What is analytical chemistry?

• 5 subdisciplines of chemistry

• Some definitions

• In every day life…

• Analytical chemist versus chemical analyst

“My” steps1. Formulate the question2. Select analytical

procedures3. Sampling**

• “Representative” sample• Homogeneous versus

heterogeneous

4. Sample Preparation**Most analyses require a liquid solution:

• Extraction• Digestion

4. Analysis• What type of analysis?

6. Manipulate data• Statistical analysis

7. Interpret results/draw conclusions

8. Communicate results

Types of Analyses

1. Qualitative analysis

2. Quantitative analysis

3. Characterization analysis

4. Fundamental analysis

Some Terminology

• Analyte

• Matrix

• Analysis – Measurement – Determination

• Technique – Method – Procedure – Protocol

Classifying Techniques

• All analyses based on a signal

• Total Analysis Technique – AKA “Classical Method”

• Concentration Technique – AKA “Instrumental Method”

Method Considerations:Analytical Figures of Merit (AFOMs)

• Accuracy• Precision• Sensitivity• Selectivity• Robustness

• Ruggedness• Scale of operation,• Analysis time• Availability of

equipment• Cost

Relevant Reading

• Chpt 1 all• Chpt 3 to 3C

• Chpt 2 (review)