Welcome to Immunology Course

IMMUNOLOGY

Prof. dr Vera PravicaProf. dr Dušan PopadićDoc. dr Miloš MarkovićAssist. dr Emina Savić

imunologija@med.bg.ac.rs

Tel. 3643-236Facebook: Antitelija Limfocitic

Advice

• for successful learning• and passing the exam

Immunology

Lectures (15)

Labs (10)

Seminars (20)

• independent subject (separated from Microbiology)• winter semester• 45 hours during 15 week

Seminars, Labs and Lectures are integral parts of the course

Student are allowed to be absent on seminar or lab twiceduring the semester

Textbook

Basic Immunology: Functions and Disorders of the Immune System- Authors: Abbas AK, Lichtman AH.- Publisher: Elsevier- 3rd edition updated, 2011

.ppt presentations and authorised supplementary material (available on web site)

Activity during the course (seminars, labs and lectures) through activity points

Continuous assessment

Colloquium – divided in three separate mini-tests after every 4 weeks (5th, 9th and 13th week)

Presence on lectures noted separately

Final test

Test (multiple choice – 1 correct answer out of 4)

- first: in the 5th week (first 4 chapters from the textbook)

- second: in the 9th week (chapters 5 to 8)

-third: in the 13th week (chapters 9 to 12 plus immunological methods and vaccines)

Colloquium

15 minutes per mini test

It consists of 30 questions in total (divided into 3 mini tests with 10 questions each)

1 point for each correct answer (max 30 points)

Threshold for passing the final test is 36 points (50% plus 1)

Final test

70 points in total

consists of:

• 20 multiple choice questions with one correct answer out of four (2 points for each correct answer, max. 40 points)

• 5 fill-in questions where correct word should be filled in the blanks (max. 20 points)

• 2 questions that require short answers up to five sentences (max. 10 points)

Final mark in Immunology

For the passing of the Immunology exam the minimum of 51 points (out of 100) should be collected on condition that the 50% of points plus one (minimally 36) has been reached in the final test

Note: If the student collected less than 15 points in colloqium (i.e. 50%), he/she must perform better than 36 in the final test

100 points in total

51-60 6 (six)61-70 7 (seven)71-80 8 (eight)81-90 9 (nine)91-100 10 (ten)

Activity points (max. 10 points) are added only if the minimum of 51 points has been reached

Introduction to immune system

• Innate and adaptive immunity• Types of adaptive immunity• Properties and phases of adaptive

immune response• Central and peripheral lymphoid organs• Lymphocyte recirculation

IMMUNITY

INNATE

(Natural)

(Native)

ADAPTIVE

(Aquired)

Principle mechanisms of innate and adaptive immunity

Principle mechanisms of innate and adaptive immunity

The most important cells of the immune system

Chain of events in infection

Pathogen(s) enter(s) tissue

Pathogen(s) enter(s) tissue

Pathogen(s) enter(s) tissue

Macrophages recognize (and eliminate) pathogens

Macrophages recognize (and eliminate) pathogens

Macrophages recognize (and eliminate) pathogens

Inflammation is induced and PMNs attracted

Inflammation is induced and PMNs attracted

Antigen-presenting cells (APCs) capture antigen(s)

Antigen-presenting cells (APCs) capture antigen(s)

APCs migrate to draining lymph node

APCs migrate to draining lymph node

APCs migrate to draining lymph node

APCs migrate to draining lymph node

APCs migrate to draining lymph node

APCs migrate to draining lymph node

APCs migrate to draining lymph node

APCs migrate to draining lymph node

APCs migrate to draining lymph node

T cells are activated by APCs

T cells are activated by APCs

T cells are activated by APCs

B cell are activated (helped by T cells)

B cell are activated (helped by T cells)

B cell are activated (helped by T cells)

Activated B cells (plasma cells) produce antibodies (Abs)

Activated B cells (plasma cells) produce antibodies (Abs)

Activated B cells (plasma cells) produce antibodies (Abs)

Activated B cells (plasma cells) produce antibodies (Abs)

Activated T cells and Abs leave lymph node...

... enter blood stream and...

... enter blood stream and...

... migrate to site of infection

... migrate to site of infection

... migrate to site of infection

Activated T cells stimulate phagocytes

Activated T cells stimulate phagocytes

Activated T cells stimulate phagocytes

Activated T cells stimulate phagocytes

Abs neutralize pathogens and stimulate phagocytes

Abs neutralize pathogens and stimulate phagocytes

Abs neutralize pathogens and stimulate phagocytes

Abs neutralize pathogens and stimulate phagocytes

Abs neutralize pathogens and stimulate phagocytes

http://instruction.cvhs.okstate.edu/vmed5253/immunobiology.swf

Pathogen is eliminated

Principle mechanisms of innate and adaptive immunity

Mechanisms of adaptive immunity

- acquired throughout a lifetime of an individual

- result of previous contact with pathogen

- present in vertebrates

Properties of adaptive immunity

- diversity and specificity

- memory

- clonal expansion

- autotolerance

- specialization

- stimulation of mechanisms of innate immunity

Types of adaptive immunity

Phases of adaptive immune response

Types of lymphocytes

Lymphoid organs

Lymph node structure

Lymph node structure

Recirculation of T lymphocytes

The morphology of the spleen

Introduction to immune system

• Innate and adaptive immunity• Types of adaptive immunity• Properties and phases of adaptive

immune response• Central and peripheral lymphoid organs• Lymphocyte recirculation

lymph nodes, spleen and MALTj.Primary adaptive immune response begins in

10.

peripheral lymphoid organsi.Human peripheral (secondary) lymphoid organs are

9.

epithelial barriersh.Human central (primary) lymphoid organs are

8.

early defence against infectious agents

g.Important properties of adaptive immune cells are

7.

bone marrow and thymusf.Types of adaptive immunity are6.

diversity, specificity and memorye.Cells of adaptive immunity are5.

natural or native immunityd.Cells of innate immunity are4.

B and T lymphocytes c.First line of defence of innate immunity is provided by

3.

humoral and cellular immunityb.Mechanisms of innate immunity mediate

2.

phagocytes and NK cellsa.Innate immunity is also called1.

1._____ 2._____ 3._____ 4._____ 5._____ 6._____ 7._____ 8._____ 9._____ 10.____d. g. h. a. c. b. e. f. j. i.