Figure S1 Flowchart for bioinformatics analysis of datasets from TCGA, GTEx and GEO.

Figure S2 Heat map analysis of differentially expressed lncRNAs (A), miRNAs (B), and genes (C). The horizontal axis denoted the cluster analysis of each sample. The longitudinal axis indicated the cluster analysis of lncRNA, miRNA, or gene. High- or low-relative expression is displayed as a red or blue strip, respectively.

Figure S3 Results from the principal component analysis for integrated microarray studies downloaded from the GEO dataset. Two-dimensional plots of normal and tumor groups with the top two principal components. Horizontal and vertical axes represent the distribution of each sample within PCA1 and PCA2 respectively. PCA1: principle component 1; PCA2: principal component 2.

Figure S4 Survival analysis of miRNAs and mRNAs in ceRNA network.

Kaplan–Meier analysis of differentially expressed miRNAs(A), and mRNAs(B) in ceRNA network by comparing the higher(red) and lower(green) expressions with overall survival outcomes for patients with HGSOC. P-value set for this analysis is less than 0.05.

The bottom part shows the threshold set by R package. Horizontal axis: the expression level of a certain gene, Vertical axis: standardized Log-Rank statistic. Dotted line: the cutoff value for gene expression.

Figure S5 Correlation of lncRNAs, LINC00858 (A), FTX (B), and LINC00665 (C), expression with infiltrating levels of tumor purity (first column) and lymphocyte infiltration level in high-grade serous ovarian cancer.

Table S5 KEGG pathway enrichment for differentially expressed genes

ID

Description

P value

Count

Regulation

hsa04110

Cell cycle

8.01E-05

35

upregulation

hsa03030

DNA replication

0.00181

12

upregulation

hsa03010

Ribosome

0.002645

15

upregulation

hsa01230

Biosynthesis of amino acids

0.015409

14

upregulation

hsa00190

Oxidative phosphorylation

0.023202

13

upregulation

hsa03440

Homologous recombination

0.026669

10

upregulation

hsa04060

Cytokine-cytokine receptor interaction

0.034683

29

upregulation

hsa04218

Cellular senescence

0.035041

27

upregulation

hsa04657

IL-17 signaling pathway

0.049274

11

upregulation

hsa04022

cGMP-PKG signaling pathway

5.29E-05

17

downregulation

hsa04610

Complement and coagulation cascades

0.000681

12

downregulation

hsa04072

Phospholipase D signaling pathway

0.014802

16

downregulation

hsa04350

TGF-beta signaling pathway

0.021213

11

downregulation

hsa04140

Autophagy - animal

0.023443

13

downregulation

hsa04014

Ras signaling pathway

0.032845

21

downregulation

hsa04371

Apelin signaling pathway

0.038948

14

downregulation

hsa04630

JAK-STAT signaling pathway

0.038948

14

downregulation

Table S6 GO biological process for differentially expressed genes

ID

Description

Count

P value

Regulation

GO:0048285

organelle fission

93

5.12E-15

upregulation

GO:0007059

chromosome segregation

91

9.76E-21

upregulation

GO:0000280

nuclear division

90

2.27E-16

upregulation

GO:0098813

nuclear chromosome segregation

81

1.26E-19

upregulation

GO:0071103

DNA conformation change

73

2.27E-16

upregulation

GO:0000819

sister chromatid segregation

70

1.26E-19

upregulation

GO:0140014

mitotic nuclear division

68

1.51E-15

upregulation

GO:1901987

regulation of cell cycle phase transition

62

0.000873164

upregulation

GO:0006260

DNA replication

59

6.85E-09

upregulation

GO:0006323

DNA packaging

56

5.99E-14

upregulation

GO:0045787

positive regulation of cell cycle

56

0.000233921

upregulation

GO:0051052

regulation of DNA metabolic process

56

0.000976283

upregulation

GO:1901990

regulation of mitotic cell cycle phase transition

55

0.005152821

upregulation

GO:0048568

embryonic organ development

55

0.008049245

upregulation

GO:0009314

response to radiation

54

0.025804851

upregulation

GO:1901653

cellular response to peptide

38

0.029874989

downregulation

GO:0019216

regulation of lipid metabolic process

38

0.042661545

downregulation

GO:0007178

transmembrane receptor protein serine/threonine kinase signaling pathway

36

0.042661545

downregulation

GO:0071375

cellular response to peptide hormone stimulus

34

0.042661545

downregulation

GO:0071383

cellular response to steroid hormone stimulus

33

0.01133506

downregulation

GO:0061448

connective tissue development

29

0.029528939

downregulation

GO:0009755

hormone-mediated signaling pathway

27

0.047752345

downregulation

GO:0043401

steroid hormone mediated signaling pathway

26

0.014684241

downregulation

GO:0010517

regulation of phospholipase activity

11

0.049805782

downregulation

GO:0097035

regulation of membrane lipid distribution

9

0.044563787

downregulation

GO:0030318

melanocyte differentiation

8

0.014684241

downregulation

GO:0045332

phospholipid translocation

8

0.014684241

downregulation

GO:0034204

lipid translocation

8

0.016669149

downregulation

GO:0048070

regulation of developmental pigmentation

6

0.042661545

downregulation

GO:0032429

regulation of phospholipase A2 activity

5

0.035988155

downregulation

Table S7 OS-associated differentially expressed genes

Gene type

Regulation

Gene name

DEG

UP

CLDN6HTR3AFOLR1CLDN16SLC34A2MMP7SCGB2A1SOX11CRABP1CAPN13DPEP3C6orf223VTCN1PHOX2ACDKN2ACXCL17XAGE2PTH2RNXPH4KLK5FAM181ASMPDL3BILDR1AOC1SMIM22TMPRSS3KRT7LIN28BAQP5EPCAMPRSS21CLDN9GJB1LCN2ROS1GPR12LAMP3HIST1H3BFOXA2NOTUMSCGB1D2TMPRSS4GLYATL2FOXJ1HOXB8CACNG4CD24FOXQ1XDHGLDCKRT23MAL2SSTAP1M2PBKMMP1PADI3ETV4PKHD1C1orf210GMNCCDC20GPR39IGFL1PRSS8E2F8ESRP1LRRC55CYP24A1UCP2INAVACRABP2KCNS1FABP6LYPD6BSPDEFKDF1RAB25NEK2TACSTD2EHFELF3GRHL2PDE6GPCLAFC1orf116CEP55SYCE3HIST1H3CLGSNCKAP2LNEIL3BIRC5SKA3TTKEPHX4DGKKBIKSP8GPR19ST14MISPCCNA1RDM1CPMELKC2orf54MYH14PPP1R14DGJA8EDN2SLC35D3PRSS22KLHL14FAM83HBSPRYACY3AQP6METTL7BRRM2PKP3LAD1CYP2F1HMGA1C6orf132RIPK4CCL20MAJINNECTIN4FRMPD1RASAL1SAPCD2UGT8CCL25APELASERINC2LGALS14ADAMDEC1CDH18ASF1BFOXN1KLHDC7BSHISA9MACC1CDH6GAL3ST3SGO1FAM83EHES2DIRAS2POU2F3SPP1SLAMF9TK1GJB3FAM111BCLDN19C15orf48CDH12DCDC2KIF4ASPINT1E2F2OASLTFAP2ACHST6VPREB3GSDMCLRRC15TMC4ZIC3HIST1H2AJBCL2L14PYYUBE2TGABRPS100A14CRB3CCNE1LRRC8EHOXD1HRKSCNN1ATFAP2CDYDC2NCAPHRIPPLY3PPP1R14CSKAP1S100A2CYP1A2TGM7DLX4NPWKRT86NRTNCLSPNSLCO6A1OVOL1ATP10BESCO2CCL7SLC4A11IFNL1ESPNSMKR1DTLFUT3CCNB2FOXE3HOXB4VSTM2LCDC45TMPRSS13GALPNLRP7GRHL3ECT2ASRGL1CRTAC1EXO1ERFEIFI27PLS1COMPASCL2CELSR1HMGA2KIF18APRRG2HAPLN1EVA1AERBB3DNAAF3TTC39AASPMLMX1BIL4I1DRC1SLITRK1HIST1H2ALCKS2PKMYT1SPXLPAR3KIF1ACDCA5BICDL2NEURL3DAND5HIST1H2BHCDK1ESPL1PRR7CENPAATP1A3CENPFRUNX3PADI2CACNA1BTPD52CDKN3VAV3ISG15BFSP2SUCNR1TBX20ARL4CCENPMOAS2P2RY6NDC80CLDN10HIST1H2ABRAD51AP1CCR3CELSR2CYP4F11PQLC2LPAQR4CCL17ZNF560C2orf88GABRQCAMK2N2TTC22MIOXCHRNA9LEMD1BLMROPN1LTMEM61HSH2DKPNA2POLQFAT2MECOMSBK1F12CHODLLMX1AELF5SERPINB10RSPH6AELOVL3SPTBN2LMO1TLCD1HIST1H2BBTMEM45BST6GALNAC2NUP210VNN3ARHGAP11AKCNK15NOGPROM2CCNB1CDCA7PRAMEZWINTRPL39LPLAC1DLEU7GALNT6CCDC187SRD5A3CHRNA6POC1APHOSPHO1CA2HS3ST4CXCL13TRIP13RSPO4MAD2L1PLK1L1CAMMEOX1SPON1RCAN3MAPK15PCP2LAPTM4BADTRPMFAP5SH2D4BABHD11HMGB3SLAMF7SLC27A2HIST1H3ABAIAP2L1RAB39BPRKCGCENPKKCNN4SLC2A1OR1Q1CD3GIGFBPL1KCNJ16UNC93B1CSMD2MPZL2FGF8TNFRSF12AONECUT3CCDC167THEM6CCND1FAM155BKAZALD1TACC3SYNE4XPR1DLGAP3USP18KRTCAP3SULT1C2ACRV1HUNKIL32PMCHALPK2GRHL1C3orf80P2RY2PITX3BTLAAPOA1C1orf87SEMA3FFGF23LARGE2CXCR4VWDESHCBP1TEKT2ESM1TNFAIP6SEMA5BRHPN1CKS1BITGB8BARX1TRPV4KCNQ3NCEH1GALNT3MZB1OCIAD2ZBTB42ZDHHC12IL21RDLL3MARVELD3RAB11FIP4SYTL1ABCA4SLC6A12MREGTRIB1DHCR24IDH2MUC4NDUFB9JPT1NKAIN1SHISA8BACE2HPDLCATSPER1PPP1R14BPRR18VANGL1C2orf15GNG13EXOSC4ANKFN1FAM178BGPT2CLEC5AMPP7EXPH5LACTB2TDRKHLRRC8DCD207MPZL3C9orf16PSENENORC6KLK4TLR10ORC1IL27RAANKRD45INHBBALG3ST6GALNAC5CXorf58RYR1DSC1PYCR1UBALD2NOX4WDR62TRIM59PCDH7SORT1HIST1H2BCAK7NCAPD2LYPLA1E2F3ALDH3A1GRIN2DRMI2MYCNFCGR1AMYEF2GINS2DRD2NME1CHAC2PCDH19HTR1DERCC6LBEND3RNASEH2AENKURSMC4C3orf67PAFAH1B3KIAA1549LCDK5PITPNM1ULBP1CLEC1BPROSER2SLC25A10PNPMS4A8C2orf50TESMRPL47MRPL14MAP4K1TRPM1SLC39A4GINS4COL13A1SPC24MRPL13SLC7A1JUPKCTD1USH1CGPR84GIPC1GAPDHMRPL3STOX1SYNGR2PCNALSM4DPP3AHNAK2RAB3DAPLNREPOPIL12AFUT8SYNGR3C20orf204MRPL15RTKNBAK1STRBPRGCCFAM171A2SLC50A1SLC39A11SOWAHAMCUR1MRPS12ATP6V0E2MAP7D2NRARPGDF9PIF1PTX3UPK2JPH1FEN1TSTA3PLA2G4FCRIP2PRC1DARS2TMEM19TRPM2SIX4PLD4E2F1H2AFXZNF165SORDCCDC58HDGFS100A13RAB26CRACR2BLRG1FAM166BCHRNA5PRKXTATDN1CENPLRBM38ULBP3TEAD4MEX3ASDHAF3CAPN12FMN1TONSLATF5PRELID1TPMTRASGEF1CUNC5BDSCC1AGBL5COA6LIN28APARS2C5orf22SLC38A1NETO2TRIB3NDC1PSMB2FBP2SLA2CFAP74CACNA1APYCR3ZNF93CHEK1HIST3H2ATECPLEKHF2TIMM17BCCDC160ZFP57MUC20MRPL12FZD2DPY30PPP4CMSH2CTLA4MTHFD2CCNA2FSD1ATP6V1FSNX31NDUFB11SLC38A4TMEM223NAA38SLC52A2CENPHMAP2K6LRGUKNUDT14PRKCDEXOSC5DYRK2RHNO1SUSD2TYMSCCDC34CACNG8SLC2A12ETV6TBCCMOCS3TIMM23MRPS15ATOH7CCR4DHFRCYC1DNMT3BCABP4YEATS4LRRIQ3RCN2RCC2SFMBT1PUF60CCDC169COPEPCDHA2TBC1D31PFKPENO1MGME1TNFRSF10AFAM81ADERL3ROMO1TPI1CHCHD3APBA2HMBSLLGL2KCNS3CLPBANKEF1PGAM5EPHA1FILIP1MFSD3FLAD1TBC1D7CCNB3MRPS18ATRIM47GMIPPNMA3PDE9ACBX2ZCRB1PRIM2RNF5NCAPG2SUV39H2CSE1LLSM2BTG3C5orf34KIF20BFIBPCDK2AP2HNRNPABGPR27FAM107APNCKPTGESBATF2ST3GAL6EME1METTL27RTN3GPSM3FNDC11PTRH1EIF6RRAGDSRGAP3C19orf53NUDT19YRDCSHMT2NOCTPDIA4BRIP1ZNHIT1RUVBL1SPAG5GEMIN7AP1S1POP7DNAAF2LRRC8BDCLRE1BEBPRELBATP2C2TMC7CEBPGCCDC177CD6CCT5NDUFA9CYCSAGPAT2ENO3SNRPCDNPH1HELZ2LRRC43KIF22NDUFA4L2ZSCAN16SLC25A33SIGLEC5SAMD1SAC3D1DCAF13BDH1RAD54BHAUS8TRMT12SLC22A18ASC5orf30YARS2C1orf74HSPE1ADGRE2VRK1PAK4PFDN4FKBPLUQCC3EEF1E1SLC2A6VIPR1ACTR3CDDX39AOCA2FARSACAPN1RPP40IL23ATMEM38AERI3B4GALT5ZFATCDK16EDN1NUDT1RFC4TUBG1ACTL6APAQR5NUDT15SRPK1RGS16C1orf127ZNF365KLK12TCF19PAK1IP1PRIMA1RFXANKSNX32GADD45GIP1TFPTIPO4ADAM8TOMM40HEY2LRIG1ZDHHC9ZDHHC20HAPLN3NIPSNAP1DNA2AP1S2KRASZNF440CLCF1TRIAP1YDJCMRPS30ZDHHC23ARPC5LBRIX1WDR77CENPIFAM189BMROH1TMEM267HM13NDUFAF4HPRT1GGCTIER5LMAPK13RITA1GMPSIQCDMAGOHBPGPLPAR2MRPL52MRPS16MRPL36GSTP1RRP36TBC1D24ERGIC2GFOD1VPS37DTIMM50RUVBL2CNNM4TTYH3RFC2MTX2ITGAXZNF239TOMM34ANAPC15IL1RL2COMMD7RAVER1POLE2DHRS11MLF2TMEM54EFCAB11PRCCATAD2ADASUV39H1MRPS34NEU1MDKTNFRSF4ZNF92TPM4MCM6THAP10RAD23AZNF787MRPL33ACOT7KLRG1FAM32ATDP1CLPTM1LNR2C2APBABAM1ALAS1ADRA2CGMNNDHRS13FANCD2PAIP1C19orf54INTS5RPP38STMN1MXD3TOPBP1MYO6ABT1SLC25A39YES1PPM1GPUS7BORAKLHDC9ESRRAPPP1R16AKEAP1TMEM63CGLDNLYPLA2SMARCC1EHD3SPDL1UBE2V2GATAD2AATP23SLCO5A1POLR2DARHGEF2APEX2CCT3WDR3TARBP2RHEBL1B3GALT6ATG101CHAF1AZNF593TLNRD1SLC7A5NOL10S100A3CDC7REEP4

DOWN

TXNIPRWDD4MACF1COBLL1PDZD2HMBOX1GKAP1EMP3PLXNA4IKBKBNFAT5ZBED5MBD1PIGHSEC63KCTD9MXI1RBL2FAM160B1THUMPD2ZNF655STOMRIC1ZNF81EID3KIF16BFAM160A2DDX3XDYNC1LI2RPL3TBC1D8BZKSCAN7TMEM176BRHOBTB1RCBTB2TCEAL9ZNF711PRKAB2STAT6TMEM43ZCCHC14TBRG1SFRP4USPL1KIDINS220ZNF641ENTPD4NCBP3ZCCHC12MST1DDHD2CCNT2MAP3K3NPDC1PCDH9FAM126AZBTB4UBE2G2CDK20TXLNGPI4KAHNRNPH3GGNBP2PCDH18TMEM50BPRRX1ZC3H6CASD1TLE2MARVELD1KIFC3PHLPP2SNAI2DOCK1TNFRSF10BCCDC84COG3POGZPRPF3GNA11PLSCR4GNG2AHNAKMADDEIF3LERCC6L2TEP1OPHN1KIAA1958CREBRFANTXR1GSE1RNF146UHRF2ZNF407MAMDC4RASA1RAB30NMNAT3ERCC5AKAP9DDX5RNF128ENOSF1ZCCHC11MTMR10FOXP1GNA12LYSMD4ZNF532NMRK1MTFR1LSCD5ZC3H12CSLC26A11THOC1B4GAT1LATS2RPS6KA2MORC3CENPVCWC25THBDFRYSETD7ARRDC3SLC26A6METTL7AZNF234ST13ZNF266FERMT2CBX6FLNCLATCOLGALT2AGAP4GATAD1GNAZSERGEFHECAVPS13BHNRNPA1KATNAL1MLXIPSLKMSANTD2BBS7CDIP1AKAP13LIMA1JOSD1BTN2A1NXF1ZNF493RIPOR1CYP4V2PPWD1ANKRA2ARHGAP19ASB1ABRSLC7A8DOCK4PIM1MON2SCN1BIL6STZRSR2MORC4RAB31STK11TRIM4PCDHB16CPB1PDLIM3ATP9BCTSFSLFN11ATG2BADPRMEXOC6BZNF559ZNF70CYBRD1ZFYVE16MZF1CPNE8ZNF275OCRLKLHL36TNRC6AAP1G2UBXN6MAP3K4NEK3PDE8AZBTB40PLBD2FRMD6ATP6V0A1H6PDKAT2BHSPB8COLCA2ZZEF1CLDN15DENND4AMAP4K5CGNL1CLCN5ARHGEF7MTMR3TMEM98KIZSMC5SNX33PDGFRLADCY9RORBTRIM23HSPA12ACDADC1MTX3PALMNEFHNEK1PLS3DCUN1D4FYCO1HNMTHCFC2UFSP2AHI1GGT5DDHD1CHST15CEP120CIDEBPOLDIP3ADAMTS3SETDB2C5orf56RAB8BDOCK5RBPMS2ZSWIM8NACC2FGFR1OP2PIK3R1BCO2HSPB3GBGT1TTC8GNECRACR2AEPB41L2MLLT6CCDC93XPCEPHX2DGKHC1RLDIRAS1MDN1RALGAPA1OLFML3SHPRHPCNX1LSAMPMPHOSPH8EHD2TK2HERC1MYSM1MTHFRMGEA5RBFOX2DIP2CFAM13AABCD4EID2BSPARTSMG6WDR59ZNF224MTURNLONRF1EVC2TPM1C20orf194NDEL1PCGF3MMP16ERO1BCORO2BEOGTLIFRING2KLHL13DOPEY1MRC2DOK6THRADENND3ABLIM1BRD1SLC22A17CCNL1TMEM8BATP8B4PALLDZEB1G0S2SLC9A9MEF2CCLIC2FNBP4TARSL2PCED1BRXRAIGIPTSPAN4TNS1RNASELERMARDICA1LTSC1DEF8HYICLMPYTHDC2CITED2ETS2P2RX7STMN3N4BP2L2BMP2PAQR7ADRA2ADNAJC12ZBTB20POLIHTRA1MTERF2ANGPTL2ZNF594TACC1TGFB1I1ST3GAL5DMTF1CALD1LIX1LDTX3PRKAR2BTTBK2CAV1MICAMTERF4ABTB1CYP27A1NICN1C5PMM1SSC5DUSTSH3PXD2AOGTID3JAK2GULP1PRKD1DCHS1KCNJ8GCNT7MICAL1ARHGAP21TMEM91OTUD3DMDDSCAML1C11orf95RHOBTB2FHL1SCARB1SLC16A4PAXBP1CLEC2BTOM1L2PMP22LRCH2SYCP2LPRICKLE2PTGISCLIP4CPQBICC1EPB41L3ARHGEF6NEK9METAP1DSMARCA2ANXA6FBN1ACCSRUNDC3BGARNL3SPAG9NAP1L5CREBZFLYRM9TEFIRS1CAB39LARMCX1TPM2ABLIM3SLC16A7RBP1CAVIN1NR3C2GLULSTX2SECISBP2LRP1CAPRIN2AKR1C2INTUARHGEF26ZHX3INTS6LFEZ1FAM13CMITFWNT2BNAP1L3SH3BP5TMOD2EPS8PRKG1PAN2AMIGO2MAPKBP1CDH11SUN2HEPHZCCHC24ARNTLOLFML1CTNNAL1KIAA1109PKD2SOBPC8orf88C9orf72NDNMTUS1CRY2WHRNABCG2PTPN13SNAP91SLC23A2CHST3RIC3SNCASMPD3NINLBTAF1GFRA1GABBR1VIMAGAP9GALNT10ASH2LC3orf70ATP8B2P2RY1TNNI3KPAPSS2PHF1VGLL3HOXC6SERP2KLHDC8BPLCL2SLC26A4TCEAL3TMEM200ATROSLC25A37MAFLHFPL6DYNC1I1DAPK1RAPGEF4CLK1TRABD2ARBM6FGF2TIMP2EDNRATFPIST3GAL4SESN1WFS1TAF1CNFIL3RGNCASP9KLHDC1KANK2PEX5LMYOM2ABCA5WSB1MICU3DCLK1LYVE1SMAD9SULF2TTYH2AKAP17AFAT4ZEB2OMDRUFY3TBC1D2BNUDT11FAM198BRGS2EZH1SOCS2MRVI1RBPMSC1SAKR1C1RBMS3COX7A1PDZRN3PBX3GSTM3NBL1TSC22D3ENOX1EMILIN1NPHP3TWIST2CFHGATMAKAP12TNS2ADHFE1CNRIP1DCNKLF4PPP1R12BGFPT2PARM1RPRMSMOC2DSTPDE2ACOL14A1VLDLRCPEB1PLA2R1PON3PRSS35JAM3PSD3B3GALT2CBX7TCEAL4ANTXR2ADGRB3MRGPRFTBC1D4LIN7AKLF9CAPN3CAVIN2RHOBTB3ATP8A1LRRC17ARHGAP10TGFBR3BAHCC1WNK4ZDBF2SLC7A2ADH1CCSGALNACT1PHACTR3BMPERITPR1KCNT2IGFBP4HS6ST2CLDN11MTUS2PDE7BKLF2TSHZ3MAOAOGNSNCAIPPID1PABPC5ZMAT1YPEL4TBX3ZNF331UBE2Q2LANKRD29ROBO3SLC25A27MAP3K5GPAT3GOLGA8NRAB9BDPTTCF21PEAR1ADGRD1F3DESCOL16A1MCCRASL11BPDK4ADAM33SYNE1PDGFRAAMHR2PODNNDNFSTARD9ZNF385BSLC4A3C21orf62CXorf57ADH1BKLHDC8AHAS1MAMDC2INHANRKCMYA5TDRD10PLA2G2AC7HLFSIGLEC11PEG3ABCA6ABCA8GSTM5MUM1L1SCN7ASTARC4BPBWFIKKN2

DEL

UP

LINC01297LINC01224PART1LINC01667LINC00284OVAALLINC00592LINC00858LINC01215LINC01532LINC01607LINC00221LINC00668LINC00052LINC00536HAGLRLINC01136LINC00867LINC00665LINC01558DLEU1 SAMMSON LINC00996PCAT6LINC00240

DOWN

FTXLINC00622MGC16275C5orf56LINC00173GAS1RRLINC00887 LINC00893

DEM

UP

hsa-let-7b-5phsa-miR-16-5phsa-miR-23a-3phsa-let-7f-5phsa-miR-24-3phsa-miR-27a-3phsa-miR-29c-3phsa-let-7g-5phsa-let-7i-5phsa-miR-130a-3phsa-miR-27b-3phsa-miR-15b-5phsa-miR-106b-5phsa-miR-26b-5phsa-miR-20ahsa-miR-23b-3phsa-miR-148a-3phsa-miR-15a-5phsa-miR-200c-3phsa-miR-10b-5phsa-miR-25-3phsa-miR-34a-5phsa-miR-30d-5phsa-miR-223-3phsa-miR-1225-5phsa-miR-342-3phsa-miR-93-5phsa-miR-494-3phsa-miR-30c-5phsa-miR-331-3phsa-miR-100-5phsa-miR-320a-3phsa-miR-324-3phsa-miR-20b-5phsa-miR-497-5phsa-miR-193a-3phsa-miR-199a-5phsa-miR-374ahsa-miR-125b-5phsa-miR-221-3phsa-miR-98-5phsa-miR-574-3phsa-miR-126-3phsa-miR-376chsa-miR-188-5phsa-miR-148b-3phsa-miR-136-5phsa-miR-660-5phsa-miR-886-3phsa-miR-155-5phsa-miR-424-5phsa-miR-222-3phsa-miR-381-3phsa-miR-150-5phsa-miR-127-3phsa-miR-132-3phsa-miR-542-3phsa-miR-340-3phsa-miR-340-5phsa-miR-532-5phsa-miR-486-5phsa-miR-202-3phsa-miR-874-3phsa-miR-532-3phsa-miR-362-5phsa-miR-654-3phsa-miR-769-5phsa-miR-505-3phsa-miR-487b-3phsa-miR-557hsa-miR-409-3phsa-miR-212-3phsa-miR-337-5phsa-miR-1228-3phsa-miR-194-5phsa-miR-423-5p

DOWN

hsa-miR-324-5phsa-miR-551b-5phsa-miR-194-3phsa-miR-150-3phsa-miR-106a-3phsa-miR-24-2-5phsa-miR-18ahsa-miR-20b-3phsa-miR-449b-5phsa-miR-661hsa-miR-200a-5phsa-miR-558hsa-miR-132-5phsa-miR-338-5phsa-miR-374a-3phsa-miR-193a-5phsa-miR-185-3phsa-miR-769-3phsa-miR-367-3phsa-miR-15b-3phsa-miR-136-3phsa-miR-214-5phsa-miR-127-5phsa-miR-222-5phsa-miR-886-5phsa-miR-223-5phsa-miR-10b-3phsa-miR-331-5phsa-miR-576-3phsa-miR-25-5phsa-miR-376a-5phsa-miR-16-1-3phsa-miR-200b-5phsa-miR-802hsa-miR-148a-5phsa-miR-342-5phsa-miR-106b-3phsa-miR-34a-3phsa-let-7g-3phsa-miR-101-5phsa-miR-29b-1-5phsa-miR-195-3phsa-let-7f-1-3phsa-miR-92a-1-5phsa-miR-23a-5phsa-miR-200c-5phsa-miR-497-3phsa-miR-27a-5phsa-miR-130a-5phsa-miR-424-3phsa-miR-23b-5phsa-miR-30d-3phsa-miR-27b-5phsa-miR-100-3phsa-miR-145-3phsa-miR-141-5phsa-miR-125b-1-3phsa-let-7b-3p

Table S8 KEGG pathways for genes in ceRNA network

ID

Description

P value

Gene

Count

hsa04660

T cell receptor signaling pathway

0.017549

PAK4/VAV3

2

hsa05206

MicroRNAs in cancer

0.021294

E2F3/PAK4/ZEB1

3

hsa04140

Autophagy - animal

0.027357

RRAGD/STK11

2

hsa04068

FoxO signaling pathway

0.028963

SETD7/STK11

2

hsa04150

mTOR signaling pathway

0.037997

RRAGD/STK11

2

2