WAN-JU LI PERSONAL DATA University of Wisconsin-Madison Department of Orthopedics and Rehabilitation Department of Biomedical Engineering

1111 Highland Ave. WIMR 5051 Madison, WI 53705 (608) 263-1338 li@ortho.wisc.edu EDUCATION 1993 BS (Biomedical Engineering), Chung-Yuan University, Chung Li, Taiwan

1999 MS (Biomedical Engineering), Drexel University, Philadelphia, Pennsylvania

2004 PhD (Cell and Tissue Engineering), Thomas Jefferson University, Philadelphia, Pennsylvania

2004-2008 Postdoc (National Institute of Arthritis and Musculoskeletal and Skin Diseases), National Institutes of Health, Bethesda, Maryland

PRESENT APPOINTMENTS/POSITIONS 2016-present Associate Professor, Department of Orthopedics and Rehabilitation, University of Wisconsin-

Madison, Madison, WI

2016-present Associate Professor, Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI

2008-present Trainer, Cellular and Molecular Biology Program, University of Wisconsin-Madison, Madison, WI 2008-present Affiliated Faculty, Materials Science Program, University of Wisconsin-Madison, Madison, WI

2008-present Affiliated Faculty, Stem Cell & Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI

2008-present Affiliated Faculty, Biomedical Engineering for Translational Research, University of Wisconsin-Madison, Madison, WI

PAST APPOINTMENTS/POSITIONS 1992-1993 Research Assistant, Department of Orthopedics, National Taiwan University Hospital, Taipei,

Taiwan

1995-1996 Research Assistant, Department of Orthopedics, National Taiwan University Hospital, Taipei, Taiwan

1997-1999 Research Assistant, School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA

1999-2001 Research Assistant, Cell and Tissue Engineering Program, Thomas Jefferson University, Philadelphia, PA

2001-2004 Graduate Fellow, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

2003-2005 Visiting Fellow, Polymer Division, Materials Science and Engineering Laboratory, National Institute of Standards and Technology, Gaithersburg, MD

2004-2006 Postdoctoral Fellow, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

2006-2008 Research Fellow, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

2008-2016 Assistant Professor, Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI

2008-2016 Assistant Professor, Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI

PROFESSIONAL SOCIETY MEMBERSHIPS 2008-present Orthopaedic Research Society

2008-present Biomedical Engineering Society

2008-present Tissue Engineering International & Regenerative Medicine Society

2008-present American Society for Cell Biology

2010-present International Society for Stem Cell Research

2010-present American Society for Bone and Mineral Research HONORS AND AWARDS 2004 Outstanding Graduate Research, National Institutes of Health

2004 Fellow Award for Research Excellence, National Institutes of Health

2006 Outstanding Poster Presentation Award, Annual Intramural Scientific Meeting of National Institute of Arthritis and Musculoskeletal and Skin Diseases

2007 Best Presentation Award, Annual Meeting of Society for Physical Regulation in Biology and Medicine

2008 Young Investigator Research Award, North American Spine Society

2010 Hilldale Undergraduate/Faculty Research Award

2011 Translational Research Pilot Award, UW Institute for Clinical and Translational Research

2013 Nontenured Faculty Award, 3M

2015 Emerging Investigator Award, Stem Cell Research & Therapy

2015 New Investigator Recognition Award, Annual Meeting of Orthopaedic Research Society

2015 Visiting Professor, Zhengzhou University, China

GRANT SUPPORT Current Support

1) Title: Biomaterials for Local Regulation of Growth Factor Signaling

Source: NIH/NHLBI Role: Co-Investigator (PI: William Murphy) Dates: 07/01/2015-06/30/2019 Amount: $1,870,100 Description: This proposed research program will develop a new class of materials that can be used

to control the effects of growth factors during stem cell culture and engineered tissue development, particularly vascular tissue development.

2) Title: Blood-derived Induced Pluripotent Stem Cells for Cartilage Repair

Source: NIH/NIAMS Role: Principal Investigator (Co-I: Igor Slukvin, Mark Markel, Marcus Cicerone) Dates: 08/01/2015-07/31/2020 Amount: $1,891,300 Description: The objective of this proposal is to develop an effective tissue engineering therapy for

treatment of osteoarthritis by exploring the potential of using iPSC-derived MSCs to generate engineered cartilage in vitro as an implant for cartilage repair in vivo.

Past Support 1) Title: A Novel Biomimetic Allograft Bone Powder-Nanofibrous Scaffold Bone Substitute

Source: Musculoskeletal Transplant Foundation Role: Investigator (PI: Leon Nesti) Dates: 01/01/2006-12/31/2006 Amount: $120,000 Description: This goal of this study is to tissue engineer bone in vitro using human mesenchymal

stem cells, biodegradable nanofibers, and human bone powders.

2) Title: Intervertebral Disc Regeneration from Co-cultured Disc and Stem Cells in Biomimetic Engineered Extracellular Matrix Stimulated by Mechanically Active Bioreactor

Source: North American Spine Society (Young Investigator Award) (133-PRJ19VR) Role: Principal Investigator Dates: 09/01/2008-08/31/2011 Amount: $49,000 Description: The goal of this study is to tissue engineer intervertebral disc using a biomimetic

nanofiber/hyaluronic acid gel composite structure.

3) Title: Biphasic Nanofiber/bone Powder Implants Grown in a Compressive Bioreactor for Osteochondral Repair

Source: AO Foundation (S-09-43L) Role: Principal Investigator (Co-I: Mark Markel) Dates: 09/01/2009-08/31/2012 Amount: $120,000 Description: The goal of this study is to tissue engineer biphasic osteochondral implants based on

mesenchymal stem cell-laden nanofibrous scaffolds cultured in a compressive loading-active bioreactor.

4) Title: Cell-based Tissue Regeneration using Elastin-mimetic Extracellular Matrix Protein Source: The Ministry of Education, Science and Technology of the Republic of Korea (10-BD-02) Role: Principal Investigator (Co-PI: Won Bae Jeon) Dates: 09/01/2011-12/31/2012 Amount: $260,000 Description: This study investigates the potential of elastin-mimetic extracellular matrix (EMECM)

protein as a novel biomaterial for stem cell-based musculoskeletal regeneration.

5) Title: Induced Pluripotent Stem Cells Differentiated in Engineered Matrix with a Bio-inspired Surface for Tendon Regeneration

Source: UW Institute for Clinical and Translational Research and UW Stem Cell & Regenerative Medicine Center (233-PRJ51ZA)

Role: Principal Investigator (Co-I: Igor Slukvin, William Murphy, and Ray Vanderby) Dates: 09/01/2011-08/31/2013 Amount: $50,000 Description: This study investigates tendon regeneration from stem cells induced and cultured in

braided nanofibrous scaffolds (BNFSs). 6) Title: High-throughput Perfusion Culture System

Source: UW-Madison Graduate School (101-PRJ61XE) Role: Principal Investigator (Co-I: Tomas Yen and Steven Goodman) Dates: 07/01/2012-06/30/2013 Amount: $50,000 Description: This study is to develop and fabricate a high-throughput culture system with a perfusion

capacity to enhance growth and differentiation of stem cell pellets.

7) Title: TGFB1 and BMP7 Regulation of Chondrogenesis in Mesenchymal Stem Cells Derived from Embryonic Stem Cells

Source: UW-School of Medicine and Public Health (233-PRJ73KV) Role: Principal Investigator Dates: 07/01/2013-06/30/2014 Amount: $30,000 Description: This study aims to elucidate the mechanism underlying chondrogenesis of ESC-derived

MSCs induced by TGFB1 and BMP7.

8) Title: Induced Pluripotent Stem Cells Differentiated in Engineered Matrix with a Bio-inspired Surface for Tendon Regeneration – in vivo study

Source: UW Institute for Clinical and Translational Research and UW Stem Cell & Regenerative Medicine Center (233-PRJ75AR)

Role: Principal Investigator (Co-I: Igor Slukvin, William Murphy, and Ray Vanderby) Dates: 08/01/2013-07/31/2014 Amount: $30,000 Description: This study investigates repair of tendon defects by tissue-engineered tendon derived

from human iPSCs in rabbits.

9) Title: Blood-derived Induced Pluripotent Stem Cells for Cartilage Repair Source: Wisconsin Alumni Research Foundation (135-PRJ85UL) Role: Principal Investigator

Dates: 06/26/2014-06/30/2015 Amount: $45,000

10) Title: hECM for Intervertebral Disc Tissue Engineering Source: PUR Biologics (MSN187773) Role: Principal Investigator Dates: 07/01/2015-12/31/2015 Amount: $15,000 Description: This study aims to tissue engineer an intervertebral disc (IVD) using human

mesenchymal stem cells (hMSCs) and annulus fibrosus cells (AFCs) or nucleus pulposus cells (NPCs) cocultured in a hECM-based composite scaffold.

11) Title: Braided Nanofibers and Embryonic Stem Cells for Ligament Tissue Engineering

Source: 3M (Nontenured Faculty Award) (233-PRJ71FE) Role: Principal Investigator Dates: 03/01/2013-02/28/2016 Amount: $45,000 Description: The goal of this study is to tissue engineer functional ligaments using braided nanofibers

and embryonic stem cells.

PUBLICATIONS Papers published in, or accepted by, refereed journals 2001 1) Caterson EJ, Nesti LJ, Li WJ, Danielson KG, Albert TJ, Vaccaro AR, Tuan RS. Three-dimensional

cartilage formation by bone marrow-derived cells seeded in polylactide/alginate amalgam. J Biomed Mater Res. 2001; 57:394-403.

2002 2) Caterson EJ, Li WJ, Nesti LJ, Albert T, Danielson KG, Tuan RS. Polymer/alginate amalgam for cartilage-

tissue engineering. Ann N Y Acad Sci. 2002; 961:134-138. 3) Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK. Electrospun nanofibrous structure: A novel scaffold

for tissue engineering. J Biomed Mater Res. 2002; 60:613-621. This paper is one of the first reports describing the technology in the field of tissue engineering and has

been cited more than 1,209 times according to the Journal Citation Reports. This paper was also selected as the top 25 papers of the Journal of Biomedical Materials Research published in its more than 50 years.

2003 4) Li WJ, Danielson KG, Alexander PG, Tuan RS. Biological response of chondrocytes cultured in three-

dimensional nanofibrous poly(ε-caprolactone) scaffolds. J Biomed Mater Res. 2003; 67A:1105-1114.

This paper is another highly cited report describing the new findings of a study using the new nanostructure for cartilage tissue engineering and has been cited more than 306 times by May 2015 according to the Journal Citation Reports.

5) Tuli R, Li WJ, Tuan RS. Current state of cartilage tissue engineering. Arthritis Res. Ther 2003; 5:235-238.

2004 6) Tuli R, Nandi S, Li WJ, Tuli S, Huang X, Manner P, Laquerriere P, Nöth U, Tuan RS. Human

mesenchymal progenitor cell-based tissue engineering of a single-unit osteochondral construct. Tissue Eng 2004; 10:1169-1179.

2005 7) Li WJ, Tuli R, Okafor C, Derfoul A, Danielson KG, Hall DJ, Tuan RS. A three-dimensional nanofibrous

scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials 2005; 26:599-609.

This paper has been cited 484 times by May 2015, highlighted as Highly Cited Paper in Journal Citation Reports. It ranked the 1st of the Top 25 Cited Articles of Biomaterials between July and December 2004, and the 2nd, 7th, and 3rd between January and December 2005.

8) Li WJ, Tuli R, Huang X, Laquerriere P, Tuan RS. Multilineage differentiation of human mesenchymal

stem cells in a three-dimensional nanofibrous scaffold. Biomaterials 2005; 26:5158-5166. This paper has been cited 342 times by May 2015, highlighted as Highly Cited Paper in Journal Citation

Reports. It ranked the 2nd of the Top 25 Cited Articles of Biomaterials between April and June 2005. 9) Li WJ, Mauck RL, Tuan RS. Electrospun nanofibrous scaffolds: production, characterization, and

applications for tissue engineering and drug delivery. J Biomed Nanotechnology 2005; 1:259-275. 10) Li WJ, Tuan RS. Polymeric scaffolds for cartilage tissue engineering. Macromolecular Symposia 2005;

227:65-75. 2006 11) Kuo CK, Li WJ, Mauck RL, Tuan RS. Cartilage tissue engineering: its potential and uses. Curr Opin

Rheumatol 2006; 18:64-73. 12) Li WJ, Cooper JA, Mauck RL, Tuan RS. Fabrication and characterization of six electrospun poly(alpha-

hydroxy ester) based fibrous scaffolds for tissue engineering. Acta Biomaterialia 2006; 2:377-385.

This paper has been cited 229 times by May 2015, highlighted as Highly Cited Paper in Journal Citation Reports. It ranked the 6th of the Top 25 Cited Articles of Acta Biomaterialia between April and June 2006, and the 3rd between July and September 2006.

13) Li WJ, Jiang, YJ, Tuan RS. Chondrocyte phenotype in engineered fibrous matrix is regulated by fiber

size. Tissue Eng 2006; 12:1775-1785. 2007 14) Cooper JA, Li WJ, Bailey LO, Hudson SD, Lin-Gibson S, Anseth KS, Tuan RS, Washburn NR.

Encapsulated chondrocyte response to pulsatile flow bioreactor. Acta Biomaterialia 2007; 3:13-21.

15) Christenson EM, Anseth KS, van de Beucken JJ, Chan CK, Ercan B, Jansen JA, Laurencin CT, Li WJ, Murugan R, Nair LS, Ramakrishna S, Tuan RS, Webster TJ, Mikos AG. Nanobiomaterial applications in orthopaedics. J Orthop Res 2007; 25:11-22.

16) Nesti LJ, Caterson EJ, Li WJ, Chang R, D. McCannl, Hoek JB, Tuan RS. TGF-b1 calcium signaling in

osteoblasts. J Cell Biochem 2007; 101:348-359. 17) Cho E, Li WJ. Human stem cells, chromatin, and tissue engineering: boosting relevancy in

developmental toxicity testing. Birth Defects Res C Embryo Today 2007; 81:20-40. 18) Li WJ, Mauck RL, Cooper JA, Yuan X, Tuan RS. Engineering controllable anisotropy in electrospun

biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. J Biomech 2007; 40:1686-1693.

19) Shanti RM, Li WJ, Nesti LJ, Wang X, Tuan RS. Adult mesenchymal stem cells: biological properties,

characteristics, and applications in maxillofacial surgery. J Oral Maxillofac Surg 2007; 65:1640-1647. 2008 20) Li WJ, Jiang YJ, Tuan RS. Cell-nanofiber-based cartilage tissue engineering using improved cell

seeding, growth factor, and bioreactor technologies. Tissue Eng 2008; 14:639-648. 21) Janjanin S, Li WJ, Morgan, MT, Shanti R, Tuan RS. Mold-shaped, nanofiber scaffold-based cartilage

engineering using human mesenchymal stem cells and bioreactor. J Surg Res 2008; 149:47-56. 22) Nesti LJ, Li WJ, Shanti RM, Jiang YJ, Jackson W, Freedman BA, Kuklo TR, Giuliani JR, Tuan RS.

Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam. Tissue Eng Part A 2008; 14:1527-1537.

23) Shanti RM, Janjanin S, Li WJ, Nesti LJ, Mueller MB, Tzeng MB, Tuan RS. In vitro adipose tissue

engineering using an electrospun nanofibrous scaffold. Ann Plast Surg 2008; 61:566-571. 2009 24) Li WJ, Chiang H, Kuo TF, Lee HS, Jiang CC, Tuan RS. Evaluation of articular cartilage repair using

biodegradable nanofibrous scaffolds in a swine model: a pilot study. J Tissue Eng Regen Med 2009; 3:1-10.

25) Tsai MT, Li WJ, Tuan RS, Chang WH. Modulation of osteogenesis in human mesenchymal stem cells by

specific pulsed electromagnetic field stimulation. J Ortho Res 2009; 27:1169-1174. 26) Wan X, Kim SY, Guenther LM, Mendoza A, Briggs J, Yeung C, Currier D, Zhang H, Mackall C, Li WJ,

Tuan RS, Deyrup AT, Khanna C, Helman L. Beta4 integrin promote osteosarcoma metastasis and interacts with ezrin. Oncogene 2009; 28:3401-3411.

27) Mauck RL, Baker BM, Nerurkar NL, Burdick JA, Li WJ, Tuan RS, Elliott DM. Engineering on the straight

and narrow: the mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration. Tissue Eng Part B Rev 2009; 15:171-193.

28) Baker BM, Handorf AM, Ionescu LC, Li WJ, Mauck RL. New directions in nanofibrous scaffolds for soft

tissue engineering and regeneration. Expert Rev Med Devices 2009; 6:515-532.

2010 29) Barber JG, Li WJ. Nanostructured scaffolds for biology and tissue engineering. Nano Life 2010; 1&2:109-

120. 2011 30) Handrof AM, Li WJ. Fibroblast growth factor-2 primes human mesenchymal stem cells for enhanced

chondrogenesis. PLoS One 2011; 6:e22887. 31) Giri J, Li WJ, Tuan RS, Cicerone MD. Stabilization of proteins by nanoencapsulation in sugar-glass for

tissue engineering and drug delivery applications. Adv Mater 2011; 23:4861-4867. 2012 32) Cui ZX, Nelson B, Peng YY, Li K, Pilla S, Li WJ, Turng LS, Shen CY. Fabrication and characterization of

injection molded poly(epsilon-caprolactone) and poly(epsilon-caprolactone)/hydroxyaptite scaffolds for tissue engineering. Mater Sci Eng C Mater Biol Appl 2012; 32:1674-1681.

33) Koepsel JT, Brown PT, Loveland SG, Li WJ, Murphy WL. Combinatorial screening of chemically defined

human mesenchymal stem cell culture substrates. J Mater Chem 2012; 22:19474-19481. 2013 34) Tsai TL, Manner PA, Li WJ. Regulation of mesenchymal stem cell chondrogenesis by glucose through

protein kinase C/Transforming growth factor signaling. Osteoarthritis Cartilage 2013; 21:368-376. 35) Barber JG, Handorf AM, Allee TJ, Li WJ. Braided nanofibrous scaffold for tendon and ligament tissue

engineering. Tissue Eng Part A 2013; 19:1265-1274. 36) Brown PT, Handorf AM, Jeon WB, Li WJ. Stem cell-based tissue engineering approaches for

musculoskeletal regeneration. Curr Pharm Des 2013; 19: 3429-3445. 37) Palumbo SL, Li WJ. Osteoprotegerin enhances osteogenesis of human mesenchymal stem cells. Tissue

Eng Part A 2013; 319:1942-1955. 38) Pflum ZE, Palumbo SL, Li WJ. Adverse effect of demineralized bone powder on osteogenesis of human

mesenchymal stem cells. Exp Cell Res 2013; 319:1942-1955. This paper was selected as a highlighted article in the section of Stem Cells by World Biomedical

Frontiers in November 2013. 2014 39) Saether EE, Chamberlain CS, Leiferman EM, Kondratko-Mittnacht JR, Li WJ, Brickson SL, Vanderby R.

Enhanced medial collateral ligament healing using mesenchymal stem cells: dosage effects on cellular response and cytokine profile. Stem Cell Rev 2014; 10:86-96.

40) Handorf AM, Li WJ. Induction of mesenchymal stem cell chondrogenesis through sequential

administration of growth factors within specific temporal windows. J Cell Physio 2014; 229:162-171.

41) Palumbo S, Tsai TL, Li WJ. Macrophage migration inhibitory factor regulate Akt signaling in hypoxic

culture to modulate senescence of human mesenchymal stem cells. Stem Cells Dev 2014; 23:852-865. This paper was recommend by F1000 Rheumatology & Clinical Immunology for reading. 42) Tsai TL, Nelson BC, Anderson PA, Zdeblick TA, Li WJ. Intervertebral disc and tem cells co-cultured in

biomimetic extracellular matrix stimulated by cyclic compression in perfusion bioreactor. Spine J 2014; 14:2127-2140.

43) Czaplewski SK, Tsai TL, Duenwald-Kuehl SE, Vanderby R Jr, Li WJ. Tenogenic differentiation of human

induced pluripotent stem cell-derived mesenchymal stem cells dictated by properties of braided nanofibrous scaffolds. Biomaterials 2014; 35:6907-6917.

This paper was highlighted as special interest in the drug development sector and an advancement in

medicine by Global Medical Discovery. 44) Brown PT, Squire MW, Li WJ. Characterization and evaluation of mesenchymal stem cells derived from

human embryonic stem cells and bone marrow. Cell Tissue Res 2014; 358:149-164. 45) Mi HY, Palumbo S, Jing X, Turng LS, Li WJ, Peng XF. Thermoplastic polyurethane/hydroxyapatite

electrospun scaffolds for bone tissue engineering: effect of polymer properties and particle size. J Biomed Mater Res Part B 2014; 102:1434-1444.

2015 46) Handorf AM, Chamberlain CS, Li WJ. Endogenously-produced Indian hedgehog regulates TGFB-driven

chondrogenesis of human bone marrow stromal/stem cells. Stem Cells Dev 2015; 24:995-1007. 47) Handorf AM, Zhou Y, Halanski MA, Li WJ. Tissue stiffness dictates development, homeostasis, and

disease progression. Organogenesis 2015; 11:1-15. 48) Tsai TL, Wang B, Squire MW, Guo LW, Li WJ. Endothelial cells direct human mesenchymal stem cells

for osteo- and chondro-lineage differentiation through endothelin-1 and AKT signaling. Stem Cell Res Ther 2015; 6:88.

This paper is part of the ‘Emerging Investigators’ collection of Stem Cell Research & Therapy and was

also recommend by F1000 Rheumatology & Clinical Immunology for reading. 49) Jing X, Jin E, Mi HY, Li WJ, Peng XF, Turng LS. Hierarchically decorated electrospun poly(ε-

caprolactone)/nanohydroxyapatite composite nanofibers for bone tissue engineering. J Mater Sci 2015; 50:4174-4186.

50) Chiu CY, Tsai TL, Vanderby R, Bradica G, Lou SL, Li WJ. Osteoblastogenesis of mesenchymal stem

cells in 3-D culture enhanced by low-intensity pulsed ultrasound through soluble receptor activator of nuclear factor kappa B ligand. Ultrasound Med Bio 2015; 41:1842-1852.

2016 51) Zhou Y, Zimber M, Yuan H, Naughton GK, Fernan R, Li WJ. Effects of human fibroblast-derived

extracellular matrix on mesenchymal stem cells. Stem Cell Rev 2016; 12:560-572.

52) Yuan H, Zhou Y, Lee MS, Zhang Y, Li WJ. A newly identified mechanism involved in regulation of human

mesenchymal stem cells by fibrous substrate stiffness. Acta Biomater 2016; 42:247-257. 53) Jin E, Lee PT, Jeon WB, Li WJ. Effects of elastin-like peptide on regulation of human mesenchymal stem

cell behavior. Regen Eng Transl Med 2016; 2:85-97. 54) Chaudhary R, Lee MS, Mubyana K, Duenwald-Kuehl S, Kaiser J, Vanderby R, Eliceiri KW, Corr DT, Li

WJ, Campagnola PJ, Halanski MA. The role of periosteal fibers in accelerated bone growth. Bone 2016; 92:201-213.

2017 55) Lee PT, Li WJ. Chondrogenesis of embryonic stem cell-derived mesenchymal stem cells induced by

TGFB1 and BMP7 through increased TGFB receptor expression and endogenous TGFB1 production. J Cell Biochem 2016; 118:172-181.

56) Tsai TL, Li WJ. Identification of Bone Marrow-derived Soluble Factors Regulating Human Mesenchymal Stem Cells for Bone Regeneration. Stem Cell Reports 2017; 8:387-400.

Chapters in books 1) Li WJ, Shanti RM, Tuan RS. Electrospinning technology for nanofibrous scaffolds in tissue engineering.

In: Challa S.S.R. Kumar, editor. Nanotechnologies for the Life Sciences. Germany: Wiley-VCH Verlag GmbH & Co. KgaA, 2006; 135-187.

2) Chen FH, Song L, Mauck RL, Li WJ, Tuan RS. Mesenchymal stem cells in musculoskeletal tissue

engineering. In: Robert Lanza, Robert Langer, and Joseph P. Vacanti, editors. Principles of Tissue Engineering, Third Edition. Academic Press, 2007; 823-844.

3) Li WJ, Gollapudi K, Patterson DP, Huang GT, Tuan RS. Cell-based therapies for musculoskeletal repair.

In: Anthony Atala, Robert Lanza, James A. Thomson, and Robert M. Nerem, editors. Principles of Regenerative Medicine, Elsevier, 2008; 888-911.

4) Mauck RL, Li WJ, Tuan RS. Microenvironmental determinants of stem cell fate: implications for

musculoskeletal tissue engineering. In: Ulrich Meyer, Jorg Handschel, Hans Peter Wiesmann, and Thomas Meyer, editors. Fundamentals of Tissue Engineering and Regenerative Medicine: Springer, 2009; 529-545.

5) Li WJ and Tuan RS. Fabrication and application of nanofibrous scaffolds in tissue engineering. Current

Protocols in Cell Biology: John Wiley & Sons, 2009; Unit 25.2. 6) Allee T, Handorf AM, Li WJ. Electrospinning: development and biomedical applications. In: Anupam

Shukla and Ritu Tiwari, editors. Intelligent Medical Technologies and Biomedical Engineering: Tools and Applications. IGI Global, 2010; 48-78.

7) Li WJ and Cooper JA. Fibrous scaffolds for tissue engineering. In: Jason Burdick and Robert Mauck,

editors. Biomaterials for Tissue Engineering: A Review of the Past and Future Trends. SpringerWienNew York 2011; 47-73.

8) Cooper JA, Mintz BR, Palumbo SL, Li WJ. Assays for determining cell differentiation in biomaterials. In: Jaffe M, Hammond W, Tolias P, and Arinzeh T, editors. Characterization of Biomaterials. Woodhead Publishing 2013; 101-137.

9) Kuo CK, Li WJ, Tuan RS. Cartilage and ligament tissue engineering: biomaterials, cellular interactions,

and regenerative strategies. In: Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, and Jack E. Lemons, editors. Biomaterials Science: An Introduction to Materials in Medicine, 3rd edition. Academic Press 2013; 1214-1236.

10) Handorf AM, Brown PT, Barber JG, Li WJ. Regulation of stem cell behavior using nanobiomaterials. In:

Murugan Ramalingam, Pekka Vallittu, Ugo Ripamonti, and Wan-Ju Li, editors. Tissue Engineering and Regenerative Medicine: A Nano Approach, CRC Press 2013; 299-319.

11) Jin E and Li WJ. Modulating and Turning Synthetic Extracellular Matrix Mechanics. In: Gregory Hudalla

and William Murphy, editors. Mimicking the Extracellular Matrix: The Intersection of Matrix Biology and Biomaterials, Royal Society of Chemistry 2016; 195-216.

Conference abstracts 1) Ko FK, Li WJ, Laurencin CT. Electrospun nanofibrous structure for tissue engineering. Sixth World

Biomaterials Congress, May 2000, Kamuela, HI 2) Caterson EJ, Li WJ, Nesti LJ, Albert T, Danielson K, Tuan RS. Chondrogenic tissue engineering

constructs of human marrow stromal cells loaded into PLA and PLA/alginate amalgams. Advances in Tissue Engineering for the treatment of Arthritic Diseases. September 2000, Boston, MA.

3) Caterson, EJ, Li WJ, Nesti LJ, Strachan G, Albert T, Danielson K, Tuan RS. Chondrogenic differentiation

and proliferation properties of human mesenchymal stem cells on PLA polymer scaffolds and PLA polymer/alginate amalgams. 2001 Trans ORS 47:602.

4) Caterson EJ, Li WJ, Nesti LJ, Albert T, Danielson K, Tuan RS. Tissue engineering constructs of PLA and

PLA/alginate amalgams and human marrow stromal cells. Sigma Xi 2001, Thomas Jefferson University, Philadelphia, PA.

5) Caterson EJ, Li WJ, Nesti LJ, Albert T, Danielson K, Tuan RS. Polymer/alginate amalgam for cartilage

tissue engineering. NIH BECON “Reparative Medicine: Growing Tissues and Organs”. 2001, Bethesda, MD.

6) Li WJ, Danielson KG, Tuan, RS. Biodegradable nanofibrous scaffolds for cartilage tissue engineering.

The 2002 NICHD Scientific Retreat. Harpers Ferry, WV. 7) Li WJ, Danielson KG, Tuan RS. Biodegradable nanofibrous scaffolds for cartilage tissue engineering.

The 2002 NIAMS Scientific Retreat. June 2002, Airlie House, VA. 8) Li WJ, Tuli R, Danielson KG, Hall DJ, Tuan RS. Human bone marrow derived mesenchymal progenitor

cells cultured in biodegradable nanofibrous scaffolds for cartilage tissue engineering. Tissue Engineering Meeting, November, 2002, Cold Spring Harbor, NY.

9) Li WJ, Denielason KG, Tuan RS. Biological response of chondrocytes cultured in an electrospun three-

dimensional poly(ε-carprolactone) scaffold. The 49th annual meeting of Orthopaedic Research Society, February 2003, New Orleans, LA.

10) Li WJ, Tuli R, Huang X, Laquerriere P, Danielson KG, Hall DJ, Tuan RS. A three-dimensional poly(ε-

Caprolactone) based nanofibrous scaffold supports the multilineage differentiation potential of human mesenchymal stem cells. The ISSCR First Annual Meeting, June 2003, Washington, DC.

11) Li WJ, Tuli R, Okafor A, Derfoul A, Danielson KG, Hall DJ, Tuan RS. Human bone marrow derived

mesenchymal stem cells cultured in a three-dimensional poly(Epsilon-caprolactone) nanofibrous scaffold for cartilage tissue engineering. NIH Research Festival, October 2003, Bethesda, MD.

12) Li WJ, Tuli R, Huang X, Danielson KG, Hall DJ, Tuan RS. A three-dimensional poly(ε-caprolactone)

nanofibrous scaffold supports the multilineage differentiation of human mesenchymal stem cells. November 2003, Orlando, FL.

13) Li WJ, Jiang YJ, Tuan RS. Novel Cartilage tissue engineering using chondrocyte-loaded nanofibrous

composite. The Strategies in Tissue Engineering, June 2004. Wurzburg, Germany. 14) Li WJ, Jiang YJ, Tuan RS. Evaluation of fibrous tissue engineering scaffolds of varying structural

properties for cartilage tissue engineering. The 2004 Gordon Research Conference: Signal Transduction by Engineered Extracellular Matrices, June 2004, ME.

15) Li WJ, Cooper JA, Mauck, RL, Cicerone MT, Tuan RS. Characterization of electrospun poly(alpha-

hydroxy ester) based nanofibrous scaffolds. 2004 Polymer Networks Conference, August 2004, Bethesda, MD.

16) Li WJ, Mauck RL, Yuan X, Cooper JA, Tuan RS. Engineering anisotropic electrospun biodegradable

nanofibrous scaffolds for musculoskeletal tissue engineering. 5th Combined Meeting of the Orthopaedic Research Societies, October 2004, Banff, Canada.

17) Washburn NR, Weir MD, Li WJ, Tuan RS. Combinatorial screening of chondrocyte response to tissue

engineering hydrogels. The 7th World Biomaterials Congress, May 2004, Sidney, Australia. 18) Cicerone MT, Li WJ, Tuan RS, Soles CL, Vogel BM. Sustained delivery of stabilized proteins from

electrospun tissue scaffolds. The 7th World Biomaterials Congress, May 2004, Sidney, Australia. 19) Li WJ, Mauck RL, Cooper JA, Tuan RS. Engineering anisotropy in electrospun biodegradable

nanofibrous scaffolds for musculoskeletal tissue engineering. NIH Research Festival, October 2004, Bethesda, MD.

20) Li WJ, Jiang YJ, Tuan RS. Novel Cartilage Tissue engineering using chondrocyte-loaded nanofibrous

composite. 2004 National Institute of Arthritis and Musculoskeletal and Skin Diseases Retreat, June 2004, PA.

21) Li WJ, Jiang YJ, Tuan RS. Evaluation of fibrous tissue engineering scaffolds of varying structural

properties for cartilage tissue engineering. 2004 National Institute of Arthritis and Musculoskeletal and Skin Diseases Retreat, June 2004, PA.

22) Jiang YJ, Li WJ, Tuan RS. Effects of growth factors on chondrocyte-loaded nanofibrous composite. NIH

Postbaccalaureate Poster Day, May 2004, Bethesda, MD.

23) Li WJ, Jiang Y J, Tuan R S. Chondrocyte-loaded nanofibrous composites for cartilage tissue engineering. The 51st Annual Meeting of the Orthopedics Research Society, February 2005, Washington, DC.

24) Li WJ, Song L, Tuan RS. Comparison of global gene expression profiles of human mesenchymal stem

cells in 2D and 3D culture substrate. 2005 National Institute of Arthritis and Musculoskeletal and Skin Diseases Scientific Retreat, June 2005, Rockville, MD.

25) Mauck RL, Li WJ, Yuan X, Tuan RS. Meniscus tissue engineering with anisotropic biodegradable

nanofibrous poly-caprolactone scaffolds. The 51st Annual Meeting of the Orthopedics Research Society, February 2005, Washington, DC.

26) Nesti LJ, Li WJ, Freedman BA, Jiang Y, Kuklo TR, Tuan RS. A novel nanofiber-gel scaffold for use in

intervertebral disc tissue engineering. Soc Mil Orthop Surg, 2005. 27) Nesti LJ, Li WJ, Freedman BA, Jiang Y, Kuklo TR, Tuan RS. Novel nanofibrous intervertebral disc

construct supports cell growth and matrix production. North American Spine Society (NASS), 2005. 28) Shanti RM, Li WJ, Nesti LJ, Jiang Y, Tuan RS. Myogenic differentiation of human mesenchymal stem

cells in a 3D nanofibrous scaffold. Annual Meeting of the Biomedical Engineering Society, September 2005, Baltimore, MD.

29) Nesti LJ, Shanti RM, Li WJ, Jiang Y, Tuan RS. Multipotential cells derived from human skeletal muscle.

National Institute of Arthritis and Musculoskeletal and Skin Diseases Scientific Retreat, June 2005, Rockville, MD.

30) Shanti RM, Li WJ, Nesti LJ, Tuan RS. In vitro skeletal muscle tissue using human bone marrow derived

mesenchymal stem cells in a three-dimensional poly(ε-caprolactone) nanofibrous scaffold. 2nd Morphogenesis & Regenerative Medicine Symposium, May 2005, Charlottesville, VA.

31) Jiang YJ, Li WJ, Tuan RS. 2005 Optimization of chondrocyte-loaded nanofibrous composite. 2nd

Morphogenesis & Regenerative Medicine Symposium, May 2005, Charlottesville, VA. 32) Shanti RM, Li WJ, Tuan RS. Electrospun three-dimensional polycaprolactone nanofibers: candidate

scaffold for skeletal muscle tissue engineering. Howard Hughes Medical Institute Meeting of Medical Student Fellows, 2005, Chevy Chase, MD.

33) Nesti LJ, Li WJ, Freedman B, Shanti RM, Jiang Y, Kuklo TR, Tuan RS. The potential of a novel

hyaluronic acid nanofibrous scaffold (HANFS) amalgam in intervertebral disc tissue engineering. Meeting of the Washington Orthopaedic Society, 2005, Washington, DC.

34) Li WJ, Jiang YJ, Galbán CJ, Fishbein KW, Maher SA, Spencer RG, Tuan RS. Integration promotion,

evaluation of nanofiber-based engineered cartilage and native cartilage. 52nd Annual Meeting of the Orthopaedic Research Society, 2006, Chicago, IL.

35) Shanti RM, Li WJ, Nesti LJ, Jiang Y, Tuan RS. Electrospun three-dimensional poly(L-Lactic Acid)

nanofibers as a potential scaffold for skeletal muscle tissue engineering. 52nd Annual Meeting of the Orthopaedic Research Society, 2006, Chicago, IL.

36) Nesti LJ, Li WJ, Shanti RM, Jiang Y, Freedman BA, Kuklo TR, Tuan RS. Novel HANFS amalgam for intervertebral disc tissue engineering. The 52nd Annual Meeting of the Orthopaedic Research Society, 2006, Chicago, IL.

37) Nesti LJ, Shanti RM, Li WJ, Jiang Y, Freedman BA, Kuklo TR, Doukas WC, Tuan RS. Multipotential cells

from traumatically injured orthopaedic patients as potential cell sources for tissue engineering applications. The 52nd Annual Meeting of the Orthopaedic Research Society, 2006, Chicago, IL.

38) Sheth NP, Li WJ, Tuan RS, Elliott DM, Huffman R, Mauck RL. Fixation anisotropic biodegradable

nanofibrous poly-caprolactone scaffolds to bovine meniscus with non-absorbable suture: a strategy for meniscus repair. The 52nd Annual Meeting of the Orthopaedic Research Society, 2006, Chicago, IL.

39) Mueller MB, Li WJ, Taboas JM, Tuan RS. Influence of cyclic hydrostatic pressure on the multilineage

differentiation of human mesenchymal stem cells. The 52nd Annual Meeting of the Orthopaedic Research Society, 2006, Chicago, IL.

40) Janjanin S, Li WJ, Shanti RM, Tuan RS. Mold-Shaped Nanofiber-Based Cartilage Engineering in a

Bioreactor for Nasal Reconstructive Surgery. The 1st Annual Methods in Bioengineering Conference, 2006, Cambridge, MA.

41) Shanti RM, Janjanin S, Li WJ, Nesti LJ, Mueller MB, Tzeng MB, Jiang YJ, Tuan RS. A Synthetic

Biocompatible Nanofibrous Scaffold for Adipose Tissue Engineering. The 1st Annual Methods in Bioengineering Conference, 2006, Cambridge, MA.

42) Li WJ, Jiang YJ, Galbán CJ, Fishbein KW, Maher SA, Spencer RG, Tuan RS. Evaluation of nanofiber-

based engineered cartilage and its integration with native cartilage. The 25th Scientific Conference of the Society for Physical Regulation in Biology and Medicine, 2007, Honolulu, HI.

43) Kim SY, Li WJ, Wincovitch SM, Darko IA, Hong SH, Khanna C, Tuan RS, Garfield SH, Helman LJ.

Modeling the tumor microenvironment in vitro using a bio-mimetic nanofiber scaffold. Am Assoc Cancer Res Annual Meeting, 2007, Los Angeles, CA.

44) Kim SY, Garfield SH, Wincovitch SM, Hong SH, Darko IA, Li WJ, Tuan RS, Khanna C, Helman LJ. A

three-dimensional biomimetic model of metastases. Pediatr Blood Cancer Annual Meeting, 2007, Toronto, Canada.

45) Cho E, Li WJ, Tuan RS. Chromatin, Human Stem Cells, and Tissue Engineering: Shifting Paradigms to

Improve Relevancy in Developmental Toxicology Research. Teratology Society Annual Meeting, 2007, Pittsburgh, PA.

46) Shanti RM, Steigman SA, Li WJ, Tuan RS, Ahmed A, Fauza DO. Human fetal bone engineering with

electrospun nanofibers and amniotic mesenchymal stem cells. The American Academy of Pediatrics Annual Meeting, 2007, San Francisco, CA.

47) Li WJ, Song J, Zhou J, Shanti R, Tuan RS. Biological activities of human mesenchymal stem cells in

nanofibrous matrix. The 26th Scientific Conference of the Society for Physical Regulation in Biology and Medicine, 2008, Miami, FL.

48) Nesti LJ, Li WJ, Jackson WM Tuan RS. Intervertebral disc tissue engineering using a novel composite

nanofibrous scaffold. NIH NanoWeek, 2009, Washington, DC.

49) Martin CA, Li WJ. Osteogenesis of mesenchymal stem cells regulated by extracellular matrix molecules. UW-Madison Undergraduate Symposium 2009, April 2009, Madison, WI.

50) Pflum ZE, Li WJ. The effects of dermineralized bone matrix on osteogenesis of human mesenchymal

stem cells. UW-Madison Undergraduate Symposium 2009, April 2009, Madison, WI. 51) Allee TJ, Li WJ. Novel biomimetic scaffold for tendon/ligament tissue engineering. Proceeding of ASME

2010 First Global Congress on NanoEngineering for Medicine and Biology, February 2010, Houston, TX. 52) Kramschuster A, Turng LS, Li WJ, Peng Y, Peng J. The effect of nano hydroxyapatite particles on

morphology and mechanical properties of microcellular injection molded polylactide/hydroxyapatite tissue scaffold. Proceeding of ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology, February 2010, Houston, TX.

53) Tsai DT, Palumbo SL, Manner PA, Li WJ. Temporal induction of diverse extracellular matrix proteins for

effective osteogenesis. The 56th Annual Meeting of the Orthopaedic Research Society, March 2010, New Orleans, LA.

54) Handorf AM, Li WJ. FGF-2 enhances hMSC chondrogenesis and accelerates cartilage matrix production

through both selection and priming mechanisms. The 56th Annual Meeting of the Orthopaedic Research Society, March 2010, New Orleans, LA.

55) Tsai DT, Manner PA, Li WJ. Glucose effect of pre-differentiation culture on chondrogenesis of human

mesenchymal stem cells. The 56th Annual Meeting of the Orthopaedic Research Society, March 2010, New Orleans, LA.

56) Tsai DT, Manner PA, Li WJ. Pre-differentiation TGF-beta receptor signaling regulation by glucose affects

human MSC chondrogenic capacity, The TERMIS North America 2010 Annual Conference, Orlando, FL, USA

57) Handorf AM, Li WJ. Enhancement of hMSC chondrogenesis through the sequential administration of

growth factors within specific temporal windows, The 57th Annual Meeting of the Orthopaedic Research Society, January 2011, Long Beach, CA.

58) Palumbo SL, Li WJ. Osteosarcoma cell conditioned medium effectively proliferates and differentiates

human mesenchymal stem cells, The 57th Annual Meeting of the Orthopaedic Research Society, January 2011, Long Beach, CA.

59) Brown PT, Slukvin I, Manner PA, Li WJ. Chondrogenic capability of human mesenchymal stem cells

derived from adult bone marrow and embryonic stem cells, The 57th Annual Meeting of the Orthopaedic Research Society, January 2011, Long Beach, CA.

60) Palumbo S, Li WJ. The role of FOXO3a in the regulation of human mesenchymal stem cell senescence

under hypoxia, The 9th Annual Meeting of the International Society for Stem Cell Research, June 2011, Toronto, Canada.

61) Handorf AM, Barber JG, Allee TJ, Li WJ. Mechanical stimulation provides the key induction signal for

tenogenic differentiation of human mesenchymal stem cells in braided nanofibrous scaffolds. ASME 2011 Summer Bioengineering Conference, June 2011, Farmington, PA.

62) Brown PT, Slukvin I, Li WJ. Comparison between embryonic stem cell- and adult bone marrow-derived mesenchymal stem cells for chondrogenesis, The 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, September 2011, Boston, MA.

63) John JG, Handorf AM, Li WJ. Braiding electrospun nanofibers for tendon/ligament tissue engineering,

The TAPPI 2011 NET Innovative Nonwovens Conference, September 2011, Atlanta, GA. 64) Handorf AM, Tsai TL, Squire MW, Li WJ. The Mechanisms of Fibroblast Growth Factor-2 and Glucose

Regulating the Chondrogenic Potential of Pre-differentiation Human Mesenchymal Stem Cells. The 1st World Congress on Cell Science and Stem Cell Research, November 2011, Philadelphia, PA.

65) Martin CA, Li WJ. Synergistic effect of surface topography and chemistry od extracellular matrix on

regulation of osteogenesis. The TERMIS North America 2011 Annual Conference, December 2011, Houston, TX.

66) Handorf AM, Li WJ. Articular chondrocytes differentiation from human mesenchymal stem cells through

the sequential administration of growth factors. The 58th Annual Meeting of the Orthopaedic Research Society, February 2012, San Francisco, CA.

67) Barber JG, Squire MW, Li WJ. BMP-7 enhances hMSC chondrogenesis and osteogenesis in an

osteochondral plug. The 58th Annual Meeting of the Orthopaedic Research Society, February 2012, San Francisco, CA.

68) Tsai TL, Wang AR, Squire MW, Li WJ. The role of mesenchymal stem cell in diabetic osteoporosis. The

58th Annual Meeting of the Orthopaedic Research Society, February 2012, San Francisco, CA. 69) Brown PT, Slukvin I, Squire MW, Li WJ. IGF-1 regulates chondrogenesis of mesenchymal stem cells

derived from embryonic stem cells. The 58th Annual Meeting of the Orthopaedic Research Society, February 2012, San Francisco, CA.

70) Pflum ZE, Palumbo SL, Squire MW, Tuan RS, Li WJ. Response of human mesenchymal stem cells

regulated by demineralized bone matrix. The 58th Annual Meeting of the Orthopaedic Research Society, February 2012, San Francisco, CA.

71) Palumbo SL, Squire MW, Li WJ. Osteoprotegrin (OPG) preconditions human mesenchymal stem cells

for enhanced osteogenic differentiation. The 58th Annual Meeting of the Orthopaedic Research Society, February 2012, San Francisco, CA.

72) Palumbo SL, Li WJ. Osteoprotegrin (OPG) secreted from osteoblasts stimulates human mesenchymal

stem cells for osteogenesis. American Society of Bone and Mineral Research 2012 Annual Meeting, October 2012, Minneapolis, MN.

73) Handorf AM, Li WJ. Deactivation of TGF-β signaling promotes the initiation of hypertrophic differentiation

during hMSC chondrogenesis. The 59th Annual Meeting of the Orthopaedic Research Society, January 2013, San Antonio, TX.

74) Barber JG, Lu Y, Markel MD, Li WJ. Tissue-engineered osteochondral construct generated by optimized

differentiation medium and compressive loading for sheep model. The 59th Annual Meeting of the Orthopaedic Research Society, January 2013, San Antonio, TX.

75) Chiu CY, Tsai TL, Vanderby R, Bradica G, Lou SL, Li WJ. Receptor activator of nuclear factor kappa-B ligand produced by ultrasounic stimulation enhances osteogenesis of mesenchymal stem cells. The BMES 2013 Annual Meeting, September 2013, Seattle, WA.

76) Chiu CY, Tsai TL, Vanderby R, Bradica G, Lou SL, Li WJ. Mechanical stimulation induces the production

of soluble RANKL to modulate osteogenesis of mesenchymal stem cells. American Society of Bone and Mineral Research 2013 Annual Meeting, October 2013, Baltimore, MD.

77) Palumbo SL, Li WJ. Osteogenesis of human mesenchymal stem cells enhanced by osteoprotegerin

through activation of nuclear factor-kappa B. Tissue Engineering and Regenerative Medicine International Society Americas Annual Conference 2013, November 2013, Atlanta, GA.

78) Tsai TL, Squire MW, Li WJ. Endothelin-1 regulates fate of human mesenchymal stem cells. The 60th

Annual Meeting of the Orthopaedic Research Society, March 2014, New Orleans, LA. 79) Brown PT, Slukvin I, Li WJ. Synergistic regulation of BMP7 and TGFB1 on chondrogenesis of

mesenchymal stem cells derived from embryonic stem cells. The 60th Annual Meeting of the Orthopaedic Research Society, March 2014, New Orleans, LA.

80) Tsai TL, Wang B, Squire MW, Guo LW, Li WJ. Human mesenchymal stem cell and endothelial cell

interaction through endothelin-1. The 61th Annual Meeting of the Orthopaedic Research Society, March 2015, Las Vegas, NV.

81) Palumbo SL, Tsai TL, Li WJ. Macrophage migration inhibitory factor regulates senescence of human

mesenchymal stem cells under hypoxia. The 61th Annual Meeting of the Orthopaedic Research Society, March 2015, Las Vegas, NV.

82) Tsai TL, Wang B, Squire MW, Guo LW, Li WJ. Endothelial cells produce endothelin-1 to induce osteo-

and chondro-lineage differentiation of human mesenchymal stem cells. MSC 2015 Adult Stem Cell Therapy & Regenerative Medicine, August 2015, Cleveland, OH.

83) Yuan H, Tsai TL, Zhou Y, Zhang Y, Li WJ. Role of Stiffness of Aligned Fibers in Regulation of Human

Mesenchymal Stem Cell Differentiation. The 2015 Tissue Engineering and Regenerative Medicine International Society World Congress, September 2015, Boston, MA.

84) Tsai TL, Li WJ. Soluble factors in bone marrow niche enhance human mesenchymal stem cell-based

tissue regeneration. The 62th Annual Meeting of the Orthopaedic Research Society, March 2016, Orlando, FL.

85) Zhou Y, Tsai TL, Squire MW, Li WJ. Bone marrow composition dictates lineage commitment of human

mesenchymal stem cells. The 62th Annual Meeting of the Orthopaedic Research Society, March 2016, Orlando, FL.

INVITED RESEARCH PRESENTATIONS 1) A Biodegradable, Three-dimensional Nanofibrous Scaffold for Cartilage Tissue Engineering: Fabrication,

Characterization, and Applications. Invited podium talk, The 2004 NIH NIAMS IRP Scientific Retreat, Gettysburg, PA, June 9, 2004.

Audience: conference attendees

2) Novel Cartilage Tissue Engineering using Chondrocyte-loaded Nanofibrous Composites. Invited podium talk, The 2nd International Conference “Strategies in Tissue Engineering”, Wurzburg, Germany, June 18, 2004.

Audience: conference attendees 3) Engineering Anisotropic Electrospun Biodegradable Nanofibrous Scaffolds for Musculoskeletal Tissue

Engineering. Invited podium talk, The 5th Combined Meeting of the Orthopaedic Research Societies, Banff, Alberta, Canada, October 10, 2004.

Audience: conference attendees 4) Integration between Nanofiber-based Engineered Cartilage and Native Cartilage. Invited podium talk,

The 2006 NIH NIAMS IRP Scientific Retreat, Gettysburg, PA, June 5, 2006. Audience: conference attendees 5) Biomimetic nanofibrous scaffolds for tissue engineering applications. Special research seminar,

Department of Research, Alfred I. duPont Hospital for Children, Wilmington, DE, August 2006. Audience: faculty, research staffs, graduate students 6) Nanofiber-based engineered cartilage for orthopaedic applications. Grand round seminar, Department of

Orthopaedics, Alfred I. duPont Hospital for Children, Wilmington, DE, August 2006. Audience: faculty, surgeons, research staffs, graduate students 7) Evaluation of Nanofiber-based Engineered Cartilage and its Integration with Native Cartilage. Invited

podium talk, The 25th Scientific Conference of the Society for Physical Regulation in Biology and Medicine, Honolulu, HI, January 11, 2007.

Audience: conference attendees 8) Cellular response and tissue engineering applications using biomimetic nanofibrous scaffolds.

Departmental seminar, Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, April 2007.

Audience: faculty, research staffs, graduate students 9) Nanofiber-based engineered bone and cartilage for orthopaedic applications. Grand Rounds seminar,

Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, April 2007.

Audience: faculty, surgeons, research staffs, graduate students 10) Biological Activities of Human Mesenchymal Stem Cells in Nanofibrous Matrix. Invited podium talk, The

26th Scientific Conference of the Society for Physical Regulation in Biology and Medicine, Miami, FL, January 11, 2008.

Audience: conference attendees 11) Growing tissue in the laboratory. Wednesday Nite @ The Lab series seminar, Wisconsin Alumni

Association, UW-Madison, Madison, WI, January 21, 2009. Audience: faculty, students, the general public 12) Biomimetic nanostructures as 3D culture for biomedical research and tissue engineering. Material

Science Program seminar, UW-Madison, Madison, WI, April 30, 2009. Audience: faculty, research staffs, graduate students

13) Nano-scaffolds for Tissue Engineering. Invited podium talk, The AOA North American Traveling Fellows visit, Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, October 26, 2009.

Audience: faculty, research staffs, surgeons 14) Demineralized Bone Powder Regulates Differentiation of Human Mesenchymal Stem Cells. Grand

Rounds Seminar, Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, October 28, 2009.

Audience: faculty, research staffs, surgeons 15) Nanostructured scaffold as engineered extracellular matrix for stem cell-based tissue regeneration. BME

departmental seminar, Northwestern University, Evanston, IL, November 12, 2009. Audience: faculty, research staffs, graduate students 16) Biological Regulation of Human Mesenchymal Stem cells in Three-dimensional culture. Center weekly

seminar, Stem cell & Regenerative Medicine Center, UW-Madison, Madison, WI, December 1, 2009. Audience: faculty, research staffs, graduate students 17) Nanostructured scaffold as engineered extracellular matrix for stem cell-based tissue regeneration.

Plastic Surgery grand round seminar, Department of Surgery, UW-Madison, Madison, WI, February 5, 2010.

Audience: faculty, surgeons, research staffs, graduate students 18) Musculoskeletal Tissue Regeneration. Invited speaker seminar, Student Society for Stem Cell Research,

UW-Madison, Madison, WI, April 14, 2010. Audience: undergraduate students 19) Stem Cells in Tissue Engineering. Mechanical Engineering departmental seminar, Drexel University,

Philadelphia, PA, April 26, 2010. Audience: faculty, research staffs, graduate students 20) Bioengineering Mesenchymal Stem Cell Niche. Orthopedics departmental seminar, Thomas Jefferson

University, Philadelphia, PA, April 27, 2010. Audience: faculty, research staffs, graduate students 21) Priming Pre-differentiation Human Mesenchymal Stem Cells for Chondrogenesis. BME departmental

seminar, University of Illinois at Chicago, Chicago, IL, November 12, 2010. Audience: faculty, research staffs, graduate students

22) Introduction of Electrospinning Technique. Wet tutorial for scaffold fabrication. Society for Biomaterial

2011 Annual Meeting & Exposition, Orlando, FL, April 15, 2011. Audience: conference attendees

23) Priming Pre-differentiation Human Mesenchymal Stem Cells for Chondrogenesis by Physical and

Chemical Cues. The center for biochemical and biophysical studies seminar, Northern Illinois University, Dekalb, IL, April 22, 2011.

Audience: faculty, research staffs, graduate students 24) Orthopedic Tissue Engineering. Invited talk during 3M UW campus visit. University of Wisconsin-

Madison, Madison, WI, April 26, 2011. Audience: UW faculty and 3M scientists

25) Mechanical Stimulation Provides the Key Induction Signal for Tenogenic Differentiation of Human

Mesenchymal Stem Cells in Braided Nanofibrous Scaffolds. Invited podium talk, The ASME 2011 Summer Bioengineering Conference, Farmington, PA, June 25, 2011.

Audience: conference attendees 26) Stem Cell and Nano-matrix for Musculoskeletal Tissue Engineering. Invited talk during the ESSKA ORS

Fellow visit, Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, June 28, 2011.

Audience: faculty, research staffs, physicians 27) Opportunities of Nanofibers on Tissue Engineering/biomedical Applications. Workshop on Nanofibre

Technology, University of British Columbia, Vancouver, BC, Canada, July 14, 2011. Audience: conference attendees

28) Comparison between Embryonic Stem Cell- and Adult Bone Marrow-derived Mesenchymal Stem Cells for Chondrogenesis. Invited podium talk, The 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, MA, September 3, 2011. Audience: conference attendees

29) Stem Cells for Musculoskeletal Tissue Regeneration. Invited talk in the Emerging Information and

Technology Conference (EITC), University of Chicago, Chicago, IL, July 28, 2011. Audience: conference attendees 30) Braiding Electrospun Nanofibers for Tendon/Ligament Tissue Engineering. Invited podium talk. NETInc

Innovative Nonwovens Conference, Atlanta, GA, September 14, 2011. Audience: conference attendees 31) Environmental Cues Modulate the Chondrogenic Capacity of Pre-differentiation Human Mesenchymal

Stem Cells. BME departmental seminar, Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, October 18, 2011.

Audience: faculty, research staffs, graduate students 32) Intervertebral Disc Regeneration from Co-cultured Disc and Stem Cells in Biomimetic Engineered

Extracellular Matrix Simulated by Mechanically Active Bioreactor. Young Investigator Award recipient talk, North American Spine Society 2011 Annual Meeting, Chicago, IL, November 4, 2011.

Audience: conference attendees 33) Modulating the Chondrogenic Capacity of Pre-differentiation Human Mesenchymal Stem Cells to

Enhance Cartilage Regeneration. Departmental seminar, School of Dentistry, Indiana University, Indianapolis, IN, November 18, 2011.

Audience: faculty, research staffs, graduate students 34) Mechanisms of Fibroblast Growth Factor-2 and Glucose Regulating the Chondrogenic Potential of Pre-

differentiation Human Mesenchymal Stem Cells. Invited podium talk. The 1st World Congress on Cell Science and Stem Cell Research, Philadelphia, PA, November 30, 2011.

Audience: conference attendees 35) Enhance Cartilage Regeneration by Modulating the Chondrogenic Capacity of Pre-differentiation Human

Mesenchymal Stem Cells. BME departmental seminar, Department of Biomedical Engineering, Mayo Clinic, Rochester, MN, December 9, 2011.

Audience: faculty, research staffs, graduate students 36) Osteochondral Tissue Engineering. Animal science laboratory seminar, Animal Science Laboratory,

University of Illinois at Urbana-Champaign, Urbana, IL, March 29, 2012. Audience: faculty and research staffs

37) Hyperglycemia-induced Osteoarthritis and Osteoporosis. Grand Rounds Seminar, Department of

Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, May 9, 2012. Audience: faculty, research staffs, surgeons 38) Electrospinning and Nanofiber for Biomedical Applications. Laboratory seminar, UW James Thomson

Laboratory, University of Wisconsin-Madison, Madison, WI, June 12, 2012. Audience: faculty, research staffs, graduate students 39) Biomimetic Nanofiber as Artificial Extracellular Matrix for Stem Cell-based Tissue Regeneration. The 3rd

International Conference of the Matrix Biology Working Group of the Korean Society for Biochemistry and Molecular Biology, Yonsei University, Seoul, Republic of Korea, November 23, 2012.

Audience: faculty, research staffs, graduate students 40) Promise of Stem Cell Research for Orthopedic Regenerative Medicine. The Meriter Medical Staff

Conference, Meriter Hospital, Madison, WI, February 22, 2013. Audience: retired surgeons and physicians 41) Stem Cell-based Tendon/Ligament Tissue Engineering. Grand Rounds Seminar, Department of

Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, April 24, 2013. Audience: faculty, research staffs, surgeons 42) Nanofiber as Artificial Extracellular Matrix fro Stem Cell-based Tissue Regeneration. Invited 3M

Innovation Talk, The 3M Company, Saint Paul, MN, June 12, 2013. Audience: researchers and engineers 43) Stem Cell and Nanofiber for Musculoskeletal Tissue Regeneration. Departmental seminar, Department of

Orthopedic Surgery, Rush University Medical Center, Chicago, IL, June 19, 2013. Audience: faculty, research staffs, graduate students 44) Stem Cells for Musculoskeletal Tissue Regeneration. Invited talk, Wisconsin Stem Cell Roundtable,

University of Wisconsin-Madison, Madison, WI, August 8, 2013. Audience: undergraduate and graduate students 45) Osteogenesis of Human Mesenchymal Stem Cells Enhanced by Osteoprotegerin through Activation of

Nuclear Factor-kappa B. Invited podium talk, Tissue Engineering and Regenerative Medicine International Society Americas Annual Conference 2013, Atlanta, GA, November 12, 2013.

Audience: conference attendees 46) Stem Cell Differentiation in Braided Nanofibrous Scaffolds for Tendon/Ligament Tissue Engineering.

Invited podium talk, The 2013 MRS Fall Meeting, Boston, MA, December 4, 2013. Audience: conference attendees 47) Stem Cell and Nanofiber for Musculoskeletal Tissue Regeneration. Departmental seminar, Department of

Exercise Physiology, West Virginia University, Morgantown, WV, December 12, 2013. Audience: faculty, research staffs, graduate students

48) Macrophage Migration Inhibitory Factor Regulates AKT Signaling in Hypoxic Culture to Modulate

Senescence of Human Mesenchymal Stem Cells. SCRMC seminar. Stem Cell & Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI, January 28, 2014.

Audience: faculty, research staffs, graduate students 49) Stem Cell-based Regenerative Medicine. Institutional seminar, Graduate Institute of Biomedical Materials

& Tissue Engineering, Taipei Medical University, Taipei, Taiwan, March 19, 2014. Audience: faculty, research staffs, graduate students 50) Stem Cell-based Regenerative Medicine. BME institutional seminar, Graduate Institute of Biomedical

Engineering, National Central University, Taoyuan, Taiwan, March 25, 2014. Audience: faculty, research staffs, graduate students 51) Nanostructural Biomaterials for Tissue Engineering and Biomedical Applications. BME departmental

seminar, Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, Taiwan, March 26, 2014.

Audience: faculty, research staffs, graduate students 52) Stem Cell-based Regenerative Medicine. Graduate Institute of Clinical Medical Sciences institutional

seminar, Chang Gung University, Kaohsiung, Taiwan, March 27, 2014. Audience: faculty, research staffs, graduate students, physicians 53) Role of Osteoprotegerin in Regulation of Osteogenesis of Human Mesenchymal Stem Cells for Bone

Tissue Engineering. BME departmental seminar, Department of Biomedical Engineering, Pennsylvania State University, University Park, April 16, 2014.

Audience: faculty, research staffs, graduate students 54) Intervertebral Disc Regeneration using Nanofibers and Mesenchymal Stem Cells. Invited talk during the

ASEAN ORS Fellow visit, Department of Orthopedics and Rehabilitation, University of Wisconsin-Madison, Madison, WI, June 9, 2014.

Audience: faculty, research staffs, surgeons 55) Role of Osteoprotegerin in Regulation of Osteogenesis of Human Mesenchymal Stem Cells for Bone

Tissue Engineering. Institutional seminar, Institute for Regenerative Engineering, University of Connecticut, Farmington, CT, June 27, 2014.

Audience: faculty, research staffs, graduate students 56) Biomimetic Nanofibrous Structure Directs Stem Cell Differentiation for Coonective Tissue Generation.

BME departmental seminar, Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, September 8, 2014.

Audience: faculty, research staffs, graduate students 57) Co-cultured Disc and Stem Cells in Biomimetic Engineered Scaffold Stimulated by Mechanical Loading

for Intervertebral Disc Generation. Invited podium talk, Tissue Engineering and Regenerative Medicine International Society Asia-Pacific Annual Conference 2014, Daegu, Korea, September 27, 2014.

Audience: conference attendees 58) Stem Cell-based Regenerative Medicine. Institutional seminar, Orthopedic Institute, Soochow University,

Suzhou, China, September 29, 2014. Audience: faculty, research staffs, graduate students, surgeons

59) Stem Cell-based Regenerative Medicine. Special seminar, Department of Orthopedic Surgery, Zhongda

Hospital Southeast University, Nanjing, China, September 30, 2014. Audience: faculty, research staffs, graduate students, surgeons 60) Stem Cell-based Regenerative Medicine. Institutional seminar, Institute of Biomedical Engineering and

Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, October 3, 2014. Audience: faculty, research staffs, graduate students 61) Role of Osteoprotegerin in Regulation of Osteogenesis of Human Mesenchymal Stem Cells for Bone

Tissue Engineering. Institutional seminar. Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan, October 6, 2014.

Audience: faculty, research staffs, graduate students 62) Stem Cell-based Musculoskeletal Tissue Regeneration. BME departmental seminar, Department of

Biomedical Engineering, Michigan Technological University, Houghton, MI, October 17, 2014. Audience: faculty, research staffs, graduate students 63) Biomimetic Engineered Structures Directs Stem Cell Differentiation for Connective Tissue Generation.

Invited talk. Laboratory seminar, UW BioInspired Materials Laboratory, University of Wisconsin-Madison, Madison, WI, October 18, 2014.

Audience: faculty, research staffs, graduate students 64) Emerging Opportunities of Nanofiber technology for Regenerative Medicine Applications. Invited Keynote

Speech, The Fiber Society Fall 2014 Conference, Philadelphia, PA, October 22, 2014. Audience: conference attendees 65) Priming Mesenchymal Stem Cells for Enhanced Multilineage Differentiation. Departmental seminar,

Department of Surgery, University of Wisconsin-Madison, Madison, WI, December 5, 2014. Audience: faculty, research staffs, graduate students, surgeons 66) Priming Human Mesenchymal Stem Cells for Enhanced Lineage-specific Differentiation. Invited podium

talk, The 2015 Fusion Conference on Musculoskeletal Development and Regeneration, Cancun, Mexico, February 8, 2015.

Audience: conference attendees 67) Dual Roles of Osteoprotegerin in Bone Remodeling. Grand Rounds Seminar, Department of Orthopedics

and Rehabilitation, University of Wisconsin-Madison, Madison, WI, February 25, 2015. Audience: faculty, research staffs, surgeons 68) Priming Mesenchymal Stem Cells for Musculoskeletal Tissue Engineering. BME departmental seminar.

The Fischell Department of Bioengineering, University of Maryland, College Park, MD, March 13, 2015. Audience: faculty, research staffs, graduate students 69) Macrophage Migration Inhibitory Factor Regulates Senescence of Human Mesenchymal Stem Cells

under Hypoxia. Invited podium talk, The 61th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, March 29, 2015.

Audience: conference attendees 70) Chondrogenic Differentiation of Stem Cells Regulated by a Network of Signaling Pathways. Invited

podium talk, The 10th Annual Wisconsin Stem Cell Symposium, Fitchburg, WI, April 22, 2015.

Audience: conference attendees 71) Biomimetic Engineered Structures Directs Stem Cell Differentiation for Connective Tissue Generation.

Invited talk during the 3M UW campus visit. University of Wisconsin-Madison, Madison, WI, May 4, 2015. Audience: UW faculty and 3M scientists 72) Endothelial Cells Direct Human Mesenchymal Stem Cells for Osteo- and Chondro-lineage Differentiation.

Invited podium talk, The 2015 Regenerative Medicine Workshop at Hilton Head, Hilton Head, SC, May 15, 2015.

Audience: conference attendees 73) Strategies to Improve Stem Cell Differentiation for Skeletal Tissue Generation. Institutional seminar,

Institute of Regenerative Medicine, LifeNet Health, Virginia Beach, VA, June 11, 2015. Audience: scientists, technicians, staffs

74) Strategies to Enhance Stem Cell Differentiation for Skeletal Tissue Generation. Invited talk at the

SCRMC Fall Conference, University of Wisconsin-Madison, Madison, WI, September 25, 2015. Audience: Faculty, research staffs, graduate students, technicians

75) Biomaterials in Bone/Tendon/Cartilage Engineering. Invited talk at the Society for Biomaterials 2015 Biomaterials Day, University of Wisconsin-Madison, Madison, WI, November 13, 2015. Audience: Faculty, research staffs, graduate students, technicians

PATENTS Li, Wan-Ju and Tuan, Rocky. Tissue Engineered Cartilage, Method of Making Same, Therapeutic and Cosmetic Surgical Application Using Same. U.S. Patent 8,202,551, filed June 15, 2006, and issued June 19, 2012. EDUCATIONAL ACTIVITIES & PRESENTATIONS Classroom Teaching BME 2009/Fall

1. BME 200/300: Biomedical Engineering Design BME 2010/Fall

1. BME 400: Capstone Design Course in Biomedical Engineering 2. BME 510: Introduction to Tissue Engineering (1 lecture)

BME 2011/Spring

1. BME 402: Biomedical Engineering Design 2. BME 601: Nanomaterials for Biomedical Applications (3 lectures)

BME 2011/Fall

1. BME 510: Introduction to Tissue Engineering (1 lecture) BME 2012/Spring

1. BME 545: Engineering Extracellular Matrices (1 lecture) 2. BME 601: Nanomaterials for Biomedical Applications (3 lectures)

BME 2012/Fall

1. BME 200/300: Biomedical Engineering Design 2. BME 517: Biology in Engineering Seminar (1 lecture)

BME 2013/Spring

1. BME 545: Engineering Extracellular Matrices (1 lecture) 2. BME 601: Nanomaterials for Biomedical Applications (3 lectures) 3. CRB 640: Fundamentals of Stem Cell and Regenerative Biology (5 lectures)

BME 2014/Spring

1. CRB 640: Fundamentals of Stem Cell and Regenerative Biology (5 lectures) BME 2015/Spring

1. BME 430: Biological Interactions with Materials (1 lecture) 2. CRB 640: Fundamentals of Stem Cell and Regenerative Biology (5 lectures)

BME 2015/Fall

1. BME 510: Introduction to Tissue Engineering

Mentoring BME 2008/Fall

1. BME 399: Independent Study 2. BME 790: Master’s Research & Thesis

BME 2009/Spring

1. BME 399: Independent Study 2. BME 790: Master’s Research & Thesis

BME 2009/Summer

1. BME 790: Master’s Research & Thesis BME 2009/Fall

1. BME 399: Independent Study 2. BME 790: Master’s Research & Thesis 3. BME 890: Pre-dissertation Research

BME 2010/Spring

1. BME 399: Independent Study 2. BME 699: Advanced Independent Study 3. BME 790: Master’s Research & Thesis 4. BME 890: Pre-dissertation Research

BME 2010/Summer

1. BME 399: Independent Study 2. BME 790: Master’s Research & Thesis 3. BME 890: Pre-dissertation Research

BME 2010/Fall

1. BME 399: Independent Study

2. BME 699: Advanced Independent Study 3. BME 790: Master’s Research & Thesis 4. BME 890: Pre-dissertation Research

BME 2011/Spring

1. BME 399: Independent Study 2. BME 699: Advanced Independent Study 3. BME 790: Master’s Research & Thesis 4. BME 890: Pre-dissertation Research

BME 2011/Summer

1. BME 699: Advanced Independent Study 2. BME 890: Pre-dissertation Research

BME 2011/Fall

1. BME 399: Independent Study 2. BME 699: Advanced Independent Study 3. BME 890: Pre-dissertation Research 4. BME 990: Research and Thesis

BME 2012/Spring

1. BME 399: Independent Study 2. BME 699: Advanced Independent Study 3. BME 890: Pre-dissertation Research 4. BME 990: Research and Thesis

BME 2012/Summer

1. BME 699: Advanced Independent Study 2. BME 890: Pre-dissertation Research 3. BME 990: Research and Thesis

BME 2012/Fall

1. BME 399: Independent Study 2. BME 699: Advanced Independent Study 3. BME 890: Pre-dissertation Research 4. BME 990: Research and Thesis

BME 2013/Spring

1. BME 399: Independent Study 2. BME 699: Advanced Independent Study 3. BME 890: Pre-dissertation Research 4. BME 990: Research and Thesis

BME 2013/Summer

1. BME 890: Pre-dissertation Research 2. BME 990: Research and Thesis

BME 2013/Fall

1. BME 399: Independent Study 2. BME 790: Master’s Research & Thesis 3. BME 890: Pre-dissertation Research

4. BME 990: Research and Thesis BME 2014/Spring

1. BME 399: Independent Study 2. BME 890: Pre-dissertation Research 3. BME 990: Research and Thesis

BME 2014/Summer

1. BME 890: Pre-dissertation Research 2. BME 990: Research and Thesis

BME 2014/Fall

1. BME 399: Independent Study 2. BME 790: Master’s Research & Thesis 3. BME 990: Research and Thesis

BME 2015/Spring

1. BME 399: Independent Study 2. BME 990: Research and Thesis

BME 2015/Summer

1. BME 399: Independent Study 2. BME 990: Research and Thesis

BME 2015/Fall

1. BME 399: Independent Study 2. BME 790: Master’s Research & Thesis

SERVICE ACTIVITIES University Service Department of Orthopedics and Rehabilitation

2009-present Resident Interview Committee 2011-present Orthopedics Research Foundation Scientific Advisory Committee

Department of Biomedical Engineering

2008-present Graduate Student Recruitment Committee 2008-present Qualifying Examination Committee 2008-present Ph.D. Student Research and Thesis Committee 2014-present Scholarship Committee

Material Science Program

2008-present Ph.D. Student Research and Thesis Committee Cellular and Molecular Biology Program

2013 Graduate Student Recruitment Committee Stem Cell & Regenerative Medicine Center (SCRMC)

2009 Scientific Retreat Organizing Committee 2013 Poster Presentation Awards Committee

2015 Wisconsin Stem Cell Symposium Organizing Committee School of Medicine and Public Health

2009-present M.D./Ph.D. Student Interview for Medical Scientist Training Program Professional Service - National Research grant review panel

1. Institution: Department of Defense Grant type: Development Related Medical Research Program (DRMRP) Date: February 2009

2. Institution: North Carolina Biotechnology Center Grant type: 2010 Collaborative Funding Grant Date: April 2010

3. Institution: New York Stem Cell Program Grant type: Investigator Initiated Research Projects and Innovative, Development of Exploratory Activities Date: February 2012

4. Institution: UW Institute for Clinical and Translational Research Grant type: Pilot Award Program Date: May 2012

5. Institution: Department of Veterans Affairs Grant type: Rehabilitation Research and Development Date: August 2012

6. Institution: Department of Veterans Affairs Grant type: Rehabilitation Research and Development Date: February 2013

7. Institution: Department of Veterans Affairs Grant type: Rehabilitation Research and Development Date: August 2013

8. Institution: Indo-US Science & Technology Forum through AAAS Grant type: Joint Center on Orthopaedic Regeneration Date: January 2015

9. Institution: UW Institute for Clinical and Translational Research Grant type: Pilot Award Program Date: March 2015

Conference abstract review panel

1. Conference: The 56th Annual Meeting of the Orthopaedic Research Society Role: Review and rate submitted abstracts for the Session of Biomaterials

2. Conference: The Society for Biomaterials 2010 Annual Meeting Role: Review and rate submitted abstracts for the Session of Stem Cell-Biomaterial Interactions

3. Conference: The 57th Annual Meeting of the Orthopaedic Research Society Role: Review and rate submitted abstracts for the Session of Biomaterials-Bioactive

4. Conference: The Society for Biomaterials 2011 Annual Meeting Role: Review and rate submitted abstracts for the Session of Stem Cell-Biomaterial Interactions

5. Conference: The 58th Annual Meeting of the Orthopaedic Research Society Role: Review and rate submitted abstracts for the Session of Biomaterials-Bioactive

6. Conference: The 59th Annual Meeting of the Orthopaedic Research Society Role: Review and rate submitted abstracts for the Session of Biomaterials-Bioactive

7. Conference: The 8th Annual Wisconsin Stem Cell Symposium Role: Review and rate submitted abstracts for the symposium

8. Conference: The 10th Annual Wisconsin Stem Cell Symposium Role: Review and rate submitted abstracts for the symposium

9. Conference: The 2015 Regenerative Medicine Workshop at Hilton Head Role: Review and rate submitted abstracts for the conference

10. Conference: The BMES 2015 Annual Meeting Role: Review and rate submitted abstracts for the meeting

Conference organizer, or topic and session chair

1. Conference: Stem Cell & Regenerative Medicine Center (SCRMC) Retreat Role: Session chair, Skeletal and wound repair session Date: 9/17/2009 Location: Madison, WI

2. Conference: ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology Role: Session chair, Session 4-3 Nanobiomaterials as engineered extracellular matrix for stem cell-based tissue regeneration Date: 2/7/2010-2/10/2010 Location: Houston, TX

3. Conference: The 56th Annual Meeting of the Orthopaedic Research Society Role: Session chair, Session 05 – Biomaterial Date: 3/6/2010-3/9/2010 Location: New Orleans, LA

4. Conference: The 57th Annual Meeting of the Orthopaedic Research Society Role: Session chair, Session – Biomaterial Date: 1/13/2011-1/16/2011 Location: Long Beach, CA

5. Conference: The 1st World Congress on Cell Science and Stem Cell Research

Role: Session chair, Track 4-1: Cartilage Tissue Engineering & Track 4-3: Tissue Engineering and Regenerative Medicine Date: 11/29/2011-12/1/2011 Location: Philadelphia, PA

6. Conference: The 10th Annual Wisconsin Stem Cell Symposium Role: Conference organizer Date: 4/22/2015 Location: Fitchburg, WI

7. Conference: The 2015 Regenerative Medicine Workshop at Hilton Head Role: Conference organizing committee member Date: 5/13/2015-5/16/2015 Location: Hilton Head, SC

8. Conference: The 2015 Regenerative Medicine Workshop at Hilton Head Role: Session chair, Session VI – Controlling Stem Cell Fate Date: 5/13/2015-5/16/2015 Location: Hilton Head, SC

9. Conference: The 2016 Regenerative Medicine Workshop at Hilton Head Role: Conference organizing committee member Date: 3/16/2016-3/19/2016 Location: Hilton Head, SC

Professional Service - International Research grant review panel

1. Institution: The Netherlands Organization for Health Research and Development (ZonMw) Grant type: Equipment Programme Grant Date: October 2009

2. Institution: US-Israel Binational Science Foundation Grant type: Biomedical Engineering: Tissue Engineering, Stem Cells and Biotechnology Date: March 2010

3. Institution: AO Foundation Grant type: AO Research Grant Date: July 2010

4. Institution: Ontario Ministry of Research and Innovation Grant type: Ontario Research Fund - Research Excellent Program Date: February 2011

5. Institution: AO Foundation Grant type: AO Research Grant Date: January 2012

6. Institution: National Nature Science Foundation of China Grant type: Division of Biochemistry & Molecular Biology and Tissue Engineering

Date: April 2015 Conference organizer, or topic and session chair

1. Conference: Tissue Engineering and Regenerative Medicine International Society Asia-Pacific Annual Conference 2014 Role: Session chair, Session – Intervertebral Disc Regeneration Date: 9/24/2014-9/27/2014 Location: Daegu, Korea

Journal Editorial Boards 2009-present Editorial board member, Formosan Journal of Musculoskeletal Disorders 2010-present Editorial board member, Journal of Biosensors and Bioelectronics 2011-present Editorial board member, American Journal of Stem Cells 2011-present Editorial board member, Journal of Regenerative Medicine and Tissue Engineering 2011-present Academic editor, PLoS One 2012-present Editorial board member, Journal of Regenerative Medicine 2012-2014 Editor-in Chief, Nanomaterials and Tissue Regeneration 2013-present Editorial board member, BioMed Research International 2015-present Editorial board member, Regenerative Engineering and Translational Medicine Journal Editorial Reviews 2005-present Tissue Engineering 2005-present Journal of Biomedical Materials Research Part A 2006-present Biotechnology Journal 2007-present Acta Biomaterialia 2007-present Biomacromolecules 2008-present Stem Cells and Development 2008-present Biofabrication 2008-present ASAIO Journal 2009-present Biomedical Materials 2010-present Cytotherapy 2010-present Expert Opinion on Biological Therapy 2010-present Journal of Biomaterials Science: Polymer Edition 2010-present Polymers for Advanced Technologies 2010-present Journal of Materials Science 2010-present Integrative Biology 2010-present Journal of Biomedical Materials Research Part B – Applied Biomaterials 2011-present Nanomedicine: Nanotechnology, Biology, and Medicine 2011-present Molecular Pharmaceutics 2011-present Clinical Orthopaedics and Related Research 2011-present Stem Cells 2011-present Journal of Orthopaedic Research 2011-present IEEE Transaction on Nanobioscience 2012-present Biomaterials 2012-present Biotechnology Progress 2012-present BMC Biotechnology 2012-present Stem Cell Research and Therapy 2012-present Science Translational Medicine

2012-present Journal of Medical and Biological Engineering 2013-present PLoS One 2013-present Journal of Regenerative Medicine and Tissue Engineering 2013-present Drug Delivery and Translational Research 2013-present Journal of Biomaterials and Tissue Engineering 2013-present Nature Communications 2013-present Cellular ad Molecular Bioengineering 2014-present Cell and Tissue Research 2014-presnet Stem Cell Reviews and Reports 2014-present Molecular Pharmaceutics 2015-present Scientific Reports OTHER ACTIVITIES Outreach Activities February 2013 Seminar on the topic of “Promise of Stem Cell Research for Orthopedic Regenerative

Medicine” in the Meriter Medical Staff Conference at the Meriter Hospital, Madison, WI.