WBC & PLATELETS ANOMALIESPRINCESS ALEN AGUILAR

WBC anomalies

Toxic granulation

• Dark blue-black cytoplasmic granules in neutrophil• Thought as primary granules• Show inc.alkaline phosphatase activity• Found in: acute infections

drug poisoning

burns

Dohle Bodies

• Single or multiple light blue or gray areas in cytoplasm of neutrophils• RER & represent failure of cytoplasm to mature• Found in: infections

poisoning

burns

following chemotherapy

Hypersegmented Neutrophils

• Neutrophils with six or more lobed nucleus• Represents an abnormality in maturation of neutrophil• Acquired(in megaloblastic erythropoiesis) or inherited(Undritz

anomaly)• Found in: pernicious anemia

folic acid deficiency

chronic infections

Barr Body

• Sex chromatin• Represents the second X chromosome in females (2-

3% of neutrophils in females)• Small,well-defined,round projection of nuclear

chromatin• These cells are not found in normal males.

Degenerated Neutrophil w/ pyknotic nucleus

• Result from condensing of nuclear chromatin into a solid structure mass with no pattern

• Not counted in differential cell count

Vacuolated neutrophil

• Degeneration of cytoplasm begins to acquire holes or as result of active phagocytosis

• May reflect increased lysosomal activity• Found in: septicemia

severe infection

Giant Neutrophils

• Can be seen occasionally in normal peripheral blood smear• Larger than normal neutrophils and genrally hyperlobulated• Found in frequency of 1 in every 20,000 neutrophils but

increase in disease states

Pelger-Huet Anomaly

• Indicates failure of neutrophil to segment properly

• Bi-lobed nucleus; chromatin is coarsely clumped

• May be inherited or acquired (as in leukemias)

• Heterozygous for this char.shows numerous bi-lobed (dumbell shape); homozygous-round neutrophil

Chediak-Higashi Syndrome(Autosomal recessive

disorder)• Rare,fatal disprder found in

children• Inherited as an autosomal

recessive char.• Contain very large,reddish-

purple or greenish-gray staining granules in the cytoplasm of granulocytes

• In monocytes & lymphocytes, stain bluish-purple

• These granules represent abnormal lysosomes

• Found in: anemia

neutropenia

thrombocytopenia

Alder-Reilly anomaly

• Heavy,coarse blue-black granules of BEN & sometimes lymphocytes & monocytes

• Inherited condition• Associated with Hurler’s

syndrome & Hunter’s syndrome

May-Hegglin Anomaly

• Inherited anomaly affecting neutrophils and platelets• Larger than usual Dohle-like bodies• Giant bizarre platelets is present & function may be

abnormal

Auer rods

• Rod-like bodies representing aggregated primary granules that stain reddish purple

• Found in : cytoplasm of myeloblast, monoblast and promyelocytes in acute monocytic or acute myelogenous leukemia and eythroleukemia

Smudge or Basket cell

• Disintegrating nucleus of ruptured WBC

PLATELETS SATELLITOSIS

• Platelets encircling the peripheral borders of neutrophils

• This phenomenon is thought to be due to a serum factor which reacts in the presence of EDTA.