Welcome toIntroduction to Bioinformatics

Monday, 23 January 2012

Introduction to Molecular Biology

What do we talk about?

Determined by Questionnaires

Fraction of participants handing in questionnaires

Fraction of participants active on BioBIKE

Your Questions…how to submit problem sets. Do we type up our responses separately and email them to you, submit them on Blackboard, or print and bring them to class?

I would like E and F

explained better

Study Question 6

Pick out the polymers… which organism specific?

Questionaire II.C

How do lipids self-assemble?

Study Question 5

Identify the protein in

Strategies of Life

Study Question 8Why isn't glycogen as varied as protein?

Study Question 11How do genes exert control over cellular processes?

Study Question 12How does entire the protein determine chymotrypsin function?

Questionaire IV.HWhat does all this have to do with bioinformatics?

Proteins

Study Question 13How does glycophorin enter a membrane?

Study Question 14What kinds of mutations affect protein functions?

Study Question 6

Pick out the polymers… which organism specific?

Questionaire II.C

How do lipids self-assemble?

Study Question 5

Identify the protein in

Strategies of Life

Why?

Study Question 4 What is an example of a household item that is hydrophobic

Study Question 5

Identify the protein in

Study Question 13

How do proteinsenter membranes?

I want to have a step by step understanding of how the lipids in soap interact with grime on our bodies

and wash away with water.

Study Question 4 What is an example of a

household item that is hydrophobic

Finger

Water

Finger

Water

Finger

Water

Finger

Water

Information+

Self-assembly

Structure+

Function

ProteinDNA

CGACCATCGCCTTAGTAC

Study Question 11

How do genes exert control over cellular processes?

Study Question 12

If the critical part of an enzyme is its active site, what's the use of the rest of the protein?

Study Question 12

If the critical part of an enzyme is its active site, what's the use of the rest of the protein?

Gly-193

Asp-102

Ser-195

His-57

Study Question 12

If the critical part of an enzyme is its active site, what's the use of the rest of the protein?

Gly-193

Asp-102

Ser-195

His-57

Study Question 12

If the critical part of an enzyme is its active site, what's the use of the rest of the protein?

Gly-193

Asp-102

Ser-195

His-57

http://library.thinkquest.org/C004535/cell_membranes.html

How does a membrane form?

Study Question 13How did glycophorin A gain its proper

position in the red blood cell membrane.

How does protein get inside?

Study Question 13How did glycophorin A gain its proper

position in the red blood cell membrane.

Study Question 13How did glycophorin A gain its proper

position in the red blood cell membrane.

Study Question 13How did glycophorin A gain its proper

position in the red blood cell membrane.

Study Question 13How did glycophorin A gain its proper

position in the red blood cell membrane.

Study Question 14

What kind of change in the amino acid sequence of a protein might cause it not to work?

Questionnaire IV.H

What does all this have to do with bioinformatics?

Information+

Self-assembly

Structure+

Function

ProteinDNA

CGACCATCGCCTTAGTAC

Study Question 11

How do genes exert control over cellular processes?

Structure

TranscriptomicsSystems

GenomicsTCTACTTATA TTCAATCCAC AGGGCTACACAAGAGTCTGT TGAATGAACA CATACATGGTTTCTGTCTGC TCTGACCTCT GGCAGCTTTC TGGATTTCGG AACTCTAGCC TGCCCCACTC GAACCTTAGT GACTTCTGCT ATACCAAAGT CTCCGTAAAC CTCTAACATG ATGTCAGCAA TGAATAAACT TTGTTAAAGG TACAAATGAA AAGAGTTTAA AGTTAAAAAC GAATTGCAGT AAACCTGTAT GGTTACATGA ACTGCCTAAA TTATATATTT TAAGAAATTA ATTGCAATTA CCCCAGCTGT CATTAAAAAG AGGCAAATAC GACAGCACTG ACCCTCAAGA AGGCACCGGC GCTGAAATTC CGCTGAGAGC AGAGTGGTAC CCCTGCACCA GGTCTTTCCT GTGGGCACTG ATGAATGACT GAACGAACGA TTGAATGAAA

Metabolomics

Proteomics

What does this have to do withbioinformatics?

TGAGACACATATTTTTGATATTCCAGTTGTTGCAATCGAATGTAAAACATATTTAGATCTTTAAATGTATGGTACATTCAAGATCCAACCTTCATTCTAGTGTTTAAAGAGAACTGATTTGTTTGCAGGGGCAGGAGGCTTTGGTTTAGGTTTTG

AAATGGCAGGCTTCTCTGTACCTTTATCTGTTGAAATTGATACCTGGGCTTGTGATACACTACGCTACAACCGCCCTGATTCAACAGTTATTCAAAATGATATCGGTAACTTTAGTACAGAAAATGACGTTAAGAATATCTGCAACTTTAAACCTGATATTATTATTGGCGGGCCTCCATGCCAGGG

ATTTAGTATTGCTGGGCCAGCCCAAAAAGATCCTAAAGATCCTAGAAATGGAATTATCAAACAAATCATATGATCAGAATAATCGCCGTTTAAATCCTCATAAAACTTTTATTCATCAACTTTGCACAATGGATAAAATTTCTTGAACCTAAAGCGTTTGTCATGGAAAACGTAAAAGGATTGCTATCAAGGAAAAATGCAGAAGGTTTTAAAGTTATAGATACTTCTCACTAAATATAAAGATTTTTTAGATCAGCAGCATTATGCAGAAAAATTTGATTCAAGACGACGGTACTGGTTTAACCAGCCAAATGTTCTTTCTACTACCCACCGTTTGGGCAAAACCTTTATTAAGAAAACATTTGAAGAACTTGGTTATTTTGTCGAAGTATGGGTTTTAAATGCTGCGGAATATGGCATTCCGCAAATTAGAGAACGTATTTTTATTGTTGGCAATAAAAAAGGTAAAGTACTAGGTATGAGTATTATACCTGCACTAACTTTGTGGGACGCAATATCAGACTTACCAGAACTTAATGCGCGTGAAGGAAGTGAAGAGCAACCCTATCATTTAAAACCTCAAAATACTTATCAGACTTGGGCTAGAAATGGTAGTGCTACGCTTTACAATCATGTTGCAATGGAACATTCTGACCGTTTAGTAGAACGTTTCCGGCATATAAAATGGGGTGAATCCAGTTCGGATGTATCTAAAGAACATGGAGCTAGACGACGTAGTGGTAATGGTGAATTATCAAACAAATCATATGATCAGAATAATCGCCGTTTAAATCCTCATAAACCGTCTCACACTATTGCTGCGTCATTCTATGCTAATTTTGTCCATCCTTTTCAACATCGAAATTTAACAGCCCGTGAAGGAGCTAGAATCCAATCTTTTCCAGATAACTATAGATTTTTTGGAAAAAAAACTGTCGTATCTCATAAACTATTGCATCGAGAAGAAAGATTTGATGAAAAATTTCTTTGTCAATATAATCAAATCGGTAATGCTGTACCCCCTCTTCTCGCTAAAGTAATTGCACATCATCTTCTAGAGAAATTAGAGTTATGCCAACAACTGATAGAAATCCTCTAGTGCATGGATCAAATCTTGAACAAAAAGAGAATCATCGTACAAAATACAGAGATACTGAAAGCAGGACTTTCCTTAGAGAAA TCAGAACTGAATATGACAAATGGCATAAAGCAAATATGAACCTGGTTGGACCAAAATCAGAAATTACTGACCAAGATGATTCAATTATTACTCAAAGAGTGGAACTTCTCACTAAATATAAAGATTTTTTAGATCAGCAGCATTATGCAGAAAAATTTGATTCAAGATCCAACCTTCATTCTAGTGTTTTAGAGACCATTTATAAAGTAAATCTTTAGACGACTAGACGACGTAGCATAATACGAGTCATAACGGCATATATGGCAGCCTCACTCATTTCTGGGAGACGCTCATAATCCTTACTGAGACGACGGTACTGGTTTAACCAGCCAAATGTTCTTTCTACTACCCACCGTTTGGGCAAAACCTGAAATTCTTGATTAGTACGCCGGATTACCTCAACATGAGCTTGAATCATCAGCCAAACAGAGAGCGCAAATTTATCACCGTCATAGCCGGAATCAACCCAGATGACTTCAACTTTTTCCAGTAATTCTGGACGCTCTTCTAACAGTTCCATCAAAGTATAGGCGGCAAGTAATCTTTCTCCAGCATTTGCTTCACTTACAACCACTTTTAACAAAAGTCCCAGACTATCAACCAAAGTTTGCCGCTTTCGTCCTTTTACCTTCTTGCCACCATCAAAACCGTACACATCCCCCTTTTTTCAGTCGTTTTTACCGACTGGCTGTCTGCCGCGATCGCCGTGGGTTGAGTTGACTTCCCCATTTTTTGACGAACTTGATCGCGCAAAGTATGATTCATTTCAGTTGAACTAGGAGGAAAATCCCCTGGAAGCATATCCCACTGACAACCTGTTTTCAGATGGTAGTAGATAGCGTTGCATACTTCTCGCATATCAGTTGTTCGGGGATGCCCACCGCATTTAGCGGGTGGAATCAAAGGAGCTAAAATTGCCCATTCTGAGTCATTAAGGTCTGTAGAATAAGACTTTCGTCTCATTGTTTCCTATGTAAATACACTCTACAAACAGTATCTTATCGCT

GCCTTTTTATCTTAGCTCTCCTTTAGATTTACTTTATAAATAGCCTCTTAGAAGAATTTCTTTATTATTTATTTAAAGATTTAGTACAAGATTTCGGGCAGAACGCTCTTATTGGTAAGTCACACACGTTCAAAGATATTTTCTTCGTACCACCAAAATATTCTGAAATGCTCAAGCGACCTTATGCGCGAATTGAGAGAAAAGATCATGATTTCGTAATTGGTGCAACTGTTCAAGCATCGCTTGAAGCAGCACCTCCTCCAGAACAAAACCA TGCTTGAGGGATCTTCACGCGCAGCAGAGGATTTAAAAGCGAGAAATCCTAACAGTTTATACCTTGTGGTTATGGAATGGATAAAACTGACCAATGATGTAAATTTACGAAAATATAAAGTTGATCAAATTTATGTACTACGTCAGCAAAAAAATACTGATAGAGAGTTTAGGTATGAGTCAACTTACATAAAAAAT

What isbioinformatics?

Michael MontagueJ Craig Venter Institute

Wednesday, January 26, 12:30(12:15 food)

Engineering West Building, Room 401

Science (17 Dec 2010) 330:1605

IV.G. How a greater ability to predict protein function from its primary structure would change the world we live in

Study Question 1What at root do enzymes control?