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Nathan Lighthizer, O.D., F.A.A.O.Assistant Dean, Clinical Care Services

Director of Continuing EducationChief of Specialty Care Clinics

Chief of Electrodiagnostics ClinicOklahoma College of Optometry

lighthiz@nsuok.edu

¨ Nearly 1 million Americans develop shingles each year

¨ Ocular involvement accounts for up to 25% of presenting cases

¨ Over 50% incur long term ocular damage

***Varicella-Zoster Virus***¨ Herpes DNA virus that causes 2 distinct

syndromes1. Primary infection – Chicken pox (Varicella)

ú Usually in childrenú Highly contagious***ú Very itchy maculopapular rash with vesicles that crust

over after ≈ 5 daysú 96% of people develop by 20 years of ageú Vaccine now available

***Varicella-Zoster Virus***¨ Herpes DNA virus that causes 2 distinct

syndromes1. Primary infection – Chicken pox (Varicella)

ú Usually in childrenú Highly contagious***ú Very itchy maculopapular rash with vesicles that crust

over after ≈ 5 daysú 96% of people develop by 20 years of ageú Vaccine now available

¨ Herpes DNA virus that causes 2 distinct syndromes2. Reactivation – Shingles (Herpes Zoster)ú More often in the elderly and immunosuppressed

(AIDS)­ Systemic work-up if Zoster in someone < 40

ú Can get shingles anywhere on the bodyú Herpes Zoster Ophthalmicus (HZO)­ Shingles involving the dermatome supplied by the

ophthalmic division of the CNV (trigeminal)  15% of zoster cases

¨ Symptoms:¡ Generalized malaise, tiredness, fever¡ Headache, tenderness, paresthesias (tingling), and

pain on one side of the scalp***ú Will often precede rash

¡ Rash on one side of the forehead¡ Red eye¡ Eye pain & light sensitivity

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¨ Signs:¡ Maculopapular rash -> vesicles ->

pustules -> crusting on the forehead

¡ Respects the midline***¡ Hutchinson sign

ú rash on the tip or side of the nose***

¡ Classically does not involve the lower lid

¡ Numerous other ocular signs

¨ Other Eye Disease (Acute):¡ Acute epithelial keratitis (pseudodendrites)¡ Conjunctivitis¡ Stromal (interstitial) interstitial keratitis¡ Endotheliitis (disciform keratitis)¡ Neurotrophic keratitis

¨ Other Eye Disease (Acute):¡ Episcleritis¡ Scleritis¡ Anterior uveitis¡ IOP elevation¡ Retinitis¡ Choroiditis¡ Neurological complications (nerve palsies)¡ Vascular occlusion

¡ Treat the complications just like as if they were primary conditions

¨ Other Eye Disease (Chronic):¡ Neurotrophic keratitis – 50%¡ Scleritis¡ Mucous plaque keratitis – 5%¡ Eyelid scarring

A. Acyclovir400mg5x/dayB. Acyclovir800mg5x/dayC. Valtrex500mg3x/dayD. Valtrex1000mg3x/dayE. Famvir 250mg3x/dayF. Famvir 500mg3x/dayG. Zirgan 5x/day

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¨ Treatment:¡ Treat the complications just like as if they were

primary conditions¡ Oral antivirals – must be started within 72 hours of

symptoms**ú Acyclovir 800mg 5x/day x 7-10 daysú Valtrex 1000mg 3x/day X 7-10 daysú Famciclovir 500mg 3x/day X 7-10 days

¡ Topical ointment to skin lesions to help prevent scarringú Bacitracin, erythromycin

¨ Prevention:¡ Zostivax vaccine

ú Live attenuated herpes virusú Only given to people who know they had chicken pox

as a child***ú Only studied in patients > 60 yo

­ 51% reduction in incidence of HZ­ 60% reduction in symptom severity in those who got HZ­ 66.5% reduction in post-herpetic neuralgia

¨ Post-herpetic Neuralgia¡ Constant or intermittent pain that persists for more

than one month after the rash has healed¡ Older patients with early severe pain and larger area

are at greater risk¡ Can be so severe that it leads to depression & suicide¡ Improves with time

ú Only 2% of pts affected 5 years out¡ Tx:

ú Cool compressesú Topical capsaicin ointment or lidocaine creamú Analgesics (Tylenol 3, Vicoden)ú Amitriptyline 25mg PO TIDú Neurotin (Gabapentin)

¨ Signs:¡ Red eye (conj hyperemia)¡ Watery discharge¡ Follicles in the inferior fornix

& conj¡ (+) PA node***

¡ Red/swollen eyelids¡ Petechial sub-conj hemes¡ SPK¡ SEI’s (sub-epithelial infiltrates)¡ Pseudomembranes/membranes

often seen in EKC

¨ Timecourse ¨ Signs:¡ Red eye (conj hyperemia)¡ Watery discharge¡ Follicles in the inferior fornix

& conj¡ (+) PA node***

¡ Red/swollen eyelids¡ Petechial sub-conj hemes¡ SPK¡ SEI’s (sub-epithelial infiltrates)¡ Pseudomembranes/membranes

often seen in EKC

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¨ Diagnosis¡ Based on clinical symptoms

¨ Treatment:¡ Cool compresses¡ Artificial tears¡ “get the red out drops”

ú Vasoconstrictors such as Visine¡ Hygiene***¡ Quarantine/Isolation

¡ Betadine 5% solution???¡ Zirgan???¡ Lotemax/Pred Forte QID??? – not until late

¨ Diagnosis¡ Based on clinical symptoms

¨ Treatment:¡ Cool compresses¡ Artificial tears¡ “get the red out drops”

ú Vasoconstrictors such as Visine¡ Hygiene***¡ Quarantine/Isolation

¡ Betadine 5% solution???¡ Zirgan???¡ Lotemax/Pred Forte QID??? – not until late

¨ Most common virus found in humans¡ 60-99% are infected by 20 years old

¨ Double stranded DNA virus¡ HSV type 1 (HSV-1)¡ HSV type 2 (HSV-2)

¨ Primary infection¡ Occurs in childhood via droplet exposure¡ Subclinical infection in most

¨ Secondary infection (recurrence)

¨ Recurrent infection:¡ After primary infection the virus is carried to the sensory

ganglion for that dermatome (trigeminal ganglion) where a latent infection is established.

¡ Latent virus is incorporated in host DNA and cannot be eradicated

¡ Stressors (trauma, UV light, fever, hormonal changes, finals week, etc) cause reactivation of the virus and it is transported in the sensory axons to the periphery -> clinical signs/symptoms

¡ Ocular recurrence -> 10% at one year, 50% at ten years

¨ Epithelial Keratitis:¡ Symptoms:

ú Ocular irritation, redness, photophobia, watering, blurred vision

¡ Signs:ú Swollen opaque epithelial cells arranged in a course

punctate or stellate patternú Central desquamation results in a dendrite***

1. Central ulceration2. Terminal end bulbs

ú ***Corneal sensation is reduced***

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¨ Epithelial Keratitis:¡ Symptoms:

ú Ocular irritation, redness, photophobia, watering, blurred vision

¡ Signs:ú Swollen opaque epithelial cells arranged in a course

punctate or stellate patternú Central desquamation results in a dendrite***

1. Central ulceration2. Terminal end bulbs

ú ***Corneal sensation is reduced***

¨ Epithelial Keratitis:¡ Signs (con’t):

ú Mild associated subepithelial hazeú Elevated IOP***ú Persistant SPK and irregular epithelium as the ulcer is

healing

¡ Differential diagnosis:ú Herpes zosterú Healing corneal abrasionú Acanthamoeba keratitisú Medicamentosa

¨ Epithelial Keratitis:¡ Treatment:

ú Zirgan (ganciclovir gel 0.15%)­ 5x/day until the dendrite disappears­ 3x/day for another week

ú Viroptic (trifluridine solution 1%)­ 9x/day until the dendrite disappears­ 5x/day for another week

ú Oral antivirals (if topical not well tolerated):­ Acyclovir 400 mg 5x/day X 7-10 days­ Valtrex 500 mg 3x/day X 7-10 days­ Famvir 250 mg 3x/day X 7-10 days

¨ Epithelial Keratitis:¡ Treatment (con’t):

ú Debridement of the dendritic ulcer???ú Oral antivirals???ú IOP control

­ Avoid prostaglandins???ú Steroids???

¡ Follow-upú Day 1, 4, 7

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¨ Marginal keratitis:¡ Very rare

¡ Looks like a marginal infiltrate....but

¡ In HSV marginal keratitis:1. Much more pain2. Deep neovascularization3. No clear zone between

infiltrate and limbus

¨ Immune Stromal Keratitis (ISK):¡ 2% of initial ocular HSV presentations¡ 20-61% of recurrent disease

¡ 88% non-necrotizing¡ 7% necrotizing

¡ ***Can be visually devastating***

¨ Immune Stromal Keratitis:¡ Symptoms:

ú Gradual blurred visionú Halosú Discomfort/Pain ú Redness

¨ Immune Stromal Keratitis:¡ Signs (non-necrotizing):

ú Stromal haze (inflammation & edema)ú Neovascularization (deep)ú Immune ringú Scarring and/or thinningú Intact epithelium***

¡ Signs (necrotizing):ú All of the aboveú More dense infiltrationú Often w/ overlying epithelial defectú Necrosis and/or ulcerationú ***high perforation risk***

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A. OralantiviralsB. TopicalantiviralsC. Topicalsteroidswith

prophylacticantiviralcover

D. Debridement

¨ Immune Stromal Keratitis:¡ Treatment:

ú Topical steroids­ Pred Forte QID-q2H­ Durezol BID-QID­ Lotemax QID

ú Topical anti-viral cover­ Viroptic (trifluridine 1%) QID­ Zirgan (ganciclovir 0.15%) QID

ú Topical cyclosporin (Restasis), AT’s, ung’s to facilitate epithelial healing if ulceration is present

¨ Endotheliitis: AKA Disciform Keratitis¡ Not considered a primary form of stromal keratitis

ú Stromal edema is present secondary to endothelial inflammation

¡ Symptoms:ú Blurred visionú Halosú Discomfort/Painú Redness

¨ Endotheliitis: AKA Disciform Keratitis¡ Signs:

ú Central zone of stromal edema often with overlying epithelial edema

ú KP’s underlying the edemaú AC reactionú IOP may be elevatedú Reduced corneal sensationú Healed lesions often have a faint ring of stromal or

subepithelial opacification and thinning

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¨ Endotheliitis: AKA Disciform Keratitis¡ Treatment:

ú Topical steroids­ Pred Forte QID-q2H­ Durezol BID-QID­ Lotemax QID

ú Topical anti-viral cover­ Viroptic (trifluridine 1%) QID­ Zirgan (ganciclovir 0.15%) TID

ú Topical cyclosporin (Restasis), AT’s, ung’s to facilitate epithelial healing if ulceration is present

¨ Neurotrophic Keratitis:¡ Keratopathy occurs from loss of trigeminal

innervation to the cornea resulting in complete or partial anaesthesia

¡ The cornea is numb so the pt doesn’t blink

¡ Sx’s:ú Irritation/burning/FB sensationú Rednessú Tearingú Decreased vision

¨ Signs:¡ Decreased corneal sensation***¡ Interpalpebral SPK¡ Persistent epithelial defects in which the epithelium

at the edge of the lesion appears rolled and thickened, and is poorly attached

¡ Advanced cases may have sterile ulceration, keratitis, and/or corneal melt ú Pt may be surprisingly asymptomatic**

¨ Signs:

¨ Tx:¡ Find out the cause¡ D/C any meds that may be responsible¡ Lubricate, lubricate, lubricate***

ú Preservative free AT’s, gels, and ung’s q1h-QID¡ Topical Ab drops and/or ung (Polytrim QID, etc)¡ Taping the eyelids at night to ensure adequate

closure¡ In severe cases:

ú Patching, tarsorrhaphy, Botox to induce ptosis

¨ Tx:¡ Healing an ulcer that won’t heal

1. Autologous serum2. Prokera­ Amniotic membrane in a CL skirt

1. Also could use a scleral lens

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1. Draw 40cc of blood through venipuncture2. Centrifuge for 5 minutes @ 1500 rpm3. Centrifuging will divide the blood into its separate

components4. Place 1cc of serum in each bottle5. Add 4cc of saline to make a concentration of 20%

serum eye drops6. 20% serum eye drop concentration

• Severe dry eye patients• Graft vs. Host Disease• Filamentary Keratitis• Neurotrophic keratitis• Chronic Stainers

¨ My Regimen:¡ Zirgan 5x/day until the ulcer heals, then 3x/day for

one week¡ Oral Valtrex 500 mg 3x/day for 7-10 days¡ Artificial tears

¡ L-Lysine 2 grams daily?¡ Debride the ulcer?

¨ RTC 1 day, 4 days, 7 days

¨ Prophylactic Treatment:¡ Reduces the rate of recurrence of epithelial and

stromal keratitis by ≈ 50%ú Acyclovir 400 mg BIDú Valtrex 500 mg QDú Famvir 250 mg QD

ú L-lysine 1 gram/day

ú Frequent debilitating recurrences, bilateral involvement, or HSV infection in an only eye

¨ Visual Prognosis:¡ 90% 20/40 or better after 12 years¡ 3% 20/100 or worse after 12 years

Nathan Lighthizer, O.D., F.A.A.O.Assistant Dean, Clinical Care Services

Director of Continuing EducationChief of Specialty Care Clinics

Chief of Electrodiagnostics ClinicOklahoma College of Optometry

lighthiz@nsuok.edu