenital anomaly
secondary
Right ventricular dilatation due to chronic left heart failure (‘functional tricuspid regurgitation’)
Right ventricular infarction
Pulmonary hypertension (e.g. cor pulmonale)
Tricuspid Regurgitation
causes
primary
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Tricuspid Regurgitation
Symptoms
Usually non-specific
Tiredness (reduced forward flow)
Oedema
Hepatic enlargement (venous congestion)
Signs
Raised JVP
Pansystolic murmur (left
sternal edge)
Pulsatile liver
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Tricuspid Regurgitation
Management
Correction of the cause of right ventricular overload (if TR is due to right ventricular dilatation)
Use of diuretic and vasodilator treatment of CCF
Valve repair
Valve replacement
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7. PULMONARY STENOSIS
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Pulmonary Stenosis
Symptoms
Fatigue, dyspnea on exertion, cyanosis
Poor weight gain or failure to thrive in infants
Hepatomegaly, ascites, edema
Signs Ejection systolic murmur
(loudest at the left upper sternum & radiating towards the left shoulder)
Murmur often preceded by an ejection sound (click)
May be wide splitting of second heart sound (delay in ventricular ejection
May be a thrill (best felt when patient leans forward and breathes out)
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Investigations ECG: - right ventricular hypertrophy
Chest x-ray: - post-stenotic dilatation in the pulmonary artery
Doppler echocardiography is the definitive investigation
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Management
Mild to modearate isolated pulmonary stenosis is relatively common and does not usually progress or require treatment
Severe pulmonary stenosis percutaneous pulmonary
balloon valvuloplasty
OR
surgical valvotomy
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8. PULMONARY REGURGITATION
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Pulmonary Regurgitation
A rare condition
Usually associated with pulmonary hypertension
which may be
• Secondary of the disease of left side of the heart
• Primary pulmonary vascular disease
• Eisenmenger’s syndrome
Blood flows back into right ventricle right
ventricle and atrium hypertrophy symptoms of
right-sided heart failure
Trivial PR is a frequent finding in normal individuals and has
no clinical significance
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Reference
For videos of heart murmurs:
https://www.youtu be.com/playlist?list =PLB7F86984222A1F 7C