Weekly Roundup

June 4, 2012 Volume 4, Number 21

In This Issue

Good News

Make a Note of it

Events

Seminars

Undergraduate Students

Graduate Students

Position Announcements

Notices for the Weekly Roundup

If you have information to include in the Roundup, send all information (i.e., who, what, when, where and why to Kim Dobson (dobsonk@msu.edu).

Seminars will be posted the week preceding and the week of the seminar. Thank you for your cooperation

GOOD NEWS

MAKE A NOTE OF IT

Change in Monday Morning Roundup

You may have noticed the change in the ANS Monday Morning Roundup. The Department Advisory Committee has met and made a few changes to the format of the weekly newsletter. The new name Weekly Roundup reflects the newsletter will be sent out the first of the week along with seven categories listed in the left column. Please be sure to submit information you would like included no later than 9:00 a.m. on Mondays to guarantee publishing in the upcoming newsletter. Please send to Kim Dobson, dobsonk@msu.edu

WEBINAR International Symposium on Beef Cattle Welfare June 6th 10:30 - 6:30 EST June 7th 10:30 - 2:30 EST 162 Food Safety and Toxicology - MSU http://www.beefwelfare2012.ca This live webinar is by the sponsored MSU CVM Food Systems Fellowship Program (cvm.msu.edu/fsf). You are welcome to attend all or parts of the webinar. You can view the entire program at www.beefwelfare2012.ca. There is no charge. The webinar will be in 162 Food Safety and Toxicology (http://maps.msu.edu/interactive/). For more information, please contact Dan Grooms groomsd@cvm.msu.edu.

Travel Tip

When submitting travel for reimbursement 90 days past the date of a trip, traveler must submit a letter explaining why submission was not turned in before the 90 day deadline (per MSU travel office). The letter will need to be signed by Dr. Janice Swanson and once reimbursement is submitted it will also be routed to the Dean’s office for approval.

Biosecurity At Our Farms With the summer season here and more people traveling internationally, it is a good time to think about the importance of biosecurity at our farms. Please pay attention to and remind others of the

"STOP" sign warnings and biosecurity protocols at our farms. To help protect our farms, if you or others have been out of the country in the past 7 days please contact the Farm Manager before going out to the farms or refrain from going out to the farms for at least 7 days after returning from another country. Please inform students, friends, family, and international visitors of this policy as well. If you are aware of international visitors planning to visit MSU through another hosting faculty or organization, please communicate this policy to them prior to their visit. The reason for this policy is to reduce the risk of accidently bringing a potentially devastating foreign animal disease, such as Foot and Mouth Disease, into our United States livestock operations. Thanks for helping us protect our livestock. If you have questions, contact Larry Chapin, Ted Ferris or Dan Grooms.

EVENTS

Departmental Breaks Below is the schedule for the Department coffee breaks. They will be held once a month in room 1310 Anthony at 9:30. Please be sure to stop by and enjoy doughnuts/bagels and coffee with your colleagues. June – None July – None August – None September 14

SEMINARS

Marcelo Demarchi Goissis will present his PhD defense, "Functional studies of CT4, SOX2 and CDX2 in the bovine pre-implantation embryo" June 7th, 9AM, room 1240, Anthony Hall.

Wei Yan, M.D. Ph.D., Associate Professor, University of Nevada School of Medicine will present “Regulation of spermatogenesis: from Genetics to Epigenetics” in room 1415 Biomed Physical Science Building on June 4, 2012 from 4:00-5:00.

UNDERGRADUATE STUDENTS

MSU Gerstacker Entrepreneurial Grant Program Four Animal Science undergraduate students (Caroline Ylioja, Claire Vanderson, Jessica Vidlund, and Nicole Martinec) were recently selected as receipients for the 2012-2013 MSU Gerstacker Entrepreneurial Grant Program. The students will receive receive financial support as they work to develop a business plan using snack food by-product in the diet of starter pigs. This project will be conducted as part of the ASURSA club under the guidance of Nathalie Trottier and Liz Karcher. The students worked incredibly hard and are well deserving of this award.

GRADUATE STUDENTS

POSITION ANNOUNCEMENTS

Dr. Wei Yan, Associate Professor Department of Physiology and Cell Biology University of Nevada School of Medicine Sunday, June 3, 2012, Grand Rapids, MI

2:23 p.m. Arrive Grand Rapids, Gerald R. Ford Airport on United Airlines Flight # 0921. Ed Dean with W. MI Sedan Svc. will meet you in the Concourse area. Contact: 616-821-4924 Ed’s cell. Housing at Amway Grand Plaza. 187 Monroe Ave NW, Grand Rapids, MI 49503. Contact: 616-776-6455. Hotel Confirmation # 10Y3MC (one night)

4:00-6:30 p.m. Travel with Dr. Asgerally Fazleabas. Professor and Associate Chair of Research, Department of Obstetrics, Gynecology & Reproductive Biology. Tour Grand Rapids. Contact: Dr. Fazleabas 630-915-8054 Cell.

6:30-8:30 p.m. Dinner with Dr. Richard Leach, Dr. John Risinger, Dr. Asgerally Fazleabas, Dr. JaeWook

Jeong. Meeting Location: Charley’s Crab 63 Market Avenue Southwest Grand Rapids, MI 49503, Ph: 616-459-2500. Reservation under: Dr. Fazleabas (5 people)

8:30 p.m. Travel with Dr. Asgerally Fazleabas back to the Amway Grand Plaza.

Monday, June 4, 2012, Grand Rapids, MI

8:00 a.m. Travel with Dr. Asgerally Fazleabas to Van Andel Institute (VAI) 333 Bostwick Ave NE, Grand Rapids, 49503. Contact: Dr. Fazleabas 630-915-8054 Cell.

8:00-8:45 a.m. Meet Bryn Eagleson, Vivarium Director, Mouse Transgenic Core, Van Andel Institute for overview of vivarium and tour. Contact: 616-234-5260.

8:45-9:30 a.m. Tour lab space. Location: Van Andel Institute

9:30-10:00 a.m. Meet Dr. John Risinger, Associate Professor, Director, Division of Reproductive Biology , Department of Obstetrics, Gynecology & Reproductive Biology. Location: Van Andel Institute, Room 4029. Contact: 616-234-0989

10:00-10:30 a.m. Meet Dr. JaeWook Jeong, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Biology. Location: Van Andel Institute, Room 4029. Contact: 616-234-0987.

10:30-11:00 a.m. Meet Dr. Sangeeta Devi Yendrembam (Y. Sangeeta Devi), Assistant Professor,

Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University. Location: Van Andel Institute, Room 4029. Contact: 616-234-0988.

11:00-11:30 a.m. Meet Dr. Ying Chen & Dr Kai Wang, Assistant Professors, Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University. Location: Van Andel Institute, Room 4029. Contact: Dr. Chen 616-234-5793, Dr. Wang 616-234-0986

Dr. Wei Yan Itinerary Grand Rapids and East Lansing, Michigan

Reproductive and Developmental Sciences Program

Dr. Wei Yan, MSU Itinerary Page 2 of 4

11:30 a.m. Travel with Dr. Asgerally Fazleabas to East Lansing

Monday, June 4, 2012 - East Lansing, Michigan

1:15 p.m. Arrive East Lansing with Dr. Agerally Fazleabas

1:15--2:30p.m. Lunch with Dr. Asgerally Fazleabas and Dr. George Smith, Professor of Animal Science and Physiology. Location: 1230 Anthony Hall. Tour Lab Space in Anthony Hall. Contact: Dr. Fazleabas 630-915-8054, Dr. Smith 517-881-0713.

2:30-3:30 p.m. Meet with RDSP Cluster Hire Search Committee: Dr. Jose Cibelli, Dr. Susan Conrad, Dr.

Asgerally Fazleabas, Dr. Jason Knott, Dr. David Kreulen, Dr. John Risinger, Dr. George Smith and Dr. Karen Patricia Williams. Location: 1240 Anthony Hall.

3:30-4:00 p.m. Seminar Preparation 1415 Biomedical and Physical Sciences (BPS) 4:00-5:00 p.m. Presentation: Regulation of Spermatogenesis: From Genetics to Epigenetics.

Location: 1415 BPS 6:00 p.m. Dinner with Dr. Jason Knott, Dr. James Ireland and Dr. Richard Pursley. Location:

Riverhouse Inn, 310 West Grand River Avenue Williamston, MI 48895, (517) 655-4300

Tuesday, June 5, 2012, East Lansing, MI

7:30-8:30 a.m. Breakfast with members of the RDSP Executive Committee Dr. John Baker, Dr. David Kreulen, Dr. Richard Leach, Dr. Janice Swanson and Dr. Joseph R. Haywood. Location:

Kellogg Hotel and Conference Center.

8:45-9:15 a.m. Meet Dr. George Smith, Professor of Animal Science, 1230G Anthony Hall. Contact:517-

432-6178. 9:15-10:00 a.m. Meet Dr. Sheba Mohankumar, Assistant Professor of Pharmacology & Toxicology,

College of Veterinary Medicine. Location: 1240 Anthony Hall

10:00-10:45 a.m. Meet Dr. Chengfeng Yang, Assistant Professor, Physiology, College of Veterinary Medicine Resources. Location: 4171 BPS. Contact: 517-884-5153

10:45-11:30 a.m. Meet Dr. David Arnosti, Professor, Department of Biochemistry & Molecular Biology

Location: 413 Biochemistry. Contact: 517-432-5504. 11:45-12:45 p.m. Lunch with Dr. James Ireland Professor of Animal Science. Location: TBD Contact:

517-432-1384.

1:00-1:45 p.m. Meet Dr. Jason Knott, Assistant Professor of Animal Science. Location: 1230H Anthony Hall Contact: 517-432-5446 Office

1:45-2:30 p.m. Meet with Dr. Jose Cibelli, Professor of Animal Science. Location: B270 Anthony Hall

Contact: 517-432-9206

2:30-3:30 p.m. Prepare for Chalk Talk. Location: 1240 Anthony Hall

3:30-4:30 p.m. Chalk Talk with RDSP Cluster Hire Search Committee: Dr. Jose Cibelli, Dr. Susan Conrad, Dr. Asgerally Fazleabas, Dr. Jason Knott, Dr. David Kreulen, Dr. John Risinger, Dr. George Smith and Dr. Karen Patricia Williams. Location: 1240 Anthony Hall.

Dr. Wei Yan, MSU Itinerary Page 3 of 4

Tuesday, June 5, 2012, Continued

5:30 p.m. Dinner Dr. Asgerally Fazleabas and Dr. George Smith. University Club, 3434 Forrest Rd., 517-353-5111. Contact: Dr. Fazleabas 630-915-8054, Dr. Smith 517-881-0713.

CONTACT INFORMATION:

Dr. Wei Yan, M.D., Associate Professor – Department of Physiology and Cell Biology, University of Nevada School of Medicine Center for Molecular Medicine, Office 775-784-7765, wyan@medicine.nevada.edu

GRAND RAPIDS

Dr. Richard Leach, Professor and Chair - Department of Obstetrics, Gynecology & Reproductive Biology, , Michigan State University, Office 616-234-5157, Richard.Leach@hc.msu.edu

Dr. Asgerally Fazleabas, Director of Women’s Health; Associate Chair of Research, Department of Obstetrics, Gynecology & Reproductive Biology, RDSP Cluster Hire Search Committee Co-Chair, Michigan State University, Office 616-234-0981, asgi@hc.msu.edu

Dr. John Risinger, Director, Division of Reproductive Biology, Department of Obstetrics, Gynecology & Reproductive Biology, RDSP Cluster Hire Search Committee, Michigan State University, Office 616-234-0989, john.risinger@hc.msu.edu

Dr. JaeWook Jeong, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Office 616-234-0987, jaewook.jeong@hc.msu.edu

Dr. Sangeeta Devi Yendrembam (Y. Sangeeta Devi), Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Office 616-234-0988, sangeeta@hc.msu.edu

Dr. Ying Chen, Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Office 616-234-5793, ying.chen@hc.msu.edu

Dr. Kai Wang, Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Office 616-234-0986, kai.wang@hc.msu.edu Thuy Tran, Office Assistant, Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Office 616-234-0983, Thuy.Tran@hc.msu.edu

CONTACT INFORMATION: East Lansing

Dr. David Arnosti, Professor , Biochemistry and Molecular Biology, Michigan State University, Office 517-432-5504, arnosti@msu.edu Dr. John Baker, Professor and Associate Director, AgBioResearch, Michigan State University, Office 517-355-0123, baker@anr.msu.edu Dr. Jose Cibelli, Professor, Department of Animal Science and Physiology, RDSP Cluster Hire Search Committee, Michigan State University, Office 517-432-9206, cibelli@msu.edu Dr. Sue Conrad, Professor , Microbiology and Molecular Genetics, RDSP Cluster Hire Search Committee Michigan State University, Office 517-884-5326, conrad@msu.edu

Dr. James Ireland, Professor - Department of Animal Science, Michigan State University, Office 517-432-1354, ireland@msu.edu

Dr. Wei Yan, MSU Itinerary Page 4 of 4

Dr. Jason Knott, Assistant Professor, Department of Animal Science, RDSP Cluster Hire Search Committee, Michigan State University, Office 517-432-5446, knottj@msu.edu Dr. David Kreulen, Professor and Acting Chair, Department of Physiology, RDSP Cluster Hire Search Committee, Michigan State University, Office 517-881-8184, dkreulen@msu.edu

Dr. Sheba Mohankumar, Assistant Professor , Pharmacology & Toxicology, College of Veterinary Medicine, Michigan State University, Office 616-234-0989, mohankumrs@cvm.msu.edu

Dr. Richard Pursley, Professor , Department of Animal Science, Michigan State University, Office 517-432-6178, pursleyr@msu.edu

Dr. George Smith, Professor , Department of Animal Science and Physiology;, RDSP Cluster Hire Search Committee Co-Chair, Michigan State University, Office 517-432-5401, smithge7@msu.edu Dr. Janice Swanson, Professor and Chair, Animal Science Department, Michigan State University, Office 517-432-4134, swansoj@msu.edu Dr. Karen Patricia Williams, Associate Professor, Department of Obstetrics, Gynecology & Reproductive Biology, RDSP Search Committee, Michigan State University, Office 517-432-4790, karen.williams@hc.msu.edu

Seminar Series

WEI YAN, M.D. PH.D.

ASSOCIATE PROFESSOR UNIVERSITY OF NEVADA SCHOOL OF MEDICINE

JUNE 4, 2012

Regulation of Spermatogenesis: from Genetics to Epigenetics

1415 BIOMED PHYSICAL SCIENCE BUILDING EAST LANSING, MI

4:00 - 5:00 P.M.

Dr. Yan is a candidate for a senior faculty position as part of the Reproductive and Developmental Sciences Program Cluster Hire. His research interests are centered on how sperm and oocytes are produced in mammals. His laboratory investigates which of the germ cell-specific genes and pathways they are involved in are essential for successful production of gametes. Current research efforts in his laboratory are focused on the following three topics: (1) the regulation of protein turnover by ubiquitination during spermiogenesis; (2) the control of cytoplasm removal during sperm individualization and spermiation (sperm release); (3) physiological roles of germ cell-specific small non-coding RNAs. For more information regarding this seminar, please contact Jane Worthington at worthi26@msu.edu

MICHIGAN STATE UNIVERSITY

REPRODUCTIVE & DEVELOPMENTAL SCIENCES PROGRAM

Program Director/Principal Investigator (Last, First, Middle): Wilkinson, Miles

PHS 398/2590 (Rev. 11/07)

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME Wei Yan

POSITION TITLE Associate Professor of Physiology, Molecular and Cellular Biology eRA COMMONS USER NAME (credential, e.g., agency login)

weiyan EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY

China Medical University, Shenyang, China M.D. 1985-1990 Medicine/Forensic Medicine University of Turku, Turku, Finland Ph.D. 1996-2000 Reproductive Endocrinology Baylor College of Medicine, Houston, TX, USA Post-doc 2000-2003 Reproductive Biology

A. Personal Statement I worked as a coroner (forensic pathologist) after I graduated from medical school. I later worked on DNA-based individual identification techniques for forensic purposes. After 5 years as a forensic expert, I realized that I liked biomedical research. So I went to University of Turku, Finland and started working on testicular biology under the guidance of Drs. Jorma Toppari, Martti Parvinen and Ilpo Huhtaniemi. After I finished my PhD, I joined Dr. Martin Matzuk’s lab in Baylor College of Medicine, Houston, TX as a post-doc and worked on ovarian biology. I started my own lab in 2004 in the University of Nevada School of Medicine. My primary research interests lie in gametogenesis. In particular, I am curious about the molecular mechanism underlying sperm production and paternal contribution to fertilization and early embryonic development. My work has been continuously funded by the NIH for the past 8 years. I have published 72 papers as of March 2012. My other credentials can be found below. In general, I regard myself as a diligent, dedicated and passionate researcher with a positive attitude towards life, work, family and friends. B. Positions and Honors Position and employment Associate Professor (2009-present, tenured): Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV Laboratory Director (2004-present): Northern Nevada Fertility Clinics, Renown Medical Center, Reno, NV Assistant Professor (2004-2008, tenure-track): Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV Instructor (2003-2004): Department of Pathology, Baylor College of Medicine, Houston, TX. Professional Memberships Sigma Xi The Endocrine Society The American Society of Andrology The Society for the Study of Reproduction Grant Reviewer 2010-2015 Standing member, CMIR study section, NIH 2007-present Ad-hoc reviewer for NIH-CSR study sections and special emphasis panels, including ZHD1

DSR-Y study section, CMIR, DEV1, DEV2, etc.. 2007-Present Ad-hoc reviewer for foreign funding bodies, including the Czech Science Foundation, the

Welcome Trust Foundation, UK, Chinese National Science Foundation, and the Research Council for Earth and Life Science (ALW), Netherland Organization for Scientific Research (NOW).

Program Director/Principal Investigator (Last, First, Middle): Wilkinson, Miles

PHS 398/2590 (Rev. 11/07) Biographical Sketch Format Page

Honors 2012: The American Society of Andrology Young Andrologists Award. 2009: The Society for the Study of Reproduction Young Investigator Award. 2009: The Nevada High Education System Regents’ Rising Researcher Award. 2003: Finalist for the American Society of Andrology Trainee Award, Phoenix, Arizona. 2002: Ernst Schering Foundation Young Scientist Fellowship. 2000: Finalist for the NAFA Young Scientist Award, Malmö, Sweden.

B. Selected peer-reviewed publications (out of 72 total as of April 2, 2012, in chronological order). Most relevant to the current application: 1. Ro S, Park C, Song R, Nguyen D, Jin J, Sanders KM, McCarrey JR, Yan W (2007) Cloning and expression

profiling of testis-expressed piRNA-like RNAs. RNA 13:1693-1702 2. Ro S, Park C, Young D, Sanders KM, Yan W (2007) Tissue-dependent paired expression of miRNAs.

Nucleic Acids Research 35:5944-5953 3. Ro S, Park C, Young D, Sanders KM, McCarrey JR, Yan W (2007) Cloning and expression profiling of

testis-expressed microRNAs Developmental Biology 311: 592-602 4. Ro S, Song R, Park C, Zheng H, Sanders KM, Yan W (2007) Cloning and expression profiling of small

RNAs expressed in the mouse ovary. RNA 13:2366-2380 5. Yan W*, Morozumi K, Zhang J, Ro S, Park C, Yanagimachi R (2008) Birth of mice after intracytoplasmic

injection of single purified sperm nuclei and detection of messenger RNAs and microRNAs in the sperm nuclei. Biology of Reproduction 78:896-902 (*corresponding author)

6. Papaioannou MD, Pitetti JL, Ro S, Park C, Aubry F, Schaad O, Vejnar CE, Descombes P, Zdobnov EM, McManus MT, Guillou F, Harfe BD, Yan W, Jégou B, Nef S (2009) Sertoli cell Dicer is essential for spermatogenesis in mice. Developmental Biology 326:250-259

7. Song R, Michaels JD, Ro S, McCarrey JR, Yan W (2009) X-linked microRNAs escape meiotic sex chromosome inactivation. Nature Genetics 41:488-493

8. Ro S, Yan W (2010) Detection and quantitative analysis of small RNAs by PCR. Methods in Molecular Biology 629:295-305.

9. Ro S, Yan W (200) Small RNA cloning. Methods in Molecular Biology 629:273-85. 10. Song R, Ro S, Yan W (2010) In situ hybridization detection of microRNAs. Methods in Molecular Biology

629:287-94. 11. Park C, Yan W, Ward SM, Hwang SJ, Wu Q, Hatton W, Park J, Sanders KM, Ro S (2011) MicroRNAs

dynamically remodel gastrointestinal smooth muscle cells. PLoS ONE 6(4): e18628. doi:10.1371/journal.pone.0018628

12. Park C, Hennig GW, Sanders KM, Cho JH, Hatton WJ, Redelman D, Park JK, Ward SM, Miano JM, Yan W, Ro S (2011) SRF-dependent microRNAs regulate gastrointestinal smooth muscle cell phenotypes, Gastroenterology doi: 10.1053/j.gastro.2011.03.058.

13. Song R, Hennig G, Wu Q, Jose C, Zheng H, Yan W (2011) Male germ cells express abundant endogenous siRNAs. Proceedings of the National Academy of Sciences USA. 108:13159-64.

Other relevant publications: 1. Yan W, Assadi AH, Wynshaw-Boris A, Eichele G, Matzuk MM, Clark GD (2003) A novel role for platelet-

activating factor acetylhydrolase 1b in mouse spermatogenesis. Proceedings of the National Academy of Sciences USA 100:7189-7194.

2. Yan W, Huang JX, Lax AS, Pelliniemi L, Salminen E, Poutanen M, Toppari J (2003) Overexpression of Bcl-w in the testis disrupts spermatogenesis: revelation of a role of BCL-W in male germ cell cycle control. Molecular Endocrinology 17:1868-1879.

3. Yan W, Ma L, Burns KH, Matzuk MM (2003) Identification of a novel spermatid-specific linker histone H1 involved in chromatin remodeling during mammalian spermiogenesis. Proceedings of the National Academy of Sciences USA 100:10546-10551.

Program Director/Principal Investigator (Last, First, Middle): Wilkinson, Miles

PHS 398/2590 (Rev. 11/07) Biographical Sketch Format Page

4. Yan W, Ma L, Matzuk MM (2004) Haploinsufficiency of KLHL10 causes male infertility. Proceedings of the National Academy of Sciences USA 101:7793-7798.

5. Yan W, Ma L, Stein P, Pangas SA, Burns KH, Bai, YC, Schultz, RM,, Matzuk, MM (2005) Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Molecular and Cellular Biology 25:4615-4624.

6. Jin JL, O’Doherty AM, Wang SH, Zheng HL, Sanders KM, Yan W (2005) Catsper3 and Catsper4 encode two cation channel-like proteins exclusively expressed in the testis. Biology of Reproduction 73:1235-1242

7. Wang SH, Zheng HL, Esaki Y, Kelly F, Yan W (2006) Cullin3 is a KLHL10-interacting protein preferentially expressed during late spermiogenesis. Biology of Reproduction 74:102-108

8. Greenbaum MP, Yan W*, Wu MH, Lin YN, Agno JE, Sharma M, Braun RE, Rajkovic A, Matzuk MM. (2006) TEX14 is essential for intercellular bridges and fertility in male mice. Proceedings of the National Academy of Sciences USA 103:4982-7. (*co-first authors)

9. Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM (2006) Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. Human Molecular Genetics 15:3411-3419.

10. Zheng H, Stratton CJ, Morozumi K, Jin J, Yanagimachi R, Yan W (2007) Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation and male infertility. Proceedings of the National Academy of Sciences USA 104:6852-6857

11. Jin J, Jin N, Zheng H, Ro S, Tafolla D, Sanders KM, Yan W (2007) Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility. Biology of Reproduction 77:37-44

12. Lin YN, Roy A, Yan W, Burns KH, Matzuk MM (2007) Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Molecular and Cellular Biology 27:6794-6805

13. Ma L, Buchold GM, Greenbaum MP, Roy A, Burns KH, Zhu H, Han DY, Harris RA, Coarfa C, GunaratnePH , Yan W, Matzuk MM (2009) GASZ is Essential for Male Meiosis and Suppression of Retrotransposon Synthesis in the Male Germline. PLoS Genetics 5(9): e1000635. Published online 2009 September 4. doi: 10.1371/journal.pgen.1000635.

14. Yan W, Slaymaker S, Si Y, Jin J, Zheng H, Aslanian A, Saunders L, Verdin E, Charo IF (2010) Zmynd15 encodes a transcription repressor essential for late spermiogenesis and male fertility. Journal of Biological Chemistry 285:31418-31426.

15. Bao J, Zhang J, Zheng H, Yan W (2010) Ubiquilin1is localized to the junction of Sertoli cell and developing spermatids. Molecular and Cellular Endocrinology 327:89-97.

16. Bao J, Zhang J, Song R, Zheng H, Yan W (2011) Ran-binding protein 17 is preferentially expressed in the testis and is associated with the XY body and manchette during spermatogenesis. Molecular and Cellular Endocrinology 333:134-142.

C. Research Support Ongoing Research Support “Regulation of Spermatogenesis by X-linked miRNAs” PI: Wei Yan, NICHD, RO1 HD060858, 2010-2015 Major Goal: Mechanism of miRNA-mediated meiotic sex chromosome inactivation in mice. “Smooth muscle plasticity: COBRE” PI: Kenton Sanders, NIH/NCRR, P20-RR18751, 2009-2014 I serve as the Director of the Molecular and Transgenic Core (Core B) and a mentor of Project 4. Major Goal: Investigate the role of plasticity in smooth muscle.

Program Director/Principal Investigator (Last, First, Middle): Wilkinson, Miles

PHS 398/2590 (Rev. 11/07) Biographical Sketch Format Page

Completed Research Support “Regulation of Spermiogenesis by KLHL10” PI: Wei Yan, NICHD, RO1-HD050281, 2006-2011 Major Goal: Study the molecular mechanisms by which KLHL10 regulate spermiogenesis. “Small RNA profiling during spermatogenesis” PI: Wei Yan, NICHD, RO3-HD048855, 2004-2006 Major goal: Cloning and preliminary characterization of small RNAs expressed in the testis during development and spermatogenesis. Role: PI “Exploring Molecular and Cellular Approaches to Rejuvenate the Aging Testis” PI: Wei Yan, Sanford Center for Aging, 2006-2008 Major goal: To study the molecular basis of testosterone-secreting Leydig cell aging and the feasibility of Leydig cell transplantation in Rats.

WEBINAR

International Symposium on Beef Cattle Welfare

June 6th 10:30 - 6:30 EST June 7th 10:30 - 2:30 EST

162 Food Safety and Toxicology - MSU http://www.beefwelfare2012.ca

This live webinar is by the sponsored MSU CVM Food Systems Fellowship Program (cvm.msu.edu/fsf). You are welcome to attend all or parts of the webinar. You can view the entire program at www.beefwelfare2012.ca. There is no charge. The webinar will be in 162 Food Safety and Toxicology (http://maps.msu.edu/interactive/). For more information, please contact Dan Grooms groomsd@cvm.msu.edu.