ELSEVIER Toxicology 119 (1997) 249-250

Volume contents

Volume 119 (1997)

Special Issue

FOURTH SUMMER SCHOOL IN IMMUNOTOXICOLOGY

October 18-20, 1995

Autoimmunity caused by xenobiotics P.E.Bigazzi(USA)....................................................

Drug-induced autoimmuity: experience of the French Pharmacovigilance system T. Vial, B. Nicolas, J. Descotes (France). . . . . . . . . . . . . . . . . . . . , . . . . . . . . . . .

Animal models in autoimmune disease in immunotoxicity assessment J.-C. Farine (Switzerland) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Current trends in drug-induced autoimmunity J.P. Uetrecht (Canada) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

The popliteal lymph node assay in 1996 J. Descotes, C. Patriarca, T. Vial, F. Verdier (France). . . . . . . . . . . . . . . . . . . .

Autoantibodies in conventional toxicity testing F. Verdier, C. Patriarca, J. Descotes (France). . . . . . . . . . . . . . . . . . .

Risk assessment for the harmful effects of immunotoxic agents on the immunological resistance to infectious diseases: ultraviolet light as an example H. Van Loveren, W. Goettsch, W. Slob, J. Garssen (The Netherlands) . . . . . . . . . . . .

Mutant and transgenic mice in immunotoxicology: an introduction M. Lovik (Norway). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Epitope mapping: a new method for biological evaluation and immunotoxicology J.-M.R. Saint-Rem) (Belgium). . . . . . . . . . . . . . . . . . . . . , . . . . . . . . .

Immunohistochemistry for light microscopy in safety evaluation of therapeutic agents: an overview R. Burnett, Y. Guichard, E. Barale (France) . . . . . . . . . . . . . . . . . . . . . . . . .

Issues with introducing new immunotoxicology methods into the safety assessment of pharmaceuticals J.H. Dean (USA) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

l-21

23-27

29-35

37-43

45-49

51-58

59-64

65-76

77-81

83-93

95-101

Skeletal changes in multiparous, nulliparous and ovariectomized mice fed either a nutrient-sufficient or -deficient An attempt to develaop au animal model of hi-Itai disease

B.D. Whelton, D.P. Peterson, E.S. Moretti, H. Dare, M.H. Bhattacharyya (USA) . . . . . . . . Kidney changes in multiparous, nulliparous and ovariectomized mice fed either a nutrient-sufficient or -deficient

diet containing cadmium Renal dysfunction a’pparently was not severe enough to produce full Itai-Itai disease B.D. Whelton, D.P. Peterson, ES. Moretti, R.W. Mauser, M.H. Bhattacharyya (USA) . . . . . . . . .

103-121

123-140

250 Volume contents / Toxicology 119 (1997) 249-250

Hepatic levels of cadmium, zinc and copper in multiparous, nulliparous and ovariectomized mice fed either a nutrient-sufficient or -deficient diet containing cadmium With chronic exposure, translocation of Cd from kidney to liver occurs B.D. Whelton, D.P. Peterson, ES. Moretti, R.W. Mauser, M.H. Bhattacharyya (USA) 141-153

Lead may affect glucocorticoid signal transduction in cultured hepatoma cells through inhibition of protein kinase C An interaction of lead with calcium-mediated cellular processes is demonstrated L.E. Tonner, A.S. Heiman (USA). . . . . .

In vitro paraoxon (E 600) exposure: no activating effect on human blood coagulation There is no effect on fibrin monomer concentration in vitro G. Petroianu, M. Toomes, W. Maleck, W. Bergler, R. Riifer (Germany). . .

155-166

167-173

Announcement. . . . . 175

Editorial note K.J.Netter.........................................................

Effect of thiols on cadmium-induced expression of metallothionein and other oxidant stress genes in rat lung epithelial cells A study on redox regulation

177

Q. Gong, B.A. Hart (USA) . . . . . . . . . . . . 179-191 Effect of ethanol pretreatment on mercury distribution in organs of fetal guinea pigs following in utero exposure

to mercury vapor Fetal hepatic mettiothionein protects against Hg crossing the placenta and may regulate Hg distribution in the

fetus M. Yoshida, H. Satoh, Y. Sumi (Japan). . . . . . . . . .

Immunotoxicological effects of benzene inhalation in male Sprague-Dawley rats No changes in thymus and spleen weight, B and T lymphocyte counts and humoral immunity were observed in rats

exposed up to 200 ppm benzene for 6 hours/day, 5 days/week for 4 weeks S.N. Robinson, R. Shah, B.A. Wong, V.A. Wong, G.M. Farris (USA) . . . . .

Antimony-induced alterations in thiol homeostasis and adenine nucleotide status in cultured cardiac myocytes ATP loss may be a secondary event to the other cellular changes induced by antimony M.A. Tirmenstein, P.I. Mathias, J.E. Snawder, H.E. Wey, M. Toraason (USA) .

Computational predictive programs (expert systems) in toxicology Systems of electronic prediction of toxicity from chemical structures are compared E. Benfenati, G. Gini (Italy). . . . . .

193-201

203-213

215-223

225-237

Corrigendum .......................................................... 239 Announcement. ........................................................ 241 AuthorIndex .......................................................... 243 Subject Index .......................................................... 245-247 Volume Contents ....................................................... 249-250