· web views first gastric cancer chemoprevention population study, conducted for over ten years...

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CONFIDENTIAL Lam S.K.

CURRICULUM VITAEShiu Kum LAM

SUMMARY BIOGRAPHY

Shiu Kum LamOBE, MBBS, MD, MRCP (UK), FHKCP (1986-2011), FHKAM (Med 1986-

2011), FRCP (Edin 1980-2011), FRCP (Lond)FRCP (Glas), FRCP (Ire), FRACP, FACP, FACG, MACG

Former dean and professor of medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong

Professor Lam joined the University of Hong Kong after graduating from it in 1967, became Chief of Gastroenterology and professor (reader) at the age of 37, Chairman of Department of Medicine in 1995-2001, and Dean of the Faculty of Medicine in 2001-2007.

Professor Lam devoted a lifetime of research on peptic ulcer and gastric cancer. His team performed the world’s first double-blind placebo-controlled study to show that peptic ulcer could be cured by eradication of Helicobacter pylori, and the world’s first gastric cancer chemoprevention population study, conducted for over ten years in Fujian, China, to show that early eradication of this stomach germ could prevent stomach can-cer. His work has helped in the reduction in incidence, and therefore mor-bidity and mortality, of duodenal ulcer worldwide, from a common disor-der affecting one in ten men to now an uncommon disease. His pioneer-ing work in gastric cancer has paved the way for the prevention of this condition in high-incidence regions such as China, where he is presently working with the Kerry Group Kuok Foundation on a programme to eradi-cate H. pylori on a population scale. His work has saved, and will continue to save, lives by the millions. His team’s latest work was the discovery that acupuncture generates a shearing acoustic wave that opens up the intracellular calcium channel, calcium being a second messenger in many cells; thus turning a two thousand years old traditional, alternative medicine into an evidence-based medicine, and opening up enormous re-search opportunities for acupuncture in the future.

He has published nine books, thirty-five book chapters and 400 pa-pers in international journals, and remains today the world’s top 1% most cited scientist in his field. He has sat on the editorial board of 18 interna-tional journals, and founded the Journal of Gastroenterology and Hepatol-ogy in 1986, of which he is now Emeritus Editor and Trustee.

Professor Lam is a fatherly doyen of gastroenterology in the Asia Pa-cific: he built, modernised and democratised its Association, APAGE, and united its physicians, surgeons, endoscopists and hepatologists to found its annual scientific conference, the Asian Pacific Digestive Week. In the

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early 1990’s, at the invitation of the Minister of Health of China, he helped to internationalise the Chinese gastroenterology conferences. The Faculty under his leadership was instrumental to the establishment of the Medical School in Tsinghua University. He remains an honorary professor in six universities in China

For his contributions to gastroenterology and medicine, he was awarded Officer of the Most Excellent Order of the British Empire (OBE) from the Queen of England in 1997, Honorary Member of the British Soci-ety of Gastroenterology (there are less than 100 such members in the world) in 1999, the Bockus medal from the World Organisation of Gas-troenterology in 2002, an honour conferred once every four years to a most distinguished gastroenterologist of the world, and Master of the American College of Gastroenterology in 2006, Professor Lam being then the only recipient of this honour in Asia. He remains a strong ally in many universities and hospitals in the world over. In 2007, The Asian Pacific Di-gestive Week honoured him by establishing the annual lecture, SK Lam Distinguished Lecture in Gastroenterology, and in 2008 the Journal of Gas-troenterology & Hepatology honoured him by establishing the SK Lam Young Investigator Award at the annual Asian Pacific Digestive Week. His colleagues in Asia regarded him as the father of modern gastroenterology in Asia.

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林兆鑫教授履歷簡介

香港大學內外全科醫學士（1967) 英國皇家內科醫學院榮授院士 (格拉斯歌) (1990)

香港大學醫學博士（1975）英國皇家內科醫學院榮授院士 (愛爾蘭) (2006)

英國皇家內科醫學院院士（1972）澳洲皇家內科醫學院榮授院士（1990)

香港醫學專科學院院士 (內科) (1993-2011) 美國內科醫學院榮授院士（1984)

香港內科醫學院院士（1986-2011) 美國腸胃科醫學院榮授院士（1986)

英國皇家內科醫學院榮授院士 (愛丁堡) (1980) 美國腸胃科醫學院榮授宗師（2006)

英國皇家內科醫學院榮授院士 (倫敦) (1983)

林兆鑫教授曾任職香港大學及瑪麗醫院四十年、是前醫學院院長。林兆鑫教授於一九六七年畢業於香港大學醫學院，其後到愛丁堡接受腸胃病學之專科訓練，著作包括九本醫學書籍，三十五篇醫學書本章節，並曾於國際醫學期刊發表超過四百篇文章。林教授為消化及肝臟國際期刊之創刊編輯，並擔任超過二十份腸胃科及內科國際醫學期刊的編委。林教授是消化學被點引率，世界前首百份一的科學家。

自一九八一年起，林教授一直擔任香港大學腸胃研究所主席一職達二十多年。他於一九八二年創辨香港腸胃學會，並於一九八七年創立中國潰瘍研究小組並出任主席。林教授於一九八六年創立消化肝臟國際期刊並出任編輯。他於一九九三年，一九九七年，及一九九八年分別創辦香港肝壽基金，香港腸胃基金，及程思遠(中國 - 國際) 肝

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炎研究基金，為腸胃及肝病作社區教育及科研。他亦於ニ零零一年創立亞洲太平洋消化病年會。

現時，林教授亦擔任多項重要職務，包括消化肝臟國際期刊基金信託人、北京肝臟基金會委員、香港肝壽基金副主席、香港腸胃健康基金副會長，以及程思遠(中國國際)肝炎研究基金信託人。林教授亦獲邀出任北京醫科大學內科學系、上海第二醫科大學、北京 301 全國觧放軍醫院，上海第二醫科大學、廣州中山醫科大學、及新彊醫科大學等客座教授一職。

林教授主要的研究包括幽門螺旋菌的感染，胃癌，胃潰瘍、非潰瘍性消化不良，腸臟機能性紊亂，及大腸癌。林教授最顯赫的研究貢獻是在十二指腸潰瘍及胃癌。他的研究組完成世界首項雙盲研究，証實消滅幽門螺旋菌，可根冶十二指腸潰瘍；並在福建長樂縣完成世界首項胃癌預防研究，經十多年隨訪，發現及早消滅幽門螺旋菌（在中國，估計每兩人有一患者），可預防胃癌，而估計每年死於胃癌的中國人，可高達三十萬。此两項研，挽回數以萬計生命。前者基本上巳被消滅，從以前世界每十人有一患者，降至為現今罕見病症，而胃癌預防亦得國際認許，控制胃癌發生率，尤其在中國，日韓，東歐等高發地區，指日可待。他現時正領導郭氏嘉里基金，展開全國性殲滅幽門螺旋菌運動。

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他的團隊於二零一一年八月作出報告，利用磁共振攝影技術，發現針灸能產生低頻剪向聲波，透過肌肉組織所形成的波導，將訊號傳遞至身體各處，還啟動了細胞內的鈣離子通道。這發現把二千年的傳统針灸醫術，一變成為有科學為據的醫，將針灸科研，推至新紀元。

由於林教授對醫學及腸胃學方面有卓越的貢獻，一九九七獲頒贈英國 OBE勳銜。二零零二年，林教授獲邀主持 BOCKUS演講並授予 BOCKUS獎章。此最高榮譽每四年於腸胃學世界會議頒發，目的為表揚於腸胃學方面有傑出成績的科學家，其卓越成就及對世界進展的貢獻。為表揚他對亞太腸胃學的貢獻，亞洲太平洋消化病年會於二零零七年，成立〝林兆鑫腸胃學講座〞，亦確認他為亞洲現代消化學之父。另消化及肝臟國際期刊亦於二零零八年，為確認他的貢獻，成立〝林兆鑫青年科學家獎〞。

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CURRICULUM VITAE

Shiu Kum LAM

PERSONAL DATA

FULL NAME: LAM, Shiu Kum, OBEDATE AND PLACE OF BIRTH:

December 9, 1942. Hong Kong

MARITAL STATUS: Married, wife Winnie Chan with 3 children, Amy (doctor), Bryan (engineer & business manage-ment), and Catrina (barrister at law)

DEGREES/DIPLOMAS: MBBS 1967MRCP (U.K.) 1972 MD 1975FRCP (Edinburgh) 1980 FRCP (London) 1983 FACP 1984 (American College of Physicians) FACG 1986 (American College of Gastroen-terology) FHKCP 1986-2011 (Hong Kong College of Physi-cian)FRCP (Glasgow) 1990FRACP 1990 (Royal Australasian College of Physicians)FHKAM 1993 (Hong Kong Academy of Medicine)FRCP (Ireland) 2006MACG 2006 (American College of Gastroen-terology)

Appointments Held

House Surgeon University Surgical UnitQueen Mary Hospital

Jul 1967-Dec 1967

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House Physician University Medical UnitQueen Mary Hospital

Jan 1968-Jun 1968

Assistant Lecturer Department of MedicineUniversity of Hong Kong

Jul 1968-Mar 1969

Lecturer Department of MedicineUniversity of Hong Kong

Apr 1969-Jun 1977

Hon. Medical Registrar and Clinical Research Fel-low

Gastrointestinal UnitWestern General Hospital Edinburgh

Sep 1971-Aug 1973

Senior Lecturer Department of MedicineUniversity of Hong Kong

Jul 1977-Oct 1980

Honorary Consultant Queen Mary Hospital Jul 1980-Mar 20, 2007

Chief Division of Gastroenterol-ogyUniversity of Hong Kong

Jul 1977-1981

Visiting Scientist Center for Ulcer Research & Education (CURE), UCLA School of Medicine, Los An-geles

Oct 1978-Sep 1979

Reader (Non-Chair Profes-sor)

Department of MedicineUniversity of Hong Kong

Nov 1980-Aug 1984

Chief Division of Gastroenterol-ogy & HepatologyUniversity of Hong Kong

1982–March 2001

Affiliated Investigator Centre for Ulcer Research & Education (CURE), Los Angeles

May 1982–present

Personal Chair (Professor) of Medicine


Sep 1984–Aug 1992

Visiting Specialist Westmead HospitalNew South Wales

Nov 24–Dec 23, 1986

Acting Head Department of MedicineUniversity of Hong Kong

Oct 13-Oct 18, 1985Nov 19-Dec 11, 1990

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Aug 16-Sep 3, 1992Feb 9-Feb 12, 1993Jul 18-Aug 21, 1993Sep 13-Sep 16, 1993Feb 14-Feb 17, 1994Feb 1-Feb 3, 1994Apr 25-Apr 29, 1994June 1-June 2, 1994May 24-May 29, 1995

2nd Chair of Medicine Department of MedicineUniversity of Hong Kong

Sep 1992–Jul 1995

Head of Medicine &Chief of Service


Aug 1995–Feb 2001

Senior Advisory Consul-tant

Divsion of Gastroenterology & HepatologyDepartment of MedcineUniversity of Hong Kong

Mar 2001-Mar 20, 2007

Dean Li Ka Shing Faculty of MedicineUniversity of Hong Kong

Mar 2001–Mar 20, 2007

First Simon K.Y. Lee Pro-fessor in Gastroenterol-ogy

Honorary Advisor


Zheng Ge Ru Foundation, Kerry Group Kuok Founda-tion

Jan 25, 2005-Mar 20, 2007

July 2010-present

Postgraduate Training

General medicine at the Department of Medicine, University of Hong Kong, under the late Professor AJS McFadzean, Professor David Todd and Professor Rosie Young, since 1968.

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Clinical and research gastroenterology at the Gastrointestinal Unit, Western General Hospital, Edinburg, under Dr. Wilfred Sircus, 1971-1973. This unit is the first administratively combined medical and surgical gastrointestinal unit in the world.

ERCP and endoscopic sphincterotomy at the Department of En-doscopy, University of Munster, West Germany, under Professor Las-zlo Safrany, 1976.

Basic and clinical research at the Center for Ulcer Research & Educa-tion, Los Angeles, under Professor Morton Grossman, Professor Jon Isenberg, and Professor John Walsh, 1978-1979.

Feasibility study in liver transplantation at the Royal Prince Alfred Hospital, Sydney, 1987.

Epidemiological research methods at the Department of Medicine, University of Sydney, under Professor Douglas Piper, 1987-1988.

Gallstone lithotripsy and contact dissolution, Department of Gas-troenterology, University of Frankfurt, 1990.

Liver transplantation at the Royal Prince Alfred Hospital, Sydney un-der Professor Neil Gallagher, and University of Brisbane, under Pro-fessor Laurie Powell, 1991-1992.

Academic Societies

Member of the Royal College of Physicians, Edinburgh, 1972. Member of the Royal College of Physicians, London, 1972. Member of the British Society of Gastroenterology, 1978. Fellow of the International Academy of Proctology, 1979. Fellow of the Royal College of Physicians, Edinburgh, 1980. Member of the American Gastroenterological Association, 1981. Trustee, International Academy of Proctology, 1981. Member of the New York Academy of Science, 1982. Council Member, Hong Kong Society of Gastroenterology, 1982-2004. Member, Asian Pacific Association for the Study of the Liver, 1983. Fellow of the Royal College of Physicians, London, 1983. Fellow of the American College of Physicians, 1984. Fellow of the American College of Gastroenterology, 1986. Fellow of the Hong Kong College of Physicians, 1986. Member of the Gastroenterological Society of Australia, 1987. Fellow of the Royal College of Physicians & Surgeons, Glasgow, 1990. Fellow of the Royal Australasian College of Physicians, 1990. Fellow of the Hong Kong Academy of Medicine, 1993. Member of the International Hepato Pancreato Biliary Association,

1994. Honorary Member, British Society of Gastroenterology, 1999 (There

are less than 100 such members in the world).

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Honorary Fellow, Hong Kong Society of Gastroenterology, 2004. Master of the American College of Gastroenterology 2006

TEACHING

Active participation in and organization of undergraduate and post-graduate teaching since joining the University of Hong Kong in l968. Taught approximately 4,000 medical undergraduates. Trained hun-dreds of specialist physicians, gastroenterologists and endoscopists.

Undergraduate teaching to dental students in 1981-1995. Instrumental to the reform of the medical curriculum into the existing

PBL-based, integrated curriculum. Led the Department of Medicine to move into the new curriculum. Attended the PBL tutor workshops. Led the Department to host the final two years of the new medical

curriculum, 2000-2002. Initiated the teaching portfolio for teachers; this will become an im-

portant tool for quality assurance since the University will introduce a new funding formula beginning in 2003-04, whereby funding will no longer be linked to fte.

Masterminded the collaborative project with Tsinghua University for the development of teaching for its new medical school.

Introduced the teaching of leadership skills to train medical students (and teaching staff) to become leaders of the society.

Visiting Professor

Visiting Specialist, Westmead Hospital, Sydney, New South Wales, Australia, Nov 24-Dec 23, 1986.

Visiting Professor, Department of Medicine, Royal North Shore Hospi-tal, University of Sydney, Apr 1987-Mar 1988.

Visiting Professor, Gastroenterology & Liver Centre, Royal Prince Al-fred Hospital, University of Sydney, Australia, Mar 1991-Feb 1992.

Guest Professor, Department of Medicine, Beijing Medical College, Beijing, China, since August 1991.

Guest Professor, Department of Medicine, Shanghai Second Medical College, China since 1996.

Guest Professor, Xinjiang Medical University, Urumuqi, Xinjiang, China, since Aug 2000.

Visiting Professor, Division of Gastroenterology & Hepatology, Chi-nese PLA General Hospital, Beijing, China, since Oct 2000.

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Guest Professor, Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou, China, since Nov 2000.

Visiting Professor, Xiamen University, Xiamen, China, since Jan 2004

Examiner

Internal Examiner, final MBBS examination, since 1976. Examiner, Hong Kong Medical Licentiate Examination, since 1981. Examiner, Non-Commonwealth Doctors Examination, since 1981. Chairman of the Hong Kong Medical Licentiate Examination Commit-

tee, 1985-1997. Examiner, MRCP(UK) Part II, London, June 1988, and Hong Kong,

since 1989. Chief Examiner, final MBBS examination, 1995-2001. Chief Examiner of Medicine, Hong Kong Medical Licentiate Examina-

tion, 1996-2000, alternate years. External Examiner for Final MBBS Examination, Department of

Medicine, The National University of Singapore, April 1-4, 1997. Examiner, Exit Assessment, Board of Advanced Internal Medicine,

The Hong Kong College of Physicians, 1998-1999. Examiner, Exit Assessment, Board of Gastroenterology & Hepatology,

The Hong Kong College of Physicians, 1998-1999. External Examiner for Diploma in Gastroenterology Nursing, School of

Professional And Continuing Education, The University of Hong Kong, 1998.

External Examiner for Masters of Internal Medicine Examination, Uni-versity Malaya, May 8-12, 2000.

Thesis Examiner

1. Ph.D, Thesis review. A case-control study of the complications of peptic ulcer disease. E. Lydick, submitted for Doctor of Philosophy in Public Health, University of California, Los Angeles, 1979.

2. M.D. Thesis Examiner. "Mucus substances in experimental cholelithi-asis". S.P. Lee, submitted for Doctor of Medicine, University of Hong Kong, 1981.

3. M.D. Thesis External Examiner. "Cimetidine in peptic ulcer studies - some pharmacological effects in man". Susan LaBrooy, submitted for Doctor of Medicine, University of Singapore, 1985.

4. M.D. Thesis External Examiner, "Peptic ulcer disease in Singapore with particular reference to racial differences". JY Kang, submitted for Doctor of Medicine, University of Singapore, 1988.

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5. M.M. Thesis External Examiner. "The general aspects of peptic ulcer: a study of the association of phenylthiocarbamide taste sensitivity and alpha-1-antitrypsin phenotypes in patients with gastric and duo-denal ulcer". ZL Li, submitted for Master of Medicine, University of Sydney, 1991.

6. PhD Thesis Examiner, “A study on the ulcerogenic mechanisms of nicotine in stress-induced gastric glandular ulcers in rats”. BS Qiu, submitted for PhD, University of Hong Kong, 1993.

7. M.D. Thesis Examiner. “Low level hepatitis B virus carriers: its detec-tion by polymerase chain reaction based assays and its clinical sig-nificance”. HT Chung, submitted for Doctor of Medicine, University of Hong Kong, 1996.

8. M.D. Thesis Examiner. “Precordial ST depression during inferior ST elevation: mechanism and significance”. CK Wong, submitted for Doctor of Medicine, University of Hong Kong, 1996.

9. M.D. Thesis Examiner. “Measurement of cerebrovascular perfusion reserve using single-photo emission tomographic techniques”. OCY Wong, submitted for Doctor of Medicine, University of Hong Kong, 1996.

10. M.D. Thesis Examiner. “Postoperative analgesia in Chinese patients: an in-depth analysis of postoperative pain management in the Queen Mary Hospital of Hong Kong”. SL Tsui, submitted for Doctor of Medicine, University of Hong Kong, 1996.

11. M.D. Thesis Examiner. “Aspects of the biological intractions between natriuretic pepetides and cultured glial cells”. VTF Yeung, submitted for Doctor of Medicine, University of Hong Kong, 1996.

12. MPhil Thesis Examiner. “Determinants and new therapeutic strategy of atrial fibrillation”. NS Lok, submitted for MPhil, University of Hong Kong, 1997.

13. M.D. Thesis Examiner. “Beta-thalassaemia in Hong Kong children”. AMC Li, submitted for Doctor of Medicine, University of Hong Kong, 1997.

14. M.D. Thesis Examiner. “Epstein-barr virus-associated carcinoma aris-ing outside the nasopharynx - a clinico-pathological and molecular study”. SY Leung, submitted for Doctor of Medicine, University of Hong Kong, 1998.

15. M.D. Thesis Examiner. “Hepatectomy for hepatocellular carcinoma”. ST Fan, submitted for Doctor of Medicine, University of Hong Kong, 1998.

16. M.D. Thesis Examiner. “Infectious complications in bone marrow transplant recipients”. KY Yuen, submitted for Doctor of Medicine, University of Hong Kong, 1998.

17. PhD Thesis Examiner. “Nonsteroidal antiinflammatory drugs and apoptosis of human gastric epithelial cells”. GH Zhu, submitted for PhD, University of Hong Kong, 1998.

18. M.D. Thesis Examiner. “Sacral and associated pelvic insufficiency fractures”. WCG Peh, submitted for Doctor of Medicine, University of Hong Kong, 1999.

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19. M.D. Thesis Examiner. “Brain function and structure in violent men-tally abnormal offenders” MTH Wong, submitted for Doctor of Medicine, University of Hong Kong, 1999.

20. M.D. Thesis Examiner. “Tumour-host interactions in non-small cell lung carcinoma”. Maria P Wong, submitted for Doctor of Medicine, University of Hong Kong, 1999.

21. M.D. Thesis Examiner. “Pathobiological study of gestational tro-phoblastic disease”. ANY Cheung, submitted for Doctor of Medicine, University of Hong Kong, 1999.

22. MPhil Thesis Examiner. “Upper gastrointestinal mucosal blood flow in health and disease”. Leslee Y Ong, submitted for MPhil, University of Hong Kong, 1999.

23. M.D. Thesis Examiner. “Clinical applications of misoprostol in obstet-rics and gynaecology”. SW Ngai , submitted for Doctor of Medicine, University of Hong Kong, 2000.

24. M.D. Thesis Examiner. “Atrial fibrillation and defibrillation”. HF Tse submitted for Doctor of Medicine, University of Hong Kong, 2000.

25. M.D. Thesis Examiner. “Helicobacter pylori-related diseases in the Chinese”. CY Wong, submitted for Doctor of Medicine, University of Hong Kong, 2000.

26. M.D. Thesis Examiner. “Hepatitis B infection and hematopoietic stem cell transplantation”. G Lau, submitted for Doctor of Medicine, Uni-versity of Hong Kong, 2000.

27. M.D. Thesis Examiner. “Electro-clinical study and gene mapping of epilepsies”. GCY Fong, submitted for Doctor of Medicine, University of Hong Kong, 2000.

28. M.D. Thesis Examiner. “A study of human endometrial function in the peri implantation period”. TC Li, submitted for Doctor of Medicine, University of Hong Kong, 2000.

29. M.D. Thesis Examiner. “Human kidney as an organ of complement synthesis”. SCW Tang, submitted for Doctor of Medicine, University of Hong Kong, 2000.

RESEARCH

Research Interests

Gastric physiology, gastrointestinal hormones, gastrointestinal microcircu-lation, genetics of peptic ulcer, epidemiology of peptic ulcer, pathophysiol-ogy of peptic ulcer, experimental ulcer models, mucosal defence mecha-nisms, motility disorders of the gut, Helicobacter pylori gastritis (with par-ticular reference to adhesins, toxins, animal model, membrane transduc-tion), therapeutic trials of peptic ulcer, non-ulcer dyspepsia, NSAID gas-

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tropathies, gastro-oesophageal reflux disease, gastrointestinal therapeutic Endoscopy (gastrointeatinal bleeding, recurrent pyogenic cholangitis), gastric cancer (epidemiology, tumour suppressor genes and oncogenes, methylation, chemoprevention), gastric cellular biology (macrophage mi-gration inhibitory factor, signal transduction).

Research Grants

1. University Research Grant for the study on "Molecular forms of gas-trin after proximal gastric vagotomy, truncal vagotomy and pyloro-plasty and truncal vagotomy and antrectomy".

2. University Research Grant for the study on "Gastric mucosal morphol-ogy, gastric acid and gastrin secretions in pulmonary emphysema".

3. Wing Lung Medical Research Fund for the study on "Postprandial serum gastrin in relation to gastrin sensitivity in peptic ulcers".

4. University Research Grant and Medical Faculty Research Grant for the project "Drug trials in peptic ulcer".

5. University Research Grant for the study on "24 hour gastric and duo-denal pH, and nocturnal acid output in duodenal ulcer".

6. Peptic Ulcer Research Fund, University of Hong Kong.7. University Research Grant for the study on "Gastroduodenal mucosal

blood flow in peptic ulcer", 1992.8. University Research Grant for the study on “Relationship of Heli-

cobacter pylori and gastric cancer in China”, 1993-95.9. Research Grant Council Grant on “Assessment of the risk/aetiological

factors of gastric cancer in a defined population - a cohort study”, 1995-96 (HK$129,200).

10. CRCG on “To measure the gastroduodenal mucosal blood flow, nitric oxide and prostaglandin content of the gastric mucosa at different phase of healing or duodenal ulcer, before and after eradication of Helicobacter pylori (Hp)”, 1996-97 (HK$125,000).

11. Research Grant Council grant on “Helicobacter pylori lectins - identifi-cation, characterization, and purification for clinical applications”, 1996-98 (HK$337,000).

12. University Research Grant for the study on “A study on the prolifera-tive activity and apoptosis in gastric epithelial cells of helicobacter pylori (HP) infected patients on non-steroidal anti-inflammatory drugs (NSAIDs) before and after treatment with antibiotics and misopros-tol”, 1997-98 (HK$85,000).

13. Research Grant Council grant on “Assessment of helicobacter pylori and dietary factors in gastric carcinogenesis: correlation with cell pro-liferation, apoptosis and intracellular signal transduction pathway”, 1997-99 (HK$686,880).

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14. CRCG Block Grant on “Macrophage migration inhibitory factor expres-sion in chronic gastritis and peptic ulcer in patients with helicobacter pylori”, 1999 (HK$90,000).

15. Research Grant Council Grant on “Chemoprevention of gastric cancer by treatment of Helicobacter pylori infection”, 1999-2002 (HK$2,175,800).

16. Research Grant Council Grant on “Chemoprevention of gastric cancer by intervention with Helicobacter pylori and cyclooxygenase path-way”, 2001-2002 (HK$2,000,000).

17. Research Grant Council Grant on “Multiple-component psychotherapy for patients with functional dyspepsia: A double-blind matched-case controlled study”, 2002-2003 (HK$580,127).

18. Seed Funding for Basic Research on “Gene therapy for GI cancer by targeting survivin with adeno-associated virus”, November 2002 (HK$120,000).

19. Seed Funding for Basic Research on “c-Jun NH2-terminal kinase 1 modulates apoptosis of gastric cancer cells through the upregulation of XAF1”, January 2004 (HK$120,000).

20. Research Grant Council Grant on “Treatment of gastrointestinal can-cer by targeting survivin using adeno-associated virus gene delivery system”, 2004-2005 (HK$939,968).

21. CRCG Small Project Funding on “The Prevalence of Obstructive Sleep Apnea Syndrome (OSAS) in Patients with Gastro-Oesophageal Reflux Disease (GERD) and the Effects of Proton Pump Inhibitor Therapy on OSAS and Quality of Sleep in Hong Kong Chinese”, 2004-2005 (HK$61,800).

Research Students

Supervision of postgraduate students and doctors, mainly local and from China, but also regional and international, 1-10 in a given year for 25 years. One to three Chinese doctors from major centres have been invited every year to spend usually one year in the Department of Medicine to do research on gastric pathophysiology and to undergo training in gastroenterology for the past 15 years.

China Ulcer Research Group

Founded and chaired the China Ulcer Research Group since 1987. This group consists of leading investigators in the Six Great Regions of China, namely, Huadong (China East), Zhongnan (Central South), Huabei (China North), Xibei (North West), Dongbei (North East), and Xinan (West South),

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distributed evenly in the north (of the Yangtze River) and south of China. The group meets about once a year and conduct research on gastric dis-orders. It has completed on project of the epidemiology of peptic ulcer and gastric cancer in China.

Centre for Alimentary Research & Education (CARE)

Convenor of a weekly gastrointestinal research meeting since 1981, which started from a size of two researchers to the present group of 25. This is an informal lunch meeting, where free flow of ideas particularly from young investigators is encouraged, where intense collaboration is pro-moted, where protocols are formed, where weekly data are updated and discussed, and where initial results, abstracts and full papers are pre-sented and debated upon. In 1996 The Centre for Alimentary Research & Education (CARE) was formally established, consisting of 20 investigators (physicians, surgeons, pharmacologists, pathologists, and microbiolo-gists,) 5 Scientific Officers, 21 postgraduate students, 5 specially trained nurses, 24 research assistants, and 5 technicians. It is supported by the Simon KY Lee Digestive Diseases Laboratory, H. pylori Culture Laboratory. It is linked to the China Ulcer Research Group and has a wide network of collaborators in China, as well as in Australia, Canada, Germany, Japan, Netherlands, Malaysia, Singapore, UK, USA.

PROFESSIONAL ACTIVITIES

Physician in charge of the Combined Unit of Gastroenterology of the Department of Medicine and Department of Surgery, University of Hong Kong 1973-1982. This was the first combined unit established in Hong Kong, but was later dissolved because of ward re-arrange-ments, although a close collaboration between physicians and sur-geons has always been maintained.

Physician in charge of Division of Gastroenterology and Hepatology, Department of Medicine, University of Hong Kong, 1981-2001. Under my direction, this unit has evolved from a basic ward to a unit con-sisting of one 16-bed male and one 11-bed female wards, one medi-cal gastrointestinal clinic, one medical peptic ulcer clinic, one gas-trointestinal oncology clinic, one hepatitis clinic, one hepatitis vaccine clinic, one combined gastrointestinal clinic, one combined hepato-bil-iary clinic, gastrointestinal endosocpy service and clinical gastroin-testinal laboratory for gastric secretory studies, (including special

17


tests such as dose-response pentagastrin stimulation, 24-hour ambu-latory pH, intragastraic titration), motility studies, Helicobacter pylori breath and serological tests, malabsorption tests, radioimmunoassay for gastrin, somatostatin, gastric inhibitory polypeptide, vasoactive intestinal polypeptide, pancreatic polypeptide, epidermal growth fac-tor, neurotensin and hepatitis B and C markers, ultra-sonography, and measurement of gastrointestinal microcirculation.

Consultant gastroenterologist, Queen Mary Hospital, 1977-present. General Gastroenterology, Gastroduodenoscopy, Colonoscopy and Polypectomy, Oesophagoscopy with Dilatation of Stricture and Scle-rotherapy for varices, Endoscopic Retrograde Cholangio- Pancreatog-raphy, Endoscopic Sphincterotomy and Removal of Biliary Stones, Transnasal Biliary Drainage, Temporary and Permanent Biliary Drainage by Endoscopic Endoprosthesis, Percutaneous Contact Disso-lution of Gall stones, Laser Treatment of Gastrointestinal Cancer, Laser and Electrocoagulation Treatment for Gastrointestinal Bleeding, Endoscopic Measurement of Gastric Mucosal Blood Flow.

Physician in charge of Gastrointestinal Research Laboratory, dealing with research on the developement of techniques for measuring gas-trointestinal microcirculation, including the use of LASER doppler method, hydrogen clearance method, and reflectance spectropho-tometry method, radioimmunoassay of gastrointestinal peptides in-cluding gastrin, somatostatin and epidermal growth factor, measure-ment of gastrointestinal motility, measurement of gastric secretions, measurement of serum pepsinogen 1, Helicobacter pylori breath and serological tests, histochemical studies of the gastrointestinal mu-cosa including Enterochromaffin-like (ECL) cells, parietal cell culture, epidemiological techniques, and computer medicine for gastroen-terology.

Physician in charge of Endoscopic Accessories Workshop, which pro-duces and repairs cannulas, catheters, papillotomes, polypectomy snares, baskets for removal of biliary stones, biliary stents, endo-scopic injectors for sclerotherapy, endoscopic electrodes for the mea-surement of gastrointestinal mucosal blood flow.

Physician-in-charge of Liver Transplant Working Group, Queen Mary Hospital, 1992. Instrumental to the collaborative development of the Liver Transplant programme, Department of Surgery, The University of Hong Kong.

Physician-in-charge, Division of General Medicine, 1997-2001. As a result of specialization, general medicine and holistic patient care need re-emphasis, and the Division of General Medicine was formally re-established in the Department in 1997.

Chief of Service of Department of Medicine, Queen Mary Hospital, 1995-2001.

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ADMINISTRATION

University

Committee, Medical Faculty Library, University of Hong Kong, 1981-1984.

Committee, University Library, University of Hong Kong, 1982-1984. Admissions Committee, Faculty of Medicine, University of Hong Kong,

1983-1986. Senate, The University of Hong Kong, 1984- March 20, 2007. Ethics Committee, Faculty of Medicine, University of Hong Kong,

1984-1986. Computer Committee, Faculty of Medicine, University of Hong Kong,

1988-1992 Chairman, Post-Retiral Medical Benefit Scheme, University of Hong

Kong, 1990. Disciplinary Committee, University of Hong Kong, 1992. Appointment Board for Senior Teachers, University of Hong Kong,

1994-1995. Chairman, Committee for the Selection of Professional and Adminis-

trative Staff, University of Hong Kong, 1995-1996. Head, Department of Medicine, The University of Hong Kong, 1995-

2001. Chairman, Clinical Trials Advisory Committee, Clinical Trials Centre,

Faculty of Medicine, 1997-2001. Convenor, Research Assessment Exercise, The University of Hong

Kong, 1998. Director, Centre for Alimentary Research and Education, The Univer-

sity of Hong Kong, 1998- March 20, 2007. Director of Administration and Finance, HKU-Pasteur Research Centre

Ltd., 2000. Member, Institute of Molecular Biology Supervisory Board, The Uni-

versity of Hong Kong, September 2000–August 2002. Chairman, Re-development of Li Shu Fan Site (CenCAM), Faculty of

Medicine, The University of Hong Kong, March 1, 2001-March 20, 2007.

Non-student Members of the Senate, the Committee for the Selection of the New Vice-Chancellor, The University of Hong Kong, 2001-2002.

Dean, Li Ka Shing Faculty of Medicine, The University of Hong Kong, March 1, 2001-- March 20, 2007.

Member, Board of Faculty of Dentistry, The University of Hong Kong, March 1, 2001-February 28, 2004.

Member, General Purpose Committee, The University of Hong Kong, 2001-2005.

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Chairman, Sub-Committee on Resources Allocation, Faculty of Medicine, The University of Hong Kong, 2001-March 20, 2007.

Chairman, Client/Consultants Meeting for New Medical Complex, Fac-ulty of Medicine, The University of Hong Kong, 2001-March 20, 2007.

Chairman, Sub-committee for Appointment of Honorary Senior Teach-ers, Faculty of Medicine, The University of Hong Kong, 2001-March 20, 2007.

Member, Committee of Management of School of Traditional Chinese Medicine, Faculty of Medicine, The University of Hong Kong, 2001-March 20, 2007.

Member, HKU Foundation - Deans Committee, March 2004-March 20, 2007.

Member, Honorary Degrees Committee, The University of Hong Kong, April 23, 2004-April 22, 2007.

Member, Committee of Enquiry into Possible Good Cause, The Univer-sity of Hong Kong, July 1, 2006- March 20, 2007.

Hospital (QMH) and Professional

Physician in charge of a combined gastrointestinal unit 1973-1982 and of the Division of Gastroenterology & Hepatology 1982-2001. This has now evolved into a unit with six physicians (1 professor, 1 reader, 1 lecturer, 1 consultant, 3 senior medical officers) and three medical registrars, and two teams (hepatobiliary and alimentary canal) of surgeons.

Physician in charge of two general medical wards 1985-1995. Head and Chief of Service, Department of Medicine, University of

Hong Kong, August 1995-February 2001. The department has 33 University academic staff (11 chairs, 5 professors, 11 associate pro-fessors, 5 assistant professors, 4 research assistant professors), 2 honorary professors, 163 part-time honorary associate/assistant pro-fessors, 89 Hospital Authority doctors (12 consultants, 16 senior med-ical officers, 61 medical offers), 22 house officers, and 284 nurses. The Head is in charge of Internal Medicine in 4 hospitals: Queen Mary Hospital, Tung Wah Hospital, Grantham Hospital, and Fung Yiu King Hospital, with a total of 1,024 bed assignments, Medical Subspecial-ties Clinics with a total of 85 clinic sessions per week, Apleichau Fam-ily Medicine Unit with 11 clinic sessions per week. In 2000, the De-partment has served a total of 41,487 in-patients and 194,487 out-patients.

Chairman of Organizing Committee of many international confer-ences of gastroenterology, endoscopy, and hepatology held in Hong Kong, since 1981.

Establishment and Chief Editor of an international journal: Journal of Gastroenterology and Hepatology, (published by Blackwell Scientific, Melbourne), 1986-2002.

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Chairman of the Peptic Ulcer Research Group of China, since 1987. Postgraduate training for young doctors in general medicine, gas-

troenterology, hepatology and endoscopy to junior doctors in the De-partment of Medicine, University of Hong Kong as part of a rotation program and to junior doctors in many of the teaching hospitals in Hong Kong, as well as to overseas post graduates, particularly those in the Asian-Pacific region.

Chairman and founder of the Weekly Gastrointestinal Meeting at Queen Mary Hospital started since 1974, attended by gastrointestinal physicians, surgeons, radiologists, pathologists, physiologists, micro-biologists, registrars, general practitioners, house-staffs as well as ju-nior doctors and senior medical students.

Councillor, Hong Kong College of Physicians, 1993-2006. Member, Education & Accreditation Committee, Hong Kong College of

Physicians, 1993-2001. Chairman, Subspecialty Board in Gastroenterology & Hepatology,

Hong Kong College of Physicians, 1996-1999. Chairman, Subspecialty Board in Advanced Internal Medicine, Hong

Kong College of Physicians, June 1996-May 2001. Chairman, Basic Physician Training Board, Hong Kong College of

Physicians, 1996-2001. Member, Hospital Planning Committee, Queen Mary Hospital, 1999. Member, Subspecialty Board in Gastroenterology & Hepatology, Hong

Kong College of Physicians, June 1999-May 2005. Member, Cluster Medical Committee (formerly known as Hospital

Medical Committee), Queen Mary Hospital, 1995-March 20, 2007. Member, Professional Standard Review Committee, Queen Mary Hos-

pital, 2001-2002. Member, Research Committee, Queen Mary Hospital, 2001-2002. Member, Hospital Governing Committee, Queen Mary Hospital/Tsan

Yuk Hospital, April 1, 2001-March 20, 2007. Member, Basic Physician Training Board, Hong Kong College of Physi-

cians, 2001-2003. Member, Subspecialty Board in Advanced Internal Medicine, Hong

Kong College of Physicians, June 2001-May 2005. Member, Appointment Board for Chief of Service, Queen Mary Hospi-

tal, 2001-2004. Member, Hospital Disciplinary Committee, Queen Mary Hospital,

2001–2004. Honorary Advisor, Education & Training Committee, Hong Kong Sana-

torium Hospital, May 2004-March 20, 2007.

Government

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Externship Sub-Committee, Licentiate Committee of the Medical Council of Hong Kong, 1985-1997.

Selection Board, Senior Medical Officer, Hospital Authority, 1992. Selection Board, Consultant Physician, Hospital Authority, as repre-

sentative from Academy of Medicine, 1995. Chairman, Examination Subcommittee, Licentiate Committee of the

Medical Council of Hong Kong, 1995-1997. Member, Standing Committee on Registrable Qualifications and

Quotable Appointments of the Medical Council of Hong Kong, July 1995-January 1997.

Member, Hospital Governing Committee, Grantham Hospital, 1995–March 2007.

Convenor, Biology & Life Science Panel, Research Assessment Exer-cise, University Grants Committee, 1996.

Member, Licentiate Committee of the Medical Council of Hong Kong, December 1996-1997.

Chairman, Training Subcommittee of the Co-ordinating Committee in Internal Medicine, Hospital Authority, Hong Kong, 1996-September 2001.

Chairman, Committee of Training and Education, COC, Hospital Au-thority, 1996.

Member, Internship Sub-Committee, Licentiate Committee of the Medical Council of Hong Kong, 1997.

Member, Ethics Committee, Princess Margaret Hospital, 1997-Febru-ary 2001.

Member, Fund-Raising Subcommittee for Master Redevelopment Project, Hospital Governing Committee, Grantham Hospital, 1998.

Deputy Convenor, Biology & Life Science Panel, Research Assessment Exercise, University Grants Committee, 1999.

Honorary Adviser for the Continuous Medical Education Programme, The Association of Licentiates of Medical Council of Hong Kong, 2001.

Member, Hospital Governing Committee, Hong Kong Eye Hospital, 2001-2002.

Member, Hospital Governing Committee, Grantham Hospital, 2001-March 2007.

Board Member, Hospital Authority, 2001-March 20, 2007. Member, Human Resources Committee, Hospital Authority, 2001-

2003. Member, Medical Services Development Committee, Hospital Author-

ity, 2001-March 2007. Member, Central Internship Committee, Hospital Authority, 2001-

March 2007. Member, Liaison Committee, Department of Ophthalmology & Visual

Science, Chinese University of Hong Kong, 2001-March 2007. Honorary Advisor, Institute of Health Care, Hospital Authority, July

2002-June 2004.

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Honorary Advisor, Institute of Advanced Nursing Studies, Hospital Au-thority, September 2004-March 2007.

COMMUNITY

Member, Rotary Club of Hong Kong South 1978-1988. Vice-Chairman, Hong Kong Liver Foundation, since 1993. Member, Board of Directors, The Hong Kong Tuberculosis, Chest &

Heart Diseases Association, 1995-2007. Vice-Chairman, Hong Kong Digestive Foundation, since 1997. Vice-Chairman and Member, Board of Directors, The Hong Kong Kid-

ney Foundation, 1997-2006. Founder and Trustee, Cheng Si Yuan (China-International) Hepatitis

Research Foundation since 1998. Patron, Management Society for Healthcare Professionals, since May

2002.

DEVELOPMENT AND CONTRIBUTIONS TO GASTROENTEROLOGY AND HEP-ATOLOGY IN HONG KONG, CHINA & ASIA

1. Established the Endoscopy Unit of the Department of Medicine, Uni-versity of Hong Kong, 1973. Pioneered the technique of Endoscopic Retrograde Cholangio-Pancreatography in 1975, Endoscopic Sphinc-terotomy in 1976, and Endscopic Biliary Stenting in 1978 in Hong Kong. Developed the subspecialty of gastroenterology and hepatol-ogy in Hong Kong.

2. Established the Peptic Ulcer Research Fund, part of which has been used to fund trainees and researchers from China and Asia to spend a period of 3 -12 months in the Division of Gastroenterology of this De-partment, since 1980.

3. Founded the Hong Kong Society of Gastroenterology in 1981.4. Founded the Endoscopy Chapter of the Hong Kong Society of Gas-

troenterology in 1984.5. Chaired the Ad Hoc Committee of the Asian-Pacific Association of

Gastroenterology to establish new statutes of the Association to re-form the Association to an active and democratic organization, 1984-1992. Led the Association to adopt the new constitution in 1992 and the election of the first president by a democratic process in 1996.

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6. Instrumental to the founding of the Hong Kong Society of Endoscopy Nurses in 1986.

7. Founded the Journal of Gastroenterology and Hepatology, with Black-well Scientific as publisher, in 1986. This serves as the international, but particularly the regional, forum for research discoveries in gas-troenterology and hepatology.

8. Established and chaired the China Ulcer Research Group in 1987.9. Established the biennial International Conference of Gastroenterology

Hong Kong - China, since 1991 with the purpose of importing and ex-porting the science of gastroenterology into and out of China. The bi-ennial conference was organized at a personal request of the Minister of Health of China, and the gentleman’s agreement was that the con-ference would be organized biennially till 1997, by which time, I be-lieved, China would be ready to organize international conference on its own.

10. Founded the Hong Kong Liver Foundation in 1993, the Foundation is governed by a group of community leaders keenly interested in com-munity service, and which is dedicated to improve the health of the liver in Hong Kong through public education and support of research.

11. Founded The Hong Kong Digestive Foundation in 1997, with a new concept of governance, in that the Foundation is governed by a group of community leaders keenly interested in community service, and which is dedicated to improve the health of the digestive system in Hong Kong through public education and support of research.

12. Formally established CARE, Centre for Alimentary Research & Educa-tion, The University of Hong Kong 1998.

13. Founded The Cheng Si Yuan (China-International) Hepatitis Research Foundation in 1998. The Foundation is based in Hong Kong and run by a group of community-minded businessmen with major connec-tions with mainland China, and the Foundation has been graced with the name of Cheng Si Yuan, the Vice-Chairman of the Standing Com-mittee of the People’s Congress. The Hon. Professor Wu Jie Ping, Vice-Chairman of the Standing Committee of the People’s Congress, is the Honorary President and Mr. C.H. Tung (former Chief Executive of The Hong Kong SAR) is the Patron. The Foundation promotes edu-cation and research in hepatitis in China. It has organized two inter-national hepatitis conferences in Shenzhen and Shanghai (atten-dance 1,300). The Foundation signed an agreement with The Chi-nese Foundation for Hepatitis Prevention and Control on May 24, 2001 in The People’s Hall Beijing, in the presence of three Vice-Chair-men of the Standing Committee of the People’s Congress, the Minis-ter of Health of China, and Mr. Donald Tsang (former Chief Secretary of Hong Kong SAR) to conduct an hepatitis B vaccination programme for the poor children in western China.

14. Founded the Asian Pacific Digestive Week (APDW) conference to be held yearly in Asia in 2001. The world of gastroenterology is now grouped into 3 major zones, with the annual Digestive Disease Week in North America, and the annual United European Gastroenterologi-

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cal Week in Europe.

15. Led and commenced in 2011 a project of the Kerry Group Kuok Foun-dation to eradicate Helicobacter pylori, which affects one in two Chi-nese, in China, as a preventive measure for gastric cancer which kills 300,000 Chinese annually, and as part of a national philanthropic project to lift the poor in China out of poverty.

DEVELOPMENTS AND CONTRIBUTIONS DURING HEADSHIP OF MEDICINE, 1995-2001

1. Established Immunology and Medical Physics in 1999 and Dermatol-ogy in 2000 as medical specialties in the Department, and redefined General Medicine as a distinct medical specialty with emphasis on holistic care. All trainees are encouraged to go through this core spe-cialty in addition to their elective specialty in medicine.

2. Reformed 12 medical specialties (Cardiology, Critical Care Medicine, Dermatology, Endocrinology & Metabolism, Gastroenterology & Hepa-tology, General Medicine, Geriatrics, Haematology & Oncology, Im-munology & Rheumatology, Molecular Medicine and Genetics, Nephrology, Neurology, Respiratory Medicine) into structural divisions with space, wards, staff, budget, and laboratories.

3. Established three new laboratories: Immunology, Medical Physics and Cellular Biology, so that there are, in addition to the Molecular and Gene Laboratory, four departmental core laboratories. These central facilities help departmental research to focus on these four vital and basic mechanisms.

4. Led the Faculty and Department to actively engage in the medical curriculum reform, and the department to host the final two years of the new curriculum.

5. Flattened the administrative hierarchy of the Department so that the Head is in effect a chairman, with a board of directors and executive committees. All divisions are required to install four weekly to monthly communication mechanisms: professional clinical meeting, quality assurance meeting, research meeting, and business meeting, with emphasis on open, fair, transparent and principle-based admin-istration and promotion on e-management. The Head meets all staff (from medical officers to chair professors) individually each year, and adopts a knock-and-talk openness to staff.

6. Promoted a culture of equality between Hospital Authority staff and University staff; both staff now share similar clinical, teaching and re-search work.

7. Established the Research Retreat and Medical Forum to be held in January and July every year since 1995. Up to 150 abstracts are pre-sented at the Retreat, and these are published in a local journal. The

25


Forum has become a legend for general practitioners and trainees in Hong Kong.

8. The Department has 11 chair and 5 full professors, a unique feature amongst all tertiary institutions in Hong Kong. In year 2000, it has 540 publications, $38,477,383.35 million current research grants, and 50 postgraduate students and visiting researchers.

9. Instrumental to the founding of the Hong Kong University – Pasteur Research Centre in 2000. This center is engaged in microbial ge-nomics research, in close collaboration with the Institut Pasteur of Paris.

DEVELOPMENTS AND CONTRIBUTIONS DURING DEANSHIP, MARCH 2001-MARCH 2007

1. Established through a Faculty retreat a blueprint for research direc-tions and organization, including the concept of Faculty-based Re-search Programmes, whereby multidisciplinary research groups with excellent track record and outstanding research projects would be re-warded with resources including research space. It was envisaged that a handful of such programmes would be formed, and these would be evaluated at regular intervals for fitness of continuation.

2. Successfully bid for an HKU earmark funding (HK$ 135 million) for the establishment of the Human Genome Centre and attracted Professor Tsui Lap-Chee to be its steering chairman. This became a university-based Faculty Programme of core research facilities.

3. Successfully bid for a University Development Fund (HK$35 million) for the establishment of a research programme for Emerging Infec-tions, as well as for an AIDS Trust Fund (HK$8 million) for the estab-lishment of an AIDS Laboratory.

4. Instrumental to the establishment of The AIDS Institute under the di-rectorship of Dr. David D.Y. Ho with funding from the Government.

5. Successfully enlisted Professor Robert Webster from St. Jude’s through the Distinguished Visiting Professor Scheme to set up The In-fluenza Centre, Professor Sham from Guy’s through the same scheme to research on genomic statistics, as well as Professor Paul Vanhutte also through the same scheme to establish The Biopharmaceutical Centre.

6. Led to the formulation of The Human Research Institute for the Study of Complementary and Alternative Medicine to be built on the old Li Shu Fan site, and to its approval by UGC; helped to attract Professor Tommy YC Cheng from Yale University to steer the Consortium for Research in Chinese Medicine.

7. Cofounded The Clinical Trial Centre in 1998 with Professor Johanne Karlberg, and became its first chairman. The HKU Clinical Trials Cen-tre is the only academic contract research organization in this region

26


with the highest quality of clinical trial support services, serving as an interface between academics and the industries. It has signed over 130 institutional contracts with 25 major international pharmaceutical companies. Its central laboratory has just won accreditation from the College of American Pathologists, an accreditation body of the high-est international standard.

8. Instrumental to the establishment of the HKU Pasteur Research Cen-tre in 2000. The Centre focuses on research in microbial genomics. Within the short period of time since its inauguration, the Centre has developed transcriptome analysis to identify the behaviour of genes of interest, and installed a general platform for genome annotation.

9. Recruited Professor Jonathan Lamb from Edinburgh in 2002 to help setting up a Biotech Company in the Faculty of Medicine. The com-pany would initially be set up as a “screening” company to analyze the biological activity of compounds supplied by industry in a range of genetic, cellular and in vivo model systems, i.e. to provide service/contract research. Furthermore as need demands, the com-pany can be used to provide a research hotel/incubator facility for the commercialisation of HKU intellectual property. The Company will en-able the University to enhance its outreach activities to the Pharma-ceutical and Biotech industry with a view to increasing our exposure and links to future potential industrial partners. The long-term objec-tive is to enable the University to establish itself as the regional cen-tre of excellence in the provision of complete solutions to industry from laboratory research services to clinical trials, setting standards and quality benchmarks comparable to the best international prac-tices for other similar centres in the region to follow.

10. Masterminded the collaborative teaching project for the new medical school of Tsinghua University and established a Cheng Yu Tung Ts-inghua Fund for its support.

11. Masterminded The Eye Institute with a new chair in ophthalmology for teaching and research in ophthalmology, which has hitherto been completely under CUHK, to be established under the tripartite part-nership of HKU, HA and HK Sanatorium, and raised HK$20 million as a startup fund.

12. Rigorous promotion of Faculty and its curriculum to secondary schools, and successfully widened the gap from the CUHK medical faculty in academic quality of the students admitted through JUPAS. Mounted a highly successful Teaching & Learning Quality Process Re-view (TLQPR).

13. Reformed the governance of the Faculty of Medicine, moving it to the appointed instead of the elected dean system, zoning the 17 depart-ments into three groups: health sciences, medical sciences, and sur-gical sciences, each having a mix of clinical science and basic science departments, and a chairman, and installing a corporate structure with a core management team (CMT) consisting of the dean, asso-ciate deans, group chairmen and elected basic science representa-tive, an advisory body of department heads, and Faculty board as

27


stakeholders with check and balance for the operations of the CMT as one clear function.

14. Introduced Assistant Deanship to encourage young and able faculty members to participate in faculty administration, thereby generating in them a sense of ownership for the Faculty. Introduced Assistant Professorship scheme for RAP to retain bright RAP. Introduced joint appointment scheme to encourage cross-department appointment and thereby interdisciplinary collaboration.

15. Revamped the Faculty External Affairs and Fund Raising Office. The community now views the academic activities of the Faculty with a new respect.

16. Improved the working relationship of teaching staff with the Hospital Authority staff at the Queen Mary Hospital by engendering a new cul-ture of collaboration (院系一家), through two joint retreats (2002 and 2003) with the hospital.

17. Introduced the concept of leadership engine for the Faculty: training students and staff to become leaders of the society.

18. Masterminded the blueprint for Biomedical Hong Kong.

ACADEMIC HONOURS

International

President, Quadrennial Conference on Immunology of the Gut, 6th World Congress of Gastroenterology, Madrid, June 1-9, 1978.

Treasurer, Organizing Committee, Meeting of International Associa-tion for the study of the Liver and Asian Pacific Association for the study of the Liver, Hong Kong, Feb 8-12, 1982.

Chairman, Organizing Committee, International Symposium on Physi-ology and Pathophysiology of the Alimentary System Microcirculation, Hong Kong, March 28-30, 1983.

Chairman, Organizing Committee, Western Pacific Regional Workshop on Viral Hepatitis B Infection: Vaccine and Control, Hong Kong, Sep-tember 10-11, 1983.

Member, Ethics Committee, Organization Mondiale de Gastro-En-terologie, 1984-1992.

Chairman, 4th International Symposium on Sucralfate, Sao Paulo, 1986.

Chairman, World Symposium on Peptic Ulcer, World Congress of Gas-troenterology, Sao Paulo, 1986.

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Chairman, World Symposium on Endoscopic Auxiliary Methods and New Techniques, World Congress of Gastroenterology, Sao Paulo, 1986.

Chairman, Ad Hoc Committee for the initiation and activation of the Asian Pacific Association of Gastroenterology, 1986-1988.

Chairman, International Liaison Committee, Asian Pacific Association of Gastroenterology, 1988-1996.

Chairman, Organizing Committee, Digestive Disease Weekend Hong Kong, 1990.

Member, International Relations Committee, American College of Gastroenterology, since 1992.

Chairman, Organizing Committee of a clinical trail on a new proton pump inhibitor, 4th United European Gastroenterology Week, Berlin, September 17-21, 1995.

Chairman, 90th Falk Symposium: Update on Hepatobiliary Diseases 1996.

Chairman, 1997 Asia Pacific Consensus for the Management of H. py-lori, Singapore, August 29-31, 1997.

Council Member, Beijing Liver Foundation since 1997. Vice President, Asian Pacific Association of Gastroenterology, 1997-

2000. Honorary Member, British Society of Gastroenterology, since 1997

(There are less than 100 such members in the world). Vice-Chairman, Asian-Pacific, Committee of Guidelines and Publica-

tions of OMGE, since 1998. Trustee, The Journal of Gastroenterology & Hepatology Foundation,

since 1998. President, Asian Pacific Association of Gastroenterology, 2000-2004. Chairman, Steering Committee, Asian Pacific Digestive Week, since

2000. Councillor, World Organization of Gastroenterology (OMGE), 2000. Chairman, OMGE Research Advisory Committee, February 2002-

2005.

National

Chairman and Founder, China Ulcer Research Group, China, since 1987.

Vice-President, International Conference of Gastroenterology - Hong Kong & Beijing, jointly organized by the American College of Gas-troenterology, Chinese Medical Association - Chinese Society of Gas-troenterology, and Hong Kong Society of Gastroenterology, 1991.

Chairman, Organizing Committee, International AGA/Singapore Gas-troenterological Meeting, 1995.

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Vice-Chairman, Organizing Committee, Third International Confer-ence of Gastroenterology - Hong Kong & Shanghai, Nov 10-16, 1995.

Chairman, Faculty Meeting of the Asian Consensus on Helicobacter pylori, May 12, 1997.

Co-chairman, International Symposium on Hepatology, Beijing, PR China, August 12-15, 1997.

Chairman, Alimentary Diseases Week Hong Kong 1997, Hong Kong Convention & Exhibition Centre, Dec 12-18, 1997, Hong Kong.

Chairman of Bidding Committee for the World Congress of Gastroen-terology for Hong Kong, 1998.

Chairman, Scientific Committee & Organizing Committee, 1st Scien-tific Meeting of Cheng Si Yuan (China-International) Hepatitis Re-search Foundation, Shenzhen, PR China, Aug 15-16, 1998.

Co-chairman, World Chinese Congress of Digestion, Beijing, PR China, Oct 19-22, 1998.

Chairman, Cheng Si Yuan (China-International) Hepatitis Research Foundation, 1998–2001.

Chairman of “Liver Diseases in the New Millennium”, 4th Shanghai In-ternational Symposium on Liver Cancer and Hepatology and Second Scientific Meeting of Cheng Si Yuan (China-International) Hepatitis Research Foundation, Shanghai, PR China, Sept 23-26, 2000.

Class 1 Award, National Scientific Progress, 2008-J-233-1-01-R02 for the cancer prevention study in Changle.

Editorial Board Consultant, Journal of Chinese Digestive Disease, 1 Jan 2009 – 31 Dec 2011.

Hong Kong

Vice-President, Hong Kong Society of Gastroenterology, 1982-1984. President, Hong Kong Society of Gastroenterology, 1984-1986 and

1996-1998. Co-chairman, Scientific Programme and Organizing Committee, Joint

Scientific Conference, Gastroenterological Society of Australia and Hong Kong Society of Gastroenterology, 1988.

Co-chairman, Scientific Programme and Organizing Committee, Hong Kong Canadian Conference of Gastroenterology and Hepatology, Hong Kong, 1989.

Chairman of Bidding Committee for the World Congress of Gastroen-terology for Hong Kong, 1990.

Councillor, Hong Kong College of Physicians, since 1993. Vice-Chairman, Organizing Committee, Second International Confer-

ence of Gastroenterology - Hong Kong & Chengdu, 1993. Chairman, Biology & Life Science Panel, Research Assessment Exer-

cise, University Grants Committee, 1996. Officer of the Most Excellent Order of the British Empire (OBE), 1997.

30


Honorary Advisor, The Hong Kong Society of Endoscopy Nurses, 1997.

Honorary Consultant, Princess Margaret Hospital, April 1998 - March 2001.

Member, Scientific Committee, Asian Clinical Trials Conference, Octo-ber 1998.

Vice Chairman, Asian Clinical Trials Conference, Hong Kong, October 1998.

Member of Working Group on Gastroenterology & Hepatology Devel-opment Service Development Subcommittee in Internal Medicine, 1999-2000.

Chairman, Local Organising Committee, Asian Pacific Congress of Gastroenterology, Hong Kong, 2000.

Chairman, Bidding Committee, Asian-Pacific Congress of Gastroen-terology, Hong Kong, 2000.

Chairman, Local Organizing Committee, Inaugural Scientific Sympo-sium of the Centre of Alimentary Research and Education (CARE), Hong Kong, September 17-19, 2000.

Council Member, The University of Hong Kong Medical Alumni, since 2001-2007.

Board Member, Hospital Authority, Hong Kong, 2001-2007. Honorary Advisor, Institute of Clinical Neuropsychology, since August

2002. Honorary Fellow, Management Society for Healthcare Professionals,

since December 2002. Honorary Fellow, Hong Kong Society of Gastroenterology, 2004. Advisor, Conference on Biomedical Engineering 2004 – “Integrating

Science and Technology in the Healthcare Industry”, Hong Kong, Sep-tember 23-25, 2004.

Honorary Advisor, Zheng Ge Ru Foundation, Kerry Group Kuok Foun-dation to help lift the poor in China and Hong Kong out of poverty, July 2010 to present.

EDITORIAL ACTIVITIES IN INTERNATIONAL JOURNALS

Reviewer

Reviewer, DIGESTION, since 1976. Reviewer, GASTROENTEROLOGY, since 1979. Reviewer, DIG DIS & SCI, since 1983. Reviewer, SCAND J GASTROENTEROL, since 1984. Reviewer, GUT, since 1985. Reviewer, J GASTROENTEROL HEPATOL, since 1986.

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Reviewer, JOURNAL OF CLINICAL INVESTIGATION, since 1989. Reviewer, DIG DIS, since 1990. Reviewer, AUSTRALIAN MEDICAL JOURNAL, since 1991. Reviewer, AM J GASTROENTEROLOGY since 1993. Reviewer, JOURNAL OF AMERICAN MEDICAL ASSOCIATION, SOUTH-

EAST ASIA, since 1995. Reviewer, EUROPEAN J GASTROENTEROL, since 1995. Reviewer, Drugs International, since 2010

Associate Editor

Associate Editor, Gastroenterology Section, Am J PROCTOLOGY, GAS-TROEN TEROLOGY, COLON AND RECTAL SURGERY, 1979-1983.

Associate Editor, MED PROGRESS, since 1981. Associate Editor, CHINESE JOURNAL OF CLINICAL HEPATOLOGY, since

1985.

Editor

Founding and Chief Editor, J GASTROENTEROL HEPATOL, published by Blackwell Scientific, 1986-2002.

Editorial Board, ALIMENTARY PHARMACOLOGY AND THERAPEUTICS, since 1987.

Editorial Board, SURVEY DIG DIS, 1988-1998 Editorial Board, DRUG INVESTIGATION, since 1988. Editorial Board, INTERNATIONAL REVIEW OF DIG DIS, since 1989. Editorial Board, International Advisory Committee, GUT since 1992. Editorial Board, DRUGS & THERAPY PERSPECTIVES, 1993-2008. Editorial Board, MEDICINE DIGEST, since 1993. Editorial Board, GUT, 1996-1999. Editorial Board, JOURNAL OF GASTROENTEROLOGY, 1996-1999 Editorial Board, CHINA NATIONAL JOURNAL OF NEW GASTROEN-

TEROLOGY, since 1997. Editorial Board, AMER J GASTROENTEROL, since 1997. Editorial Board, DIGESTIVE DISEASES, since 1998. Editorial Board, CURRENT GASTROENTEROLOGY REPORTS, since

1998. Editorial Board, CURRENT TREATMENT OPTIONS IN GASTROENTEROL-

OGY, 1998. Editorial Board, JOURNAL OF CLINICAL ONCOLOGY, 1999. Associate Editor, WORLD CHINESE JOURNAL OF DIGESTOLOGY, 2000-

2003. Editorial Board, DIGESTIVE AND LIVER DISEASE, 2001-2004.

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International Editor Board, CHINESE HEPATOLOGY, since 2001. Editorial Board, NATIONAL MEDICAL JOURNAL OF CHINA, since 2002. Consultant, Editorial Board, CHINESE JOURNAL GASTROENTEROLOGY,

June 2002-June 2004. Member, Editorial Advisory Board, MIMS GASTROENTEROLOGY

GUIDE, since December 2002 Honorary Editorial Advisor, Regional Editorial Board, MIMS Asia Drug

Directories, since April 1, 2003. Member, Editorial Board, WORLD JOURNAL OF GASTROENTEROLOGY,

since November 2004. Member, Advisory Board, NATURE CLINICAL PRACTICE GASTROEN-

TEROLOGY & HEPATOLOGY 2004 Editorial Board Consultant, Journal of Chinese Digestive Disease, 1

Jan 2009 – 31 Dec 2011.

INTERNATIONAL CONFERENCES ORGANIZED

1. Meeting of International Association for the study of the Liver and Asian Pacific Association for the study of the Liver, Hong Kong, Feb 8-12, 1982

2. International Symposium on Physiology and Pathophysiology of the

Alimentary System Microcirculation, Hong Kong, March 28-30, 1983 3. Chairman, Organizing Committee, Western Pacific Regional Work-

shop on Viral Hepatitis B Infection: Vaccine and Control, Hong Kong, September 10-11, 1983

4. Internationl Conference of Gastroenterology - Hong Kong and Beijing,

November 1-5, 1991 5. Second International Conference of Gastroenterology, Hong Kong -

Chengdu, August 27-September 2 1993 6. Chairman, Organizing Committee, International AGA/Singapore Gas-

troenterological Meeting, 1995 7. 3rd International Conference of Gastroenterology, Hong Kong/Shang-

hai, November 6-10, 1995 8. Chairman, 90th Falk Symposium: Update on Hepatobiliary Diseases

Hong Kong,1996

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9. 1997 Asia Pacific Consensus for the Management of H. pylori, Singa-pore, August 29-31, 1997

10. Alimentary Disease Week Hong Kong, December 12-17, 1997

11. 1st International Academic Conference of Cheng Si Yuan (China-Int'l) Hepatitis Re-search Foundation cum Symposium on Treatment of Chronic Hepatitis B held in Shen-zhen, 1998

12. Asian Clinical Trials Conference 1998, Hong Kong, October 25-27,

1998. 13. Hong Kong/Beijing Medical Forum, July 3-5, 1999

14. Inaugural Scientific Symposium of the Centre of Alimentary Research and Education (CARE), Hong Kong, September 17-19, 1999

15. CARE Symposium. Asian Pacific Congress of Gastroenterology, Hong

Kong, March 10-14, 2000 16. APAGE Vision, Mission & Strategic Retreat (organized as new Presi-

dent of Asian Pacific Association of Gastroenterology), Hangzhou, Au-gust 5-7, 2000

17. Co-President, 1st Shanghai-Hong Kong International Liver Congress,

Shanghai, September 23-26, 2000

18. Asian Pacific Congress of Gastroenterology, Hong Kong, March 10-14, 2000

19. Hong Kong Medical Forum Meeting, Nanjing, China, July 9-11, 2001

20. Hong Kong Medical Forum Meeting, Kunming, China, July 8-10, 2002 Chairman, Steering Committee of the Asian Pacific Digestive Week, 2001 – 2008 (annual congresses of Asia):

21. 2001 Sept 23-27 Sydney, Australia22. 2002 Feb 24-Mar 1 Bangkok, Thailand23. 2003 Sept 27-30 Singapore24. 2004 Oct 4-7 Beijing, China25. 2005 Sept 26-28 Seoul, South Korea26. 2006 Nov 26-29 Cebu, Philippines27. 2007 Oct 15-18 Kobe, Japan28. 2008 Sept 13-16 New Delhi, India

29. Co-President, 2nd Hong Kong-Shanghai International Liver Congress, Hong Kong, Feb 14-17, 2004

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30. Co-President, 3rd Shanghai-Hong Kong International Liver Congress, Shanghai, March 25-28, 2006

31. Chairman, Fuzhou Exhibition: Campaign: "No Stomach Cancer for

Our Next Generations", December 12-13, 2006 32. Co-President, 4 th Hong Kong – Shanghai International Liver Con-

gress, Hong Kong, June 12 – 15, 2008 33. Co-Chairman, Healthcare City Project with Mayo Clinic, Sanya,

Hainan, China, November 1-2, 2008.

INTERNATIONAL AND OVERSEAS LECTURES BY INVITATION

1. "Recurrent Pyogenic Cholangitis". Gastrointestinal Unit, Western General Hospital, Edinburgh, September 26, 1978.

2. "Maximal Acid Output and Postprandial Gastrin in Duodenal Ulcer". Center for Ulcer Research and Education, UCLA School of Medicine, Los Angeles, April 24, 1979.

3. "New Aspects in Pathophysiology and Treatment of Duodenal Ulcer". Department of Gastroenterology, A & M University of Texas, Temple, May 18, 1979.

4. "Gastrin and Somatostatin - their measurement and function". 6th Asian-Pacific Congress in Gastroenterology, Auckland, February 10-14, 1980.

5. "The control of gastric secretion" 6th Asian-Pacific Congress in Gas-troenterology, Auckland, February 10-14, 1980.

6. "Genetics in peptic ulcer - physiologic abnormalities and Heterogene-ity" - International Workshop of Genetics and Heterogeneity of Com-mon Gastrointestinal Disorders, organized by the Digestive Disease Branch of the National Institutes of Health, United States of America, Indian Wells, California, March 17-19, 1980.

7. "Pathophysiology and treatment of peptic ulcer". Department of Gas-troenterology, Zhung Shan Medical School, Canton, July 15, 1980.

8. "Endoscopic retrograde cholangiopancreatography and sphinctero-tomy". Department of Gastroenterology, Zhung Shan Medical School, Canton, July 15, 1980.

9. "Treatment of peptic ulcer in general practice". Chinese Medical As-sociation, Fat Shan, July 16, 1980.

10. "Endoscopic retrograde cholangiopancreatography in clinical prac-tice". Chinese Medical Association, Fat Shan, July 16, 1980.

11. "Treatment of peptic ulcer - new approach with old medicine: antacid and bismuth". Department of Medicine, University of Parma, Italy, September 13, 1980.

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12. "New insight in pathophysiology and treatment of peptic ulcer". De-partment of Gastroenterology, Bahidol University, Bangkok, Septem-ber 30, 1980.

13. "Peptic ulcer in Hong Kong". First National Conference on Internal Medicine, Canton, China, December 7, 1980.

14. "Endoscopic sphincterotomy for removal of bile duct stones in recur-rent pyogenic cholangitis". First National Conference in Internal Medicine, Canton, China, December 7, 1980.

15. "Duodenal ucler - news from Hong Kong" - Center for Ulcer Research and Education (CURE), UCLA School of Medicine, Veteran Administra-tion Center, Los Angeles, May 28, 1981.

16. "Duodenal Ulcer Heterogeneity". Gastrointestinal Unit, Western Gen-eral Hospital, Edinburgh, Scotland, September 16, 1981.

17. "Aetiological Factors of Peptic Ulcer", at the Update in Gastroenterol-ogy, Singapore Society of Gastroenterology and University of Singa-pore, Singapore, November 28, 1981.

18. "Treatment of Duodenal Ulcer - News from Hong Kong". Center for Ulcer Research and Education (CURE), UCLA School of Medicine, Vet-erans Administration Center, Los Angeles, May 26, 1982.

19. "Treatment of Duodenal Ulcer". Department of Gastroenterology, Harbour-UCLA Medical Center, Los Angeles, May 27, 1982.

20. "Acid and gastrin in peptic ulcer", Sucralfate Symposium, Taipei, March 18, 1983.

21. "Recent advances in peptic ulcer". Department of Internal Medicine, Capital Hospital, Beijing, April 3, 1983.

22. "Aetiology of peptic ulcer". Gastrointestinal Unit, First Hospital of the Tianjin Medical College, Tianjin, April 6, 1983.

23. "Hepatitis B viral infection". Society of Gastroenterology of Tianjin, Tianjin, April 7, 1983.

24. "Medical Management of peptic ulcer", 25th Anniversary Scientific Meeting, Gastroenterological Society of Australia, Singapore, May 13, 1983.

25. "Heterogeous origin of hyperacidity in duodenal ulcer". Workshop on Genetic and Clinical Aspects of Persinogen, De Baak, Noordwijk, Lei-den, Netherlands, October 19, 1983.

26. "Epidemiology and Pathophysiology of Duodenal Ulcer". Department of Gastroenterology, University of Nijmegen, the Netherlands, Octo-ber 21, 1983.

27. "Safety of hepatitis vaccine and future vaccines". Asian Pacific Asso-ciation for the Study of Liver. Bangkok, January 12-14, 1984.

28. "Epidemiology and Pathophysiology of Duodenal Ulcer". Department of Gastroenterology, Jichi Medical School, Utsunomiya, Japan, January 25, 1984.

29. "Epidemiological, Genetic, Clinical and Pathophysiological Hetero-geneity of Duodenal Ulcer". Department of Gastroenterology, Kyoto Univeristy Medical School, Kyoto University Hospital, Kyoto, Japan. January 27, 1984.

30. "Epidemiology and Pathophysiology of Duodenal Ulcer". Department of Gastroenterology, National University of Taiwan. January 30, 1984.

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31. "Pathogenesis and pathophysiology of duodenal ulcer". Fifth Philip-pines Society of Gastroenterology Annual Convention, Manila, Febru-ary 25, 1984.

32. "Rational approach to the treatment of Peptic Ulcer Disease". The Philippine Society of Gastroenterology Meeting, Philippine, February 25, 1984.

33. "Pathogenesis and pathophysiology of peptic ulcer". Cebu Medical Society, May 17, 1984.

34. "The pathogenesis and pathophysiology of duodenal ulcer". Peptic Ulcer Update, Gastroenterological Society of Australia, October 13, 1984.

35. "The prognostic factors of peptic ulcer healing". Annual Scientific Meeting, Keynote Lecture, Gastroenterological Society of Australia, October 16, 1984.

36. "Medical treatment of peptic ulcer - an Asian experience". Singapore Society of Gastroenterology, Singapore, July 22, 1985.

37. "Medical treatment of peptic ulcer - an Asian experience". Malaysian Medical Association and Society of Gastroenterology and Hepatology, Kuala Lumpur, July 23, 1985.

38. "Medical treatment of peptic ulcer - an Asian experience". Gastroen-terological Association of Thailand, Bangkok, July 25, 1985.

39. "Peptic Ulcers, East and West". Retiral Scientific Conference of Dr. W. Sircus and Mr. W.P. Small, Western General Hospital, Edinburgh, Sep-tember 24, 1985.

40. "Predictive factors of peptic ulcer healing". 32nd Japanese Research Meeting on Pepsinogen, Tokyo, October 26, 1985.

41. "Hyperpepsinogenemia I and hyperacidity in early-and-late-onset duodenal ulcer". International Workshop on Aspartic Proteinases, Tokyo, October 27, 1985.

42. "Treatment of duodenal ulcer in Chinese". Guangdong Association of Gastroenterology Conference, Xin Hui, December 12, 1985.

43. "Prostaglandins in the treatment of duodenal-ulcer - current status". Canadian Society of Gastroenterology, Torronto, April 1986.

44. "Use of prostanoids in the treatment of peptic ulcer". Australian Col-lege of Physicians, Hobart, Tasmania, May 6, 1986.

45. "Update on gastritis". Indonesian Society of Gastroenterology and Council of the Asian Pacific Association of Gastroenterology, Update in Gastroenterology, Jakarta, July 26, 1986.

46. "The future treatment of peptic ulcer". In What Is New in Gastroente rology Postgraduate Course, World Congress of Gastroenterology, Sao Paulo, September 7, 1986.

47. "Sucralfate versus cimetidine in duodenal ulcer - factors affecting healing and relapse". 4th International Symposium of Sucralfate, Sao paulo, September 8, 1986.

48. "Epidemiology of peptic ulcer disease". Workshop on epidemiology of gastrointestinal disease, World Congress of Gastroenterology, Sao Paulo, September 10, 1986.

49. "Cytoprotective agents in peptic ulcer". World Congress of Gastroen terology, Sao Paulo, September 11,1986.

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50. "Current concepts of gastritis". Indonesian Society of Gastroentero logy, Annual Scientific Meeting, Mataram and Bali, October 3-5, 1986.

51. "New clues and new viewpoints on the aetiology of peptic ulcer". De-partment of Gastroenterology, Royal North Shore Hospital, Sydney, July 2, 1987.

52. "Pathogenesis of peptic ulcer". Department of Gastroenterology, Concord Hospital, Sydney, June 15, 1987.

53. "Recent advances in upper gastrointestinal diseases", debate on "That surgery is an outmoded approach to the management of peptic ulcer disease", and "The aetiopathogenesis of peptic ulcer". Royal Australasian College of Surgeons and New Zealand Society of Gas-troenterology meetings, August 18-21, 1987.

54. "Sucralfate overcomes adverse effect of cigarette smoking on duode-nal ulcer healing and prolongs subsequent remission". 10th Interna-tional Congress of Pharmacology, Sydney, August 23-29, 1987.

55. "Aspects of ulcer disease". Gastrointestinal Unit, University of New South Wales, Prince of Wales Hospital, September 1, 1987.

56. Annual Scientific Meeting, Recent Advances in Therapy, Adelaide, September 4, 1987.

57. "Aetio-pathogenesis of peptic ulcer". Third National Meeting of Chi-nese Society of Digestive Diseases, Kuming, Yunnan, China, Novem-ber 24-26, 1987.

58. "Recent trends in peptic ulcer". Department of Medicine, Concord Hospital, Sydney, Australia, December 3, 1987.

59. "Gastric emptying, motility, and functional dyspepsia". Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia, Jan-uary 27, 1988.

60. "Role of infectious agents in peptic ulcer disease". International Gas-troenterology and Liver Update, Brisbane, Australia, February 4-6, 1988.

61. "New clues in the pathogenesis of peptic ulcer". A.W. Morrow Gastro enterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, Australia, February 16, 1988.

62. "Sucralfate overcomes adverse effects of cigarette smoking on duo-denal ulcer healing and prolongs subsequent remission". Scientific Meeting on Cytoprotection - Sucralfate Updated, Menzies at Rialto, Melbourne, Australia, February 29, 1988.

63. "Sucralfate overcomes adverse effects of cigarette smoking on duo-denal ulcer healing and prolongs subsequent remission". Scientific Meeting on Cytoprotection - Sucralfate Updated, Opera House, Syd-ney, Australia, March 1, 1988.

64. "Peptic ulcer - aetiology and new ideas", "Antral G cell hyperplasia" and "Mesenteric insufficiency". Departments of Gastroenterology and Medicine, University of Newcastle, Royal Newcastle Hospital, New castle, Australia, March 16-17, 1988.

65. "Resistant duodenal ulcer", "Zollinger-Ellison syndrome" and "Bleed-ing gastric ulcer". Department of Gastroenterology, Westmead Hos-pital, Sydney, Australia, March 23, 1988.

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66. "Clinical efficacy of sucralfate in the short-term treatment of peptic ulcer", 20th Anniversary Sucralfate Symposium, Tokyo, July 16, 1988.

67. "Aetio-pathogenesis of peptic ulcer". 21st Century Forum: Peptic Ul-cer Today, Tokyo, July 17, 1988.

68. "Do antacids, especially at low dose, protect gastric mucosal dam-age?". 6th International Experimental Ulcer Conference, Jerusalem, August 28-32, 1988.

69. "The medical treatment of refractory duodenal ulcers". International Conference in Gastroenterology, Rome, September 4-10, 1988.

70. "Ulcer epidemiology, the world and Hong Kong". First Scientific Meet-ing of the China Ulcer Group, Hong Kong, October 5, 1988.

71. "Treatment of peptic ulcer recurrence by intermittent therapy". Joint Scientific Conference, Gastroenterological Society of Australia and Hong Kong Society of Gastroenterology, Hong Kong, October 5-7, 1988.

72. "Medical treatment of peptic ulcer". 8th Asian Pacific Congress of Gastroenterology and 5th Asian Pacific Congress of Digestive En-dosco py, Seoul, October 9-13, 1988.

73. "Peptic ulcer - from aetiology to cause". 8th Asian Pacific Congress of Gastroenterology and 5th Asian Pacific Congress of Digestive En-doscopy, Seoul, October 9-13, 1988.

74. "The role of acid in peptic ulcer". 8th Asian Pacific Congress of Gas-troenterology and 5th Asian Pacific Congress of Digestive Endoscopy, Seoul, October 9-13, 1988.

75. "Smoking and acid reduction in ulcer healing and relapse". 5th Inter-national Sucralfate Symposium, Miami, USA, October 19-23, 1988.

76. "Campylobacter pylori", "Peptic ulcer treatment", "Control of acid se-cretion". Thailand Society of Gastroenterology, Bangkok, November 30 - December 1, 1988.

77. "Clinical trials in Campylobacter pylori". 1st Asian Teaching Course in Gastroenterology and Endoscopy, Penang, December 2-6, 1988.

78. "Peptic ulcer". 1st Asian Teaching Course in Gastroenterology and Endoscopy, Penang, December 2-6, 1988.

79. "Is there `life' after nocturnal acid suppression?". 1st Asian Teaching Course in Gastroenterology and Endoscopy, Penang, December 2-6, 1988.

80. "What causes peptic ulcer: new clues, new ideas, and new therapeu-tic implications". International Healthcare Conference, Theme - Healthcare 2000, Hong Kong, December 10-13, 1988.

81. "Stress ulcer bleeding in the critically ill". International Symposium on Portal Hypertension, Tokyo, February 25, 1989.

82. "Asian experience with omeprazole in acid-related disorders". Sym-posium on the First Proton Pump Inhibitor, Manila, March 4, 1989.

83. "Recent advances in Campylobacter pylori". Gastroenterological Conference of the Central-South Provinces of China, Guangzhou, May 23-26, 1989.

84. "Why does sucralfate heal ulcer?" Holland Digestive Disease Week, 75th Anniversary of the Dutch Society of Gastroenterology, Amster-dam, June 20-24, 1989.

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85. "Is Campylobacter pylori a culprit?" Department of Medicine, Univer-sity of Bern, Bern, Switzerland, June 26, 1989.

86. "Acid inhibition and mucosal protection in the treatment of peptic ul-cer". Department of Medicine, University of Zurich, Zurich, Switzer-land, June 28, 1989.

87. "Role of smoking and campylobacter pylori in refractory ulcer". Hong Kong Canadian Conference of Gastroenterology and Hepatology, Hong Kong, November 30-December 3, 1989.

88. "Prevention of peptic ulcer relapse". Hong Kong Canadian Confer-ence of Gastroenterology and Hepatology, Hong Kong, November 30 - December 3, 1989.

89. "Ulcer epidemiology in China". Second Scientific Conference of the China Ulcer Group, Hong Kong, December 2, 1989.

90. "Prevention and management of Relapse of Peptic Ulcer". 3rd Na-tional Conference of the Indian Academy of Gastroenterology, New Delhi, India, February 16-17, 1990.

91. "Stress ulcer bleeding in the critically ill". Francisco Roman Memorial Lecture in Gastrointestinal Endoscopy, Philippine Society of Gastroen-terology Annual Conference, March 16-17, 1990.

92. "Endoscopic management of bile duct stone". Philippine Society of Gastroenterology Annual Conference, March 16-17, 1990.

93. "What's new in endoscopy?" Philippine Society of Gastroenterology Annual Conference, March 16-17,1990.

94. "Epidemiology of Peptic Ulcer in Asia". Asian Pacific Physicians's Con-ference, Sabah Medical Association and Society of GAstsroenterology and Hepatology of Malaysia, Kota Kinabalu, April 17, 1990.

95. "Why do ulcers occur, recur and concur?" Philippine College of Physi-cians Conference, Manila, May 3-5, 1990.

96. "What is an intractable peptic ulcer?". European Digestive Disease Week, Vienna, Austria, June 5-9, 1990.

97. "Relapse prophylaxis and relapses after treatment of duodenal ulcer". European Digestive Disease Week, Viena, Austria, June 5-9, 1990.

98. "Acute and long-term treatment of peptic ulcer". International Sym-posium on Losec and Acid Inhibition, Bangkok, June 23, 1990.

99. "New areas of clinical application for sucralfate". 6th International Sucralfate Symposium, Gold Coast, Australia, August 19-21, 1990.

100. "Refractory ulcer". Clinical vignette on peptic ulcer, World Con-gresses of Gastroenterology, Sydney, August 27, 1990.

101. "Clinical indications and efficacy of sucralfate". World Congresses of Gastroenterology, Sydney, August 29, 1990.

102. "Geographical factors of peptic ulcer". World Congresses of Gas-troenterology, Sydney, August 30, 1990.

103. Debate on "This house believes that cytoprotection should be the pri-mary aim of treatment of peptic ulcer". New Zealand Society of Gas-troenterology Satellite Meeting of the World Congresses of Gastroen-terology, Auckland, New Zealand, September 2-4, 1990.

104. "Gastrointestinal Bleeding". South African Gastroenterological Soci-ety Conference, Cape Town, October 5-9, 1990.

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105. "Helicobacter pylori and duodenal ulcer". South African Gastroen-terological Society Conference, Cape Town, October 5-9, 1990.

106. "Risk factors for intractability and recurrence of peptic ulcer". Gas-troenterological Society of the Republic of China Autumn Convention, Taipei, Taiwan, November 15, 1990.

107. "Recent advances in gastrointestinal bleeding". Department of Surgery, University of Sydney, Royal Prince Alfred Hospital, Sydney, Australia, September, 1991.

108. "Treatment of peptic ulcer - 1991". Australian Chinese Medical Asso-ciation Inaugural Conference, New South Wales, October 16, 1991.

109. "Peptic ulcer - genetic and environmental factors". Internationl Con-ference of Gastroenterology - Hong Kong and Beijing, November 1, 1991.

110. "Clinical efficacy of sucralfate in the treatmnet of gastrointestinal dis-order: an overview". Symposium on The Ideal Therapy for Gastroin-testinal Disorder, International Conference of Gastroenterology - Hong Kong and Beijing, November 1, 1991.

111. "Peptic ulcer - strengthening the mucosa". International Conference of Gastroenterology - Hong Kong and Beijing, November 5, 1991.

112. "Antacid therapy today in duodenal ulcer". Workshop on Antacids, Lisbon, Portugal, November 15-17,1991.

113. "Gastroenterology in Hong Kong and Sydney - a tale of two cities". Gut Club, New South Wales, Australia, November 28, 1991.

114. "Epidemiolgy, pathogenesis and aetiology of peptic ulcer". Depart-ment of Gastroenterology, St. Vincents Hospital, Sydney, December 2, 1991.

115. "Epidemiology, aetiology and pathogenesis of peptic ulcer". Inaugu-ral Lecture as Guest Professor, Third Teaching Hospital, Beijing Medi-cal University, Beijing, May 26, 1992.

116. "Is Helicobacter pylori the real culprit in duodenal ulcer?" Medical Conference, Eastern Suburbs Medical Association, New South Wales, Australia, August 19, 1992.

117. "Epidemiology and genetics of peptic ulcer". Japanese Society of Gastroenterology Biannual Conference, Utsunomiya, Japan, October 13, 1992

118. "Gastrointestinal bleeding - a new agenda". 80th Anniversary Cele-bration, Beijing Medical University, Beijing, October 25, 1992.

119. "Aetiology and pathogenesis of duodenal ulcer". 1992 Shanghai In-ternational Symposium on Gastroenterology, Shanghai, China, No-vember 9-11, 1992.

120. "What is new in peptic ulcer - aetiology, pathogenesis and manage-ment". 9th Asian Pacific Congress of Gastroenterology, Bangkok, Thailand, November 29-December 3, 1992.

121. "Treatment of peptic ulcer in relation to the effect of nicotine on gas-tric mucosal blood flow and acid secretion". International Symposium on Current Topics in Gastroenterology, Tokyo Women's Medical Col-lege, Tokyo, Japan, December 12-13, 1992.

122. "Aetiology and pathogenesis of peptic ulcer". Japanese Society of Gastroenterology Conference, Kyoto, Japan, March 29-31, 1993.

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123. "Sydney classification of gastritis". Japanese Society of Gastroen-terology Conference, Kyoto, Japan, March 29-31, 1993.

124. "Peptic ulcer 1993". Associacao dos Medicos de Clinica Geral de Macau Meeting, Macau, April 24, 1993.

125. "Gastrointestinal Bleeding - A New Agenda". Gastroenterology Up-date, The Gastroenterological and Digestive Endoscopy Society of Sri Lanka, Columbo, June 13-14, 1993.

126. “Acid and H. pylori in the pathogenesis of peptic ulcer”. Second In-ternational Conference of Gastroenterology, Hong Kong - Chengdu, August 27- September 2 1993.

127. “Gastritis and gastric cancer”. Second International Conference of Gastroenterology, Hong Kong - Chengdu, August 27-September 2 1993.

128. “Aetiology and treatment of peptic ulcer - projection into the future”. International Symposium on Pepter Ulcer - From Experimental Ulcer to Clinical Uses, Hong Kong, January 6-9, 1994.

129. “Epidemiology, pathogenesis and treatment of peptic ulcer”. Shan-tao Medical Symposium, March 31-April 2, 1994

130. “Stress ulcer bleeding”. Shantao Medical Symposium, March 31-April 2, 1994.

131. “Chronic gastritis - clinical significance”. Taisho International Confer-ence of Gastroenterology, Hakone, Japan, April 6-7, 1994.

132. “New prospects of Helicobacter pylori eradication”. 7th International Sucralfate Symposium, Santa Barbara, USA, September 25-27, 1994.

133. Pakistan Society of Gastroenterology, Peshawa, Pakistan, March 27-30, 1995.

134. “Update on dyspepsia”. 14th WONCA World Conference, Hong Kong, June 10-14, 1995.

135. Epidemiology of non-ulcerdyspepsia”. International AGA/Singapore Gastroenterological Meeting, Singapore, September 6-9, 1995.

136. “The use of antibiotics in peptic ulcer”. Beijing International Sympo-sium on Peptic Ulcer, Beijing, China, October 8-10, 1995.

137. The gloom of Changle”. Sun Yat-sen Lecture, 3rd International Con-ference of Gastroenterology, Hong Kong/Shanghai, November 6-10, 1995.

138. “Helicobacter pylori and gastric cancer, perspectives from China”. Capetown, South Africa, December 4-6, 1995.

139. “Current strategies in ulcer management with special reference to Helicobacter pylori eradication”. Capetown, South Africa, December 4-6, 1995.

140. “Helicobacter pylori - perspectives from China and therapeutic inter-vention”. The Gastroenterological Association Symposium on Heli-cobacter pylori, Chiang-Rai, Thailand, January 31-February 2, 1996.

141. “Should we be aggressively perusing H. pylori in the Western Pacific?”. The First Western Pacific Helicobacter Congress, Guangzhou, China, February 27-28, 1996.

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142. “The Hong Kong/China Helicobacter pylori experience”. The First Western Pacific Helicobacter Congress, Guangzhou, China, February 27-28, 1996.

143. “H. pylori: Epidemiology in the Tropics”. 2nd International Confer-ence of Tropical Gastroenterology and Hepatology, Jaipur, India, March 14-16, 1996.

144. “Helicobacter pylori, peptic ulcer and gastric cancer”. School of Post-graduate Medical Education and Training, The University of Hong Kong, April 19, 1996.

145. “The use of antibiotics in peptic ulcer”. 6th Taisho International Sym-posium on Gastroenterology, Shimoda, Japan, April 21-26, 1996.

146. “Does treatment of Helicobacter pylori with antibiotics alone heal duodenal ulcer? A randomised double-blind placebo-controlled study”. American Gastroenterological Association, Digestive Disease Week, San Francisco, U.S.A., May 18-24, 1996.

147. “Chronic dyspepsia: rationale for investigations”. First Asian-Pacific Working Party on Functional Upper Gastrointestinal Disorders, Kuala Lumpur, Malaysia, July 3-4, 1996

148. “Currently management strategies for peptic ulcer disease”. The Stomach 1996 International Meeting, Kuala Lumpur, Malaysia, July 3-6, 1996

149. “Epidemiology of peptic ulcer disease”. The Stomach 1996 Interna-tional Meeting, Kuala Lumpur, Malaysia, July 3-6, 1996.

150. “Epidemiological observations in peptic ulcer in this century and their relevance to the understanding of its aetiology”. Frontiers in Gas-troenterology - a view from Maputo, South Africa, August 9-11, 1996.

151. “Clinical significance of chronic gastritis”. Frontiers in Gastroenterol-ogy - a view from Maputo, South Africa, August 9-11, 1996.

152. “The gloom of Changle”. Frontiers in Gastroenterology - a view from Maputo, South Africa, August 9-11, 1996.

153. “Medical Education in Hong Kong with special reference to training in Gastroenterology”. 10th Asian-Pacific Congress of Gastroenterology (APCGE), 7th Asian-Pacific Congress of Digestive Endoscopy (APCDE), Yokohama, Japan, September 19-23, 1996.

154. “Can proton pump inhibitors change the natural history of peptic ul-cer?”. 10th Asian-Pacific Congress of Gastroenterology (APCGE), 7th Asian-Pacific Congress of Digestive Endoscopy (APCDE), Yokohama, Japan, September 19-23, 1996.

155. “Medical ethics in this region”. 10th Asian-Pacific Congress of Gas-troenterology (APCGE), 7th Asian-Pacific Congress of Digestive En-doscopy (APCDE), Yokohama, Japan, September 19-23, 1996.

156. “H. pylori related disease - perspectives from Asia”. 37th Annual Sci-entific Conference of the Indian Society of Gastroenterology, Chandi-garh, October 27-30, 1996.

157. “Management of Dyspepsia 1997”. 1996 Shanghai International Con-ference of Gastroenterology, Shanghai, P.R. China, November 28-30, 1996.

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158. “Pathogenesis of gastric cancer, perspectives from China”. Talk to the Gastroenterological Society of Singapore, Singapore, March 31-April 4, 1997.

159. “Management of Dyspepsia 1997”. Talk to the Department of Medicine, University of Singapore, Singapore, March 31-April 4, 1997.

160. “Helicobacter pylori and gastric cancer: perspectives from China”. In-ternational Gastroenterology Congress ‘97, Istanbul, June 4-7, 1997.

161. “Management of dyspepsia”. International Gastroenterology Con-gress ‘97, Istanbul, June 4-7, 1997.

162. “Testing & treating H. pylori in Asia”. Asian Consensus on Helicobac-ter pylori, Alimentary Disease Week Hong Kong, December 12-17, 1997.

163. “Prerequisites of adequate approach to dyspepsia: differences be-tween the West and the East”. Helicobacter pylori: Basic mecha-nisms to clinical cure 1998, San Diego, USA, January 18-21, 1998.

164. “The gloom of Changle”. Grand round, Department of Gastroenterol-ogy, University of San Diego, January 20, 1998.

165. “Chronic Hepatitis B and treatment“. Lecture to Hepatology Center of Shenzhen Luohu Hospital, Shenzhen, February 28-March 1, 1998.

166. “Gastroesophageal Reflux Disease”. Plenary lecture to GI Motility Conference, Zhaoqing, China, March 28-29, 1998.

167. “The basis for approach to dyspepsia - differences between the east and the west”. Lecture to Tarzana Hospital, affiliated with UCLA School of Medicine, LA, USA, May 12, 1998.

168. “Dyspepsia and gastric cancer”. Lecture to Department of Gastroen-terology, University of California, Irvine, CA, USA, May 14, 1998.

169. “Gastric cancer - lessons from Changle”. The 6th Digestive Disease & the 2nd Digestive Endoscopy Conference, Chinese Medical Association (Guangzhou), Guangzhou, China, May 29-31, 1998.

170. “Diagnosis & treatment of dyspepsia”. Scientific Meeting of Sun Yat-Sen University Hong Kong Alumni Association, Hong Kong, June 14, 1998.

171. “Evolution of peptic ulcer treatment - From acid neutralization to Heli-cobacter pylori eradication”. State-of-the-Art lecture, The 2nd West-ern Pacific Congress of Helicobacter pylori, Kota Kinabalu, Malaysia, June 25-27, 1998.

172. “Asian Pacific consensus on H pylori - why and how?” The 2nd Western Pacific Congress of Helicobacter pylori, Kota Kinabalu, Malaysia, June 25-27, 1998.

173. “Gastric cancer studies in China”. The 2nd Western Pacific Congress of Helicobacter pylori, Kota Kinabalu, Malaysia, June 25-27, 1998.

174. “How to perform good medical research”. University programme: Core Curriculum in Cardiology, Institute of Cardiovascular Science and Medicine, Hong Kong, July 11-12, 1998.

175. “Gastric cancer”. World Congress of Gastroenterology, Vienna, Sep-tember 6-11, 1998.

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176. “Global approach to the management of dyspepsia – difference be-tween the east and west”. World Chinese Congress of Digestion, Bei-jing, October 20-22, 1998.

177. “Why Clinical Trials in Asia?” Asian Clinical Trials Conference 1998, Hong Kong, October 25-27, 1998.

178. “Management of H. pylori infection in the development world”. The 39th Annual Conference of the Indian Society of Gastroenterology, Pune, India, October 29 – November 2, 1998.

179. “Reflux esophagitis: The general consensus”. The 39th Annual Con-ference of the Indian Society of Gastroenterology, Pune, India, Octo-ber 29–November 2, 1998.

180. “Asian perspectives of essential and non-essential peptic ulceration”. Alimentary Disease Week, Manila, November 22-25, 1998.

181. “Prospective double-blind randomized placebo-controlled study com-paring two Lansoprazole-based triple therapy and one dual therapy for H pylori (Hp)-related duodenal ulcer : an Asian multicenter study”. Alimentary Disease Week, Manila, November 22-25, 1998.

182. “Approach to dyspepsia in the new millennium”. Meeting on gas-troenterology, Macau, December 12-13, 1998.

183. “The role of H-pylori in functional dyspepsia”. Janssen-Cilag Congress on Innovation towards Better GI Care, Madrid, Spain, March 13-15, 1999.

184. “Acute pancreatitis”. Hong Kong Medical Forum, July 3-4, 1999.185. “A millenium of dyspepsia”, Beijing – Hong Kong Medical Forum, July

5, 1999.186. “Medical education at The University of Hong Kong: the philosophy

and implementation”. Beijing – Hong Kong Medical Forum, July 5, 1999.

187. “Gastric cancer – Where we now?” 9th Seah Cheng Siang Lecture in 19th Annual Combined Scientific Meeting, the Chapter of Physicians, Academy of Medicine, Singapore, July 24, 1999.

188. “Effect of H. pylori and NSAID on gastric mucosal inflammation”. In-augural Scientific Symposium of the Centre of Alimentary Research and Education (CARE), Hong Kong, September 17-19, 1999.

189. “Gastroenterology landmarks leading to the 21st century”. The Sixth Chinese National Congress of Gastroenterology, Xi’an, October 8-10, 1999.

190. “Functional Dyspepsia – 21st Century disease”. Indonesia National Congress of Gastroenterology, Jakarta, November 25-28, 1999.

191. “Prevalence of constipation, world-wide and Asia-Pacific”. Digestive Disease Week, Chiangmai, December 12-16, 1999.

192. “Helicobacter pylori and gastric cancer link”. Digestive Disease Week, Chiangmai, December 12-16, 1999.

193. “Hepatitis and liver disease history in Hong Kong”. APASL Commem-orative International Congress on Viral Hepatitis, Prevention and Con-trol, Singapore, February 16-19, 2000.

194. “Introduction & overview on acid-related disorders in Asia”. Asian Pa-cific Congress of Gastroenterology, Hong Kong, March 10-14, 2000.

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195. “Prevalence of constipation – Worldwide/Asia Pacific”. Asian Pacific Congress of Gastroenterology, Hong Kong, March 10-14, 2000.

196. “Dyspepsia: uninvestigated and functional”. Asian Pacific Congress of Gastroenterology, Hong Kong, March 10-14, 2000.

197. “Guidelines for therapy – a world perspective”. Helicobacter pylori: Basic mechanisms to clinical cure 2000, Bermuda, March 26-29, 2000.

198. “Guidelines for treatment of Helicobacter pylori infection – a world perspective”. International Conference on Life Science and Clinical Medicine, Beijing, April 19-21, 2000.

199. “Indications for H. pylori eradication”. The Third Western Pacific Heli-cobacter Congress, Bali, Indonesia, June 21-24, 2000.

200. “Immunological mechanisms for H. pylori induced gastric mucosal in-flammation”. The Third Western Pacific Helicobacter Congress, Bali, Indonesia, June 21-24, 2000.

201. “Diagnosis of H. pylori infection – how and in whom”. The Third West-ern Pacific Helicobacter Congress, Bali, Indonesia, June 21-24, 2000.

202. “The cellular and molecular basis for the prevention of gastric can-cer”. Plenary State-of-the-Art lecture in 2000 Shanghai International Conference of Gastroenterology, August 2-4, 2000.

203. “The cellular and molecular basis for the prevention of gastric can-cer”. Plenary lecture in Second World Conference on Digestology, Beijing, September 8-11, 2000.

204. “Updates & perspectives on H pylori guidelines worldwide – Asia/Aus-tralia”. Current concepts in the Management of Helicobacter pylori In-fection - Maastricht 2/2000, Maastricht, Amsterdam, September 21-22, 2000.

205. “Strategies in gastric cancer prevention”. Current concepts in the Management of Helicobacter pylori Infection - Maastricht 2/2000, Maastricht, Amsterdam, September 21-22, 2000.

206. “Helicobacter pylori and its management”. Advances in therapeutics course, The British Medical Association, Hong Kong, October 12, 2000.

207. “Cellular and molecular basis for the prevention of gastric cancer”. The 165th Anniversary Celebration Symposium of Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou, China, No-vember 5, 2000.

208. “Academic centres and the establishment phase”. The Drug Informa-tion Association (DIA) Meeting, Hong Kong, November 16-19, 2000.

209. “Practical issues in testing and treatment of Hp in the Asia-Pacific area”. GASTRO 2001, Annual Scientific Meeting of the Malaysian Soci-ety of Gastroenterology & Hepatology, Kota Kinabalu, Malaysia, April 5-8, 2001.

210. “Critical issues in H. pylori treatment”. GASTRO 2001, Annual Scien-tific Meeting of the Malaysian Society of Gastroenterology & Hepatol-ogy, Kota Kinabalu, Malaysia, April 5-8, 2001.

211. “Critical issues in H. pylori treatment”. Post-Hong Kong Medical Fo-rum Meeting, Nanjing, China, July 9-11, 2001.

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212. “Eradication of H. pylori: On-going trials to prevent gastric cancer or dysplasia”. XIV International Workshop on Gastroduodenal Pathology and H. pylori, Strasbourg, France, September 5-8, 2001.

213. “Better treatment of non-ulcer dyspepsia”. First Asian Pacific Diges-tive Week, Sydney, Australia, September 23-27, 2001.

214. “Prevention of gastric cancer – the directions forward”. The 2nd Con-gress of Digestive Disease Week, Shanghai, China, November 6-9, 2001.

215. “Cellular and Molecular Mechanisms for the Prevention of Gastric Cancer”. The Bockus Lecture, World Congress of Gastroenterology, Bangkok, February 24-March 1, 2002.

216. “Prevention of aspirin gastropathies and gastric cancer – where do we stand?”. The 5th Gastroenterology Symposium, Guangzhou, China, May 11-14, 2002.

217. “Biology and chemoprevention of gastric cancer." The G.B. Ong Lec-ture, Hong Kong Surgical Forum, Hong Kong, July 5-7, 2002.

218. “Cellular and Molecular Mechanisms for the Prevention of Gastric Cancer”. Post-Hong Kong Medical Forum Meeting, Kunming, China, July 8-10, 2002.

219. “H. pylori, Cancer and NSAID”. 中國醫學會第三屆全國 Hp 會議, Beijing, China, August 15-18, 2002.

220. “Pathogenesis of GERD: Acid and non-acid reflux, Gastric dysmotility, Nocturnal acid dysmotility”. Asia Pacific Consensus on GERD, Hon-olulu, November 8-9, 2002.

221. “Recent Understanding on the Relationship between NSAID and H.py-lori”. 11th Korean College of Helicobacter Research & Practice Confer-ence, Seoul, November 21, 2002.

222. “Biological Chemoprevention of Gastric Cancer”. 40th Korean Society of Gastroenterology Conference, Seoul, November 22,2002.

223. “The Okuda Lecture: The Role of Cyclo-oxygenase (COX) in GI dis-eases”. Asian Pacific Digestive Week, Singapore, September 27-30, 2003.

224. “Asia Pacific Consensus Meeting on GERD: Pathogenesis of GERD”. Asian Pacific Digestive Week, Singapore, September 27-30, 2003.

225. “Can our nation become gastric-cancer free?”. 6th National Confer-ence of Gastric Disease of China, Xiamen, March 5-7, 2004.

226. “Pathogenesis of Gastric Cancer”. 1st Beijing Digestive Disease Fo-rum, Beijing, June 17-20, 2004.

227. “Pathogenesis of gastric cancer – a unifying concept”. Oration, An-nual Scientific Meeting of the Malaysian Society of Gastroenterology & Hepatology, Penang, June 24-27, 2004.

228. “Interventional studies in GCA”. Annual Scientific Meeting of the Malaysian Society of Gastroenterology & Hepatology, Penang, June 24-27, 2004.

229. “Eradication of H. pylori and gastric cancer experience in Fujian Prov-ince, China”. Asian Pacific Digestive Week, Beijing, October 4-7, 2004.

230. “The Genes & Pathologies of the Gastric Cancer Assembly”. Asian Pa-cific Digestive Week, Beijing, October 4-7, 2004.

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231. “The Status and Perspective of Gastric Diseases in Asia”. Asian Pacific Digestive Week, Beijing, October 4-7, 2004.

232. “Pathogenesis of Gastric Cancer – A Unifying Concept”. Frontiers in Biomedical Research – Clinical Applications, Beijing, December 6, 2004.

233. “Epidemiology of GERD in the Asian Pacific Region”. 19th World Con-gress of International Society for Digestive Surgery, Yokohama, De-cember 8-11, 2004.

234. “Jiang Shao-Ji Lecture: Gastroesophageal Reflux Disease in the Asian Pacific-The Birth of a New Disease”. 5th Shanghai International Con-ference of Gastroenterology, Shanghai, July 7-9, 2005.

235. “Potential Biomarkers in New Drug Development”. World Congress of Gastroenterology, Montreal, September 12-14, 2005.

236. “Nanogastroenterology: the Way to Reinvent Ourselves”. Asian Pa-cific Digestive Week, Seoul, September 26-28, 2005.

237. State-of-the-Art Lecture on "Cox1, Cox2 and H. pylori-induced gastric inflammation”. 4th International Symposium on Cell/Tissue Injury and Cytoprotection /Organoprotection (Focus on GI Tract), Long Beach, May 17-19, 2006.

238. “Nanogastroenterology: the way to reinvent ourselves”. 3rd Beijing In-ternational Digestive Disease Forum, Beijing, May 27-29, 2006.

239. “Gastroesophageal Reflux Disease in Asian Pacific, a New Disease”. 15th World Congress of Pharmacology, Beijing, July 2-7, 2006.

240. “Recent Advance in Pathogenesis and Treatment of Gastroduodenal Diseases Associated with Helicobacter pylori Infection”. The 12th In-ternational Conference on Ulcer Research and GI Satellite of IUPHAR 2006, Osaka, July 7-9, 2006.

241. “Special Breakfast Lecture on “GERD in Asia Pacific region”. Seoul In-ternational Digestive Disease Symposium, Seoul, November 20-22, 2007.

242. “State-of-Art-Lecture on “Strategy for Prevention of Gastric Cancer”. Seoul International Digestive Disease Symposium, Seoul, November 20-22, 2007.

243. “H. pylori and Clarithromycin resistance in Asia”, Asia Pacific Consen-sus on Helicobacter pylori Infection, Bangkok, Thailand, June 14-15, 2008.

244. “The Next Gastroenterology of the Next Decade”, 6th Shanghai Inster-national Digestive Disease Conference, Shanghai, July 1-4, 2009.

CHAIRMANSHIP AT INTERNATIONAL AND OVERSEAS CONFERENCES (since 1995)

1. “Latest Advances in the Management of chronic hepatitis”. Interna-tional AGA/Singapore Gastroenterological Meeting, Singapore, 1995.

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2. “H pylori infection in South-East Asia & East Asia”. International AGA/Singapore Gastroenterological Meeting, Singapore, 1995.

3. “Neuro-vascular factors and defective mechanism”. Beijing Interna-tional Symposium on Peptic Ulcer, Beijing, 1995.

4. “Prostaglandins, Nitric Oxide and Microcirculation”. 6th Taisho Inter-national Symposium on Gastroenterology, Shimoda, 1996.

5. “Inflammatory Bowel Diseases”. 1996 Shanghai International Confer-ence of Gastroenterology, Shanghai, 1996.

6. “H pylori - clinical and treatment”. 7th Taisho International Sympo-sium on Gastroenterology, Washington, 1997.

7. “Advances of Clinical Trials on H. pylori”. International Symposium on Inflammation and Mucosal Injury, Hawaii 1997.

8. Scientific Session: Transplantation. International Symposium on Hep-atology, Beijing 1997.

9. Scientific Session: Prize Presentation for Young Investigators. Interna-tional Symposium on Hepatology, Beijing 1997.

10. Takada Symposium on “Helicobacter pylori and inflammation”. Xth International Workshop on Gastroduodenal Pathology and Helicobac-ter pylori, Lisbon, 1997.

11. Plenary Session: Reflux Disease and its impact on patients. Reflux Disease Management - The Genval Workshop, Belgium, 1997.

12. Discussion subgroup: Diagnosis - symptom assessment and roles of investigations. Reflux Disease Management - The Genval Workshop, Belgium, 1997.

13. “Highlights and commentary on the Asia Pacific consensus statement on H pylori”. The 2nd Western Pacific Congress of Helicobacter pylori, Kota Kinabalu, Malaysia, June 25-27, 1998.

14. Cheng Si Yuan Lecture: Pathogenesis of flares in chronic hepatitis B. Inauguration Ceremony of Cheng Si Yuan (China-International) Hep-atitis Research Foundation, Hong Kong, August 15-16, 1998.

15. “Quadrennial review treatment of hepatocellular carcinoma”. World Congress of Gastroenterology, Vienna, September 6-11, 1998.

16. Plenary Session “Epidemiology & prevention of gastrointestinal & hepatobiliary cancer”. World Congress of Gastroenterology, Vienna, September 6-11, 1998.

17. Plenary Session “The Disease Pattern Day: Workshop – Drug regula-tions & development”. Asian Clinical Trials Conference 1998, Hong Kong, October 25-27, 1998.

18. “The role of H-pylori in functional dyspepsia”. Janssen-Cilag Congress on Innovation towards Beter GI Care, Madrid, Spain, March 13-15, 1999.

19. “Functional dyspepsia – a non-disorder?” Working group, Janssen-Cilag Congress on Innovation towards Better GI Care, Madrid, Spain, March 13-15, 1999.

20. “Current treatment of gastrointestinal and liver cancers: What can you tell your patients and what’s the family physicians’ role?” 15th

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Annual Scientific Meeting of Gastroenterological Society of Singapore, in conjunction with the 19th Annual Scientific Meeting of the Chapter of Physicians, Academy of Medicine, Singapore, July 24-25, 1999.

21. “H. pylori and NSAIDs: partners in crime or a strategic alliance?” In-augural Scientific Symposium of the Centre of Alimentary Research and Education (CARE), Hong Kong, September 17-19, 1999.

22. “Overview of NSAIDs” Inaugural Scientific Symposium of the Centre of Alimentary Research and Education (CARE), Hong Kong, Septem-ber 17-19, 1999.

23. “Overview lecture on Nitric Oxide” Inaugural Scientific Symposium of the Centre of Alimentary Research and Education (CARE), Hong Kong, September 17-19, 1999.

24. “NSAID-Gastropathy: Clinical aspects” Inaugural Scientific Sympo-sium of the Centre of Alimentary Research and Education (CARE), Hong Kong, September 17-19, 1999.

25. “Nitric oxide to counter NSAID-Gastropathy: a little goes a long way!” Inaugural Scientific Symposium of the Centre of Alimentary Research and Education (CARE), Hong Kong, September 17-19, 1999.

26. “Review of a clinical development of Celecoxib, a specific COX-2 in-hibitor: classification and clinical evidence for improved GI safety over NSAIDs” Inaugural Scientific Symposium of the Centre of Alimen-tary Research and Education (CARE), Hong Kong, September 17-19, 1999.

27. “Will COX-2 inhibitors make NSAID gastropathy a thing of the past?” Inaugural Scientific Symposium of the Centre of Alimentary Research and Education (CARE), Hong Kong, September 17-19, 1999.

28. Editors’ Meeting of the Journal of Gastroenterology & Hepatology held during Digestive Disease Week (in my capacity as its Chief Editor), December 11-12, 1999.

29. “Non-Steroidal Anti-Inflammatory Drugs”. Digestive Disease Week, Chiangmai, December 12-16, 1999.

30. “Support for immunisation programmes”. APASL Commemorative In-ternational Congress on Viral Hepatitis, Prevention and Control, Sin-gapore, February 16-19, 2000.

31. “Nitric oxide and gastrointestinal diseases”. Nobel Prize Laureate Special Lecture. Asian Pacific Congress of Gastroenterology, Hong Kong, March 10-14, 2000.

32. “From cytokines to growth factors”. CARE Symposium. Asian Pacific Congress of Gastroenterology, Hong Kong, March 10-14, 2000.

33. “Functional gastric disturbances in Helicobacter pylori infection”. He-licobacter pylori: Basic mechanisms to clinical cure 2000, Bermuda, March 26-29, 2000.

34. Symposium on “gastric cancer”. 2000 Shanghai International Confer-ence of Gastroenterology, August 2-4, 2000.

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35. APAGE Vision, Mission & Strategic Retreat (organized as new Presi-dent of Asian Pacific Association of Gastroenterology), Hangzhou, Au-gust 5-7, 2000.

36. Plenary consensus workshop on “Prevention of gastric cancer and other H pylori related pathologies”. Current concepts in the Manage-ment of Helicobacter pylori Infection - Maastricht 2/2000, Maastricht, Amsterdam, September 21-22, 2000.

37. Millennium Lecture (1) in Liver Diseases in the New Millennium, Shanghai, September 23-26, 2000.

38. “Asian-Pacific Consensus on viral hepatitis: China perspectives”. Liver Diseases in the New Millennium, Shanghai, September 23-26, 2000.

39. “Hepatology”. Hong Kong College of Physicians Joint Scientific Meet-ing – Medicine: East Meets West, Hong Kong, October 14-15, 2000.

40. “Asian clinical trials”. The Drug Information Association (DIA) Meet-ing, Hong Kong, November 16-19, 2000.

41. “Gastrointestinal Cancer in the Region”. First Asian Pacific Digestive Week, Sydney, Australia, September 23-27, 2001.

42. “Update on H. pylori”. First Asian Pacific Digestive Week, Sydney, Australia, September 23-27, 2001.

43. Plenary Session 3(b) on “Development of Traditional Chinese Medicine in the U.S.A.”, “Pathogenesis and Treatment of Primary Sclerosing Cholangitis” and “Molecular Mechanism of Cholestasis”, The 3rd International Symposium on Hepatology, Hangzhou, China, October 18-23, 2001.

44. “OMGE Symposium on GI Cancer”. The 2nd Congress of Digestive Dis-ease Week, Shanghai, China, November 6-9, 2001.

45. Janssen Satellite Symposium on “The Art of GERD Treatment: Evolu-tion towards Perfection”. The World Congress of Gastroenterology, Bangkok, Thailand, February 24-March 1, 2002.

46. “Evening Symposium I (Eisai)”. Asian Pacific Digestive Week, Singa-pore, September 27-30, 2003.

47. “Presidential Paper Oral Presentation”. Asian Pacific Digestive Week, Singapore, September 27-30, 2003.

48. “Young Investigator’s Award Presentation”. Asian Pacific Digestive Week, Singapore, September 27-30, 2003.

49. “Asian Pacific Working Party Meeting on Inflammatory Bowel Dis-ease”. Asian Pacific Digestive Week, Beijing, October 4-7, 2004.

50. “Presidential Paper Awards”. Asian Pacific Digestive Week, Beijing, October 4-7, 2004.

51. “GERD and Barrett’s Esophagus”. 5th Shanghai International Confer-ence of Gastroenterology, Shanghai, July 7-9, 2005.

52. “Symposium on IBS”. 5th Shanghai International Conference of Gas-troenterology, Shanghai, July 7-9, 2005.

53. “H. pylori and Upper Gastrointestinal Symptoms”. World Congress of Gastroenterology, Montreal, September 12-14, 2005.

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54. “Cheng Si Yuan Memorial Lecture”. Shanghai-HK Int’l Liver Congress, Shanghai, March 25-28, 2006.

55. “Stem Cells and Tissue Regeneration”. 4th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection (Focus on GI Tract), Long Beach, May 17-19, 2006.

56. “Helicobacter pylori-Clinical”. The 12th International Conference on Ul-cer Research and GI Satellite of IUPHAR 2006, Osaka, July 7-9, 2006.

57. “Special Lecture GI: Innate Immunity and Inflammation”. Asian Pa-cific Digestive Week 2007, Kobe, October 15-18, 2007.

58. “Special Lecture on The Flood of Endoscopic Innovations: Hits or Misses?”. Seoul International Digestive Disease Symposium, Seoul, November 20-22, 2007.

59. “Special Lecture on Identication and Clinical Applications of MGAgs Novel Tumor Antigens Associated with Gastric Cancer”. Seoul Interna-tional Digestive Disease Symposium, Seoul, November 20-22, 2007.

PROFESSIONAL AND INTERNATIONAL NETWORK

Hong Kong

Good network of medical alumni and colleagues (teacher of over 4000 doctors).

Good number of philanthropic patients. Family physician to Mr. C. H. Tung, Chief Executive HKSAR, and Mrs.

Betty Tung.

China

Vigorous networking since China opened up following the cultural revolution.

Establlished the China Ulcer Research Group in the 6 geographical re-gions of China.

Received a sizeable number of trainees through the years from vari-ous parts of China, and they form a fine network among themselves.

Organized large-scale (>1000 participants) international conferences jointly with Chinese institutions in Beijing, Shanghai, Chengdu, and Hong Kong, at the request of the Chinese Minister of Health, two-

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yearly until 1997, when China became ready to organize its own in-ternational conference.

Conducted a population-based longitudinal study on chemopreven-tion of gastric cancer in Changle, Fujian, where an endoscopic survey was performed in 1994 and 1999. Started another in 2002 in Shan-dong. Through these projects, a national network of professionals on healthcare and public health on stomach cancer was built.

Established the Cheng Si Yuan (China-International) Hepatitis Re-search Foundation in 1998, and organized two international hepatitis conferences in Shenzhen and Shanghai (attendance 1,300). Signed an agreement with The Chinese Foundation for Hepatitis Prevention to conduct a hepatitis vaccination programme for the poor children in Western China, beginning at end of 2001.

Academic collaboration with Mr. Wu Jie-ping, Mr. Cheng Si Yuan, and Madam He Laoli, all being Vice-Chairman of the Standing Committee of the Chinese People’s Congress, with Mr Zhang Wen-Kang, Chinese Minister of Health, and with most major medical institutions in China.

Guest professor in 5 medical institutions.

Asia

Wide network in the region, as the elected President of the Asian Pa-cific Association of Gastroenterology, a position achieved through in-tense collaborative efforts with the professional bodies and medical institutions in the region.

Visiting professor, visiting specialist, keynote speaker, collaborator in research and conferencing in Australian and New Zealand universities and medical associations.

External examiner and keynote speakers in Singapore, Malaysia, Thailand, Phillipines, Indonesia, India, Pakistan, Korea and Japan, and principal investigator in a number of collaborative research projects in Asia.

Fast becoming, unfurtunately, a fatherly figure in gastroenterology in Asia.

International

Widely connected with the international arena, ss founding editor of one international journal (J Gastroenterol Hepatol, 1986) and having served on the editorial board of over 20 internaitonal journals.

Committee member and chair of a good number of international pro-fessional organizations including OMGE (World Organization of Gas-troenterology), in Europe and North America. Keynote speaker on

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many international and national meetings in these two continents, as well as in Australia, Brazil and South Africa.

Historical and traditional networking with the colleges of physicians of UK and Australia.

Developed a close network of medical deans of Universitas 21 through hosting a dean’s conference in Hong Kong in 2002.

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PUBLICATIONS

M.D. Thesis

Lam SK. Clinical and pathophysiological studies on duodenal ulceration: evidence for the existence of two populations, 1975.

Papers in Peer-Reviewed Journals

1. So P.L., Chan T.K., Lam S.K., Teng C.S., Yeung R.T.T., Todd D. Cortisol metabolism of glucose-6-phosphate dehydrogenase deficiency. Me-tabolism 1973;22:1443-8.

2. Lam S.K. , Sircus W. Studies on duodenal ulcer I. The clinical evi-dence for the existence of two populations. Quart JM 1975;44:369-387.

3. Lam S.K. , Sircus W. Vagal hyperactivity in duodenal ulcers: with and without acid hypersecretion. Rend Di Gastroenterol1975;7:5-8.

4. Lam S.K. , Sircus W. A comparison of the acid and gastrin secretory response to hypoglycaemia and meals in duodenal ulcer with and without acid hypersecretion to pentagastrin. Digestion 1976;14:1-11.

5. Lam S.K. , Lai C.L. Inhibition of sulpiride on the cephalic phase of gas-tric acid and gastrin secretion in duodenal ulcer patients. Scand J Gastroenterol 1976;11:27-31.

6. Byrnes D.J., Lam S.K., Sircus W. The relation between functioning parietal cell and gastrin cell masses in two groups of duodenal ulcer patients. Clin Sci Mol Med 1976;50:375-383.

7. Findlay J., Lam S.K., Byrnes D.J., Sircus W., McManus J.P.A. Relation-ship between the functional parietal and gastrin cell masses before and after gastric irradiation. In: Lee SK, Sinniah R, Tan LKA, Phua KB, Chow KW, eds. 5th Asian Pacific Congress Of Gastroenterology, Sin-gapore: 1976:842-5.

8. Lam S.K. , Lam W.K., Cheng F.C.Y., Ong G.B. Transabdominal suture of bleeding gastro-oesophageal varices in cryptogenic cirrhosis of the liver. In: Lee SK, Sinniah R, Tan LKA, Phua KB, Chow KW, eds. 5th Asian Pacific Congress Of Gastroenterology. Singapore: Stanford Col-lege Press, 1976:545-51.

9. Lam S.K. , Lai C.L. Effect of sulpiride on the cephalic phase of gastric acid and gastrin secretion in duodenal ulcer patients. In: Lee SK, Sin-niah R, Tan LKA, Phua KB, Chow KW, eds, 5th Asian Pacific Congress Of Gastroenterology, Singapore: Stanford College Press, 1976:825-30.

10. Lam S.K. , Ong G.B. Duodenal ulcers: early and late onset. Gut 1976;7:169-179.

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11. Prescott R.J., Sircus W., Lai C.L., Lam S.K. Failure to confirm evidence for existence of two populations with duodenal ulcer. Brit Med J 1976;2:677.

12. Lam S.K. Hypergastrinaemia in cirrhosis of liver. Gut 1976;17:700-708.

13. Lam S.K. , Sircus W., Byrnes D.J. Is reduced release of gastrin the mechanism of ucler healing after gastroenterotomy. Am J Dig Dis 1977;22:397-401.

14. Lam S.K. , Sircus W. Cholinergic inhibition and release of gastrin fol-lowing insulin injection in duodenal ulcer before operation and afer complete and incomplete vagotomy. Am J Dig Dis 1977;22:214-222.

15. Lam S.K. , Lam W.K., Cheng F.C.Y., Ong G.B. Transabdominal suture of bleeding gastro-oesophageal varices in cryptogenic cirrhosis of the liver. Brit J Surg 1977;64:428-432.

16. Lam S.K. , Sircus W. Cholinergic suppression of the acid response to pentagastrin in normosecreting and hypersecreting duodenal ulcer patients. Rend Di Gastroenterol 1977;9:9-12.

17. Cheng F.C.Y., Lam S.K., Ong G.B. Maximum acid output to graded doses of pentagastrin and its relation to parietal cell mass in Chinese patients with duodenal ulcer. Gut 1977;18:827-832.

18. Lam S.K. , Tsui J.K.C., Chan P.K.W., Wong K.P., Ong G.B. How often does bacteraemia occur after endoscopic retrograde cholangiopan-creatography (ERCP)? Endoscopy 1977;9:231-234.

19. Lam S.K. , Wong K.P., Chan P.K.W., Ngan H., Todd D., Ong G.B. Fatal cholangitis after endoscopic retrograde cholangiopancreatography (ERCP) in congenital hepatic fibrosis. Aust N Zeal J Surg 1978;48:199-202.

20. Lam S.K. , Chan P.K.W., Cheng F.C.Y., Ong G.B. The inter-relationship between bleeding, perforation and stenosis in duodenal ulceration. Aust N Zeal J Surg 1978;4:152-155.

21. Lam S.K. , Wong K.P., Chan P.K.W., Ngan H., Ong G.B. Recurrent pyo-genic cholangitis: a study by endoscopic retrograde cholangiography. Gastroenterology, 1978;74:1196-1203.

22. Lam S.K. , Lai C.L. Gastric ulcers with and without associated duode-nal ulcer have different pathophysiology. Clin Sci Mol Med 1978;55:97-102.

23. Lam K.C., Lai C.L., Lam S.K., Lin H.J., Kwan Y.L. Isoprenosine in classi-cal acute viral hepatitis. Am J Dig Dis 1978;23:893-896.

24. Lam S.K. , Chan P.K.W., Wong J., Ong G.B. Fasting and postprandial gastrin before and after highly selective vagotomy, truncal vagotomy and pyloroplasty and truncal vagotomy with antrectomy - is there a cholinergic antral gastrin inhibitory and releasing mechanism? Brit J Surg 1978;65:797-800.

25. Cheng F.C.Y., Chan P.K.W., Wong J., Lam S.K., Ong G.B. Experience in shunting operations fo portal hypertension in cirrhosis of liver in Hong Kong. J Asso Surg Southeast Asia 1978;1:12.

56


26. Lam K.H., Lim S.T.K., Lam S.K., Wong J., Ong G.B. Gastric histology and function in patients with intrathoracic stomach replacement after oesophagectomy. Brit J Surg 1979;85:283-290.

27. Lam S.K. , Lam K.C., Lai C.L., Yeung C.K., Yam L.Y.C., Wong W.S. Treatment of duodenal ulcer with antacid and sulpiride - A double blind controlled study. Gastroenterology 1979; 76: 315-322.

28. Ong G.B., Lam K.H., Lam S.K., Lim S.T.K., Wong J. Acute pancreatitis in Hong Kong. Brit J Surg 1979;66:398-403.

29. Lam S.K. , Isenberg J.I., Grossman M.I., Lane W.H., Walsh J.H. Gastric acid secretion is abnormally sensitive to endogenous gastrin released after peptone test meals in duodenal ulcer patients. J Clin Invest 1980;65:555-562.

30. Wong J., Lam S.K., Lee N.W., Lai C.L., Lam P., Ong G.B. Immediate operation for acute non-variceal gastrointestinal haemorrhage in pa-tients aged 50 years and over. Aust N Zeal J Surg 1980;50:150-154.

31. Lam S.K. , Hasan M., Sircus W., Wong J., Ong G.B., Prescott R.J. A comparison of the maximal acid output and gastrin response to meals in Chinese and Scotts, normals and with duodenal ulcer. Gut 1980;21: 324-328.

32. Lam S.K. , Ong G.B. Relationship of postprandial serum gastrin re-sponse to sex, body weight, blood group status, familial dyspepsia, duration and age of onset of ulcer symptoms in duodenal ulcer. Gut 1980;21:528-532.

33. Lam S.K. Peptic ucler and its management with special reference to Southeast Asia. Med Progress 1980;7:13-23.

34. Prescott R.J., Lam S.K., Hasan M., Sircus W., Wong J., Ong G.B. The relationship between body parameters and gastric acid secretion in normal controls and duodenal ulcer subjects in two ethnic groups. Ital J Gastroenterol 1980;12:167-170.

35. Lam S.K. , Ong G.B. Identification of two subgroups of familial early onset duodenal ulcers. Ann Intern Med 1980;93:540-544.

36. Koo J., Ho J.C.I., Lam S.K., Wong J., Ong G.B. Colloidal bismuth in the treatment of experimental gastric ulcer: mechanism of action. 1: His-tochemical study. In: Umehara S, Ito H eds Advances In Experimen-tal Ulcers, 4th International Conference, Tokyo 1980:586-8.

37. Tsang R.S.W., Chau P.Y., Lam S.K., LaBrooy J.T., Rowley D. Antibody response to the lipopolysaccharide and protein antigens of Salmo-nella typhi during typhoid infection: measurement of serum anti bod-ies by radioimmunoassay. Clin Exper Immunol 1982;46:508-514.

38. Chau P.Y., Tsang R.S.W., Lam S.K., LaBrooy J.T., Rowley D. Antibody response to the lipopolysaccharide and protein antigens of Salmo-nella typhi during typhoid infection: measurement of intestinal anti-bodies by radioimmunoassay. Clin Exper Immunol 1982;46:515-520.

39. Lam S.K. Vagotomy vs H2 receptor antagonists in ulcers: long term effects, Med Progress, editorial 1981;8:68-9.

40. Lam S.K. An approach to jaundice. Hong Kong Practitioner 1981; 3: 343-9.

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41. Lim S.T.K., Lam S.K., Lee N.W., Wong J., Ong G.B. Gastric acid secre-tion and serum gastrin levels in Chinese patients with chronic renal failure. Proceedings of the Fourth Colloquim In Nephrology, Asian-Pa-cific, 1981.

42. Lam S.K. Sucralfate: a promising new treatment of peptic ulcer. Med Progress, editorial 1982;9:11-2.

43. Lam S.K. Is pseudomembranous colitis infectious. Med Progress, edi-torial 1982;9:66-7.

44. Koo J., Lam S.K., Ong G.B. Cimetidine versus Surgery for recurrent ul-cer after gastric surgery. Ann Surg 1982;195: 406-12.

45. Koo J., Ho J., Lam S.K., Ong G.B. Selective coating of gastric ulcer by tripotassium dicitrato bismuthate in the rat. Gastroenterology 1982; 82: 864-70.

46. Lam S.K. , Isenberg J.I., Grossman M.I., Hogan D., Lane W.H. Rapid gastric emptying in duodenal ulcer patients. Dig Dis & Sci 1982; 27: 598-604.

47. Lam S.K. Corticosteroid therapy in chronic active hepatitis. Med Progress, 1982; 9: 8-9.

48. Koo J., Ngan Y.K., Lam S.K. Trends in hospital admission, perforation and mortality of peptic ulcer in Hong Kong from 1970-1980. Gas-troenterology 1982, 84:1558-1562.

49. Lam S.K. Sulphasalazine retention enemas in ulcerative colitis. Med Progress 1982;9:49, editorial.

50. Lam S.K. , Hui K.K., Ho J., Wong K.P., Rotters J.I., Samloff M.I. Pachy-dermoperiostosis, hypertrophic gastropathy, and peptic ulcer. Gas-troenterology 1983;84:834-9.

51. Lim S.T.K., Lam S.K., Lee N.W., Wong J., Ong G.B. Effects of gastro-cystoplasty on serum gastrin levels and gastric acid secretion. Brit J Surg 1983;70:275-277.

52. Lam S.K. Amoebiasis. Therapeia 1983;Suppl:9-10.53. Lam S.K. , Koo J. Accurate prediction of duodenal-ulcer healing rate

by discriminant analysis. Gastroenterology 1983;85:403-412.54. Koo J., Lam S.K. Individual prediction of ulcer recurrence after vago-

tomy for chronic duodenal ulcer by discriminant analysis. Gastroen-terology 1983;85:413-9.

55. Lam S.K. , Koo J., Sircus W. Early and late onset duodenal ulcers in Chinese and Scots. Scand J Gastroenterol 1983;18:651-8.

56. Koo J., Lam S.K., Chan P., Lee N.W., Lam P., Wong J., Ong G.B. Proxi-mal gastric vagotomy, truncal vagotomy and drainage, and truncal vagotomy and antrectomy for chronic duodenal ulcer. A prospective, randomized controlled trial. Ann Surg 1983;197:265-71.

57. Koo J., Lam S.K., Ong G.B. Recurrent ulcer treated with colloidal bis-muth. Med J Aust 1983;1:103-4.

58. Koo J., Lam S.K., Boey J., Lee N.W. Gastric acid secretion and its pre-dictive value after vagotomy for perforated duodenal ucler. Scand J Gastroenterol 1983;18:929-34.

59. Lam S.K. The peptic ulcer problem in South-East Asia. Med Progress, 1983;special issue:59-68.

58


60. Lam S.K. A study of endoscopic sphincterotomy in recurrent pyo-genic cholangitis. Brit J Surg 1984;71:262-6.

61. Lam S.K. , Lee N.W., Koo J., Hui W.M., Fok K.H., Ng M. A randomized cross-over trial of tripotassium dicitrato bismuthate versus high dose cimetidine for duodenal ulcers resistant to standard dose of cimeti-dine. Gut, 1984;25:703-6.

62. Lam S.K. Mebendazole in human echinococcosis. Med Progress 1984;11:54-55.

63. Kumana C.R., Lam S.K. Role of H2 antagonists in the treatment and prevention of duodenal and gastric ulceration. Hong Kong Practi-tioner 1985;7:1291-4.

64. Murakami M., Lam S.K., Inada M., Miyake T. Pathophysiology and pathogenesis of acute gastric mucosal lesions following hypothermic restraint stress in rats. Gastroenterology 1985; 88: 660-5.

65. Lam S.K. Use of cytoprotective agents in the treatment of gastric ul-cers. Med J Aust 1985;142:S21-23.

66. Lam S.K. , Lai C.L., Lee L.N.W., Fok K.H., Ng M.M.T., Siu K.F. Factors influencing healing of duodenal ulcer. Control of nocturnal secretion by H2 blockade and characteristics of patients who failed to heal. Dig Dis & Sci 1985;30:45-51.

67. Lam S.K. , Koo J. Gastrin sensitivity in duodenal ulcer. Gut 1985;26:485-90.

68. Lam S.K. , Lai C.L., Ng M.M.T., Fok K.H., Hui W.M. Duodenal ulcer healing by separate reduction of postprandial and nocturnal acid se-cretions have different pathophysiology. Gut 1985;26:1038-44.

69. Lam S.K. , Lau W.Y., Lai C.L., Lee N.W., Poon G.P., Hui W.M., Lok A., Ng M.M.T., Fok K.H., Yu H.C. Efficacy of sucralfate in corpus, prepyloric, and duodenal-ulcer associated gastric ulcers. A double-blind, placebo- controlled study. Am J Med 1985;79(2C):24-31.

70. Lam S.K. , Chan C.W. Pyogenic cholangitis recent aetiology and man-agement. Survey Dig Dis 1985;3:12-24.

71. Lok A.S.F., Lai C.L., Lam S.K. HBsAg positive: What to do? Med Progress 1985, 12:7-10.

72. Lam S.K. , Okuda K,. Piper D., Powell L.W., Shearman D.J.C., Seah C.S. Founding editorial. J Gastroenterol Hepatol 1986;1:1-2.

73. Ho J., Lui I., Hui W.M., Ng M.T.T., Lam S.K. A study of the correlation of duodenal-ulcer healing with campylobacter-like organisms. J Gas-troenterol Hepatol 1986;l:69-74.

74. Lam S.K. Cytoprotective agents in gastric disorders. World Thera-peutic Digest 1986;1:2-4.

75. Hui W.M, Lam S.K., Ho J., Ng M.T.T., Lui I., Lai C.L., Lok A., Lau W.Y., Poon G.P., Choi S., Choi T.K. Chronic antral gastritis in duodenal ucler - natural history and treatment with prostaglandin E . Gastroenterol-ogy 1986;91:1095-1101.

76. Lam S.K. , Lau W.Y., Choi T.K., Lai C.L., Lok A.S.F., Hui W.M., Ng M.M.T., Choi S.K.Y. Prostaglandin E1 (misoprostol) overcomes the ad-verse effect of chronic cigarette smoking on duodenal-ulcer healing. Dig Dis & SciS 1986;31:68S-74S.

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77. Lam S.K. , Wong H., Ng M.M.T. Hypersomatostatinaemia in duodenal ulcer. J Gastroenterol Hepatol 1986;1:119-127.

78. Lok A.S.F., Wong K.P., Lee P.K., Chiu K.W., Mok C.K., Lam S.K. Radio-logical diagnosis of leiomosarcoma of inferior vena cava. Clin Radiol 1986;37:403-5.

79. Lam S.K. Prostaglandins for duodenal ulcer and gastric ulcer. J Gas-troenterol Hepatol 1986;1:471-481.

80. Hui W.M., Lam S.K., Lok A.S.F., Ng M.T.T., Wong K.L., Fok K.H. Sulpiride imporves functional dyspepsia - a double blind controlled study. J Gastroenterol Hepatol 1986;1:391-9.

81. Lam S.K. Cytoprotective agents come of age. World Therapeutic Di-gest 1986;1:2-4.

82. Lam S.K. An update on peptic ulcer treatment: the short and long term efficacy of cytoprotective and site-protective agents in ulcer healing is indistinguishable from that of H2-receptor antagonists. Med Progress, 1987;27-34.

83. Lam S.K. , Hui W.M. Stress ulcer syndrome. G.I. Futures 1987;2:4-10.84. Lam S.K. , Hui W.M., Lam W.Y., Branicki F.J., Lai C.L., Lok A.S.F., Ng

M.T.T., Fok P.J., Poon G.P., Choi T.K. Sucralfate overcomes adverse effect of cigarette smoking on duodenal ulcer healing and prolongs subsequent remission. Gastroenterology 1987;92:1193-1201.

85. Hui W.M., Lam S.K. Multiple duodenal ulcer: natural history and pathophysiology. Gut 1987;28:1134-41.

86. Lam S.K. Prostaglandins for duodenal ulcer. Clinical Investigative Medicine, 1987;10:232-7.

87. Lam K.S.L, Yeung R.T.T., Ho P.W.M., Lam S.K. Glucose intolerance in thyrotoxicosis - roles of insulin, glucagon and somatostatin. Acta En-docrinologica 1987;114:228-34.

88. Hui W.M., Liu H.C., Lam S.K., Koo A. Histamine containing cells in gastric fundus of dogs. Cell Mol Biol 1987;33:747-54.

89. Hui W.M., Lam S.K., Chau P.Y., Ho J., Lau W.Y., Poon K.P., Lai C.L., Lok A.S.F., Lui I.O.L., Ng M.M.T. Pathogenetic role of Campylobacter py-loridis in gastric ulcer. J Gastroenterol Hepatol 1987;2:309-16.

90. Hui W.M., Lam S.K., Chau P.Y., Ho J., Lui I., Lai C.L., Lok A.S.F., Ng M.M.T. Persistence of Campylobacter pyloridis despite healing of duodenal ulcer and improvement of accompanying duodenitis and gastritis. Dig Dis Sci 1987;32:1255-60.

91. Koo J., Lam S.K. Discriminant factors of gastric ulcer healing by col-loidal bismuth. J Gastroenterol Hepatol 1987;2:473-83.

92. Hui W.M., Liu H.C., Lam S.K. Enterochromaffin-like cells of the human stomach - demonstration of histamine content and cholinergic nerve supply. Cell Mol Biol 1988;34:303-309.

93. Hui W.M., Lam S.K. Monthly variation in frequency of active duodenal ulcer and maximal acid output. J Gastroenterol Hepatol 1988;3:457-63.

94. Lam S.K. , Piper D.W. Geographical variations in peptic ulcer. J Gas-troenterol Hepatol 1988;3:399-401.

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95. Feldman M., Richardson C.T., Lam S.K., Samloff I.M. Comparison of gastric acid secretion rates and serum pepsinogen I and II concentra-tions in occidental and oriental duodenal ulcer patients. Gastroen-terology 1988;95:630-5.

96. Hui W.M., Lam S.K. Etiology and management of chronic gastritis. Dig Dis 1989;7:51-60.

97. Hui W.M., Lam S.K. Perforated peptic ulcer. Med Progress 1989;16:12-16

98. Lam S.K. , Hui W.M. Stress ulcer bleeding in the critically ill. J of Gas-troenterol & Hepatol 1989 Suppl.1,27-35.

99. Ho J., Hui W.M., Ng I., Lam S.K. Natural history of Campylobacter py-lori in duodenal ulceration treated with an H2-antagonist. Aliment Pharm Therap 1989;3:315-20.

100. Branicki F.J., Coleman S.Y., Pritchett C.J., Cheung W.L., Tuen H.H., Fok P.J., Fan S.T., Lai E.C.S., Lau P.W.K., Mok F.P.T., Lam S.K., Hui W.M., Lam D.K.H., Tang A.P.K., Tse M.C.K., Wong J. Bleeding duodenal ul-cer: risk models and mortality for emergency surgery. J Hong Kong Med Asso 1989;41:320-325.

101. Hui W.M., Liu H.C., Lam S.K. Parietal cells in duodenal ulcer disease: a histochemical study of the effects of omeprazole and ranitidine on mitochondrial activities. J Gastroenterol Hepatol 1989;4:143-149.

102. Domschke W., Lam S.K., Pounder R.E., Andersen D. H2-Blocker-resis-tant duodenal ulceration. Gastroenterology International 1989;2:85-91.

103. Hui W.M., Lam S.K., Ho J., Ng I., Lau W.Y., Branicki F.J., Lai C.L., Lok A.S.F., Ng M.M.T., Fok P.J., Poon G.P., Choi T.K. The effect of sucral-fate and cimetidine on duodenal ulcer associated antral gastritis and campylobacter pylori. Am J Med 1989;86(6A):60-5.

104. Lam S.K. Implications of sucralfate induced ulcer healing and re-lapse. Am J Med 1989;86(6A):122-6.

105. Hui W.M., Lam S.K., Lau W.Y., Branicki F.J., Lok A.S.F., Ng M.M.T., Lai C.L., Poon G.P. Omeprazole and ranitidine in duodenal ulcer healing and subsequent relapse - a randomized double-bllind study with weekly endoscopic assessment. J Gastroenterol Hepatol 1989;4 (Suppl 2):35-43.

106. Chen B.W., Hui W.M., Lam S.K., Cho C.H., Ng M.M.T., Luk C.T. Effect of sucralfate on gastric mucosal blood flow in rats. Gut 1989;30:1544-51.

107. Branicki F.J., Coleman S.Y., Pritchett C.J., Cheung W.L., Tuen H.H., Fok P.J., Fan S.T., Lai E.C.S., Lau P.W.K., Mok F.P.T., Lam S.K., Hui W.M., Lam D.K.H., Tang A.P.K., Tse M.C.K., Wong J. Bleeding duodenal ul-cer: risk models and mortality for emergency surgery. J Hong Kong Med Asso 1989;41:320-325.

108. Lam S.K. , Hui W.M., Ng M.M.T., Lok A.S.F., Lai C.L., Branicki F., Lau W.Y., Poon G.P. Reducing meal-stimulated acid secretion versus re-ducing nocturnal acid secretion for the healing of duodenal ulcer. Dig Dis & SciS 1989;34:1494-1500.

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109. Hui W.M., Lam S.K. Non-ulcer dyspepsia. Aetiology and manage-ment. Med Progress 1989 Sept:25-32.

110. Cho C.H., Chen B.W., Poon Y.K., Ng M.M.T., Hui W.M., Lam S.K., Ogle C.W. Dual effects of zinc sulphate on ethanol-induced gastric injury in rats: possibly mediated by an action on mucosal blood flow. J Phar-macol 1989;41:685-689.

111. Branicki FJ, Coleman SY, Lau PWK, Pritchett CJ, Cheung WL, Tuen HH, Lam SK, Hui WM, Tse MCK, Lam DKH, Wong J. Upper Gastrointestinal rebleeding: a risk model for mortality. Asian J of Surgery, 1989;41:320-325.

112. Branicki F.J., Coleman S.Y., Fok P.J., Pritchett C.J., Fan S.T., Lai W.C.S., Mok F.P.T., Cheung W.L., Lau P.W.K., Tuen H.H., Lam S.K., Hui W.M., Ng M.M.T., Lam D.K.H., Tse M.C.K., Tang A.P.K., Wong J. Bleeding peptic ulcer: a prospective evaluation of risk factors for rebleeding and mortality. World J Surg 1990;14:262-270.

113. Branicki F.J., Boey J., Fok P.J., Pritchett C.J., Fan S.T., Lai E.C.S., Mok F.P.T., Wong W.S., Lam S.K., Hui WM, Ng MMT, Lok ASF, Lam DKH, Tse MCK, Tang APK, Wong J. Bleeding duodenal ulcer. A prospective evaluation of risk factors for rebleeding and death. Ann Surg 1990;211:411-418.

114. Lam SK . Prevention and management of relapse of peptic ulcer. Tropical Gastroenterology 1990;11:173-185.

115. Lam SK . Why do ulcers heal with sucralfate? Scand J Gastroenterol 1990;25 (Suppl 173):6-16.

116. Cho C.H., Chen B.W., Hui W.M., Lam S.K. The influence of acute or chronic nicotine treatment on ethanol-induced gastric mucosal dam-age in rats. Dig Dis & Sci 1990;35:106-112.

117. Ng M.T.T., Lam S.K. Gastrointestinal bleeding: a review of treatment options. Med Progress 1990.

118. Branicki F.J., Coleman S.Y., Tuen H.H., Cheung W.L., Pritchett C.J., Jok P.J., Fan S.T., Lai E.C.S., Mok F.P.T., Lam S.K., Hui W.M., Ng M.M.T., Lam D.K.H., Tang A.P.K., Tse M.C.K., Wong J. Acute non-variceal up-per gastrointestinal bleeding in Hong Kong: a prospective evaluation in 1049 patients. European J Gastroenterol Hepatol 1990;2:309-325.

119. Cho C.H., Chen B.W., Hui W.M., Luk C.T., Lam S.K. Endogenous prostaglandins: its role in gastric mucosal blood flow and ethanol ul-ceration in rats. Prostaglandins 1990;40:397-403.

120. Hui W.M., Chen B.W., Cho C.H., Luk C.T., Lam S.K. The effect of miso-prostol, omeprazole and sucralfate on nicotine-ethanol induced gas-tric injury and gastric mucosal blood flow - a comparative study. J Gastroenterol Hepatol 1990;5:653-8.

121. Cho C.H., Liao N.X., Liu X.G., Hui W.M., Luk C.T., Lam S.K. Effect of adenosine on gastric and cardiovascular systems, and ethanol ulcera-tion in male and female rats. European J Pharmacol 1991;201:157-162.

122. Farrell G.C., Lam S.K., Mathan V.I., Okuda K. The J Gastroenterol Hep-atol: The first five years... and the next. J Gastroenterol Hepatol 1991;6:1-2.

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123. Hui W.M., Shiu L.P., Lam S.K. The perception of life events and daily stress in nonulcer dyspepsia. Am J Gastroenterology 1991;86:292-6.

124. Hui W.M., Chen B.W., Cho C.H., Luk C.T., Lam S.K. The effect of com-ponents of sucralfate on gastric mucosal blood flow. European J Gas-troenterol Hepatol 1991;3:169-173.

125. Hui W.M., Ng M.M.T., Lok A.S.F., Lai C.L., Lau Y.N., Lam S.K. A ran-domized comparative study of laser photocoagulation, heater probe and bipolar electrocoagulation in the treatment of active bleeding ul-cers. Gastrointest Endos 1991;37:299-304.

126. Hui W.M., Ho J., Chen B.W., Cho C.H., Lam S.K. Nicotine induced gas-tric injury - protective effects of sucralfate and feeding - a quantita-tive macroscopic and microscopic analysis. Gut 1991;32:372-6.

127. Lam S.K. Treatment of duodenal ulcer with sucralfate. Scand J Gas-troenterol 1991;26(suppl 185):22-28.

128. Hui W.M., Ho J., Lam S.K. The pathogenetic role of Helicobacter pylori in duodenal ulcer disease - a multivariate analysis of the factors af-fecting relapse. Dig Dis & Sci 1991;36:424-30.

129. Hui W.M., Lam S.K., Ho J., Lai C.L., Lok A.S.F., Ng M.M.T., Lau W.Y., Branicki F.J. The effect of omeprazole on duodenal ulcer associated antral gastritis & Helicobacter pylori. Dig Dis Sci, 1991;36:577-582.

130. Hui W.M., Chen B.W., Cho C.H., Luk C.T., Lam S.K. The role of gastric mucosal blood flow in cytoprotection. Digestion 1991;48:113-128.

131. Toouli J., Lam S.K., Stevenson G., Choi T.K., Berci G., Mack E., Moody F.. Symptomatic gallstones. HB Surg 1991;4:255-260.

132. Branicki F.J., Coleman S.Y., Pritchett C.J., Fan S.T., Lai E.C.S., Lau P.W.K., Mok F.P.T., Cheung W.L., Tuen H.H., Fok P.J., Lam D.K.H., Tang A.P.K., Tse M.C.K., Lam S.K., Hui W.M., Wong J. Emergency surgical treatment for nonvariceal bleeding of the upper part of the gastroin-testinal tract. Surg Gyne Obs 1991;172:113-120.

133. Cho C.H., Chen B.W., Hui W.M., Lam S.K., Ogle C.W. The role of the vagus nerve in the protective action of acid inhibitors on ethanol-in-duced gastric mucosal damage in rats. J Gastroenterol Hepatol 1992;7:178-183.

134. Cho C.H., Chen B.W., Hui W.M., Luk C.T., Lam S.K. The cytoprotective effects of zinc L-carnosine on ethanol-induced gastric gland damage in rabbits. J Pharm Pharmacol 1992;44:364-365.

135. Hui W.M., Lam S.K., Lok A.S.F., Ng M.M.T., Lai C.L. Maintenance ther-apy for duodenal ulcer: a randomized controlled comparison of seven forms of treatment. Am J Med 1992;92:265-274.

136. Lam S.K. Antacids revisited. Current Therapeutics 1992;33:61-67.137. Cho C.H., Hui W.M., Liao N.X., Liu X.G., Lam S.K., Ogle C.W.

Polyethyleneglycol: its adverse gastric effects. J Pharm Pharmacol 1992;44:518-520.

138. Branicki F.J., Coleman S.Y., Lam T.C.F., Schroeder D., Tuen H.H., Che-ung W.L., Pritchett J., Lau P.W.K., Lam S.K., Hui W.M., Lam D.K.H., Tse M.C.K., Wong J. Hypotension and endoscopic stigmata of recent haemorrhage in bleeding peptic ulcer: Risk models for rebleeding and mortality. J Gastroenterol Hepatol 1992;7:184-190.

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139. Petersen G.M., Lam S.K., Samloff I.M., Jing L., Rotter J.I. Peptic ulcer disease: ulcer therapy as a gene-environment interaction. Gastroen-terology 1992.

140. Bamberg P., Caswell C.M., Frame M.H., Lam S.K., Wong E.C.K. A meta-analysis comparing the efficacy of omeprazole with H2-receptor antagonists for acute treatment of duodenal ulcer in Asian patients. J Gastroenterol Hepatol 1992;7:577-585.

141. Hui W.M., Shiu L.P., Lok A.S.F., Lam S.K. Life events and daily stress in duodenal ulcer disease. Digestion 1992; 52:165-172.

142. Hui W.M., Lam S.K. Gastric acid secretion, parietal cell sensitivity and endoscopic characteristics of duodenal ulcer patients with and with-out stigmata of recent bleeding. Gastrointest Endos 1992;38:361-364.

143. Hui W.M., Lam S.K. Helicobacter pylori causes cancer: true or false? Am J Gastroenterol 1992;87:1535-1539.

144. Lam S.K. Epidemiology and genetics of peptic ulcer. Gastroenterol Japon 1993;28(suppl 5):145-157.

145. Lam S.K. , Byth K., Ng M.M.T., Hui W.M., McIntosh J., Piper D.W. Perfo-rated peptic ulcer in Hong Kong and New South Wales. J Gastroen-terol Hepatol 1992;7:508-511.

146. Lam S.K. , Hui W.M. Is stress ulcer bleeding still an obnoxious killer in present day ICU's? J Gastroenterol Hepatol 1992;7:553-555.

147. Hui W.M., Chen B.W., Cho C.H., Luk C.T., Lam S.K. The effect of epi-dermal growth factor on gastric mucosal blood flow in rats: possible role in mucosal protection. Gastroenterology 1993;104:1605-1610.

148. Lam S.K. Treatment of peptic ulcer in relation to the effect of nico-tine on gastric mucosal blood flow and acid secretion. J Tokyo Women's Med Coll 1993;63:41-50.

149. Shiu L.P., Hui W.M., Lam S.K. Negative social events, stress, and health in Hong Kong. J Epidemiol Comm Health 1993;47:181-185.

150. Scott A.M., Kellow J.E., Shuter B., Cowan H., Corbett A.M., Riley J.W., Lunzer M.R., Eckstein R.P., Hoschl R., Lam S.K., Jones M.P. Intragas-tric distribution and gastric emptying of solids and liquids in func-tional dyspepsia. Lack of influence of symptom subgroups and Heli-cobacter pylori-associated gastritis. Dig Dis & Sci 1993;38(12):2247-54.

151. Lam S.K. , Lai K.C. Endoscopic haemostasis for gastrointestinal bleed-ing: The dawning of a new era. J Gastroenterol & Hepatol 1994;9:69-74.

152. Ching C.K., Lam S.K. Antacids - indications and limitations. Drugs 1994;47:305-17.

153. Lam S.K. , Cho C.H., Chen B.W., Lai K.C., Ching C.K., Ho C.S., Li Y.N. Gastric cytoprotection by amoxycillin in the rat. J Gastroenterol Hep-atol 1994;9:514-518.

154. Lam S.K. , Ching C.K. Sucralfate in clinical practice. J Gastroenterol Hepatol 1994;9:401-411.

155. Cho C.H., Chen B.W., Ho C.S., Ko J.K.S., Lam S.K. Assessment of hemodynamic changes in rat stomachs by laser doppler velocimetry

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and reflectance spectrophotometry. Effects of ehtanol and prostaglandin E2 under ischemic and congestive conditions. Diges-tion 1994;55:389-394.

156. Ching C.K., Lam S.K. Helicobacter pylori epidemiology in relation to peptic ulcer and gastric cancer in south and north China. J Gastroen-terol & Hepatol 1994;9 (Suppl 1):S4-S7.

157. Lam S.K. Aetiological factors of peptic ulcer: Perspectives of epidemi-ological observations this century. J Gastroenterol & Hepatol 1994;9 (Suppl 1):S93-S98.

158. Lam S.K. Etiology and pathogenesis of peptic ulcer. J Gastroenterol 1994;29 (Suppl VIII):39-54.

159. Lai K.C., Yuen S.T., Ching C.K., Hu H.C., Wong C.Y., Lai C.L., Lam S.K. Tuberculosis of the common bile duct. Illustrated Case Reports in Gastroenterol 1994;1:5-11.

160. Ching C.K., Yuen S.T., Luk I.S.C., Ho J., Lam S.K. The prevalence of Helicobacter pylori carrier rates among the healthy blood donors in Hong Kong. J Hong Kong Med Asso 1994;46:295-298.

161. Ching C.K., Lam S.K. Drug therapy of peptic ulcer disease. Br J Hosp Med 1995;54:101-106.

162. Ko J.K.S., Cho C.H., Lam S.K., Koo M.W.L., Ching C.K. Contributions of physical and chemical properties of mild irritants to gastric cytopro-tection in rats. Pharmacol Lett Life Sciences 1995;57:PL 13-18.

163. Kellow J.E., Cowan H., Shuter B., Riley J.W., Lunzer M.R., Eckstein R.P., Hoschl R., Lam S.K. Efficacy of cisapride therapy in functional dys-pepsia. Alimentary Pharm Thera 1995;9(2):153-60.

164. Ko J.K.S., Cho C.H., Lam S.K., Ching C.K. The importance of gastric emptying and mucosal folds in the adaptive cytoprotection of mild ir-ritants in rats. Inflamm Res. 1995 Dec;44(12):518-22.

165. Lam S.K. Antacids for duodenal ulcer. Current Opinion In Gastroen-terology 1995, in press.

166. Ko J.K.S., Cho C.H., Lam S.K., Koo M.W.L., Ching C.K. Contributions of physical and chemical properties of mild irritants to gastric cytopro-tection in rats. Life Sci 1995;57(1):PL13-8.

167. Lam S.K. , Hui W.M., Shiu L.P., Ng M.M.T. Society stress and peptic ul-cer perforation. J Gastroenterol Hepatol 1995:10:570-576.

168. Lam S.K. , Hu W.H.C., Ching C.K. Sucralfate in Helicobacter pylori eradication strategies. Scand J Gastroenterol 1995;30 (Suppl 210):89-91.

169. Ching C.K., Lam S.K. A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease. J Gastroenterol 1995;30:607-614.

170. Goh K.L., Boonyapisit S., Lai K.H., Chang R., Kang J.Y., Lam S.K. Pre-vention of duodenal ulcer relapse with omeprazole 20 mg daily: A randomized double-blind, placebo-controlled study. J Gastroenterol Hepatol 1995;10:92-97.

171. Ching C.K., Lam S.K. Nonulcer dyspepsia: Association with chronic He-licobacter pylori infection-related gastritis? J Clin Gastroenterol 1995; 21 (Suppl.1):S140-145.

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172. Ching C.K., Leung K.P., Yung R.W.H., Lam S.K., Wong B.C.Y., Lai K.C., Lai C.L. Prevalence of metronidazole resistant Helicobacter pylori strains among Chinese peptic ulcer disease patients and normal con-trols in Hong Kong. Gut 1996;38:675-678.

173. Ching C.K., Wong B.C.Y., Kwok E., Ong L., Covacci A., Lam S.K. Preva-lence of CagA-bearing Helicobacter pylori strains detected by the anti-CagA assay in patients with peptic ulcer disease and in controls. Am J of Gastroenterol 1996;91:949-953.

174. Lau G.K.K., Hui W.M., Lau C.P., Hu W.H.C., Lai K.C., Lam S.K. Oe-sophageal disorders: Abnormal gastro-oesophageal reflux in Chinese with atypical chest pain. J Gastroenterol & Hepatol 1996;11:775-779.

175. Lau G.K.K., Hui W.M., Lam S.K. Life events and daily hassles in pa-tients with atypical chest pain. Amer J Gastroenterol 1996;10:2157-2162.

176. Cheung B.M.Y., Lam S.K. Is there a role for antacids in the modern management of peptic ulcers? Exp Opin Invest Drugs 1996;5:345-353.

177. Hui W.M., Ho J., Chen B.W., Cho C.H., Branicki F.J., Lam S.K. Can misoprostol and omeprazole reduce nicotine and ethanol induced gastric mucosal injury? A quantitative macroscopic and microscopic analysis in rats. J of Gastroenterology & Hepatology 1997;12:7-12.

178. Lau G.K.K., Liang R., Chiu E.K.W., Lee C.K., Lam S.K. Hepatic events after bone marrow transplantation in patients with hepatitis B infec-tion: a case controlled study. Bone Marrow Transplantation 1997;19:795-799.

179. Lau G.K.K., Lok A.S.F., Liang R.H.S., Lai C.L., Chiu E.K.W., Lau Y.L., Lam S.K. Clearance of HBsAg after bone marrow transplantation: role of adoptive immunity transfer. Hepatology 1997;25:1497-1501.

180. Lam S.K. , Ching C.K., Lai K.C., Wong B.C.Y., Lai C.L., Chan C.K., Ong L. Does treatment of Helicobacter pylori with antibiotics alone heal duo-denal ulcer? A randomised double-blind placebo-controlled study. Gut 1997;41:43-48.

181. Lam S.K. Current strategies in ulcer management with special refer-ence to the use of antibiotics. The Yale J of Biology and Medicine 1997;70:27-31.

182. Lai K.C., Hui W.M., Wong B.C.Y., Ching C.K., Lam S.K. A retrospective and prospective study on the safety of discharging selected patients with duodenal ulcer bleeding on the same day as endoscopy. Gas-trointestinal Endoscopy 1997;45:26-30.

183. Ko J.K.S., Ching C.K., Chow J.Y.C., Zhang S.T., Lam S.K., Cho C.H. The vascular and glandular organoprotective properties of metronidazole in the rodent stomach. Aliment Pharmacol Ther 1997;11:811-819.

184. Lau G.K.K., Ng M., Wu W.H.C., Lam S.K. The use of endoscopy in liver diseases. Hong Kong Medical Journal 1997;3:267-273.

185. Ding S.Z., Cho C.H., Lam S.K. Helicobacter pylori induces Interleukin-8 expression in endothelial cells and the signal pathway is protein ty-rosine kinase dependent. Biochemical and Biophysical Research Communications 1997;240:561-565.

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186. Wong B.C.Y., Kwok E., Lam S.K. Diagnosis of Helicobacter pylori in-fection. Journal of Hong Kong Medical Technology Association 1997/98;7:1-7.

187. Lai K.C., Lam S.K. Management of duodenal ulcer bleeding. Chinese Medical Journal 1998;111:3-6.

188. Lam S.K. , Talley N.J. Helicobacter pylori Consensus: Report of the 1997 Asia Pacific Consensus Conference on the management of Heli-cobacter pylori infection. J of Gastroenterology & Hepatology 1998;13:1-12.

189. Hunt R.H., Lam S.K. Helicobacter pylori: From art to a science. J of Gastroenterology & Hepatology 1998;13:21-28.

190. Lau G.K.K., Wu P.C., Lo C.K., Lau V., Lam S.K. Viral Hepatitis: Histo-logical changes of concurrent hepatitis C virus infection in asympto-matic hepatitis B virus patients. J of Gastroenterology & Hepatology 1998;13:52-56.

191. Wong B.C.Y., Ching C.K., Lam S.K., Li Z.L., Chen B.W., Li Y.N., Liu H.J., Liu J.B., Wang B.E., Yuan S.Z., Xu C.P., Hou X.H., Zhang A.T., Zheng Z.T. Differential north to south gastric cancer-duodenal ulcer gradi-ent in China. J of Gastroenterology & Hepatology 1998;13:1050-1057.

192. Tsang K.W.T., Lam S.K., Lam W.K., Karlberg J., Wong B.C.Y., Hu W.H.C., Yew W.W., Ip M.S.M. High sero-prevalence of Helicobacter pylori in active bronchiectasis. The American J of Respiratory & Criti-cal Care Medicine 1998;158:1047-1051.

193. Ding S.Z., Lam S.K., Yuen S.T., Wong B.C.Y., Hui W.M., Ho J., Guo X., Cho C.H. Prostaglandin, tumor necrosis factor a and neutrophils: causative relationship in indomethacin-induced stomach injuries. Eu-ropean Journal of Pharmacology 1998;348:257-263.

194. Lam S.K. , Wong B.C.Y. Helicobacter pylori, peptic ulcer and gastric cancer in China. Yale J Biol Med 1998;71:1-6.

195. Hu W.H.C., Lam S.K. Functional dyspepsia: recent advances in patho-physiology. The Journal of the Hong Kong College of Family Physi-cians 1998;20:327-334.

196. Hu W.H.C., Lam S.K. The current controversies surrounding Heli-cobacter and functional dyspepsia. Medical Progress November 1998:5-8.

197. Zhu G.H., Yang X.L., Lai K.C., Ching C.K., Wong B.C.Y., Yuen S.T., Ho J., Lam S.K. Nonsteroidal antiinflammatory drugs could reverse Heli-cobacter pylori-induced apoptosis and proliferation in gastric epithe-lial cells. Digestive Diseases and Sciences 1998;43:1957-1963.

198. Talley N.J., Lam S.K., Goh K.L., Fock K.M. Dyspepsia Consensus: man-agement guidelines for uninvestigated and functional dyspepsia in the Asia-Pacific region: First Asian Pacific working party on functional dyspepsia. Journal of Gastroenterology and Hepatology 1998;13:335-353.

199. Lau G.K.K., Cheng C.C., Lam S.K. Clinical aspects of Hepatitis C infec-tion. Medical Progress October 1998;25:9-13.

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200. Lau G.K.K., Kwok A., Karlberg J., Lai S.T., Lim W., Leung Y.K., Lam S.K. A twenty-six weeks trial of Thymosin a 1 plus Famciclovir in the treat-ment of Chinese immune tolerant adult patients with chronic hepati-tis B. Acta Pharmacologica Sinica 1998;19:46.

201. Kumana C.R., Ching T.Y., Cheung E., Kong Y., Kou M., Chan C.K., Chu K.M., Seto W.H., Lam S.K. Antiulcer drug prescribing in hospital suc-cessfully influenced by “immediate concurrent feedback”. Clinical Pharmacology & Therapeutics 1998;64:569-574.

202. Wong B.C.Y., Lam S.K., Lai K.C., Hu W.H.C., Ching C.K., Ho J., Yuen S.T., Chan C.K., Lau G.K.K., Lai C.L. Triple therapy for Helicobacter pylori eradication is more effective than long-term maintenance anti-secretory treatment in the prevention of recurrrence of duodenal ul-cer: a prospective long-term follow-up study. Aliment Pharmacology & Therapeutics 1999;13:303-309.

203. Chan A.O.O., Lam C.M., Yuen S.T., Lai C.L., Lam S.K. Cholangio-graphic appearance of hepatic inflammation pseudotumourn and its pathogenic implication. Endoscopy 1999;31(5):S39-40.

204. Zhu G.H., Wong B.C.Y., Eggo M.C., Ching C.K., Yuen S.T., Chan E.Y.T., Lai K.C., Lam S.K. Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activa-tion through inhibition of c-myc. British J of Cancer 1999;79(3/4):393-400.

205. Lau G.K.K., Carman W.F., Locarnini S.A., Okuda K., Lu Z.M., Williams R., Lam S.K. Special Report: treatment of chronic hepatitis B virus in-fection: An Asia-Pacific perspective. Journal of Gastroenterology & Hepatology 1999;14:3-12.

206. Wong B.C.Y., Lam S.K., Ching C.K., Hu W.H.C., Kwok E., Ho J., Yuen S.T., Gao Z., Chen J.S., Lai K.C., Ong L.Y., Chen B.W., Wang W.H., Jiang X.W., Hou X.H., Lu J.Y., the China Gastric Cancer Study Group. Helicobacter pylori infection: Differential Helicobacter pylori infection rates in two contrasting gastric cancer risk regions of South China. Journal of Gastroenterology & Hepatology 1999;14:120-125.

207. Yuen M.F., Lim W.L., Cheng C.C., Lam S.K., Lai C.L. Twelve-year fol-low-up of a prospective randomized trial of Hepatitis B recombinant DNA yeast vaccine versus plasma-derived vaccine without booster doses in children. Hepatology 1999;29:924-927.

208. Zhu G.H., Wong B.C.Y., Ching C.K., Lai K.C., Lam S.K. Differential apoptosis by indomethacin in gastric epilthelial cells through the con-stitutive expression of wide-type p53 and/or Upregulation of c-myc. Biochemical Pharmacology 1999;58:193-200.

209. Wong B.C.Y., Lam S.K. Review: Diet and gastric cancer. GI Cancer 1999;3:1-10.

210. Lai K.C., Lam S.K. The need for Helicobacter pylori eradication ther-apy in patients with peptic ulcer bleeding. Hong Kong Medical Journal 1999;5:163-168.

211. Tsang K.W., Lam S.K. Extragastroduodenal conditions associated with Helicobacter pylori infection. Hong Kong Medical Journal 1999;5:169-174.

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212. Wong B.C.Y., Ching C.K., Lam S.K. Helicobacter pylori infection and gastric cancer. Hong Kong Medical Journal 1999;5:175-179.

213. Wong B.C.Y., Lam S.K., Ching C.K., Hu W.H.C., Ong L.Y., Chen B.W., Gao Z., Chen J.S., Jiang X.W., Hou X.H., Lu J.Y., Wang W.H., Ho J., Yuen S.T., Lai K.C., Kwok E., Hui W.M., Covacci A & the China Gastric Can-cer Study Group. Seroprevalence of cytotoxin-associated gene A pos-itive Helicobacter pylori strains in Changle, an area with very high prevalence of gastric cancer in South China. Alimentary Pharmacol-ogy & Therapeutics 1999;13:1295-1302.

214. Zhu G.H., Wong B.C.Y., Eggo M.C., Yuen S.T., Lai K.C., Lam S.K. Phar-macological inhibition of protein kinase C activity could induce apop-tosis in gastric cancer cells by differential regulation of apoptosis-re-lated gene. Digestive Diseases & Sciences 1999;44:2020-2026.

215. Cheng C., Hui W.M., Lam S.K. Coping style of individuals with func-tional dyspepsia. Psychosomatic Medicine 1999;61:789-795.

216. Chan A.O.O., Luk J.M.C., Hui W.M., Lam S.K. Molecular biology of gas-tric carcinoma: from laboratory to bedside. Journal of Gastroenterol-ogy & Hepatology 1999;14:1150-1160.

217. Tsang K.W., Lam W.K., Kwok E., Chan K.N., Hu W.H.C., Ooi G.C., Zheng L., Wong B.C.Y., Lam S.K. Helicobacter pylori and upper gas-trointestinal symptoms in bronchiectasis. Eur Respir J 1999;14:1345-1350.

218. Tsang K.W., Lam S.K. Review: Helicobacter pylori and extra-digestive diseases. Journal of Gastroenterology & Hepatology 1999;14:844-850.

219. Tally N.J., Axon A., Bytzer P., Holtmann G., Lam S.K., Van-Zanten S. Management of uninvestigated and functional dyspepsia: a working party report for the World Congresses of Gastroenterology. Alimen-tary Pharmacology & Therapeutics 1999; 13(9): 1135-48.

220. Wong B.C.Y., Zhu G.H., Lam S.K. Aspirin induced apoptosis in gastric cancer cells. Biomedicine and Pharmacotherapy 1999;53:315-318.

221. Lam S.K. 9th Seah Cheng Siang Memorial Lecture: Gastric cancer – Where are we now? Annals Academy of Medicine Singapore 1999;28(6):881-889.

222. Yuen M.F., Cheng C.C., Lauder I.J., Lam S.K., Ooi C.G.C., Lai C.L. Early detection of hepatocellular carcinoma increases the chance of treat-ment: Hong Kong experience. Hepatology 2000;31:330-335.

223. Zhu G.H., Wong B.C.Y., Slosberg E.D., Eggo M.C., Ching C.K., Yuen S.T., Lai K.C., Soh J.W., Weinstein I.B., Lam S.K. Overexpression of protein kinase C-ß1 Isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells. Gastroenterology 2000;118:507-514.

224. Wong B.C.Y., Xiao S.D., Hu F.L., Qian S.C., Huang N.X., Li Y.Y., Hu P.J., Daldiyono Mahan C, Lesmana L., Carpio R.E., Perez J.Y., Jr, Fock K.M., Kachintorn U., Phornphutkul K., Kullavanijaya P., Ho J., Lam S.K. Com-parison of Iansoprazole-based triple and dual therapy for treatment of Helicobacter pylori-related duodenal ulcer: an Asian multicentre dou-

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ble-blind randomized placebo controlled study. Alimentary Pharma-cology & Therapeutics 2000;14:217-224.

225. Cheng C., Hui W.M., Lam S.K. Perceptual style and behavioral pattern of individuals with functional gastrointestinal disorders. Health Psy-chology 2000;19:146-154.

226. Tsang K.W., Lam W.K., Chan K.N., Hu W., Wu A., Kwok E., Zheng L., Wong B.C.Y., Lam S.K. Helicobacter pylori sero-prevalence in asthma. Respiratory Medicine 2000; 94:756-760.

227. Lam S.K. Differences in peptic ulcer between East and West. Best Practice & Research in Clinical Gastroenterology 2000;14:41-52.

228. Ma L., Wang W.P., Chow J.Y.C., Lam S.K., Cho C.H. The role of polyamines in gastric mucus synthesis inhibited by cigarette smoke or its extract. Gut 2000;47:170-177.

229. Jeong J.Y., Mukhopadhyay A.K., Dailidiene D., Wang Y., Velapatiño B., Gilman R.H., Parkinson A.J., Nair G.B., Wong B.C.Y., Lam S.K., Mistry R., Segal I., Yuan Y., Gao H., Alarcon T., Brea M.L., Ito Y., Kersulyte D., Lee H.K., Gong Y., Goodwin A., Hoffman P.S., Berg D.E. Sequential in-activation of rdxA (HP0954) and frxA (HP0642) nitroreductase genes causes moderate and high-level metronidazole resistance in Heli-cobacter pylori. Journal of Bacteriology 2000;182:5082-5090.

230. Wang W.H., Wong B.C.Y., Mukhopadhyay A.K., Berg D.E., Cho C.H., Lai K.C., Hu W.H.C., Fung F.M.Y., Hui W.M., Lam S.K. High prevalence of Helicobacter pylori infection with dual resistance to metronidazole and clarithromycin in Hong Kong. Alment Pharmacol Ther 2000;14:901-910.

231. Wong W.M., Wong B.C.Y., Wong K.W., Fung F.M.Y., Lai K.C., Hu W.H.C., Yuen S.T., Leung S.Y., Lau G.K.K., Lai C.L., Chan C.K., Go R., Lam S.K. 13C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese. Aliment Pharmacol Ther 2000;14:1353-1358.

232. Ding S.Z., Cho C.H., Lam S.K. Regulation of interleukin 6 production in a human gastric epithelial cell line MKN-28. Cytokine 2000;12:1129-1135.

233. Wong B.C.Y., Chan C.K., Wong K.W., Wong W.M., Yuen M.F., Lai K.C., Hu W.H.C., Lau G.K.K., Lai C.L., Lam S.K. Management of Dyspepsia: evaluation of a new referral system for the management of dyspepsia in Hong Kong: role of open-access upper endoscopy. Journal of Gas-troenterology & Hepatology 2000;15:1251-1256.

234. Lai K.C., Hui W.M., Wong B.C.Y., Hu W.H.C., Lam S.K. Ulcer-healing drugs are required after eradication of Helicobacter pylori in patients with gastric ulcer but not duodenal ulcer haemorrhage. Aliment Phar-macol Ther 2000;14:1071-1076.

235. Wong B.C.Y., Chang F.Y., Abid S., Abbas Z., Lin B.R., Rensburg C.V., Chen P.C., Schneider H., Simjee A.E., Hamid S.S., Seebaran A., Zhang J., Destefano M., Lam S.K. Triple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africa. Alimentary Pharmacology & Therapeutics 2000;14:1529-1535.

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236. Lai K.C., Hui W.M., Wong W.M., Wong B.C.Y., Hu W.H.C., Ching C.K., Lam S.K. Treatment of Helicobacter pylori in patients with duodenal ulcer hemorrhage – a long-term randomized, controlled study. Amer-ican Journal of Gastroenterology 2000;95:2225-2232.

237. Lau G.K.K., Tsiang M., Hou J., Yuen S.T., Carman W.F., Zhang L., Gibbs C.S., Lam S.K. Combination therapy with lamivudine and famciclovir for Chronic hepatitis B infected Chinese: a viral dynamics study. Hep-atology 2000;32:394-9.

238. Wang W.H., Wong B.C.Y., Lam S.K. Pooled analysis of Helicobacter py-lori eradication regimes in Asia. Journal of Gastroenterology & Hepa-tology 2000;15:1007-16.

239. Wong B.C.Y., Wong W.M., Tang V.S.Y., Lai K.C., Yuen S.T., Hu W.H.C., Chan C.K., Lau G.K.K., Lai C.L., Lam S.K. An Evaluation of Whole Blood Testing for Helicobacter pylori infection in Chinese. Aliment Pharma-col Ther 2000;14:331-335.

240. Kersulyte D., Mukhopadhyay A., Velapatino B., Su W.W., Pan Z.J., Gar-cia C., Hernandez V., Valdez Y., Mistry R.S., Gilman R.H., Yuan Y., Gao H., Alarcon T., Brea M.L., Nair G.B., Chowdhury A., Dutta S., Shirai M., Nakazawa T., Ally R., Segal I., Wong B.C.Y., Lam S.K., Olfat F., Boren T., Engstrand L., Torres O., Schneider R., Thomas J.E., Czinn S., Berg D.E. Differences in Genotypes of Helicobacter pylori from Different Human Populations. J Bacteriol 2000;182:3210-3218.

241. Wong B.C.Y., Chang F.Y., Abid S., Abbas Z., Lin B.R., van Rensburg C., Chen P.C., Schneider H., Simjee A.E., Hamid S.S., Seebaran A., Zhang J., DeStefano M., Lam S.K. Triple therapy with clarithromycin, omepra-zole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africa. Aliment Pharmacol Ther 2000;14:1529-36.

242. Wong B.C.Y., Lam S.K. Treatment regimes for Helicobacter pylori in-fection in Asia Pacific region (in Chinese). J Modern Digestion and In-tervention 2000;5:Suppl 46-48.

243. Hu W.H.C., Lam S.K. Helicobacter pylori and dyspepsia: Still an unre-solved controversy? Journal of Gastroenterology & Hepatology 2000;15:470-472.

244. Wong B.C.Y., Wong W.M., Wang W.H., Fung F.M.Y., Lai K.C., Chu K.M., Yuen S.T., Leung S.Y., Hu W.H.C., Yuen M.F., Lau G.K.K., Chan C.K., Lam S.K. One-week ranitidine bismuth citrate-based triple therapy for the eradication of Helicobacter pylori in Hong Kong with high prevalence of metronidazole resistance. Alimentary Pharmacology & Therapeutics 2001;15:403-409.

245. Jiang X.H., Wong B.C.Y., Yuen S.T., Jiang S.H., Cho C.H., Lai K.C., Lin M.C.M., Kung H.F., Lam S.K. Arsenic trioxide induces apoptosis in hu-man gastric cancer cells through up-regulation of P53 and activation of Caspase-3. International Journal of Cancer 2001;91:173-179.

246. Guo X., Liu E.S.L., Ko J.K.S., Wong B.C.Y., Ye Y.N., Lam S.K., Cho C.H. Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats. European Journal of Pharmacology 2001;411:193-203.

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247. Chan A.O.O., Lam S.K., Chu K.M., Lam C.M., Kwok E., Leung S.Y., Yuen S.T., Hui W.M., Lai K.C., Wong C.Y., Hu H.C., Lai C.L., Law S.Y.K., Wong J. Soluble E-cadherin is a valid prognostic marker in gastric carci-noma. Gut 2001;48(6):808-11.

248. Wong B.C.Y., Wong W.M., Wang W.H., Tang V.S.Y., Young J., Lai K.C., Yuen S.T., Leung S.Y., Hu W.H.C., Chan C.K., Hui W.M., Lam S.K. An evaluation of invasive and non-invasive tests for the diagnosis of Heli-cobacter pylori infection in Chinese-the most accurate tests for rou-tine clinical use and research purpose. Alimentary Pharmacology & Therapeutics 2001;15:505-512.

249. Xia H.H.X., Wong B.C.Y., Talley N.J., Lam S.K. Helicobacter pylori in-fection-current treatment practice. Experts Opinion on Pharmacother-apy 2001;2:253-266.

250. Wong B.C.Y., Wang W.H., Berg D.E., Fung F.M.Y., Lai K.C., Wong W.M., Wong K.W., Lam S.K. High prevalence of mixed infections by Heli-cobacter pylori in Hong Kong: metronidazole sensitivity and overall genotype. Aliment Pharmacol Ther 2001;15:493-504.

251. Wong B.C.Y., Wang W.H., Wong W.M., Lau G.K.K., Fung F.M.Y., Kung N.N.S., Chu K.M., Lai K.C., Hu W.H.C., Hu F.L., Liu X.G., Chan C.K., Yuen M.F., Hui W.M., Lam S.K. Three-day lansoprazole quadruple therapy for Helicobacter pylori-positive duodenal ulcers: a random-ized controlled study. Alimentary Pharmacology & Therapeutics 2001;15:843-849.

252. Chan A.O.O., Chu K.M., Yuen S.T., Leung S.Y., Lam S.K., Wong J. Syn-chronous Gastric Adenocarcinoma and Mucosa-Associated Lymphoid Tissue Lymphoma in Association With Helicobacter pylori Infection: Comparing Reported Cases Between the East and West. American Journal of Gastroenterology 2001;96:1922-1924.

253. Wu A., Lam S.K. An Update on Food Allergy. Medical Progress 2001;April:23-28.

254. Xia H.H.X., Wong B.C.Y., Lam S.K. Helicobacter pylori Infection and Gastric Cancer. Asian Journal of Surgery. 2001;24(3):217-221.

255. Fan X.M., Wong B.C.Y., Wang W.P., Zhou X.M., Cho C.H., Yuen S.T., Leung S.Y., Lin M.C.M., Kung H.F., Lam S.K. Inhibition of proteasome function induced apoptosis in gastric cancer. International Journal of Cancer 2001;93:481-488.

256. Fung P.C.W., Lam S.K. Diseases, Nitric Oxide and Related Potent Therapy. Medical Progress 2001:28(7):19-22.

257. Wang W.P., Guo X., Koo M.W.L., Wong B.C.Y., Lam S.K., Ye Y.N., Cho C.H. Protective role of heme oxygenase-1 on trinitrobenzene sulfonic acid-induced colitis in rats. Am J Physiol Gastrointest Liver Physiol 2001:281:G586-G594.

258. Chan A.O.O., Wong B.C.Y., Lam S.K. Gastric cancer: past, present and future. Canadian Journal of Gastroenterology 2001;15(7):469-474.

259. Huang XR, Hui CWC, Chen YX, Wong BCY, Fung PCW, Metz C, Cho CH, Hui WM, Bucala R, Lam SK, Lan HY. Macrophage migration inhibitory factor is an important mediator in the pathogenesis of gastric inflam-mation in rats. Gastroenterology 2001; 121(3): 619-630.

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260. Wong W.M., Wong B.C.Y., Li T.M., Wong K.W., Cheung K.L., Fung F.M.Y., Xia H.H.X., Lam S.K. Twenty-minute 50 mg 13C-urea breath test without test meal for the diagnosis of Helicobacter pylori infec-tion in Chinese. Alimentary Pharmacology & Therapeutics 2001;15:1499-1504.

261. Wong B.C.Y., Wang W.P., So W.H.L., Shin V.Y., Wong W.M., Fung F.M., Liu E.S.L., Hiu WM, Lam S.K., Cho C.H. Epidermal growth factor and its receptor in chronic active gastritis and gastroduodenal ulcer before and after Helicobacter pylori eradication. Alimentary Pharmacology & Therapeutics 2001;15:1459-1465.

262. Zhou X.M., Wong B.C.Y., Fan X.M., Zhang H.B., Lin M.C.M., Kung H.F., Fan D.M., Lam S.K. Non-steroidal antiinflammatory drugs induced apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis 2001;22(9):1393-1397.

263. Wong B.C.Y., Wang W.P., Cho C.H., Fan X.M., Lin M.C.M., Kung H.F., Lam S.K. 12-Lipoxygenase Inhibition Induced Apoptosis in Human Gastric Cancer cells. Carcinogenesis 2001;22(9):1349-1354.

264. Pfeiffer C.J., Qiu B.S., Lam S.K. Reduction of colonic mucus by re-peated short-term stress enhances experimental colitis in rats. J. Physiol (Paris) 2001;95(1-6):81-7.

265. Fan X.M., Wong B.C.Y., Lin M.C.M., Cho C.H., Wang W.P., Kung H.F., Lam S.K. Interleukin-1b induces cyclo-oxygenase-2 expression in gas-tric cancer cells by the p38 and p44/42 mitogen-activated protein ki-nase signaling pathways. Journal of Gastroenterology & Hepatology 2001;16:1098-1104.

266. Wong W.M., Wong B.C.Y., Tang V.S.Y., Lai K.C., Yuen S.T. Leung S.Y., Hu W.H.C., Lam S.K. Helicobacter pylori Infection: Seroepidemiology, Diagnosis & Treatment: An evaluation of the PyloriTek test for the di-agnosis of Helicobacter pylori infection in Chinese patients before and after eradication therapy. Journal of Gastroenterology & Hepatology 2001;16:976-980.

267. Hui C.K., Lai K.C., Yuen M.F., Ng M., Lai C.L., Lam S.K. Acute cholangi-tis – predictive factors for emergency ERCP. Alimentary Pharmacol-ogy & Therapeutics 2001;15:1633-1637.

268. Jiang X.H., Wong B.C.Y., Lin M.C.M., Zhu G.H., Kung H.F., Jiang S.H., Yang Dan, Lam S.K. Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kB activation in gastric cancer cells. Oncogene 2001;20:8009-8018.

269. Xia H.H.X., Wong B.C.Y., Wong., Wong K.W., Wong S.Y., Wong W.M., Lai K.C., Hu W.H.C., Chan C.K., Lam S.K. Clinical and endoscopic char-acteristics of non-Helicobacter pylori, non-NSAID duodenal ulcers: a long-term prospective study. Alimentary Pharmacology & Therapeu-tics 2001;15:1875-1882.

270. Wong B.C.Y., Wong W.M., Yee Y.K., Hung W.K., Yip A.W.C., Szeto M.L., Li K.F., Lau P., Fung F.M.Y., Tong T.S.M., Lai K.C., Hu W.H.C., Yuen M.F., Hui C.K., Lam S.K. Rabeprazole-based 3-day and 7-day triple therapy vs. omeprazole-based 7-day triple therapy for the treatment

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of Helicobacter pylori infection. Alimentary Pharmacology & Thera-peutics 2001;15:1959-1965.

271. Wong B.C.Y., Yan Y., Berg D.E., Xia H.H.X., Zhang J.Z., Wang W.H., Wong W.M., Huang X.R., Tang V.S.Y., Lam S.K. Distribution of distinct vacA, cagA and iceA alleles in Helicobacter pylori in Hong Kong. Heli-cobacter 2001;6:317-324.

272. Wong W.M., Lai K.C., Lau C.P., Hu W.H.C., Chen W.H., Wong B.C.Y., Hui W.M., Wong Y.H., Xia H.H. X., Lam S.K. Upper gastrointestinal evaluation of Chinese patients with non-cardiac chest pain. Alimen-tary Pharmacology & Therapeutics 2002;16:465-471.

273. Xia H.H.X., Wong B.C.Y., Wong W.M., Tang V.S.Y., Cheung H.K.L., Sham F.N.F., Fung F.M.Y., Lai K.C., Hu W.H.C., Chan C.K., Lam S.K. Optimal serological tests for the detection of Helicobacter pylori in-fection in the Chinese population. Alimentary Pharmacology & Thera-peutics 2002;16:521-526.

274. Wong W.M., Wong B.C.Y., Lu H., Gu Q., Yin Y., Wang W.H., Fung F.M.Y., Lai K.C., Xia H.H.X.,, Xiao S.D., Lam S.K. One-week omepra-zole, furazolidone ad amoxicillin rescue therapy after failure of Heli-cobacter pylori eradication with standard triple therapies. Alimentary Pharmacology & Therapeutics 2002;16:793-798.

275. Wong W.M., Mandir N., Goodlad R.A., Wong B.C.Y., Garcia S.B., Lam S.K., Wright N.A. Histogenesis of human colonic adenomas and hyper-plastic polyps: the role of cell proliferation and crypt fission. Gut 2002;50(2):212-7.

276. Wong W.M., Wong B.C.Y., Xia H.H.X., Tang V.S.Y., Lai K.C., Hu W.H.C., Yuen M.F., Chan C.K., Lam S.K. An evaluation of a rapid urine test for the diagnosis of Helicobacter pylori infection in Chinese. Alimentary Pharmacology & Therapeutics 2002;16:813-7.

277. Xia H.H.X., Wong B.C.Y., Lam S.K. Helicobacter pylori Infection and Gastroduodenal Mucosal Damage and Healing. Gastrointestinal Mu-cosal Repair and Experimental Therapeutics 2002;25:143-157.

278. Wong W.M., Wright N.A., Lam S.K. Origins of Gastrointestinal Cancer. Medical Progress 2002;29(6):17-22.

279. Lai K.C., Lam S.K., Chu K.M., Wong B.C.Y., Hui W.M., Hu W.H.C., Lau G.K.K., Wong W.M., Yuen M.F., Chan A.O.O., Lai C.L., Wong J. Lanso-prazole for the prevention of recurrence of ulcer complications from long-term low-dose aspirin use. New Engl J Med 2002;346(26):2033-2038.

280. Hu W.H.C., Lam K.F., Wong Y.H., Lam C.L.K., Hui W.M., Lai K.C., Wong B.C.Y., Lam S.K. The Hong Kong index of dyspepsia: A validated symptom severity questionnaire for patients with dyspepsia. Journal of Gastroenterology & Hepatology 2002;17(5):545-551.

281. Yang Y., Wong B.C.Y., Lam S.K., Xia H.H.X. Treatment of Helicobacter pylori infection. World Chinese Journal of Digestology 2002;2(5):195-201.

282. Lau G.K.K., Nanji A., Hou J., Fong D.Y.T., Au W.S., Yuen S.T., Lin M., Kung H.F., Lam S.K. Thymosin-a1 and famciclovir combination ther-apy activates T-cell response in patients with chronic hepatitis B virus

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infection in immune-tolerant phase. Journal of Viral Hepatitis 2002;9:280-287.

283. Wong B.C.Y., Jiang X.H., Lam S.K. Role of cyclooxygenase-2 and gas-tric cancer. (in Chinese) J Modern Digestion and Intervention 2002;7(5):69-70.

284. Ng F.H., Wong W.M., Wong B.C.Y., Kng C., Wong S.Y., Lai K.C., Cheng C.S., Yuen W.C., Lam S.K., Lai C.L. Sequential intravenous/oral antibi-otic vs. continuous intravenous antibiotic in the treatment of pyo-genic liver abscess. Alimentary Pharmacology & Therapeutics 2002;16:1083-1090.

285. Xia H.H.X., Wong B.C.Y., Talley N.J., Lam S.K. Alternative and “rescue” treatment regimens for Helicobacter pylori eradication. Experts Opin-ion on Pharmacotherapy 2002; 3(9):1301-1311.

286. Hui C.K., Yuen M.F., Wong W.M., Lam S.K., Lai C.L. Mirtazapine in-duced hepatotoxicity. Journal of Clinical Gastroenterology 2002;35(3):270-271.

287. Jiang X.H., Lam S.K., Lin M.C.M., Jiang S.H., Kung H.F., Slosberg E.D., Son J.W., Weinstein I.B., Wong B.C.Y. Novel Target for Induction of Apoptosis by Cyclooxygenase-2 Inhibitor SC-236 through a Protein Ki-nase C-1-dependent Pathway. Oncogene 2002;21:6113-6122.

288. Chan A.O.O., Lam S.K. Colorectal Cancer Part I – a Review of the Causes. Medical Progress 2002;29(9):11-17.

289. Chan A.O.O., Lam S.K. Colorectal Cancer Part II – Underlying Epige-netic and Genetic Alterations. Medical Progress 2002;29(10):20-24.

290. Chan A.O.O., Lam S.K. Colorectal Cancer Part III – Screening. Medical Progress 2002;29(11):28-31.

291. Wong W.M., Wong B.C.Y., Hung W.K., Yee Y.K., Yip A.W.C., Szeto M.L., Fung F.M.Y., Tong T.S.M., Lai K.C., Hu W.H.C., Yuen M.F., Lam S.K. Double-blind, randomized, placebo-controlled study of four weeks lansoprazole for the treatment of functional dyspepsia in Chinese pa-tients. Gut 2002;51(4):502-506.

292. Wong W.M., Lam S.K., Xia H.H.X., Tang V.S.Y., Lai K.C., Hu W.H.C., Chan C.K., Cheung K.L., Wong B.C.Y. New methods for diagnosis of Helicobacter pylori infection and determination of fecal consistency: Accuracy of a new near patient test for the diagnosis of Helicobacter pylori infection in Chinese. Journal of Gastroenterology & Hepatology 2002;17:1272-1277.

293. Wong B.C.Y., Wong W.M., Chan J.K.F., Lai K.C., Hu W.H.C., Chan C.K., Lam S.K., Carr-Locke D.L. Virtual colonoscopy in China: Virtual colonoscopy for the detection of colorectal polyps and cancers in a Chinese population. Journal of Gastroenterology & Hepatology 2002;17:1323-1327.

294. Hung W.K., Wong W.M., Wong G.S.W., Yip A.W.C., Szeto M.L., Lai K.C., Hu W.H.C., Chan C.K., Xia H.H.X., Yuen M.F., Fung F.M.Y., Tong T.S.M., Ho V.Y.K., Lam S.K., Wong B.C.Y. One-week ranitidine bismuth citrate, amoxicillin and metronidazole triple therapy for the treatment of Heli-cobacter pylori infection in Chinese. Alimentary Pharmacology & Therapeutics 2002;16:2067-2072.

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295. Hui C.K., Lai K.C., Wong W.M., Yuen M.F., Lam S.K., Lai C.L. A ran-domised controlled trial of endoscopic sphincterotomy in acute cholangitis without common bile duct stones. Gut 2002;51(2):245-247.

296. Ng F.H., Lai K.C., Wong B.C.Y., Wong W.M., Wong S.Y., Chow K.C., Yuen S.T., Leung S.Y., Lam S.K. 13C-urea breath test without prior fast-ing and without test meal is accurate for the detection of Helicobac-ter pylori infection in Chinese. J Gastroenterol Hepatol 2002;17(8):834-8.

297. Wong W.M., Lam S.K., Hui W.M., Kai K.C., Chan C.K., Hu W.H.C., Xia H.H.X., Hui C.K., Yuen M.F., Chan A.O.O., Wong B.C.Y. Long-term Prospective Follow-up of Endoscopic Oesophagitis in Southern Chi-nese - Prevalence and Spectrum of the Disease. Alimentary Pharma-cology & Therapeutics 2002;16(12):2037-42.

298. Xia H.H.X., Zhang G.S., Talley N.J., Wong B.C.Y., Yang Y., Henwood C., Wyatt J.M., Adams S., Cheung K., Xia B., Zhu Y.Q., Lam S.K. Topo-graphic association of gastric epithelial expression of Ki-67, Bax and Bcl-2 expression with antralization in the gastric incisura, body and fundus. American Journal of Gastroenterology 2002;97(12):3023-3031.

299. Wong W.M., Wong B.C.Y., Hui C.K., Ng M., Lai K.C., Tso W.K. Lam S.K., Lai C.L. Pyogenic Liver Abscess - retrospective analysis of 80 cases over a 10-year period. Journal of Gastroenterology & Hepatology 2002;17(9):1001-7.

300. Zhang H.B., Wong B.C.Y., Zhou X.M., Guo X.G., Zhao S.J., Wang J.H., Wu K.C., Ding J., Lam S.K., Fan D.M. Effects of somatostatin, oc-treotide and pitressin plus nitroglycerine on systemic and portal haemodynamics in the control of acute variceal bleeding. Interna-tional Jounral of Clinical Practice 2002;56(6):447-51.

301. Hu W.H.C., Lam C.L.K., Lam K.F., Hui W.M., Lai K.C., Xia H.X.H., Lam S.K., Lam B.C.Y. Anxiety but not Depression Determines Health Seek-ing Behaviour in Chinese Patients with Dyspepsia and Irritable Bowel Syndrome: a Population Based Study. Alimentary Pharmacology & Therapeutics 2002;16:2081-2088.

302. Cheng C., Hui W.M., Lam S.K. Coping with first-time endoscopy for a select sample of Chinese patients with functional dyspepsia and duo-denal ulcer: an observational study. Psychosom Med 2002;64(6):867-73.

303. Hui C.K., Lai K.C., Yuen M.F., Ng M.M.T., Lam S.K., Lai C.L. Role of cholecystectomy in preventing recurrent acute cholangitis. Gastroin-testinal Endoscopy 2002;56(1):55-60.

304. Hu W.H.C., Wong N.Y., Lai K.C., Hui W.M., Lam K.F., Wong B.C.Y., Xia H.H.X., Chan C.K., Chan A.O.O., Wong W.M., Tsang K.W., Lam S.K. Normal 24-hour ambulatory proximal and distal gastroesophageal re-flux parameters in Chinese. Hong Kong Med J 2002 Jun;8(3):168-71.

305. Wong W.M., Lai K.C., Shek T.W., Lam S.K. Self-inflicted rectal ulcer with exuberant granulation tissue: a lesion that mimics carcinoma. Gastrointestinal Endoscopy 2002 Jun;55(7):951-2.

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306. Hui C.K., Lai K.C., Yuen M.F., Wong W.M., Lam S.K., Lai C.L. Does with-olding aspirin for one week reduce the risk of post sphincterotomy bleeding. Alimentary Pharmaceutical & Therapeutics 2002;16(5):929-36.

307. Wong W.M., Lai K.C., Ng M., Lam S.K. Mucin-hypersecreting tumor of the common bile duct. J Gastroenterol Hepatol 2002; 17: 924.

308. Wong W.M., Cheng C., Hui W.M., Lam S.K. Noncardiac Chest Pain. Medical Progress 2003;30(1):15-21.

309. Chan A.O.O., Lam S.K., Wong B.C.Y., Kwong Y.L., Rashid A., Tamura G. Gene Methylation in Non-Neoplastic Mucosa of Gastric Cancer: Age or Helicobacter pylori Related? Am J Pathol 2003;163:370-373.

310. Wong W.M., Lam S.K., Lai K.C., Chu K.M., Xia H.H.X., Wong K.W., Che-ung K.L., Lin S.K., Wong B.C.Y. A rapid-release 50-mg tablet-based 13C-urea breath test for the diagnosis of Helicobacter pylori infection. Aliment Pharmacol Ther 2003;17:253-257.

311. Wong B.C.Y., Xia H.H.X., Cheung H.K.L., Ng F.H., Wong S.Y., Chow K.C., Lin S.K., Yin Y., Wong W.M., Yuen M.F., Lam S.K. Helicobacter py-lori and the Gut: Evaluation of two stool antigen tests for the detec-tion of Helicobacter pylori infection in the Chinese population. Journal of Gastroenterology & Hepatology 2003;18:26-31.

312. Yang Y., Deng C.S., Peng J.Z., Wong B.C.Y., Lam S.K., Xia H.H.X. Effect of Helicobacter pylori on apoptosis and apoptosis related genes in gastric cancer cells. Mol Pathol 2003;56:19-24.

313. Xia H.H.X., Lai K.C., Lam S.K., Hu W.H.C., Wong N.Y.H., Hui W.M., Lau C.P., Chen W.H., Chan C.K., Wong W.M., Wong B.C.Y. Symptomatic re-sponse to lansoprazole predicts abnormal acid reflux in endoscopy-negative patients with non-cardiac chest pain. Alimentary Pharmacol-ogy & Therapeutics 2003;17:369-377.

314. Wu J., Xia H.H., Tu S.P., Fan D.M., Lin M.C., Kung H.F., Lam S.K., Wong B.C.Y. 15-lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-in-duced apoptosis in gastric cancer. Carcinogenesis 2003;24(2):243-7.

315. Hui C.K., Lai K.C., Ng M., Wong W.M., Yuen M.F., Lam S.K., Lai C.L., Wong B.C.Y. Retained common bile duct stones: a comparison be-tween biliary stenting and complete clearance of stones by electrohy-draulic lithotripsy. Alimentary Pharmacology & Therapeutics 2003;17:289-296.

316. Xia H.H.X., Wong B.C.Y., Lam S.K. Chemoprevention of gastric cancer: current status. Chinese Medical Journal 2003;116(1):5-10.

317. Wong B.C.Y., Jiang X.H., Fan X.M., Lin M.C.M., Jiang S.H., Lam S.K., Kung H.F. Suppression of RelA/p65 nuclear translocation independent of IKB-a degradation by cyclooxygenase-2 inhibitor in gastric cancer. Oncogene 2003;22:1189-1197.

318. Wang W.H., Wong W.M., Dailidiene D., Berg D.E., Gu Q., Lai K.C., Lam S.K., Wong B.C.Y. Aspirin inhibits the growth of Helicobacter pylori and enhances its susceptibility to antimicrobial agents. Gut 2003;52(4):490-495.

319. Wong W.M., Gu Q., Lam S.K., Fung F.M.Y., Lai K.C., Hu W.H.C., Yee Y.K., Chan C.K., Xia H.H.X., Yuen M.F., Wong B.C.Y. Randomized con-

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trolled study of rabeprazole, levofloxacin and rifabutin triple therapy vs. quadruple therapy as second-line treatment for Helicobacter py-lori infection. Alimentary Pharmaceutical & Therapeutics 2003;17:553-560.

320. Chu K.M., Yuen S.T., Wong W.M., Wong K.W., Lai K.C., Hu W.H.C., Le-ung S.Y., Yuen M.F., Lam S.K., Wong B.C.Y. A Prospective Comparison of Performance of Biopsy Forceps Used in Single Passage with Multi-ple Bites during Upper Endoscopy. Endoscopy 2003;35(4):338-342.

321. Huang J., Lam S.K., Malfertheiner P., Hunt R.H. Has education about Helicobacter pylori infection been effective? Worldwide survey of pri-mary care physicians. J Gastroenterol Hepatol 2003 May;18(5):512-520.

322. Chan A.O.O., Wong B.C.Y., Lan H.Y., Loke S.L., Chan W.K., Hui W.M., Yueng Y.H., Ng I., Hou Laurence., Wong W.M., Yuen M.F., Luk J.M.C., Lam S.K. Deregulation of E-caderin-catenin complex in precancerous lesions of gastric adenocarcinoma. Journal of Gastroenterology & Hepatology 2003;18:534-539.

323. Xia H.H.X., Lam S.K., Wong W.M., Hu W.H.C., Lai K.C., Wong S.H., Le-ung S.Y., Yuen S.T., Wright N.A., Wong B.C.Y. Antralization at the edge of proximal gastric ulcers: Does Helicobacter pylori infection play a role? World J Gastroenterol 2003;9(6):1265-1269.

324. Wong W.M., Lam S.K., Cheung K.L., Tong T.S.M., Rozen P., Young G.P., Chu K.W., Ho J., Law W.L., Tung H.M., Choi H.K., Lee Y.M., Lai K.C., Hu W.H.C., Chan C.K., Yuen M.F., Wong B.C.Y. Evaluation of an Automated Immunochemical Faecal Occult Blood Test for Colorectal Neoplasia Screening in a Chinese Population. Cancer 2003;97:2420-2424.

325. Wong W.M., Lam K.F., Lai K.C., Hui W.M., Hu W.H.C., Lam C.L.K., Wong N.Y.H., Xia H.H.X., Huang J.Q., Chan A.O.O., Lam S.K., Wong B.C.Y. A validated symptoms questionnaire (Chinese-GORDQ) for the diagnosis of gastro-oesophageal reflux disease in Chinese population. Alimentary Pharmacology & Therapeutics 2003;17:1407-1413.

326. Chan A.O.O., Chu K.M., Lam S.K., Wong B.C.Y., Kwok K.F., Law S., Ko S., Hui W.M., Yueng Y.H., Wong J. Soluble E-Cadherin is an Indepen-dent Pretherapeutic Factor for Long-Term Survival in Gastric Cancer. Journal of Clinical Oncology 2003;21(12):2288-2293.

327. Wong W.M., Gu Qing, Wang W.H., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.X.X., Hu W.H.C., Chan C.K., Chan A.O.O., Yuen M.F., Hui C.K., Lam S.K., Wong B.C.Y. Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance. Clinical Infectious Diseases 2003;37(7):882-9.

328. Wong W.M., Lai K.C., Lam K.F., Hui W.M, Hu W.H.C., Lam C.L., Xia H.H., Hung J.Q., Chan C.K., Lam S.K., Wong B.C.Y. Prevalence, clinical spectrum and health care utilization of gastro-oesophageal reflux dis-ease in a Chinese population: a population-based study. Aliment Pharmacol Ther 2003;18(6):595-604.

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329. Cheng C., Chan A.O.O., Hui W.M., Lam S.K. Coping strategies, illness perception, anxiety, and depression of patients with idiopathic consti-pation: A population-based study. Alimentary Pharmacology & Thera-peutics 2003;18(3):319-26.

330. Cheng C., Wong W.M., Lai K.C., Wong B.C.Y., Hu W.H.C., Hui W.M., Lam S.K. Psychosocial factors in patients with noncardiac chest pain. Psychosom Med 2003;65(3):443-9.

331. Lai K.C., Lau C.S., Ip W.Y., Wong B.C.Y., Hui W.M., Hu W.H.C., Wong W.M., Lam S.K. Effect of treatment of Helicobacter pylori on the pre-vention of gastroduodenal ulcers in patients receiving long-term NSAIDs: a double-blined, placebo-controlled trial. Aliment Pharmacol Ther 2003;17(6):799-805.

332. Chan A.O.O., Lam S.K., Wong B.C.Y., Wong W.M., Yuen M.F., Yueng Y.H., Hui W.M., Rashid Asif, Kwong Y.L. Promoter Methylation of E-cadherin Gene in Gastric Mucosa Associated with Helicobacter pylori Infection and in Gastric Cancer. Gut 2003;52(4):502-6.

333. Chan A.O.O., Wong W.M., Lam S.K., Wong B.C.Y. Prevention of gastric cancer. Chinese Journal of Digestive Diseases 2003;4:100-104.

334. Wong W.M., Lam S.K., Tong T.S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu W.H.C., Chan C.K., Yuen M.F., Chan A.O.O., Wong B.C.Y. Evaluation of a rapid stool antigen test for the diagnosis of He-licobacter pylori infection in Chinese patients. Chinese Journal of Di-gestive Diseases 2003;4:132-135.

335. Wong W.M., Ho J.C.M., Hung I.F.N., Ng W., Lam Y.M., Tam W.O., Wong B.C.Y., Wong P.C., Lai C.L., Lam W.K., Lam S.K., Tsang K.W.T., Ooi G.C., Ho P.L., Mok T., Chan J. Temporal patterns of hepatic dysfunc-tion and disease severity in patients with SARS. JAMA 2003;290:2663-2665.

336. Tu S.P., Jiang X.H., Lin M.C.M., Cui J.T., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan A.O.O. Yuen M.F., Lam S.K., Kung H.F., Wong B.C.Y. Suppression of surviving expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer. Cancer Research 2003;63(22):7724-7732.

337. Wong B.C.Y., Wong W.M., Cheung K.L., Tong T.S.M., Rozen P., Young G.P., Chu K.W., Ho J., Law W.L., Tung H.M., Lai K.C., Hu W.H.C., Chan C.K., Lam S.K. A Sensitive Guaiac Fecal Occult Blood Test is Less Use-ful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population. Alimentary Pharmacology and Therapeutics 2003;18(9):941-6.

338. Wang W.H., Huang J.Q., Zheng G.F., Lam S.K., Karlberg J., Wong B.C.Y. Non-steroidal Anti-Inflammatory Drug Use and the Risk of Gas-tric Cancer : A Systematic Review and Meta-analysis. Journal of the National Cancer Institute 2003;95(23):1784-1791.

339. Lai K.C., Lam S.K., Chu K.M., Hui W.M., Kwok K.F., Wong B.C.Y., Hu H.C., Wong W.M., Chan O.O., Chan C.K. Lansoprazole reduces ulcer relapse after eradication of Helicobacter pylori in nonsteroidal anti-in-flammatory drug users--a randomized trial. Aliment Pharmacol Ther 2003;18(8):829-36.

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340. Wong W.M., Lai K.C., Hui W.M., Lam K.F., Huang J.Q., Hu W.H., Wong N.Y., Lam C.L., Xia H.H.X, Chan A.O.O., Lam S.K., Wong B.C.Y. Double-blind, randomized controlled study to assess the effects of lansopra-zole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intra-gastric pH in Chinese subjects with gastro-oesophageal reflux dis-ease. Aliment Pharmacol Ther. 2004 Feb 15;19(4):455-62.

341. Fan X.M., Tu S.P., Lam S.K., Wang W.P., Wu J., Wong W.M., Yuen M.F., Lin M.C.M., Kung H.F., Wong B.C.Y. Five-lipoxygenase-activating pro-tein (FLAP) inhibitor MK-886 Induces Apoptosis in Gastric Cancer Through Upregulation of p27kip1 and Bax. Journal of Gastroenterology & Hepatology 2004;19:31-37.

342. Wong B.C.Y., Lam S.K., Wong W.M., Chen J.S., Zheng T.T., Feng R.E., Lai K.C., Hu W.H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J., Ching C.K., Chen J.S., the China Gastric Cancer Study Group. Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China: A Randomized Controlled Trial. JAMA 2004;291(2):187-194.

343. Wong B.C.Y., Jiang X.H., Lin M.C.M., Tu S.P., Cui J.T., Jiang S.H., Wong W.M., Yuen M.F., Lam S.K., Kung H.F. Cyclooxygenase-2 Inhibitor (SC-236) Suppresses Activator Protein-1 Through c-Jun NH2-Terminal Ki-nase. Gastroenterology 2004;126:136-147.

344. Wong W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu W.H.C., Huang J.Q., Lam C.L.K., Chan C.K., Chan A.O.O., Lam S.K., Wong B.C.Y. Population based study of noncardiac chest pain in southern Chinese: Prevalence, psychosocial factors and health care utilization. World J Gastroenterol 2004;10(5):707-712.

345. Hui C.K., Lai K.C., Yuen M.F., Wong W.M., Chan A.O.O., Ng M., Chan C.K., Cheung W.W., Lam S.K., Lai C.L., Wong B.C.Y. The Role of Chole-cystectomy in Reducing Recurrent Gallstone Pancreatitis. Endoscopy 2004;36(3):206-211.

346. Xia H.H.X., Lam S.K., Huang X.R., Wong W.M., Leung S.Y., Yuen S.T., Lan H.Y., Wong B.C.Y. Helicobacter pylori infection is associated with increased expression of macrophage migration inhibitory factor by epithelial cells, T-cells and macrophages in gastric mucosa. The Jour-nal of Infectious Diseases 2004;190:293-302.

347. Xia H.H.X., Yang Y., Lam S.K., Wong W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A., Wong B.C.Y. Aberrant Epithelial Expression of Trefoil Family Factor 2 and Mucin 6 in Helicobacter pylori-Infected Gastric Antrum, Incisura and Body and Its Association with Antralisation. Jour-nal of Clinical Pathology 2004;57:861-866.

348. Gu Q., Xia H.H.X., Wang W.H., Wang J.D., Wong W.M., Chan A.O.O., Yuen M.F., Lam S.K., Cheung H.W.L., Liu X.G., Wong B.C.Y. Effect of Cyclooxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin. Alimentary Pharmacology & Ther-apeutics 2004;20:675-681.

349. Jiang X.H., Tu S.P., Cui J.T., Lin M.C.M., Xia H.H.X., Wong W.M., Chan A.O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H.F., Soh J.W., Weinstein I.B., Wong B.C.Y. Antisense Targeting Protein kinase C alpha and beta 1 Inhibits Gastric Carcinogenesis. Cancer Research 2004;64:5787-94.

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350. Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu W.H.C., Lam C.L.K., Chan C.K., Lam S.K., Wong B.C.Y. Onset and disap-pearance of reflux symptoms in a Chinese population: a one-year follow-up study. Alimentary Pharmacology Therapeutics 2004;20:803-812.

351. Ko J.K.S., Cho C.H., Lam S.K. Adaptive cytoprotection through modula-tion of nitric oxide in ethanol-evoked gastritis. World J Gastroenterol 2004;10(7):2503-2508.

352. Xia H.H.X., Wong B.C.Y., Zhang G.S., Yang Y., Wyatt J.M., Adams S., Cheung K., Lam S.K., Talley N. Antralization of gastric incisura is topo-graphically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity. Journal of Gastroen-terology & Hepatology 2004;19:1257-1263.

353. Wong W.M., Lai K.C., Hui W.M., Hu W.H.C., Huang J.Q., Wong N.Y.H., Xia H.H.X., Chan A.O.O., Lam S.K., Wong B.C.Y. Pathophysiology of gastroesophageal reflux diseases in Chinese – role of transient lower esophageal sphincter relaxation and esophageal motor dysfunction. Am J Gastroenterol 2004;99:2088-2093.

354. Huang J.Q., Zheng G.F., Chan G.C.F., Karlberg J., Lam S.K., Wong B.C.Y. Efficacy of Current Antiemetic Treatments for Preventing De-layed Chemotherapy-Induced Nausea and Vomiting: A Meta-Analysis of Randomized Controlled Trials. Clinical Research and Regulatory Affairs 2004;21(3&4):191-212.

355. Wong W.M., Xiao S.D., Hu P.J., Wang W.H., Gu Q., Huang J.Q., Xia H.H.X., Wu S.M., Li C.J., Chen M.H., Cui Y., Lai K.C., Hu W.H.C., Chan C.K., Lam S.K., Wong B.C.Y. Standard treatment for Helicobacter py-lori infection is suboptimal in non-ulcer dyspepsia compared to duo-denal ulcer in Chinese. Alimentary Pharmacology and Therapeutics 2005;21:73-81.

356. Xia H.H.X., Zhang S.T., Lam S.K., Lin M.C.M., Kung H.F., Wong B.C.Y. Expression of Macrophage Migration Inhibitory Factor in Esophageal Squamous Cell Carcinoma and Effects of Bile Acids and NSAIDs. Car-cinogenesis 2005;26(1):11-15.

357. Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu W.H.C., Wong W.M., Chan A.O.O., Wong J., Lam S.K. Celecoxib Compared with Lansopra-zole and Naproxen to Prevent Gastrointestinal Ulcer Complications. American Journal of Medicine 2005;118:1271-1278.

358. Tu S.P., Cui J.T., Liston P., Jiang X.H., Xu R., Lin M.C.M., Zhu Y.B., Zou B., Ng S.S.M. Jiang S.H., Xia H.H.X., Wong W.M., Chan A.O.O., Yuen M.F., Lam S.K., Kung H.F., Wong B.C.Y. Gene Therapy for Colon Can-cer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant. Gastroenterology 2005;128:361-375.

359. Gu Q., Wang J.D., Xia H.H.X., Lin M.C., He H., Zou B., Tu S.P., Yang Y., Liu X.G., Lam S.K., Wong W.M., Chan A.O.O., Yuen M.F., Kung H.F., Wong B.C.Y. Activation of Caspase-8/Bid and Bax pathways in aspirin-induced apoptosis in gastric cancer. Carcinogenesis 2005;26(3):541-546.

360. Xia H.H.X., Lam S.K., Chan A.O.O., Lin M.C.M., Kung H.F., Ogura K. Berg D.E., Wong B.C.Y. Macrophage migration inhibitory factor stimu-

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lated by Helicobacter pylori increases proliferation of gastric epithe-lial cells. World Journal of Gastroenterology 2005;11(13):1946-1950.

361. Wang W.H., Huang J.Q., Zheng G.F., Xia H.H.X., Wong W.M., Lam S.K., Wong B.C.Y. Head-to-Head Comparison of H2-Receptor Antagonists and Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Meta-Analysis. World J Gastroenterol 2005;11(26):4067-4077.

362. Lam S.K. Eradication of Helicobacter pylori and Gastric Cancer: Expe-rience in Fujian Province of China. Chinese Journal of Digestive Dis-eases 2005;6:116-118.

363. Wong W.M., Huang J.Q., Xia H.H.X., Fung F.M.Y., Tong T.S.M., Cheung K.L., Ho V.Y.K., Lai K.C., Chan C.K., Chan A.O.O., Hui C.K., Lam S.K. and Wong B.C.Y. Low-Dose Rabeprazole, Amoxicillin and Metronida-zole Triple Therapy for the Treatment of Helicobacter pylori Infection in Chinese Patients. J Gastroenterol Hepatol 2005;20(16)935-940.

364. Wong B.C.Y., Chan A.O.O., Wong K.W., Ching C.K., Wong W.M., Tam S., Lai K.C., Chan C.K., Yuen M.F., Lam S.K. A Pilot Study of Participa-tion in Faecal Occult Blood Testing and Screening Colonoscopy after Health Education in Hong Kong. European Journal of Cancer Preven-tion 2005;14(2):181-184.

365. Wang W.H., Huang J.Q., Zheng G.F., Wong W.M., Lam S.K., Karlberg J., Xia H.H.X., Fass R., Wong B.C.Y. Is Proton Pump Inhibitor Testing an Effective Approach to Diagnose Gastroesophageal Reflux Disease in Patients with Noncardiac Chest Pain?: a Meta-Analysis. Archives of In-ternal Medicine 2005;165(11):1222-1228.

366. Chan A.O.O., Chu K.M., Lam S.K., Cheung K.L., Law S., Kwok K.F., Wong W.M., Yuen M.F., Wong B.C.Y. Early Prediction of Tumor Recur-rence after Curative Resection of Gastric Carcinoma by Measuring Soluble E-cadherin. Cancer 2005;104(4):740-746.

367. Chan A.O.O., Cheng C., Hui W.M., Hu W.H.C., Wong N.Y.H., Lam K.F., Wong W.M., Lai K.C., Lam S.K., Wong B.C.Y. Differing Coping Mecha-nisms, Stress Level and Anorectal Physiology in Patients with Func-tional Constipation. World Journal of Gastroenterology 2005;11(34):5362-5366.

368. Li G.Q., Xia H.H.X., Chen M.H., Gu Q., Wang J.D., Peng J.Z., Chan A.O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H.L., Berg D.E., Feng Z.H., Langenback R., Wong B.C.Y. Effects of Cyclooxyge-nase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflam-mation. J Infect Dis. 2006;193(7):1037-1046.

369. Gu Q., Xia H.H.X., Wang J.D., Wong W.M., Chan A.O.O., Lai K.C., Chan C.K., Yuen M.F., Fung F.M., Wong K.W., Lam S.K., Wong B.C.Y. Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy. Digestion 2006 Jun 20:73(2-3) 101-106.

370. Chan A.O.O., Peng J.Z., Lam S.K., Lai K.C., Yuen M.F., Cheung H.K.L., Kwong Y.L., Rashid A., Chan C.K., Wong B.C.Y. Eradication of Heli-cobacter pylori Infection Reverses E-cadherin Promoter Hypermethy-lation. Gut 2006;55:463-468.

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371. Hu W.H.C., Lam S.K., Lam C.L.K., Wong W.M., Lam K.F., Lai K.C., Wong Y.H., Wong B.C.Y., Chan A.O.O., Chan C.K., Leung G.M., Hui W.M. Comparison between Empirical Prokinetics, Helicobacter test-and-treat and Empirical Endoscopy in Primary-Care Patients Present-ing with Dyspepsia: A One-Year Study. World Journal of Gastroen-terology 2006;12(31): 5010-5016.

372. Chan A.O.O., Huang C., Hui W.M., Choi C.H., Yuen M.F., Lam S.K., Rashid A., Wong B.C.Y. Stability of E-Cadherin Methylation Status in Gastric Mucosa Associated with Histology Changes. Alimentary Phar-macology and Therapeutics 2006;24:831-836.

373. Ouyang Q., Tandon R., Goh K.L., Pan G.Z., Fock K.M., Fiocchi G., Lam S.K., Xiao S.D. Management Consensus of Inflammatory Bowel Dis-ease for the Asia-Pacific Region. Journal of Gastroenterology & Hepa-tology 2006;21(12):1772-1782.

374. Chan AOO, Lam KF, Tong T, Siu DCW, Jim MH, Hui WM, Lai KC, Yuen MF, Lam SK, Wong BCY. Coexistence between Colorectal Cancer/Ade-noma and Coronary Artery Disease: Results from 1382 Patients. Ali-mentary Pharmacology and Therapeutics 2006;24(3):535-539.

375. Li Ping Tang, Chi Hin Cho, Wai Mo Hui, Camy Huang, Kent Man Chu, Harry H.X. Xia, Shiu Kum Lam, Asif Rashid, Benjamin C.Y. Wong, An-nie On On Chan. An Inverse Correlation between Interleukin-6 and Select Gene Promoter Methylation in Patients with Gastric Cancer. Digestion 2006;74:85-90.

376. Lam S.K. History of the Journal of Gastroenterology and Hepatology. Journal of Gastroenterology & Hepatology 2006;21(1):8.

377. Wong BC, Chan AO, Wong WM, Hui WM, Kung HF, and Lam SK. Atti-tudes and knowledge of colorectal cancer and screening in Hong Kong: a population-based study. Journal of gastroenterology and hep-atology 2006;21:41-6.

378. Lai KC, Chu KM, Hui WM, Wong BC, Hung WK, Loo CK,Hu WH, Chan AO, Kwok KF, Fung TT, Wong J, and Lam SK. Esomeprazole with as-pirin versus clopidogrel for prevention of recurrent gastrointestinal ul-cer complications. Clinical gastroenterology and hepatology : the offi-cial clinical practice journal of the American Gastroenterological Asso-ciation. 2006 Jul;4(7):860-5.

379. He H, Xia HH, Wang JD, Gu Q, Lin MC, Zou B, Lam SK, Chan AO, Yuen MF, Kung HF, and Wong BC. Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carci-noma. Cancer. 2006;106(6):1243-9.

380. Cheung T.K., Lam K.F., Hu W.H.C., Lam C.L.K., Wong W.M., Hui W.M., Lai K.C., Lam S.K., Wong B.C.Y. Positve Association between Gastro-Esophageal Reflux Disease and Irritable Bowel Sydnrome in a Chinese Population. Alimentary Pharmacology & Therapeutics 2007;25:1099-1104.

381. Chan A.O.O., Hui W.M., Lam K.F., Leung G., Yuen M.F., Lam S.K., Wong B.C.Y. Familial Aggregation in Constipated Subjects in a Ter-tiary Referral Center. American Journal of Gastroenterology 2007;102(1):149-152.

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382. Chan A.O.O., Lam K.F., Hui W.M., Leung G., Wong N.Y.H., Lam S.K., Wong B.C.Y. Influence of Positive Family History on Clinical Charac-teristics of Functional Constipation. Clinical Gastroenterology and Hepatology 2007;5(2):197-200.

383. Chan A.O.O., Lam K.F., Hui W.M., Leung G., Tong T., Hung I.F.N., Chan P., Hsu A., But D., Wong B.CY., Lam S.K. Patients with Functional Constipation do not Have Increase Prevalence of Colorectal Cancer Precursors. Gut 2007;56(3):451-452.

384. Chan A.O.O., Chu K.M., Huang C., Kwok F.L., Leung S.Y., Sun Y.W., Ko S., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A., Wong B.C.Y. Association between Helicobacter pylori Infection and Interleukin 1beta Polymorphism Predispose to CpG Island Methylation in Gastric Cancer. Gut 2007;56(4):595-7.

385. Chan A.O.O., Hui W.M., Leung G., Hu W.H.C., Lam S.K., Wong B.C.Y. Efficacy of Tegaserod for Functional Constipation in Chinese Subjects: a Randomised Double Blind Controlled Trial in a Single Center. Ali-mentary Pharmacology and Therapeutics 2007;25(4):463-9.

386. Yu L.F., Wang J.D., Zou B., Lin M.C.M., Wu Y.L., Xia H.H.X., Sun Y.W., Gu Q., He H., Lam S.K., Kung H.F., Wong B.C.Y. XAF1 Mediates Apop-tosis Through Extracellular Signal Regulated Kinase Pathway in Colon Cancer. Cancer 2007;109(10):1996-2003.

387. Chan AOO, Hui WM, Leung YC, Hu HC, Lam SK, Wong BCY. Efficacy of Tegaserod for Functional Constipation in Chinese Subjects: a Ran-domized Double-Blind Controlled Trial in a Single Centre. Alimentary Pharamcology and Therapeutics 2007;25(4):463-469.

388. Cheung TK, Lam KF, Hu WHC, Lam CLK, Wong WM, Hui WM, Lai KC, Lam SK, Wong BCY. Positive Association between Gastro-Oe-sophageal Reflux Disease and Irritable Bowel Syndrome in a Chinese Population. Alimentary Pharmacology and Therapeutics 2007;25(9):1099-1104.

389. Chan AOO, Jim MH, Lam KF, Morris JS, Siu DCW, Tong T, Ng FH, Wong SY, Hui WM, Chan CK, Lai KC, Cheung TK, Chan P, Wong G, Yuen MF, Lau YK, Lee S, Szeto ML, Wong BCY, Lam SK. Prevalence of Colorectal Neoplasm among Patients with Newly Diagnosed Coronary Artery Dis-ease. JAMA 2007;298(12):1412-1419.

390. Lam TJ, Wong BC, Mulder CJ, Peña AS, Hui WM, Lam SK, et al. Increas-ing prevalence of advanced colonic polyps in young patients under-going colonoscopy in a referral academic hospital in Hong Kong. World journal of gastroenterology : WJG. 2007 Jul;13(28):3873-7.

391. Zhuang Z, Tsao GSW, Deng W, Wang J, Xia HHX, He H, Feng H, Wang L, Gu Q, Lam SK, Lin MC, Kung HF and Wong BCY. Early Upregulation of Cyclooxygenase-2 in Human Papillomavirus Type 16 and Telom-erase-induced Immortalization of Human Esophageal Epithelial Cells. Journal of Gastroenterology and Hepatology. 2008;23: 1613-1620.

392. Guo-Shuang Feng, Jun-Ling Ma, Benjamin CY Wong, Lian Zhang, Wei-Dong Liu, Kai-Feng Pan, Lin Shen, Xiao-Dong Zhang, Jie Li, Harry HX Xia, Ji-You Li, Shiu Kum Lam, Wei-Cheng You. Celecoxib-related gas-troduodenal ulcer and cardiovascular events in a randomized trial for

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gastric cancer prevention. World J Gastroenterol 2008 July 28; 14(28): 4535-4539.

393. Fock, Kwong Ming; Talley, Nick; Moayyedi, Paul; Hunt, Richard; Azuma, Takeshi; Sugano, Kentaro; Xiao, Shu Dong; Lam, Shiu Kum; Goh, Khean Lee; Chiba, Tsutomu; Uemura, Naomi; Kim, Jae G; Kim, Nayoung; Ang, Tiing Leong; Mahachai, Varocha; Mitchell, Hazel; Rani, Abdul Aziz; Liou, Jyh Ming; Vilaichone, Ratha-korn; Sollano, Jose. Asia-Pacific consensus guidelines on gastric cancer prevention. Jour-nal of Gastroenterology & Hepatology 2008;23(3):351-365.

394. Cheung TK, Wong BC, Lam SK. Gastro-oesophageal reflux disease in Asia : birth of a 'new' disease?. Drugs. 2008;68(4):399-406.

395. Yee, Yuk Kei; Wong, Ka Wah; Hui, Chee Kin; Chan, Chi Kuen; Chan, Annie O O; Lam, Shiu Kam; Fung, Fiona M Y; Hung, Ivan; Wong, Ben-jamin C Y. Prevalence and time trend of intestinal metaplasia in Hong Kong. Journal of Gastroenterology & Hepatology. 24(5):896-899, May 2009.

396. K Ming Fock, Peter Katelaris, Kentaro Sugano, Tiing Leong Ang, Richard Hunt, Nicholas J Talley, Shiu Kum Lam, Shu-Dong Xiao, Huck Joo Tan, Chun-Ying Wu, Hyun Chae Jung, Bui Huu Hoang, Udom Kach-intorn, Khean-Lee Goh, Tsutomu Chiba, Abdul Aziz Rani. Second Asia–Pacific Consensus Guidelines for Helicobacter pylori infection. Journal of Gastroenterology and Hepatology 2009;24: 1587–1600.

397. Li G, Liang J, Li PW, Yao XQ, Pei PZ, Li W, He QH, Yang XF, Chan QCC, Cheung PYS, Ma QY, Lam SK, Cheng PYC, Yang ES. Physiology and cell biology of acupuncture observed in calcium signalling activated by acoustic shear wave. Eur J Physiol 2011 462:587–597.

http://onlinelibrary.wiley.com/doi/10.1111/jgh.2009.24.issue-10/issuetoc

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Chapters

1. Walsh JH, Lam SK. Gastrin physiology and pathology. In: Creutsfeldt W, ed. gastrointestinal hormones. Clinics in Gastroenterology. Lon-don, Philadelphia and Toronto: WB Saunders, 1980;9:567-91.

2. Koo J, Ho JCI, Lam SK, Wong J, Ong GB. Colloidal bismuth in the treat-ment of experimental gastric ulcer: mechanism of action l: Histo-chemical study. In: Umehara S, Ito H, eds. Advances In Experimental Ulcers 1980;586-8.

3. Lam SK . Physiologic abnormalities and heterogeneity of peptic ulcer. In: Rotter JI, Samloff IM and Rimoin DL, eds. International Workshop on Genetics and Heterogeneity of Common Gastrointestinal Disor-ders, New York, London, Toronto, Sydney, San Francisco: Academic Press, 1982;67-80.

4. Lam SK , Koo J. New Approach with Old Medicine: Antacids and Bis-muth. In: Pfeiffer CJ, ed. Drugs and peptic ulcer. Uniscience Series on Gastrointestinal Disease. U.S.A.: CRC Press, Inc., 1982;1:159-82.

5. Walsh JH, Lam SK, Isenberg JI. Autoregulation of gastrin release in duodenal ulcer disease. In: Miyoshi A, ed. Gut peptides and ulcer. Tokyo: Biomedical Research Foundation, 1983;280-3.

6. Koo J, Lam SK, Koo A. Effect of Vagotomy on Acetylcholine-, His-tamine- and Gastrin-Receptors in the Vascular Smooth Muscle of the Rat Gastric Microcirculation. In: Koo A, Lam SK, Smaje, eds. Microcir-culation of the alimentary tract. Singapore: World Scientific Publish-ing Co. Pte. Ltd., Singapore, 1983;327-338.

7. Lam SK . Aetiology of gastric and duodenal ulcer. In Annals of the Academy of Medicine, Singapore, edited by LaBrooy S., 1983;12:498-506.

8. Lam SK . Safety of hepatitis B vaccine and future vaccine. In: V. Vi-ranuvatti, T. Charnuvati, eds. Postgraduate course in Hepatology APASL 1984. Bangkok: Bangkok Mecical Publisher, 1984; 43-49.

9. Lai CL, Wu PC, Lok A, Lam SK, Todd D. Hepatocellular carcinoma and the hepatitis B virus. In: Lam SK, Yeoh EK, Lai CL, eds. Viral hepatitis B infection: Vaccine and control. World Scientific Publishing Co. Pte. Ltd., Singapore, 1984;3-16.

10. Lam SK . Pathogenesis and pathophysiology of duodenal ulcer. In: Isenberg JI, Johanssen C, eds. Peptic ulcer disease. Clinics in Gas-troenterology. London, Philadelphia, Toronto: WB Saunders, 1984;13:447-72.

11. Lam SK . Heterogeneous origin of hyperacidity in duodenal ulcer. In: Kreuning J, Meuwissen SGM, Eriksson AW, eds. Workshop on genetic and clinical aspects of pepsinogen. 1985;255-71.

12. Lam SK . The stomach. In: Gitnick GL, ed. Current Gastroenterology. Chicago, London: Year Book Medical Publishers, 1986;33-62.

13. Lam SK , Hui WM, Ng MTT. The stomach. In: Gitnick GL, ed. Current Gastroenterology. Chicago, London: Year Book Medical Publishers, 1987;31-65.

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14. Lam SK , Chan CW. Diseases of the biliary tract and the gall bladder. In : Gyr K, ed. Tropical Gastroenterology. Clinics in Gastroentero logy. London, Philadelphia, Torronto: WB Saunders 1987;1:297-318.

15. Lam SK . Unique advantages of prostaglandin E analogues in peptic ulcer diseases. In: Prostaglandins in the upper gastrointestinal tract. Therapeutics Today Series. ADIS Press Australia 1986;5:26- 33.

16. Lam SK . Antacids: past, present and future. In: DW Piper, ed. Peptic Ulcer. Clinics in Gastroenterology. London, Philadelphia, Toronto: WB Saunders 1988;2:641-54.

17. Chan CW, Lam SK. Diseases caused by liver flukes and cholangiocar-cinoma. In: Gyr KE, ed. Tropical Gastroenterology. Bailliere's Clinical Gastroenterology, London, Philadelphia, Toronto, Sydney, Tokyo: Bail-liere Tindall, 1987;1:297-318.

18. Lam SK , Hui WM. Research in Gastroenterology. In: Achievemnets in Medicine 1974-1989 In Honour of Professor David Todd. Hong Kong: Hong Kong University Press 1989;45-54.

19. Lam SK . Peptic ulcer: from epidemiology to cause. In: Lam SK, Choi KW, Sung JL, eds. Omeprazole, the First Proton Pump Inhibitor for Peptic Ulcer Disease. J Gastroenterol Hepatol 1989;4 (Suppl 2):1-6.

20. Halter F, Lam SK. Action of antacids: more than bulk neutralization? In: Garner A, Whittle BJ, ed. Advances in drug therapy of gastroin-testinal ulceration. Chichester: John Wiley & Sons 1991;109-120.

21. Lam SK . The role of endoscopy in the diagnosis and treatment of gastrointestinal disease. In: Powell L, Piper D, eds. Textbook of Gas-troenterology, 1991.

22. Halter F, Lam SK. Antacid therapy and ulcer disease. In: Swabb EA, Szabo S, ed. Ulcer Disease: Investigation and Basis for Therapy. Mar-cel Dekker, New York, 1991;167-188.

23. Lam SK . Academic investigator's perspectives of medical treatment for peptic ulcer. In: Swabb EA, Szabo S, ed. Ulcer Disease: Investiga-tion and Basis for Therapy. Marcel Dekker, New York 1991;431-450.

24. Lam SK . Pathogenesis and aetiology of duodenal ulcer. In:Jiang SJ, Xiao SD, Qian BY, ed. Gastroenterology. Shanghai Scientific & Tech-nical Literature Publishers, Shanghai, 1992;126-168.

25. Lam SK . Gastrointestinal bleeding - a new agenda. In: Goonaratna C, de Silva HJ, ed. Gastroenterology Update. Ananda Press, Columbo, Sri Lanka 1993;1-15.

26. Lam SK . Epidemiology and genetics of peptic ulcer. In: Zheng ZT, ed. Textbook of Gastroenterology, Beijing 1994 (Chinese).

27. Lam SK , Hui WM, Ching CK. Epidemiology, pathogenesis and etiology of peptic ulcer. In: Haubrich WS, Schaffner F, Berk JE, eds, Bockus Gastroenterology, WB Saunders, Philadelphia, London, Toronto, Mon-treal, Sydney, Tokyo 1994;1:700-748.

28. Lam SK , Ching CK. Pathophysiology and diagnosis of peptic ulcer. In: Hunt R, ed. Proton pump inhibitors and acid related disorders. Adis International Osaka, 1994;33-48.

29. Lam SK . Therapy of gastric ulcer disease. In: Hollander D, Tytgat GN ed, Sucralfate from basic science to the bedside. Plenum Medical Book Company, New York & London 1995;239-247.

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30. The use of antacids today in the era of Helicobacter pylori, 1997.31. Lam SK . The economics of ageing in Hong Kong. In: Lam SK, ed.

The health of the elderly in Hong Kong. Hong Kong University Press, Hong Kong, 1997;193-199.

32. Lam SK . Epidemiology of peptic ulcer. In: Zheng Zhi Tian, ed. Peptic Ulcer, Beijing 1998 (Chinese).

33. Wong BCY, Lam SK. Gastrointestinal carcinoma: hereditary or infec-tious disease? In: Bioregulation and its disorders in the gastrointesti-nal tract. Eds: T Yoshikawa, T Arakawa. Blackwell Science, Japan. 1998;p305-320.

34. Wong BCY, Zhu GH, Lam SK. Cyclooxygenases, apoptosis and the gastrointestinal tract. In: New concepts and techniques in Gastroen-terology. Eds: SD Xiao. 1999.

35. Chan OO, Lam SK. Molecular biology of gastric cancer. In: Essence of Modern Medicine by Medical School of Ningbo University, May 1999.

Books

1. Koo J, Lam SK, Smaje LH. Microcirculation of the Alimentary Tract. World Scientific Publishing Co. Pte. Ltd., Singapore, 1983.

2. Lam SK , Yeoh EK, Lai CL. Viral hepatitis B infection: Vaccine and con-trol. World Scientific Publishing Co. Pte. Ltd., Singapore, 1984.

3. Lam SK , Misiewicz JJ, Aarimaa M. Site Protection and Cytoprotection in the Management of Peptic Ulcer and Oesophagitis. Scandinavian Journal of Gastroenterology 1987;22 (Suppl 140):1-64.

4. Sabesin SM, Lam SK. International Sucralfate Research Conference. American Journal of Medicine 1987;83 (Supp 3B):1-127.

5. Lam SK , Choi KW, Sung JL. Omeprazole, the First Proton Pump In-hibitor for Peptic Ulcer Disease. J Gastroenterol Hepatol 1989;4 (Suppl 2):1-81.

6. Hunt RH, Porro GB, Bloom BS, Ching CK, Colin-Jones DG, Dent J, Dixon MF, Freston JW, Howden CW, Lam SK, Lazzaroni M, Marks IN, O’Brien BJ, Schubert ML, Shamburek RD, Singh P, Sontag SJ, Tytgat GNJ. Pro-ton Pump Inhibitors and Acid-Related Disroders. Adis International Ltd., Japan 1994

7. Cho CH, Lam SK. Peptic Ulcer: From Experimental Approaches to Clinical Medicine. J Gastroenterol Hepatol 1994;9 (Suppl 1):S1-S109.

8. Lam SK , Paumgartner G, Wang B. Update on Hepatobiliary Diseases 1996. Kluwer Academic Publishers, 1996.

9. Lam SK . Health of the Elderly in Hong Kong. Hong Kong University Press, 1997.

10. Lam SK, Okuda K. Proceedidngs of Australian Gastroenterological Week, Hobart, Tasmania , October 2000, Journal of Gastroenerology & Hepatology.

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Abstracts Presented and Published at International Conferences

1. Lam SK , Sircus W. Evidence for the existence of two populations in duodenal ulcer I. Clinical evidence. Proceedings of 68th Annual Gen-eral Meeting, Association of Physicians of Great Britain and Ireland. Quart JM 1974;43:622-623.

2. Lam SK , Byrnes DJ, Sircus W. Effect of gastroenterotomy on gastrin release. Proceedings 5TH World Congress Of Gastroenterology, Mex-ico City, 1974;p 277.

3. Lam SK , Lai CL. Effect of sulpiride on the cephalic phase of gastric acid and gastrin secretion in duodenal ulcer patients. Proceedings, 5th Asian-Pacific Congress Of Gastroenterology, Singapore 1976;825-830.

4. Lam SK , Lam WK, Cheng FCY, Ong GB. Transabdominal suture of bleeding gastro-oesophageal varices in cryptogenic cirrhosis of the liver Proceedings, 5th Asian-Pacific Congress Of Gastroenterology 1976;545-551.

5. Findlay J, Lam SK, Byrnes DJ, Sircus W, McManus JPA. Relationship between the functional parietal and gastrin cell masses before and after gastric irradiation. Proceedings of 5th Asian-Pacific Congress Of Gastroenterology, Singapore 1976;842-5.

6. Lam SK , Wong KP, Chan PKW, Ngan H, Ong GB. Endoscopic retro-grade cholangiography (ERC) in recurrent pyogenic cholangitis (RPC). Proceedings, British Society Of Gastroenterology, York, Gut 1977;18:A956.

7. Lam SK , Chan RKW, Ong GB. Gastrin release before and after highly selectively vagotomy, truncal vagotomy and pyloroplasty, and truncal vagotomy with antrectomy. Proceedings, 1st Scientific Meeting Of The Association Of Surgeons Of Southeast Asia 1977;p 3.

8. Lam SK , Chan PKW, Wong KP, Tsui JKC, Ngan H, Ong GB. Endoscopic rerograde cholangiopancreatography (ERCP) - a local experience in Hong Kong. Proceedings, 1st Scientific Meeting Of The Association Of Surgeons Of Southeast Asia 1977;p 5.

9. Cheng FCY, Chan PKW, Wong J, Lam SK, Ong GB. Experience in shunting operations for portal hypertention in cirrhosis of liver in Hong Kong. Proceedings1st Scientific Meeting Of The Association Of Surgeons Of Southeast Asia 1977;p 23.

10. Lam SK , Wong KP, Chan PKW, Ngan H, Ong GB. Endosocpic retro-grade cholangiography in recurrent pyogenic cholangitis. 4th World Congress Of Digestive Endoscopy, Madrid 1978;p 41.

11. Lam SK , Lam KC, Lai CL. Treatment of duodenal ulcer with antacid and sulpiride - a double blind controlled trial. 6th World Congress Of Gastroenerology, Madrid 1978;p 44.

12. Lam SK , Sircus W, Chan PKW, Ong GB. Acid and gastrin secretion in Chinese and Scots: normals and with duodenal ulcer. 6th World Con-gress Of Gastroenerology, Madrid 1978;p 86.

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13. Lam SK , Isenberg JI, Lane WH, Hogan D, Chew P, Grossman MI. Gas-tric acid secretion (GAS) is more sensitive to endogenous gastrin in duodenal ulcer (DU) than in normals (N). Gastroenterology 1979;78:1178.

14. Lam SK , Isenberg JI, Hogan D, Lane WH, Grossman MI. Effect of neu-tral and acid meals on gastric acid secretion (GAS), duodenal acid load (DAL), and gastric emptying (GE) in duodenal ulcer (DU) and nor-mals (N). Gastroenterology 1979;78:1178.

15. Koo J, Lam SK, Ong GB. Gastric emptying of solid food in duodenal ul-cer patients before and after proximal gastric and pyloroplasty, and vagotomy and antrectomy. 6th Asian-Pacific Congress Of Gastroen-terology, Auckland 1980;Feb. 10-14, p 2l6.

16. Cheng FCY, Lam SK, Ong GB. A study of gastric acid and pepsin se-cret ion to insulin hypoglycaemia and graded doses of pentagastrin in Chinese patients with duodenal ulcer. 6th Asian-Pacific Congress Of Gastroenterology, Auckland 1980;Feb. l0-l4, p 208.

17. Koo J, Lam SK, Cheng CH and Ong GB. Tripotassium dicitrato bis-muthate (Denol) in the treatment of gastric ulcer. 6th Asian-Pacific Congress Of Gastroenterology, Auckland 1980;Feb 10-14, p 265.

18. Lam SK , Isenberg JI, Lane WH, Walsh JH, Grossman WI. Duodenal ul-cer patients are abnormally sensitive to stimulation of acid secretion by endogenous gastrins released after meals. 6th Asian-Pacific Con-gress Of Gastroenterology, Auckland 1980;Feb. 10-14, p 79.

19. Lam SK . Physiology and pathophysiology of gastrin. 6th Asian-Pacific Congress Of Gastroenterology, Auckland 1980;Feb 10-14, p 18.

20. Lam SK . Normosecreting and hypersecreting duodenal ulcer patients have different pathophysiology. 6th Asian-Pacific Congress Of Gas-troenterology

21. Lam SK , Isenberg JI, Hogan D, Lane WH, Grossman MI. Abnormal re-lationship between duodenal acid load and gastric emptying in duo-denal ulcer. 6th Asian-Pacific Congress Of Gastroenterology, Auck-land 1980;Feb. 10-14, p 78.

22. Lam SK , Hasan M, Sircus W, Wong J, Ong GB, Prescott RJ. A compari-son of the maximal acid output (MAO) in Chinese and Scots, normal and with duodenal ulcer (DU). 6th Asian-Pacific Congress Of Gas-troenterology, Auckland 1980;Feb. 10-14, p 272.

23. Cheng FCY, Shum JDP, Lam SK, Ong GB. A study of -glucuronidase level in patients with primary cholangitis, gall stones and normal con-trols. 6th Asian-Pacific Congress Of Gastroenterology, Auckland 1980;Feb. 10-14, p 180.

24. Lam SK . Heterogeneity of physiologic abnormalities in peptic ulcer. International Workshop Of Genetics And Heterogeneity Of Common Gastro Intestinal Disorders, Indian Wells, California 1980;March 17-19.

25. Koo J, Ho J, Lam SK, Ong GB. Colloid bismuth in the treatment of ex-perimental gastric ulcer. Mechanism of action, I. histochemical study. 4th International Conference For Experimental Ulcer, Tokyo, 1980;Oct. 18-19, p 105.

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26. Wong J, Lam SK, Ong GB, Siu KF. Effects of n-methyl-n-nitroso-guani dine on chronic gastric ulcers in the rat. 4th International Congress For Experimental Ulcer, Tokyo 1980;Oct. 18-19, p 105.

27. Lam SK , Hui KK, Rotter JI, Samloff MI. Pachydermoperiostosis and peptic ulcer. American Gastroenterological Association, Gastroen-terology 1981;80:1202.

28. Lam SK , Koo J, Cheng CH, Ho J, Ong GB. Treatment of corpus and prepyloric gastric ulcers with tripotassium dicitrato bismuthate (De- Nol). Gastroenterology 1981;80:1202.

29. Lam SK , Sircus W. Duodenal ulcers in Edinburgh and Hong Kong. A tale of two cities. Tercentenary Congress, Royal College Of Physi-cians Of Edinburgh 1981;Sept. 6-11.

30. Lam SK , Koo J, Ong GB. Cimetidine versus surgery for recurrent ulcer after gastric surgery. British Society OF Gastroenterology, Gut 1981;A879.

31. Cheng FCY, Shum JDP, Lam SK, Ong GB. The level of B-glucuronidase and D-glucaric acid in bile in patients with primary cholangitis, pig-ment gall stones and normal controls. International Association For The Study Of The Liver, Hong Kong 1982;81.

32. Walsh JH, Lam SK, Isenberg JI. Autoregulation of gastrin release in duodenal ulcer disease. 68th Annual Meeting Of The Japanese Soci-ety Of Gastroenterology, Hiroshima, 1982.

33. Lam SK , Koo J. Effective healing of duodenal ulcer in Chinese patients with half gram daily cimetidine and prediction of healing and non-healing by discriminant analysis. Gastroenterology 1982;82:1108.

34. Lam SK , Koo J. Half gram cimetidine daily is adequate for effective healing of duodenal ulcer in Chinese. VII World Congress Of Gas-troenterology, Stockholm, 1982;15.

35. Koo J, Lam SK, Ngan NK, Ong GB. Rise in incidence of peptic ulcer in Hong Kong. VII World Congress Of Gastroenterology, Stockholm, 1982;147.

36. Koo J, Ho J, Lam SK, Wong J, Ong GB. Selective coating of gastric ul-cer by tripotassium dicitrato bismuthate (De-Nol) VII World Congress Of Gastroenterology, Stockholm, 1982;340.

37. Koo J, Lam SK, Ong GB. Tripotassium dicitrato bismuthate (De-Nol) in the treatment of gastric ulcer. VII World Congress Of Gastroenterol-ogy, Stockholm, 1982;154.

38. Lam SK , Koo J. Accurate pretreatment prediction of duodenal-ulcer healing and non-healing. Gastroenterology, 1983;84:1221.

39. Lam SK , Lok A, Wong E, Wong KL, Hui WM, Fok KH, Ng M. Sulpiride improves functional dyspepsia - a double blind controlled study. Gas-troenterology, 1983;84:1221.

40. Lam SK , Lai CL, Lee NW, Fok KH, Ng M, Siu KF, Wong J. Effective heal-ing of duodenal ulcer with single night time dose of oxmetidine - a double-blind controlled study. Gastroenterology, 1983, 84:1221.

41. Lam SK . Medical management of duodenal ulcer, 1983. 25th Annual Scientific Meeting, Gastroenterological Society Of Australia, Singa pore, 1983;13.

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42. Hui WM, Lai CL, Lam SK. Review of the clinical features of cholangio carcinoma in Hong Kong. Asian Pacific Association For The Study Of Liver, Bangkok 1984;134.

43. Lam SK . A A study of endoscopic sphincterotomy in recurrent pyo-genic cholangitis. Asian Pacific Association For The Study Of Liver, Bangkok 1984;55.

44. Lam SK . Hepatitis B vaccine - safety and future vaccine. Asian Pacific Association For The Study Of Liver. Bangkok 1984;43.

45. Lam SK , Koo J. Gastrin hypersensitivity in cohorts of duodenal ulcer. Gastroenterology 1984;86:1150.

46. Lam SK , Lai CL, Ng M, Fok KH, Hui WM. Meal-time versus bed-time cimetidine in duodenal ulcer-relative efficacy and factors affecting healing. Gastroenterology 1984;86:1150.

47. Wong H, Lam SK. Fasting and meal-stimulated serum somatostatin like immunoreactivity (SLI) in duodenal ulcer patients (DU) and nor-mals. Dig Dis & Sci 1985;29:97S.

48. Lam SK . Pathophysiology of duodenal ulcer. Gastoenterological Soci-ety Of Australia, Update on Peptic Ulceration, Hazelmere, 1984:1.

49. Lam SK . Prognostic factors in peptic ulcer healing. Gastroenterologi-cal Society Of Australia Annual Scientific Meeting, Adelaide, 1984:34.

50. Lam SK , Lau WY, Lai CL, Lee NW, Hui WM, Lok A, Ng M, Fok KH, Yu HC. Efficacy of sucralfate in corpus, prepyloric and duodenal ulcer associated gastric ulcers - a double-blind placebo con trolled study. Sucralfate Symposium, International Congress In Gastroenterology And Digestive Endoscopy, Lisbon, 1984.

51. Lam SK . Medical treatment of peptic ulcer: H2 antagonists, misopros tol, sucralfate. Hong Kong Society Of Gastroenterology Annual Scien-tific Conference 1985:16.

52. Cho CH, Ogle CW, Wong SH, Lam SK. The gastric effects of nicotine and ethanol in rats. 5th International Conference On Experimental Ulcer, Boston, 1985.

53. Lam SK , Lau WY, Choi TK, Lai CL, Lok A, Hui WM, Choi S, Poon GP. Healing of duodenal ulcer (DU) by misoprostol is unaffected by smok ing. Gastroenterology 1985;88.

54. Hui WM, Lam SK, Chan PY, Ho J, Ng MT, Lai CL, Lok A. Pathogenetic role of campylobacter-like organisms in duodenal ulcer. Gut 1985;26:A1117.

55. Hui WM, Liu HC, Lam SK. Human gastric enterochromaffin-like (ECL) cells - demonstration of histamine content and its cholinergic nerve supply. Gut 1985;26:A1145.

56. Hui WM, Ho J, Lam SK, Lui I, Ng MT, Lai CL, Lok A. Natural history of chronic antral gastritis in duodenal ulcer (DU) and its response to treatment with prostaglandin E1 (misoprostol). Gut 1985;26:A1149.

57. Lam SK . Predictive factors of peptic ulcer healing. 32nd Japanese Pepsinogen Research Meeting 1985:22.

58. Lam SK , Rotter JI, Samloff IM. Hyperpepsinogenemia I and hyperacid-ity in early- and late-onset duodenal ulcer. International Workshop On Aspartic Proteinases 1985:14.

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59. Hui WM, Lam SK, Chan PY, Ho J, Ng MT, Lai CL, Lok A. Pathogenetic role of campylobacter-like organisms in duodenal ulcer. Gut 1985;26:A1117.

60. Hui WM, Liu HC, Lam SK. Human gastric enterochromaffin-like (ECL) cells - demonstration of histamine content and its cholinergic nerve supply. Gut 1985;26:A1145.

61. Hui WM, Ho J, Lam SK, Lui I, Ng MTT, Lai CL, Lok A. Natural history of chronic antral gastritis in duodenal ulcer (DU) and its response to treatment with prostaglandin E1 (misoprostol). Gut 1985;26:A1149.

62. Hui WM, Liu HC, Lam SK. Gastric enterochromaffin-like (ECL) cells in dog and man - demonstration of histamine content and cholinergic nerve supply. Gastroenterology 1986;90:1468.

63. Hui WM, Lam SK, Ho J, Chau PY, Lui I, Lai CL, Lok A, Ng MTT. Campy-lobacter-like organisms (CLOS) do not affect the healing of gastric ul-cers (GU). Gastroenterology 1986;90:1468.

64. Hui WM, Liu HC, Lam SK. Gastric enterochromaffin-like (ECL) cells in dog and man - demonstration of histamine content and cholinergic nerve supply. Dig Dis & SciS 1986;31 (Suppl):228S.

65. Hui WM, Lam SK. Multiple duodenal ulcers - natural history and pathophysiology. Dig Dis & SciS 1986;31 (Suppl):307S.

66. Hui WM, Lam SK, Lau WY, Branicki FJ, Lai CL, Lok ASF, Ng MTT, Poon GP, Fok Pj. Omeprazole (OME) vs ranitidine (RAN) for duodenal ulcer (DU) - one-week, low-dose regimens and factors affecting healing. Gastroenterology 1987;92:1443.

67. Hui WM, Lam SK. Is the seasonal variation in the incidence of duode-nal ulcer accompanied by a seasonal variation in gastric acid secre-tion? Gastroenterology 1987;92:1442.

68. Hui WM, Lam SK, Ho J, Lai CL, Lok ASF, Ng MMT, Lui I. Sucralfate (SUC) vs cimetidine (CIM) for the treatment of duodenal ulcer (DU) associated antral gastritis. Gastroenterology 1987;92:1442.

69. Lam SK , Hui WM, Ng MMT. Relationship of perforated peptic ulcer to socio-economic stress over the past 26 years in Hong Kong. Gas-troen terological Society of Australia Annual Scientific Meeting, Alice Springs, 1987:23.

70. Branicki, FJ, Fok PJ, Pritchett CJ, Lam SK, Boey J, Wong J. Bleeding duodenal ulcer - a prospective evaluation of management. Proceed-ings 6th Biennial General Scientific Meeting of the Association of Surgeions of South East Asia, Bangkok, Thailand, 1987;169-170.

71. Hui WM, Lam SK, Ho J, Lui I, Lau WY, Branicki FJ, Lai CL, Lok ASF, Ng MMT. Omeprazole improves antral gastritis associated with duodenal ulcer (DU). Gut 1987;28:A1340.

72. Hui WM, Lam SK, Lau WY, Branicki FJ, Lai CL, Lik ASF, Ng MMT, Poon KP, Fok PJ. Omeprazole (OME) vs ranitidine (RAN) for duodenal ulcer - weekly endoscopic assessment. Gut 1987;28:A1342.

73. Hui WM, Lam SK, Ho J, Lai CL, Lok ASF, Ng MMT, Lui I. Sucralfate (SUC) vs cimetidine (CIM) for the treatment of duodenal ulcer (DU) associated antral gastritis. Gut 1987;28:A1338.

74. Hui WM, Chan M, Lam SK. Smoking affects mucosal gastrin and gas-tric acid secretion in duodenal ulcer (DU). Gut 1987;28:A1374.

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75. Lam SK , Lau WY, Choi TK, Lai CL, Lok A, Hui WM, Choi S, Poon GP. Healing of duodenal ulcer by misoprostol is unaffected by smoking. Postgraduate Medical Journal 1988;64 (Suppl 1):81.

76. Hui WM, Chen BW, Lam SK, Ng MMT, Cho CH, Luk CT. Sucralfate in-creases gastric mucosal blood flow in rats. J Gastroenterol Hepatol 1988;3 (suppl 1):2.

77. FJ, Boey J, Fok PJ, Pritchett CJ, Fan ST, Lai CS, Mok FPT, Woong WS, Lam SK, Hui WM, Ng MMT, Lok ASF, Lam DKH, Tang APK, Wong J. Acute non-varicieal upper gastrointestinal bleeed ing: a prospective evaluation in 502 patients > 60 years. J Gastroenterol Hepatol 1988;3 (suppl 1):3.

78. Hui WM, Ho J, Lam SK. Persistence of campylobacter pylori (CP) dur-ing remission and subsequent relapse in duodenal ulcer (DU). J Gas-troenterol Hepatol 1988;3 (suppl 1):11.

79. Lam SK , Hui WM, Ng MTT, Lok ASF, Lai CL, Branicki F, Lau WY, Poon GP. Reducing meal-stimualted acid secretion achieves faster healing of duodenal ulcer than reducing nocturnal acid secre tion. J Gas-troenterol Hepatol 1988;3 (suppl 1):12.

80. Chen BW, Hui WM, Lam SK, Ng MMT, Cho CH, Luk CT. Effect of miso-prostol and omeprazole on gastric mucosal blood flow in rats - a com-parative study by laser-doppler flowmetry. J Gastroenterol Hepatol 1988;3 (suppl 1):14.

81. Branicki FJ, Boey J, Fok PJ, Pritchett CJ, Fan ST, Lai CS, Mok FPT, Wong WS, Lam SK, Hui WM, Ng MMT, Lok ASF, Lam DKH, Tang APK, Wong J. Bleeding duodenal ulcer (BDU): a prospective evaluation of rebleed-ing and mortality. J Gastroenterolo Hepatol 1988;3 (suppl 1):15.

82. Branicki FJ, Boey J, Fok PJ, Pritchett CJ, Fan St. Lai CS, Mok FPT, Wong WS, Lam SK, Hui WM, Ng MMT, Lok ASF, Lam DKH, Tang APK, Wong J. Acute non-variceal upper gastrointestinal bleeding in Hong Kong: a prospective evaluation in 1049 patients. Proceedings 10th World Congress Collegium Internationale de Chirurgiae Digestivate, Copen-hagen, Denmark, 1988:404.

83. Branicki FJ, Boey J, Fok PJ, Pritchett CJ, Fan ST, Lai CS, Mok FPT, Wong WS, Lam SK. Hui WM, Ng MMT, Lok ASF, Lam DKH, Tang APK, Wong J. Proceedings 10th World Congress Collegium Internationale de Chirur-giae Digestivae, Copenhagen, Denmark, 1988:405.

84. Lam SK , Piper DW, Byth K, Ng MMT, Hui WM, McKintosh J. Peptic ul-cer rates and trends in Hong Kong and Sydney - a tale of two cities. J Gastroenterol Hepatol 1988;3 (suppl 1):16.

85. Lam SK . Peptic ulcer - medical management. Abstracts 8th Asian- Pacific Congress Of Gastroenterology 1988:34.

86. Hui WM, Lam SK. Relationship of sex, age of onset of ulcer symp-toms, smoking, blood group status, and familial dyspeptsia to sea-sonal variability in maximal acid output. Abstracts 8th Asian- Pacific Congress Of Gastroenterology 1988:105.

87. Hui WM, Ho J, Lam SK. Persistence of campylobacter pylori (CP) dur-ing remission and subsequent relapse in duodenal ulcer (DU). Ab-stracts 8th Asian- Pacific Congress Of Gastroenterology 1988:113.

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88. Hui WM, Liu HC, Lam SK. Parietal cells in duodenal ulcer disease: a histochemical study of the effects of omeprazole and ranitidine on mitochrondrial activities. Abstracts 8th Asian- Pacific Congress Of Gastroenterology 1988:122.

89. Hui WM, Chen BW, Lam SK, Ng MMT, Cho Ch, Luk CT. Sucralfate in-creases gastric mucosal blood flow in rats. Abstracts 8th Asian- Pa-cific Congress Of Gastroenterology 1988:245.

90. Chen BW, Hui WM, Lam SK, Ng MMT, Cho CH, Luk CT. Effect of miso-prostol and omeprazole on gastric mucosal blood flow in rats - a com-parative study by laser-doppler flowmetry. Abstracts 8th Asian- Pa-cific Congress Of Gastroenterology 1988:246.

91. Lam SK , Hui WM, Ng MMT, Lai CL, Lok ASF. Comparison of 8 forms of maintenance treatment for duodenal ulcer (DU) and factors affecting relapse. Annual Scientific Meeting Gastroenterological Society Of Australia 1989:33.

92. Hui WM, Chen BW, Cho CH, Lam SK, Luk CT. The effect of compo-nents of sucralfate on gastric mucosal blood flow - does antacid in-crease mucosal blood flow? Gastroenterology 1989;96:A221.

93. Hui WM, J Ho, Chen BW, Cho CH, Lam SK. The effect of sucralfate on vascular injury and its relation to gastric macroscopic and micro-scopic mucosal damage induced by ethanol. Gastroenterology 1989;96:A221.

94. Hui WM, Lam SK, Chau PY, Ho J. Prevalence of campylobacter pylori in non-gastritic mucosa in peptic ulcer disease and non-ulcer dyspep-sia. Gastroenterology 1989;96:A221.

95. Hui WM, Lam SK, Ng MMT, Lai CL, Lok ASF. Long-term maintenance therapy for duodenal ulcer: a comparison of 8 forms of treatments. Gastroenterology 1989;96:A221.

96. Hui WM, Ng MMT, Lok ASF, Lam SK, Yau HH, Lau YN, Lai CL. A ran-domized prospective study of the efficacy of laser, heater probe (HP) and bipolar electrocoagulation (BICAP) in active bleeding ulcers. Gas-troenterology 1989;96:A221.

97. Branicki FJ, Boey J, Fok PJ, Pritchett CJ, Fan ST, Lai CS, Mok FPT, Wong WS, Lam SK, Hui WM, Ng MMT, Laok ASF, Lam DKH, Tang APK, Cole-man SY, Wong J. Risk factors for rebleeding and mortality in 701 pa-tients with bleeding peptic ulcer. Proceedings 7th Congress Asian Surgical Association, Penang, Malaysia, 1989:120.

98. Hui WM, Chen BW, Cho CH, Lam SK, Luk CT. The effect of compo-nents of sucralfate on gastric mucosal blood flow. Annual Scientic Meeting Gastroenterological Society Of Australia 1989:26.

99. Hui WM, Chen BW, Cho CH, Lam SK, Luk CT. Effect of sucralfate com-ponents on gastric mucosal blood flow. Does antacid increase mu-cosal blood flow? J Gastroenterol Hepatol 1989;4 (Suppl 3):21.

100. Hui WM, J Ho, Chen BW, Cho CH, Lam SK. The effect of sucralfate on vascular injury and its relaiton to gastric macroscopic and micro-scopic mucosal damage induced by ethanol. J Gastroenterol Hepatol 1989;4 (Suppl 3):24.

101. Lau WK, Cheung WL, Tuen H, Pritchett CJ, Lam SK, Hui WM, Tse MCK, Lam DKH, Wong J, Branicki FJ. Upper gastrointestinal haemorrhage:

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risk factors for mortality in 177 patients with re bleeding. J Gastroen-terol Hepatol 1989;4 (Suppl 3):25.

102. Branicki FJ, Cheung WL, Tuen H, Lau WK, Pritchett CJ, Schroeder D, Lam SK, Hui WM, Lam DKH, Tse MCk, Tang A, Wong J. Hypotension, endoscopic stigmata, ulcer size and outcome in 1050 patients with bleeding peptic ulcer. J Gastroenterol Hepatol 1989;4(suppl 3):3.

103. Branicki FJ, Cheung WL, Tuen H, Pritchett CJ, Schroder D, Lam DKH, Tse MCK, Lam SK, Hui WM, Tang APK, Wong J. Emergency surgery for non-variceal upper gastrointestinal bleeding (UGIB). J Gastroenterol Hepatol 1989;4 (Suppl 3):36.

104. Hui WM, Lam SK, Shiu LP, Ng MMT. A semi-quantitative study of neg-ative social events, stress and incidence of perforated peptic ulcer in Hong Kong over 24 years. Gastroenterology 1990;98:A61.

105. Hui WM, Liu XG, Cho CH, Chen BW, Luk CT, Lam SK. Calcium channel blocker decreased the gastric mucosal blood flow and worsens ethanol induced gastric mucosal injury. Gastroenterology 1990;98:A62.

106. Hui WM, Shiu LP, Lam SK. The perception of life events and daily has-sles in non-ulcer dyspepsia. Gastroenterology 1990;98:A62.

107. Hui WM, Shiu LP, Lam SK. A dynamic study of psychological factors in active duodenal ulcer (DU) disease and ulcer in remission. Gas-troenterology 1990;98:A62.

108. Hui WM, Ho J, Chen BW, Cho CH, Luk CT and Lam SK. Nicotine in-duced gastric injury - a quantitative macroscopic and microscopic analysis of the protective effects of sucralfate and feeding. Gastroen-terology 1990;98:A62.

109. Lam SK . Acute and long-term treatment of peptic ulcer. Interna-tional Symposium on Losec and Acid Inhibition, Bangkok 1990:16-17.

110. Branicki FJ, Pritchett CJ, Hui WM, Lam SK, Lam TCF, Mok FPT, Tuen HH, Tse MCK, Wong J. Acute nonvariceal upper gastrointestinal bleeding (UGIB) in 86 patients with diabetes mellitus. Proceedings 9th World Congress of Gastroenterology, Sydney, Australia, 1990:85.

111. Hui WM, Chen BW, Cho CH, Luk CT, Lam SK. The effect of epidermal growth factor (EGF) on gastric mucosal blood flow. Gastroenterology 1991;100:A86.

112. Hui WM, Hou XH, Lam SK. The relationship of stigmata of recent haemorrhageto analgesic soncumption. Gastroenterology 1991;100:A87.

113. Hui WM, Lam SK. Gastric acid secretion and parietal cell sensitivity in duodenal ulcer patients with stigmata of bleeding. Gastroenterology 1991;100:A87.

114. Scott A, Kellow J, Cowan H, Shuter B, Riley J, Lunzer M, Eckstein R, Hoschl R, Lam SK, Jones M. Symptom profiles and solid and liquid gastric meptying in non-ulcer dyspepsia with and without H. pylori gastritis. Gastoenterology 1991;100:A492.

115. Lam SK . Safety of acid suppressing drugs: effects of anti-secretory drugs on the liver. Workshop on Appropriate Acid Inhibition for Heal-ing of Acid Related Diseases, June, London, 1991.

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116. Lam SK . Safety of acid suppressing drugs: effects of anti-secretory drugs on endocrine system. Workshop on Appropriate Acid Inhibition for Healing of Acid Related Diseases, June, London, 1991.

117. Lam SK . Peptic ulcer - genetic and environmental factors. J Gas-troenterol & Hepatol 1991;6(suppl 2):10.

118. Lam SK . Peptic ulcer - strengthening the mucosa. J Gastroenterol & Hepatol 1991;6(suppl 2):10.

119. Chen BW, Cho CH, Hui WM, Luk CT, Lam SK. Effects of autacoid (PGs) and chalonic autacoid (indomethacin) on gastric mucosal blood flow and ethanol-induced ulceration in rats. J Gastroenterol & Hepatol 1991;6(suppl 2):11.

120. Lam SK . Antacid therapy today in active duodenal ulcer. Workshop on Antacids, Lisbon, Nov 15-17,1991.

121. Hui WM, Lai KC, Chin K, Lam SK. Can ulcer bleeding patients without stigmata of recent haemorrhage be discharged on the same day - a retrospective and prospective study. Gastroenterology 1992;102:A85.

122. Boonyapisit S, Goh KL, Lai, KH, Chang R, Kang JY, Lam SK. Prevention of duodenal ulcer relapse during maintenance treatment with omeprazole 20 mg o.m. for 12 months compared with placebo - an Asian multicentre trial. 9th Asian-Pacific Congress of Gastroenterol-ogy, 1992:146.

123. Chen BW, Cho CH, Hui WM, Luk CT, Lam SK. Effect of epidermal growth factor on gastric mucosal protection - the mechanism of initial investigation. 9th Asian-Pacific Congress of Gastroen terology, 1992:201.

124. Chen BW, Cho CH, Hui WM, Luk CT, Lam SK. Protective effect of Losec on gastric mucosa. 9th Asian-Pacific Congress of Gastroen-terology, 1992:202.

125. Hu WHC, Lai KC, Hui WM, Hou XH, Lam SK. The relationship of stig-mata of recent haemorrhage to analgesic consumption. 9th Asian-Pacific Congress of Gastroenterology, 1992:162.

126. Lai KC, Hui WM, Chin K, Lam SK. Can ulcer bleeding patients without stigmata of recent haemorrhage be discharged on the same day - a retrospective and prospective study. 9th Asian-Pacific Congress of Gastroenterology, 1992:160.

127. Lam SK . Aetiology and pathogenesis of peptic ulcer. Jap J Gastroen-terol 1993;90:596.

128. Lam SK . Helicobacter pylori gastritis and gastric cancer. J Gastroen-terol & Hepatol 1993;8(suppl 2):S139.

129. Lai KC, Lam SK. Combination therapy with sucralfate and cimetidine significantly heals duodenal ulcers faster than therapy with either drug alone. J Gastroenterol & Hepatol 1993;8(suppl 2):S259.

130. Lai KC, Chen BW, Ho CS, Cho CH, Hui WM, Lam SK. The role of gas-tric microcirculation in protection against ehtanol induced gastric damage. J Gastroenterol & Hepatol 1993;8(suppl 2):S259.

131. Hu WHC, Lam SK, Ho J, Luk SC, Yuen SC, Chan CK, Chung HT, Lai CL, Lai KC, Ng M, Ong L. Gastric metaplasia, Helicobacter pylori and the

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healing and relapse of duodenal ulcers. J Gastroenterol & Hepatol 1993;8(suppl 2):S263.

132. Ching CK, Lam SK. Helicobacter pylori epidemiology in relation to peptic ulcer and gastric cancer in south and north China. J Gastroen-terol & Hepatol 1994;9:A1.

133. Lai KC, Lam SK, Cho CH, Chen BW, Ho CS, Ching CK, Li YN. Gastric cytoprotection by amoxicillin in the rat. J Gastroenterol & Hepatol 1994;9:A9.

134. Yuen ST, Luk ISC, Ho J, Lai KC, Ching CK, Hu WHC, Lam SK. Combina-tion therapy using sucralfate and cimetidine shows significant reduc-tion in active inflammation and gastric metaplasia in healed duodenal ulcers. J Gastroenterol & Hepatol 1994;9:A10.

135. Hu WHC, Lam SK, Ching CK, Chan CK, Chung HT, Lai CL, Lai KC, Ng MMT. Omeprazole or sucralfate combined with clarithromycin and metronidazole in Helicobacter pylori eradication and ulcer healing. J Gastroenterol & Hepatol 1994;9:A11.

136. Lam SK . Aetiology and therapy of peptic ulcer: projection from the present into the future. J Gastroenterol & Hepatol 1994;9:A17.

137. Lam SK . Chronic gastritis - clinical significance. Taisho International Symposium on Gastroenterology, April 6-7 1994, Hakone Japan, Ab-stracts; SV-3:27.

138. Lai KC, Ching CK, Wong CY, Ng M, Chung HT, Hu W, Chan CK, Lam SK. A study of the efficacy of sucralfate in the prevention of rebleeding after endoscopic therapy of bleeding peptic ulcer. Gastroenterology 1994;106:A116.

139. Lai KC, Hui WM, Wong CY, Ching CK, Ng M, Chung HT, Hu W, Lam SK. A randomized controlled study of the efficacy of polidocaol in the pre-vention of rebleeding from peptic ulcer with non-bleeding visible ves-sel. Gastroenterology 1994;106:A116.

140. Lai KC, Lam SK, Cho CH, Chen BW, Ho CS, Ching CK, Li YN. Gastric cytoprotection by amoxicillin in the rat. Gastroenterology 1994;106:A117.

141. Lai KC, Lam SK, Cho CH, Ching CK. Gastric cytoprotection by clar-ithromycin in the rat. Gastroenterology 1994;106:A117.

142. Hu WHC, Lam SK, Ching CK, Chan CK, Chung HT, Lai CL, Lai KC, Lau CF, Ng MMT. Omeprazole or sucralfate combined with clarithromycin and metronidazole in Helicobacter pylori eradication and ulcer heal-ing. 10th World Congresses of Gastroenterology 1994;abstracts II:82P.

143. Wong BCY, Ching CK, Lam SK, Hu WHC, Lai KC, Tam FSF. Sero-epi-demiology of Helicobacter pylori infection in Hong Kong. 10th World Congresses of Gastroenterology 1994;abstracts II:746P.

144. Ching CK, Lai KC, Hu WHC, Lam SK. Cannulatome aided selective cannulation of the abnormal left intrahepatic bile duct. 10th World Congresses of Gastroenterology 1994;abstracts II:1876P.

145. Hu WHC, Lau GKK, Lai KC, Hui WM, Lam SK. Role of abnormal gastro-oesophageal reflux (GOR) among Chinese with atypical chest pain. 10th World Congresses of Gastroenterology 1994;abstracts II:1904P.

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146. Lau GKK, Hui WM, Hu WHC, Lau CP, Wen QS, Lu JY, Lam SK. Life events and daily hassles in atypical chest pain patients - a case con-trolled study. 10th World Congresses of Gastroenterology 1994;ab-stracts II:1905P.

147. Lai KC, Lam SK, Cho CH, Chen BW, Ho CS, Ching CK, Li YN. Gastric cytoprotection by amoxicillin in the rat. 10th World Congresses of Gastroenterology 1994;abstracts II:1975P.

148. Chen BW, Ching CK, Cho CH, Ho J, Hui WM, Lam SK. Omeprazole pro-tection of gastsric mucosa against nicotine and ethanol injury in the rat. 10th World Congresses of Gastroenterology 1994;abstracts II:1978P.

149. Lai KC, Ching CK, Wong CY, Ng M, Chung HT, Hu W, Chan CK, Lam SK. A study of the efficacy of sucralfate in the prevention of rebleeding after endoscopic therapy of bleeding peptic ulcer. 10th World Con-gresses of Gastroenterology 1994;abstracts II:2911P.

150. Hu W, Lam SK, Ching CK, Lai KC, Chan CK, Chung HT, Lai CL, Lau CF, Ng MMT, Ong L. New prospects in Helicobacter pylori eradication. 7th International Sucralfate Symposium, 1994:42.

151. Cho CH, Kaan SK, Ko JKS, Ching CK, Lam SK. The cytoprotective ac-tion of metronidazole in rat stomachs. Gastroenterology 1995;108:A71.

152. Ching CK, Wong BCY, Lam SK, Ong LY. Non-ulcer dyspepsia and cyto-toxin-producing Helicobacter pylori (Hp) strains - Are they related? Gastroenterology 1995;108:A70.

153. Ching CK, Wong BCY, Lam SK, Ong LY, Lai KC, Hu WHC, Lai CL, Lau G, Covacci A. Prevalence of cytotoxin-producing Helicobacter pylori (Hp) strains detected by the anti-CagA Assay (ACAA) among patients with peptic ulcer disease and controls. Gastroenterology 1995;108:A70.

154. Ching CK, Lam SK, Yung RWH, Leung KP, Wong BCY, Lai KC, Ong L, Lai CL, Lau G. Prevalence of metronidazole resistant Helicobacter py-lori (Hp) strains among the Chinese peptic ulcer disease patients and normals in Hong Kong. Gastroenterology 1995;108:A71.

155. Ching CK, Lam SK, Chen BW, Li YN, Wang BE, Zheng ZT, Li ZL, Liu HJ, Liu JB, Yuan SZ, Xu CP, Zhang JK, Zhang AT. North-south gastric can-cer and duodenal ulcer disease gradients in China. Gastroenterology 1995;108:A8.

156. Ong LY, Ching CK, Lam SK, Ko JKS, Cho CH. Gastrointestinal mucosal blood flow (GMBF) by reflectance spectrophotometry (RS) in patients with normal endoscopic findings and duodenal ulcer disease. Gas-troenterology 1995;108:A184.

157. Wong BCY, Ching CK, Lam SK, Lai KC, Hu WHC, Ong LY, Lai CL, Chan CK. Association of Helicobacter pylori (Hp) infection with hypoalbu-minemia and dietary habits. Gastroenterology 1995;108:A260.

158. Ching CK, Lam SK, Wong CY, Hu WHC, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang WH. Mass endoscopic screning for gastric cancer and initiation of Helicobacter pylori (Hp) eradication therapy in Changle of China. Gastroenterology 1995;108:A456.

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159. Wong BCY, Ching CK, Lam SK, Hu WHC, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang QH. The differential Helicobacter pylori (Hp) infection rates in two contrasting gastric cancer risk re-gions of south China. Gastroenterology 1995;108:A553.

160. Chen BW, Liu XG, Xie PY, Lam SK, Cho CH. Microvasculature basis of gastroduodenal mucosal protection by PGE1-misoprostol. J Gastroen-terol Hepatol 1995;10 (Suppl 3):A74.

161. Ching CK, Lam SK, Yung WH, et al. Metronidazole containing regi-mens are less useful for metronidazole resistant (MR) Helicobacter pylori (Hp) strains. J Gastroenterol Hepatol 1995;10 (Suppl 3):A78.

162. Wong BCY, Ching CK, Lam SK, et al. Helicobacter pylori (Hp) does not enhance NSAID-induced gastroduodenal mucosal damage in the el-derly. J Gastroenterol Hepatol 1995;10 (Suppl 3):A82.

163. Chow JYC, Ko, JKS, Yang XL, Su H, Ma L, Lam S.K. Lam, Cho CH. The adaptive organoprotection in rats with gastritis. Gastroenterology 1996;110 (Suppl):A82.

164. Ding SZ, Cho CH, Lam SK, Mei QB, Zhu GH, Yang XL, Su H, Kaan SK, Su HL, Hui WM. Myeloperoxidase activity and prostaglandin E2 deple-tion in indomethacin induced rat gastric mucosal erosions. Gastroen-terology 1996; 110 (Suppl):A96.

165. Hui WM, Chen BW, Cho CH, Luk CT, Lam SK. Nicotine induced gastric injury: a potentiation of direct toxic effect of ethanol, and protection by prostaglandin E2. Gastroenterology 1996; 110 (Suppl):A137.

166. Lai KC, Hui WM, Lam SK. Bleeding ulcers have high false negative rates for antral helicobacter pylori when tested with urease test. Gastroenterology 1996; 110 (Suppl):A167.

167. Lai KC, Yuen ST, Hui WM, Ho J, Lam SK. The role of gastric metaplasia in the relapse of duodenal ulcers. Gastroenterology 1996; 110 (Suppl):A167.

168. Lam SK , Ching CK, Lai KC, Wong BCY, Lai CL, Chan CK, Ong L. Does treatment on Helicobacter pylori (Hp) with antibiotics alone heal duo-denal ulcer (DU)? A randomised double-blind placebo-controlled study. Gastroenterology 1996; 110 (Suppl):A169.

169. Zhu GH, Ching CK, Lam SK, Sheng JZ, Wong TM, Ding SZ. Sialic acid dependent H. pylori lectin as an activator of calcium signal in cul-tured epithelial cells. Gastroenterology 1996; 110 (Suppl):A307.

170. Lau GKK, Hui WM, S Hu, Ngan H, Lam SK. Occurrence of acute gas-troduodenitis after trans-catheter-oily-chemoembolization(TOCE): role of gastroduodenal microcirculation. Gastroenterology 1996; 110 (Suppl):A1246.

171. Lau GKK, Hui WM, Lam S.K. Life events and daily hassles in patients with atypical chest pain. Journal of Gastroenterology and Hepatology 1996; 11 (Suppl.2):A67.

172. Lau GKK, Hui WM, Chan CK, Hu S, Ngan H, Lam S.K. Role of impaired gastroduodenal microcirculation in the occurrence of acute gastro-duodenitis after trans-catheter-oily-chemoembolization (TOCE). Jour-nal of Gastroenterology and Hepatology 1996; 11 (Suppl.2):A70.

173. Kumana CR, Ching TY, Cheung E, Yuen M, Chan CK, Chu KM, Seto WH, Lam SK. Immediate concurrent feedback’ as a means of influ-

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encing hospital use of anti-ulcer drugs. International Conference on Improving Use of Medicines, Chiang Mai, Thailand, 1997.

174. Chan JCK, Lo RHH, Lau NCK, Lam WK, Lam SK. In-hospital resuscita-tion: can we do better? The Hospital Authority Convention 1997.

175. Tsang KWT, Hu W, Lam WK, Ip M, Lam SK. A preliminary study on the gastro-oesophageal reflux in idiopathic bronchiectasis. American Journal of Respiratory and Critical Care Medicine 1997; 155 (Suppl.):A108.

176. Ding SZ, Cho CH, Yuen ST, Zhu GH, Yang XL, Wong BCY, Ho J, Hui WM, Lam SK. Involvement of mucosal TNF-a in the indomethacin-in-duced rat gastric mucosal injury. Gastroenterology 1997; 112 (Suppl):A103.

177. Ding SZ, Yuen ST, Zhu GH, Wong BCY, So HL, Ho J, Hui WM, Cho CH, Lam SK. Neutrophil margination and myeloperoxidase activity in the indomethacin-induced gastric mucosal injury in rats. Gastroenterol-ogy 1997; 112 (Suppl):A103.

178. Hu WHC, Tsang KWT, Lam WK, Lam SK. Abnormal gastroesophageal reflux in patients with bronchectasis. Gastroenterology 1997; 112 (Suppl):A153.

179. Hu WHC, Hui WM, Lam CLK, Lam SK. Anxiety and depression are co-factors determining health care utilisation in patients with dyspepsia: a Hong Kong population based study. Gastroenterology 1997; 112 (Suppl):A153.

180. Lai KC, Wong WM, Hui WM, Wong BCY, Hu WHC, Lam SK. Eradication of helicobacter pylori in patients with duodenal ulcer haemorrhage - 5 years follow up. Gastroenterology 1997; 112 (Suppl):A190.

181. Lai KC, Yuen ST, Ho J, Hui WM, Swain CP, Lam SK. Pathology of vessel in bleeding gastric ulcer: a study in Chinese population and a com-parison with British population. Gastroenterology 1997; 112 (Suppl):A190.

182. Lai KC, Su H, Wong BCY, Hui WM, Kwok E, Covacci A and Lam SK. Prevalence of helicobacter pylori infection and CagA-bearing heli-cobacter pylori strains in Chinese patients on continuous non steroidal anti-inflammatory drugs (NSAIDS). Gastroenterology 1997; 112 (Suppl):A190.

183. Lai KC, Hui WM, Hu WHC, Wong BCY, Kwok E, Lam SK. Serology is not useful in the follow up and confirmation of helicobacter pylori eradication. Gastroenterology 1997; 112 (Suppl):A191.

184. KWT Tsang, Lam SK, Wong BCY, Hu WHC, Karlberg J, Lam WK. High sero-prevalence of helicobacter pylori in bronchiectasis. Gastroen-terology 1997; 112 (Suppl):A315.

185. Wong BCY, Lam SK, Ching CK, Hu WHC, Lai KC, Ong LY, Kwok E, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang QH, Hui WM, Co-vacci A. Effect of Cag-A bearing strains in the eradication of heli-cobacter pylori in a high prevalence area. Gastroenterology 1997; 112 (Suppl):A332.

186. Wong BCY, Lam SK, Lai KC, Hu WHC, Chan CK, Ching CK. Triple ther-apy vs omeprazole maintenance for prevention of duodenal ulcer re-lapse. Gastroenterology 1997; 112 (Suppl):A333.

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187. Wong WM, Lai KC, Hui WM, Wong BCY, Hu WHC, Kwok E, Lai CL, Lam SK. Gastrin hypersensitivity, maximal acid output and gastrin release in relation to helicobacter pylori (Hp) serology and cytotoxin associ-ated antigen (CagA) antibody in duodenal ulcer patients. Gastroen-terology 1997; 112 (Suppl):A333.

188. Yang XL, Cho CH, Mei Q, Lam SK. Ethanol gastritis protects against acetic acid induced gastric ulcer formation in rats and accelerates its healing. Gatroenterology 1997; 112 (Suppl):A338.

189. Zhu GH, Yang XL, Lai KC, Wong BCY, Yuen ST, Ho J, Lam SK. No syn-ergistic effect in the induction of apoptosis in gastric epithelial cells by helicobacter pylori and non-steroidal anti-inflammatory drugs. Gastroenterology 1997; 112 (Suppl):A342.

190. Hu WHC, Lam SK, Ho J, Ching CK, Lai KC, Ong LY, Wong BCY, Yuen ST, Gao Z, Chau KY, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang QH, Hui WM. Increased prevalence of premalignant histological changes in the population of an area with high gastric cancer inci-dence in China. Gastroenterology 1997;112 (Suppl):A581.

191. Lai KC, Chu KM, Hui WM, Wong BCY, Lam SK. Non-invasive test be-fore endoscopy in area with high prevalence of gastric carcinoma-he-licobacter pylori serology or urea breath test? Gastroenterology 1997;112 (Suppl):A599.

192. Lai KC, Wong BCY, Yuen ST, Ho J, Hu WHC, Ching CK, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang QH, Hui WM, Miki K, Covacci A, Lam SK. Pepsinogen levels in subjects with CagA-bear-ing helicobacter pylori strains from an area with high gastric cancer rate. Gastroenterology 1997;112 (Suppl):A599.

193. Lai KC, Ching CK, Wong BCY, Hu WHC, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang QH, Hui WM, Miki K, Lam SK. Serum pepsinogen levels in different gastroduodenal lesions and in subjects from two areas with contrasting gastric cancer rates. Gas-troenterology 1997;112 (Suppl):A599.

194. Wong BCY, Lam SK, Ching CK, Ho J, Yuen ST, Hu WHC, Lai KC, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang QH. Heli-cobacter pylori (Hp) alone cannot account for development of intesti-nal metaplasia in a high gastric cancer risk region in China. Gas-troenterology 1997;112 (Suppl):A682.

195. Wong BCY, Lam SK, Ching CK, Hu WHC, Lai KC, Kwok E, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang QH, Hui WM, Co-vacci A. Higher prevalence of cytotoxin-producing helicobacter pylori (Hp) strains in an area with higher prevalence of gastric cancer in South China. Gastroenterology 1997; 112 (Suppl):A682.

196. Wong BCY, Zhu GH, Yuen ST, Chan EYT, Yang XL, Ding SZ, Lam SK. Induction of apoptosis by pharmacological inhibitors of protein kinase C in human gastric carcinoma cells. Gastroenterology 1997; 112 (Suppl):A682.

197. Wong BCY, Ho J, Yuen ST, Lam SK, Ching CK, Hu WHC, Lai KC, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang QH, Hui WM. Intestinal metaplasia and gastric metaplasia in helicobacter py-

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lori (Hp) gastritis in a population with high risk for gastric cancer. Gastroenterology 1997; 112 (Suppl):A682.

198. Wong BCY, Zhu GH, Eggo MC, Yuen ST, Chan EYT, Lam SK. Nons-teroidal antinflammatory drugs (NSAID) induces apoptosis in human gastric carcinoma cells. Gastroenterology 1997; 112 (Suppl):A683.

199. Wong BCY, Lam SK, Ho J, Yuen ST, Hu WHC, Ching CK, Kwok E, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang QH, Hui WM, Covacci A. Prevalence of cytotoxin-producing helicobacter pylori (Hp) strains in different stages of the carcinogenesis model in a popu-lation with high risk for gastric cancer. Gastroenterology 1997; 112 (Suppl):A683.

200. Wong BCY, Zhu GH, Eggo MC, Yuen ST, Chan EYT, Lam SK. Protein ki-nase C downregulation rescues indomethacin-induced apoptosis in human gastric carcinoma cells. Gastroenterology 1997;112 (Suppl):A683.

201. Tsang KWT, Lam SK, Lam WK, Ng P, Ip M. High sero-prevalence of Helicobacter pylori in bronchiectasis. The European Respiratory Jour-nal 1997;10 (Suppl.25).

202. Wong BCY, Lam SK. Studies on gastric cancer in Chang-Le, China (Part one) Proceedings of Second National Symposium on Helicobac-ter pylori, Guangzhou, China, 1997:30-5 (in Chinese).

203. Zhu GH, Wong BCY, Ching CK, Yuen ST, Chan YET, Lai KC, Lam SK. Wild-type p53-dependent upregulation of c-myc mRNA is associated with indomethacin induced apoptosis in gastric cancer cells. Journal of Gastroenterology and Hepatology 1997;A182

204. Wong BCY, Zhu GH, Yuen ST, Chan YET, Lai KC, Lam SK. Differential effect of pharmacological inhibitors of protein kinase C in growth inhi-bition and apoptosis of human gastric cancer cells. The 88th annual meeting of AACR, CA, USA, 1997.

205. Cheng C, Hui WM, Lai KC, Lam SK. Coping behaviour as a risk factor of functional dyspepsia. Gastroenterology 1998;114:A90.

206. Ding SZ, Cho CH, Lam SK. H. pylori toxin, TNF-a or LPS induce IL-8 response in endothelial cells and the signal pathway is mediated by protein tyrosine kinase. Gastroenterology 1998;114:A105.

207. Ding SZ, Cho CH, Lam SK. Helicobacter pylori stimulates IL-8 expres-sion from human endothelial cells. Gastroenterology 1998;114:A105.

208. Lai KC, Lam SK, Wong BCY, Hui WM, Hu WHC. A simplified but equally accurate C-13 urea breath test for Helicobacter pylori. Gas-troenterology 1998;A114:A191.

209. Lai KC, Lam SK, Hui WM, Wong BCY, Lau CS, Hu WHC, Wen ZF. Can eradication of Helicobacter pylori prevent future development of pep-tic ulcers in patients receiving long-term continuous nonsteroidal anti-inflammatory drugs. Gastroenterology 1998;114:A192.

210. Lai KC, Lam SK, Hui WM, Wong BCY, Lau CS, Hu WHC, Wen ZF. Eradi-cation of Helicobacter pylori did not accelerate the healing of gastric and duodenal ulcers/erosions in patients on long-term continuous nonsteroidal anti-inflammatory drugs. Gastroenterology 1998;114:A192.

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211. Lai KC, Hui WM, Lam SK, Wong BCY, Chu KM, Wong WM, Hu WHC. Maintenance H2-antagonist is not necessary after eradication of Heli-cobacter pylori in bleeding peptic ulcers. Gastroenterology 1998;114:A192.

212. Wen ZF, Cho CH, Lai KC, Lam SK. Gastric and intestinal toxicity of ni-tro-flurbiprofen in rats. Gastroenterology 1998;114:A329.

213. Wen ZF, Cho CH, Zhu W, Zhang XH, Ma L, Lai KC, Hui WM, PCW Fung, Lam SK. Is inducible nitric oxide synthase (iNOS) involved in the pathogenesis of indomethacin-induced intestinal damage? Gastroen-terology 1998;114:A329.

214. Wong BCY, Lam SK, Ching CK, Ho J, Yuen ST, Kwok E, Hu WHC, Lai KC, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang WH, Miki K, Covacci A. Age is a predicting factor for the association between CagA positive Helicobacter pylori (Hp) infection and serum pepsinogen I:II ratio in a high gastric cancer risk region in China. Gastroenterology 1998;114:A333.

215. Wong BCY, Lam SK, Ching CK, Ho J, Yuen ST, Kwok E, Hu WHC, Lai KC, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang WH, Covacci A. Role of the CagA status in atrophic gastric cancer risk region in China. Gastroenterology 1998;114:A333.

216. Zhu GH, XL Yang, KC Lai, Ching CK, Wong BCY, Hui WM, Yuen ST, Ho J, Lam SK. Nonsteroidal antiinflammatory drugs could reverse Heli-cobacter pylori-induced imbalance between proliferation and apopto-sis in gastric epithelial cells. Gastroenterology 1998;114:A346.

217. Zhu GH, Wong BCY, Ching CK, Yuen ST. Chan YET, Lai KC, Lam SK. Wild-type p53 dependent upregulation of c-myc is associated with differential apoptotic response in indomethacin-treated human gas-tric epithelial cells. Gastroenterology 1998;114:A346.

218. Ding SZ, Cho CH, Lam SK. Induction of interleukin 6 from human gas-tric epithelial cell line MKN-28 and the signal pathway is mediated by protein tyrosine kinase and dexa-methasone-sensitive mechanism. Gastroenterology 1998;114:A585.

219. Ding SZ, Cho CH, Wong bCY, Lai KC, Lau GKK, Hui WM, Lam SK. TNF-a and IL-1b induce interleukin 8 response in human gastric epithelial cells and the signal pathway is mediated by protein tyrosine kinase and dexamethasone-sensitive mechanism. Gastroenterology 1998;114:A585.

220. Wong BCY, Chu KM, Lam SK, Kwok E, Lai KC, Hu WHC, Ching CK. CagA positive strains increase the risk of gastric cancer in Hong Kong with moderate prevalence of Helicobacter pylori infection and gastric cancer mortality. Gastroenterology 1998;114:A705.

221. Wong BCY, Lam SK, Wong WM, Ho J, Yuen ST, Ching CK, Kwok E, Hu WHC, Lai KC, Ong LY, Gao Z, Chen JS, Chen BW, Jiang XW, Hou XH, Lu JY, Wang WH. Helicobacter pylori (Hp) alone cannot account for de-velopment of atrophic gastritis and intestinal metaplasia in a high gastric cancer risk region in China. Gastroenterology 1998;114:A705.

222. Zhu GH, Wong BCY, Ching CK, Lai KC, Lam SK. Downregulation of Protein kinase C inhibits indomethacin-induced apoptosis in gastric

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epithelial cells by differential regulation of apoptosis-related genes. Gastroenterology 1998;114:A709.

223. Wen ZF, Cho CH, Lai KC, Lam SK. The role of nitric oxide in the pathogenesis of duodenal ulcer induced by cysteamine in rats. Gas-troenterology 1998;114:A1113.

224. Wong BCY, Zhu GH, Yuen ST, Chan EYT, Lai KC, Lam SK. Induction of apoptosis by pharmacological inhibitors of protein kinase C in gastric cancer cell line in regulates by p53, c-myc and bcl-2 related protein. AACR annual meeting, 1998, New Orleans, USA.

225. Zhu GH, Wong BCY, Eggo MC, Ching CK, Yuen ST, Chan YET, Lai KC, Lam SK. Indomethacin-induced apoptosis in human gastric cancer cells is mediated by protein kinase C/c-myc pathway. AACR annual meeting, 1998, New Orleans, USA.

226. Tsang KWT, Lam SK, Yew WW, Ip M, Ho CS, Lam WK. Helicobacter pylori sero-prevalence is related to disease activity in bronchictasis. 1998 ALA/ATS International Conference, Chicago, 1998.

227. Chan JCK, Lo RHH, Lau NCK, Lam WK, Lam SK. A retrospective analy-sis of the practice of in-hopital resuscitation in the absence of a do-not-resuscitate (DNR) policy and a resuscitation team. Critical Care Medicine 1998;26(1):A54 (Abst 51).

228. Tsang KWT, Lam SK, Lam WK, Wong BCY, Hu W, Ip M, Karlberg J. He-licobacter pylori IgG correlates with disease activity in Chinese pa-tients with bronchictasis. 1998 APSR, Sydney, Australia.

229. Tsang KWT, Lam WK, Kwok E, Hu H, Wong BCY, Lam SK. Helicobacter pylori CAG a sero-prevalence in Chinese patients with bronchictasis. 1999 ALA/ATS International Conference, San Diego, 1999.

230. Tsang KWT, Hu W, Lam WK, Lam B, Ho JCM, Lam SK. Gastro-oe-sophageal reflux in bronchiectasis. 1999 ALA/ATS International Con-ference, San Diego, 1999.

231. Tsang KWT, Kwok E, Lam WK, Ho JCM, Lam B, Chan KN, Ip M, Lam SK. Helicobacter pylori sero-prevalence in asthma. E.R.S. Annual Con-gress, Madrid, Oct. 1999.

232. Tsang KWT, Lam WK, Kwok E, Leung R, Hu W, Wong BCY, Lam SK. Sero-prevalence of Helicobacter pylori Cag A in Chinese patients with bronchiectasis. E.R.S. Annual Congress, Madrid, Oct. 1999.

233. Tsang KWT, Hu W, Lam WK, Ooi GC, Tipoe G, Lam B, Ho JCM, Lam SK. Gastro-oesophageal reflux (GOR) in bronchiectasis. E.R.S. Annual Congress, Madrid, Oct. 1999.

234. Lau G, Yuen ST, Kwok A, Lai ST, Lim W, Lam SK. Six-months follow-up on 26 weeks trial of thymosin a 1 plus famciclovir in the treatment of Chinese immune tolerant adult patients with chronic Hepatitis B. Gastroenterology 1999;116:A1237.

235. Wong CY, Lam SK, Chan CK, Wong WM, Yuen MF, Hu WHC, Chong MAN, Lai KC. Open access upper endoscopy service in Hong Kong. Gastroenterology 1999;116:A104.

236. Wong CY, Tang VSY, Lam SK, Lai KC, Hu WHC, Lau G, Lai CL, Chan CK, Chan OO. Home-made rapid urease test is as good as commercial kit in testing for Helicobacter pylori in Hong Kong Chinese. Gastroen-terology 1999;116:A356.

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237. Wong CY, Lam SK, Lai KC, Hu WHC, Chan CK, Lau G, Lai CL, Ong L, Ching CK. Triple therapy for Helicobacter pylori(Hp) eradication is more effective than long-term maintenance anti-secretary treatment in the prevention of recurrence of gastric ulcer: a prospective long-term follow-up study. Gastroenterology 1999;116:A356.

238. Wong CY, Wong KW, Lam SK, Lai KC, Hu WHC, Lau GKK, Lai CL, Chan CK, Chan OO, Go R. A simplified C13-urea breath test for detection of Helicobacter pylori (Hp) infection. Gastroenterology 1999;116:A356.

239. Wong CY, Tang VSY, Lam SK, Lai KC, Hu WHC, Lau G, Lai CL, Chan OO, Chan CK. Evaluation of whole blood testing for Helicobacter py-lori in Chinese. Gastroenterology 1999;116:A357.

240. Lam SK , Wong CY. Prospective double-blind randomized placebo-controlled study comparing two Lansoprazole-based triple therapy and one dual therapy for Helicobacter pylori (Hp)-related duodenal ul-cer (DU): an Asian multicenter study. Gastroenterology 1999;116:A357.

241. Chan OO, Chu KM, Hui WM, Wong CY, Kwok E, Lai KC, Lam SK. Serum soluble E-cadherin concentration is a good prognostic marker for pa-tients with gastric cancer. Gastroenterology 1999;116:A386.

242. Chan OO, Lam C, Kwok E, Lam SK, Fan ST. Serum soluble E-cadherin concentration in patients with GI malignancy. Gastroenterology 1999;116:A386.

243. Wong WM, Wong BCY, Goodlad RA, Mandir N, Lam SK, Wright NA. Proliferation characteristics and histogenesis of human colonic polyps – a microdissection study. Gastroenterology 1999;116:A525.

244. Wong CY, Zhang HB, Lam SK, Lai KC, Hu WHC, Fan DM, Leung SY, Yuen ST. Expression of RAS, RAF-1, MEK-1 and MAPK-1 kinase path-way in human pre-malignant gastric lesions and gastric carcinomas. Gastroenterology 1999;116:A530.

245. Wong CY, Ching CK, Lam SK, Wong KW, Tam SCF, Lai KC, Chan CK, Hu WHC. A pilot study of colorectal cancer screening project in Hong Kong. Gastroenterology 1999;116:A530.

246. Zhu GH, Lam SK, Slosberg ED, Eggo MC, Ching CK, Yuen ST, Lai KC, Weinstein IB, Wong CY. Overexpression of protein kinase C b1 isoen-zyme suppresses indomethacin-induced apoptosis in gastric cancer cells. Gastroenterology 1999;116:A531.

247. Wong CY, Jiang XH, Yuen ST, Lam SK, Eggo MC, Lai KC, Hu WHC, Le-ung SY. Arsenic trioxide-induced apoptosis in human gastric cancer is mediated by protein kinase C and P53-dependent pathway. Gas-troenterology 1999;116:A531.

248. Hu WHC, Lam KF, Lam CLK, Wong NYH, Hui WM, Lam SK. A question-naire to assess symptom severity in patients with functional dyspep-sia. Gastroenterology 1999;116:A1010.

249. Chan OO, Chu KM, Lam CM, Kwok E, Lam SK. Serum soluble E-cad-herin is a good prognostic marker in gastric cancer. Gut 1999;45 (Suppl V):A237.

250. Lam SK . Specific inhibitor of 5-lipoxygenase induced apoptosis in gastric cancer cells through activation of caspase-3. 91st Annual Meeting of the American Association for Cancer Research, 2000.

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251. Lam SK . Mechanisms of H. pylori and NSAID in gastric mucosal in-flammation. Gastroenterology Today 2000;4:169.

252. Lam SK . Practical issues in testing and treatment of H. pylori in the Asia Pacific Area. Med J Malaysia, April 2001;56 Supplment A:16.

253. Lam SK . Critical issues in H. pylori treatment. Annual Scientific Meet-ing of the Malaysian Society of Gastroenterology & Hepatology, 2001.

254. Jiang XH, Lam SK, Lin MCM, Cho CH, Lai KC, Kung HF, Yang D, Wong BCY. P53 status determines nuclear factor-kappa B response in Trip-tolide-induced apoptosis in gastric cancer. Proceedings of American Association of Cancer Research Annual Meeting 2001;42:659.

255. Jiang XH, Lam SK. Overexpression of Protein Kinase C-beta1 Isoen-zyme Suppresses SC-236-induced Apoptosis in Gastric Cancer Cells. Gastroenterology 2001;120(5):A664.

256. Zhou XM, Lai KC, Lam SK. Induced gastric mucosal apoptosis in Heli-cobacter pylori positive patients taking low dose aspirin: A 6-month case-control study. Gastroenterology 2001;120(5):A598.

257. Huang JQ, Malfertheiner P, Lam SK, Hunt R. Has education about H. pylori (Hp) infection been effective? – A worldwide survey of primary care physicians (PCPS). Gastroenterology 2001;120(5):A730.

258. Zhang GS, Talley N, Henwood C, Wyatt JM, Adams S, Wong BCY, Lam SK. Topographic association of Ki-67 and Bcl-2 expression with H. py-lori infection, gastric atrophy, intestinal metaplasia: A role for antral-ization in gastric carcinogenesis? Gastroenterology 2001;120(5):A656.

259. Lai KC, Lam SK, Chu KM, Hui WM, Wong BCY, Hu W, Wong WM, Yuen MF, Chan OO, Lai CL, Lau GKK, Chan CK. H. pylori eradication vs combined proton pump inhibitor and H. pylori eradication in the pre-vention of recurrent peptic ulcer complications in High-risk patients receiving low-dose aspirin. Gastroenterology 2001;120(5):A104.

260. Lai KC, Chu KM, Hui WM, Wong BCY, Hu W, Wong WM, Yuen MF, Chan OO, Lai CL, Lau GKK, Chan CK, Lam SK. COX-2 inhibitor compared with proton pump inhibitor in the prevention of recurrent ulcer com-plications in high-risk patients taking NSAIDs. Gastroenterology 2001;120(5):A104.

261. Wong WM, Lam SK, Wang WH, Lau GKK, Kung NN, Chu KM, Lai KC, Hu W, Hu F, Liu X, Yuen MF, Wong BCY. Three-day Lansoprazole Quadru-ple Therapy for Helicobacter pylori positive duodenal ulcers: A ran-domized controlled study. Gastroenterology 2001;120(5):A582.

262. Tang V.S.Y., Wong W.M., Lam S.K., Lai K.C., Hu W.H.C., Wong B.C.Y. An Evaluation of Pyloritek Test for the Diagnosis of Helicobacter pylori Infection in Chinese – Before and After Eradication Therapy. Journal of Gastroenterology & Hepatology 2001;16 (Suppl.):A107.

263. Jiang Xiao-Hua, Lin M.C.M., Lam S.K., Kung H.F., Jiang Xi-Hu., Koki A.T., Masferrer J.L., Wong B.C.Y. Inhibition of Tumour Promoter-In-duced Activatior Protein 1 Activation and Cell Transformation by a Speicific COX-2 Inhibitor, SC236. Journal of Gastroenterology & Hepa-tology 2001;16 (Suppl.):A120.

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264. Lai K.C., Hu W.H.C., Hui W.M., Xia H.H.X., Lam S.K. Mechanism of Gas-tro-Oesophageal Reflux Disease (GORD) in Chinese. Journal of Gas-troenterology & Hepatology 2001;16 (Suppl.):A99.

265. Wong K.W., Wong W.M., Lam S.K., Li T.M., Cheung K.L., Fung F.M.Y., Xia H.H.X., Wong B.C.Y. Low Dose 13C-Urea Breath Test (13C-UBT) with Citrate is Equally Reliable for the Detection of Helicobacter pylori Infection in Chinese. Journal of Gastroenterology & Hepatology 2001;16 (Suppl.):A121.

266. Fung F.M.Y., Wong W.M., Lam S.K., Yee Y.K., Hung W.K., Yip W.C., Szeto M.L., Tong T.S.M., Lai K.C., Hu W.H.C., Yuen M.F., Hui C.K., Wong B.C.Y. Rabeprazole Based 3-Day and 7-Day Triple Therapy vs. 7-Day Omeprazole Based Triple Therapy for the Treatment of Heli-cobacter pylori Infection. Journal of Gastroenterology & Hepatology 2001;16 (Suppl.):A127.

267. Jiang X.H., Lam S.K., Tu S.P., Lin M.C.M., Kung H.F., Wong B.C.Y. Spe-cific COX-2 inhibitor suppresses anchorage-independent cell growth through AP-1/MAPK pathway in gastric cancer cells. Gastroenterology 2002;122 (4 Suppl 1):A3.

268. Chan A.O.O., Lam S.K., Wong B.C.Y., Hui W.M., Kwong Y.L. Methyla-tion of E-Cadherin gene in gastric cancer and in normal gastric mu-cosa from patients with and without Helicobacter pylori infection. Gastroenterology 2002;122 (4 Suppl 1):A238.

269. Jiang X.H., Lam S.K., Fan X.M., Lin C., Kung H.F., Wong B.C.Y. Specific COX-2 Inhibitor Suppresses NF-KB Activation by Inhibition of RelA/p65 Nuclear Translocation in Gastric Cancer. Gastroenterology 2002;122 (4 Suppl 1):A240.

270. Tu S.P., Jiang X.H., Lam S.K., Lin M.C.M., Kung H.F., Wong B.C.Y. Effect of Hydroxycampothecin and Arsenic Trioxide on Expression of IAP-Family Genes in Gastric and Colon Cancer Cells. Gastroenterology 2002;122 (4 Suppl 1):A243.

271. Gu Q., Wong W.M., Lam S.K., Lu H., Yin Y., Wang W.H., Fung F., Lai K.C., Xia H.H.X., Wong B.C.Y., Xiao S.D. One-Week Omeprazole, Fura-zolidone and Amoxycillin Rescue Therapy after Failure of Helicobacter pylori Eradication with Standard Triple Therapies. Gastroenterology 2002;122 (4 Suppl 1):A586.

272. Wong B.C.Y., Lam S.K., Wong W.M., Feng R., Zheng T.T., Yuen S.T., Ho J., Leung S.Y., Chen J.S., Lai K.C. Eradication of Helicobacter pylori Infection Significantly Slows Down the Progression of Precancerous Lesions in High Risk Population: a 5-Year Prospective Randomized Study. Gastroenterology 2002; 122 (4 Suppl 1):A588.

273. Wong B.C.Y., Lam S.K., Wong W.M., Zheng T.T., Chen J.S., Chen B.W., Lai K.C., Yuen S.T., Ho J. Eradicating Helicobacter pylori Infection in General Population Prevents Gastric Cancer: a 7-Year Prospective Randomized Placebo-Controlled Study. Gastroenterology 2002; 122 (4 Suppl 1):A588.

274. Wong W.M., Gu Q., Lam S.K., Fung F.M.Y., Lai K.C., Xia H.H.X., Hu W.H.C., Wong B.C.Y. Randomized Controlled Trial of Rabeprazole, Levofloxacin and Rifabutin Triple Therapy versus Rabeprazole-Based Quadruple Therapy as a Rescue Treatment after Failure of Helicobac-

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ter pylori (H. pylori) Eradication with Standard Triple Therapies. Gas-troenterology 2002; 122 (4 Suppl 1):A587.

275. Tu S.P., Lam S.K., Jiang X.H., Lin M.C.M., Kung H.F., Wong B.C.Y. Tar-geting survivin induced apoptosis and sensitized gastric and colon cancer cels to chemotherapy. Gastroenterology 2002; 122 (4 Suppl 1):A684.

276. Lam S.K. Recent Understanding on the Relationship between NSAID and H. pylori. Korean J Helicobacter Research & Practice 2002;2:248.

277. Lam S.K. Biologic Chemoprevention of Gastric Cancer. Korean J Gas-troenterol 2002;40(suppl 2):31-33.

278. Yang Y., Xia H.H.X., Lam S.K., Wong W.M., Lai K.C., Hu W.H.C., Chan C.K., Cheung H.K.L., Leung S.Y., Yuen S.T., Wong B.C.Y. Gastric ep-ithelial expression of trefoil family factor 2 and mucin 6 in normal and Helicobacter pylori infection subjects. HK Medical Journal 2003;9(1 Suppl):45.

279. Wong W.M., Gu Q., Lam S.K., Fung F.M.Y., Lai K.C., Hu W.H.C., Yee Y.K., Chan C.K., Xia H.H.X., Yuen M.F., Wong B.C.Y. Randomized con-trolled study of rabeprazole, levofloxacin and rifabutin triple therapy versus quadruple therapy as seond-line treatment of Helicobacter py-lori infection. HK Medical Journal 2003; 9(1 Suppl):46.

280. Wong W.M., Lam K.F., Hui W.M., Lai K.C., Hu W.H.C., Lam C.L.K., Wong N.Y.H., Xia H.H.X., Chan A.O.O., Lam S.K., Wong B.C.Y. A vali-dated symptoms questionnaire (Chinese-GORDQ) for the diagnosis of gastro-esophageal reflux disease in Chinese population. Hong Kong Med J 2003; 9(1 Suppl):48.

281. Wong W.M., Lam S.K., Hui W.M., Lai K.C., Chan C.K., Hu W.H.C., Xia H.H.X., Hui C.K., Yuen M.F., Chan A.O.O., Wong B.C.Y. Long term prospective followup of endoscopic esophagitis in southern Chinese prevalence and spectrum of the disease. Hong Kong Med J 2003;9(1 Suppl):48.

282. Wong W.M., Lam S.K., Cheung K.L., Tong T.S.M., Rozen P., Young G.P., Chu K.W., Ho J., Law W.L., Tung H.M., Choi H.K., Lee Y.M., Lai K.C., Hu W.H.C., Chan C.K., Yuen M.F., Wong B.C.Y. Evaluation of an automated immunochemical faecal occult blood test for colorectal neoplasia screening in a Chinese population. Hong Kong Med J 2003;9(1 Suppl):53.

283. Tu S.P., Cui J.T., Lin M.C.M., Jiang X.H., Yang Y., Lum C.T., Yuen S.T., Leung S.Y., Lam S.K., Kung H.F., Wong B.C.Y. Restoration of XAF1 ex-pression inhibits gastric and colonic tumorigenesis in vivo. Hong Kong Med J 2003;9(1 Suppl):54.

284. Xia H.H.X., He X.X., Lam S.K., Yang Y., Lin M.C.M., Wong W.M., Kung H.F., Leung S.Y., Yuen S.T., Wong B.C.Y. Increased serum levels and epithelial expression of macrophage migration inhibitory factor in gastric cancer. Hong Kong Med J 2003; 9(1 Suppl):54.

285. Wong W.M., Lam S.K., Hui W.M., Lai K.C., Hu W.H.C., Lam K.F., Lam C.L.K., Wong N.Y.H., Xia H.H.X., Chan A.O.O., Wong B.C.Y. Prevalence and clinical spectrum of gastroesophageal reflux disease in Chinese population a population based study. Hong Kong Med J 2003;9(1 Suppl):56.

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286. Lai K.C., Lam S.K., Wong B.C.Y., Cheung R, Hui W.M., Hu W.H.C., Wong W.M., Chan O.O. Eradication of H. pylori in Primary Prevention of Ulcer Complications Related to Low-Dose Aspirin Use. Gastroen-terology 2003; 124 (4 Suppl 1):723.

287. Wong W.M., Lam S.K., Hui W.M., Lai K.C., Hu W.H.C., Lam K.F., Lam C.L.K., Wong N.Y.H, Xia H.H.X., Chan A.O.O. Prevalence and Clinical Spectrum of Gastroesophageal Reflux Disease in Chinese Population – a Population Based Study. Gastroenterology 2003; 124 (4 Suppl 1):S1179.

288. Wong W.M., Lam S.K., Lam K.F., Hui W.M., Lai K.C., Hu W.H.C., Lam C.L.K., Wong N.Y.H., Xia H.H.X., Chan A.O.O., Wong B.C.Y. A validated symptom questionnaire (Chinese-GERDQ) for the diagnosis of gas-troesophageal reflux disease in Chinese population. Gastroenterology 2003; 124 (4 Suppl 1):T1649.

289. Tu S.P., Cui J.T., Jiang X.H., Yang Y., Lin M.C.M., Xu R., Lam S.K., Kung H.F., Wong B.C.Y. Gene Therapy for Colon Cancer Using Adeno-asso-ciated Virus Mediated Survivin Mutant. Gastroenterology 2003; 124 (4 Suppl 1):269.

290. Jiang X.H., Lam S.K., Lin M.C.M., Tu S.P., Cui J.T., Kung H.F., Wong B.C.Y. Antisense Targeting Protein Kinase C Alpha Inhibit Gastric Car-cinogenesis in Vivo. Gastroenterology 2003; 124 (4 Suppl 1):S1272.

291. Jiang X.H., Lin M.C.M., Lam S.K., He H., Tu S.P., Kung H.F., Wong B.C.Y. Nonsteroidal Anti-Inflammatory Drugs Inhibit Human Telom-erase Reverse Transcriptase (hTERT) in Gastric and Colon Cancer. Gastroenterology 2003; 124 (4 Suppl 1):M991.

292. Tu S.P., Cui J.T., Lin M.C.M., Jiang X.H., Yang Y., Lum C.T., Yuen S.T., Leung S.Y., Lam S.K., Kung H.F., Wong B.C.Y. Restoration of XAF1 Ex-pression Inhibits Gastric and Colonic Tumorigenesis in vivo. Gastroen-terology 2003; 124 (4 Suppl 1):M1026.

293. Yang Y., Xia H.H.X., Talley N., Zhang G.S., Wyatt J.M., Stuart A., Che-ung K., Lam S.K., Wong B.C.Y. Antralization of Gastric Incisura is To-pographically Associated with Increased Gastric Epithelial Apoptosis and Proliferation, but not with CagA Seropositivity. Gastroenterology 2003; 124 (4 Suppl 1):T995.

294. Cheng C., Chan A.O.O., Hui W.M., Lam S.K. Coping Strategies, Illness Perception, Anxiety, and Depression of Patients with Idiopathic Con-stipation: A Population-based Study. Gastroenterology 2003; 124 (4 Suppl 1):T1412.

295. He X.X., Xia H.H.X., Yang Y., Lam S.K., Lin M.C.M., Wong W.M., Kung H.F., Leung S.Y., Yuen S.T., Zhao Y.H., Wong B.C.Y. Increased Serum Levels and Epithelial Expression of Macrophage Migration Inhibitory Factor in Gastric Cancer. Gastroenterology 2003; 124 (4 Suppl 1):T1728.

296. Yang Y., Xia H.H.X., Lam S.K., Wong W.M., Leung S.Y., Yuen S.T., Elia G., Wright N., Wong B.CY. Helicobacter pylori Infection is Associated with Aberrant Expression of Trefoil Family Factor 2 and Mucin 6 in Gastric Antrum, Incisura and Body. Gastroenterology 2003; 124 (4 Suppl 1):W889.

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297. He X.X., Xia H.H.X., Yang Y., Lam S.K., Lin M.C.M., Wong W.M., Kung H.F., Ogura K., Berg D.E., Zhao Y.H., Wong B.C.Y. Macrophage Migra-tion Inhibitory Factor Released by Monocytes after Co-Culture with Helicobacter pylori Increases Proliferation of Gastric Epithelial Cells. Gastroenterology 2003; 124 (4 Suppl 1):W920.

298. Chan A.O.O., Chu K.M., Lam S.K., Wong B.C.Y., Kwok K.F., Law S., Hui W.M., Yueng Y.H., Wong J. Soluble E-Cadherin is an Independent Pre-therapeutic Factor for Long Term Survival in Gastric Cancer. Gas-troenterology 2003; 124 (4 Suppl 1):W1357.

299. Lam S.K. , Wong B.CY. The Role of Cyclooxygenase in Gastrointestinal Diseases. Journal of Gastroenterology & Hepatology 2003;18(Suppl):A5.

300. Chan A.O.O., Lam S.K., Wong B.C.Y., Hui W.M., Kwong Y.L. Methyla-tion of E-cadherin gene in gastric cancer and in normal gastric mu-cosa from patients with and without Helicobacter pylori infection. Journal of Gastroenterology & Hepatology 2003;18(Suppl):A27.

301. Chan A.O.O., Wong B.C.Y., Lan H.Y., Loke S.L., Chan W.K., Hui W.M., Yuen Y.H., Ng I., Hou L., Wong W.M., Yuen M.F., Luk J.M.C., Lam S.K. Deregulation of E-cadherin-catenin complex in precancerous lesions of gastric adenocarcinoma. Journal of Gastroenterology & Hepatology 2003;18(Suppl):A27.

302. Chan A.O.O., Chu K.M., Lam S.K., Wong B.C.Y., Kwok K.F., Law S., Hui W.M., Yueng Y.H., Wong J. Soluble E-cadherin is an independent pretherapeutic factor for long-term survival in gastric cancer. Journal of Gastroenterology & Hepatology 2003;18(Suppl):A27

303. Tu S.P., Cui J.T., Jiang X.H., Xu R., Lin M.C.M., Lam S.K., Zou B., Jiang S.H., Kung H.F., Wong B.C.Y. Gene therapy using adeno-associated virus-mediated survivin antisense inhibtis angiogenesis and tumor growth in colon cancer. Journal of Gastroenterology & Hepatology 2003;18(Suppl):A60.

304. Xia H.H.X., He X.X., Yang Y., Lam S.K., Gu Q., Lin M.C.M., Wong W.M., Kung H.F., Ogura K., Berg D.E., Zhao Y.H., Wong BCY. Macrophage migration inhibitory factor released by monocytes after co-culture with Helicobacter pylori stimulates proliferation of gastric epithelial cells. J Gastroenterol Hepatol 2003;18 (Suppl.):B116.

305. Yang Y., Xia H.H.X., Lam S.K., Wong W.M., Cheung H.K.L., Leung S.Y., Yuen S.T., Elia G., Wright N.A., Wong B.C.Y. Aberrant epithelial ex-pression of trefoil family factor 2 and mucin 6 in Helicobacter pylori-infected gastric antrum, incisura and body a useful marker for antral-ization. J Gastroenterol Hepatol 2003;18 (Suppl.):B108.

306. Yang Y., Lin M.C.M., Ching Y.P., Lam S.K., Xia H.H.X., Tu S.P., Zou B., Wang J.D., Li G.Q., He H., Gu Q., Peng J.Z., Kung H.F., Wong B.C.Y. FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis. Gastroen-terology 2004; 126 (4 Suppl 2):S938.

307. Wang J.D., Gu Q., Xia H.H.X., Tu S.P., Peng J.Z., Yang Y., Zou B., Lin M.C.M., Kung H.F., Lam S.K., Wong B.C.Y. JNK1 Up-Regulates the Ex-pression of XIAP-Associated Factor 1 (XAF1) by a P53-Dependent Pathway in Gastrointestinal Cancer. Gastroenterology 2004; 126 (4 Suppl 2):M946.

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308. Zou B., Lin M.C.M., Lam S.K., Tu S.P., Yang Y., Wang J.D., He H., Peng J.Z., Kung H.F., Wong B.C.Y. Hypermethylation Status Around Exon 1 of XIAP-Associated Factor 1 in Human Gastric and Colon Cancer Cell Lines. Gastroenterology 2004; 126 (4 Suppl 2):T981.

309. Tu S.P., Chan A.O.O., Lin M.C.M., Jiang X.H., Lam S.K., Kung H.F., Wong B.C.Y. Livin, a Novel Member of Inhibitor of Apoptosis, Is Marker of Poor Prognosis in Gastric Cancer. Gastroenterology 2004; 126 (4 Suppl 2):T1256.

310. Li G.Q., Xia H.H.X., Chen M.H., Peng J.Z., Gu Q., Cui J.T., Cho C.H., Lam S.K., Lin M.C.M., Berg D.E., Feng Z.H., Langenbach R., Kung H.F., Wong B.C.Y. Cyclooxygenase-2 Gene Disruption Enhances Gastric In-flammation but Inhibits Gastric Epithelial Proliferation Induced by H. pylori Infection. Gastroenterology 2004; 126 (4 Suppl 2):W907.

311. Chan A.O.O., Peng J.Z., Lam S.K., Hui W.M., Wong W.M., Yuen M.F., Kwong Y.L., Rashid A., Wong B.C.Y. Reveral of E-Cadherin Promoter Hypermethylation Status after Helicobacter pylori Eradication. Gas-troenterology 2004; 126 (4 Suppl 2):333.

312. Wong W.M., Lai K.C., Hui W.M., Hu W.H.C., Huang J.Q., Wong N.Y.H., Xia H.H.X., Chan A.O.O., Lam S.K., Wong B.C.Y. Pathophysiology of Gastro-oesophageal Reflux Diseases in Chinese – Role of Transient Lower Oesophageal Sphincter Relaxation and Oesophageal Motor Dysfunction. Gastroenterology 2004; 126 (4 Suppl 2):T1724.

313. Li G.Q., Xia H.H.X., Chen M.H., Chan A.O.O., Cho C.H., Lam S.K., Berg D., Feng Z.H., Langenbach R., Wong B.C.Y. Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced inflamma-tion, apoptosis and proliferation. Journal of Gastroenterology & Hepa-tology 2004; 19(Suppl.):A299.

314. Xia H.H.X., Li G.Q., Chen M.H., Chan A.O.O., Cho C.H., Lam S.K., Berg D., Feng Z.H., Langenbach R., Wong B.C.Y. Cyclooxygenase-1 and -2 gene disruption potentiate TH1 polarization in response to Helicobac-ter pylori. Journal of Gastroenterology & Hepatology 2004; 19(Suppl.):A366.

315. Wang J.D., Zou B., Gu Q., Jiang B., Zhuang Z.H., Xia H.H.X., Lin M.C., Lam S.K., Kung H.F., Wong B.C.Y. Down-Regulation of XAF1 Expres-sion by its Interacting Protein FHL2 via p53-Mediated Transcription Regulation. Gastroenterology 2005; 128 (4 Suppl 2):A-105.

316. Wang J.D., Gu Q., He H., Jiang B., Zhuang Z.H., Xia H.H.X., Lin M.C., Lam S.K., Kung H.F., Wong B.C.Y. Down-Regulation of XIAP Associated Factor 1 (XAF1) through Hsf-1 Binding in the Promoter Region. Gas-troenterology 2005; 128 (4 Suppl 2):A-105.

317. Lai K.C., Hui W.M., Wong B.C.Y., Hu W.H.C., Chan A.O.O., Lam S.K. Lansoprazole but not Rofecoxib Reduced Dyspeptic Symptoms of Pa-tients on NSAIDs. Gastroenterology 2005; 128 (4 Suppl 2):A-24.

318. Xia B., Xia H.H.X., Lam S.K., Chan A.O.O., Lai K.C., Hu W.H.C., Wong B.C.Y. Trends in Prevalence of Peptic Ulcer Disease and Helicobacter pylori Infection and Frequency of NSAID Intake in General Practi-tioner-Referred Dyspeptic Patients over 6 Years in Hong Kong. Gas-troenterology 2005; 128 (4 Suppl 2):A-230.

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319. Zhuang Z.H., Tsao G.S., Xia H.H.X., He H., Chan A.O.O., Lam S.K., Wong B.C.Y. COX-2 Inhibition Induces Apoptosis in Human Esophageal Epithelial Cells: Implication for Chemoprevention. Gas-troenterology 2005; 128 (4 Suppl 2):A-299.

320. Chan A.O.O., Chu K.M., Sun Y.W., Cheung H.K.L., Lam S.K., Yuen M.F., Hui W.M., Wong B.C.Y. The Association between Interleukin 1 Beta Polymorphism and Hypermethylation at Tumor Suppressor Genes in Gastric Cancer. Gastroenterology 2005; 128 (4 Suppl 2):A-399.

321. Zhu S.L., Xia H.H.X., Lam S.K., Yu L.F., Yang Y., Sun Y.W., Wang J.D., Chan A.O.O., Wong B.C.Y. Alterations of Gastric Homeoprotein Ex-pression in H. pylori Infection and/or Intestinal Metaplasia. Gastroen-terology 2005; 128 (4 Suppl 2):A-598.

322. Chan A.O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong T.S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu W.H.C., Yuen M.F., Lau Y.K., Lee S., Lam S.K., Wong B.C.Y. Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Anal-ysis of a Prospective Study. Gastroenterology 2006; 130 (4 Suppl 2):A-36.

323. Chan A.O.O., Hui W.M., Lam K.F., Leung G., Hu W.H.C., Chan C.K., Yuen M.F., Lam S.K., Wong B.C.Y. The Clinical Characteristics of Pa-tients with Idiopathic Constipation wiht a Positive Family History. Gas-troenterology 2006; 130 (4 Suppl 2):A-158.

324. Chan A.O.O., Hui W.M., Hu W.H.C., Leung G., Chan C.K., Yuen M.F., Lam S.K., Wong B.C.Y. Familial Aggregation in Constipated Subjects in a Tertiary Referral Center. Gastroenterology 2006; 130 (4 Suppl 2):A-159.

325. Chan A.O.O., Hui W.M., Chan C.K., Lai K.C., Hu W.H.C., Yuen M.F., Wong W.M., Lau G.K.K., Hui C.K., Lam S.K., Wong B.C.Y. Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening. Gastroenterology 2006; 130 (4 Suppl 2):A-618.

326. Chan A.O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A., Wong B.C.Y. Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation. Gastroenterology 2006; 130 (4 Suppl 2):A-717.

327. Tang L.P., Cho C.H., Hui W.M., Huang C., Lai C.L., Xia H.H.X., Lam S.K., Rashid A., Wong B.C.Y., Chan A.O.O. A Negative Correlation be-tween IL-6 and DNA Methylation in Patients with Gastric Cancer. Gas-troenterology 2006; 130 (4 Suppl 2):A-717.

328. Chan A.O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Wong S.Y., Hui W.M., Lam S.K., Wong B.C.Y. Aspirin does not Prevent Recur-rence of Colorrectal Adenomas in Patients with Coronary Artery Dis-ease. Gastroenterology 2007;132 (4 Suppl 2):A194.

329. Chan A.O.O., Hui W.M., Leung Y.C., Wong Y.H., Chan P., Hung I.F.H., Hsu A., But D., Lam S.K., Wong B.C.Y. Better Efficacy of Tegaserod in Constipated Patients with Slow Colonic Transit, Absent Pelvic Floor Dyssynergy and Absent Impaired Rectal Sensation. Gastroenterology 2007;132 (4 Suppl 2):A194.

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330. Chan A.O.O., Chow R., Hui W.M., Leung Y.C., Tong S.M., Lam S.K., Wong B.C.Y., Biofeedback is Equally Effective in Patients with Short or Long Duration of Function Constipation. Gastroenterology 2007;132 (4 Suppl 2):A194.

331. Chan A.O.O., Hui W.M., Wong Y.H., Leung Y.C., Lam S.K., Wong B.C.Y. Decreased Cortical Activation during Rectal Distention in Patients with Functional Constipation with Normal Rectal Compliance. Gas-troenterology 2007;132 (4 Suppl 2):A23.

332. Chan A.O.O., Hui W.M., Leung Y.C., Hu H.C., Lam S.K., Wong B.C.Y. Efficacy of Tegasered for Functiona Constipation in Chinese Subjects: A Randomized Double Blind Contolled Trial in a Single Center. Gas-troenterology 2007;132 (4 Suppl 2):A194.

333. Chan A.O.O., Huang C.Y., Leung Y.C., Hui W.M., Lam S.K., Wong B.C.Y. Familial Constipationis Associated with a2 Adrenoceptor Polymor-phism. Gastroenterology 2007; 132 (4 Suppl 2):A189.

334. Chan A.O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Wong S.Y., Hui W.M., Chan C.K., Lai K.C., Cheung T.K., Chan P., Wong G., Yuen R.M.F., Lau Y.K., Lee S.W.L., Seto M.L., Lam S.K., Wong B.C.Y. Patients with Coronary Artery Disease had High Prevalanece of Col-orectal Cancer and Adenoma: END-Results of Metabolic Syndrome and Smoking. Gastroenterology 2007;132 (4 Suppl 2):A65.

335. Chan A.O.O., Loo C.K., Leung C.M., Wong S.Y., Ng F.H., Li M.K.W., Lam K.M., Lam S.K., Wong B.C.Y. Prevalence of Colonic Lesions after a Negative Screening Colonscopy in a Population with Rapidly Rising Colorectal Cancer Incidence: A Prospective Multi-Center Analysis. Gastroenterology 2007;132 (4 Suppl 2):A189

336. Cheung T.K., Lam B., Ip M.S.M., Wong Y.H., Chan A.O.O., Lam S.K., Wong B.C.Y., Nocturnal Reflux Symptoms Correlate with Respiratory Events in Patients with Obstructive Sleep Apnea. Gastroenterology 2007;132 (4 Supp 2):A482.

337. Lam T.J., Mulder C.J.J., Peña S., Wong B.C.Y., Hui W.M., Lam S.K., Chan A.O.O. Increased in Prevalence of Advanced Colonic Polyps in Young Patients over the Past Eight Years in Hong Kong. Gastroenterology 2007;132 (4 Suppl 2):A195.

Book Reviews, Journal Correspondence, Newspaper Editorials

1. Lam S.K . A plea to include a placebo group in ulcer trials. Gastroen-terology 1983; 85: 983.

2. Lam S.K . Prostaglandins, smoking, and duodenal ulcers. Lancet 1987;1:212-213.

3. Lam S.K . Book review. Viral Hepatitis, Clinical Gastroenterology Monograph Series, Koff RS, Wiley J and Sons, New York, 1978. Mod-ern Medicine of Asia, 1980; 16: 71.

4. Lam S.K . Antrectomy and maximal acid output. Gastroenterology 1980; 79: 181-2.

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5. Lam S.K . Acid output and ulcer healing. Gastroenterology 1982; 82: 166.

6. Cheung BMY, Lam S.K. Is there a role for antacids in the modern man-agement of peptic ulcers? Expert Opinion on Investigational Drugs 1996; 5: 345-53.

7. Lam S.K . Medical students reductions are a short-sighted solution. South China Morning Post 2001; February 19.

8. Lam S.K . 減少醫生數目-政府短視. Ming Pao 2001; April 9.9. Lam S.K . Phone row a loss to society. South China Morning Post 2001;

May 2.10. Lam SK . Hong Kong will slip further behind without more research

funds. South China Morning Post 2002; September 26.11. Lam SK . Winning and losing: the fight against Sars. South China

Morning Post 2003; April 19.12. Lam S .K. Health Care: Hong Kong-Asia’s biomedical hub? South China

Morning Post 2004; February 10.13. Lam S.K . Stop the finger-pointing. South China Morning Post 2004;

March 31.14. Lam S.K . SARS Investigation: Review doctors’ performance, too.

South China Morning Post 2004; August 5.15. Lam S.K . Asia’s Health-Care Hub: Unleash Hong Kong’s healing

power. South China Morning Post 2004; November 24.16. Lam S.K . Unchain Our Medical Schools. South China Morning Post

2006; February 3.17. Lam S.K . Asia’s Health-Care Hospital. South China Morning Post 2006;

Februrary 16.18. Lam S.K . 發展生物科技中心，創醫學院新天. Sing Tao Daily 2006; March

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· web views first gastric cancer chemoprevention population study, conducted for over ten years...

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