w.g. bessler: list of publications · 2017. 3. 13. · 045 bessler, w., and schindler, p.:...
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W.G. Bessler: List of Publications
001 Stirm, S., Bessler, W., Fehmel, F., Freund-Mölbert, E., and Thurow, H.: Isolation of Spike-
Formed Particles from Bacteriophage Lysates. Virology 45, 303-308 (1971).
002 Stirm, S., Bessler, W., Fehmel., F., Freund-Mölbert, E.: Bacteriophage Particles with Endo-
Glycosidase Activity. J. Virol. 8, 343-346 (1971).
003 Bessler, W.: Isolierung und Charakterisierung einiger virusinduzierter Enzyme aus
Bakteriophagen-Lysaten. Dissertation. Freiburg (1972).
004 Stirm, S., Bessler, W., Fehmel, F., Freund-Mölbert, E., Rudolph, C., and Thurow, H.:
Bacteriophagen-Glycosidasen. Hoppe-Seyler's Z. Physiol. Chem. 353, 760-761 (1972).
005 Stirm, S., Bessler, W., Fehmel., F., and Freund-Mölbert, E.: Escherichia coli-
Kapselphagen. Zbl. Bakt. Hyg., I. Abt. Orig. A 220, 484 (1972).
006 Bessler, W., Freund-Mölbert, E., Knüfermann, H., Rudolph, C., Thurow, H.,and Stirm, S.:
A Bacteriophage-Induced Depolymerase Active on Klebsiella K 11 Capsular
Polysaccharide. Virology 56, 134-151 (1973).
007 Bessler, W., and Goldstein, I. J.: Phytohemagglutinin Purification: A General Method
Involving Affinity and Gel Chromatography. FEBS Lett. 34, 58-62 (1973).
008 Stirm, S., Bessler, W., Fehmel, F., Freund-Mölbert, E., and Thurow, H.: Über eine
Bakteriophagen-induzierte Colansäure-Depolymerase. Zbl. Bakt. Hyg., I. Abt. Orig.
226, 26-35 (1974).
009 Bessler, W., Shafer, J. H., and Goldstein, I. J.: A Spectrophotometric Study of the
Carbohydrate Binding Site of Concanavalin A. J. Biol. Chem. 249, 2819-2822 (1974).
010 Bessler, W., and Goldstein, I. J.: Equilibrium Dialysis Studies on Two Lima Bean Lectins.
Arch. Biochem. Biophys. 165, 444-445 (1974).
011 Ruddon, R. W., Weisenthal, L. M., Lundeen, D. E., Bessler, and W., Goldstein, I. J.:
Stimulation of Mitogenesis in Normal and Leukemic Human Lymphocytes by Divalent
and Tetravalent Lima Bean Lectins. Proc. Nat. Acad. Sci. USA 71, 1848-1851 (1974).
012 Bessler, W., Ruddon, R. W., Weisenthal., L. M., Lundeen, D. E., and Goldstein, I. J.:
Mitogenität di- und tetravalenter Lektine aus Limabohnen (Phaseolus lunatus) gegenüber
normalen und leukämischen Humanlymphozyten. In: Abstracts der 5. Arbeitstagung
für Leukozytenkulturen, Erlangen (1974).
013 Bessler, W., Ruddon, R. W., Goldstein, I. J., Ferber, E., and Resch, K.: Interaktion von
Limabohnen-Lektinen mit Lymphozyten verschiedener Spezies. Z. Immun.-Forsch. 147,
229 (1974).
014 Bessler, W., Fehmel, F., Freund-Mölbert, E., Knüfermann, H., and Stirm, S.: Escherichia
coli Capsule Bacteriophages IV. Free Capsule Depolymerase 29. J. Virol. 15, 976-984
(1975).
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015 Bessler, W., and Braun, V.: Mitogenität von Lipoprotein aus der äußeren Membran von E.
coli gegen Lymphozyten verschiedener Spezies. Z. Immun.-Forsch. 150, 193 (1975).
016 Bessler, W. and Resch, K.: The Role of Valence in Lectin-Lymphocyte Interactions. In:
Abstracts of Symposia, Colloquia, and Poster Contributions 10th Meeting of the
Federation of the European Biochemical Societies, Paris, (ed.: Societe de Chimie
Biologique), Nr. 997 (1975).
017 Bessler, W., Hantke, K.and Resch, K.: Induction of Cell Proliferation and Membrane
Changes by Derivatives of Lipoprotein from the Outer Membrane of E. coli. Z. Immun.-
Forsch. 152, 75 (1976).
018 Bessler, W., Resch., K., and Ferber., E.: Valency-Dependent Stimulating Effects of Lima
Bean Lectins on Lymphocytes of Different Species. Biochem. Biophys. Res. Comm. 69,
578-585 (1976).
019 Frisch, A., Bessler, W., Lipps, H. J., and Ammermann, D.: Immobilization of Ciliates by
Concanavalin A. J. Protozool. 12, 427-430 (1976).
020 Bessler, W. G., and Lipps, H. J.: Concanavalin A-induced Nuclear Division in Stylonychia
mytilus. J. Gen. Microbiol. 92, 221-223 (1976).
021 Bessler, W. G.: Bohnenextrakte zum Kampf gegen den Krebs. Umschau in Wissenschaft
und Technik 76, 83-84 (1976).
022 Kraut, H., and Bessler, W. G.: Valence Dependent Stimulation of Rat Lymphocytes by
Isolectins from the Lima Bean. In: Abstracts of the 10th International Congr. of
Biochemistry, Hamburg, 480 (1976).
023 Bessler, W., Saal, J., Hadam, M., and Rieber, P.: Stimulation of Subpopulations of Normal
and Leukemic Human Lymphocytes with Lima Bean Lectin. In: Abstracts of the 7th
Workshop on Leukocyte Cultures Ulm, (1976).
024 Lipps, H. J., and Bessler, W.: Interaction of Stylonychia mytilus with Concanavalin A. In:
Abstracts of the 10th International Congress of Biochemistry, Hamburg 531 (1976).
025 Bessler, W., and Ottenbreit, B. P.: Studies on the Mitogenic principle of the Lipoprotein
from the Outer Membrane of Escherichia coli. Biochem. Biophys. Res. Comm. 76, 239-
246 (1977).
026 Bessler, W. G., and Hantke, K.: Mitogenicity of Derivatives of the Lipoprotein from the
Outer Membrane of Escherichia coli. In: Regulatory Mechanisms in Lymphocyte
Activation. Academic Press, New York, 420-422 (1977).
027 Bessler, W., Resch, K., Hancock, E., and Hantke, K.: Induction of Lymphocyte
Proliferation and Membrane Changes by Lipopeptide Derivates of the Lipoprotein from
the Outer Membrane of Escherichia coli. Z. Immun.-Forsch. 153, 11-22 (1977).
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028 Büsing, D., and Bessler, W. G.: Lymphocyte Stimulation with Lima Bean Lectins: Valency
Dependent Membrane Alterating Activity of the Isolectins. Z. Immun. Forsch. 153, 293-
294 (1977).
029 Bessler, W. G., Schimmelpfeng, L., and Peters, J. H.: Potentiation of Mitogen-induced
Lymphocyte Stimulation by Polyethylene Glycols. Biochem. Biophys. Res. Comm. 76,
1253-1260 (1977).
030 Lipps, H. J., and Bessler, W. G.: Early Nuclear Events Following the Interaction of the
Ciliate Stylonchia mytilus with the Plant Lectin Concanavalin A. Cell Differentiation 6,
187-197 (1977).
031 Lipps, H. J., Knowles, J. K. C., Nock, A., and Bessler W: Translation of Specific RNA in
an Homologous in vivo System. In: Abstracts, of the 11th FEBS Meeting, Copenhagen
(1977).
032 Bessler, W., and Resch, K.: Studies on the Mitogenic Principle of Lipoprotein. In:
Abstrakts der 8. Arbeitstagung über Leukozytenkulturen. Berlin (1977).
033 Büsing, D., Kraut, H. J., and Bessler, W. G.: Valency Dependent Membrane Phospholipid
Altering Activity of Lima Bean Isolectins in Bovine and Human Lymphocytes. In:
Abstracts of the 11th FEbS Meeting, Copenhagen (1977).
034 Bessler, W. G., Lützeler, E., Rotering, H., and Hantke, K.: Minimal Structure Required for
Mitogenicity of the Lipoprotein from the Outer Membrane of E. coli. In: Abstracts of the
11th FEBS Meeting, Copenhagen (1977).
035 Bessler, W. G., and Braun, V.: Lipoprotein from the Outer Membrane of Escherichia coli:
Molecular Structure and Mitogenicity. In: H. Peters (ed.): Protides of the Biological
Fluids. Pergamon Press, Oxford, New York, Toronto, Sydney, Paris, Frankfurt, 33-
36 (1978).
036 Bessler, W.: Einführung in die Biologie. Studienbrief Biochemie 4: Zellmembranen,
Ultrastruktur der Zelle. Deutsches Institut für Fernstudien. Tübingen (1978).
037 Haas, I., Cybulla, J., and Bessler, W. G.: Lipoprotein from the Outer Membrane of E. coli:
The Minimal Molecular Structures Required for Mitogenicity. Z. Immun.-Forsch. 155,
21 (1978).
038 Peters, J. H., Bessler, W. G., and Schimmelpfeng, L.: On the Significance of a Mitogen
Presentation by Macrophages to Lymphocytes. Z. Immun.-Forsch. 155, 52 (1978).
039 Bessler, W. G., Peters, H. J., and Schimmelpfeng, L.: Two Steps in T-Lymphocyte
Activation: Lymphocyte Stimulating Factors from mitogen-treated Macrophages and from
a Cultured Macrophage Cell Line. In: Abstracts of the 9th Workshop in Leukocyte
Cultures, Mainz. 6c (1978).
040 Peters, J.H., Schimmelpfeng, L., and Bessler, W. G.: Two Steps in Mitogenic T-
Lymphocyte Activation: Conditioning of the Lymphocyte Membrane for a Macrophage
Derived Stimulatory Signal. In: Abstracts of the 9th Workshop on Leukocyte
Cultures, Mainz. 49C (1978).
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041 Bessler, W. G., Lützeler, E., and Rotering, H.: Studies on the Mitogenic Principle of the
Lipoprotein from the Outer Membrane of E. coli: Investigations with Mutant
Lipoproteins. In: Abstracts of the 12th International Leukocyte Culture Conference,
Beersheba, Israel, June 25-30, 8 (1978).
042 Haas, I., Simon, E., and Bessler, W. G.: Effect of the Aggregational State on the
Mitogenicity of the Lipoprotein from the Outer Membrane of Escherichia coli.
Immunobiol. 156, 418-428 (1979).
043 Bessler, W. G., and Henning, U.: Protein I and Protein II* from the Outer Membrane of
Escherichia coli are Mouse B-Lymphocyte Mitogens. Z. Immun.-Forsch. 155, 387-398
(1979).
044 Bessler, W., and Henning, U.: Mitogenic Bacterial Surface Components: B-Lymphocyte
Stimulatory Activity in vitro of Protein I from the Outer Membrane of Escherichia coli.
In: G. Kaplan (ed.): The Molecular Basis of Immune Cell Function. Elsevier/ North
Holland, Biomedical Press, Amsterdam, 503-506 (1979).
045 Bessler, W., and Schindler, P.: Purification of 2-Deoxy-2-Dansylamido-D-Glucose by
Affinity Chromatography on a Lectin-Loaded Agarose Column. Experentia 35, 1292
(1979).
046 Kraut, H., Resch, K., and Bessler, W. G.: Lima Bean Lectins as Mitogens for Human T-
Lymphocytes: Isolation of Receptor Membrane Proteins. In: H. Peters (ed.): Protides of
the Biological Fluids. Pergamon Press, Oxford, New York, Toronto, Sydney, Paris,
Frankfurt, XXVII, 619-622 (1979).
047 Peters, J. H., Bessler, W. G., and Schimmelpfeng, L.: Adherent Cells as Targets in
Mitogenic T-Lymphocyte Stimulation: Replacement of Lymphocyte-Bound Mitogens by
Non-Mitogenic Substances. Immunol. Comm. 8, 425-433 (1979).
048 Bessler, W., Cybulla, J., Frey, A., and Hillemann, J.: Bacterial Cell Surface Components as
B-Lymphocyte Mitogens: Minimal Structures Required for Mitogenicity. Immunobiol.
156, 213-214 (1979).
049 Däumling, C., Lipps, H. J., Schimmelpfeng, L., Peters, J. H., and Bessler, W. G.:
Macrophage Participation in T-Lymphocyte Activation by Mitogens: Mitogenic Factors
from Macrophages and from a Macrophage Cell Line Effect Protein Biosynthesis in vitro.
Hoppe-Seyler's Z. Physiol. Chem. 360, 247 (1979).
050 Bessler, W. G., Frey, A., Haas, I., and Resch, K.: Interaction of B-lymphocyte Mitogens
with the Plasma Membrane of Leukocytes. Hoppe-Seyler's Z. Physiol. Chem. 360, 1128
(1979).
051 Bessler, W. G., Ottenbreit, B., Irmscher, G., and Jung, G.: Interaction of Membrane
Modifying Peptide Antibiotics from Trichoderma viride with Leukocytes. Biochem.
Biophys. Res. Comm. 87, 99-105 (1979).
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052 Haas, I. G., and Bessler, W., G.: Mitogenicity of E. coli Lipoprotein Aggregates and the
Effect of Anti-Lipoprotein. In: Abstrakts der 10. Arbeitstagung über
Leukozytenkulturen, Marburg (1979).
053 Bessler, W. G., and Henning, U.: Bacterial Surface Components as Mitogens: B-
Lymphocyte Stimulatory Activity of Protein I from the Outer Membrane of E. coli. In:
Abstrakts der 10. Arbeitstagung über Leukozytenkulturen, Marburg (1979).
054 Bessler, W. G., and Kraut, H.: Interaktion von Lektinen aus Limabohnen (Phaseolus
lunatus) mit Lymphozyten. In: Abstracts, "Kolloquium über natürliche Agglutinine
und Proteinasehemmer", Köln (1979).
055 Resch, K., Bessler, W. G., and Kraut, H.: Lima Bean Lectins as Mitogens for Human T-
Lymphocytes: Isolation of Receptor Membrane Proteins. In: Abstracts, of the 27th
Colloquium, Protides of Biological Fluids (1979).
056 Bessler, W.G., and Henning, U.: Mitogenic Bacterial Surface Components: B-lymphocyte
Stimulatory Activity in vitro of Protein I from the Outer Membrane of E. coli. In:
Abstracts of the 13th International Leucocyte Culture Conference, Ottawa, 98
(1979).
057 Bessler, W., G., Simon, E., and Rotering, H.: Mitogenicity of a Lipid-Deficient Lipoprotein
from a Mutant Escherichia coli Strain. Infect. Immunity 28, 818-823 (1980).
058 Cybulla, J., Brückner, H., Jung, G., Wipperfürth, T., and Bessler, W. G.: The Mitogenic
Principle of Escherichia coli Lipoprotein: B-Lymphocyte Mitogenicity of N-Palmitoyl-
Cysteine and N- Palmitoyl-Glutamic Acid-a-Methyl Esters. Biochem. Biophys. Res.
Comm. 92, 1389-1396 (1980).
059 Scheuer, W., Frey, A., Maldener, M., and Bessler, W. G.: Bacterial Cell-Surface
Components as B-Lymphocyte Receptors from Mouse Splenocytes and from a Mouse
Macrophage Cell Line. Immunobiol. 157, 274-275 (1980).
060 Bessler, W. G., and Resch, K.: Activation of Lymphocyte Populations with Con A or with
Lipoprotein and Lipopeptide from E. coli: Correlation of Early Membrane Changes with
Induction of Macromolecular Synthesis. In: Abstracts of the 4th International
Congress of Immunology, Paris, 7-2-04. (1980).
061 Jung, G., Brückner, H., Maldener, M., Scheuer, W., Resch, K., and Bessler, W. G.: New
Synthetic Mitogens Constituting the Minimal Structure Required for Mitogenicity of the
Lipoprotein from the Outer Membrane of E. coli. In: Abstracts of the 4th International
Congress of Immunology, Paris, 19-1-05 (1980).
062 Cybulla, J., Brückner, H., Jung, G., Wipperfürth, Th., and Bessler, W. G.: The Mitogenic
Principle of Escherichia coli Lipoprotein: B-Lymphocyte Mitogenicity of N-Palmitoyl-
Cysteine and N-Palmitoyl Glutamic Acid a-Methyl Esters. In: Abstrakts der 11.
Arbeitstagung über Leukozytenkulturen, Erlangen, 4-F. (1980).
063 Bessler, W. G.: Abwehrmechanismen gegen bakterielle Infektionen. Biologie in unserer
Zeit 11, 1-6 (1981).
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064 Resch, K., and Bessler, W. G.: Activation of Lymphocyte Population with Concanavalin A
or with Lipoprotein or Lipopeptide from the Outer Cell Wall of Escherichia coli:
Correlation of Early Membrane Changes with Induction of Macromolecular Synthesis.
Eur. J. Biochem. 115, 247-252 (1981).
065 Johnson, R. B., Köhl, S., Jung, G., and Bessler, W. G: In vivo Polyclonal B-Lymphocyte
Activation with Salmonella typhimurium Lipoprotein and a Synthetic Analogue.
Immunobiol. 160, 50 (1981).
066 Bessler, W. G., Kustermann-Kuhn, B., and Scheuer, W. V.: B-Lymphocyte-Mitogen
Binding Proteins of Mouse Splenocytes: Enrichment of Binding Proteins for the
Lipoprotein from Escherichia coli. In: H. Kirchner, K. Resch (eds.): Mechanisms of
Lymphocyte Activations. Elsevier/North Holland, 476-479 (1981).
067 Bessler, W. G., and Scheuer, W.: Receptors on B-Lymphocytes for Mitogenic Bacterial
Surface Components. In: Abstracts of the 65th FASEB Meeting, Atlanta, USA,
Federation Proc., 5263 (1981).
068 Bessler, W. G., Kustermann-Kuhn, B., and Scheuer, W. V.: B-Lymphocyte Mitogen
Binding Proteins in the Plasma Membrane of Mouse Splenocytes. Immunobiol. 159, 123
(1981).
069 Hermann, G., Schmidt-Horstmann, B., Habets, L., Karalus, I., Guertler, L., and Bessler, W.:
A Polyagglutinating, Non-Mitogenic Lectin from Arion Empiricorum. In: T. C. Bog-
Hansen (ed.): Lectins, Biology, Biochemistry, Clinical Biochemistry. Vol. 2, Walter
de Gruyter, Berlin, New York, 657-677 (1982).
070 Maier, B. F., Baron, D. P., Bockhorn, H., Drautz, H., Langhärig, J., and Bessler, W. G.:
Mitogenic and Suppressive Activity of Mycelia from Gram Positive Bacteria on Murine
and Human Lymphocytes. Immunbiol. 163, 427-435 (1982).
071 Bessler, W.G., Johnson, R.B., Wiesmüller, K.H., and Jung, G.: B-Lymphocyte Mitogenicity
in vitro of a Synthetic Lipopeptide Fragment Derived from Bacterial Lipoprotein. Hoppe-
Seyler’s Z. Physiol.Chem. 363, 767-770 (1982).
072 Mieth, K.B., Johnson, R.B. Köhl, S., and Bessler, W.G.: Defined fragments of bacterial
protein I and lipoprotein are Mouse B-lymphocyte mitogens. Immunobiol. 162, 395
(1982).
073 Bessler, W.G., Wiesmüller, K.H., Scheuer, W., Johnson, R.B., Brückner, H., and Jung, G.:
Synthetic Peptide Derivatives of Bacterial Lipoprotein and Their Interaction with
Lymphocyte Plasma Membranes. In: Abstracts of the 4th Symposium on Chemistry of
Peptides and Proteins, Tübingen (1982).
074 Bessler, W.G., Johnson, R.B., Maier, B.F., Drautz, H., Langhärig, J., Bockhorn, G., and
Baron, D.B.: Mitogenic and Suppressive Activity of Mycelia from Gram-Positive Bacteria
on Murine and Human Lymphocytes. In: Abstracts of the 12th Workshop on
Leukocyte Cultures, Wien, 3 (1982).
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075 Maier, B., Baron, D., Bessler, W., Bockhorn H., Degen H., Hark, T., and Winkelmann, G.:
Die Inhibierung cellulärer in vitro Immunreaktionen durch Herbicolin und
Streptomycetenextrakt. Langenbeck's Arch. f. Chirurgie. 31-35 (1982).
076 Bessler, W.G., Kraut, H., Müller-Hermes, W.H.P., and Peters, J.H.: Membrane Alterations
and Induction of Responsiveness to Interleukin 2 in Lymphocytes by Lima Bean Lectins.
In: Abstracts of the 5th International Lectin Meeting, Bern, Schweiz (1982).
077 Bessler W.G., Kraut, H., Büsing, D., Müller-Hermes, W.J.P., and Peters, J.H.: Membrane
Alterations and Induction of Responsiveness to Interleukin 2 in Lymphocytes by Lima
Bean Lectins. In: T.C. Bog-Hansen, G.A. Spengler (eds.): Lectins. Biology,
Biochemistry, Clinical Biochemistry. Vol. 3, Walter de Gruyter, Berlin, New York,
45-54 (1983).
078 Johnson, R.B., Köhl, S., and Bessler, W.G.: Polyclonal Activation of B-Lymphocytes In
Vivo by Salmonella typhimurium Lipoprotein. Infect. Immun. 39, 1481-1484 (1983).
079 Scheuer, W.V., and Bessler, W.G.: Binding of Bacterial Lipoprotein and Synthetic
Analogues to Histocompatibility-2-Complex Proteins of Mouse Lymphocytes. In:
Abstracts der Jahres-Tagung der DGHM/ASM, Tübingen (1983).
080 Wiesmüller, K.H., Bessler, W., and Jung, G.: Synthesis of the Mitogenic S-(2,3-
Bis(palmitoyloxy)propyl)-N- palmitoylpentapeptide from E. coli Lipoprotein. Hoppe-
Seyler's Z. Physiol. Chem. 364, 593-606 (1983).
081 Jung, G., Hennings, G, Pfeifer, M., and Bessler, W. G.: Interaction of Metal Complexing
Compounds with Lymphocytes and Lymphoid Cell Lines. Mol. Pharmacol. 23, 698-702
(1983).
082 Johnson, R. B., Köhl, S., Wiesmüller, K. H., Jung, G., and Bessler, W. G.: Synthetic
Analogues of the N-Terminal Lipid Part of Bacterial Lipoprotein are B-Lymphocyte
Mitogens in vitro and in vivo. Immunobiol. 165, 27-35 (1983).
083 Johnson, R. B., Scheuer, W. V., and Bessler, W. G.: Serum-Mediated Suppression and
Enhancement of Polyclonal B-Cell Activation. In: Parker, J.W. & O'Brien, R.L. (eds.)
Intercellular Communication in Leucocyte Function. John Wiley & Sons,
Chichester, New York, Brisbane, Toronto, Singapore. 225-228 (1983).
084 Bessler, W. G., Johnson, R. B., Wiesmüller, K. H., v. Tittle,T., and Jung, G.: A Synthetic
Lipopeptide Derivative of Bacterial Lipoprotein is a Potent Polyclonal B-Cell Activator.
In: Parker, J.W. & O'Brien, R.L. (eds.) Intercellular Communication in Leucocyte
Function. John Wiley & Sons, Chichester, New York, Brisbane, Toronto, Singapore.
245-248 (1983).
085 Jung, G., Wiesmüller, K. H., Scheuer, W., and Bessler, W. G.: Synthesis and Biological
Activities of the Mitogenic Principle of E. coli Lipoprotein. In: Abstracts of the 24th
Internat. Conference on the Biochemistry of Lipids, Toulouse (France), 723 (1983).
086 Scheuer, W. V., Müller, H., and Bessler, W. G.: Histocompatibility-2-complex proteins of
mouse leukocytes are binding proteins for mitogenic bacterial lipoprotein and synthetic
analogues. Immunobiol. 165, 349-350 (1983).
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087 Bessler, W. G., and v. Tittle, T.: Synthetic analogues of bacterial lipoprotein: mitogenicity
of tripalmitoyl pentapeptide towards mouse lymphocytes and the BCL1 lymphoid cell
line. Immunbiol. 165, 240 (1983).
088 Bessler, W. G., Bessler, U., Eck, G., Scheuer, W.V., and Suhr B.: In vitro-Methoden zur
Testung pflanzlicher, bakterieller und synthetischer Agenzien und Toxine unter
Anwendung von Leukozyten-Primärzellkulturen und -Zellinien.
Arzneimittelforschung/Drug Research 35 (II), 1209-1215 (1983).
089 Jung, G., Wiesmüller, K. H., Scheuer, W., and Bessler, W. G.: Synthesis and Biological
Activities of the Mitogenic Principle of E. coli Lipoprotein. In: V.J. Hruby and D.H.
Rich (eds) Peptides, Structure and Function. Pierce Chem. Corp., Rockford Ill, 179-
82 (1983).
090 Jung, G., Carrera, C., Brückner, H., and Bessler, W. G.: The Mitogenic Principle of
Escherichia coli Lipoprotein: Synthesis, Spectroscopic Characterization, and Mitogenicity
of N-Palmitoly-S-((2R,S) 2,3-dipalmitoyloxypropyl))-(R)-cysteine Methyl Ester. Liebigs
Ann. Chem. 1983, 1608-1622 (1983).
091 Bessler, W. G., Hennings, G., Pfeiffer, M., Jung, G.: Interaktion Metall-komplexierender
Flavonoide mit Lymphozyten und lymphoiden Zell-Linien. In: Proceedings of an
International Workshop on Cianidanol, Bad Kreuznach. (1984).
092 Bessler, W. G., Wiesmüller, K. H., Scheuer, W., Johnson, R. B., Fouad, H. H., and Jung,
G.: Synthetic Peptide Derivatives of Bacterial Lipoprotein and their Interaction with
Lymphocyte Plasma Membranes. In: W. Völter et al. (eds.): Chemistry of Peptides and
Proteins, Walter de Gruyter Vol. 2, 88-96 (1984).
093 Bessler, W.G., Cox, M., Wiesmüller, K.H., and Jung, G.: The Mitogenic Principle of
Escherichia coli Lipoprotein: B-Lymphocyte Mitogenicity of the Synthetic Analogue
Palmitoyl-Tetrapeptide (PAM-SER-SER-ASN-ALA). Biochem. Biophys. Res. Comm.,
121, 55-61 (1984).
094 Kleine, B., Coutinho, A. und Bessler, W.: Membrane Proteins in Lipopolysaccharide
reactive and nonreactive B-cell blasts and B-cell tumors. In: Abstracts 14.
Leukozytenkulturen Konferenz, Hamburg (1984).
095 Lüdemann, J., Bessler, W. and W. L. Gross: Role of Outer Membrane Proteins in the
Polyclonal B-cell Activation Process Started by a Crude Klebsiella Cell Membrane
Preparation. In: Abstracts 14. Leukozytenkulturen Konferenz, Hamburg (1984).
096 Bessler, W.G., Biesert, L., Lex, A., Mieth, K. and Vordermeier, H.-M.: Recognition of
Bacterial Surface Components by Lymphocytes: The Minimal Molecular Structures of
Bacterial Lipoprotein and Protein I Required for B-Lymphocyte Activation. In: Abstracts
14. Leukozytenkulturen-Konferenz, Hamburg (1984).
097 Lüdemann, J., Schlegelberger, T., Bessler, W., Brade, H.,: Role of Lipopolysaccharides and
Outer Membrane Proteins in the B-Cell Maturation Process Induced by Various
Enterobacteriae. In: Abstracts of the XV. Annual Meeting of the Scandinavian Society
for Immunology, Odense, Denmark (1984).
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098 Held, H., Lüdemann, J., Brade, H., Bessler, W., Gross, W.L.: Polyklonale Aktivierung
menschlicher B-Zellen durch verschiedene Zellwandkomponenten von
Enterobacteriaceae. In: Abstrakts der 90. Tagung der Deutschen Gesellschaft für
innere Medizin, Wiesbaden (1984).
99 Gross, W.L., Lüdemann, J., Bessler, W., and Braun, V.: Role of Lipoprotein and Murein in
the Polyclonal B-Cell Activation Process Started by a Crude Klebsiella Cell Membrane
Preparation. In: Abstracts der Jahrestagung der Europ. Ges. f. Immunologie, 15
Interlaken, Schweiz (1984).
100 Lex, A., Vordermeier, H.M., Sprenger, R., Suhr, B., Bessler, W.G.: Immunomodulation by
synthetic analogues of bacterial lipoprotein and by fragments of bacterial protein I.
Immunobiol. 168, 71 (1984).
101 Streck, H., Biesert, L., Wiesmüller, K.H., Jung, G., Bessler, W.: Binding proteins for
mitogenic bacterial lipoprotein and synthetic analogues on B-lymphocytes and on
lymphoid B-cell line. Immunobiol. 168, 10 (1984).
102 Lüdemann, J., Gross, W.L., Mayer, H., Bessler, W.: The activation of human lymphozytes
by enterobacteriaceae is not due to enterobacterial common antigen stimulation.
Immunobiol. 168, 5-6 (1984).
103 Bessler, W.G., Flad, H.-D., Schade, U., Rietschel, E.: Lymphokine Induction in Murine and
Human Leukocytes by Bacterial Lipoprotein and a Synthetic Analogue, and by Bacterial
Protein I. Lymphokine Research, 3, 234 (1984).
104 Jung, G., Wiesmüller, K.H., Metzger, J., Lex, A., Bessler, W., Leibfritz, D., Praß, W.,
Ringsdorf, H.: The N-Terminus of E. coli Lipoprotein: Synthesis, Immunogenicity,
Spectroscopy and Monolayer Forming Properties of a Potent Mitogen. In: Proceedings of
the 24th International Conference on the Biochemistry of Lipids, Toulouse (1984).
105 Jung, G., Wiesmüller, K.-H., Metzger, J., Scheuer, W., Lex, A., Bessler, W., Leibfritz, D.,
Praß, W., Ringsdorf, H.: The N-Terminus of E. Coli Lipoprotein: Synthesis,
Immunogenicity, Spectroscopy, and Monolayer Forming Properties of a Potent Mitogen.
In: Proceedings of the 24th International Conference on the Biochemistry of Lipids,
Toulouse (1984).
106 Kleine, B., Martinez, C., Bessler, W., and Coutinho, A.: Functional recognition of B cell
mitogens by reactive B cell blasts and B cell lymphomas: Membrane proteins in
lipopolysaccharide reactive and nonreactive cells. Immunobiol. 167, 5 (1984).
107 Jung G., Wiesmüller K.H., Scheuer W., Lex A., Bessler W.G., Leibfritz D., Praß W.,
Ringsdorf H.: B-Lymphocyte Mitogenicity and Biophysical Properties of Synthetic N-
Terminal Lipopeptides of "E. Coli" Lipoprotein. Sclavo International Conference on
Synthetic Antigens. Siena, Italy, 58-62 (1984); Annali Sclavo, 191-208 (1984).
108 Kleine, B., Bessler W.G., Coutinho A.: Segregation of reactivity to the mitogens
lipopolysaccharide, lipoprotein and dextran sulfate in clones of the B cell lymphoma line
WEHI 279.1. Eur. J. Immunol. 15, 207-209 (1985).
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10
109 Bessler W.G., Lex A., Vordermeier H.-M., Sprenger R., Suhr B.: Synthetische Analoge des
bakteriellen Lipoproteins sowie Fragmente von Protein I sind Immunomodulatoren in
vitro und in vivo. In: Abstrakts der Frühjahrstagung ASM, DGHM, Würzburg
(1985).
110 Jung G., Wiesmüller K.H., Metzger J., Becker G., Biesert L., Bessler W.G., Leibfritz D.,
Praß W., Ringsdorf H., Bühring H.: Synthese, mitogene und biophysikalische
Eigenschaften N-terminaler Segmente des Lipoproteins. In: Abstrakts des DFG
Peptidsymposium, Bad Nauheim, 23 (1985).
111 Bessler W.G., Cox M., Lex A., Suhr B., Wiesmüller K.-H., Jung G.: Synthetic lipopeptide
analogs of bacterial lipoprotein are potent polyclonal activators for murine B
lymphocytes. In: The Journal of Immunology, The American Association of
Immunologists, 1900-1905 (1985).
112 Lex A., Ortmann A., Wiesmüller K.H., Jung G., Bessler W: Lymphocyte activation and
immunomodulatory activity of synthetic analogues of bacterial lipoprotein and by
fragments of bacterial protein I. In: Abstracts der 1. Frühjahrstagung der Gesellschaft
für Immunologie, Tübingen, WS 1-5 (1985).
113 Grygar G., Köhl S., Dopfer R., Bessler W., Wiesmüller K.H., Jung G., Niethammer D:
Activation of human granulocytes by bacterial surface components and their synthetic
analoga. In: Abstracts der 1. Frühjahrstagung der Gesellschaft für Immunologie,
Tübingen, WS 6-5 (1985).
114 Sprenger R., Kleine B., Bessler W.G: Screening of reactivitiy to bacterial Lipoprotein in H-
2 Recombinant inbred mice and in newly established strains derived from wild mice. In:
Abstracts der 1. Frühjahrstagung der Gesellschaft für Immunologie, (1985)
115 Bessler W., Schlecht S., Lex A., Ortmann A., Wiesmüller K.H., Jung G: Synthetic analoga
of bacterial lipoprotein are potent immunoadiuvants. Abstract. Proceedings of the Joint
Conference. Ithaca, New York, August 3-8, (1985).
116 Jung G., Becker G., Bessler W., Biesert L., Bühring H., Metzger J., Muller C., Wiesmüller
K.H: Potent B-Lymphocyte mitogens as covalently bound carriers for the presentation of
antigens and enhancement of immune response. Abstract. In: Proceeding of the USSR-
FRG Symposium on Peptides and Proteins. 21, Odessa, May 1985.
117 Lex A., Ortmann A., Wiesmüller K.H., Jung G., Bessler W: Lymphocyte-activation and
immunomodulatory activity of synthetic analogues of bacterial lipoprotein.
Posterbeitrag, Würzburg, ASM (1985).
118 Gross W.L., Lohmann C., Wuthe H.H., Bessler W: Lymphozytenantwort auf
hochgereinigte Biostrukturen gramnegativer Bakterien bei reaktiven Arthritiden. In:
Klinische Wochenschrift, Autoreferate zur 91. Tagung der Deutschen Gesellschaft
für innere Medizin, Wiesbaden, 39, 14.-18. April (1985).
119 Bessler W., Suhr B., Bühring H.J., Muller C.P., Wiesmüller K.H., Becker G., Jung G:
Specific antibodies elicited by antigen covalently linked to a synthetic adjuvant.
Immunobiol. 170, 6-7 (1985).
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120 Bessler W.G., Suhr B., Bühring H.J., Muller C.P., Wiesmüller K.H., Becker G., Jung G:
Specific antibodies elicited by antigen covalently linked to a synthetic adjuvant.
Immunobiol. 170, 239-244 (1985).
121 Hoffmann P., Vordermeier H.M., Biesert L., Heinle S., Bessler W.G: Induction of
interleukin I in murine adherent cells by a synthetic analogue, and by bacterial protein.
Immunobiol. 170, 1/2, 33 (1985).
122 Sprenger R., Kleine B., Bessler W: Reactivity to bacterial lipoprotein and lipopolysaccharid
qualitative and quantitative analysis in a panel of murine strains including H-2
recombinant lines with established and newly derived haplotypes. Immunobiol. 170, 1/2,
92 (1985).
123 Kleine B., Dölker I., Sels F., Bessler W: Membrane proteins specific for B-lymphocytes in
vitro translation of membrane bound mRNA and comparison of products of B and T cells.
Immunobiol. 170, 1/2, 42-43 (1985).
124 Jung G., Wiesmüller K.-H., Becker G., Bühring H.-J., Bessler W.G.: Increased Production
of Specific Antibodies by Presentation of the Antigen Determinants with Covalently
Coupled Lipopeptide Mitogens. In: Angewandte Chemie:VCH Verlagsgesellschaft
mbH, Weinheim, 872-873 (1985)
125 Jung G., Wiesmüller K.H., Metzger J., Bühring H.J., Muller C.P., Biesert L., Bessler W:
Enhancement of Immune Response Using B-Lymphocyte Mitogens Covalently Linked to
Antigens. Proceedings of the Ninth American Peptide Symposium Proceedings.
Toronto, Canada (1985).
126 Lüdemann J., Gross W.L., Bessler W., Braun V: Human B-Cell Differentiation Induced by
Murein. Immunol. Lett., 10, 293-296 (1985).
127 Bessler W: Bakterielle Immunadjuvantien und synthetische Analoga. In: Volker Sill (ed)
Kongreßbericht der 19. Wissenschaftlichen Tagungen der Norddeutschen
Gesellschaft für Lungen-und Bronchialheilkunde, Universimed Verlag, Frankfurt,
166-172 (1985).
128 Jung, G., Wiesmüller, K.-H., Becker, G., Bühring, H.-J., Bessler, W.G.: Verstärkte
Produktion spezifischer Antikörper durch Präsentation der antigenen Determinanten mit
kovalent verknüpften Lipopeptid-Mitogenen. Sonderdruck Angewandte Chemie 97, 883-
885 (1985)
129 Bessler W., Schlecht S., Bühring H., Jung G: Enhancement of the Immune Response by
Mitogenic Lipopeptide Adjuvants Combined with or Covalently Bound to Antigens.
Eingereicht: International Symposium on Immunological Adjuvants and Modulators
of Non-Specific Resistance to Microbial Infections. Columbia, Maryland, USA, 30
June - 3 July 1986.
130 Reitermann, A.C., Riehle, A., Metzger, J., Wiesmüller, K.H., Jung, G., and Bessler, W.G.:
Mitogenic lipopeptide derivatives of bacterial lipoprotein enhance the immune response
combined with or covalently coupled to antigens or haptens. Immunobiol. 173, 199
(1986).
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131 Kleine, B., Biesert, L., and Bessler, W.G.: Specific expression of membrane proteins in
lipopolysaccharide or lipoprotein activated B lymphocytes. Immunobiol. 173, 155-156
(1986).
132 Wagner-Roos, L., Hauschildt, S., and Bessler, W.G.: Effects of synthetic lipopeptide B-
lymphocyte mitogens on proteinkinase C and phosphoinositide metabolism. Immunbiol.
173, 164 (1986).
133 Bessler, W., and Suhr, B.: Die Aktivierung von B-Lymphozyten bei der Immunantwort.
Biologie in unserer Zeit 16, 33-38 (1986).
134 Bessler, W., Kleine, B., Cox, M., Lex, A., Suhr, B., Wiesmüller, K.H., Jung, G., and
Martinez-Alonso, C.: Synthetic lipopeptide analogues of peptidoglycan-associated
lipoprotein are potent novel B-lymphocyte mitogens. In: Seidel, P.H., Schleifer, K.H.
(Eds.): Biological Properties of Peptidoglycan, Walter de Gruyter, Berlin, New
York, 335-340 (1986).
135 Bessler, W., Jung, G., Bühring, H., and Schlecht, S.: Mitogenic Lipopeptides as Covalently
Bound Carriers for the Presentation of Antigens and Enhancement of the Immune
Response. In: Abstracts of the 6th International Congress of Immunology, Toronto,
Canada (1986).
136 Vordermeier, M., Stäb, K., and Bessler, W.: A Defined Fragment of Bacterial Protein I
(OmpF) is a Polyclonal B-Cell Activator. Inf. Immunity 51, 233-239 (1986).
137 Vordermeier, M., Wagner-Roos, L., Rau, D., Reitermann, A., Bessler, W.: B-Lymphocyte
Activation by Defined Fragments of Bacterial Protein I and by Synthetic Analogues of
Bacterial Lipoprotein. In: Abstracts der 2. Frühjahrstagung der Gesellschaft für
Immunologie, Erlangen (1986).
138 Bessler, W., Lex, A., Suhr, B., Ortmann, A., Schlecht, S., Bühring, H., Muller, C., Metzger,
J., Wiesmüller, K.H., and Jung, G.: The Synthetic Analoga of Bacterial Lipoprotein are
Potent Immunoadjuvants in Combination with or Covalently Linked to Antigen.
Leukocytes and Host Defense, 337-344 (1986).
139 Lex, A., Wiesmüller, K.H., Jung, G., and Bessler, W.: A Synthetic Analogue of Escherichia
coli Lipoprotein, Tripalmitoyl Pentapeptide, Constitutes a Potent Immune Adjuvant. J.
Immunol. 137, 2676-2681 (1986).
140 Scheuer, W.V., Biesert, L., and Bessler, W.: Binding of a Synthetic Analogue of Mitogenic
Bacterial Lipoprotein to Murine Major Histocompatibility Complex (MHC) Gene
Products. Biol. Chem. Hoppe-Seyler 367, 1085-1094 (1986).
141 Biesert, L., Scheuer, W., and Bessler, W.: Interaction of mitogenic bacterial lipoprotein and
a synthetic analogue with mouse lymphocytes: Isolation and characterization of binding
proteins. Eur. J. Biochem. 162, 651-657 (1987).
142 Kleine, B., Biesert, L., Dölker, I., Sprenger, R., Vordermeier, H.M., Countinho, A., and
Bessler, W.G.: Funktional Recognition of Bacterial Mitogens by Reactive B Lymphocytes
Related to Membrane Protein Composition. In: E. Wagner et al. (Eds.): The Cell
Surface in Signal Transduction. Springer Verlag Berlin Heidelberg, 87-99 (1987)
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143 Kleine, B., Sprenger, R., Martinez-Alonso, C., and Bessler, W.G.: Polyclonal B-cell
activation by a synthetic analogue of bacterial lipoprotein is functionally different from
activation by bacterial lipopolysaccharide. Immunol. 61, 29-34 (1987).
144 Vordermeier, H.M., and Bessler, W.G.: Polyclonal activation of Murine B Lymphocytes in
vitro by Salmonella typhimurium Porins. Immunobiol. 175, 245-251 (1987).
145 Vordermeier, H.M., Drexler, H., and Bessler W.G.: Polyclonal activation of human
peripheral blood lymphocytes by bacterial porins and defined porin fragments. Immunol.
Lett. 15, 121-126 (1987).
146 Hauschildt, S., Wagner-Roos, L., Möck, W., and Bessler W.G.: Lipopeptide Mediated
Transmembrane Signaling in Macrophages and B-Lymphocytes. In: Abstracts der
Frühjahrstagung der Deutschen Gesellschaft für Zellbiologie, Heidelberg (1987).
147 Böltz, T., Jung, G., Wiesmüller, K.H., Metzger, J., and Bessler W.G.: Enhancement of the
Immune Response Using a Synthetic B-Lymphocyte Mitogen Covalently Linked to
Antigens. In: Abstracts of the 18th International Leucocyte Culture Conference, La
Grande-Motte, France (1987).
148 Schlecht, S., Jung, G., and Bessler W.G.: Immunoenhancing activity of heterologous
bacteria and some of their cell wall components on the protective capacity of
S.typhimurium vaccines. In: Abstracts of the International Symposium on
Immunomodulators and Nonspecific Host Defence Mechanisms Against Microbial
Infections, Berlin (1987).
149 Hauschildt, S., Wagner-Roos, L., Möck, W., and Bessler, W.G.: Biochemical Events
During Transmembrane Signaling in B-Lymphocytes and Macrophages Induced by
Mitogenic Lipopeptides and Lipopolysaccharide. In: Abstracts of the 3.
Frühjahrstagung der Gesellschaft für Zellbiologie, Heidelberg (1987).
150 Wagner-Ross, L., Kleine, B., Hauschildt, S., and Bessler, W.G.: Early signals during
lymphocyte activation triggered by mitogenic lipopeptide or lipopolysaccharide (LPS).
Immunobiol. 175/4, 368-369 (1987).
151 Böltz, T., Schauerte, K., Koch, P., Metzger, J., Wiesmüller, K.H., Jung, G., and Bessler
W.G.: Immunoglobulin subclass-specific responses to synthetic B lymphocyte-activating
lipopeptides covalently linked to antigens. Immunobiol. 175/4, 365 (1987).
152 Hoffmann, P., Kreutz, M., Reitermann, A., Hauschildt, S., Jung, G., and Bessler W.G.:
Induction of cytotoxicity and interleukin 1 production in bone marrow derived
macrophages by synthetic analogues of bacterial lipoprotein. Immunobiol. 175/4, 373
(1987).
153 Hauschildt, S., Wagner-Roos, L., and Bessler W.G.: Role of proteinkinase C and
phospatidylinositol metabolism in lipopeptide-induced leukocyte activation as signal
transducing mechanism. In:Molecular Immunology, 1081-1086 (1988)
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14
154 Hauschildt, S., Wagner-Roos, L., Bessler, W.G.: Lipopeptide induced transmembrane
signalling in leucocytes. Evidence for the involvement of protein kinase C and inositol
trisphosphates. In: Abstracts der Herbsttagung der Gesellschaft für Biologische
Chemie, Erlangen (1987).
155 Szamel, M., Goppelt-Strübe, M., Bessler, W., Wiesmüller, K.H., and Resch, K.: Separation
of plasma membrane domains of calf thymocytes by affinity chromatography on ouabain-
Sepharose. Biochim. Biophys. Acta 899, 247-257 (1987).
156 Bessler, W. G.: Bakterielle Oberflächenkomponenten als Adjuvantien der Immunantwort in
vitro und in vivo. Asthma, Bronch., Emphes. 7, 23-24 (1987).
157 Wagner-Roos, L., Hauschildt, S., Möck, W., and Bessler, W.G.: Synthetic lipopeptides as
B-lymphocyte growth and differentiation factors: Effects on proteinkinase C and
phosphoinositide metabolism. In: Lymphokine Research 6, 1821 (1987).
158 Bessler, W.G., and Hauschildt, S.: Bakterielle Lipopeptide als Immunadjuvantien. Forum
Mikrobiologie, 4, 106-111, (1987).
159 Prass, W., Ringsdorf, H., Bessler, W., Wiesmüller, K.H., and Jung, G.: Lipopeptides of the
N-terminus of E. coli lipoprotein: synthesis, mitogenicity and properties in monolayer
experiments. Biochim. Biophys. Acta. 900, 116-128 (1987).
160 Böltz, T., Schauerte, K., Koch, P., Reitermann, A., Jung, G., Wiesmüller, K.-H., Metzger,
J., and Bessler, W.G.: Synthetic lipopeptide B-lymphocyte mitogens covalently linked to
antigens enhance the antigen specific humoral immune response. In: Abstracts der 3.
Frühjahrstagung der Gesellschaft für Immunologie, Lübeck (1987).
161 Jung, G., Kabatek, U., Kern, A., Metzger, J., Wiesmüller, K.-H., Bühring, H.-J., Muller,
C.P., and Bessler, W. G.: Efficient Production of Antibodies by Antigen Presentation via a
New Carrier/Adjuvant System. In: Chmiel, H., Hammes, W.P. & Bailey J.E. (eds.),
Biochemical Engineering Gustav Fischer Verlag, Stuttgart (1987).
162 Bessler, W.G., Hauschildt, S., and Wagner-Roos, L.: Leukocyte activation by synthetic
analogs of bacterial lipoprotein: lipopeptide induced transmembrane signaling involving
protein kinase C and inositol trisphosphates. In: Abstracts of the Second International
Conference on Lymphocyte Activation and Immune Regulation, Newport Beach,
USA (1988).
163 Kleine, B., Hirner, K., and Bessler, W.G.: Specific Dephosphorylation of a 110 kDa
Membrane Phosphoprotein by Lipopolysaccharide Exclusively in B Lymphocytes and
Macrophages of the C57BL/6 Strain. In: Abstracts der Frühjahrstagung der
Gesellschaft für Immunologie, Hannover (1988).
164 Becker, G., Bühring, H.J., Jung, C.C., Jung, G., Muller, C., Tröger, W., Wiesmüller, K.-H.,
and Bessler, W.G.: Specific humoral immune response towards predicted epitopes of the
epidermal growth factor receptor (EGFR) conjugated to lipopeptide adjuvant. Submitted
for publication (1988).
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165 Böltz, T., Bessler, W.G., Jung, G., Wiesmüller, K.H., and Metzger, J.: Enhancement of the
immune response using a synthetic B-lymphocyte mitogen covalently linked to antigens.
In: J.C. Mani, J.C. Dornand (Eds.): Lymphocyte Activation and Differentiation.
Walter de Gruyter & Co. Berlin, New York, 379-382 (1988).
166 Hauschildt, S., Hirt, W., and Bessler, W.G.: Modulation of protein kinase C activity by NaF
in bone marrow derived macrophages. FEBS Lett. 230, 121-124 (1988).
167 Heinle, S., Stünkel, K., Zähner, H., Drautz, H., and Bessler, W.G.: Immunosuppressive
Effects of the Macrolide Antibiotic Bafilomycin towards Lymphocytes and Lymphoid
Cell Lines. Arzneimittelforsch./Drug Research 38, 1130-1133 (1988).
168 Schlecht, S., Jung, G., and Bessler, W.G.: Immunoenhancing Activity of Heterologous
Bacteria and Some of Their Cell Wall Components on the Protective Capacity of
S.typhimurium Vaccines. Adv. Biosci. 68, 317-321 (1988).
169 Hauschildt, S., Steffens, U., Wagner-Roos, L., and Bessler, W.: Role of Proteinkinase C
and Phosphatidylinositol Metabolism in Lipopeptide-Induced Leukocyte Activation as
Signal Transducing Mechanism. Mol. Immunol. 25, 1081-1086 (1988).
170 Bessler, W.G., Hauschildt S., and Wagner-Roos L.: Leukocyte activation by synthetic
analogues of bacterial lipoprotein: Lipopeptide induced transmembrane signalling
involving protein kinase C and inositol trisphosphates. In: Abstracts of the Second
International Conference on Lymphocyte Activation and Immune Regulation,
Newport Beach, USA (1988).
171 Bessler, W.G., Böltz, T., Tröger, W., Hummel, P., Jung, G.: Charakterisierung der
Immunantwort gegen synthetische HIV-Peptid- Adjuvans-Konjugate. In: Abstracts, 1.
Deutscher AIDS-Kongress, München, 1988.
172 Tröger, W., Hummel, P., Gombert, F., Böltz, T., Bessler, W.G. und Jung, G.: Entwicklung
vollsynthetischer HIV-Vakzine auf der Basis niedermolekularer Lipopeptid-Carrier-
Adjuvants Konjugate. In: Abstracts, 1. Deutscher AIDS-Kongress, München, 1988.
173 Hauschildt, S., Wagner-Roos, L., Wiesmüller, K.-H., Jung, G., and Bessler, W.G.:
Phosphatidylinositol Metabolism and Protein Kinase C Activation in Leukocytes by
Lipopeptides. Immunobiol. 177, 267-277 (1988).
174 Schlecht, S., Wiesmüller, K.H., Jung, G., and Bessler, W.: Enhancement of Protection
against Enterobaceriaceae in Mice Mediated by Synthetic Lipopeptide Analogues of
Bacterial Lipoprotein added in Bacterial Vaccines. Zbl. Bakteriol. 82, in press (1988).
175 Hoffmann, P., Heinle, S., Schade, U.F., Loppnow, H., Ulmer, A.J., Flad, H.D., Jung, G.,and
Bessler, W.G.: Stimulation of Human and Murine Adherent Cells by Bacterial
Lipoprotein and Synthetic Lipopetide Analogues. Immunobiol. 177, 158-170 (1988).
176 Jung, G., and Bessler, W. G.: The Synthetic Lipopeptide Pam3Cys-Ser-Asn-Ala, an Analog
of the N-Terminal Part of Bacterial Lipoprotein, Constitutes a Potent Macophage and B
Lymphocyte Activator. In: Abstracts of the Second International Conference on
Lymphocyte Activation and Immune Regulation, Newport Beach, USA (1988).
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177 Hauschildt S., Wagener-Roos, L. M., Wiesmüller, K.-H., Jung, G., Bessler, W. G.: The
Synthetic Lipopeptide Pam3CYS-Ser-SER-ASN-ALA, an analog of the N-Terminal Part
of Bacterial Lipoprotein, constitutes a potenet Macrophage and B Lymophocyte Activator.
In: Abstracts of the Second International Conference on Lymphocyte Activation and
Immune-Regulation, Newport Beach, USA (1988).
178 Kleine, B., and Bessler, W.G.: A 110 KD Membrane Phosphoprotein is the Prime
Candidate for the Functional Lipopolysaccharide (LPS) Receptor. FASEB J. 2: A 1230
(1988).
179 Hauschildt, S., Steffens, U., and Bessler, W.: Lipopeptide Induced Activation of
Leukocytes: Role of Proteinkinase C and Phosphatidylinositol Metabolism. In: Abstracts
of the 19th International Leucocyte Culture Conference, Banff, Canada (1988).
180 Steffens, U., Hauschildt, S., and Bessler, W.G.: Induction of B Cell stimulation by
lipopeptide through a mechanism not Involving cAMP, cGMP and inositoltrisphosphate.
Immunobiol. 178, 54 (1988).
181 Bender, A., Nain, M., Hinder, F., Horch, S., Bessler, W. and Gemsa, D.: Influenza A virus-
induced release of tumor necrosis factor-alpha (TNF-alpha) from macrophages is
enhanced by lipopolysaccharide (LPS), lipid A, and lipopeptides. Immunobiol. 178, 59
(1988).
182 Wiedemann, F., Böltz, T., Hummel, R.-P., Tröger, W., Jung, G., Schauerte, K., and Bessler,
W.G.: Detection of HIV-1 and HIV-2 infections using lipopeptide conjugates as antigens
in enzyme immunoassay. Immunobiol. 178, 73-74 (1988).
183 Reitermann, A., Metzger, J., Jung, G., Bessler, W.G., and Böltz, T.: B cell autoreactive
repertoire following immunization with the polyclonal B cell activators lipopeptide and
LPS. Immunobiol. 178, 51 (1988).
184 Link, R., Böltz, T., Hummel, R.-P., Tröger, W., Jung, G., Koch, P., and Bessler, W.G.:
Immunogenicity of synthetic oligopeptides corresponding to epitopes of friends murine
leukemia virus glycoprotein covalently linked to lipopeptides. Immunobiol. 178, 64
(1988).
185 Wolf, B., Hauschildt, S., Uhl, B., Metzger, J., Jung, G., and Bessler, W.G.: Electron energy
loss spectroscopy (EELS) as a novel method to localize the leukocyte activator
lipopeptide in the lymphoid cell line BCL1 and in bone marrow-derived macrophages.
Immunobiol. 178, 101 (1988).
186 Hoffmann, P., and Bessler, W.G.: Tumor cytotoxicity involving TNF induced in bone
marrow-derived macrophages by two lipopeptide analogues of bacterial lipoprotein.
Immunobiol. 178, 94 (1988).
187 Böltz, T., Hummel, R.-P., Tröger, W., Rübsamen-Waigmann, H., Biesert, L., Müller-
Lantzsch, N., Koch, P., Bessler, W., and Jung, G.: Distinction between HIV-1 and HIV-2
infection using novel synthetic lipopeptide conjugates as antigens in enzyme
immunoassays. J. of Virol. Meth. 22, 173-182 (1988).
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17
188 Brade, L., Bessler, W.G., and Brade, H.: Mitogenic Activities of Synthetic Escherichia coli
Lipid A and a Synthetic Partial Structure (Tripalmitoyl Pentapeptide) of E. coli
Lipoprotein. Infect. Immun. 56, 1382-1384 (1988).
189 Bessler, W.G., und Baron, D.: Die Herstellung und Anwendung monoklonaler Antikörper.
Naturwissenschaften 75, 496-502 (1988).
190 Hauschildt, S., and Bessler, W.G.: Role of inositol starvation on ecto-5'-nucleotidase
activity during mitogen-induced lymphocyte activation. Immunol. Lett. 19, 71-76 (1988).
191 Bessler, W.G.: Bakterielle Oberflächenkomponenten und synthetische Analoga als
Adjuvantien der Immunantwort in vitro und in vivo. Asthma, Bronch. Emphys. 1, 9-10
(1988).
192 Hauschildt, S., Steffens, U., Wolf, B., and Bessler, W.: Lipopeptide induced signal transfer
in bone marrow derived macrophages. Biol. Chem. Hoppe-Seyler 369, 833 (1988).
193 Hummel, R.-P., Tröger, W., Jung, G., Bessler, W.G., and Böltz, T.: Development of a HIV-
1 and HIV-2 specific ELISA. In: Abstracts Intern. Conf. on AIDS, Stockholm, Sweden
(1988).
194 Andreesen R., Brugger, W., Galanos, C., Bessler, W., Rehm, A., and Löhr, G.W.: Sensitive
Inhibition of Human Monocyte to Macrophage Differentiation by Bacterial Endotoxins
and Synthetic Lipoeptide Analogues. In: Abstracts 30th Annual Meeting of The
American Society of Hematology, (1988).
195 Hummel, R.-P., Tröger, W., Böltz, T., Bessler, W.G., and Jung, G.: Development of HIV-1
and HIV-2 Specific and Selective Enzyme Linked Immunosorbent Assay Based on
Tripalmitoyl-S-Glyceryl-Cysteinyl-Peptides. In: Abstracts 20th Europ. Peptide
Symposium, Tübingen (1988).
196 Lovett, D. H. Burnsten, S. L. Gemsa, D., Bessler, W. G., Resch, K., And Ryan, J. L:
Activation of Glomerular Masangial Cells by Gram-Negative Bacterial Cell Wall
Components. Am. J. Path., 33, 472-484 (1988).
197 Steffens, U., Bessler, W. G., and Hauschildt, S.: B Cell Activation by Synthetic
Lipopeptide Analogues of Bacterial Lipoprotein Bypassing Phosphatidylinositol
Metabolism and Proteinkinase C Translocation. Mol. Immunol. 26, 897-904 (1989)
198 Hoffmann, P., Wiesmüller, K.-H., Metzger, J., Jung, G. and Bessler, W.G.: Induction of
Tumor Cytotoxicity in Murine Bone Marrow-Derived Macrophages by Two Synthetic
Lipopeptide Analogues. Biol. Chem. Hoppe-Seyler 370, 575-582 (1989).
199 Wolf, B., Hauschildt,S., Uhl, B., Metzger, J., Jung, G., and Bessler, W.G.: Localization of
the cell activator lipopeptide in bone marrow-derived macrophages by electron energy
loss spectroscopy (EELS). Immunol. Lett. 20, 121-126 (1989).
200 Schlecht, S., Wiesmüller, K.-H., Jung, G., and Bessler, W.G. Enhancement of Protection
against Salmonella Infection in Mice Mediated by a Synthetic Lipopeptide Analogue of
Bacterial Lipoprotein in S. typhimurium Vaccines. Zbl. Bakt. 271, 493-500 (1989).
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18
201 Wolf, B., Uhl, B., Hauschildt, S., Metzger, J., Jung, G., and Bessler, W.: Interaction of the
Lymphoid Cell Line BCL1 with Lipopeptide Analogues of Bacterial Lipoprotein: Electron
Energy Loss Spectroscopy (EELS) as a Novel Method to Detect the Distribution of the
Activator within the Cells. Immunobiol., 180, 93-100 (1989)
202 Scheipers, P., Hauschildt, S., Philippi, S., Martinez-Alonso, C., Jung, G., and Bessler,
W.G.: Mechanism of Leukocyte Activation by Bacterial Lipopeptides. In: Abstracts, 7th
Intern. Congress of Immunol., Berlin (1989)
203 Bessler, W.G.: Bacterial lysates and purified bacterial surface components as
immunomodulators. In: Abstracts of the International Symposium on Mucosal
Immunity of the Respiratory Tract, Bad Lippspringe (1989).
204 Kleine, B., and Bessler, W.G.: Lipopolysaccharide Induced Signal Transduction
Mechanism in B Cells and in Bone Marrow-derived Macrophages May Involve
Dephosphorylation of a 185 KD Phosphoprotein. In: Abstracts, 7th Intern. Congress of
Immunol., Berlin (1989)
205 Hauschildt, S., Wolf, B., Uhl, B., Lückhoff, A., and Bessler, W.G.: Lipopeptide Induced
Signal Transfer in B Cells and in Bone Marrow derived Macrophages. In: Abstracts, 7th
Intern. Congress of Immunol., Berlin (1989)
206 Bessler, W., Link, R., Böltz, T., Hummel, R.-P., Tröger, W., Koch, P., and Jung, G.:
Immunogenität synthetischer FMuLV- und HIV-Oligopeptid-Lipopeptid-Konjugate in
Balb/c und STU-Mäusen. In: Abstracts 2. Deutscher AIDS-Kongress, Berlin (1989).
207 Uhl, B., Wolf, B., Hug, R., Hauschildt, S., and Bessler, W.G.: Ultrastructural Alterations in
Bone Marrow derived Macrophages after Stimulation with Lipopeptides. In: Abstracts
der Jahrestagung der Deutschen Gesellschaft für Zellbiologie, Bielefeld (1989).
208 Muller, C.P., Bühring, H. J., Becker, G., Jung, C.C., Jung, G., Tröger, W., Wiesmüller, K.-
H., Saalmüller, A., and Bessler, W.G.: Specific antibody response towards predicted
epitopes of the epidermal growth factor receptor induced by a thermostable synthetic
peptide adjuvant conjugate. Clin. Exp. Immunol., 78, 499-504 (1989).
209 Hummel, R.P., Tröger, W., Biesert, L., Rübsamen-Waigmann, H., Böltz, T., Bessler, W.G.,
and Jung, G.: Distinction of HIV-1 and HIV-2 infection using novel synthetic lipopeptide-
conjugates as antigens in ELISA. In: Jung, G., and Bayer, E. (eds.): Peptides 1988,
Walter de Gruyter, Berlin, New York (1989).
210 Hauschildt, S., Lückhoff, A., Philippi, S., and Bessler, W.G.: Activation of Mouse Bone
Marrow-Derived Macrophages by Bacterial Lipopeptide. In: The Macrophage, Third
Symposium of the Upper Rhine Universities, Freiburg (1989).
211 Kleine, B., Biesert, L., and Bessler, W.G.: The Membrane Protein Compositions of
Lipopolysaccharide- or Lipoprotein-Activated B Lymphoblasts from C57BL LPS-
Responder and Non-Responder Mice are Qualitatively Indistinguishable. Res. Immunol.
140, 685-695 (1989).
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19
212 Schlecht, S., Metzger, J., Wiesmüller, K.-H., Jung, G., Bessler, W. G.: Lipopeptide
Analogues of the N-Terminus of Bacterial Lipoproteins are Adjuvants in S-typhimurium
Vaccines. In: Abstracts der 42. Jahrestagung der Deutschen Gesellschaft für Hygiene
und Mikrobiologie, Hannover (1989).
213 Bessler, W.G. and Jung, G.: Therapy and Prophylaxis of HIV-Infections: Preparation and
Tests of New Lipopeptide Immunogens and Inhibitors. In: Abstracts des 2.
Statusseminars der AIDS-Forschungsförderimg, Bonn (1989).
214 Kline, B., Bessler, W. G., Coutinho, J., Kettman, J.: Global Analysis of Membrane
Proteinsfrom WEHI 279.1 Subclones Reveals Co-Expression of Groups of Proteins. In:
Abstracts for UCLA-Symposion: B-Cell Development, Park City, Utah, USA (1989).
215 Metzger, J., Wiesmüller, K.-H., Kabatek, U., Kerm, A., Schaude, R., Hess, G., and Jung,
G.: New Applications of Low Molecular Weight Antigens Presenting Carrier-Adjuvant
Systems for Elecitation of Antibodies. In: König, W.A. Voelter, W. (eds.), Chemistry of
Peptides and Proteins, 263-268 (1989).
216 Reitermann, A. Metzger, J. Wiesmüller, K.-H., Jung, G., and Bessler W. G.: Lipopeptide
Derivatives of Bacterial Lipoprotein Constitute Potent Immune Adjuvants Combined with
or Covalently Coupled to Antigen or Hapten. Biol. Chem. Hoppe-Seyler 370, 343-352
(1989).
217 Mülsch, A., Hauschildt, S., Bessler, W.G., Bassenge, E., and Busse, R.: Cytosolic Nitric
Oxide Synthesis from L-arginine by Murine Bone Marrow Macrophages and Porcine
Aortic Endothelial Cells. In: Abstracts for the Royal Society London (1989).
218 Bessler, W. G., and Jung, G.: Therapy and Prophylaxis of HIV-Infections: Preparation and
Tests of Novel Lipopeptide Immunogens and Inhibitors. In: Progress in Aids Research
in the Federal Republic of Germany, Bonn (1989).
219 Strecker, M., Jung, G., Bessler, W. G.: The active principle of bacterial surface
components: bacterial lysates and synthetically prepared membrane components as
immunomodulators. In: Abstracts des 8th Congress of SEP, The European
Respiratory Journal, European Society of Pneumology, European Pediatric
Respiratory Society, Freiburg 1989).
220 Bessler, W.G., Kleine, B., Martinez-Alonso, C., Biesert, L., Strecker, M., Wiesmüller, K.-
H., Metzger, J., and Jung, G.: Biological Activity of Bacterial Surface Components:
Bacterial Extracts and Defined Bacterial Cell Wall Components as Immunmodulators. In:
Lung, Vol. 168, Suppl. 1990, 707-715 (1990).
221 Vordermeier, H.-M., Hoffmann, P., Gombert, F.O., Jung, G., and Bessler W. G.: Synthetic
Peptide Segments from the Escherichia coli Porin OmpF Constitute Leukicyte Activators.
Infection and Immunity 58, 2719-2724 (1990).
222 Hoffmann, P., Jimenez-Diaz, M., Loleit, M., Tröger, W., Jung, G., and Bessler, W.G.:
Preparation of human and murine monoclonal antibodies: Lipopeptide antigen conjugates
constitute potent immunogens for in vitro and in vivo immunizations. In: Abstracts 1st
International Conference on Human Antibodies and Hybridomas, Orlando, Florida,
USA (1990).
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20
223 Wolf, B. and Bessler, W. G.: Elektronen-Energieverlust-Spektroskopie (EELS) als Methode
zur Lokalisierung von Antigenen und anderen Substanzen in Zellen und Geweben.
Naturwissenschaften 77, 110-115 (1990).
224 Seifert, R., Schultz, G., Richter-Freund, Metzger, J., Wiesmüller, K.-H., Jung, G., Bessler,
W.G., and Hauschildt, S.: Activation of superoxide formation and lysozyme release in
human neutrophils by the synthetic lipopeptide Pam3Cys-Der-(Lys)4: Involvement of
guanine-nucleotide-binding proteins and synergism with chemotactic peptides. Biochem.
J. 267, 795-802 (1990).
225 Wiesmüller, K.-H., Hess, G., Bessler, W. G., and Jung, G.: Diastereomers of tripalmitoyl-S-
glyceryl-L-cysteinyl carrier adjuvant systems induce different mitogenic and protective
immune response. In: Holmstedt, G., Frank, H., and Testa, G. (eds.): Chirality and
Biological Activity, A. Liss Inc. New York, 267-272 (1990).
226 Kreutz, M., Hauschildt, S., Bessler, W. G., and Andreesen, R.: Induction of the cytokine
repertoire in human monocytes and monocyte-derived macrophages by synthetic bacterial
lipopeptides. In: The Macrophage, Fourth Symposium of the Upper Rhine
Universities, Freiburg (1990).
227 Hauschildt, S., Bassenge, E., Bessler, W., Busse, R., and Mülsch, A.: l-arginine dependent
nitric oxide formation and nitrite release in bone marrow-derived macrophages stimulated
with bacterial lipopeptide and lipopolysaccharide. Immunology 70, 332-337 (1990).
228 Bessler, W.G., Jung, G., and Hauschildt, S.: Modulation of B lymphocyte activation by
lipopeptides: Molecular mechanisms of transmembrane signalling. In: Abstracts 3rd
International Conference on Lymphocyte Activation and Immune Regulation,
Newport Beach (1990).
229 Seifert, R., Hauschildt, S., and Bessler, W.G.: A Synthetic Lipopeptide Activates Human
Neutrophils through Pertussis Toxin-Sensitive and -Insensitive Mechanisms. Naunyn-
Schmiedeberg's Arch. Pharmacol., suppl. to Vol. 341 (1990).
230 Loleit, M., Tröger, W., Wiesmüller, K.-H., Jung, G., Strecker, M., and Bessler, W.G.:
Conjugates of synthetic lymphocyte activating lipopeptides with segments from HIV
proteins induce protein specific antibody formation. Biol. Chem. Hoppe-Seyler 371, 967-
975 (1990).
231 Müller, B., Wiesmüller, K.-H., Jung, G., Bessler, W.G., Hoffmann, P.: Induction of tumor
cytotoxicity in murine bone marrow-derived macrophages by chemically altered
lipopeptide analogues of bacterial lipoprotein. In: Abstracts der 6. Frühjahrstagung
der Gesellschaft für Immunologie, Marburg, (1990).
232 Hauschildt, S., Mülsch, A., Busse, R., and Bessler, W.: A lipopeptide derived from
bacterial lipoprotein induces the "oxidative L-arginine pathway" in bone marrow derived
macrophages. In: Abstracts der 6. Frühjahrstagung der Gesellschaft für
Immunologie, Marburg, (1990).
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21
233 Kaufmann, H., Kleine B., and Bessler, W.G.: Dephosphorylation of a 185 kd
phosphoprotein may be involved in lipopolysaccharide induced signal transduction
mechanisms in B cells and in bone marrow derived macrophages. In: Abstracts of the 1st
Congress of the International Endotoxin Society, San Diego, California, (1990).
234 Hauschildt, S., Lückhoff, A., Mülsch, A., Kohler, J., Bessler, W.G., and Busse, R.:
Induction and activity of NO synthase in bone-marrow-derived macrophages are
independent of Ca²+. Biochem. J. 270, 351-356 (1990).
235 Hauschildt, S., Wolf, B., Uhl, B., Lückhoff, A., and Bessler, W.G.: Lipopeptide uptake and
signal transfer in leukocytes. In: Abstracts of the 10th Meeting of the European
Federation of Immunological Societies, Edinburgh, (1990).
236 Bessler, W. G., Kleine, B., Biesert, L., Schlecht, S., Schaude, R., Wiesmüller, K.-H.,
Metzger, J., and Jung, G.: Bacterial surface components as immunomodulators. In: K. N.
Masihi, W. Lange (eds.): Immunotherapeutic Prospects of Infectious Diseases,
Springer Verlag Berlin, 37-48 Heidelberg (1990).
237 Hauschildt, S., Wolf, B., Lückhoff, A., and Bessler, W.G.: Determination of second
messengers and protein kinase C in bone marrow derived macrophages stimulated with a
bacterial lipopeptide. Molec. Immunol. 27, 473-479 (1990).
238 Hoffmann,, P., Jimenez-Diaz, M., Loleit, M., Tröger, W., Wiesmüller, K.-H., Metzger, J.,
Jung, G., Kaiser, I., Stöcklin, S., Lenzner, S., Peters, J.H., Grimm, R., Schäfer, E. and
Bessler, W.G.: Preparation of human and murine monoclonal antibodies: antigens
combined with or conjugated to lipopeptides constitute potent immunogens for in vitro
and in vivo immunizations. Hum. Antibod. Hybridomas 1 (3) 137-144 (1990).
239 Scheipers, P., Bessler, W.G., and Hauschildt, S.: Lipopeptide induced B-lymphocyte
activation - transmembrane signalling mechanisms and role of G proteins. 6.
Frühjarstagung d. Gesellsch. f. Immunologie, Marburg, 28 (1990).
240 Kleine, B., Bessler, W.G., and Kettman, J.: Global analysis of membrane proteins: A way
to measure tumor differentiation. In: Abstracts of the International Society of Onco-
developmental Biology and Medicine, Moscow, USSR (1990).
241 Wiesmüller, K.-H., Metzger, J., Schaude, R., Beck, A., Hess, G., Haas, B., Bessler,W. G.
and Jung, G.: Synthetic low-molecular weight foot-and-mouth disease virus vaccine and
novel lipopeptides for the synthesis of immunogenic lipopeptide-antigen conjugates. In:
R. Epton (ed.): Innovation and Perspectives in Solid Phase Synthesis: Peptides,
Polypeptides and Oligonucleotides, Macro-organic Reagents and Catalysts. SPPC
Ltd., Kingswinford U.K., 601-607 (1990).
242 Scheipers, P., Bessler, W.G., and Hauschildt, S.: Lipopeptide induced leukocyte activation:
Transmembrane signalling mechanisms and role of G Proteins. In: Abstracts, 19th
Annual UCLA Symposia, Journal of Cellular Ciochemistry,155 (1990).
243 Loleit, M., Haas, G., Tröger, W., Wiesmüller, K.-H., Jung. G., Strecker, M., and Bessler,
W. G.: Synthetic lymphocyte activating lipopeptide conjugates with segments from HIV
proteins induce protein specific antibody formation. In: Abstracts des 3. Deutschen
AIDS-Kongresses, Hamburg (1990).
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22
244 Hauschildt, S., Mülsch, A., Lückhoff, A., and Bessler, W.G.: Nitric oxide formation and
nitrite release in bone marrow derived macrophages stimulated with bacterial mitogens.
In: The Macrophage, Fourth Symposium of the Upper Rhine Universities, Freiburg
(1990).
245 Wiesmüller, K.-H., Jung, G., Gillessen, D., Loffl, C., Bessler, W. G., and Böltz, T.: The
antibody response in BALB/c mice to the Plasmodium falciparum crircumsporozoite
repetitive epitope covalently coupled to synthetic lipopeptide adjuvant. Immunol. 72,
109-113 (1991).
246 Wolf, B., Uhl, B., Schwinde, A., Hauschildt, S., and Bessler, W.G.: Electron energy loss
spectroscopy as an alternative method to follow up the route of activators and drugs in
cells and tissues. In: Proceedings of the 12th International Congress for Electron
Microscopy, San Francisco, USA (1990).
247 Bessler, W.G., Sedelmeier,E., Loleit, M., Martinez-Alonso, C., Schlecht, S., und Jung, G.:
Bakterielle Oberflächenstrukturen als Immunmodulatoren. Allergologie 8, 309 (1990).
248 Hoffmann, P., Jimenez-Diaz, M., Loleit, M., Jung, G., Grimm, R., Schäfer, E., and Bessler,
W.G.: Antigens combined with or conjugated to lipopeptides constitute potent
immunogens for in vitro and in vivo immunizations and for the preparation of human and
murine monoclonal antibodies. Immunobiol. 181, 211 (1990).
249 Kleine, B, Bessler, W.G., Coutinho, A., and Kettman, J.: Using global analysis of
membrane proteins from WEHI 279.1 B-cells subclones co-expression of protein Groups
is revealed. Immunobiol. 181, 123-124 (1990).
250 Hauschildt, S., Hoffmann, P., Beuscher, H. U., Dufhues, G., Heinrich, P., Wiesmüller, K.-
H., Jung. G., and Bessler, W. G.: Activation of bone marrow-derived mouse macrophages
by bacterial lipopeptide: cytokine production, phagocytosis and Ia expression. Eur. J.
Immunol. 20, 63-68 (1990).
251 Bender, A., Schmidt, A., Bessler, W. G., Nain, M. and Gemsa, D.: TNF- production of
influenza A virus-infected macrophages: Temporally selective potentiation by bacterial
lipopolysaccharides (LPS) and lipoproteins. Immunobiol. 183, 247 (1991).
252 Müller, B., Hauschildt, S., Jung, G., Bessler, W. G. and Hoffmann, P.: Molecular
mechanisms of tumor cytotoxity and cytostasis induced in murine bone marrow-derived
macrophages by different synthetic analogues of bacterial lipoprotein. Immunobiol. 183,
308 (1991).
253 Bessler, W. G., Beck, P., Konetznick, U., Loleit, M., Sedelmeier, E., Hoffmann, P.,
Strecker, M. and Stöcklin, S.: Biological activity of bacterial surface components:
Immunogenicity and immunomodulatory properties of a bacterial extract from Escherichia
coli. Arzneimittelforsch./drug Research 41, 274-279 (1991).
254 Hoffmann, P., Müller, B., Körner, S., Höltje, J.-V., Wiesmüller, K.-H., Metzger, J., Jung,
G., and Bessler, W.G.: Cytostatic and cytotoxic activity of murine bone marrow-derived
macrophages stimulated with bacterial cell wall components and synthetic analogues.
Pathobiologie 59(4) 270 (1991).
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23
255 Metzger, J., Wiesmüller, K.-H., Schaude, R., Bessler, W. G. and Jung, G.: Synthesis of
novel immunologically active tripalmitoyl-S-glycerylcysteinyl lipopeptides as useful
intermediates for immunogen preparations. Int. J. Pept. Prot. Res. 37 (1), 46-57 (1991).
256 Uhl, B., Wolf, B., Schwinde, A., Metzger, J., Jung, G., Bessler, W. G., and Hauschildt, S.:
Intracellular Localization of a Lipopeptide Macrophage Activator: Immunocytochemical
Investigations and EELS Analysis on Ultrathin Cryosections of Bone Marrow-Derived
Macrophages. J. Leukocyte Biol., 50, 10-18 (1991).
257 Hauschildt, S., Lückhoff, A., Langhorne, J., Wiesmüller, K.-H., Jung, G., Bessler, W.G.,
and Cambier, J.C.: Increase in the intracellular free calcium concentration is not an
obligatory early event in lipopeptide-induced B Cell activation. Immunol. 73, 366-368
(1991).
258 Wiedemann, F., Link, R., Pumpe, K., Jacobshagen, U., Schäfer, H.E., Wiesmüller,
Hummel, R.P., K.-H., Tröger, W., Jung, G., Bessler, W.G., Böltz, T.: Histopathological
studies on the local reactions induced by complete Freund's adjuvant (CFA), bacterial
lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates. J. Pathol. 164,
265-271 (1991).
259 Uhl, B., Speth, V., Wolf, B., Bessler, W. G., and Hauschildt, S.: Rapid alterations in the
plasma membrane structure of macrophages stimulated with bacterial lipopeptides. In:
Abstracts, Deutsche Gesellschaft für Zell Biologie, Göttingen (1991).
260 Bessler, W.G., Haas G., Tröger, W., Wiesmüller. K.-H., and Jung, G.: Immune regulation
by synthetic lymphocyte activating lipopeptide conjugates: segments from HIV proteins
induce cefined isotype patterns in protein specific antibody formation. Midwinter
Conference of Immunologists, Asilomar (1991).
261 Hoffmann, P., Jimenéz-Dias, M., Müller, B., Richter, L., Strecker, M., Jung, G., and
Bessler, W.G.: Human monoclonal antibodies produced by primary in vitro immunization
with antigens combined with or covalently coupled to lipopeptides. Frühjahrstagung für
Immunologie, Berlin (1991).
262 Wolf, B., Hauschildt, S., Bessler, W. G. , Uhl, B., Dinger, V., Fiebig, H. H.: Subzelluläre
Mikropharmakokinetik von Immunmodulatoren und Cytostatika mittels analytischer
Elektronenmikroskopie. European Journal of Cell Biology, Supp. 32 (54), 79 (1991).
263 Bessler, W. G., Sedelmeier, E: In vivo assessment of the biological activity of bacterial
extract OM-89. In: Abstracts of the Symposium of the International Association of
biological Standardization, Annecy (1991).
264 Hauschildt, S., Mülsch, A., Scheipers, P., Busse, R., Bessler, W. G.: L929 murine
fibroblasts express a constitutive and a TNTa-induced calcium-calmodulin independent
nitric oxide (NO) Synthase. In: Abstracts of the Second International Meeting of the
Biology of Nitric Oxide, London (1991).
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24
265 Bessler, W. G.: Synthetic lipopeptide immunomodulators derived from bacterial
lipoprotein: Tools for the standardization of in vitro assays. In: Abstracts of the
Symposium of the International Association of Biological Standardization, Annecy
(1991).
266 Metzger, G., Jung, G., Bessler, W. G., Hoffmann, P., Strecker, M., Lieberknecht, A.,
Schmidt, U.: Lipopeptides containing 2-(Palmitoylamino)-6,7-bis(palmitoyloxy)heptanoic
Acid: Synthesis, Sterospecific Stimulation of B-Lymphocytes and Macrophages and
Adjuvanticity in vitro and in vivo. J. Med. Chem. 34, 1969-1974 (1991).
267 Müller, B., Hauschildt, S., Körner, S., Jung, G., Bessler, W. G. Hoffmann, P.: Murine bone
marrow-derived macrophages stimulated with synthetic analogues of bacterial lipoprotein
express several cytostatic and cytotoxic activities. In: Abstracts of the Fifth Annual
Conference of the Upper Rhine Universities, The Macrophage, Strasbourg (1991).
268 Müller, B., Hauschildt, S., Jung, G., Bessler, W. G., Hoffmann, P.: Molecular mechanisms
of tumor cytotoxicity and cytostasis induced in murine bone marrow-derived macrophages
by different synthetic analogues of bacterial lipoprotein. In: Abstracts of the 22nd
Annual Meeting of the Gesellschaft für Immunologie, (1991).
269 Kaufmann, H., Löffler, G., Bessler, W. G., Kleine, B.: Lipopolysaccharide-dependent
dephosphorylation in isolated lymphocyte Mmebranes. In: Abstracts für die erste
gemeinsame Frühjahrstagung der Gesellschaft für klinische und experimentelle
Immunologie, Berlin (1991).
270 Kaufmann, H., Löffler, G., Bessler, W. G., Kleine, B.: Protein dephosphorylation as
lipopolysaccharide induced signal transduction mechanism in murine macrophages. In:
Abstracts of the Fifth Annual Conference of the Upper Rhine Universities,
Strasbourg (1991).
271 Hauschildt, S., Scheipers, P. Bessler, W. G.: Inhibitors of poly(ADP-Ribose) polymerase
supress lipopolysccharide-induced nitrite formation in macrophages. Biochem. Biophy.
Res. Comm. 179, 865-871 (1991).
272 Hauschildt, S., Uhl, B., Wolf, B., Bessler, W.G.: Early events in lipopeptide-induced
macrophage activation. In: Abstracts of the 28th Annual Meeting of the Society for
Leukocyte Biology, Aspen (1991).
273 Hauschildt. S., Uhl, B., Wolf, B., Bessler, W.G.: Early Events in B Cell Activation In:
Abstracts of the 11th European Immunology Meeting, Helsinki (1991).
274 Uhl, B., Wolf, B., Bessler, W. G., and Hauschildt, S.: Intracellular localization of
lipopeptides in quiescent B-lymphocytes using EELS analysis. In: Abstrakts der
Frühjahrstagung der Deutsche Gesellschaft für Immunologie, Berlin (1991).
275 Bessler, W. G., Kleine, B., Martinez-Alonzo, C., Biesert, L., Strecker, M., Wiesmüller, K.-
H., Metzger, J. and Jung, G.: Biologische Aktivatät bakterieller Oberflächenkomponenten:
Bakterielle Extrakte und definierte bakterielle Zelloberflächenkomponenten als
Immunomodulatoren. In: Abstracts of the 11th European Immunology Meeting,
Helsinki (1991).
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25
276 Wiesmüller, K.-H., Bessler, W. G., Jung, G.: Solid phase peptide synthesis of lipopeptide
vaccines eliciting epitope-specific B-,T-helper and T-killer cell response. Int. J. Peptide
Protein Res. 40, 255-260 (1992).
277 Bessler, W. G.: Aids-Forschung: Neuer Ansatz zur Impfstoffentwicklung. Freiburger Uni
Magazin, 1 Feb., 16-17 (1992).
278 Hauschildt, S., Scheipers, P., Bessler, W. G., Mordvintcev, P., Vanin, A. and Mülsch, A.:
Nitric oxide production and ADP-ribosylation in macrophages. In: Abstracts of the
European Conference on Basic and Clinical Aspects of Macrophage Biology,
Regensburg (1992).
279 Hoffmann, P., Loleit, M., Jimenez-Diaz, M., Hass, G., Spohn, R., Ihlenfeldt, H.-G., Jung,
G., Bessler, W. G.: In vitro and in vivo immunization with lipopeptide-antigen-conjugates:
Mapping of B-cells epitopes with polyclonal and monoclonal antibodies. In: Abstracts of
the 23rd Annual Meeting of the Gesellschaft für Immunologie, Mainz (1992).
280 Bessler, W. G., Jung, G.: Bacterial immunoadjuvans: synthetic lipopeptides as novel
stimulants. In: Masseyeff et al. (eds.), Methods of Immunological Analysis, Vol. 2,
Chapter 3.8.2, Verlag Chemie, Weinheim (1992).
281 Hauschildt, S., Scheipers, P., Bessler, W. G. and Mülsch, A.: Inhibitors of Poly(ADP-
Ribose) Polymerase Suppress a TNF-J Inducible NO Synthase Isoform in L929 Cell. In:
Abstracts of the 23rd Annual Meeting of the Gesellschaft für Immunologie, Mainz,
(1992).
282 Hauschildt, S., Scheipers, P., Bessler, W.G., Mülsch, A.: Induction of nitric oxide synthase
in L 929 cells by tumor-necrosis factor- is prevented by inhibitors of poly(ADP-ribose)
polymerase. Biochem. J. 288, 255-260 (1992).
283 Kleine, B., Löffler, G., Kaufmann, H., Scheipers, P., Schickle, H., Westermeier, R.,
Bessler, W.G. Reduced chemical and radioactive liquid waste during electrophoresis
using polymerized electrode gels. Electropheresis 13, 73-75 (1992).
284 Bessler, W.G.: Synthetic lipopeptide immunomodulators derived from bacterial lipoprotein:
tools for the standardization of in vitro assays. Develop. Biol. Standard. 77, 49-56
(1992).
285 Seifert, R., Serke, S., Huhn, D., Bessler, W. G., Hauschild, S., Metzger, J., Wiesmüller and
K.-H., Jung, G.: Incomplete functional differentiation of HL-60 leukemic cells by
synthetic lipopeptides: partial inhibition by pertussis toxin of enhanced auperoxide
formation. Eur. J. Biochem. 203, 143-151 (1992).
286 Bessler, W. G. and Jung, G.: Synthetic lipopeptides as novel adjuvants. Res. Immunol.
143, 548-552 (1992).
287 Loleit, M., Haas, G., Ihlenfeldt, H. G., Jung, G., Müller, B., und Bessler, W. G.: Induktion
spezifischer T-Lymphozyten gegen Peptide der Reversen Transkriptase von HIV-1 mittels
synthetischer Lipopeptid-Peptid-Konjugate. In: Abstracts, 4 Deutscher Aids-Kongress,
Wiesbaden (1992).
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26
288 Bessler, W. G.: AIDS - Facts and Fantasy. In: Schülerzeitung des Kreisgymnasium,
Gundelfingen (1992).
289 Bessler, W. G.: Induktion einer spezifischen Immunantwort nach Immunisierung mit Uro-
Vaxom. Jatros Urologie - Nephrologie 8, 7-9, Frankfurt/Main (1992).
290 Hoffmann, P., Jiminéz-Diaz, Jung, G., Bessler, W. G.: Production of human monoclonal
antibodies: lipopeptide antigen mixtures or conjugates as tools for the primary in vitro
immunization of human peripheral blood lymphocytes. In: Second International
Conference on Human Antibodies and Hybridomas, Queens' College, Cambridge
(1992).
291 Bessler, W.G., Jung, G., Haas, G., Loleit, M.: T Cell-B Cell interactions in lymphocyte
activation with synthetic lipopeptide-peptide conjugates: activation of Th-cells and
induction of defined isotype patterns. In: Abstracts of the Fourth International
Conference on Lymphocyte Activation and Immune Regulation, Newport Beach
(1992).
292 Müller, B., Hoffmann, P., Mülsch, A., Bessler, W. G., Hauschildt, S.: Macrophage
mediated cytotoxicity. Role of nitric oxide in target cells In: Abstracts der 8.
Frühjahrstagung der Gesellschaft Für Immunologie, München (1992).
293 Uhl, B., Speth, V., Wolf, B., Jung, G., Bessler, W. G., Hauschildt, S.: Rapid alterations in
the plasma membrane structure of macrophages stimulated with bacterial lipopeptides.
Eur. J. Cell Biol. 58, 90-98 (1992).
294 Bessler, W. G.: Lipopeptide als Immunmodulatoren. In: Abstracts, 2. Kongreß der
Deutschen Gesellschaft für Krankenhaushygiene e.V., Erfurt (1993)
295 Bessler, W. G.: Lipopeptide als Immunomodulatoren. Med-Report, Blackwell
Wissenschafts-Verlag Berlin, 24:17 (1993).
296 Bessler, W. G., and Sedelmeier, E.: Biological activity of bacterial cell wall components:
Immunogenicity of an immunostimulating bacterial extract. Arzneim.-Forsch./Drug Res.
43 (I) 502-507 (1993).
297 Kleine, B., Edinger, Kammerer, R., Hoffmann, P., Bessler, W. G., von Kleist, S.: Isolation
and expansion of human tumour infiltrating B-lymphocytes from several colon
carcinomas. In: Abstrakts der 9. Frühjahrstagung der Gesellschaft für Immunologie,
Erlangen (1993).
298 Hoffmann, P., Wiesmüller, K.-H, Jung, G., Bessler, W.G.: Use of lipopeptide antigen
conjugates to enhance immunogenicity of low molecular weight antigens/haptens. In:
Cell & Tissue Culture: Laboratory Procedures. John Wiley & Sons, Ltd. Chichester
(1993).
299 Schlecht, S., Wiesmüller. K.-H., Jung, G., and Bessler, W. G.: Lipopeptide als natürliche
Adjuvantien für Impfstoffe aus Gram-negativen Bakterien. Naturwissenschaften 80, 9-17
(1993).
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300 Kleine, B., Edinger, M., Kaufmann, H., Bessler, W. G.: Synergistic activation of human B-
lymphocytes by anti-CD40 MAB, IL-4, and synthetic lipopeptides, but not
lipopolysaccharides. In: Abstrakts der 9. Frühjahrstagung der Gesellschaft für
Immunologie, Erlangen (1993).
301 Bessler, W. G., Beck, W., Wiesmüller, K.-H., and Jung, G.: Modulation of the immune
system by bacterial products: Hapten specific humoral immune responses induced by
lipopeptides conjugated to T helper cell epitopes. In: Abstracts of the International
Symposium on Immunotherapy of Infections, Berlin (1993).
302 Hoffmann, P., Jimenez-Diez, M., Schaude, R., Jung, G., Bessler, W. G.: Administration of
lipopeptide antigen conjugates in the form of immunocomplexes: a further improvement
in primary in vitro immunization of human peripheral blood lymphocytes. In: Abstracts
of the International Conference on Human Antibodies and Hybridomas III, San
Antonio (1993).
303 Bessler, W. G.: Lipopeptide als Immunmodulatoren. In: Proceedings der
Fortbildungsveranstaltung "Forschritte der Allologie und Immunologie" Davos,
Blackwell Wissenschafts-Verlag GmbH, Berlin (1993).
304 Bessler, W. G.: Induktion einer Bakterien-spezifischen Immunantwort durch einen
immunstimulierenden bakteriellen Extrakt (IBEc). Urologe B 33, 323-325 (1993).
305 Kreutz, M., Riedel, D., Ackermann, U., Hauschildt, S., Bessler, W. G., Andereesen, R.:
Synthetic lipopetides are potent stimuli of the cytokine repertoire in human monocytes
and monocyte-derived macrophages. Blood 82,10 (1993).
306 Beck W., Benz, I., Bessler, W. G., Jung, G., Kohlhardt, M. : Responsiveness of cardiac Na+
channels to a site-directed antiserum against the cytosolic linker between domains III and
IV and their sensitivity to other modifying agents. J. Membrane Biol. 134, 231-239
(1993).
307 Bessler,W. G.: Establishing a cell culture laboratory. In: Methods and Applications of
Single Cells and Cell Cultures in Physiology and Pharmacology, Biomeßtechnik-
Verlag, March (1993).
308 Metzger, J. W., Sawyer, W.H., Wille, B., Biesert, L., Bessler, W. G. and Jung, G.:
Interaction of immunologically-active lipopeptides with membranes. Biochim. Biophy.
Acta 1149, 29-39 (1993).
309 Hauschildt, S., Bessler, W. G., Uhl, B., Wolf, B.: Role of synthetic bacterial lipopeptides in
leukocyte activation. In: Abstracts of the 3rd International Congress on the Immune
Consequences of Trauma, Shock and Septis Mechanisms and Therapeutic
Approaches, München (1993).
310 Bessler W. G.: Lipopeptide als Immunmodulatoren. In: Abstracts der
Fortbildungsveranstaltung"Forschritte der Allergologie und Immunologie", Davos
(1993).
311 Bessler W. G.: Lipopeptide als Immunomodulatoren. In: Abstrakts des Symposiums
Fortschritte der Allergologie und Immunologie, Davos (1993).
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28
312 Bessler, W. G., Beck, W., Uhl, B., Müller, B., Hoffmann, P., Wiesmüller, K.-H., and Jung,
G.: Enhanced hapten specific humoral immune response induced by lipopeptide-hapten-
conjugates attached to T helper cells epitopes. In: Abstracts of the 24th Annual
Meeting of the Gesellschaft für Immunologie, Leipzig (1993).
313 Bessler, W. G. and Jung, G.: Lipopeptide based vaccines. In: Abstracts of the Second
International Conference on Vaccines: New Technologies & Applications,
Alexandria, VA., USA (1994).
314 Hauschildt, S., Scheipers, P.,and Bessler, W. G.: Lipopolysaccharide-induced change of
ADP-ribosylation of a cytosolic protein in bone-marrow-derived macrophages. Biochem.
J. 297, 17-20 (1994).
315 Hauschildt, S., Bessler, W.G., Uhl, B., Wolf, B.: Synthetic lipopeptides derived from
bacterial lipoprotein and their interactions with immune cells. Trauma, Shock and
Sepsis, 3:2-5 (1994).
316 Maltsev, V. A., Karimov, D.P., Ataullakhanov, R.I., and Bessler, W. G.: Patch-clamp
studies of membrane condactance upon B cell activation induced by lipopolysaccharide, a
synthetic lipopeptide analogue of bacterial lipoprotein and a new plant immunostimulant
vitan. Phys. Chem. Biol. & Med. 1(2), 127-135 (1994).
317 Kleine, B., Rapp, W., Wiesmüller, K.-H., Edinger, M., Beck, W., Metzger, J.,
Ataullakhanov, R., Jung, G., and Bessler, W. G.: Lipopeptide-Polyoxyethylene-
Conjugates as Mitogens and Adjuvants. Immunobiol. 190, 53-66 (1994).
318 Erhard, M.H., Kellner, J.,Bessler, W. G., and Lösch, U.: Ein Lipopeptid als Adjuvans zur
Immunisierung von Hühnern. Biochemica Information, Boehringer Mannheim 94
(1994)
319 Loleit, M., Deres, K., Wiesmüller, K.-H., Jung, G., Eckert, M., and Bessler, W. G.:
Biological activity of the E.coli lipoprotein: detection of novel lymphocyte activating
peptide segments of the molecule and their conformational characterization. Biol. Chem.
Hoppe-Seyler 375, 407-412 (1994).
320 Beck, W., Jung, G., Bessler, W. G., Benz, I., Kohlhardt, M.: Conformational mapping of
the cytosolic linker between domains III and IV of the cardiac Na+ channel protein and
binding studies with a site-directed channel modifying antibody. Biochimica et
Biophysica Acta 1206, 263-271 (1994).
321 Bessler, W. G.: Unspezifische Immunstimulation: Lipopeptid-Analoga des bakteriellen
Lipoproteins als Adjuvantien/non-specific immunostimulation: lipopeptide analogues of
bacterial lipoprotein as adjuvants. Hyg. Med. 19: 396-403 (1994).
322 Hauschildt, S., Beuscher, H. U., Jung, G., Bessler, W. G., Ulmer, A.: Intraperitoneal
injection of synthetic bacterial lipopeptides does not cause a rise in circulating
inflammatory cytokines. FEMS Immunol. Med Microbiol. 8, 77-82 (1994).
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323 Edinger, M., Bessler, W. G., and Kleine, B.: Synergistic stimulation of human B
lymphocytes by anti-CD40 monoclonal antibodies and synthetic lipopeptide analogues
from E.coli lipoprotein. Immunology 81, 205-210 (1994).
324 Bessler, W. G., Müller, B., Uhl, B., Heinevetter, L., Beck, W., and Jung, G.: Bacterial
lipopeptides as leukocyte activators and adjuvants in LPS responder and nonresponder
mice. In: Abstracts der XXV Tagung der Gesellschaft für Immunologie, Konstanz,
(1994).
325 Bessler, W. G., Müller, B., Uhl, B., Kleine, B., Beck, W., and Jung, G.: Bacterial
lipopeptides as leukocyte activators and adjuvants in LPS responder and nonresponder
mice. J. Endotox. Res. 1:60 (1994).
326 Kleine, B., Baumgartner, A., Müller, B., Bessler, W..G., IgG positive, IgM negative
memory cells in human tonsils are strongly CD38/CD71 positive and CD23 negative. In:
Abstracts der 10. Frühjahrstagung der Gesellschaft für Immunologie, Heidelberg
(1994).
327 Hoffmann, P., Skibinski, G., Wiesmüller, K-H., Ihlenfeldt, H.G., Jung,G., Bessler, W.G.,
and James, K.: In vitro activation of human B lymphocytes using three-dimensional tissue
explants of lymphoid organs. In: Abstracts der 10. Frühjahrstagung der Gesellschaft
für Immunologie, Heidelberg (1994).
328 Bessler, W. G.: Synthetic lipopeptide conjugates constitute efficient novel immunogens and
vaccines. In: Abstracts, Cold Spring Harbor Conference "Molecular Approaches to
the Control of Infectious Diseases", New York: 45 (1994).
329 Bessler, W. G., Beck, W., Wiesmüller, K.-H., Jung. G.: Modulation of the immune system
by bacterial products: hapten-specific humoral immune responses induced by lipopeptides
conjugated to T helper cell epitopes. In: Masihi (ed.) Immunotherapy of Infections, pp
329-338, Marcel Dekker, Inc., New York (1994)
330 Mattner, E. Bessler, W. G., Simon, M. M. and Alber, G.: Induction of interleukin-12 (IL-
12) by different microbial species and isolated cell wall compounds. Abstract, 11.
Füh