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Delegate Program

IFPA is striving towards a paperless society. We hope you enjoy the first electronic program for IFPA.

IFPA Meeting 2013 September 11 – 14, 2013 Whistler, British Columbia, Canada 2

We gratefully acknowledge our generous sponsors…


Table of Contents

1. Our Sponsors 2

2. Program‐at‐a‐Glance 4

3. Workshops‐at‐a‐Glance 5

4. Committees 6

5. Welcome from the IFPA President 12

6. Welcome from the 2013 Conference Organizing Chair 13

7. General Information 14

8. Business Meeting Schedule 16

9. Social Program Schedule 18

10. Full Program ‐‐ Wednesday September 11, 2013 19‐20

Thursday September 12, 2013 20‐23

Friday September 13, 2013 23‐25

Saturday September 14, 2013 25‐28

11. Invited Speaker Biographies 29‐39

12. IFPA Meeting 2013 Abstracts not printed in PLACENTA 40‐42

13. Appendix A – Workshop Program 43

14. Appendix B ‐ New Investigator Oral Sessions 58

15. Appendix C ‐ Poster Session 1 61

16. Appendix D – Poster Session 2 75

17. New Investigator Travel Awards 2013 90

18. IFPA Awards 92

19. Delegate Statistics 94

20. Delegate List 95

21. IFPA 2014 99


Program at a Glance

Tuesday September

10, 2013 Wednesday

September 11, 2013 Thursday September

12, 2013 Friday September 13,

2013 Saturday September

14, 2013

7:00 Breakfast (7:00 - 8:30) Breakfast (7:00 - 8:30) Breakfast (7:00 - 8:30)

7:30

Awards Committee (7:30 - 8:30)

Placenta Editorial Board (7:30 - 8:30)

Awards Committee (7:30 - 8:30) 8:00

8:30

Plenary 2 (8:30-10:30)

Workshops 2 (8:30 - 10:30)

Coffee outside

Plenary 4 (8:30 - 10:30)

9:00 IFPA Executive Meeting (9:00 - 12:00) 9:30

10:00

Registration Grand Foyer Whistler Conference

Centre (10:00 - 12:00)

10:30 Coffee Break (10:30-11:00)

TR Award (10:30-11:00)

Coffee Break (10:30-11:00)

11:00

NI Oral Session 1 (11:00 - 12:15)

NI Oral Session 2 (11:00 - 12:00)

NI Oral Session 3 (11:00 - 12:00) 11:30

12:00

Lunch Lunch & ECR Session Lunch on your own Final Poster Juding

Awards

12:30 (12:15-1:00) (12:00-1:00) (12:00-1:00)

13:00

Registration Grand Foyer Whistler Conference Centre (1:00 - 3:00)

Plenary 3 (1:00 - 3:00) Plenary 5

(1:00 - 3:00)

13:30 Workshops 1

14:00

Registration Lobby of Crystal Lodge Hotel

(2:00 - 4:00)

(1:00-3:00)

14:30

15:00

15:30 Posters 1 Coffee Break (3:00 - 5:00)

Posters 2 Coffee Break (3:00 -5:00)

Workshops 3 (3:00 - 5:00)

Coffee outside 16:00 Welcome (4:00-4:30)

16:30

IFPA Executive Meeting (4:30-6:30)

Keynote and Plenary 1 (4:30 - 6:30)

17:00 IFPA Placentology Award NI Organized Debate (5:00 - 6:00)

IFPA Senior Award

17:30 (5:00-5:45) (5:00 - 5:45)

18:00 IFPA Business Meeting Regional Business

Meetings Free Time

18:30 (5:45-6:15) (6:00-6:30)

19:00

IFPA Executive Dinner (6:30 - 9:30)

Free Time Free Time Free Time

19:30

Opening Reception (LOKE and NIH Awards)

(7:30 - 9:30)

Dinner on your own ECR Social (7:30 - 9:30)

21 Steps Kitchen/Bar St. Andrew's House Main

Village The Amazing IFPA Race

(8:00)

Dinner and performance at the Squamish Lil’wat

Cultural Centre (7:30-10:30)

GALA Dinner (7:30 - 8:00 reception)

(8:00 - 1:00am - dinner/dancing and

awards)

20:00

20:30

21:00

21:30

Executive meetings in dark blue are by invitation only

Speaker ready room 9am - 11am & 2pm - 4pm





Workshops-at-a Glance Note: Workshops will take place in the following rooms: Whistler Conference Centre Sea to Sky Ballroom A (upper level); Garibaldi A, Garibaldi B, Fitzsimmons

(lower level) and will be assigned according to participant numbers.

Workshop 1 Date: Thursday, September 12, 2013 Time: 1:00pm – 3:00pm

1.1 Diabetes in pregnancy: New insight into signalling pathways and regulators

Co-Chairs: Lopa Leach (Nottingham, UK) and Gernot Desoye (Graz, Austria)

1.2 Use of “omics” in understanding placental development and pathologies

Sponsored by the Hospital for Sick Children

Co-Chairs: Greg Rice (Brisbane, Australia) and Martin Post (Toronto, Canada)

1.3 Dual ex vivo perfusion of an isolated cotyledon of human placenta

Co-Chairs: Paul Brownbill (Manchester, UK), Stefan Hansson (Lund, Sweden) and Henning Schneider (Bern, Switzerland)

1.4 Maternal placental immunological interactions: Advances in the field

Co-Chairs: Caroline Dunk (Toronto, Canada) and Michelle Letarte (Toronto, Canada)

Workshop 2 Date: Friday, September 13, 2013 Time: 8:30 am – 10:30 am

2.1 Planning and coordination of a Placenta Research Network

Co-Chairs: Sally Collins (Oxford, UK) and Stacy Zamudio (Hackensack, USA)

2.2 Novel determinants of trophoblast cell fate

Co-Chairs: Andrea Jurisicova (Toronto, Canada) and Sascha Drewlo (Detroit, USA)

2.3 Maternal dyslipidemia in pregnancy: Effects on placental function and fetal growth

Co-Chairs: Theresa Powell (San Antonio, USA) and Vicki Clifton (Adelaide, Australia)

2.4 Oxygen in placental development and pathologies

Co-Chairs: Alessandro Rolfo (Turin, Italy) and Charles Graham (Kingston, Canada)

Workshop 3 Date: Saturday, September 14, 2013 Time: 3:00-5:00 pm

3.1 Placental imaging: Insights into current and future modalities

Co-Chairs: Andrée Gruslin (Ottawa, Canada) and Tullia Todros (Turin, Italy)

3.2 Stem cells: From biology to pathology

Sponsored by Insception Biosciences Co-Chairs: Bill Kalionis (Melbourne, Australia) and Mohamed Abumaree (Riyadh, Saudi Arabia)

3.3 Bioinformatics tools for gene expression analysis

Co-Chairs: Douglas Kniss (Columbus, US) and Brian Cox (Toronto, Canada)

3.4 Evolutionary approaches to understanding preeclampsia: The view from the placenta

Co-Chairs: Derek Wildman (Detroit, USA) and Anthony Carter (Odense, Denmark)


Committees International Federation of Placenta Associations Webpage IFPA: http://www.ifpafederation.org/home/home.html

Executive Committee:

Australian & New Zealand Placenta Research Association Dr. Larry Chamley Dr. Peter Mark Dr. Padma Murthi Dr. Claire Roberts (Treasurer of IFPA) (Alternate Dr. Vicki Clifton) European Placenta Group Dr. Danièle Evain Brion Dr. Fiona Lyall Dr. Christiane Pfarrer (Secretary of IFPA) Dr. Colin Sibley (Alternate Dr. Annetine Staff) Japan Placenta Association Dr. Norimasa Sagawa Dr.Yoshiki Kudo Dr. Sigeru Saito Dr. Masaomi Takayama Placenta Association of the Americas Dr. Denise Hemmings Dr. Thomas Jansson Dr. Nick Illsley (President of IFPA) Dr. Aureo Yamada (Alternate Dr. Estela Bevilacqua) Co-opted, non- voting members Journal Editors Dr. Graham Burton (Placenta) Dr. Anthony Carter (Trophoblast Research) Dr. Vicki Clifton (Placenta) Dr. Yoel Sadovsky (Placenta) Early Career Researcher Representatives Dr. Sally Collins (UK) Dr. Carlos Salomon (Australia) Publications Committee Chair Dr. Les Myatt Webmaster Dr. Alessandro Rolfo Awards Committee Chair(s) Dr. Martin Knöefler (2008 - 2013) Dr. Estela Bevilacqua (2013 - 2017)

http://www.ifpafederation.org/home/home.html

mailto:[email protected]

mailto:






















National Scientific Committee

Thank you to those who helped judge our New Investigator Awards.

Isabella Caniggia MD, PhD, Conference Chair University of Toronto, Toronto, Ontario, Canada S. Lee Adamson PhD University of Toronto, Toronto, Ontario, Canada Jean François Bilodeau, PhD Université Laval, Québec City, Québec, Canada Alan Bocking, MD University of Toronto, Toronto, Ontario, Canada John Challis PhD University of Toronto, Toronto, Ontario, Canada Brian Cox, PhD University of Toronto, Toronto, Ontario, Canada Jay Cross DVM PhD University of Calgary, Calgary, Alberta, Canada Anne Croy DVM, PhD Queen’s University, Kingston, Ontario, Canada Sandy Davidge PhD University of Alberta, Edmonton, Alberta, Canada Caroline Dunk PhD University of Toronto, Toronto, Ontario, Canada William Gibb PhD University of Ottawa, Ottawa, Ontario, Canada Charles Graham PhD Queen's University, Kingston, Ontario, Canada Andrée Gruslin MD, FRCSC University of Ottawa, Ottawa, Ontario, Canada Denise Hemmings PhD University of Alberta, Edmonton, Alberta, Canada Andrea Jurisicova PhD University of Toronto, Toronto, Ontario, Canada Sarah Keating MD University of Toronto, Toronto, Ontario, Canada


John Kingdom MD University of Toronto, Toronto, Ontario, Canada Line Leduc MD, FRCSC, DABOG (MFM) Université de Montréal, Montréal, Québec, Canada Michelle Letarte PhD University of Toronto, Toronto, Ontario, Canada Peter Leung PhD Univery of British Columbia, British Columbia, Canada Stephen Lye PhD University of Toronto, Toronto, Ontario, Canada Daniel MacPhee Ph.D University of Saskatchewan, Saskatoon, Saskatchewan, Canada Stephen Matthews PhD University of Toronto, Toronto, Ontario, Canada Don Morrish MD, PhD, FRCPC University of Alberta, Edmonton, Alberta, Canada Ori Nevo MD University of Toronto, Toronto, Ontario, Canada Chun Peng PhD York University, Toronto, Ontario, Canada Tim Regnault PhD Western University, London, Ontario, Canada Wendy Robinson PhD University of British Columbia, Vancouver British Columbia, Canada John Sled PhD University of Toronto, Toronto, Ontario, Canada Rima Slim PhD McGill University, Montréal, Québec, Canada Debbie Sloboda PhD McMaster University, Hamilton, Ontario, Canada T.C Tai PhD Laurentian University, Sudbury, Ontario, Canada Rosanna Weksberg MD, PhD University of Toronto, Toronto, Ontario, Canada


Kaiping Yang PhD Western University, London, Ontario, Canada

International Scientific Committee Thank you to those who helped judge our New Investigator Awards.

Estela Bevilacqua PhD University of São Paulo, São Paulo, Brazil Graham Burton MD, DSc, FMedSci University of Cambridge, Cambridge, UK Anthony Carter PhD University of Southern Denmark, Denmark Larry Chamley PhD The University of Auckland, Auckland, New Zealand Vicki Clifton PhD The University of Adelaide, Adelaide, Australia Gernot Desoye PhD Medical University of Graz, Graz, Austria Danièle Evain-Brion MD, PhD NSERM University Paris Descartes, Paris, France Berthold Huppertz PhD Medical University of Graz, Graz, Austria Nick Illsley DPhil Hackensack University Medical Center, Hackensack, New Jersey, USA Thomas Jansson MD, PhD University of Texas Health Science Center San Antonio, San Antonio, Texas, USA Dr. Rebecca Jones PhD University of Manchester, Manchester, UK Martin Knöfler PhD Department of Obstetrics and Fetal-Maternal Medicine, Reproductive Biology Unit, Vienna, Austria Yoshiki Kudo MD, PhD Hiroshima University, Hiroshima, Japan Lopa Leach PhD University of Nottingham, UK Fiona Lyall PhD University of Glasgow, Scotland


Padma Murthi MSc, MPhil, PhD University of Melbourne, Melbourne, Australia Les Myatt PhD University of Texas Health Science Center San Antonio, San Antonio, Texas, USA D. Michael Nelson MD, PhD Washington University School of Medicine, Washington DC, USA Christiane Pfarrer DVM, PhD Affiliation University of Veterinary Medicine Hannover, Germany Christopher Redman MD University of Oxford, Oxford, UK Gregory Rice PhD The University of Queensland, Queensland, Australia Claire Roberts PhD University of Adelaide, Adelaide, Australia Alessandro Rolfo PhD University of Turin, Turin, Italy Yoel Sadovsky MD University of Pittsburgh, Pittsburgh, Pennsylvania, USA Annetine Staff MD, PhD Oslo University Hospital, Oslo, Norway Tullia Todros MD University of Turin, Turin, Italy Melissa Westwood PhD University of Manchester, Manchester, UK Aureo Yamada PhD University of Campinas, Campinas, Brazil Stacy Zamudio PhD Hackensack University Medical Center, Hackensack, New Jersey, USA


Judging Committees:

Posters:

Co-Chairs: Theresa Powell and Larry Chamley Anne Croy Marc Baumann Mark Dilworth Qi Chen Vicki Clifton Sascha Drewlo Marijke Faas Charles Graham Lynda Harris Denise Hemmings Jo James Thomas Jansson Helen Jones Rohan Lewis Donald Morrish Padma Murthi Perrie O'Tierney-Ginn Gregory Rice Claire Roberts John M. Robinson Wendy Robinson Sicco Scherjon Annetine Staff Stephen Tong Orals: Co-Chairs: Martin Knöfler and Estela Bevilacqua Derek Wildman Jo James TBD TBD


Welcome from the IFPA President Dear Colleagues and Friends,

I am delighted to welcome you to the 2013 meeting of the International Federation of Placenta

Associations, hosted by the Placenta Association of the Americas in Whistler, British Columbia, Canada,

the 19th annual meeting of IFPA. Dr. Isabella Caniggia and her colleagues have done extraordinary work,

identifying crucial scientific areas of interest and engaging keynote and plenary speakers and workshop

Chairs to present timely, state-of-the-art science. This meeting will present a broad sweep of excellent

placental and perinatal science combined with a superb location that all of you will enjoy. We are

continuing our efforts to promote early- and mid-career researchers with travel awards and special

sessions for both groups. In addition to the formal scientific sessions I hope that the workshops and

social events, including the first Great IFPA Race, will provide venues where researchers at all levels of

experience can mix and interact. It is this interaction which is the heart of our meetings and is most

important to our continued vitality. For this reason I encourage everyone attending to join in the

proceedings, to ask questions, to share your experience and expertise and to participate in the

friendship and excitement that is IFPA2013.

Yours sincerely,

Nicholas Illsley D.Phil.

President, IFPA


Welcome from the 2013 Conference Organizing Chair

Dear Colleagues:

I can’t believe it’s finally here! This conference has been in preparation for two years and has been in

my thoughts waking and sleeping. I have worked with many wonderful people and I am so happy that

those in the Society who I called upon were so willing to lend their expertise and assistance. My team

and I, with Nick Illsley’s invaluable assistance, have fashioned what I hope you will find to be a meeting

with the most excellent and up-to-the minute research in the field of placenta research.

We all love the science, but I hope you will also love Whistler and the opportunities it provides to enjoy

a beautiful piece of Canada, il mio paese adottivo. There are endless opportunities of every kind – you

can enjoy nature, you can exercise, you can relax, and you can dine and socialize to your heart’s content.

I hope you will do all these things, in the best company, those who, like you, have a passion for research

on the placenta and obstetrical care.

Thank you to all of you for your participation and grazie mille to our generous sponsors. In difficult

times it is good to know that there are those who give generously to causes that make a difference.

A hearty welcome to all our Delegates, both seasoned veterans and New Investigators, to those who

have come before and to those who, I hope, will make it a habit to attend.

Let’s make Whistler stand for a shining moment in placenta research. Enjoy IFPA 2013!

I miei migliori saluti,

Isabella Caniggia MD, PhD

Chair, IFPA 2013


General Information

Please see our meeting website for information on activities and tour options, latest news and anything else to do with IFPA 2013. http://www.ifpa2013.ca/

Conference Registration / Information Desk The main registration desk is located in the Whistler Conference Centre Grand Foyer. There will be someone available at the registration desk throughout the conference to assist you. Registration times and location: Tuesday September 10th – 2:00pm – 4:00pm Crystal Lodge Suites – Foyer Wednesday, September 11th - 10:00am - 12:00pm and 1:00pm - 3:00pm Whistler Conference Centre – Grand Foyer Thursday, September 12th – 8:00am – 12:00pm and 1:00pm - 3:00pm Whistler Conference Centre – Grand Foyer

Hotel reception

The hotel reception desk at The Crystal Lodge & Suites and the Aava Hotel will be open for the whole meeting, assisting you with room and hotel facility inquiries, as well as any inquiries regarding activities.

Conference materials A delegate bag will be given to every scientific delegate at registration.

This bag contains conference material, including the USB key with the delegate manual and the final meeting programme (with speaker details as well as workshop programmes), venue information and general information about Whistler, and the PLACENTA meeting issue with abstracts and presenting author names. Any additional abstracts will be found in the electronic files on the USB key.

Conference catering All meals are provided with your conference registration, with the exception of Dinner on Thursday, September 12 and Lunch on Saturday, September 14. We hope you will take this opportunity to explore the many places to eat in Whistler Village, located just outside the Conference Centre.

Badges, meals Please ensure that you wear your conference badge throughout the conference. This will give you access to all sessions and meals included in the conference. Spouses or significant others are welcome to join you for the social events upon purchase of a social event package at a cost of $200 (includes the Opening Reception, Dinner and Performance at the Squamish Lil’wat Cultural Centre and the Gala Dinner) online or at the registration desk by major credit card only. Program Any last minute changes to the program will be indicated on the digital screen in the Grand Foyer at the Conference Centre.

http://www.ifpa2013.ca/


Language The language of the conference is English. Speaker-Ready Room Please come to the speaker-ready room in the lower level of the Conference Centre (Soo Valley Room) the day before your session to download your presentation. If this is not possible, please do so as early as possible on the day of your presentation. You must have a PC-compatible presentation. The room will be open from 9:00 am-11:00 am and 2:00-4:00 pm each day, starting Wednesday, September 11, 2013. Wireless Internet Wifi Internet access is available free of charge throughout the hotels and Conference Centre. Certificate of Attendance A signed certificate is provided in the delegate backpack. Sightseeing/tourist activities There is every nature of activity available at Whistler. Please see our website at http://www.ifpa2013.ca/travel/whistler/ for descriptions of events and to book. Information is also available at your hotel.

http://www.ifpa2013.ca/travel/whistler/


Business Meeting Schedule for IFPA 2013 Meeting

Tuesday September 10, 2013

4:30pm – 6:30pm Crystal Lodge & Suites – Crystal Lodge Boardroom IFPA Executive Meeting (by invitation) 6:30pm – 9:30pm Ric’s Grill in Crystal Lodge & Suites Lobby IFPA Executive Dinner (by invitation)

Wednesday September 11, 2013

9:00am – 12:00pm Whistler Conference Centre – Wedgemount A/B

IFPA Executive Meeting (by invitation)

Thursday September 12, 2013

7:30am – 8:30am Whistler Conference Centre – Wedgemount A/B

IFPA Awards Committee (by invitation)

5:45pm – 6:15pm Whistler Conference Centre Sea to Sky Ballroom A

IFPA Business Meeting (all delegates)

Friday September 13, 2013

7:30am – 8:30am Whistler Conference Centre – Wedgemount A/B

Placenta Editorial Board Meeting (by invitation)

6:00pm – 6:30pm Whistler Conference Centre – see below

Regional Business Meetings (by invitation)

PAA Regional Business Meeting Garibaldi A

EPG Regional Business Meeting Garibaldi B

ANZPRA Regional Business Meeting Fitzsimmons


Saturday September 14, 2013

7:30am – 8:30am Whistler Conference Centre – Wedgemount A

Awards Committee Meeting (by invitation)

1:00pm – 2:30pm Whistler Conference Centre - Garibaldi A

Final Poster Judging Awards Committee


Social Program Schedule for IFPA 2013 Meeting


7:30pm – 9:30pm Whistler Conference Centre - Grand Foyer

Opening Reception (YW LOKE and NIH Awards)

Thursday September 12, 2013

7:30pm – 9:30pm 21 Steps Kitchen/Bar - St. Andrew's House Main Village

Early Career Researcher Social

8:00pm Village Location TBA

Amazing IFPA Race

Friday September 13, 2013

7:30pm – 11:00 pm Squamish Lil’wat Cultural Centre

Dinner and Performance (9 pm) at the Squamish Lil’wat Cultural Centre

Saturday September 14, 2013

7:30pm – 8:00pm Whistler Conference Centre - Grand Foyer

Pre GALA Dinner Reception

8:00pm – 1:00am Whistler Conference Centre - Sea to Sky Ballroom

GALA Dinner and Dance (Awards)


Full Program

Tuesday September 10, 2013

Registration 2:00pm – 4:00pm Crystal Lodge Suites

IFPA Executive Meeting (Invitation only) 4:30pm – 6:30pm Crystal Lodge Boardroom

IFPA Executive Dinner (Invitation only) 6:30pm – 9:30pm Ric’s Grill - Steak Seafood and Chop House, Crystal Lodge Suites


IFPA Executive Meeting (Invitation only) 9:00am – 12:00pm Wedgemount A/B

Registration 10:00am – 12:00pm Whistler Conference Centre - Grand Foyer 1:00pm – 3:00pm Whistler Conference Centre - Grand Foyer

Welcome - IFPA Meeting 2013 Opening 4:00pm – 4:30pm Whistler Conference Centre Sea to Sky Ballroom A Chairs: IFPA Meeting 2013 Conference Chair: Isabella Caniggia MD, PhD Division Head University of Toronto Department of Obstetrics and Gynaecology: John Kingdom MD President of IFPA: Nick Illsley DPhil

Plenary 1 4:30pm – 6:30pm Whistler Conference Centre Sea to Sky Ballroom A Oxygen and Stem Cells: of Mice and Women Chairs: Stacy Zamudio PhD (USA) and Jay Cross DVM, PhD (Canada)

PL1.1 4:30pm-5:10 pm (35 min + 5 min for questions) Keynote Speaker “Oxygen availability and stem cell homeostasis” M Celeste Simon PhD, University of Pennsylvania School of Medicine, Philadelphia, USA PL1.2 5:10 pm-5:50 pm (35 + 5 min for questions) “Programming and reprogramming to the trophoblast lineage” Myriam Hemberger PhD, University of Cambridge, Cambridge, United Kingdom PL1.3 5:50 pm-6:30 pm (35 + 5 min for questions) “Transposon-mediated reprogramming provides a powerful tool for understanding stem cell induction” Andras Nagy PhD, University of Toronto, Toronto, Canada


Welcome Reception 7:30pm - 8:00pm Whistler Conference Centre Grand Foyer Welcome cocktails and reception 8:00pm – 9:30pm Whistler Conference Centre Grand Foyer Appetizers and Dinner Welcome from the Mayor of Whistler: Her Worship Nancy Wilhelm-Morden LLB Award presentation: National Institutes of Health New Investigator Travel Awards (presented by Les Myatt PhD and Isabella Caniggia MD PhD) The Y.W. Loke New Investigator Travel Awards (presented by Graham Burton MD, DSc, FMedSci and Isabella Caniggia MD PhD)

Thursday September 12, 2013 Final Registration 7:00am – 8:30am Whistler Conference Centre Grand Foyer

Breakfast 7:00am – 8:30am Whistler Conference Centre Sea to Sky Ballroom C

Awards Committee 7:30am – 8:30am Whistler Conference Centre Wedgemount A/B

Plenary 2 8:30am – 10:30am Whistler Conference Centre Sea to Sky Ballroom A Hot Topics in Vascular Biology Chairs: Anne Croy DVM, PhD (Canada), Ori Nevo MD (Canada) PL2.1 8:30am-9:10am (35+5 min) "The enigmatic role of endoglin in placenta" Sponsored by Miraculins Inc. Keynote Speaker Michelle Letarte PhD, University of Toronto, Canada PL2.2 9:10am-9:50am (35+5 min) “The fetal endothelium of the human placenta: Advantages and perils of phenotypic plasticity” Lopa Leach PhD, University of Nottingham, United Kingdom PL2.3 9:50am-10:30am (35+5 min) "Novel insights into the regulation of uterine vascular tone by sphingosine 1-phosphate" Denise Hemmings PhD, University of Alberta, Edmonton, Canada

Coffee Break 10:30am – 11:00am Whistler Conference Centre Sea to Sky Ballroom C


New Investigator Oral Session 1 11:00am – 12:15pm Whistler Conference Centre Sea to Sky Ballroom A Thursday, September 12, 2013 Sponsored by Women and Children’s Health Research Institute, University of Alberta Chairs: Charles Graham PhD (Canada) and Larry Chamley PhD (NZ) Each speaker has 10 minutes + 5 min for questions. 1. NI.12 11:00am – 11:15am “The NAD-dependent deacetylase Sirtuin-1 regulates trophoblast differentiation and placental development” Kanaga Arul Nambi Rajan, University of California San Diego, La Jolla, California, USA 2. NI.6 11:15am – 11:30am “Transforming Growth Factor Beta 3 (TGFβ3): A Novel Regulator of Ceramide Metabolism in the Human Placenta” Sarah Chauvin, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada 3. NI.13 11:30am – 11:45am “Macrophage-derived interleukin-33 is a critical factor for placental growth” Valerie Fock, Medical University of Vienna, Vienna, Austria 4. NI.5 11:45am – 12:00pm “Replication Timing Predicts Underreplicated Domains in Polyploid Trophoblast Giant Cells” Roberta Hannibal, Stanford University School of Medicine, Stanford, CA, USA 5. NI.7 12:00pm – 12:15pm “Maternal uterine secreted mediator, VEGF, enhances embryo development and implantation” Natalie Hannan, Dept. Zoology, University of Melbourne, Parkville, Victoria, Australia

Lunch 12:15pm – 1:00pm Whistler Conference Centre Sea to Sky Ballroom C


Workshop Session 1 (See Appendix A for full description) 1:00pm – 3:00pm Whistler Conference Centre:

Sea to Sky Ballroom A

Garibaldi A

Garibaldi B

Fitzsimmons Rooms will be allocated according to numbers. Please sign up for your choices at the registration desk. Thursday, September 12, 2013 1:00pm – 3:00pm Workshop 1.1: Diabetes in pregnancy: New insight into signalling pathways and regulators Organizers: Lopa Leach (Nottingham, UK) and Gernot Desoye (Graz, Austria) Workshop 1.2: Use of “omics” in understanding placental development and pathologies Sponsored by the Hospital for Sick Children Organizers: Greg Rice (Brisbane, Australia) and Martin Post (Toronto, Canada) Workshop 1.3: Dual ex vivo perfusion of an isolated cotyledon of human placenta Organizers: Paul Brownbill (Manchester, UK), Stefan Hansson (Lund, Sweden), Henning Schneider (Bern, Switzerland) Workshop 1.4: Maternal placental immunological interactions: Advances in the field Organizers: Caroline Dunk (Toronto, Canada) and Michelle Letarte (Toronto, Canada)

Poster Session 1 and Coffee Break 3:00pm – 5:00pm P1.1-P1.133 Posters: Whistler Conference Centre Grand Foyer (including Mountain View) and Sea to Sky Ballroom B Coffee: Whistler Conference Centre Sea to Sky Ballroom C

See Appendix C for poster listings New Investigator Poster Presenters will present for 3 minutes and answer questions for 3-5 minutes for judges.

Note: Please remove your poster after your session. We will remove it if this does not occur and

cannot guarantee its condition.

IFPA Placentology Award 5:00pm – 5:45pm Whistler Conference Sea to Sky - Ballroom A Chairs: Thomas Jansson MD, PhD (USA), Vicki Clifton PhD (Australia) “Preeclampsia, the decidual battleground and future maternal cardiovascular disease” Annetine Staff MD, PhD, Oslo University Hospital, Women and Children's Division, Deptartment of Obstetrics and Deptartment of Gynecology, Faculty of Medicine, University of Oslo, Norway

IFPA Business Meeting 5:45pm – 6:15pm Whistler Conference Centre - Sea to Sky Ballroom A

Dinner on your own 6:15pm – 7:30pm Feel free to explore Whistler’s culinary delights, right outside the Conference

Centre doors.


ECR Social 7:30pm – 9:30pm 21 Steps Kitchen/Bar - 4433 Sundial Place

The Amazing IFPA Race 8:00 – 9:30pm A roving good time based in Whistler Village and including trivia, scavenging and guessing. Join us for an IFPA first, and we hope, annual event, which concludes with the winners hailed at the Olympic Rings!

Friday September 13, 2013 Breakfast 7:00am – 8:30am Whistler Conference Centre - Sea to Sky Ballroom C

Placenta Editorial Board Meeting 7:30am – 8:30am Whistler Conference Centre – Wedgemount A/B

Workshop Session 2 (See Appendix A for full description)

8:30am -10:30am Whistler Conference Centre:


Garibaldi A

Garibaldi B

Fitzsimmons Rooms will be allocated according to numbers. Please sign up for your choice at the registration desk. Workshop 2.1: Planning and coordination of a Placenta Research Network Chairs: Sally Collins (Oxford, UK) and Stacy Zamudio (Hackensack, USA) Workshop 2.2: Novel determinants of trophoblast cell fate Chairs: Andrea Jurisicova (Toronto, Canada) and Sascha Drewlo (Detroit, USA) Workshop 2.3: Maternal dyslipidemia in pregnancy: Effects on placental function and fetal growth Chairs: Theresa Powell (San Antonio, USA) and Vicki Clifton (Adelaide, Australia) Workshop 2.4: Oxygen in placental development and pathologies Organizers: Alessandro Rolfo (Turin, Italy) and Charles Graham (Kingston, Canada)

Trophoblast Research Award 10:30am – 11:00am Whistler Conference Centre Sea to Sky Ballroom A Chairs: Graham Burton MD, DSc, FMedSci (UK) and Sally Collins PhD (UK)(To be confirmed) TRA: “Pregnancy-related miRNAs in trophoblastic cells” Diana Maria Morales-Prieto, Placenta-Lab, University Hospital Jena, Jena, Germany


New Investigator Oral Session 2 11:00am – 12:00pm Whistler Conference Centre Sea to Sky Ballroom A Friday, September 13, 2013 Sponsored by Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research Chairs: Anthony Carter PhD (Denmark) and Theresa Powell PhD (US) Each speaker has 10 minutes + 5 min for questions. 1. NI.9 11:00am – 11:15am “p18 Contributes to Aberrant Cyclin-D1 Expression in Preeclamptic Placental Mesenchymal Stromal Cells (PDMSCs)” Anna Maria Nuzzo, Deptartment of Surgical Sciences, University of Turin, Turin, Italy 2. NI.11 11:15am – 11:30am “Decidual mesenchymal stem cells have reduced resistance to oxidative stress in preeclampsia, which is restored by the aldehyde dehydrogenase agonist Alda-1” Gina Kusuma, University of Melbourne Department of Obstetrics and Gynaecology and Department of Perinatal Medicine Pregnancy Research Centre, Royal Women's Hospital, Australia 3. NI.10 11:30am – 11:45am “Mass Spectrometry Imaging of Sphingolipids in Preeclamptic Placentae” Leonardo Ermini, Hospital for Sick Children Research Institute, Toronto, Canada 4. NI.1 11:45am – 12:00pm “The yolk sac of Necromys lasiurus (Rodentia, Cricetidae) as a promising source of mesenchymal stem cells” Phelipe Favaron, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

Lunch and ECR Session 12:00pm – 1:00pm Whistler Conference Centre Sea to Sky Ballroom A (ECR Session) Boxed Lunch Pickup - Whistler Conference Centre Sea to Sky Ballroom C "How to build a career in placental research" ECR Session Nick Illsley (New Jersey) and John Kingdom (Toronto) (To be confirmed)

Plenary 3 1:00pm – 3:00pm Whistler Conference Centre Sea to Sky Ballroom A Hello: Placenta meets Mother – the Maternal-Fetal Interface Chairs: Danièle Evain-Brion MD, PhD (France) and Tullia Todros MD (Italy) PL3.1 1:00pm – 1:40pm (35 minutes plus 5 minutes for questions) "Development and function of trophoblast cells regulating maternal metabolic adaptations to pregnancy" Keynote Speaker Jay Cross DVM, PhD, University of Calgary, Calgary, Alberta, Canada


PL3.2 1:40pm – 2:20pm (35 + 5 minutes) “Reversing the roles? May trophoblast protect the decidua? A putative role for the macrophage migratory inhibitory factor” Estela Bevilacqua PhD, University of São Paulo, São Paulo, Brazil PL3.3 2:20pm – 3:00pm (35 + 5 minutes) "Where is the maternofetal interface?" Larry Chamley PhD, The University of Auckland, Auckland, New Zealand

Poster Session 2 and Coffee Break 3:00pm – 5:00pm P2.1-P2.132 Whistler Conference Centre – Grand Foyer, Mountain View & Sea to Sky Ballroom B Sea to Sky Ballroom C – Coffee

See Appendix D for poster listings New Investigator Poster Presenters will present for 3 minutes and answer questions for 3-5 minutes for judges.

Note: Please remove your poster after your session. We will remove it if this does not occur and

cannot guarantee its condition.

NI Organized Debate Session 5:00pm – 6:00pm Whistler Conference Centre Sea to Sky Ballroom A "Of Mice and Women; Can animal models reliably predict the behaviour of the human placenta?" S Lee Adamson PhD (Canada) (mice) debating Les Myatt PhD (USA) (women) Moderator: Yoel Sadovsky MD (USA)

Dinner and Performance 7:30pm – 10:30pm Squamish Lil’wat Cultural Centre 7:30pm – 10:30pm Dinner 9:00pm – 9:30pm Eagle Song Dancers - A traditional dance group from Squamish Lil’wat Nation.

Saturday September 14, 2013 Breakfast 7:00am – 8:30am Whistler Conference Centre Sea to Sky Ballroom C Awards Committee Meeting 7:30am – 8:30am Whistler Conference Centre Wedgemount A/B

Plenary 4 8:30am – 10:30am Whistler Conference Centre Sea to Sky Ballroom A Bits and Pieces: Fetal DNA, TrophomiRs and 100 Years Chairs: Stephen Lye PhD (Canada) and Les Myatt PhD(USA)


PL4.1 8:30am-9:10am (35 minutes +5 minutes for questions) National Institutes of Health Lecture “Cell-free DNA in maternal plasma as a reflection of placental health and disease” Diana Bianchi PhD, Tufts University School of Medicine, Boston, MA, USA PL4.2 9:10am-9:50am (35 +5 minutes) “1000 days vs. 100 years: Complexities of Programming Relevant to Placentology” Kent Thornburg PhD, Oregon Health and Science University, Oregon, USA PL4.3 9:50am-10:30am (35 +5 minutes) "TrophomiRs and placental adaptation to injury" Yoel Sadovsky MD, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Coffee Break 10:30am – 11:00am Whistler Conference Centre Sea to Sky Ballroom C

New Investigator Oral Session 3

11:00am – 12:00pm Whistler Conference Centre Sea to Sky Ballroom A Saturday, September 14, 2013 Chairs: Andrée Gruslin MD, FRCSC (Canada) and Annetine Staff MD PhD (Norway) Each speaker has 10 minutes + 5 min for questions. 1. NI.4 11:00am – 11:15am 10 minutes + 5 min for questions) “Gene Expression Differences Reveal Ancestry-Specific Environmental Interactions in Placental Adaption to High-Altitude Hypoxia” William E. Gundling, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA 2. NI.8 11:15am – 11:30am “Docosahexaenoic Acid (DHA) Supplementation Decreases Inflammatory Signaling in Placenta from Obese Women” Susanne Lager, Department of OB/GYN, University of Texas Health Science Center, San Antonio, Texas, USA 3. NI.3 11:30am – 11:45am “Identification of candidate genes in human placenta involved in the development of childhood allergy” Astrud Tuck, University of Adelaide, Adelaide, South Australia, Australia 4. NI.2 11:45am – 12:00pm “Intra Placental Gene Transfer of Ad-hIGF-1 in a Mouse Model of Placental Insufficiency (PI) Corrects Liver Growth Factor Expression ( IGFBP-1)” Khaled Omar, Cincinnati Childrens Hospital Medical Centre, Cincinnati, Ohio, USA


Lunch 12:00pm – 1:00pm No lunch provided Feel free to explore Whistler’s many and varied places in the Village to eat and drink.

Final Poster Judging 12:00pm – 1:00pm Mountain View area of the Grand Foyer

Note: The 10 finalists will be asked to mount their posters in the Mountain View area of the Grand Foyer. Winners will be announced at the Gala Dinner.

Plenary 5 1:00pm – 3:00pm Whistler Conference Centre Sea to Sky Ballroom A Mid-Career Highlights Chairs: Stefan Hansson MD, PhD (Sweden) and S. Lee Adamson PhD (Canada) PL5.1 1:00pm-1:30pm (25 minutes + 5 minutes for questions) “Maternal and placental antioxidant response to preeclampsia: impact on vasoactive eicosanoids” Jean François Bilodeau, PhD, Université Laval, Québec City, Québec, Canada PL5.2 1:30pm-2:00pm (25 minutes + 5 minutes for questions) “ADAM-12: a novel trophoblast invasion-related metalloproteinase” Jürgen Pollheimer, PhD, Medical University of Vienna, Vienna, Austria PL5.3 2:00pm-2:30 pm (25 + 5 minutes) “Placental transcription factors and their role in regulating human fetal growth” Padma Murthi, PhD, Royal Women’s Hospital, Australia

PL5.4 2:30pm-3:00 pm (25 + 5 minutes) “Omics exploration of placental pathologies and development: tissues, cells and genes” Brian Cox, PhD, University of Toronto, Toronto, Ontario, Canada

Workshop Session 3 (See Appendix A for full description) Saturday, September 14, 2013 3:00-5:00pm Whistler Conference Centre:


Garibaldi A

Garibaldi B

Fitzsimmons Rooms will be allocated according to numbers. Please sign up for your choice at the registration desk. Saturday, September 14, 2013 3:00-5:00pm Workshop 3.1: Placental imaging: Insights into current and future modalities Organizers: Andrée Gruslin (Ottawa, Canada) and Tullia Todros (Turin, Italy) Workshop 3.2: Stem cells: From biology to pathology Sponsored by Insception Biosciences Organizers: Bill Kalionis (Melbourne, Australia) and Mohamed Abumaree (Riyadh, Saudi Arabia) Workshop 3.3: Bioinformatics tools for gene expression analysis Organizers: Douglas Kniss (Columbus, Ohio) and Brian Cox (Toronto, Canada)


Workshop 3.4: Evolutionary approaches to understanding preeclampsia: the view from the placenta Organizers: Derek Wildman (Detroit, USA) and Anthony Carter (Odense, Denmark)

IFPA Senior Award 5:00pm – 5:45pm Whistler Conference Centre Sea to Sky Ballroom A Chairs: John Kingdom MD (Canada) and Nick Illsley DPhil (USA) “Making Sense of Preeclampsia” Christopher Redman MD (UK), Oxford University Nuffield Department of Obstetrics

GALA Dinner 7:30pm – 1:00am Whistler Conference Centre Grand Foyer and Ballrooms B and C 7:30pm – 8:00pm Reception Whistler Conference Centre Grand Foyer 8:00pm – 1:00am Dinner and Dancing Whistler Conference Centre Ballrooms B and C

Award presentation Elsevier Placenta New Investigator Award (Oral) (Presented by Martin Knöfler/Estela Bevilacqua and Joan Anuels) Elsevier Trophoblast Research New Investigator Award (Poster) (Presented by Theresa Powell and Joan Anuels) IFPA Award in Placentology (Presented by Estela Bevilacqua and Nick Illsley) IFPA Senior Award in Placentology (Presented by Estela Bevilacqua and Nick Illsley)


Invited Speaker Biographies

Diana W. Bianchi

Diana W. Bianchi is the Executive Director of the Mother Infant Research Institute at Tufts Medical Center and the Natalie V. Zucker Professor of Pediatrics, Obstetrics and Gynecology at Tufts University School of Medicine. She is also Vice Chair for Pediatric Research at the Floating Hospital for Children, Boston. Dr. Bianchi received her M.D. from Stanford University School of Medicine. She received her residency training in Pediatrics at the Children’s Hospital, Boston and her postdoctoral fellowship training in both Medical Genetics and Neonatal-Perinatal Medicine at Harvard. She is board-certified in all three specialties and is a practicing medical geneticist with special expertise in reproductive genetics. Dr. Bianchi’s translational research focuses on prenatal genomics

with the goal of advancing noninvasive prenatal DNA diagnosis and using the fetal transcriptome to develop new fetal therapies. Dr. Bianchi has published over 240 peer-reviewed articles, and is one of 4 authors of the book Fetology: Diagnosis and Management of the Fetal Patient. This book won the Association of American Publishers award for best textbook in clinical medicine in 2000. The second edition was published in April 2010 and is already in its third printing. It has been translated into Japanese, Mandarin, and Spanish. Dr. Bianchi is recognized locally, nationally and internationally for her leadership roles. She is Editor-in-Chief of the international journal Prenatal Diagnosis. She is a member of the National Advisory Council of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and is a Past President of the International Society for Prenatal Diagnosis and the Perinatal Research Society. Dr. Bianchi has received multiple awards, including the Duane Alexander Award for leadership and mentorship in perinatal medicine from NICHD, and the Christopher Columbus Spirit of Discovery Award from Tufts University.

Jean-François Bilodeau

Dr. Jean-François Bilodeau is a full professor in the department of

Obstetrics, Gynecology, and reproduction at Laval University. After a Ph.D.

in Cellular and molecular biology (Laval University) obtained in 1998, he

pursued at the postdoctoral level on the role of oxidative stress in fertility

at the Royal Victoria Hospital (McGill University). Dr. Bilodeau obtained a

position at Laval University in 2004. He is interested in the role of oxidative

stress in the pathophysiology of preeclampsia. The main focus of his work is

antioxidant selenoproteins and their effects on the synthesis of

conventional and unconventional eicosanoids, known vasoactive agents.

With the help of a grant from the Canada Foundation for Innovation, Dr.

Bilodeau has developed a platform of mass spectrometry for the analysis of eicosanoïds like isoprostanes

generated by oxidative stress. Dr. Bilodeau has been recipient of the Canadian Institutes of Health Research

(CIHR), Institute of Aging, New Investigators award, and more recently of a Research Scholar Award from

Fonds de Recherche du Québec en Santé (FRQS). He is also involved at local and national levels in peer review

committees for the CIHR and other granting agencies.


Larry Chamley

Larry Chamley completed his PhD in 1993 at The University of Auckland, New Zealand, studying the mechanisms by which antiphospholipid antibodies led to still birth and recurrent miscarriage. Funded by an Overseas Research Fellowship of the NZ Health Research Council he then moved to study the role of complement control proteins in pregnancy complications with Peter Johnson at the University of Liverpool (UK). He returned to New Zealand in 1996 to establish his own research group. Larry is now is an Associate Professor in the

Department of Obstetrics and Gynaecology, The University of Auckland, New Zealand, where he heads a research group studying the biology and immunology of reproduction. He is also the Director of the BSc and BSc(Hons) in Biomedical Sciences at The University of Auckland. Larry is a member Executive Councils of the Australia and New Zealand Placental Research Association, the Society for Reproductive Biology (Australia), and the International Federation of Placenta Associations. He is a member of the editorial boards of the journals, Trophoblast Research/Placenta and the Journal of Reproductive Immunology. Larry has a particular interest in the interactions between trophoblast debris, that is shed from the syncytiotrophoblast into the maternal blood, and the maternal vascular and immune systems and how these interactions may lead to maternal immune tolerance of the fetus or pregnancy disorders. His group have shown that in normal pregnancy trophoblast debris is produced by an apoptosis-like process. They have also shown that factors that are present in preeclamptic blood, such as antiphospholipid antibodies or IL-6, switch the mechanism of cell death in the syncytiotrophoblast to a more necrotic process and also increase the amount of debris shed from the syncytiotrophoblast. This may have important consequences for pregnant women, as they have shown that endothelial cells phagocytose both apoptotic and necrotic trophoblast debris. While necrotic debris induced endothelial cell activation, apoptotic debris induced a “tolerant state” in which the endothelial cells were refractory to activation by a range of potent activators. They have also shown that phagocytosis of apoptotic trophoblast debris induces a tolerogenic/immunosuppressive phenotype in macrophages. Shedding and clearance of apoptotic trophoblast debris may therefore be an important mechanism for preventing maternal immune rejection of the fetus and may aid in the normal maternal vascular adaptation to pregnancy.


Jay Cross Dr. Cross is currently on sabbatical leave as Professor of Comparative Biology & Experimental Medicine, Biochemistry & Molecular Biology, Medical Genetics, and Obstetrics & Gynaecology at the University of Calgary. He took undergraduate studies at McGill University, and received a Doctorate of Veterinary Medicine (DVM) from the University of Saskatchewan in 1987, before completing his PhD at the University of Missouri in 1991, and doing postdoctoral work at the University of California in San Francisco. In 1994, he joined the faculty at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital

and the Departments of Molecular & Medical Genetics, and Obstetrics & Gynaecology at the University of Toronto, and then moved to the University of Calgary in 2000. At the University of Calgary, Dr. Cross was the founding Director of the Institute of Maternal & Child Health a multi-disciplinary institute focused on biomedical, clinical and social aspects of child health and development. He also founded the Training Program in Genetics, Child Development & Health, and the Clara Christie Centre for Genomics and Modeling of Human Disease. He was the founding Associate Dean-Research and Graduate Education of the Faculty of Veterinary Medicine, and most recently served as Associate Vice President Research of the university. Dr. Cross has published over 120 primary research articles and book chapters and is an internationally recognized expert in the areas of stem cell biology, animal reproduction, embryology, and molecular genetics particularly in the areas of embryo implantation and placental development and function. He is a Fellow of the Canadian Academy of Health Sciences, and a former Scholar and Investigator of the Canadian Institutes of Health Research (CIHR) and Scientist of the Alberta Heritage Foundation for Medical Research (AHFMR). Notable major awards include a Premier’s Research Excellence Award (PREA) of Ontario in 1999, Research Scientist of the Year Award from the Association of Professors of Obstetrics & Gynecology in 2005, and Pioneer Award from the Frontiers in Reproduction Program at the Marine Biology Laboratory, Wood’s Hole in 2009. Dr. Cross has served on numerous committees for the CIHR, the Heart & Stroke Foundation, the National Cancer Institute of Canada, the National Institutes of Health in the U.S., Gairdner Foundation, and is a frequent invited speaker in Canada, the U.S., Europe and Asia.


Myriam Hemberger

Myriam Hemberger trained at the University of Freiburg and Max-Planck Institute for Molecular Genetics, Berlin, Germany, (PhD) and as postdoctoral fellow in Dr. Jay Cross’ lab at the Samuel Lunenfeld Research Institute in Toronto and at the University of Calgary, Canada. Since 2004 she has been group leader at the Babraham Institute in Cambridge, UK, first as MRC Career Development Fellow and since 2009 on a tenured position as part of Babraham’s Epigenetics Programme. Her research interests are on molecular mechanisms of the genetic – epigenetic crosstalk that ensures formation of a functional placenta. In 2007 she was awarded the IFPA Award in Placentology for her

contributions to the field. Recent work has focussed on epigenetic hallmarks that underpin the first cell lineage decisions in the early embryo and dictate the differentiative plasticity of derived stem cell populations, notably embryonic (ES) and trophoblast (TS) stem cells. Current project areas include (i) characterization of the epigenetic landscape of the trophoblast lineage that is required for further differentiation into the various trophoblast cell types; (ii) the intersection between transcriptional networks and the epigenome that ensure the stem cell state of TS cells; (iii) characterization of transcription factor expression and epigenetic features in putative stem/progenitor cells in the human placenta and (iv) effect of physiological and environmental influences on the trophoblast’s epigenome and consequent differentiation deficits.


Denise Hemmings Dr. Denise Hemmings is an Associate Professor in the Department of Obstetrics and Gynaecology at the University of Alberta (U of A). She received her PhD from the Department of Medical Microbiology and Immunology at the U of A in 2001 with Dr. Larry Guilbert where she investigated the mechanism by which human cytomegalovirus (HCMV) is transmitted from a pregnant woman to her foetus. She then continued as a postdoctoral fellow with Dr. Sandra Davidge in the Department of Obstetrics and Gynaecology where she studied vascular dysfunction in aging females and developmental origins of adult disease. Dr. Hemmings then used her unique combination of training in

virology, vascular biology, reproductive immunology and placentology to develop an independent research program to study the role of a bioactive lipid called sphingosine 1-phosphate (S1P) in pregnancy. Her work as a faculty member focuses on the function of S1P in: (1) maternal vascular adaptations; (2) changes in uterine cell populations involved in early placental development and (3) changes in the uterus that initiate parturition. These studies compare normal pregnancy with those complicated by intrauterine growth restriction and preeclampsia. She is also investigating how active cytomegalovirus infections impair beneficial S1P-mediated effects on vascular tone. Dr. Hemmings is currently funded by the Canadian Institutes of Health Research (CIHR), National Science and Engineering Research Council of Canada and the Women and Children’s Health Research Institute of Alberta. Dr. Hemmings serves on several student advisory committees and is a reviewer for many scientific journals and funding agencies. She has a passion for training students and since her appointment in 2005 has trained more than 50 students from the high school to post-doctoral fellow level. She is the Chair of Women in Scholarship, Engineering, Science and Technology (WISEST), an organization encouraging young women to enter, stay and advance in science, engineering and technology careers. She also encourages students and staff in the basic sciences to step outside of their comfortable scientific boundaries to forge interdisciplinary links with clinicians.


Lopa Leach

Lopa Leach, BSc (hon), PhD, FAS, is an Associate Professor of Anatomy &

Vascular Biology at the School of Biomedical Science, Faculty of Medicine,

University of Nottingham, UK. Dr Leach graduated in Biology from Goldsmiths’

College, University of London and then obtained her PhD at King’s College

London. She spent her postdoctoral years at Imperial College studying trans-

placental transport of IgG and characterising the physiology and phenotype of

the human placental microcirculation. She obtained a faculty position in the

Department of Human Anatomy and Cell Biology at the University of

Nottingham in 1995. Since then her research has focussed on the role of junctional adhesion molecules

in regulating human placental vascular permeability and angiogenesis, with special emphasis on

mechanisms behind and consequences of feto-placental vascular impairment in pregnancies

complicated by diabetes mellitus. She also has an interest in the outer retinal barrier, mathematical

modelling of placental blood flow, chorionic vascular tone and homing mechanisms of placental stem

cells. Her research has been funded by The Welcome Trust, MRC, AICR, Anatomical Society and industry.

Dr Leach is currently the Honorary Secretary of the British Microcirculation Society, a Councillor and

Fellow of the Anatomical Society and a member of the editorial board of Microcirculation.


Michelle Letarte

I obtained my PhD in Biochemistry from the University of Ottawa and did my post-doctoral studies in Oxford, in the Immunochemistry Unit with Professors Rodney Porter and Alan Williams. I am a Senior Scientist at the Hospital for Sick Children in Toronto and Professor of Immunology, Medical Biophysics, Pediatrics and Obstetrics/Gynecology, at the University of Toronto. I have been involved for many years with the Canadian Society of Immunology and currently chair the Education Committee for the International Union of Immunological Societies. My research is primarily focused on the role of endoglin (CD105) in the vascular and immune systems, and in placenta. We discovered endoglin in 1984 as an endothelial cell marker expressed on all blood vessels and

endocardium. We demonstrated that endoglin was also expressed at high levels in the syncytiotrophoblast and played a role in trophoblast differentiation. We established endoglin as a co-receptor for several ligands of the TGF-dependent manner. In 1994, we demonstrated that endoglin was the gene mutated in Hereditary Hemorrhagic Telangiectasia type 1 (HHT1), an autosomal dominant vascular disorder associated with arteriovenous malformations. A second gene, ACVRL1 (ALK1), is responsible for HHT2, and the prevalence of HHT is 1:5,000 people, worldwide. We focused our efforts on patient samples, determined haploinsufficiency as the underlying mechanism of disease, elucidated 130 mutations, and established a recognized diagnostic test for HHT. We generated Endoglin null mice; the embryos die at mid-gestation of heart and vascular defects, while the adult heterozygous mice develop signs of HHT. We also studied the Acvrl1 heterozygous mice. Both mouse models revealed an uncoupling of endothelial NO synthase (eNOS), and production of superoxide rather than NO. Our findings revealed that endoglin and ALK1 interact with eNOS, a process perturbed in HHT and leading to impaired vasomotor function. We demonstrated that Endoglin and Acvrl1 heterozygous mice develop pulmonary hypertension, associated with eNOS uncoupling and preventable by oral consumption of the anti-oxidant, Tempol. More recently, we have studied the angiogenic profile of these mice and the effect of anti-angiogenic therapy in preventing signs of disease. We are also looking at the aggravated response of the Endoglin heterozygous mice to gut inflammation, how the immune system is affected and how anti-VEGF treatment can reduce the progression to chronic disease. We contributed to the discovery of a circulating form of endoglin (sEng) associated with preeclampsia. We are trying to understand how sEng is generated and how it may lead to maternal hypertension. Which of the TGF- -mediated pathways are affected by sEng? Is there cross-talk with VEGF and its soluble receptor sFlt-1, also implicated in preeclampsia. The function of endoglin in placenta remains somewhat of an enigma and much future work is required to establish its role in normal and pathological.


Padma Murthi Padma Murthi completed her Master of Science (1986) and Master of Philosophy (1988) in Biochemistry from the University of Madras, India. In 1995, she obtained her PhD in the Department of Medicine, University of Melbourne at Royal Melbourne Hospital, Melbourne, Australia. Her thesis was focused on the regulation of matrix proteins (proteoglycans) in Diabetic nephropathy.

In 1996, Padma was employed as a NHMRC (National Health and Medical Research Council) Post-doctoral Research Officer for three years in the Department of Medicine, University of Melbourne at Austin and Repatriation Hospital, Melbourne, where she investigated the mechanisms involved in macrophage diversity during Malaria infection. In 2000, Padma was appointed as a NHMRC Research Fellow in the Department of Obstetrics and Gynaecology, University of Melbourne at Royal Women’s Hospital. In 2002, Padma received University of Melbourne Research Fellowship for 2 years to investigate the role of placental transcription factors in human idiopathic fetal growth restriction. In 2006, Padma received an Early Career Researcher award from the University of Melbourne to investigate the role of homeobox transcription factors in placental angiogenesis. Padma has established international collaborations with leading placental biologists and endocrinologists at the University of Paris, France and Medical University of Graz, Austria, to study the molecular mechanisms of human placental development. These international collaborations are evident from her recent publications. In 2008, Padma was awarded a 3 year New (Sole Chief Investigator) Investigator project grant support, from the NHMRC. She is a chief investigator on two NHMRC project grants (2011-2013 and 2013-2015) and a National Heart Foundation grant 2011-2012. Padma spent two years (2009-2010) on sabbatical as a Visiting Researcher in INSERM, University of Paris, France, working in the laboratory of Dr Daniele Evain-Brion, located at the Faculty of Pharmacy in Paris. In collaboration with Dr Evain-Brion, Padma investigated the role homeobox genes and their target genes in early placental development. She is currently leader of her research team investigating the role of vitamin D in the regulation early human placental development. Padma is an Associate Editor of the journal “Placenta” and the “International Journal of Reproductive Sciences”. Padma is an elected Secretary of the Australian and New Zealand Placental Research Associations (ANZPRA) and an Executive member of International Federation for Placental Associations (IFPA).


Andras Nagy

Dr. Nagy is currently a Senior Scientist at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Professor in the Department of Obstetrics & Gynaecology and Institute of Medical Science at the University of Toronto, and Investigator at the McEwen Centre for Regenerative Medicine. He also holds a Tier I Canada Research Chair in Stem Cells and Regeneration. His research focuses on several areas of interest, which include 1) Functional studies of genes belonging to families with known roles in blood vessel formation; 2) Development of sophisticated genetic manipulation tools in the mouse model; 3) Applying genetics to cancer

research; 4) Derivation, differentiation and genetic modification of both mouse and human Embryonic Stem cells; 5) Reprogramming of somatic cells to pluripotent stem cells using a novel method based on the piggyBac transposon system and understanding the key molecular players in the reprograming process.

Jürgen Pollheimer

Jürgen Pollheimer studied Natural Sciences at the University of Vienna with emphasis on nutritional sciences and biochemistry. He obtained his Msc (2002) at the University of Vienna and subsequently finished his PhD (2006) at the Medical University of Vienna under the mentorship of Professor Martin Knöfler. His doctoral thesis was on regulatory mechanisms governing extravillous trophoblast differentiation. From 2006 until 2009, he underwent a postdoctoral training at the University

of Oslo (Department of Pathology, Section for Endothelial Cells, Rikshospitalet-Radiumhospitalet Medical Centre) and received a Postdoc fellowship from the Norwegian Cancer Society on the project: High endothelial venule-like differentiation of endothelial cells - a vascular phenotype associated with poor cancer prognosis. In 2009, he re-joined the research group of Martin Knöfler as a Senior Postdoc. Since April 2012, Jürgen holds an Assistant Professor position at the Medical University of Vienna, Department of Obstetrics and Fetal-Maternal Medicine. His research group focuses on the principles of extravillous trophoblast differentiation by taking advantage of various primary human trophoblast model systems. Currently, Jürgen's research projects deal with the role of ADAM-12 during extravillous trophoblast invasion and the impact of the novel IL-1 family member interleukin-33 on placental function. His future plans are to unravel the role of ERBB receptors in various stages of EVT differentiation, including proliferation/cell cycle arrest and acquisition of an invasive phenotype. In addition, he is interested to further identify novel subtype-specific trophoblast genes.


Yoel Sadovsky Yoel Sadovsky received his MD degree from the Hebrew University-Hadassah Medical School in Jerusalem in 1986, followed by OBGYN residency at Washington University in St. Louis and maternal-fetal medicine and postdoctoral research fellowships at the University of California, San Francisco. He then returned to Washington University as a reproductive biologist and specialist in high-risk pregnancy, where he was appointed tenured professor of OBGYN, and Cell Biology and Physiology. Dr. Sadovsky served as director of the Maternal-Fetal Medicine Fellowship at Washington University between 1997-2007, and as Director, Division of Maternal-Fetal Medicine and Ultrasound from 1999-2007. In 2007, he assumed Directorship of Magee-Womens Research Institute (MWRI) at the University of Pittsburgh, and Vice Chair (Research),

Department of Obstetrics, Gynecology and Reproductive Sciences. MWRI is the hub for approximately 110 reproductive sciences researchers at the University of Pittsburgh, 70 of whom reside at the Institute’s 120,000 sq ft research building and in the adjacent Magee-Womens Hospital. Dr. Sadovsky’s research on feto-placental development and trophoblast function parallels his clinical expertise in maternal-fetal medicine. Using human placental cells as well as mouse models, he studies molecular pathways that govern placental development and adaptive response to stress. Primary areas of research include: (1) The role of microRNA in placental function, where the lab combines computationally identified sets of miRNA targets with transcriptomic analysis, as well as overexpression and silencing approaches, to define critical placental microRNA targets, (2) Placental uptake and processing of metabolic fuels, with studies that center on the uptake, storage, and trans-placental trafficking of fatty acids that are critical for feto-placental development, (3) Placental injury and adaptation, defining hypoxic trophoblast gene regulatory networks. Dr. Sadovsky’s laboratory is funded via several NIH grants, and his investigation has resulted in the publication of 110 peer-reviewed scientific articles and 20 book chapters and invited publications, and his selection for the Society for Gynecologic Investigation’s (SGI) President’s Achievement Award in 2004. Dr. Sadovsky has served on several National Institute of Child Health and Human Development (NICHD) study sections, chaired the NICHD Maternal-Fetal Biology Research Study Section in 2005-06, the NICHD Genomic and Proteomic Network for Preterm Birth Research steering committee, and is currently a member of the NICHD Advisory Council and the NICHD Division of Intramural Research Review Panel. He chairs the March of Dimes Prematurity Research Initiative Advisory Committee, is a member of the March of Dimes Scientific Advisory Council and a number of other academic advisory boards. He also serves as an Editor for the journal Placenta. Dr. Sadovsky has trained numerous students, residents, post-doctoral fellows and faculty. He is the Research Director of the Magee-Womens Basic and Translational Reproductive Health Training (WRHR, NIH K12) Program, and a PI of the University’s Building Interdisciplinary Research Careers in Women’s Health (BIRCWH, NIH K12) program.


M. Celeste Simon M. Celeste Simon, Ph.D. is the Scientific Director of the Abramson Family Cancer Research Institute at the Perelman School of Medicine at the University of Pennsylvania. She is also an Investigator of the Howard Hughes Medical Institute. She received her bachelor's degree from Miami University and completed a Ph.D. in biochemistry at Rockefeller University in 1985. She conducted postdoctoral research with Joseph Nevins at Rockefeller and then with Stuart Orkin at Harvard Medical School. She became an Assistant Professor of Medicine and Molecular Genetics and Cell Biology at the University of Chicago in 1992. In a National Competition, she was named an Assistant Investigator of the

Howard Hughes Medical Institute in 1994. In 1999, she moved to the University of Pennsylvania School of Medicine and was one of the founding laboratories of the newly formed Abramson Family Cancer Research Institute (AFCRI) there. She was promoted to Associate Professor in 1999, and full Professor in 2006. In 2007, she became the Scientific Director of the AFCRI. Dr. Simon's research is focused on how cells sense and respond to changes in the availability of molecular oxygen. This impacts normal development, physiology, and numerous diseases, such as the growth of solid tumors. The Simon Laboratory is studying how O2 sensing impacts tumor angiogenesis, metabolism, and metastasis, and overall disease progression. She is studying both animal models and cancer patients with the ultimate goal of developing novel strategies to treat tumors such as pancreatic cancer, soft tissue sarcoma, colorectal cancer, and lung adenocarcinoma. Dr. Simon currently directs a laboratory of 20 individuals, including graduate students, postdoctoral fellows, clinical fellows, and research technicians. The AFCRI employs 400 researchers working in roughly 30 independent laboratories. Dr. Simon has received numerous awards recognizing her research, such as the Stanley N. Cohen Award for Biomedical Research and the Elliot Osserman Award from the Israel Cancer Research Fund.


IFPA Meeting 2013 Abstracts not printed in PLACENTA

PL1.1 Oxygen availability and stem cell homeostasis M Celeste Simon The Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania School of Medicine, Pennsylvania, USA Low levels of oxygen (O2) occur naturally in developing embryos. Cells respond to their hypoxic microenvironment by stimulating several hypoxia-inducible factors (and other molecules that mediate O2 homeostasis), which then coordinate the development of the blood, vasculature, placenta, nervous system and other organs. Furthermore, embryonic stem and progenitor cells frequently occupy hypoxic 'niches' and low O2 regulates their differentiation. Recent work has revealed an important link between factors that are involved in regulating stem and progenitor cell behaviour and hypoxia-inducible factors, which provides a molecular framework for the hypoxic control of differentiation and cell fate. These findings have important implications for the development of therapies for tissue regeneration and disease. P1.133 Deregulation of miRNAs from nuclear reprogramming errors occurred during placentogenesis in cloned pregnancy Md Munir Hossain1,2, Dawit Tesfaye2, Karl Schellander2, Mechael Hoelker2 1Bangladesh Agricultural University, Mymensingh, Bangladesh, 2University of Bonn, Bonn, Germany Background and objectives: Impeding Nuclear Transfer (NT) efficiency is largely addressed by placental abnormalities due to genetic and epigenetic modifications. MiRNAs are shown to be as major regulator of such modifications. Present study has been conducted to identify the patterns of miRNAs expression contributing to the widely addressed placental abnormalities in SCNT along with genetic and epigenetic modifications in the IVP or NT placentas. Methods: Present study has been carried out through quantification of 377 miRNAs in the Day-50 placenta derived from AI, IVP and SCNT pregnancies and in the donor fibroblast cells along with their detailed characterization. Furthermore, cell specific expression of selected miRNAs in the expanded blastocysts by whole mount in situ hybridization and their expression in blastocysts, day-16 elongated embryos, day-50 placentas and day 225 placentas (AI, IVP and SCNT pregnancies) along with status of methylation and activities of miRNAs processing molecules were studied. The probable sources of deregulation of miRNAs along with abnormalities in trophoblast cells mediated by this deregulation in in-vitro model have also been studied. Results: Present study identifies the expression patterns miRNAs and the mechanism of regulation which discloses a massive deregulation of miRNAs by poor reprogramming as chromosomal cluster or families without sex linkage in the NT and in vitro derived (IVP) placentas. The major deregulation found to be exhibited at day 50 of pregnancies, which are less dependent on global DNA methylation, rather aberrant miRNA processing molecules were evidenced. Among them, AGO2 has been found to be one of the reasons for deregulation of miRNAs and responsible for multiple defects in trophoblast differentiation through miRNAs mediated mechanism. Conclusion: Aberrant miRNAs activities might associate to the genetic and epigenetic modifications in abnormal placentogenesis from NT or IVP pregnancies. Effect of advanced maternal age on pregnancy outcome in the rat


P1.134 Alison Care, Jude Morton, Sandra Davidge University of Alberta, Edmonton, Alberta, Canada Objectives: The age at which women deliver their first child has increased steadily, particularly in Western societies. Data from Statistics Canada show a steady increase in women giving birth in the 30-34 and 35+ age groups from 1987 to 2005. Childbirth at an advanced maternal age has a myriad of clinical ramifications, including increased risk of maternal and perinatal morbidity. However, little is known about the impact of aging on vascular adaptations to pregnancy that might compromise pregnancy outcome. We hypothesize that maternal cardiovascular adaptations to pregnancy will be impaired in rats of advanced maternal age. Methods and Results: Sprague Dawley rats aged 9 months (approximately equivalent to a 35 year old woman) were capable of carrying viable pregnancies to late gestation (88.9% aged vs. 83.3% young viable pregnancies), although litter size was reduced (young (mean±SEM) = 15.25±2.4 pups, aged = 3.4±1.3 pups, P<0.01). On gestational day (GD)20-21, there was a reduced fetal:placental weight ratio in aged dams (young = 9.2±1.8 vs. aged = 6.3±1.9, P<0.05), indicating reduced placental efficiency. Systolic blood pressure was measured using tail cuff plethysmography, and was significantly increased in late gestation (GD18-20) in aged rats compared to young rats (P<0.05). Despite the expected reduction in blood pressure in young dams between mid gestation (GD10-13, 134.1±7.4 mmHg) and late gestation (112.7±6.0 mmHg, P<0.05), this did not occur in aged dams (mid-gestation = 137.7±7.1 mmHg and late gestation = 131.4±5.8 mmHg). Cumulative concentration response curves to phenylephrine (PE) in uterine arteries showed a trend toward increased sensitivity to PE in aged arteries (EC50 young = 7.7±0.1 vs. aged = 7.3±0.1, P = 0.057). Conclusion: Aging dams demonstrated impaired vascular responses in late gestation. Future studies will investigate whether increased levels of inflammation and reduced remodelling capacity of arteries are possible mechanisms. P2.131 Deregulation of miRNAs from nuclear reprogramming errors occurred during placentogenesis in cloned pregnancy Md Munir Hossain1,2, Dawit Tesfaye2, Karl Schellander2, Mechael Hoelker2 1Bangladesh Agricultural University, Mymensingh, Bangladesh, 2University of Bonn, Bonn, Germany Background and objectives: Impeding Nuclear Transfer (NT) efficiency is largely addressed by placental abnormalities due to genetic and epigenetic modifications. MiRNAs are shown to be as major regulator of such modifications. Present study has been conducted to identify the patterns of miRNAs expression contributing to the widely addressed placental abnormalities in SCNT along with genetic and epigenetic modifications in the IVP or NT placentas. Methods: Present study has been carried out through quantification of 377 miRNAs in the Day-50 placenta derived from AI, IVP and SCNT pregnancies and in the donor fibroblast cells along with their detailed characterization. Furthermore, cell specific expression of selected miRNAs in the expanded blastocysts by whole mount in situ hybridization and their expression in blastocysts, day-16 elongated embryos, day-50 placentas and day 225 placentas (AI, IVP and SCNT pregnancies) along with status of methylation and activities of miRNAs processing molecules were studied. The probable sources of deregulation of miRNAs along with abnormalities in trophoblast cells mediated by this deregulation in in-vitro model have also been studied. Results: Present study identifies the expression patterns miRNAs and the mechanism of regulation which discloses a massive deregulation of miRNAs by poor reprogramming as chromosomal cluster or families without sex linkage in the NT and in vitro derived (IVP) placentas. The major deregulation found to be exhibited at day 50 of pregnancies, which are less dependent on global DNA methylation, rather aberrant


miRNA processing molecules were evidenced. Among them, AGO2 has been found to be one of the reasons for deregulation of miRNAs and responsible for multiple defects in trophoblast differentiation through miRNAs mediated mechanism. Conclusion: Aberrant miRNAs activities might associate to the genetic and epigenetic modifications in abnormal placentogenesis from NT or IVP pregnancies. P2. 132 Protein expression by proteomic analysis in pregnancy of placenta accreta Te Yao Hsu, Chih Chang Tsai, Chia Yo Ou, Tiao Hsien Hung Kaohsiung chang Gung Memorial Hospital, Kaohsiung, Taiwan Objectives: Placenta accreta is associated with 7% maternal mortality rate ,as well as intraoperative and postoperative morbility cause by massive blood transfusion,infection and adjacent organ damage.The pathogenetic mechanisms of placenta accreta are complicated and multifactorial.Decidual defect is still a major contributing factor in the formation of placenta accreta.The study about proteomic analysis of placenta accreta has not been reported. We try to find a useful potential markers for placenta accreta in prenatal diagnosis. The goal of this study was to identify proteins or peptides associated with placenta accreta by means of a proteomic technique. Methods: Human placental tissue from five placenta accreta pregnancies and five normal cases were included in this study. Fluorescence-based two-dimensional difference gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) were used for comparative proteomic analysis. Peptide matching and protein search were performed automatically using the MASCOT software (Matrix Sciences, London, UK). The identified proteins were further validated by western blotting. Results: A protein profile produced by 2D-DIGEin narrow (4–7L) IPG strips,signifficant differentially expressed spots between placenta accreta women and normal pregnant women. Spots with different expression levels were excised and nineteen proteins were identified by MALDI-TOF.Ten spots was expressed more in the placenta accreta subjects than in the control subjects.Nine spots was expressed less in the placenta accreta subjectes than in control subjects . We used these nineteen spots to refer to the Swiss-port database.The differential expression of two up-regulated protein cyclic AMP-dependent protein kinase (PKA),Heat shock 70 kDa protein 4(HSP74) and one down-regulated placental lactogen (PL) was further confirmed by Western Bolt analysis using the appropriate antibodies in both placenta accreta and normal pregnancies. Conclusions: These three proteins may be involved in the pathogenesis of placenta accreta. Further validation in prospective studies with a larger sample size is warranted.


Appendix A – Workshop Program

Workshop 1

Workshop 1.1: Diabetes in pregnancy: New insight into signalling pathways and regulators Date: Thursday, September 12, 2013 Time: 1:00pm – 3:00pm Organizers: Lopa Leach (UK) and Gernot Desoye (Austria)

More than 346 million people worldwide have diabetes and approximately half of these are women. In addition, gestational diabetes affects 15% of pregnant women. The risks of diabetes to the fetus and the high risk of developing early onset cardiovascular disease and diabetes are likely to add to the global health burden. Despite these statistics, effects of maternal diabetes on the placenta remain under-researched and under-funded. Understanding the pathophysiology of the placenta and fetal vascular system, specifically the impairment of the signalling pathways and regulators, is essential. This workshop will therefore ask colleagues presenting in this conference, either on diabetes or key mechanisms that help us understand the fundamental science behind placental functioning, to attend. Speakers chosen from submitted abstracts will be given 5 min to explain their science/novel findings. The ensuing discussions will help summarise key areas where further research should be done and where therapeutic advances can be made so there can be a global initiative to try to understand and limit the effects of diabetes in pregnancy. Format and Sequence:

Each speaker will have 5 minutes for presentation of a) Concept – hypothesis b) Main results c) Relevance for diabetes in pregnancy

Speakers:

1. Gernot Desoye: Overview of problems associated with diabetes in pregnancy 2. Melissa Westwood: Use of network biology to understand the effects of hyperglycemia on the

trophoblast: a model of the placenta in diabetes mellitus 3. Lopa Leach: Vascular and endothelial changes in diabetes 4. Hong wa Yung: Phosphorylation changes in survival- and stress-response signalling pathways in the

human placenta as an artefact of delayed tissue collection 5. Qi-tao Huang: Increased plasma and placental advanced oxidation protein products levels in gestational

diabetes mellitus with placental vascular complications 6. WEI LIU: Placental dysmaturity underlies the superimposed chronic hypoxic change in stillbirths from

diabetic mothers 7. Shannon Bainbridge: SIRT1: Identification of a novel placental stress-response protein that regulates

fetal growth? 8. Domenica Giuffrida: Characterization of DUFFY Decoy Receptor in Placentae from Pregnancies

Complicated by Gestational Diabetes 9. Summary: Lopa Leach & Gernot Desoye.


Workshop 1.2 - Use of “omics” in understanding placental development and pathologies Sponsored by the Hospital for Sick Children Date: Thursday, September 12, 2013 Time: 1:00pm – 3:00pm Organizers: Greg Rice (Brisbane) and Martin Post (Toronto) The workshop will focus on selected “omics” approaches and platforms of relevance to placentology, including, RNASeq, DNA methylation profiling, lipidomics and nanovesicles as an “omics” target. Topics and Speakers: DNA Methylation – The Placental Methylome Wendy Robinson Child & Family Research Institute Vancouver RNASeq Pamela Hoodless BC Cancer Agency Vancouver BC Canada Mass Spectrometry Imaging of Metabolites Leonardo Ermini The Hospital for Sick Children Toronto Exosomes – an “omics” target Carlos Salomon UQCCR, University of Queensland Brisbane, Australia


Workshop 1.3 : Dual ex vivo perfusion of an isolated cotyledon of human placenta Date: Thursday, September 12, 2013 Time: 1:00pm – 3:00pm Organizers: Paul Brownbill (Manchester), Stefan Hansson (Lund), Henning Schneider (Bern) The workshop will focus on dual perfusion of human placental tissue. This technique was originally designed to study the variety of mechanisms involved in transplacental transport of different compounds. Great progress has been made in this area and sophisticated mechanisms involving specific transporters localised in the microvillous and basal surfaces of trophoblast, as well as in the endothelial cells of the villous capillaries have been identified. However, over the years the spectrum of applications has widened considerably, including the role of trophoblast metabolism, use of the perfusion system as a physiological model for the generation of syncytiotrophoblast micro- and nanovesicles, exposure of the trophoblast and its response to infectious as well as toxic agents, the assessment of the villous vasculature and differences in hemodynamic responses of normal as well as pathological placentae. Participants have been selected to put together a program refllecting this diversity of applications giving attending investigators an overview and possibly new ideas of using this technique in their respective fields of research. As part of their presentation each speaker will be asked to prepare a slide on what unique features – expected and possibly unexpected – the perfusion technique brought up and how it complements other means of investigation in their studies. Workshop format will be teaching lectures with questions and discussion. Program

Welcome and introduction – H. Schneider,

Adhesion of malaria parasites in the ex vivo dual placental perfusion model – C. Pehrson1, L. Mathiesen2, P. Damm3, S. Hansson4, C. King5, H. Schneider6, T. G. Theander1, L. E. Knudsen2 & M. A. Nielsen1 1) Center of Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious diseases, Copenhagen University Hospital, Denmark, 2) Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; 3) Department of Obstetrics, The Juliane Marie Centre, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; 4) Division of Obstetrics and Gynecology, Department of Clinical Sciences, University of Lund, Sweden; 5) Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA; 6) Department of Obstetrics and Gynecology, Insel Spital – University of Bern, Switzerland.

Dual perfusion provides new insights into bidirectional lipid transport across the placenta – C. Wadsack, B. Hirschmugl, I. Sreckovic, S. Kopp, G. Desoye & U. Lang Department of Obstetrics and Gynecology, Medical University of Graz, Austria.

Isolation and fractionation of placental perfusion derived syncytiotrophoblast micro- and nanovesicles – D. Tannetta, R. Dragovic, C. Redman & I. Sargent University of Oxford, John Radcliffe Hospital, Oxford Ox3 9DU, UK.

Ex-vivo placental perfusion to assess vascular function in normal and FGR placentas – S. Jones, E. Johnstone, H. Bischof, M. Wareing, S. Greenwood, C. Sibley & P.Brownbill Maternal and Fetal Health Research Center, Institute of Human Development, University of Manchester, UK.

The circulating amino acid milieu and placental amino acid transfer – R. Lewis Faculty of Medicine, University of Southampton MP887, Institute for Developmental Sciences Southampton General Hospital, UK


Workshop 1.4: Maternal placental immunological interactions: Advances in the field Date: Thursday, September 12, 2013 Time: 1:00pm – 3:00pm Organizers: Caroline Dunk (Toronto) and Michelle Letarte (Toronto) We will discuss some of the latest findings and techniques that have contributed to our expanding knowledge

of the interactions between the maternal decidual leukocytes and the fetal trophoblast and their effects. The

purpose of this workshop is to promote discussion on questions arising from the work presented. Audience

participation is highly encouraged. We are looking forward to seeing you all in lovely Whistler.

Best wishes,

Caroline Dunk and Michelle Letarte.

1.00-1.05 Welcome: Michelle Letarte

1.05-1.15 Dynamic changes in decidual leukocyte populations across gestation: New players in uterine

vascular remodeling. Caroline Dunk. Lunenfeld-Tanenbaum Research Institute, Mount Sinai

Hospital, Toronto, Canada.

1.20-1.35 Heterogeneity in uterine NK cell activation pathways. Anne Croy, Department of Biomedical

and Molecular Sciences, Queen’s University, Kingston, Canada

Poster Talks: 8 min followed by 5 min discussion

1.40-1.48 Investigating decidual natural killer cells in pregnancies with poor spiral artery remodeling. Alison Wallace, St George’s Hospital, University of London, London, UK.

1.53-2.01 Trypanosoma cruzi induces cellular proliferation and differentiation in the trophoblast.

Christian Castillo, Institute for Biomedical Sciences, Faculty of Medicine, University of Chile,

Santiago, Chile.

2.06-2.14 Modulation of macrophage differentiation from inflammatory M1 to anti-inflammatory M2

macrophages by placental cells: possible implications in inflammatory diseases. Mohamed

Abumaree College of Medicine, King Saud Bin Abdulaziz University for Health Sciences and

King Abdullah International Medical Research Center, King Abdulaziz Medical City, National

Guard Health Affairs, Riyadh, Saudi Arabia.

2.19-2.27 Inflammation as a cause of placental dysfunction in high-risk pregnancies. Sylvie Girard,

Maternal and Fetal Health Research Centre, University of Manchester, Manchester, UK.

2.32-2.40 Anti-inflammatory effect of Low Molecular Weight Heparin (LMWH) is mediated by Placental

High Mobility Group Box 1 (HMGB1) Modulation: New Therapeutic Perspectives for

Preeclampsia. Cristian Zeniro, Dept. of Surgical Sciences, University of Turin, Turin, Italy.

2.45-3.00 General Discussion and concluding remarks from Chairs


Workshop 2

Workshop 2.1 - Planning and coordination of a Placenta Research Network

Date: Friday, September 13, 2013 Time: 8:30 am – 10:30 am Chairs: Stacy Zamudio Hackensack University Medical Center, NJ USA

Sally Collins Oxford University, UK Background: The crucial, likely causal role played by the placenta in many pregnancy pathologies is being increasingly recognized. Exploring the role of the placenta in these pathologies presents a number of challenges. One is the limited numbers of clinical cases available through individual institutions, a problem resolved through development of consortia. Frequently, however, these groupings are formed around specific pathologies, limiting the amount and type of data applicable to other pathologies. Another challenge is the type and standardization of data parameters and the differences in data-gathering and analytical platforms between institutions. To overcome these challenges we are proposing the development of a Placenta Research Network. We visualize participant institutions and clinicians/scientists working jointly to determine the role of the placenta in pregnancy pathologies and to use placental structural and functional analyses for diagnostic purposes, clinical management, and for generation of basic science questions of translational importance. Format: We hope to have a lively but directed discussion focusing on a number of related goals addressing the feasibility of a Placenta Research Network Goals: 1) Institutional requirements necessary for a Network site (e.g. participation by a perinatal pathologist) 2) Determination of the type and nature of the data parameters to be collected across the network 3) Identification of the platforms (hardware, software) used by participating investigators/institutions

and the extent to which automated data collection in the course of a given ultrasound can be transferred to a common database.

4) Identification and agreement upon a limited number of pregnancy pathologies/specific research questions to form the basis for generating preliminary data. The objective here is to generate a history of collaboration and publication that can then lead to goal 7.

5) Ethics approval, consent, tissue banking and materials transfer 6) Organization and communication. 7) Funding! Participants: A core of participants interested in discussing Network possibilities has already been formed and will be attending. This includes Stacy Zamudio (Hackensack/NJ), John Kingdom (Toronto), Sally Collins (Oxford), Mana Parast (UC San Diego), Tullia Todros (Turin), Stephen Tong (Adelaide), Chris Redman (Oxford), Terry Lao (Hong Kong), Yoel Sadovsky (Pittsburgh) and Nick Illsley (Hackensack/NJ). We hope to have a number of people also participating via Skype, including Louise Laurent (UC San Diego), Ed Johnstone & Alex Heazell (Manchester), Craig Pennell (Western Australia), Anna David (London). We welcome other interested participants.


Workshop 2.2: Novel determinants of trophoblast cell fate Date: Friday, September 13, 2013 Time: 8:30 am – 10:30 am Organizers: Andrea Jurisicova (Canada) and Sascha Drewlo (USA) In the last decade, substantial evidence indicates that a compromised in utero environment can dramatically influence fetal development and health, impacting both early and late postnatal life. Altered placental development resulting in placental insufficiencies are believed to be responsible for the majority of cases of fetal mortality in humans. In addition, growth-compromised babies resulting from intrauterine growth restriction (IUGR) following placental insufficiency are at increased risk for adverse, long-term outcomes such as hypertension, obesity and type II diabetes. Thus, it is crucial to gain an understanding of the basic cellular and molecular events responsible for proper placental development and the origins of cellular defects observed in placental insufficiency. This workshop will therefore ask participants of this conference who focus their work on studies of trophoblast cell determination, commitment to differentiation and renewal to share their most recent findings. Speakers chosen from submitted abstracts will be given 15 min to explain problems they study as well as outline outcomes of their most recent work. Format and Sequence: Each speaker will have 12 minutes for presentation and 5 minutes for discussion. The format we have chosen is "State of the Art or State of the Affairs". At the end we would also like to have a 15 minute summary discussion with participants to explore where the next big challenges are, with a few sentences from each speakers on what we should focus on with respect to diagnosis and treatment. Speakers: 1. Andrea Jurisicova: Are key determinants of trophoblast stem cell fate conserved? 2. Mana Parast - BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated

through a dNp63+ cytotrophoblast stem cell state 3. Sussanah Varmuza - Epigenetic programming of trophoblast lineage – Role of Sfmbt2 4. Dan Rapolee - Stress pathways in trophoblast determination and placental development 5. Graham Burton - ER stress and its impact on placental disease 6. Larry Chamley - Final stages of trophoblast life -shedding and deportation 7. Sascha Drewlo leads and all participants: Summary and discussion with Audience


Workshop 2.3: Maternal dyslipidemia in pregnancy: Effects on placental function and fetal growth Date: Friday, September 13, 2013 Time: 8:30 am – 10:30 am Organizers: Theresa Powell (San Antonio) and Vicki Clifton (Adelaide) Workshop Summary Maternal dyslipidemia in pregnancy: Effects on placental function and fetal growth Lipid metabolism is dramatically altered during pregnancy resulting in a significant rise in circulating lipids and many pregnancy complications are associated with dyslipidemia, including obesity and gestational diabetes. Alterations in fetal growth and/or body composition are more common in these pregnancy complications and evidence suggests that fetal adiposity rather than lean body mass is increased with accelerated fetal growth. Starting life with greater fat mass leads to life-long excess adiposity and contributes to the association of high birth weight and programming of metabolic syndrome. This workshop will focus on the overall question: How does maternal dyslipidemia in pregnancy alter placental function and fetal growth? The speakers include established and new investigators and the presentations will cover three key areas. There will be short presentations of experimental data followed by group discussion relating to lipids in pregnancy. The discussion will be moderated by Theresa Powell and Vicky Clifton. Maternal lipid derangements in pregnancy and the impact of obesity, diabetes and asthma. Does dyslipidemia impact placental function and fetal growth? Alterations in cholesterol levels and placental cholesterol transfer in pregnancy complications including pre-eclampsia, gestational diabetes and IUGR will be presented. Lipids as signaling molecules will provide insight into the role of bioactive lipids, sphingolipids and ceramides, as intracellular signaling molecules, that alter syncytiotrophoblast function and growth in pre-eclampsia, IUGR and high maternal BMI. Lipid transport in pregnancies complicated by obesity will focus on sex differences in placental lipid transporters in response to maternal obesity and the localization of the FATPs in human syncytiotrophoblast plasma membranes and changes in their expression related to maternal obesity. These presentations will be followed by a discussion of lipids and signaling molecules from the perspective of maternal dyslipidemia, cellular signaling and delivery of lipid to the fetus. Program: I. Maternal dyslipidemia in pregnancy: Vicki Clifton 20 min Title: Dyslipidemia in pregnancies complicated by asthma. Think before we supplement? Christiane Albrecht 10 min Title: Associations between cholesterol blood levels, placental lipid content and expression of cholesterol transporters in healthy and diseased placentas II. Lipids as signaling molecules that regulate placental growth and function: Leonardo Ermini 10 min Title: on "Sphingolipid compartmentalization in Preeclampsia "


Sarah Chauvin 10 min Title: Transforming Growth Factor Beta 3 (TGFβ3): A Novel Regulator of Ceramide Metabolism in the Human Placenta Irving Aye 10 min Title: “Adiponectin regulates trophoblast function through modulation of ceramide levels” III. Placental transport of lipids: Perrie O-Tierney-Ginn 20 min Title: Effects of maternal obesity on placental fatty acid uptake: Does fetal sex matter? Susanne Lager 10 min Title: Alterations in fatty acid transport protein expression in placental microvillous and basal membranes in pregnancies complicated by high maternal BMI. IV. Discussion led by moderators– 30 min Lipids as signaling molecules: maternal levels, intracellular regulators, fetal delivery. Is there a need for standard definition of dyslipidemia in pregnancy? Dietary fats – guidelines for pregnancy? Extracellular and intracellular lipid signaling molecules as regulators of placental function – importance in normal and pathological pregnancies. How are lipids transported to the fetus across the basal membrane? NEFAs vs Lipoproteins?


Workshop 2.4: Oxygen in placental development and pathologies

Date: Friday, September 13, 2013 Time: 8:30 am – 10:30 am Organizers: Alessandro Rolfo (Turin) and Charles Graham (Kingston) Workshop type: Specific problem areas and Advances. It is well established that Oxygen is a key player in both physiological and pathological placental development. Fine tuning of maternal-placental oxygen drives trophoblast proliferation, differentiation and invasion throughout pregnancy. Several molecular oxygen-targets have already been described in the human placenta and new ones are continuously discovered as culprits of severe pregnancy-related disorders such as preeclampsia and fetal growth restriction. Placental oxygen has also a pivotal clinical significance, being critical for fetal development and health. Indeed, oxygen is a fascinating protagonist of obstetric research and clinical life. One of the main problems of oxygen-related investigation is to find the appropriate in-vitro and in-vivo methodologies to study this powerful gas in the extremely sensitive environment of the placental tissue. The main aims of the present workshop are to present the latest advances in placental oxygen research and, in particular, to describe tools, experimental methods and in-vitro models available to investigate placental oxygen in both physiological and pathological condition,s as well as clinical tools to monitor in-vivo fetal-placental oxygenation. Workshop format: Problem discussion. Workshop where a specific problem/question is posed and various techniques can be employed to formulate answers, including groups and brainstorming sessions. The Speakers will present their work particularly focusing on the experimental approaches and innovative methodologies used to reach their goals. Workshop attendants will be asked to actively participate in the discussion by asking in advance specific questions related to placental oxygen investigation and methodological doubts. Outcomes: Besides presenting the latest advances in specific fields, the Workshop aims to define the best methodological approaches to investigate and monitor placental oxygenation in both physiological and pathological conditions. Thus, we will provide a technical guide and useful methodological hints for basic and clinical research investigators approaching the exciting world of oxygen. Speakers: - Alessandro Rolfo & TBA: Introduction to the Placental Oxygen World - Sruthi Alahari: “JMJD6: A Novel Oxygen Sensor in the Human Placenta” - Alexander Serov: “Modelling Oxygen Transport in the Human Placenta” - Carlos Salomon: “Hypoxia-Induced Changes In The Bioactivity Of Cytotrophoblast-Derived Exosomes”


Workshop 3 Workshop 3.1: Placental imaging: Insights into current and future modalities Date: Saturday, September 14, 2013 Time: 3:00-5:00 pm Organizers: Andrée Gruslin (Ottawa) and Tullia Todros (Turin) 1. Ultrasound based technology:

A. This section will address 2D and 3D sonography in the context of normal placental growth and development and in the evaluation of placental pathologies. Will cover evaluation of anatomy and of volume

B. This section will cover Doppler related imaging. Will review how power Doppler and color flow can help in diagnoses of placental abnormalities including IUGR, tumours, accreta and in evaluation of vascularization , comparison of vasculature and volume, prediction of adverse outcomes .(eg. Placenta. 2012 Oct;33 and using 4D Power: Ultrasound Med Biol. 2012 Aug;38(8):1345-51., Arch Gynecol Obstet. 2012 Feb;285(2):331-7. Placenta. 2011 Mar;32(3):230-4

2. MRI based technology This section will review use of MRI in the evaluation of invasive placental disease (accrete) and

compare with sonography and will also provide an overview of use of MRI in evaluation of placental function/perfusion and of hypoxia (see appended papers)

3. Imaging in animal research This section will focus on imaging of the placenta in animal models and will discuss the use of

sonography, contrast enhanced ultrasound and MRI , CT, MRI (eg. Radiology. 2013 May 21 Invest Radiol. 2013 Jul;48(7):535-42. Invest Radiol. 2013 Jan;48, BJOG. 2012 Apr;119(5):626-33.

Partial list of speakers: Drs. Todros, Salafia, Chen, Adamson, Collins, Gruslin


Workshop 3.2: Stem cells: From biology to pathology Sponsored by Insception Biosciences Date: Saturday, September 14, 2013 Time: 3:00-5:00 pm Organizers: Bill Kalionis (Melbourne) and Mohamed Abumaree (Riyadh) Our understanding of the role of stem cells in placental pathologies remains focussed on the many important derivatives of cytotrophoblast stem cells. Recent studies have described many new human stem cell types (i.e. mesenchymal, haematopoietic, endothelial, epithelial) in the placenta and fetal membranes. Understandably, initial studies concentrated on basic characterisation of these new stem cell types, and in the case of mesenchymal and epithelial stem cells, their potential for therapeutic applications. Now, attention has turned to the function of these newly discovered human stem cells in normal placental developmental and their potential contribution to important placental pathologies. Animal models, which have been pivotal in our understanding of trophoblast function, will play a similar role in the elucidation of the role of the function of new types of stem cell types. Together, the above studies are likely to add new stem cells as significant players in our paradigm for normal placental development and the aetiology of placental pathologies. This workshop on placental stem cells will be an opportunity not only to discuss the function of human stem cells in normal placental development and in pathologies, but also to hear about the latest in human cell culture and animal models that are appropriate for their functional analysis. We hope this workshop will be an occasion to exchange ideas and to address the many unanswered questions regarding placental stem cells. The workshop program will reserve time for discussion and idea exchange. We invite participants to provide their input in the hope that this will encourage future new avenues of investigation. We think that this workshop will be of interest to both beginners as well as to more specialized scientists in this field. Therefore, we invite IFPA attendees to join us in this workshop. Because stem cells cover a range of studies, we will commence with talks from invited speakers in the field and include short presentations of the abstracts submitted for this workshop and then have a general discussion on the open issues in this field. Session Chairs: Bill Kalionis, Royal Women’s Hospital, Australia; Dr Mohamed Abumaree, King Saud Bin Abdulaziz University for Health Sciences/King Abdullah International Medical Research Center, Riyadh Saudi Arabia. The Workshop program is organized as follows: Confirmed speakers: 3x(15min+5min) 1) "Preeclamptic Mesenchymal Stem Cells: Molecular Hallmarks of Pathogenesis" Allesandro Rolfo,

University of Turin, Italy 2) "Exosomal Signaling During Hypoxia Mediates Microvascular Endothelial Cell Migration and

Vasculogenesis" Carlos Gallo, University of Queensland Centre for Clinical Research, Australia 3) Decidual Mesenchymal Stem Cells: Do they play a role in the Pathogenesis of Preeclampsia?” Bill

Kalionis, Royal Women’s Hospital, Australia Speakers (short talks from abstracts): (7mins + 3 min)


1) “Differentiation of placental mesenchymal stromal cells into vascular endothelial cells” Michael Litvack,

University of Toronto, Canada 2) “p18 Contributes to Aberrant Cyclin-D1 Expression in Preeclamptic Placental Mesenchymal Stromal Cells

(PDMSCs)” Anna Maria Nuzzo, University of Turin, Italy 3) “Generation of cytotrophoblast-like cells from human embryonic stem cells in defined media” Yungchin

Li, UC San Diego, USA 4) “Lost in Transcription: A Comparative Microarray Analysis of the Trophoblast Stem Cell Niche in Mouse

and Human” Matteo Moretto-Zita, UC San Diego, USA Roundtable guided by the two chairs (10 minutes) Composition of 2 hour workshop 3 (15+5min) + 4(7+3min) + 20 mins general discussion= (120 mins)


Workshop 3.3: Bioinformatics tools for gene expression analysis

Date: Saturday, September 14, 2013 Time: 3:00-5:00 pm Organizers: Douglas Kniss, The Ohio State University; Brian Cox, University of Toronto

Speakers: William Ackerman (The Ohio State University), Brian Cox (University of Toronto), Joseph Huang (The Ohio State University), Douglas Kniss (The Ohio State University) and Yoel Sadovsky (University of Pittsburgh) Introduction - Douglas Kniss Précis The advent of high-content gene expression tools, including microarrays, Next Generation RNA sequencing (RNA-seq), Nanostring, Ion Torrent and other platforms offers researchers the ability to evaluate large datasets for systems biology analysis of complex biological pathways. Normalization, standardization, statistical assessment, pathway analysis, and the enormous volume of high-throughput data make accurate and precise evaluation a non-trivial challenge in modern biology. Topics discussed in this workshop will highlight practical, real-time experiences from messenger RNA and microRNA expression experiments. In addition, a hands-on exercise in the use of several web-based informatics platforms will be conducted to demonstrate a typical gene expression analysis workflow. Nanostring, RNA-seq and other high-dimensional platforms - William Ackerman Précis Increasingly, RNA-Seq and the NanoString nCounter system are being adopted for high-dimensional transcriptional profiling. These platforms both offer certain advantages over traditional microarrays, including increased sensitivity, expanded dynamic range, information regarding absolute transcript expression levels, and reduced signal-to-noise ratio. Expanding use of these technologies has led to the development of a host of novel bioinformatics and biostatistics algorithms for differential expression analyses; at present, however, there is little consensus for a single preferred method. In this workshop, we will present an overview of RNA-Seq and NanoString technologies, illustrating with examples some analysis strategies currently available in R and Bioconductor. Bioinformatics Workflows - Brian Cox Précis Many software packages exist for the processing of microarray data, from array normalization and value extraction to gene set enrichment calculation. However, it can be cumbersome to reformat data amongst these different platforms and rerunning a process is time-consuming. For these reasons the statistical and graphical scripting language of R (http://www.r-project.org/) combined with the available packages from Bioconductor (http://www.bioconductor.org/) offers a one-stop shop for processing of microarray data as well as most other data types. This seminar is intended to show the utility of learning the R language and to demystify and remove the fear barrier to learning programming languages. Specifically, I will present an example work flow that covers: power analysis to determine sample size, array processing, quality control, de-noising, and exploratory analysis.


mRNA Gene Expression Data - Joseph Huang Précis The birth of microarray analysis in the ‘90s initiated the high-throughput systems biology era. This technology provides researchers with opportunities to evaluate global changes in gene expression and pinpoint specific gene regulatory pathways. Topics discussed in this workshop will focus on the principle of the array design, the workflow of sample preparation and data analysis as well as the interpretation of the results. microRNA Gene Expression Data - Yoel Sadovsky Précis The expression of at least half of the human genes is thought to be regulated by microRNA (miRNAs), non-coding RNA molecules, acting through mRNA degradation or inhibition of protein translation. Most miRNAs regulate gene networks by preventing stochastic gene activation and thereby maintaining homeostasis. The discussion will center on a rigorous approach to analysis of miRNA function. Summary and Q &A - Panel


Workshop 3.4: Evolutionary approaches to understanding preeclampsia: The view from the placenta Date: Saturday, September 14, 2013 Time: 3:00-5:00 pm Organizers: Derek Wildman (Detroit) and Anthony Carter (Odense) Title: Evolutionary approaches to understanding preeclampsia: the view from the placenta Abstract: Among primates, the depth of trophoblast invasion in humans is matched only in chimpanzees and gorillas. Preeclampsia, too, is a disease of human pregnancy obstetrical syndrome and that has often been linked to the depth of trophoblast invasion. The workshop will explore whether placental evolution can be linked to preeclampsia using genomic data and information on the placental transcriptome. Speakers and topics: Anthony M. Carter (Odense, Denmark): Introduction: Evolution of placental invasiveness in primates. Derek E. Wildman (Detroit, Michigan): The relationship between adaptive evolution in protein coding genes and gene expression. Michael R. McGowen (Detroit, Michigan): The placental transcriptome. Michael G. Elliot (Vancouver, B.C.): The placental transcriptome. Stacy Zamudio (Hackensack, NJ): Concluding: Is placental blood flow really lower in preeclampsia?


Appendix B – New Investigator Oral Sessions New Investigator Oral Session 1 11:00am – 12:15pm Whistler Conference Centre Sea to Sky Ballroom A Thursday, September 12, 2013 Sponsored by Women and Children’s Health Research Institute, University of Alberta Chairs: Charles Graham PhD (Canada) and Larry Chamley PhD (NZ) Each speaker has 10 minutes + 5 min for questions. 1. NI.12 11:00am – 11:15am “The NAD-dependent deacetylase Sirtuin-1 regulates trophoblast differentiation and placental development” Kanaga Arul Nambi Rajan, University of California San Diego, La Jolla, California, USA 2. NI.6 11:15am – 11:30am “Transforming Growth Factor Beta 3 (TGFβ3): A Novel Regulator of Ceramide Metabolism in the Human Placenta” Sarah Chauvin, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada 3. NI.13 11:30am – 11:45am “Macrophage-derived interleukin-33 is a critical factor for placental growth” Valerie Fock, Medical University of Vienna, Vienna, Austria 4. NI.5 11:45am – 12:00pm “Replication Timing Predicts Underreplicated Domains in Polyploid Trophoblast Giant Cells” Roberta Hannibal, Stanford University School of Medicine, Stanford, CA, USA 5. NI.7 12:00pm – 12:15pm “Maternal uterine secreted mediator, VEGF, enhances embryo development and implantation” Natalie Hannan, Dept. Zoology, University of Melbourne, Parkville, Victoria, Australia


New Investigator Oral Session 2 11:00am – 12:00pm Whistler Conference Centre Sea to Sky Ballroom A Friday, September 13, 2013 Sponsored by Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research Chairs: Anthony Carter PhD (Denmark) and Theresa Powell PhD (US) Each speaker has 10 minutes + 5 min for questions. 1. NI.9 11:00am – 11:15am “p18 Contributes to Aberrant Cyclin-D1 Expression in Preeclamptic Placental Mesenchymal Stromal Cells (PDMSCs)” Anna Maria Nuzzo, Deptartment of Surgical Sciences, University of Turin, Turin, Italy 2. NI.11 11:15am – 11:30am “Decidual mesenchymal stem cells have reduced resistance to oxidative stress in preeclampsia, which is restored by the aldehyde dehydrogenase agonist Alda-1” Gina Kusuma, University of Melbourne Department of Obstetrics and Gynaecology and Department of Perinatal Medicine Pregnancy Research Centre, Royal Women's Hospital, Australia 3. NI.10 11:30am – 11:45am “Mass Spectrometry Imaging of Sphingolipids in Preeclamptic Placentae” Leonardo Ermini, Hospital for Sick Children Research Institute, Toronto, Canada 4. NI.1 11:45am – 12:00pm “The yolk sac of Necromys lasiurus (Rodentia, Cricetidae) as a promising source of mesenchymal stem cells” Phelipe Favaron, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil


New Investigator Oral Session 3 11:00am – 12:00pm Whistler Conference Centre Sea to Sky Ballroom A Saturday, September 14, 2013 Chairs: Andrée Gruslin MD, FRCSC (Canada) and Annetine Staff MD PhD (Norway) Each speaker has 10 minutes + 5 min for questions. 1. NI.4 11:00am – 11:15am 10 minutes + 5 min for questions) “Gene Expression Differences Reveal Ancestry-Specific Environmental Interactions in Placental Adaption to High-Altitude Hypoxia” William E. Gundling, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA 2. NI.8 11:15am – 11:30am “Docosahexaenoic Acid (DHA) Supplementation Decreases Inflammatory Signaling in Placenta from Obese Women” Susanne Lager, Department of Obstetric and Gynaecology, University of Texas Health Science Center, San Antonio, Texas, USA 3. NI.3 11:30am – 11:45am “Identification of candidate genes in human placenta involved in the development of childhood allergy” Astrud Tuck, University of Adelaide, Adelaide, South Australia, Australia 4. NI.2 11:45am – 12:00pm “Intra Placental Gene Transfer of Ad-hIGF-1 in a Mouse Model of Placental Insufficiency (PI) Corrects Liver Growth Factor Expression ( IGFBP-1)” Khaled Omar, Cincinnati Childrens Hospital Medical Centre, Cincinnati, Ohio, USA


Appendix C - Poster Session 1

P1.1

Decidual acute atherosis- updating and testing diagnostic criteria Patji Alnæs-Katjavivi1, Fiona Lyall2, Borghild Roald4, Christopher Redman3, Annetine Staff1, 1Women and Children's Division, Oslo University Hospital (OUS), Oslo, Norway, 2Institute of Medical Genetics, University of Glasgow, Glasgow, UK, 3Nuffield Department of Obstetrics&Gynaecology, University of Oxford, Oxford, UK,

4Department of Pathology, Oslo University Hospital (OUS), Oslo, Norway

P1.2

Abnormal pericyte recruitment in fetal placental vasculature: cause of IUGR and fetal thrombotic vasculopathy in Adams-Oliver syndrome? Christof Senger1,2, 1Children's & Women"s Health Centre of BC, BC, Canada, 2University of British Columbia, BC, Canada

P1.3

Myonecrosis in umbilical cord and chorionic plate blood vessels Maria Paola Bonasoni1, Geoff Machin1, Farah Tabassum1, Patrick Shannon1, Glenn Taylor2, Sarah Keati ng1, 1Mount Sinai Hospital, Toronto, Canada, 2Hospital for Sick Children, Toronto, Canada

P1.4

Does "beta" exist in twin pregnancies? Comparisons of monochorionic and dichorionic twins, and correlations with placental efficiency Mary Park1, Michael Yampolsky2, Oleksandr Shlakhter2,3, Samantha VanHorn1, Beata Dygulska1, Nora Kiryankova1, H Inany1, Pradeep Charlagorla1, Carolyn Salafia1,4, 1New York Methodist Hospital, Brooklyn, NY, USA, 2University of Toronto, Toronto, Ontario, Canada, 3Alberta Health Services, Edmonton, Alberta, Canada,

4Institute for Basic Research, Staten Island, NY, USA

P1.5

Vascular Network Features, Separate from Anastomotic Communications, Account for Birthweight Discordance in Monochorionic Placentas Moni Kaneti1, Enrico LoPriore3, Nadav Schwartz4, Dawn Misra5, Carolyn Salafia1,2, 1Placental Analytics LLC, Larchmont, NY, USA, 2Institute for Basic Research, Staten Island, NY, USA, 3Leiden University Hospital, Leiden, The Netherlands, 4University of Pennsylvania SChool of Medicine, Philadelphia PA, USA, 5Wayne State University, Detroit, MI, USA

P1.6

Placental terminal villi complexity in cases of autism/autism spectrum disorder (ASD) and their matched controls Carolyn Salafia1,2, George Merz1, Craig Platt3, 1Institute for Basic Research, Staten Island, NY, USA, 2Placental Analytics LLC, Larchmont, NY, USA, 3University Hospitals Bristol NHS Foundation Trust, Bristol, UK

P1.7

The majority of variance in birthweight relative to placental weight (as beta=ln(PW)/ln(BW) is accounted for by detailed novel placental measures: implications for fetal origins work Carolyn Salafia1,2, Dawn Misra1,2, C Stodgell2,3, P Katzman2,3, L Ruffolo2,3, J Culhane2,4, S Wadlinger2,4, R Wapner2,5, C Torres2,5, P Landrigan2,6, L Littman2,6, P Sheffield2,6, S Leuthner2,7, S Szabo2,7, N Thieux2,8, B Specker2,8, J Swanson2,9, RK Miller2,3, John Moye2,13, M Durkin2,12, 1Placental Analytics LLC, Larchmont, NY, USA, 2National Children's Study Placenta Consortium, Bethesda MD, USA, 3University of Rochester School of Medicine and Dentistry, Rochester NY, USA, 4The Children’s Hospital of Philadelphia, Philadelphia PA, USA,

5Columbia University, New York, NY, USA, 6Icahn Schhol of Medicine, New York, NY, USA, 7Medical College of Wisconsin, Milwaukee, WI, USA, 8South Dakota State University, Brookings, SD, USA, 9University of California at Irvine, Irvine, CA, USA, 10University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 11University of Utah, Salt Lake City, UT, USA, 12university of Wisconsin, Madison, WI, USA, 13NIH/National Children’s Study, Bethesda MD, USA


P1.8

Porous media flow models for maternal placental circulation Christopher Ball1, David Grynspan2, Andree Gruslin3,4, 1Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada, 2Department of Pathology and Laboratory Medicine, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada, 3Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa, Ontario, Canada, 4Department of Cellular Molecular Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada

P1.9 Echocardiographic analyses of pregnancies in the placental growth factor knockout mouse Kristiina Aasa1, Bruno Zavan1,2, Philip Wong1, Yat Tse1, Stephen Pang1, B. Anne Croy1, 1Queen's University, Kingston, ON, Canada, 2UNIFAL-MG, Alfenas, Minas Gerais, Brazil

P1.10

Immunological placental injury as a common feature of chromosomally normal and abnormal miscarriages: Placental C4d and decidual plasmacytes Joong Yeup Lee1, Joon-Seok Hong2,6, Eun Na Kim3,6, Soyeon Ahn4, Jin Choe1, Doyeong Hwang1, Ki Chul Kim1, Seok Hyun Kim5, Chong Jai Kim3,6, 1Hamchoon Women’s Clinic, Seoul, Republic of Korea, 2Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea,

3Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, 4Medical Research Collaborating Center, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea, 5Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea, 6Asan Laboratory of Perinatal Science, Asan Institute for Life Sciences, Seoul, Republic of Korea

P1.11

Comparative placentation in the spiny rat Thrichomys laurentinus (Rodentia, Hystricognathi, Echimyidae) Moacir de Oliveira1, Phelipe Favaron2, Maria Angelica Miglino2, Andrea Mess2, 1Department of Animal Science, Universidade Federal Rural do Semi-Árido, Mossoró, Rio Grande do Norte, Brazil, 2Department of Surgery, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

P1.12

Development of yolk sac inversion in caviomorph rodents Moacir de Oliveira1, Phelipe Favaron2, Bruno Vasconcelos2, Maria Angelica Miglino2, Andrea Mess2, 1Department of Animal Science, Universidade Federal Rural do Semi-Árido, Mossoró, Rio Grande do Norte, Brazil, 2Department of Surgery, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil

P1.13

Poly (ADP-Ribose) Polymerase-1 (PARP-1) induces trophblast syncytialization Justin Pater1, Girish Shah2, Daniel MacPhee1, 1University of Saskatchewan, Saskatoon, Saskatchewan, Canada, 2Laval University, Quebec City, Quebec, Canada

P1.14

Proton-Assisted Amino Acid Transporter 1 (PAT1) is Required for Amino Acid Sensing by Mammalian Target of Rapamycin Complex 1 (mTORC1) in Primary Human Trophoblast Cells Irving Aye1, Theresa Powell1, Deborah Goberdhan2, Thomas Jansson1, 1University of Texas Health Science Center, San Antonio, USA, 2University of Oxford, Oxford, UK

P1.15

Advanced oxidation protein products in the plasma and placenta of normal pregnant women and women with preeclampsia Qi-tao Huang1, Shuo-shi Wang1, Jian-hong Chen1, Mei Zhong1, Jian-wei Tian2, Yan-hong Yu1, Zhi-jian Wang1, Li-ping Huang1, Ning Fu3, Fan-fan Hou2, Min Zhang1, 1Division of Obstetrics And Gynecology, Guangzhou, China, 2Division of Nephrology, Guangzhou, China, 3Department of Immunology, School of Basic Medical Sciences, Guangzhou, China


P1.16

Increased plasma and placental advanced oxidation protein products levels in gestational diabetes mellitus with placental vascular complications Qi-tao Huang1, Shuo-shi Wang1, Mei Zhong1, Jian-wei Tian2, Yan-hong Yu1, Zhi-jian Wang1, Li-ping Huang1, Ning Fu3, Fan-fan Hou2, Min Zhang1, 1Division of Obstetrics And Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China, 2Division of Nephrology, Key Laboratory for Organ Failure Research, Nephrology Research Center of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China, 3Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China

P1.17

Sexual dimorphism starting from the blastocyst stage in response to an imbalanced maternal diet in a rabbit model Anne Tarrade1,2, Delphine Rousseau-Ralliard1,2, Marie-Christine Aubrière1,2, Nathalie Peynot1, Michèle Dahirel1,2, Justine Bertrand-Michel3, Tiphaine Aguirre-Lavin1, Olivier Morel1,2, Nathalie Beaujean1, Véronique Duranthon1, Pascale Chavatte-Palmer1,2, 1INRA, UMR 1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France, 2Fondation PremUp, Paris, France, 3INSERM, UMR 1048, I2MC, Toulouse, France

P1.18

Maternal obesity: gender-specific differences in placental pathology Sandra Leon-Garcia1, Katharine Knepper1, Hilary Roeder1, Louise C. Laurent,1, Yvette LaCoursiere1, Mana Parast1, 1University of California, San Diego, San Diego, California, USA

P1.19

The G protein coupled receptor 55 in the human placenta and the role of its endogenous agonist lysophosphatidylinositol (LPI) on endothelial function Julia Kremshofer1, Gerit Moser1, Monika Siwetz1, Astrid Blaschitz1, Monika Sundl1, Berthold Huppertz1, Martin Gauster1, 1Medical University of Graz, Graz, Austria

P1.20

Metalloproteinase dependent secretion of placental fractalkine Martin Gauster1, Monika Siwetz1, Astrid Blaschitz1, Veronika M. Berghold1, Gerit Moser1, Jelena Bilic1,2, Julia Kremshofer1, Berthold Huppertz1, 1Medical University Graz, Institute of Cell Biology, Histology and Embryology, Graz, Austria, 2Medical University Graz, Department of Obstetrics and Gynecology, Graz, Austria

P1.21

Fetal HDL-associated apoM-S1P complex mediates vasoprotective action on the feto-placental endothelium. In Gestational Diabetes Mellitus (GDM) endothelial barrier integrity is impaired Ivana Sreckovic1, Nicole Gabriele Sommer1, Eva Bernhart2, Wolfgang Sattler2, Gernot Desoye1, Uwe Lang1, Christian Wadsack1, 1Medical University Graz, Department of Obstetrics and Gynaecology, Graz, Austria,

2Medical University Graz, 2Department of Medical Biochemistry, Institute of Molecularbiology and Biochemistry, Graz, Austria

P1.22

Placental abnormalities in hypoplastic left heart syndrome are both trophoblastic and endothelial Helen Jones1, Stephanie Olbrych1, Robert Hinton Jr.1, 1Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

P1.23

IGF-1 over-expression following intra-placental Ad-hIGF-1 maintains essential amino acid supply by altering LAT1 protein turnover Weston Troja1, Charles Klanke1, Helen Jones1, 1Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

P1.24

Co-culture of isolated human placental microvascular cells with trophoblast cells significantly alters their angiogenic profile Kicheol Kil1, Helen Jones2, 1Yeouido St. Mary’s Hospital, The Catholic University of Korea, Seoul,, Republic of Korea, 2Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA


P1.25

The PcG gene Sfmbt2 regulates development of extraembryonic stem cells and tissues Kamelia Miri1, Keith Latham2, Caroline Dunk3, Susannah Varmuza1, 1University of Toronto, Toronto, Ontario, Canada, 2Temple University School of Medicine, Philadelphia, PA, USA, 3Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada

P1.26

Expression and function analysis of miR-141 in trophoblastic cell lines Stephanie Ospina-Prieto1, Diana Morales-Prieto1, Wittaya Chaiwangyen1, Ekkehard Schleussner1, Udo R Markert1, 1Placenta-Lab, University Hospital Jena, Jena, Germany

P1.27

VEGF inhibits BMP9 induced ET-1 production by blocking p38 phosphorylation Valentin Sotov1,2, Michelle Letarte1,2, 1Department of Immunology, University of Toronto, Toronto, ON, Canada, 2Molecular Structure and Function Program, Toronto, ON, Canada, 3Heart and Stroke Richard Lewar Center of Excellence, Toronto, ON, Canada

P1.28

Sildenafil citrate increases fetal and placental weight in the placental specific Igf2 knockout (P0) mouse Mark Dilworth1, Irene Andersson2, Elizabeth Cowley1, Lewis Renshall1, Philip Baker3, Susan Greenwood1, Colin Sibley1, Mark Wareing1, 1University of Manchester, Manchester, UK, 2University of Alberta, Edmonton, Canada, 3University of Auckland, Auckland, New Zealand

P1.29

The role of CDX2 in trophoblast differentiation from human pluripotent stem cells Chi-Wei Lu1, Yasunari Seita1, 1Rutgers University, New Brunswick, NJ, USA

P1.30

Endothelial dysfunction of the fetoplacental circulation contributes to the increased vascular resistance observed in fetal growth restriction Sarah Jones1, Helen Bischof1, Edward Johnstone1, Sue Greenwood1, Mark Wareing1, Colin Sibley1, Paul Brownbill1, 1University of Manchester, Manchester, UK

P1.31

Maternal administration of Sildenafil Citrate alters fetal vascular function in a mouse model of fetal growth restriction Lewis Renshall1, Elizabeth Cowley1, Susan Greenwood1, Mark Dilworth1, Mark Wareing1, 1Maternal and Fetal Research Centre, The University of Manchester, Manchester, UK

P1.32

Inflammation-induced fetal growth restriction and pre-eclampsia are linked to alterations in placental morphometrics in a rat model Tiziana Cotechini1, Shannyn K. Macdonald-Goodfellow1, Charles H. Graham1, 1Queen's University, Kingston, Ontario, Canada

P1.33

Temporal dynamics of the placental transcriptome Siim Sõber1, Mario Reiman1, Kristiina Rull1,2, Pille Vaas2, Jaana Männik1,3, Maris Laan1, 1Human Molecular Genetics Group, Institute of molecular and cellular biology, University of Tartu, Tartu, Estonia, 2Department of Obstetrics and Gynecology, Tartu University Hospital, Tartu, Estonia, 3Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, USA

P1.34

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta Malgorzata Gasperowicz1, Anshita Rai1, James Cross1, 1University of Calgary, Calgary, Alberta, Canada

P1.35

Placental adaptations in response to protein restricted diet Malgorzata Gasperowicz1, Paula Gonzalez1,2, Benedikt Hallgrímsson1,3, James Cross1, 1University of Calgary, Calgary, Alberta, Canada, 2Instituto de Genética Veterinaria, UNLP-CCT La Plata, CONICET, La Plata, Buenos Aires, Argentina, 3McCaig Institute for Bone and Joint Health, Calgary, Alberta, Canada


P1.36

Altered placental mRNA's profile of Neurotrophic and Growth Factors in Preeclampsia Aridahyd Montero-Rojas2, Francisco-Javier Alvarado-Gay2, Ricardo Juárez-Ocaña1, José-Vicente Rosas-Barrientos3, Daniel Martínez-Fong5, Juan-Antonio González-Barrios4, 1Coordinación de Capacitación, Desarrollo e Investigación, Mexico D. F., Mexico, 2Coordinación de Ginecología y Obstetricia, Mexico D. F., Mexico, 3Investigación, Mexico D. F., Mexico, 4Laboratorio de Medicina Genómica, Hospital Regional “Primero de Octubre" ISSSTE, Mexico D. F., Mexico, 5Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV, Apartado postal 14-740, Mexico D. F., Mexico

P1.37

Genetics of glycoprotein hormone Stanniocalcin-1 and link to pregnancy complications Peeter Juhanson1, Kristiina Rull1,2, Triin Kikas1, Pille Vaas2, Pille Teesalu2, Maris Laan1, 1Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, 2Department of Obstetrics and Gynecology, Tartu University Hospital, Tartu, Estonia

P1.38

Gene expression in the term placenta of the opossum Monodelphis domestica and the evolution of the therian placenta Michael R. McGowen1, Amy Weckle1, Dalen Agnew2, Kurt Benirschke3, Sue Savage-Rumbaugh4, Chong Jai Kim5,7, Günter P. Wagner6, Robert Romero7, Derek E. Wildman1,8, 1Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA, 2Diagnostic Center for Population and Animal Health, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA,

3Department of Pathology, University of California, San Diego, San Diego, CA, USA, 4Great Ape Trust/Bonobo Hope Sanctuary, Des Moines, IA, USA, 5Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA, 6Department of Ecology and Evolutionary Biology and Yale Systems Biology Institute, Yale University, New Haven, CT, USA, 7Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Detroit, MI, USA,

8Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA

P1.39

Placental mesenchymal dysplasia associated with androgenetic/biparental mosaicism Atsuko Hichijo1, Mikio Morine1, 1Department of Maternal Fetal Medicine, Center for Maternal, Fetal and Neonatal Medicine, National Hospital Organization, Kagawa Children's Hospital, Zentsuji, Japan

P1.40

RAP1 functions as a mediator of EGF singaling pathway and a regulator of EGF receptor in extravillous trophoblast cells invasion Mikihiro Yoshie1, Kazuya Kusama1, Kensuke Ohishi1, Kazuhiro Tamura1, Hirotaka Nishi2, Keiichi Isaka2, Masahiko Kutsukake1, Eiichi Tachikawa1, 1Department of Endocrine and Neural Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan, 2Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan

P1.41

Unfractionated heparin reverses the increased thrombin generation associated with decorin deficiency in fetal growth restriction Amy Chui1, Tilini Gunatillake1,2, Padma Murthi2, Vera Ignjatovic3,4, Paul Monagle3,4, John Whitelock5, Shaun Brennecke2, Joanne Said1, 1Department of Medicine, The University of Melbourne, St Albans, Victoria, Australia, 2Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia, 3Department of Pediatrics, The University of Melbourne, Parkville, Victoria, Australia, 4Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia, 5Graduate School of Biomedical Engineering, University of New South Wales, Kensington, New South Wales, Australia

P1.42

Variation in glucocorticoid receptor isoforms expression and function: A possible force driving Glucocorticoid resistance among male fetal placental unit in pregnancies complicated with asthma Zarqa Saif1, Nicolette Hodyl1, Eleanor Hobbs1, Astrud Tuck1, Vicki Clifton1, 1university of Adelaide, Adelaide, south australia, Australia


P1.43

Effect of L-NAME on sub-cellular distribution of eNOS and caveolin-1 in the perfused human placenta Lopa Leach1, Vishal Ghori1, 1University of Nottingham, Nottingham, UK

P1.44

Oxidative stress induces smooth muscle dedifferentiation in placental stem villus arteries through reduced hydrogen sulphide production by cystathionine-γ-lyase Liangjian Lu1, Graham J Burton1, Tereza Cindrova-Davies1, 1University of Cambridge, Cambridge, UK

P1.45

Function of survivin in trophoblastic cells of the placenta Cornelia Muschol-Steinmetz1, Alexandra Friemel1, Nina-Naomi Kreis1, Joscha Reinhard1, Juping Yuan1, Frank Louwen1, 1Department of Gynecology and Obstetrics, School of Medicine, J. W. Goethe-University, Frankfurt, Germany

P1.46

Reduced utrerine perfusion pressue does not influence the endocannabinoid system (ECBS) transcripts in the rate model Mauro Schenone1, Zorica Janjetovic1, Ramona Phinehas1, Brian Brocato1, Giancarlo Mari1, Robert Ahokas1, Andrzej Slominski1, Natalia Schlabritz-Loutsevitch1, 1University of Tennessee Health Science Center, Memphis, TN, USA

P1.47

Altered numbers of NK-cells in placental tissue of smokers versus non-smokers Andrea Klee1, Theresa Wagner1, Maja Weber1, Ekkehard Schleussner1, Udo R. Markert1, Justine S. Fitzgerald1, 1Placenta-Lab, Department of Obstetrics, University Hospital Jena, Jena, Germany

P1.48

Trophoblast debris shifts macrophage differentiation from inflammatory M1 to anti-inflammatory M2 macrophages: an aid to the immunosuppressive environment of human pregnancy Mohamed Abumaree1,2, Fawaz Abomaray2, Ahmed Al-Bawab1, Fawaz El-Muzaini3, Larry Chamley4, 1College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, National Guard Health Affairs, P.O. Box 22490, Riyadh 11426, Mail Code 1515, Riyadh, Saudi Arabia, 2King Abdullah International Medical Research Center, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia, 3Department of Obstetrics and Gynaecology, King Abdulaziz Medical City, Riyadh, Saudi Arabia, Riyadh, Saudi Arabia, 4Department of Obstetrics & Gynaecology, University of Auckland, Faculty of Medical and Health Sciences, 11, Private Bag 92019, Grafton, Auckland, New Zealand., Auckland, New Zealand

P1.49

Human placental mesenchymal stem cells (pMSCs) shift macrophage differentiation from inflammatory M1 to anti-inflammatory M2 macrophages: possible implication in inflammatory diseases Mohamed Abumaree1,2, Mohammed Al Jumah1,2, Bill Kalionis3, Dunia Jawdat1,2, Abdulaziz Al Khaldi1,2, Fawaz Abomaray2, Ahmed Melad2, Abulhamed Fatani1, Larry Chamley4, Bander Knawy1,2, 1College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, National Guard Health Affairs, P.O. Box 22490, Riyadh 11426, Mail Code 1515, Riyadh, Saudi Arabia, 2King Abdullah International Medical Research Center, King Abdulaziz Medical City, National Guard Health Affairs, P.O. Box 22490, Riyadh 11426, Mail Code 1515, Riyadh, Saudi Arabia, 3University of Melbourne, Department of Obstetrics and Gynaecology and Department of Perinatal Medicine Pregnancy Research Centre, Royal Women’s Hospital, Parkville, Victoria, Australia, 3052, Melbourne, Australia, 4Department of Obstetrics & Gynaecology, University of Auckland, Faculty of Medical and Health Sciences, 11, Private Bag 92019, Grafton, Auckland, New Zealand, Auckland, New Zealand

P1.50

TCDD and ITE differentially regulate the vascular remodeling of rat placenta via the activation of AhR Yanming Wu1, Xiao Chen1, Qizhi He3, Qian Zhou1, Tony Duan2, Kai Wang1, 1Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China, 2Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China, 3Department of Pathology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China


P1.51

Human amniotic fluid stem cells suppress PBMC proliferation through IDO and IL-10-dependent pathways Chengfeng Luo1, Wenwen Jia2, Kai Wang1, Fengli Chi1, Yanqiong Gu1, Xiaoling Yan1, Gang Zou1, Tao Duan1, Qian Zhou1, 1Clinical and Translational Research Center of Shanghai First Maternity and Infant Health, Shanghai, China, 2School of Life Science and Technology, Tongji University, Shanghai, China

P1.52

2-methoxyestradiol but not catechol-O-methyltransferase is correlated with preeclampsia Yanming Wu1, Zhijun Shen2, Xiao Chen1, Jian Zhou3, Kai Wang1, Tony Duan3, 1Clinical and Translational Research Center,Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China, 2Endocrinology Lab, Shanghai First Maternity and Infant Hospital,Tongji University School of Medicine, Shanghai, China, 3Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China

P1.53

Subcutaneous injection of orally tolerated proteins in the mother disturbs embryo implantation in mice Daniel Antero Galdino1, Geraldo Magela Azevedo-Junior1, Estela Maris Bevilacqua2, Nelson Monteiro Vaz1, Claudia Rocha Carvalho1, 1Universidade Federal de Minas Gerais, Belo Horizonte/MG, Brazil, 2Universidade de São Paulo, São Paulo, Brazil

P1.54

Visualization of human placental architecture by whole mount immunofluorescence microscopy Shawn Murphy1, Meghan Bushway1, Paula Zozzaro-Smith1, Bruce Fenton1, Richard Miller1, Edith Lord1, Scott Gerber1, 1University of Rochester, Rochester, NY, USA

P1.55

Characterization of interferon responses in human placental explants by whole mount immunofluorescence Shawn Murphy1, Meghan Bushway1, Scott Gerber1, Richard Miller1, Edith Lord1, 1University of Rochester, Rochester, NY, USA

P1.56

The role of Epac2-mediated calreticulin expression in human endometrial stromal cells decidualization Kazuya Kusama1, Mikihiro Yoshie1, Kazuhiro Tamura1, Takahiro Nakayama1, Hirotaka Nishi2, Keiichi Isaka2, Masahiko Kutsukake1, Eiichi Tachikawa1, 1Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan,

2Tokyo Medical University, Tokyo, Japan

P1.57

Trophoblast-endometrial interaction in a 3D culture system Volker U. Buck1, Fabia Flensberg1, Oliver Krings1, Rudolf E. Leube1, Birgit Gellersen2, Irmgard Classen-Linke1, 1RWTH Aachen University, Medical Faculty, Institute of Molecular and Cellular Anatomy, Aachen, Germany, 2Endokrinologikum Hamburg, Hamburg, Germany

P1.58

Inhibition of trophoblast migration by human cytomegalovirus involves impaired activation of PAR4 by the protease PAPP-A Benjamin Rauwel1, Stéphane Chavanas1, Melinda Bénard1,2, Alicia Grosso3,4, Jérome Carlier1, Hélène Martin1, Daniele Evain-Brion3,4, Nathalie Vergnole1, Christian Davrinche1, Nicolas Cenac1, Thierry Fournier3,4, 1U1043 INSERM, CNRS, Université Toulouse III Paul-Sabatier, Toulouse, France, 2Hôpital des enfants, service de néonatologie, CHU Purpan, Toulouse, France, 3UMR-S 767 INSERM, Université Paris Descartes, Paris, France,

4PremUp foundation, Paris, France

P1.59

LC-2MS analysis revealed 13-HODE as a major PPARg ligand produced in cytotrophoblasts upon infection by HCMV. Kaoutar Leghmari1, Benjamin Rauwel1, Helene Martin1, Pauline Le Faouder4, Justine Bertrand Michel4, Christian Davrinche1, Thierry Fournier2,3, Stephane Chavanas1, 1U1043 INSERM, CNRS, Université Toulouse III Paul-Sabatier, Toulouse, France, 2UMR-S767 INSERM, Université Paris Descartes, Paris, France, 3PremUp Foundation, Paris, France, 4U1048 INSERM, MetaToul-LIPIDOMIQUE, Toulouse, France


P1.60

Complement (C3d) deposition in the intervillous space of the placenta Alexander Padovano1,2, Michael Benson1, Robert Goldschmidt1, Ying Zhou1, 1NorthShore University HealthSystem, Evanston, Illinois, USA, 2Washington University in St. Louis, St. Louis, MO, USA

P1.61

Effect of induced inflammation in mice during pregnancy Bruno Zavan1, Eliana M. Almeida1, Eliana M. O. Lippe2, Alexandre Giusti-Paiva1, Aureo T. Yamada2, Valdemar A. Paffaro-Jr1, 1Federal University of Alfenas, Alfenas, MG, Brazil, 2University of Campinas, Campinas, SP, Brazil

P1.62

Functional Toll-like receptors in primary first trimester trophoblasts Line Haugstad Tangerås1,2, Guro Sannerud Stødle1,2, Guro Dalheim Olsen1, Ann-Helen Leknes1, Astrid Gundersen1, Bente Skei1, Anne Jorunn Vikdal1, Liv Ryan1, Bjørg Steinkjer1, Merete F. Myklebost3, Mette Langaas4, Rigmor Austgulen1, Ann-Charlotte Iversen1, 1Centre of Molecular Inflammation Research and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, 2Liaison Committee between the Central Norway Regional Health Authority (RHA) and NTNU, Trondheim, Norway, 3Department of Gynaecology and Obstetrics, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway, 4Department of Mathematical Sciences, NTNU, Trondheim, Norway

P1.63

Mechanisms in endovascular differentiation of the trophoblast and its regulation by decorin Peeyush Lala1, Gannareddy Girish1, 1university of Western Ontario, London, Ontario, N6A5C1, Canada

P1.64

RACK1 interacts with FBW2 to upregulate GCM1 stability and placental cell migration and invasion Hungwen Chen1, Chang-Chun Wang2, Hsiao-Fan Lo2, 1Academia Sinica, Taipei, Taiwan, 2National Taiwan University, Taipei, Taiwan

P1.65

Quantification of abnormal placental vasculature using 3D power Doppler ultrasound to detect placenta accreta and stratify the consequent clinical risk Sally Collins1,2, Gordon Stevenson3, Lawrence Impey2, Abdullah Al-Khan4, Nicholas Illsley4, Stacy Zamudio4, 1Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK, 2Fetal Medicine Unit, John Radcliffe Hospital, Oxford, UK, 3Institute of Biomedical Engineering, University of Oxford, Oxford, UK, 4Division of Maternal-Fetal Medicine and Fetal Surgery, Hackensack University Medical Center, Hackensack, USA

P1.66

N-cadherin, VCAM and CD162 mediate torphoblast cell adhesion to endothelial tubes on matrigel Tanja Groten1, Anna Weichold1, Udo Markert1, Ekkehard Schleussner1, Berthold Huppertz2, 1University Hospital Jena, Department of Obstetrics, Placentalabor, Jena, Germany, 2Medical University of Graz, Institute of Cell Biology, Histology and Embryology, Graz, Austria

P1.67

Preparation of extravillous trophoblast from the basal plate of term human placenta Nicholas Illsley1, Sonia DaSilva-Arnold1, Abdullah Al-Khan1, Stacy Zamudio1, 1Hackensack University Medical Center, Hackensack, NJ, USA

P1.68

Mitochondrial function in the murine placenta Josephine Higgins1, Andrew Murray1, Abigail Fowden1, Amanda Sferruzzi-Perri1, 1University of Cambridge, Cambridge, UK

P1.69

Evidence for altered sphingolipid content in membrane microdomains in preeclampsia Leonardo Ermini1, Megan Melland-Smith2, Martin Post1, Isabella Caniggia2, 1Hospital for Sick Children Research Institute, Toronto, Ontario, Canada, 2Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada


P1.70

Use of network biology to understand the effects of hyperglycemia on the trophoblast: a model of the placenta in diabetes mellitus Charlotte Hulme1, Adam Stevens2, Alexander Heazell1, Melissa Westwood1, Jenny Myers1, 1Maternal and Fetal Health Research Centre, School of Biomedicine, Manchester Academic Health Health Science Centre, University of Manchester, Manchester, UK, 2Department of Peadiatric Endocrinology, Manchester Academic Health Sciences Centre, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK

P1.71

Nutrient regulation of growth factor signalling in human placenta Raja Nadif1, Victoria Palin1, Colin Sibley1, John Aplin1, Melissa Westwood1, 1University of Manchester, Manchester, UK

P1.72

Effects of niacin supplementation on placental stress response Tasfia Ahmed1, Miesha Roberts MacDonald1, Bénédicte Fontaine-Bisson1, Shannon Bainbridge1, 1University of Ottawa, Ottawa, Ontario, Canada

P1.73

Effects of dietary soy on ethanol-impaired placentation and fetal growth Fusun Gundogan1,3, Wei Qi2, Jeffrey Gilligan2, Suzanne de la Monte2,3, 1Women and Infants Hospital, Providence, RI, USA, 2Rhode Island Hospital, Providence, RI, USA, 3Warren Alpert Medical School at Brown University, Providence, RI, USA

P1.74

Homing peptide-mediated targeting of liposomes to term villous explants: novel nanocarriers for targeted drug delivery Natalie Cureton1, Francesco Cellesi1, John Aplin1, Lynda Harris1, 1University of Manchester, Manchester, UK

P1.75

Is Helicobacter pylori infection a risk factor for miscarriage? Simona Cardaropoli1, Annalisa Piazzese1, Ettore Piccoli1, Alessandro Rolfo1, Tullia Todros1, 1Deptartment of Surgical Sciences, University of Turin, Turin, Italy

P1.76

Metabolic response of syncytiotrophoblast mitochondria to maternal obesity James Mele1, Alina Maloyan1, Leslie Myatt1, 1UTHSCSA, San Antonio, Tx, USA

P1.77

Sexual dimorphism in the effect of maternal adiposity on placental miR-210 expression Sribalasubashini Muralimanoharan1, Chunming Guo1, Leslie Myatt1, Alina Maloyan1, Center for Pregnancy and Newborn Research, Deptartment of Obstetrics & Gynaecology, University of Texas Health Science Center 1UTHSCSA, San antonio, USA

P1.78

Genome-scale analysis of the influence of maternal adiposity on the human placental epigenome. Kohzoh Mitsuya1, Lu Liu2, Jianhua Ruan2, Leslie Myatt1, 1Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, Texas, USA, 2Department of Computer Science, University of Texas at San Antonio, Texas, USA

P1.79

The Role of EGFL7 in trophoblast cells and endothelial cells during placental development Lauretta Lacko1, Heidi Stuhlmann1, 1Weill Cornell Medical College, New York, NY, USA

P1.80

Impaired interactions between decidual natural killer cells and trophoblast contribute to poor spiral artery remodelling Alison Wallace1, Amanda Host1, Guy Whitley1, Judith Cartwright1, 1St George's, University of London, London, UK

P1.81

Is mitochondrial DNA in trophoblast debris an inflammatory mediator relevant to preeclampsia? Kate Wauchop1, Jonathan Warren2, Larry Chamley1, Lynsey Cree1, Jo James1, 1University of Auckland, Auckland, New Zealand, 2St George's University of London, London, UK


P1.82

Characterisation of first trimester placental explant-derived mesenchymal stem cells Megan Alexander1, Larry Chamley1, Jo James1, 1University of Auckland, Auckland, New Zealand

P1.83

Trophoblast microparticles from placental explants treated with preeclamptic sera activate endothelial cells: Possible relevant to the pathogenesis of preeclampsia Qi Chen1,2, Fang Shen1,2, Jia Wei1, Peter Stone1, Saul Snowise1, Larry Chamley1, 1The University of Auckland, Auckland, New Zealand, 2Fudan University, Shanghai, China

P1.84

Free fetal haemoglobin elevates vascular tone in the fetoplacental circulation Adam Brook1, Stefan Hansson2, Bo Åkerström2, Henning Schneider3, Ingrid Lang4, Gernot Desoye4, Jenny Myers1, Ian Crocker1, Paul Brownbill1, 1University of Manchester, Manchester, UK, 2Lund University, Lund, Sweden, 3University of Bern, Berne, Switzerland, 4Medical University of Graz, Graz, Austria

P1.85

A combination of single nucleotide polymorphisms in the 3'untranslated region of HLA-G is associated with preeclampsia Stephanie Grover1, Kevin Quach1, Shlomit Kenigsberg1, Clifford Librach1, 1CReATe Fertility Centre, Toronto, Ontario, Canada

P1.86

Maternal serum levels of FGL2 as screening tool for preeclampsia Julien Yockell-Lelievre1, Barbara Vanderhyden1,2, Andree Gruslin1,3, 1Ottawa Hospital Research Institute, Ottawa, ON, Canada, 2Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada, 3Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa, ON, Canada

P1.87

Anti-inflammatory effect of low molecular weight heparin (LMWH) is mediated by placental high mobility group box 1 (HMGB1) modulation: New therapeutic perspectives for preeclampsia Cristian Zenerino1, Anna Maria Nuzzo1, Alessandra Zicari2, Domenica Giuffrida1, Tullia Todros1, Alessandro Rolfo1, 1Dept. of Surgical Sciences, University of Turin, Turin, Italy, 2Dept. of Experimental Medicine, University La Sapienza, Rome, Italy

P1.88

Hepcidin expression in placentae from preeclamptic pregnancies with or without fetal growth restriction. Anna Maria Nuzzo1, Alessandro Rolfo1, Simona Cardaropoli1, Ettore Piccoli1, Annalisa Piazzese1, Tullia Todros1, 1Dept. of Surgical Sciences, University of Turin, Turin, Italy

P1.89

Screening models for early detection of late-onset preeclampsia with various markers in low-risk pregnancy population Yeonkyung Cho1, Hee Jin Park1, Soo Hyun Kim1, Ji Yeon Kim1, Kyoung Jin Lee1, Dong Hyun Cha1, 1CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea

P1.90

2-methoxyestradiol regulates VEGFR-2 and sFlt-1 expression in human first trimester placental explants Dennis Lee1, Ori Nevo1,2, 1Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada, 2University of Toronto, Toronto, Ontario, Canada

P1.91

Development of a longitudinal pregnancy cohort and biospecimen repository to facilitate reproductive health research Amber L. Sexton1,2, Donald O. Chaffin1,2, Michael G. Gravett2,3, Craig E. Rubens1,3, 1Seattle Children's, Seattle, WA, USA, 2University of Washington, Seattle, WA, USA, 3Global Alliance to Prevent Prematurity & Stillbirth, Seattle, WA, USA

P1.92

The expressions of ECE-1 and NEP are regulated by TLR-4 signalling in gestational tissues Tomomi Kotani1, Yukio Mano1, Hiroyuki Tsuda1, Seiji Sumigama1, Eiko Yamamoto1, Hua Li2, Yuriko Watanabe1, Tomoko Nakano1, Fumitaka Kikkawa1, 1Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Bell Research Center for Reproductive Health and Center, Nagoya, Japan


P1.93

Phosphorylation changes in survival- and stress-response signalling pathways in the human placenta as an artefact of delayed tissue collection Hong wa Yung1, Francesca Colleoni1, Daniel Atkinson1, Emma Cook1, Stephen Charnock-Jones1, Graham Burton1, 1University of Cambridge, Cambridge, UK

P1.94

Acute fetal demise with early nonhuman primate pregnancy infection with Listeria monocytogenes Thaddeus Golos1, Gennadiy Bondarenko1, Maureen Durning1, Nancy Faith1, Heather Simmons1, Andres Mejia1, Charles Czuprynski1, 1University of Wisconsin-Madison, Madison, WI, USA

P1.95

Pyrosequencing of rhesus trophoblast mRNA reveals polymorphism and gene diversity of nonclassical MHC class I genes Anthony Desotell1, Mark Garthwaite1, Maureen Durning1, Patrick Bohn1, Thaddeus Golos1, 1University of Wisconsin-Madison, Madison, WI, USA

P1.96

Generation and testing of an ELISA that detects the newly discovered primate and placental specific sFlt variant (sFlt1-e15a) Kirsten Palmer1, Tu'uhevaha Kaitu'u-Lino1, Laura Touhey1, Louie Ye1, Alexis Shrub2, Stephen Tong1, 1Translational Obstetrics Group, Mercy Hospital, University of Melbourne, Victoria, Australia,

2Department of Obstetrics and Gynaecology, Mercy Hospital, University of Melbourne, Victoria, Australia

P1.97

Understanding the role of microRNAs during early cell lineage specification and stem cell maintenance Ursula Nosi1, Brian Cox1, 1University of Toronto, Toronto, Canada

P1.98

Differentiation of placental mesenchymal stromal cells into vascular endothelial cells Michael Litvack1, Andrea Tagliaferro2, Martin Post1, Isabella Caniggia2, 1The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada, 2Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada

P1.99

Nanoparticles can cross placenta and induce trophoblast apoptosis Chie-Pein Chen1,2, Yi-Yung Chen1, Chang-Ching Liu2, Pei-Chun Chen2, 1Division of High Risk Pregnancy, Mackay Memorial Hospital, Taipei, Taiwan, 2Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan

P1.100

Cellular model of placental iodide transport Huika Li1, Robin H Mortimer1,3, Kerry Richard1,3, 1Conjoint Endocrine Laboratory, Pathology Queensland, Health Services Support Agency, and the Department of Endocrinology and Diabetes, Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia, 2Institute of Health and Biomedical Innovation, the Queensland University of Technology, Brisbane, QLD, Australia, 3School of Medicine, The University of Queensland, Brisbane, QLD, Australia, 4Disciplines of Medicine, Obstetrics and Gynaecology, The University of Queensland, Brisbane, Australia

P1.101 Folate-mediated transport of nanoparticles for targeted drug delivery across BeWo cells Irina Kalashnikova1, Erik Rytting1, 1UTMB, Galveston, TX, USA

P1.102 SNAT2-specific transport function of betaine among amino acid transport system A subtypes Hiromi Eguchi1, Tomohiro Nishimura1, Mariko Usuda1, Sayaka Suda1, Masatoshi Tomi1, Emi Nakashima1, 1Keio University, Minato-ku, Tokyo, Japan

P1.103

Cytoprotective properties of hypotaurine by scavenging hydroxyl radicals in placental trophoblast cells Hikari Araki1, Duereh Mariam1, Tomohiro Nishimura1, Yuki Sugita1, Kei Higuchi1,2, Masatoshi Tomi1, Emi Nakashima1, 1Keio University, Minato-ku,Tokyo, Japan, 2Teikyo University, Itabashi-ku,Tokyo, Japan


P1.104

Mathematical models to predict exchange and facilitated transport across the microvillous plasma membrane (MVM) of the human placenta Kate Widdows1, Nuttanont Panitchob2, Ian Crocker1, Suzanne Brooks3, Colin Please3, Colin Sibley1, Ed Johnstone1, Bram Sengers2, Jo Glazier1, Rohan Lewis3, 1Maternal and Fetal Health Research Centre, University of Manchester, Manchester, UK, 2Bioengineering Research Group, University of Southampton, Southampton, UK, 3University of Southampton, Faculty of Medicine, Southampton, UK

P1.105

Fetal genotype influences spiral artery number and coiling in an angiotensinogen overexpressing mouse model Monique Y. Rennie1, Jessica Hebert2, Antonio Frias3, Xuemei Wu2, Kent L. Thornburg1, Terry K. Morgan2,3, 1Heart Research Center, Oregon Health and Science University, Portland, OR, USA, 2Department of Pathology, Oregon Health and Science University, Portland, OR, USA, 3Department of OB/GYN, Oregon Health and Science University, Portland, OR, USA

P1.106

High maternal BMI is associated with inhibition of placental PPARγ signaling and increased basal plasma membrane FATP2 expression Susanne Lager1, Francesca Gaccioli1, Vanessa I Ramirez1, Irving Aye1, Thomas Jansson1, Theresa L Powell1, 1Dept. of OB/GYN, University of Texas Health Science Center, San Antonio, Texas, USA

P1.107

Impact of human first trimester trophoblast cell line ACH-3P on the function of endothelial cells under different oxygen concentrations Gregor Weiss1, Ingrid Lang1, Monika Siwetz1, Berthold Huppertz1, Gerit Moser1, 1Medical University of Graz, Graz, Austria

P1.108

Placenteal hepatitis B virus infection and maternal liver function in HBsAg positive women Terence T Lao1, Man-Kin Chung1, Theresa KW Cheung1, Tat-San Lau1, Lai-Wa Law1, Vincent WS Wong1, Henry LY Chan1, Tak-Yeung Leung1, 1The Chinese University of Hong Kong, Hong Kong, Hong Kong

P1.109

Regulation of trophoblast syncytialization is mediated by the highly conserved zinc finger transcription factor OVO-like 1 Stephen J. Renaud1, M.A. Karim Rumi1, Michael J. Soares1, 1University of Kansas Medical Center, Kansas City, Kansas, USA

P1.110 ADAM12 localizes to invasive trophoblasts and promotes cellular invasion Mahroo Aghababaei1,2, Alexander G. Beristain1,2, 1University of British Columbia, Vancouver, British Columbia, Canada, 2Child and Family Research Institute, Vancouver, British Columbia, Canada

P1.111 Activin A, B and AB increase human trophoblast cell invasion by up-regulating N-cadherin Yan Li1, Jung-Chien Cheng1, Christian Klausen1, Peter Leung1, 1University of British Columbia, Vancouver, BC, Canada

P1.112 Transfection of BeWo cells with a truncated human endogenous retrovirus ERV3 env induces β-hCG Neal Rote1, Chuan Xu1, Huiqing Tan1, Sam Mesiano1, 1University Hospitals Case Medical Center, Cleveland, OH, USA

P1.113 Placental perfusion as a model of synctiotrophoblast vesicle release Dionne Tannetta1, Rebecca Dragovic1, Chris Redman1, Ian Sargent1, 1University of Oxford, Oxford, UK

P1.114

Generation of cytotrophoblast-like cells from human embryonic stem cells in defined media Yingchun Li1, Francesca Soncin1, Matteo Moretto-Zita1, Anna Wakeland1, Louise Laurent1, Mana Parast1, 1University of California San Diego, La Jolla, USA


P1.115 MiR-21 regulates proliferation and invasion in trophoblastic cells and targets PTEN Wittaya Chaiwangyen1, Diana Morales-Prieto1, Stephanie Ospina-Prieto1, Ekkehard Schleussner1, Udo Markert1, 1Placenta-Labor, Department of Obstetrics, University Hospital Jena, Jena, Germany

P1.116 Kruppel-like factor-6 activates peroxisome proliferator activated receptor and promotes trophoblast differentiation in BeWo cell lines Georges Daoud1, Zeinab Boussi1, Rebecca Assaf1, 1American University of Beirut, Beirut, Lebanon

P1.117

The gap junction channel encoding genes connexin31 (Gjb3) and connexin31.1 (Gjb5) have directly opposed effects on trophoblast stem cell differentiation during mouse placental development Mark Kibschull1, Keith Colaco1, Elzbieta Matysiak-Zablocki1, Elke Winterhager2, Stephen Lye1,3, 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, 2University of Duisburg-Essen, Medical School, Essen, Germany, 3University of Toronto, Dept. of Obstetrics and Gynecology, Physiology and Medicine, Toronto, Ontario, Canada

P1.118 LIF stimulation of HTR8/SV-neo cell-derived spheroids reduces stemness-related factors Stella Mary Photini1, Justine S Fitzgerald1, Ekkehard Schleussner1, Udo R. Markert1, 1Placenta Lab, Jena, Germany

P1.119

The involvement of the transcription factor Nrf2 in the vascular homeostasis of the placenta Nisreen Kweider1, Christoph Jan Wruck1, Berthold Huppertz2, Mamed Kadyrov1,4, Jenny Kistermann1, Thomas Pufe1, Werner Rath4, 1Department of Anatomy and Cell Biology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 2Institute of Cell Biology, Histology & Embryology, Medical University of Graz, Graz, Austria, 3MEDIAN Kliniken, Baden-Wuerttemberg, Germany, 4Department of Obstetrics and Gynecology, University Hospital of the RWTH, Aachen, Germany

P1.120 Placental DNA methylation pattern in preeclampsia Keiko Koide1, Kyoko Hori1, Satoshi Miyagami1, Shin Takenaka1, Akihiro Kawashima1, Hiroshi Chiba1, Akihiko Sekizawa1, 1Showa University School of Medicine, Tokyo, Japan

P1.121

Preliminary study on the relation between the expression of TLR-2 in placenta tissue and HBV intrauterine infection Jinghua Liu1, Xiaohong Zhang1, Ying Lin1, 1Public Health Clinical Center Affiliated to Fudan University, ShangHai, China

P1.123

Associations between cholesterol blood levels, placental lipid content and expression of cholesterol transporters in healthy and diseased placentas Meike Körner3, Marc Baumann4,2, Xiao Huang1,2, Daniel Surbek4,2, Christiane Albrecht1,2, 1Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland, 2Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, Bern, Switzerland, 3Institute of Pathology, University of Bern, Bern, Switzerland, 4Department of Obstetrics and Gynecology, University Hospital, University of Bern, Bern, Switzerland

P1.124

First trimester maternal circulating levels of pregnancy-associated plasma protein A2 (PAPP-A2) are elevated in pregnancies that subsequently develop preeclampsia Erin Crosley1, Ursula Durland2, Ken Seethram2, Scott MacRae3, Andrée Gruslin4, Julian Christians1, 1Simon Fraser University, Burnaby, British Columbia, Canada, 2Pacific Centre for Reproductive Medicine, Burnaby, British Columbia, Canada, 3Provincial Health Services Authority, Vancouver, British Columbia, Canada,

4Ottawa Hospital Research Institute, Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada


P1.125

Characterization of DUFFY decoy deceptor in placentae from pregnancies complicated by both preeclampsia and gestational diabetes Domenica Giuffrida1, Alessandro Rolfo1, Anna Maria Nuzzo1, Cristian Zenerino1, Tullia Todros1, 1Dept. of Surgical Sciences, University of Turin, Turin, Italy

P1.126

A model at 15 weeks' gestation to discriminate between uncomplicated pregnancies and those destined to develop preeclampsia Shalem Leemaqz1, Gus Dekker1, Lesley McCowan2, Claire Roberts1, 1University of Adelaide, Adelaide, Australia, 2University of Auckland, Auckland, New Zealand

P1.127

Differential effects of heparin on preeclampsia patients – subclassification of preeclampsia Jodie Odame1, John Kingdom2,1, Brian Cox1, 1University of Toronto, Toronto, ON, Canada, 2Mount Sinai Hospital, Toronto, ON, Canada

P1.128

Placental STOX1 Y153H mutation is associated with severe early onset Preeclampsia and low birth weight Caroline Dunk1, Marie Van Djik2, Laura Anderson1, Cees Oudejans2, Stephen J Lye1,3, 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, 2Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands, 3Departments of Obstetrics and Gynecology and Physiology, The University of Toronto, Toronto, ON, Canada

P1.129

Assessment of cardiac parameters in large for gestational age infants in mothers with & without gestational diabetes: Correlation with placental pathology P. Charlagorla1, H. Inany1, M. Gudavalli1, M. Chhabra1, C. Salafia1, B. Dygulska1, P. Narula1, A. Gad1, 1New York Methodist Hospital, Brooklyn/NY, USA

P1.130

Development of online teaching modules for understanding placenta pathology David Grynspan1, Benoit Desrochers1, Andree Gruslin2,3, Laura McDonell1, Julien Yockell-Lelievre2, Christopher Ball3, Nasser Al-Abbad2,3, 1Childrens Hospital of Eastern Ontario, Ontario, Canada, 2The Ottawa Hospital, Ontario, Canada, 3The University of Ottawa, Ontario, Canada

P1.131

Comparison of genome-wide and gene-specific DNA methylation between pregnancies conceived naturally versus ART (Assisted Reproductive Technologies) Nir Melamed1, Sanaa Choufani1, Louise Wilkins-Haug2, Ellen Greenblatt3, Rosanna Weksberg1, 1Hospital for Sick Children, Toronto, ON, Canada, 2Brigham and Women's Hospital, Boston, MA, USA, 3Mount Sinai Hospital, Toronto, ON, Canada

P1.132

The effect of maternal habitus on the placental growth in triplet pregnancies Eun Na Kim1,3, Chong Jai Kim1,3, Jong Kwan Jun2, 1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, 2Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea, 3The Pregnancy Research Group (PREG), Seoul, Republic of Korea

P1.133

Fetal and placental hypoxia programs long-term endothelial dysfunction and hypertension: role of endothelin-1 Stephane Bourque1, Christian Rueda-Clausen1, Sandra Davidge1, 1University of Alberta, Edmonton, Alberta, Canada

P1.134

Effect of advanced maternal age on pregnancy outcome in the rat Alison Care1, Jude Morton1, Sandra Davidge1, 1University of Alberta, Edmonton, AB, Canada


Appendix D - Poster Session 2

P2.1

Placental dysmaturity underlies the superimposed chronic hypoxic change in stillbirths from diabetic mothers WEI LIU1, Pooja Agarwal2, Jerzy Stanek2, 1Department of Pathology and Laboratory medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA, 2Division of Pathology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA

P2.2

Histological study of the mid-gestational murine placenta with emphasis on its hematopoietic potential Nathália Azevedo Portilho1, Priscila Tavares Guedes1, Marcelo Pelajo-Machado1, 1Laboratory of Pathology - Instituto Oswaldo Cruz/ Fiocruz, Rio de Janeiro/ RJ, Brazil

P2.3

Differences in neonatal outcomes according to the stage of acute chorioamnionitis and funisitis in preterm premature rupture of membranes Hyun-joo Kim1, Yeri Lee1, Suk-Joo Choi1, Soo-young Oh1, Jung-Sun Kim2, Cheong-Rae Roh1, Jong-Hwa Kim1, 1Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

P2.4

Evaluating the significance of placental findings seen in stillbirth: a systematic review Imogen Ptacek1,2, Paul Brownbill1,2, Alexander Heazell1,2, 1Maternal and Fetal Health Research Centre, Manchester, UK, 2University of Manchester, Manchester, UK

P2.5

Duration and method of tissue storage alters placental morphology – Implications for clinical and research practice Ainslie Garrod1, Gauri Batra2, Imogen Ptacek1, Alexander Heazell1, 1Maternal and Fetal Health Research Centre, Manchester, UK, 2Department of Paediatric Histopathology, Manchester, UK

P2.6

KIR-like LY49 receptors: Insights into pregnancy complications linked to inhibition of uterine Natural Killer cell functions Patricia Lima1, Mir Munir Rahim2, Megan Tu2, Annie Peng1, B Anne Croy1, Andrew Makrigiannis2, 1Queen's University, Kingston, Canada, 2University of Ottawa, Ottawa, Canada

P2.7

Gestational modification of murine spiral arteries does not reduce their drug-induced vasoconstrictive responses in situ Sean Leonard1, B. Anne Croy2, Coral L. Murrant1, 1University of Guelph, Guelph, ON, Canada, 2Queen's University, Kingston, ON, Canada

P2.8

Chorioallantoic placentation in viperid snakes Selma Almeida-Santos1,2, Maria Angélica Miglino1, 1Departamento de Cirurgia/Anatomia –FMVZ-USP Universidade de São Paulo, São Paulo, SP, Brazil, 2Laboratório de Ecologia e Evolução, Instituto Butantan, São Paulo, SP, Brazil

P2.9

TGFβ-mediated polarization of decidual neutrophils Melissa Kwan1,2, Caroline Dunk1, Stephen Lye1,2, 1Samuel Lunenfeld Research Institute, Toronto, Canada,

2Department of Physiology, University of Toronto, Toronto, Canada

P2.10

Dynamic Contrast Enhanced MRI in the nonhuman primate allows correlation of in vivo placental perfusion with in vitro placental outcomes Victoria Roberts2, Jessica Walker2, Christopher Kroenke1,2, Matthias Schabel1, Jamie Lo1, Karen Oh1, Kevin Grove2, Antonio Frias1, 1Oregon Health and Science University, Portland, OR, USA, 2Oregon National Primate Research Center, Beaverton, OR, USA


P2.11

Metabolic scaling law for mouse fetal and placental weight Malgorzata Gasperowicz1, Michael Yampolsky2, Carolyn Salafia3, James Cross1, 1University of Calgary, Calgary, Alberta, Canada, 2University of Toronto, Toronto, Ontario, Canada, 3Placental Analytics, Larchmont, NY, USA

P2.12

Macroscopic and microscopic placental development in the South American Coati Nasua nasua (Mammalia, Carnivora, Procyonidae) João Carlos Morini Jr.1, Adriana C. Morini2, Phelipe O. Favaron1, Natalia J. Gonçalves1,3, M. Angelica Miglino1, Andrea Mess1, Carlos E. Ambrósio1,3, 1Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, SP, Brazil, 2Federal University of West Para, IBEF: Institute of Biodiversity and Florest, Santarém, Pará, Brazil, 3Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, Pirassununga, SP, Brazil

P2.13

The feline amniotic membrane: a valuable alternative source of mesenchymal stem cells Atanasio S. Vidade1, Aline F. Souza1, Juliano R. Sangali1, Rafael Sampaio1, Fabiana F Bressan1, Juliana B Casals1, Naira C. Pierre1, Celina A Mançanares1, Flavio Meirelles1, M. Angelica Miglino1, Daniele S Martins1, Carlos E. Ambrósio1, 1Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, Pirassununga, SP, Brazil

P2.14

Canine iPSC generation with non-integrative vectors Natalia J. Gonçalves1, Sehwon Koh2, Fabiana F. Bressan1, Daniele S. Martins1, Flávio V. Meirelles1, Jorge Piedrahyta2, Carlos E. Ambrósio1, 1Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, Pirassununga, SP, Brazil, 2Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA

P2.15

Placental evolution in the anteaters and armadillos (Eutheria, Xenarthra) Andrea Mess1, Phelipe Favaron1, Christiane Pfarrer2, Maria Angelica Miglino1, 1Department of Surgery, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil,

2Institute of Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany

P2.16

Placental development in Necromys lasiurus (Rodentia, Cricetidae) - functional morphology using stereological approach Phelipe Favaron1, Andrea Mess1, Moacir de Oliveira2, Maria Angelica Miglino1, Pascale Chavatte-Palmer3,4, Anne Tarrade3,4, 1Department of Surgery, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil, 2Department of Animal Science, Universidade Federal Rural do Semi-Árido, Mossoró, Rio Grande do Norte, Brazil, 3INRA, UMR 1198 Biologie du Développement et Reproduction, Jouy-en-Josas, Paris, France, 4ENVA, Maisons-Alfort F-94704, Maisons-Alfort, Paris, France

P2.17

Roles of HtrA1 and HtrA3 in the development of mouse placenta Md. Zobaer Hasan1, Chio Oka1, Masashi Kawaichi1, 1Nara Institute of Science & Technology, Ikoma, Japan

P2.18

The role of ovarian and fetal factors on placental growth in late gestation in mice Sarah Isaac1,2, Dawei Qu1, S. Lee Adamson1,2, 1Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada, 2Departments of Physiology, and Obstetrics and Gynaecology, University of Toronto, Toronto, Canada

P2.19

Influence of high fat diet sensitivity and resveratrol supplementation on placental fatty acid uptake in the Japanese macaque Perrie O'Tierney-Ginn1, Victoria Roberts3, Kent Thornburg2, Kevin Grove3,2, Antonio Frias2,3, 1MetroHealth Medical Center, Cleveland, OH, USA, 2Oregon Health & Science U, Portland, OR, USA, 3Oregon National Primate Research Center, Beaverton, OR, USA


P2.20

Association of the miR-371-3 cluster and trophoblast migration Tanja Groten1, Michael Schoenleben1, Diana Morales-Prieto1, Ekkehard Schleussner1, Udo Markert1, 1University Hospital Jena, Deparment of Obstetrics Placentalabor, Jena, Germany

P2.21

Analysis of placental vascularization in a pharmacological rabbit model of IUGR induced by L-NAME, a nitric oxide synthase inhibitor Anne Tarrade1,2, Edouard Lecarpentier1,3, Sophie Gil2,3, Olivier Morel1,4, Noël Zahr5, Michèle Dahirel1,2, Vassili Tsatsaris3,6, Pascale Chavatte-Palmer1,2, 1INRA, UMR 1198 Biologie du Développement et Reproduction, Jouy-en-Josas, France, 2Fondation PremUp, Paris, France, 3INSERM U767, Université Paris-Descartes, Paris, France, 4Département d’obstétrique et de gynécologie, Maternité régionale Universitaire de Nancy, Université Nancy I H.Poincaré, Nancy, France, 5UF pharmacologie et pharmacogénétique, Groupe hospitalier Pitié-Salpêtrière, Paris, France, 6Unité d’obstétrique et de gynécologie, Maternité Port-Royal, APHP, Université Paris V, Paris, France

P2.22

MHC-independent receptors contribute to uterine natural killer cell activation and function during mouse pregnancy Allison Felker1, Patricia Lima1, Zhilin Chen1, Warren Foster2, Anne Croy1, 1Queen's University, Kingston, Ontario, Canada, 2McMaster University, Hamilton, Ontario, Canada

P2.23

Relaxation of human placental chorionic plate blood vessels by calcium-activated potassium channel activation Felicity Hey1, Christina E Hayward1, Mark Wareing1, 1The University of Manchester, Manchester, UK

P2.24

Elevated shear stress in fetal growth restriction results in a sustained increase in endothelial expression and activation of eNOS and iNOS in the fetoplacental vasculature Sarah Jones1, Helen Bischof1, Edward Johnstone1, Ingrid Lang2, Gernot Desoye2, Sue Greenwood1, Mark Wareing1, Colin Sibley1, Paul Brownbill1, 1University of Manchester, Manchester, UK, 2Medical University of Graz, Graz, Austria

P2.25

Fetal inflow hydrostatic pressure measurements in the ex-vivo perfused placenta correlate with umbilical artery Doppler RI and PI values Sarah Jones1, Helen Bischof1, Edward Johnstone1, Sue Greenwood1, Mark Wareing1, Colin Sibley1, Paul Brownbill1, 1University of Manchester, Manchester, UK

P2.26

Do decidual natural killer cells have a role in vascular smooth muscle cell dedifferentiation during spiral artery remodelling? Amanda Host1, Alison Wallace1, Guy Whitley1, Judith Cartwright1, 1St. George's, University of London, London, UK

P2.27

Human cytomegalovirus (HCMV) infection requires S1P to increase endothelial permeability Daniel Kerage1, Maggie Wang1, Shreya Amin1, Randi Gombos1, Denise G. Hemmings1, 1University of Alberta, Edmonton, Alberta, Canada

P2.28

Genome-wide epigenetic study in monochorionic(MC) twins after fetoscopic laser photocoagulation(FLP) at birth TAIZAN KAMIDE1, YUKI ITO1, NAGAYOSHI UMEHARA1, MARI MITUI1, KENTARO MATUOKA1, HARUHIKO SAGO1, KENICHIRO HATA1, 1National Center for Child Health and Development, Tokyo, Japan

P2.29

Random allelic bias of an X-linked gene in human full-term placenta? Joana Carvalho Moreira de Mello1, Fernado Galati Sabio1, Lygia da Veiga Pereira1, 1IB-USP, Sao Paulo, Brazil


P2.30

Quantification of DNA methylation at imprinted domains in the placenta Maria Peñaherrera1,2, Magda Price1,3, John Blair1,2, Margot Van Allen2, Deborah McFadden2,4, Wendy Robinson1,2, 1Child & Family Research Institute, Vancouver, BC, Canada, 2Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada, 3Department of Obstetrics and Gynaecology, Children's & Women's Health Centre of British Columbia, Vancouver, BC, Canada, 4Department of Pathology and Laboratory Medicine, Children's & Women's Hospitals of British Columbia, Vancouver, BC, Canada

P2.31

Epigenetic profiling of pre-eclamptic placentas Hester Roberts1,2, Erin Macaulay1,2, Noelyn Hung1,2, Ian Morison1,2, 1University Of Otago, Dunedin, New Zealand, 2Gravida: National Centre for Growth and Development, Auckland, New Zealand

P2.32

SIRT1: Identification of a novel placental stress-response protein that regulates fetal growth? Sanjana Sivasalapathi1, Jeremiah Gaudet3, Annabelle Caron2,3, Michael McBurney2,3, Shannon Bainbrige1,3, 1Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada, 2Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, 3Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada

P2.33

The functional effect of Syndecan1 deficiency in BeWo cells and its implications in fetal growth restriction. Tilini Gunatillake1,2, Amy Chui1, Padma Murthi2, Vera Ignjatovic3,4, Paul Monagle3,4, John Whitelock5, Shaun Brennecke2, Joanne Said1, 1Department of Medicine, The University of Melbourne, St Albans, Victoria, Australia, 2Departmenf of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia, 3Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia, 4Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia, 5Graduate School of Biomedical Engineering, The University of New South Wales, Kensington, New South Wales, Australia

P2.35

Decreased VDR expression contributes to reduced feto-placental growth in idiopathic human fetal growth restriction. Tejasvy Cholangi1, Hannah Yong1, Thy Nguyen1, Anthony Borg1, Shaun Brennecke1, Padma Murthi1, 1Department of Perinatal Medicine Pregnancy Research Centre and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women’s Hospital, Melbourne, Victoria, Australia

P2.36

Phlda2 - an imprinted growth restricting gene that drives metabolic programming Simon Tunster1, Mathew Van de Pette1, Ben Tycko2, Rosalind John1, 1Cardiff University, Cardiff, Wales, UK,

2Columbia University, New York, USA

P2.37

Abnormal maternal inflammation in the rat is associated with placental HIF-1a accumulation and nitrosative stress Arissa Sperou1, Tiziana Cotechini1, Shannyn K. MacDonald-Goodfellow1, Charles H. Graham1, 1Queen's University, Kingston, ON, Canada

P2.38

Relationship between placental location and intrauterine fetal growth DONG WOOK KWAK1, YONG WON PARK2, YOUNG HAN KIM2, 1Cheil General Hospital, Seoul, Republic of Korea, 2Yonsei University Health System, Seoul, Republic of Korea

P2.39

Decidual natural killer cells regulate FUT4 expression in EVT through DNA enhancer methylation Yuxiang Hu1, John Blair1, Ryan Yuen2, Wendy Robinson1, Peter von Dadelszen1, 1Child and Family Research Institute, Vancouver, Canada, 2The Hospital for Sick Children, Toronto, Canada


P2.40

Gene expression analysis of the microdissected trophoblast layer of human placenta after the spontaneous onset of labor Soo Hyun Kim1, Sung Han Shim1, Se Ra Sung1, Kyoung Jin Lee1, Dong Hyun Cha1, Jung Yun Shim1, Kyung A Lee2, 1CHA Gangnam Medical Center, CHA university, Seoul, Republic of Korea, 2College of Life Science, CHA University, Seoul, Republic of Korea

P2.41

Targeted gene analysis in preeclampsia Frank Louwen1, Cornelia Muschol-Steinmetz1, Joscha Reinhard2, Alexandra Friemel1, Juping Yuan1, 1Department of Gynecology and Obstetrics, School of Medicine, J. W. Goethe-University, Frankfurt, Germany, 22Department of Gynecology and Obstetrics, St. Marien Hospital, Frankfurt, Germany

P2.42

The human placental sexome differs between trophoblast epithelium and villous vessel endothelium Silvija Cvitic1, Mark S. Longtine2, Hubert Hackl3, Karin Wagner1, Michael D. Nelson2, Luciana Lassance Gomes1, Gernot Desoye1, Ursula Hiden1, 1Medical University of Graz, Graz, Austria, 2Washington University, St. Louis, MO, USA, 3Medical University of Innsbruck, Innsbruck, Austria

P2.43

Genomic approaches for the identification of genes and enhancers regulating placenta development Geetu Tuteja1, Aaron Wenger1, Karen Betancourt Moreira1, Tisha Chung1, Gill Bejerano1, 1Stanford University, Stanford, CA, USA

P2.44

Combination methotrexate and gefitinib (EGFR inhibitor) as a novel therapeutic to medically treat ectopic pregnancies: preclinical studies and human trials Monika Skubisz1,2, Andrew Horne3, Ulrika Nilsson1,2, Terrence Johns4, Tu'uhevaha Kaitu'u-Lino1, Tania Wilmann2, W.Colin Duncan3, Hilary Critchley3, Euan Wallace2, Stephen Tong1, 1Translational Obstetrics Group, Mercy Hospital, University of Melbourne, Victoria, Australia, 2The Ritchie Centre, Monash Institute of Medical Research, Monash University, Victoria, Australia, 3MRC Centre for Reproductive Medicine, University of Edinburgh, Edinburgh, UK, 4Centre for Cancer Research, Monash Institute of Medical Research, Victoria, Australia

P2.45

The effect of TGFβ on extravillous trophoblast outgrowth during the first trimester of pregnancy Jennifer Prossler1, Larry Chamley1, Jo James1, 1University of Auckland, Auckland, New Zealand

P2.46

Decidual stromal cell interactions with trophoblast are not altered in pregnancies with impaired spiral artery remodelling Alison Wallace1, Brooke Lumicisi1, Alexandra Armstrong1, Judith Cartwright1, Guy Whitley1, 1St George's, University of London, London, UK

P2.47

Serotonin production by human and mouse trophoblast: Involvement in placental development and function Kathy Deroy1,2, Francine Côté2, Thierry Fournier3,2, Thomas Sanderson1,2, Cathy Vaillancourt1, 1INRS-Institut Armand Frappier, Laval, Quebec, Canada, 2Université Paris Descartes, Centre National de la Recherche Scientifique - Unité Mixte de Recherche 8147, Hopital Necker, Paris, France, 3Université Paris Descartes, Sorbonne and PremUP, Paris, France

P2.48

JMJD6 - a novel oxygen sensor in the human placenta Sruthi Alahari1,2, Isabella Caniggia1,2, 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, 2Department of Obstetrics and Gynaecology & Physiology, University of Toronto, Toronto, Ontario, Canada

P2.49

Dynamic role of SUMOylation in regulating HIF-1α stability and activity in human placenta Jayonta Bhattacharjee1, Isabella Caniggia1,2, 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, 2Department of Obstetrics & Gynaecology and Physiology, University of Toronto, Toronto, Ontario, Canada


P2.51

Chorionic vascular structure and placental functional efficiency (beta) differ in high and low autism risk placental cohorts Carolyn Salafia1,2, Theresa Girardi1,2, Michael Yampolsky1,3, Oleksandr Shlakhter3,4, Craig Newschaffer5, Danielle Fallin6, Cheryl Walker7, CJ Stodgell8,9, PJ Katzman8,9, J Culhane8,10, P Landrigan8,11, S Szabo8,12, N Thieux8,13, J Swanson8,14, N Dole8,15, MW Varner8,16, John Moye8,17, Richard Miller8,9, 1Placental Analytics LLC, Larchmont, NY, USA, 2Institute for Basic Research, Staten Island, NY, USA, 3University of Toronto, Toronto, Ontario, Canada, 4Alberta Health Services, Edmonton, Alberta, Canada, 5Drexel University, Philadelphia PA, USA, 6Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, 7University of California, Davis, Davis, CA, USA, 8National Children's Study Placenta Consortium, Bethesda MD, USA, 9University of Rochester School of Medicine and Dentistry, Rochester NY, USA, 10The Children’s Hospital of Philadelphia, Philadelphia PA, USA, 11Mount Sinai School of Medicine, New York, NY, USA, 12Medical College of Wisconsin, Milwaukee, WI, USA, 13South Dakota State University, Brookings, SD, USA, 14University of California at Irvine, Irvine, CA, USA, 15University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 16University of Utah, Salt Lake City, UT, USA, 17NIH/National Children’s Study, Bethesda MD, USA

P2.52

Vessel enhancement with multiscale and curvilinear filter matching for placenta images Jen-Mei Chang1, Nen Huynh1, Marilyn Vasquez1, Carolyn Salafia2,3, Barbara Eucker4, John Thorp4, Sandhya Mittal2,3, 1California State University, Long Beach, Long Beach, CA, USA, 2Placental Analytics LLC, Larchmont, NY, USA, 3Institute for Basic Research, Staten Island, NY, USA, 4University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

P2.53

Mapping placental topology from 3D scans, the graphic display of variation in arborisation across gestation Carolyn Salafia1,2, Michael Yampolsky3, Denis Vulk4, CJ Stodgell5,6, PJ Katzman5,6, J Culhane5,7, P Landrigan5,8, S Szabo5,9, N Thieux5,10, J Swanson5,11, N Dole5,12, MW Varner5,13, John Moye5,14, Richard Miller5,6, 1Placental Analytics LLC, Larchmont, NY, USA, 2Institute for Basic Research, Staten Island, NY, USA, 3University of Toronto, Toronto, Ontario, Canada, 4Kungliga Tekniska Hogskolan ( (Royal Institute of Technology), Stockholm, Sweden, 5National Children's Study Placenta Consortium, Bethesda MD, USA, 6University of Rochester School of Medicine and Dentistry, Rochester NY, USA, 7The Children’s Hospital of Philadelphia, Philadelphia PA, USA, 8Mount Sinai School of Medicine, New York, NY, USA, 9Medical College of Wisconsin, Milwaukee, WI, USA, 10South Dakota State University, Brookings, SD, USA, 11University of California at Irvine, Irvine, CA, USA, 12University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 13University of Utah, Salt Lake City, UT, USA, 14NIH/National Children’s Study, Bethesda MD, USA

P2.54

Developmental alterations in bovines derived from reproductive techniques Myrian Alberto1, Flávio Meirelles2, Felipe Perecin2, Phelipe Favaron1, Andrea Mess1, Maria Angelica Miglino1, 1Department of Surgery, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil, 2Faculty of Animal Sciences and Food Engineering, University of Sao Paulo, Pirassununga, Sao Paulo, Brazil

P2.55

The placental expression of Human Leukocyte Antigen HLA-F and HLA-E in early normal placentation Rinat Hackmon1,2, Lakmini Pinnaduwage3, John Kingdom1,4, Gideon Koren2, Dan Geraghty5, Stephen Lye1,4, Caroline Dunk4, 1University of Toronto Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto/ON, Canada, 2University of Toronto Department of Clinical Pharmacolgy, Sick Kids Hospital, Toronto/ON, Canada, 3University of Toronto Department of Physiology, Toronto/ON, Canada, 4Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto/ON, Canada, 5Fred Hutchinson Cancer Research Institute, Clinical Division, Seattle/WA, USA


P2.56

Cytokine profile of CD4+ T-cells in decidua and circulation in 3rd trimester pregnancy Guro Mørk Johnsen1,3, Kjetil Taskén2,3, Anne Cathrine Staff1,4, 1Department of Obstetrics and Department of Gynaecology, Oslo University Hospital Ulleval, Oslo, Norway, 2NCMM - Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, Oslo, Norway, 3The Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway, 4Faculty of Medicine, University of Oslo, Oslo, Norway

P2.57

Decidual natural killer cell receptor expression is altered in pregnancies with impaired spiral artery remodelling Alison Wallace1, Amanda Host1, Guy Whitley1, Judith Cartwright1, 1St George's, University of London, London, UK

P2.58

A role for shared placenta/tumor antigen specific T cells in altering the risk of cancer in parous mothers Susmita Jasti1, Vargheese Chennathukuzhi1, Thomas Yankee1, Brian Petroff1, Margaret Petroff1, 1The University of Kansas Medical Center, Kansas City, KS, USA

P2.59

Disengagement of activating receptor and function of second trimester decidual natural killer cells Jianhong Zhang1, Caroline E Dunk1, Setephen J Lye1,2, 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, 2Department of Physiology/Obstetrics and Gynecology, University of Toronto, Toronto, Canada

P2.60

A comparison of 2D and 3D estimates of placental volume in early pregnancy Christina Aye2, Gordon Stevenson3, Lawrence Impey2, Sally Collins1,2, 1Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK, 2Fetal Medicine Unit, John Radcliffe Hospital, Oxford, UK,

3Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK

P2.61

GNRH induces trophoblast invasion and capillary-like network formation via RUN-X2-mediated trophoblast invasion and capillary-like network formation via RUNX2-mediated MMP2/9 expression BO PENG1, HUA ZHU1, CHRISTIAN KLAUSEN1, PETER C.K. LEUNG1, 1Child & Family Research Institute, British Columbia, Canada

P2.62

Placental Hepatitis B virus infection and fetal acid-base balance in HBsAg positive women Lai-Wa Law1, Terence T Lao1, Man-Kin Chung1, Theresa KW Cheung1, Tat-San Lau1, Vincent WS Wong1, Henry LY Chan1, Tak-Yeung Leung1, 1The Chinese University of Hong Kong, Hong Kong, Hong Kong

P2.63

Effects of placental HBV infection on the Parkinson 7 gene expression Man-Kin Chung1, Tat-San Lao1, Russell YT Ng1, Theresa KW Cheung1, Vincent WS Wong1, Henry LY Chan1, Tak-Yeung Leung1, Terence T Lao1, 1The Chinese University of Hong Kong, Hong Kong, Hong Kong

P2.64

Trypanosoma cruzi induces differentiation of the trophoblast Christian Castillo1, Ana Liempi1, Daniel Droguett1, Juan Duaso1, Mauricio Cerda1, Stefen Härtel1, Norbel Galanti1, Juan Diego Maya1, Ulrike Kemmerling1, 1Institute for Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile

P2.65

Trypanosoma cruzi induces cellular proliferation in the trophoblastic cell line BeWo Daniel Droguett1,2, Ana Liempi1, Christian Castillo1, Juan Duaso1, Mauricio Cerda1, Stefen Härtel1, Norbel Galanti1, Juan Diego Maya1, Ulrike Kemmerling1, 1Institute for Biomedical Sciences, Faculty of Medicine; University of Chile, Santiago, Chile, 2Facultad Ciencias de la Salud, Universidad de Talca, Talca, Chile


P2.66

Distribution and immunophenotype of macrophages in the chorioamniotic membranes of chronic chorioamnionitis versus acute chorioamnionitis Jung-Sun Kim1,2, Ja Yun Jang2, Ha Young Park1, Yi Seul Kim2, Cheong-Rae Roh3, Soo-Young Oh3, Suk-Joo Choi3, 1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 2Department of Health Sciences of Technology, Sungkyunkwan University, SAIHST, Seoul, Republic of Korea, 3Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

P2.67

Inflammatory transcriptional control of microRNA expression in term human decidual cells William Ackerman1, Sherrine Ibrahim1, Taryn Summerfield1, Joseph Huang1, Charles Lockwood1, Douglas Kniss1, 1The Ohio State University, Columbus, OH, USA

P2.68

Inflammation as a cause of placental dysfunction in high-risk pregnancies Sylvie Girard1,2, Alexander Heazell1, Colin Sibley1, Stuart Allan2, Rebecca Jones1, 1Maternal and Fetal Health Research Centre, University of Manchester, Manchester, UK, 2Faculty of Life Sciences, University of Manchester, Manchester, UK

P2.69

Placental cell-derived exosomes increase in maternal circulation with gestational age Carlos Salomon1, Maria Jose Torres2, Sebastián Illanes2, Miharu Kobayashi1, Luis Sobrevia3, Keith Ashman1, Murray Mitchell1, Greg Rice1, 1University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia, 2Department of obstetric and Gynecology, Universidad de los Andes, Santiago, Metropolitana, Chile, 3Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Metropolitana, Chile

P2.70

Hypoxia-induced changes in the bioactive Of cytotrophoblast-derived exosomes Carlos Salomon1, Miharu Kobayashi1, Murray Mitchell1, Greg Rice1, 1University of Queensland Centre for Clinical Research, Brisbane/Queensland, Australia

P2.71

Placental key enzymes of the endocannabinoid system in maternal obesity (MO): from primate to primate Zorica Janjetovic1, Sonali Gupta1, Iram Rodríguez-Sánchez2, Jaques Samson1, Brian Brocato1, Mauro Schenone1, Danielle Tate1, Norman Meyer1, Andrzej Slominski1, Bob Moore1, Giancarlo Mari1, Natalia Schlabritz-Loutsevitch1, 1University of Tennessee Health Science Center, Memphis, TN, USA, 2Universidad Autónoma de Nuevo León, Monterrey, Mexico

P2.72

How a male fetus adapts to maternal obesity (MO)? Sonali Gupta1, Jacques Samson1, Mauro Schenone1, Brian Brocato1, Danielle Tate1, Norman Meyer1, Giancarlo Mari1, Natalia Schlabritz-Loutsevitch1, 1University of Tennessee Health Science Center, Memphis, USA

P2.73

Changes in growth pattern during gestation in the endothelio-chorial placenta in mink (Mustela vison) Vibeke Dantzer1, Henrik Winther3, Jan -D Haeger2, Christiane Pfarrer2, 1Copenhagen University, DK 1870 Frederiksberg C, Denmark, 2, University of Veterinary Medicine, Hannover, 30173, Germany, 3, Dako A/S, Produktionsvej 42, DK-2600 Glostrup, Denmark

P2.74

Vitamin C transporters in the guinea pig placenta Astrid B Kjærgaard1, Janne G Schjoldager1, Pernille Tveden-Nyborg1, Jens Lykkesfeldt1, Vibeke Dantzer1, 1Copenhagen University, Frederiksberg C Copenhagen, Denmark


P2.75

The effect of nutritional supplementation during pregnancy on placental transporter expression in placentas from Gambian women Modou Lamin Jobarteh1,2, Sophie Moore2, Christine Kennedy1, Lorraine Gambling1, Harry J McArdle1, 1Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK, 2MRC International Nutrition Group, MRC Keneba, MRC Unit The Gambia, Banjul, Gambia

P2.76

Effects of folic acid supplementation on placental health and function Tasfia Ahmed1, Ilan Fellus1, Bénédicte Fontaine-Bisson1, Shannon Bainbridge0, 1University of Ottawa, Ottawa, Ontario, Canada

P2.77

Novel investigation of the importance of Ste20-like kinase, SLK, in murine placentation Prabhjot Sekhon1,2, Khalid Al-Zahrani1,2, Daniel Tessier1, Julien Yockell-Lelièvre1, Luc A. Sabourin1, Andrée Gruslin1,3, 1Ottawa Hospital Research Institute, Ottawa, Canada, 2University of Ottawa, Ottawa, Canada,

3The Ottawa Hospital, Ottawa, Canada

P2.78

Development of novel nanocarriers displaying tumour homing peptides for targeted delivery of drugs to the placenta Anna King1, Francesco Cellesi1, John Aplin1, Lynda Harris1, 1University of Manchester, Manchester, UK

P2.79

Thrombin activation of maternal platelets causes placental developmental failure through a mechanism independent of thrombosis in a murine high-risk pregnancy model Vidhyalakshmi Arumugam1, Jianzhong An1, Michelle Bordas1, Rashmi Sood1, 1Medical College of Wisconsin, Milwaukee, WI, USA

P2.80

Generalized Disruption in Genomic Imprinting Leads to Placental Defects in Lipid Transport Katherine Himes1,2, Alexandria Young1,2, John Chaillet1,2, 1Magee-Womens Research Institute, Pittsburgh PA, USA, 2University of Pittsburgh, Pittsburgh PA, USA

P2.81

Prevention of placental insufficiency in the type 2 diabetic New- Zealand obese mice by pre-pregnancy administration of macrolide-immunosuppressant tacrolimus Ahmad J.H. Albaghdadi1, Melanie A. Hewitt1, Shan-Shan Gu1, Frederick W.K. Kan1, 1Queen's University, Kingston, Ontario, Canada

P2.82

Is TMED2 essential in the chorion for normal interaction between the allantois and the chorion in mice? Wenyang(Dominic) Hou1, Didem Sarikaya3, Loydie Jerome-Majewska1,2, 1Department of Human Genetics, McGill University, Montreal, Canada, 2Montreal Children Hospital Research Institute, Montreal, Canada,

3Organismic and Evolutionary Biology Department, Harvard University, Cambridge, USA

P2.83

Sensitivity and specificity of echography in the diagnosis of placental accretism in patients with diagnosis of placenta praevia Giulia Garofalo1, Eleonora Pilloni1, Maria Grazia Alemanno1, Pietro Gaglioti1, Andrea Sciarrone1, Olga Sochirca1, Manuela Oberto1, Michela Chiadò Florio Tin1, Simona Bastonero1, Carlotta Pace1, Elena Olearo1, Elsa Viora1, Alessandro Rolfo1, Tullia Todros1, 1University of Turin, Dept. of Surgical Sciences, Turin, Italy

P2.84

The role of excessive autophagy in preeclamptic pathologenesis Hua Zhang1, Li Gao1, Kamana K.C1, Xuemei Zhang1, Hongbo Qi1, 1Chongqing Medical University, Chongqing, China

P2.85

Maternal Nodal inversely affects NODAL and STOX1 expression in the fetal placenta Hari Thulluru1, Craig Park2, Daniel Dufort2, Gunilla Kleiverda3, Cees Oudejans1, Marie van Dijk1, 1VU University Medical Center, Amsterdam, The Netherlands, 2McGill University, Montreal, Canada, 3Flevo Hospital, Almere, The Netherlands


P2.86

Placental energy depletion in early-onset preeclampsia: role of eIF2a signalling in mitochondrial activity Hong wa Yung1, Francesca Colleoni1, Matts Olovsson2, John Kingdom3, Graham Burton1, 1University of Cambridge, Cambridge, UK, 2University of Uppsala, Uppsala, Sweden, 3University of Tornoto, Tornoto, Canada

P2.87

Trophoblastic debris shed from molar placentae activates endothelial cells Min Zhao1, Man Wu1, Yongxiang Yin1, Hai Xin1, Larry Chamley2,1, Qi Chen2,1, 1Wuxi Maternity and Children Hospital, Nanjing Medical University, Wuxi, China, 2Department of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand

P2.88

Widespread DNA hypomethylation at gene enhancer and low CpG density regions in placentas associated with early-onset preeclampsia John Blair1, Ryan Yuen2, Brendan Lim1, Deborah McFadden1, Peter von Dadelszen1, Wendy Robinson1, 1University of British Columbia, Vancouver, BC, Canada, 2University of Toronto, Toronto, ON, Canada

P2.89

Morphology of the mouse mesometrial decidua during early pregnancy ALEX KORS VIDSIUNAS1, SÉRGIO FERREIRA DE OLIVEIRA2, 1NOVE DE JULHO UNIVERSITY, SÃO PAULO-SP, Brazil, 2UNIVERSITY OF SÃO PAULO, SÃO PAULO-SP, Brazil

P2.90

Morhpophysiological alteration of uterine artery. Doppler-velocimetry as a predictor for preeclampsia ALEX KORS VIDSIUNAS1,2, JANISE DALPAI1,4, CRISTIANE REGINA RUIZ1, NADER WAFAE1,3, 1SÃO CAMILO COLLEGE, SÃO PAULO-SP, Brazil, 2NOVE DE JULHO UNIVERSITY, SÃO PAULO-SP, Brazil, 3OESTE PAULISTA UNIVERSITY, SÃO PAULO-SP, Brazil, 4FEDERAL UNIVERSITY OF SÃO PAULO, SÃO PAULO-SP, Brazil

P2.91

Identification of molecular subclasses of preeclampsia Shannon Bainbridge1,2, Brian Cox3, 1Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada, 2Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, 3Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

P2.92

Matricellular CCN1 and CCN3 proteins are key regulators at the fetal-maternal interface by promoting cell cycle exit and migration of extravillous trophoblast cells Friederike Kipkeew1, Diana Klein2, Manuela Wülling3, Guy Whitley4, Elke Winterhager1, Alexandra Gellhaus1, 1Institute of Molecular Biology, University of Duisburg-Essen, Essen, Germany, 2Institute of Cell Biology, University of Duisburg-Essen, Essen, Germany, 3Department of Developmental Biology, Essen, Germany, 4Division of Basic Medical Sciences, St George’s University of London, London, UK

P2.93

Trophoblast invasion and macrophage populations in the mesometrial triangle in a preeclampsia rat model Floor Spaans1, Chiwan Chiang1, Theo Borghuis2, Gea Kiewiet1, Pieter Klok2, Winston Bakker2, Marijke Faas1, 1Div. of Medical Biology, Dept. of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands, 2Div. of Pathology, Dept. of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands

P2.94

Hsp70 transcription is positively regulated by HIF-1α in in vitro models of human placental hypoxia Ji Kwon Park1, Ji Hye Lee1, Mi Hyun Park1, In Young Choi1, Eun Young Jung1, Yoon Kyoung Lee1, Jin Suk Suk1, 1Gyeongsang National University, Jinju, Republic of Korea


P2.96

Placental glucose transporter GLUT1 expression in pre-eclampsia Camilla Marini1,4, Benjamin P. Lüscher1, Daniel V. Surbek2, Marianne Messerli1, Ruth Sager1, Christiane Albrecht3, Matthias A. Hediger3, Marc Baumann2, 1Department of Clinical Research, University of Bern, Bern, Switzerland, 2Department of Obstetrics and Gynecology, University Hospital of Bern, Bern, Switzerland,

3Institute for Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland, 4Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

P2.97

Hypoxia alters syncytiotrophoblastic microparticles (STBM)-related coagulation capacities Claudia Göhner1, Carolin Bonnke2, Maik Sossdorf2, Wolfgang Lösche2, Ekkehard Schleußner1, Udo R. Markert1, Justine S. Fitzgerald1, 1University women hospital Jena, Jena, Thuringia, Germany, 2University Hospital Jena Department of Anesthesiology and Intensive Medicine, Jena, Thuringia, Germany

P2.98

HTR8/SVneo, but not JEG3, cells display trophoblast progenitor cell-like characteristics indicative of self-renewal, repopulation activity and expression of “stemness”- associated transcription factors Maja Weber1, Ilka Knoefler1, Ekkehard Schleußner1, Udo R. Markert1, Justine S. Fitzgerald1, 1University women hospital Jena, Jena, Thuringia, Germany

P2.99

SUMO4 - a novel functional candidate in the placental protein SUMOylation machinery Dora Baczyk1, Sascha Drewlo1,2, Khrystyna Levytska1, John Kingdom1,3, 1Samuel Lunenfeld Research Inst, Toronto, ON, Canada, 2Wayne State University School of Medicine, Detroit, MI, USA, 3Dept of Ob/Gyn., University of Toronto, Toronto, ON, Canada

P2.100

Effects of heparin treatment on regulating cell proliferation in the mouse placenta Farshad Ghasemi1,2, John Kingdom3,4, Sascha Drewlo5, S.Lee Adamson1,4, 1Samuel Lunenfeld Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, 2University of Toronto, Department of Physiology, Toronto, Ontario, Canada, 3Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, Ontario, Canada, 4Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada, 5C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan, USA

P2.101

Trophoblasts and macrophages inhibit angiogenesis of term human placental endothelial cells in a paracrine manner Jelena Bilic1,2, Ursula Hiden2, Ingrid Lang2, Berthold Huppertz2, Gernot Desoye1, 1Department of Obstetrics and Gynecology, Graz, Styria, Austria, 2Institute of Cell Biology, Histology and Embryology, Graz, Styria, Austria

P2.102

Transgenerational effects of abnormal folate metabolism on fetal and placental development Nisha Padmanabhan1, Wendy Jia2, Colleen Geary-Joo2, Xuchu Wu2, Anne Ferguson-Smith1, Roy Gravel2, James Cross2, Erica Watson1, 1University of Cambridge, Cambridge, UK, 2University of Calgary, Calgary, Canada

P2.103

Placenta-specific loss ofautophagy predisposes the offspring to obesity and hyperglycemia Alina Maloyan1, Sribalasubashini Muralimanoharan1, Leslie Myatt1, 1University of Texas Health Science Center, San Antonio, USA

P2.104

Meta-analysis of transcriptome data reveals novel molecular pathways related to preeclampsia Gijs Afink1, Miranda van Uitert1, Perry Moerland1, Joris van der Post1, Carrie Ris-Stalpers1, 1Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

P2.105

Stress induces placental differentiation from stem cells that is differenti in seven ways compared with normal differentiation Daniel Rappolee1, Zhongliang Jiang1, Sichang Zhou1, Awoniyi Awonuga1, Yufen Xie1, Elizabeth Puscheck1, 1Wayne State University, Detroit, MI/Midwest, USA


P2.106

Sex-specific differences in the sheep placenta Thorsten Braun1, Wenbin Meng1,4, Hongkai Shang1,5, Shaofu Li7, Deborah Sloboda2, Loreen Ehrlich1, Huaisheng Xu1,6, Wolfgang Henrich1, Joachim Dudenhausen1, Andreas Plagemann1, John Newnham7, John Challis3, 1Departments of Obstetrics and Division of Experimental Obstetrics, Study Group in Perinatal Programming, Charite University Berlin, Berlin, Germany, 2Departments of Biochemistry and Biomedical Sciences, Obstetrics & Gynecology and Pediatrics, McMaster, Hamilton, Canada, 3Department of Physiology, Obstetrics and Gynecology, University of Toronto, Ontario, Canada; Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada and Dept Obstetric, Perth, Australia, 4The Affiliated Hospital to Inner Mongolia Medical College, Inner Mongolia, China, 5Hangzhou first people’s hospital, Zhejiang, China,

6Department of Obstetrics and Gynecology, Linyi people’s hospital, Lanshan, China, 7School of Women’s and Infants’ Health, King Edward Memorial Hospital and Women and Infants Research Foundation of Western Australia, Perth, Australia

P2.107

Early maternal dexamethasone administration and the effect on ovine placental lactogen Thorsten Braun1, Wenbin Meng1,2, Hongkai Shang1,3, Shaofu Li4, Deborah Sloboda5, Loreen Ehrlich1, Huaisheng Xu1,6, Wolfgang Henrich1, Joachim Dudenhausen1, Andreas Plagemann1, John Newnham4, John Challis7,4, 1Departments of Obstetrics and Division of Experimental Obstetrics, Study Group in Perinatal Programming Charite University Berlin, Berlin, Germany, 2The Affiliated Hospital to Inner Mongolia Medical College, Inner Mongolia, China, 3Hangzhou first people’s hospital, Zhejiang, China, 4School of Women’s and Infants’ Health, King Edward Memorial Hospital and Women and Infants Research Foundation of Western Australia, The University of Western Australia, Perth, Australia, 5Depts of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, China, 6Department of Obstetrics and Gynecology, Linyi people’s hospital, Lanshan, China, 7Department of Physiology, Obstetrics and Gynecology at the University of Toronto and Faculty of Health Sciences, Simon Fraser University, Vancouver, Canada

P2.108

Infantile Haemangioma: A placental derived tumour with involvement of the renin angiotensin system Tinte Itinteang1, Reginald Marsh1, Paul Davis1,2, Swee Tan1,2, 1Gillies McIndoe Research Institute, Wellington, New Zealand, 2University of Otago, Wellington, New Zealand

P2.109

Infantile Haemangioma: A tumour derived from placental mesenchymal villous core cells with capacity for mesenchymal transition Cherise Tan1, Tinte Itinteang1, Liz Jones1, Helen Brasch1, Paul Davis1,2, Swee Tan1,2, 1Gillies McIndoe Research Institute, Wellington, New Zealand, 2Univeristy of Otago, Wellington, New Zealand

P2.110

The transfer of rivaroxaban across the dually perfused human placenta Priya Bapat1, Nir Melamed1, Angelika Lubetsky1, Howard Berger1, Gideon Koren1, 1Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada

P2.111

Modelling oxygen transport in the human placenta Alexander Serov1, Denis Grebenkov1, Carolyn Salafia2, Marcel Filoche1, 1Laboratoire PMC, CNRS - École Polytechnique, 91128, Palaiseau Cedex, France, 2Placental Analytics LLC, 93 Colonial Avenue, Larchmont, New York 10538, USA

P2.112

Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation Kerry A Burke1, Eric Jauniaux2, Graham J Burton1, Tereza Cindrova-Davies1, 1University of Cambridge, Cambridge, UK, 2University College London, London, UK

P2.113

Transplacental permeability of hydrophilic physiological substances determined by fetus uptake index method Hideki Ozawa1, Tomohiro Nishimura1, Akira Katsube1, Masatoshi Tomi1, Emi Nakashima1, 1Keio University, Minato-ku, Tokyo, Japan


P2.114

Screening strategy and first results for the identification of novel membrane transporter targets in IUGR and pre-eclampsia Xiao Huang1,2, Pascale Anderle1,2, Edgar Ontsouka1,2, Arjun Jain1,2, Daniel Surbek1,3, Marc Baumann1,3, Christiane Albrecht1,2, 1Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, Bern, Switzerland, 2Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland, 3Department of Obstetrics and Gynecology, University Hospital, University of Bern, Bern, Switzerland

P2.115

Estrogen receptor-mediated induction of Abcg2 transporter by mitoxantrone in rat placental trophoblast cells Masatoshi Tomi1, Kenji Oda1, Tomohiro Nishimura1, Emi Nakashima1, 1Keio University Faculty of Pharmacy, Minato-ku, Tokyo, Japan

P2.116

Placental uric acid transport system Benjamin P. Lüscher1, Benjamin Clémençon2, Daniel V. Surbeck3, Xiao Huang2,4, Camilla Marini1,4, Matthias A. Hediger2, Christiane Albrecht2, Marc Baumann3, 1Department of Clinical Research, Bern, Switzerland,

2Institute for Biochemistry and Molecular Medicine, Bern, Switzerland, 3Department of Obstetrics and Gynecology, Bern, Switzerland, 4Graduate School for Cellular and Biomedical Sciences, Bern, Switzerland

P2.117

Proteomic analysis of the trophoblastic basal membrane fraction from BeWo cells Soo-young Oh1, Jae Ryoung Hwang2, Jung-Joo An1, Suk-Joo Choi1, Jung-Sun Kim3, Jong-Hwa Kim1, Yoel Sadovsky4, Cheong- Rae Roh1, 1Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 2Samsung biomedical research institute, Samsung Medical Center, Seoul, Republic of Korea, 3Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 4Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA

P2.118

Vaccinium angustifolium var. laevifolium House (Lowbush blueberry) leaf extract increases trophoblast migration Christina Ly1,2, Julien Yockell-Lelièvre2, Lana Saciragic5, Ammar Saleem3, Jonathan Ferrier3,4, John Thor Arnason3, Andrée Gruslin2,5, 1Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada, 2Ottawa Hospital Research Institute, Ottawa, ON, Canada, 3Centre for Research in Biotechnology and Biopharmaceuticals, University of Ottawa, Ottawa, ON, Canada, 4The New York Botanical Garden, Institute of Economic Botany, Bronx, NY, USA, 5Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa, ON, Canada

P2.119

Endoglandular trophoblasts disintegrate and replace uterine glandular epithelium in vitro and in situ Gerit Moser1, Gregor Weiss1, Monika Sundl1, Martin Gauster1, Berthold Huppertz1, 1Medical University of Graz, Graz, Austria

P2.120

Postpartum women’s perspectives on the donation of the placenta for scientific research and therapeutic applications in Campinas, Sao Paulo, Brazil Rebecca Scott Yoshizawa1, Maria José Duarte Osis2, Simony Lira do Nascimento3, José Guilherme Cecatti3, Ana Carolina Godoy3, Suelene Coelho3, 1Queen's University, Kingston, Ontario, Canada, 2CEMICAMP, State University of Campinas, Campinas, Sao Paulo, Brazil, 3CAISM, State University of Campinas, Campinas, Sao Paulo, Brazil


P2.121

Annexin 5 involvement in human trophoblast fusion Severine Degrelle1,3, Pascale Gerbaud1,2, Anthony Bouter4, Jean Guibourdenche1,5, Alain Brisson4, Daniele Evain-Brion1,3, Guillaume Pidoux1,2, 1INSERM, UMR-S 767, Faculté des Sciences Pharmaceutiques et Biologiques, Paris F-75006, France, 2Université Paris Descartes, Paris F-75006, France, 3PremUP, Foundation, Faculté des Sciences Pharmaceutiques et Biologiques, Paris F-75006, France, 4UMR CNRS 5248 CBMN - Université Bordeaux 1, Pessac F-33600, France, 5AP-HP, Biologie Hormonale, CHU Cochin, Paris F-75014, France

P2.122

The exocyst complex and trophoblast differentiation Isabel M. Gonzalez1, William E. Ackerman1, Dale D. Vandre1, John M. Robinson1, 1Ohio State University, Columbus, OH, USA

P2.123

Effects of IGFBP-4 and -5 on trophoblast migration Erin Crosley1, Julian Christians1, 1Simon Fraser University, Burnaby, British Columbia, Canada

P2.124

Sphingosine-1-phosphate (S1P) inhibits extravillous trophoblast migration via S1P receptor 2 Khiria Al-Saghir1, Daman Adlam1, Melissa Westwood1, Edward Johnstone1, 1University of Manchester, Manchester, UK

P2.125

Inhibition of phosphodiesterase 4 promotes differentiation and fusion of BeWo choriocarcinoma cells Gavin Collett1, Eleni Fotaki1, Christopher Redman1, Ian Sargent1, 1University of Oxford, Oxford, UK

P2.126

Angiomotin: A new player in the regulation of trophoblast cell polarity Andrea Tagliaferro1, Isabella Caniggia1,2, 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital;, Toronto, Canada, 2Departments of Physiology and Obstetrics & Gynaecology, University of Toronto,, Toronto, Canada

P2.127

Lost in transcription: a comparative microarray analysis of the trophoblast stem cell niche in mouse and huam Matteo Moretto Zita1, Francesca Soncin1, Kristopher Nazor2, Louise Laurent1, Mana Parast1, 1University of California San Diego, La Jolla, CA, USA, 2The Scripps Research Institute, La Jolla, CA, USA

P2.128

Stromal cell derived factor 2: new insights of function Aline R. Lorenzon1, Cristiane R. Guzzo1, Chuck S. Farah2, Susan J. Fisher3, Estela Bevilacqua1, 1Insitute of Biomedical Sciences - University of Sao Paulo, Sao Paulo - SP, Brazil, 2Institute of Chemistry - University of Sao Paulo, Sao Paulo - SP, Brazil, 3School of Medicine - University of California San Francisco, San Francisco - CA, USA

P2.129

Vasculogenic mimicry in three-dimensional cultures of murine trophoblast stem cells Anshita Rai1, Malgorzata Gasperowicz1, James (Jay) Cross1, 1University of Calgary, Calgary, Alberta, Canada

P2.130

Influence of hyperglicemia in pro-inflamatory cytokine levels in serum and placenta S. Corrêa-Silva1,2, JB Moreli1, L De Rosa1, DC Damasceno1, MVC Rudge1, E Bevilacqua2, IMP Calderon1, 1Botucatu Medical School, UNESP – São Paulo State University, São Paulo, Brazil, 2Laboratory Biology of the Trophoblast Research, Institute of Biomedical Sciences, University of São Paulo - USP, São Paulo, Brazil

P2.131

Deregulation of miRNAs from nuclear reprogramming errors occurred during placentogenesis in cloned pregnancy Md Munir Hossain*1,2, Dawit Tesfaye2, Karl Schellander2, Mechael Hoelker2, 1Bangladesh Agricultural University, Mymensingh, Bangladesh, 2 University of Boonn, Bonn, Germany


P2.132

Protein expression by proteomic analysis in pregnancy of placenta accreta Te Yao Hsu*, Chih Chang Tsai, Chia Yo Ou, Tiao Hsien Hung, Kaohsiung chang Gung Memorial Hospital, Kaohsiung, Taiwan


New Investigator Travel Awards 2013

Y.W. Loke New Investigator Travel Awards Kristiina Aasa, Canada

Mahroo Aghababaei, Canada

Ahmad J.H. Albaghdadi, Canada

Patji Alnæs-Katjavivi, Norway

Jelena Bilic, Austria

Volker U. Buck, Germany

Sarah Chauvin, Canada

Man-Kin Chung, Hong Kong

Leonardo Ermini, Canada

Phelipe Favaron, Brazil

Allison Felker, Canada

Valerie Fock, Austria

Farshad Ghasemi, Canada

Sylvie Girard, UK

Tilini Gunatillake, Australia

Natalie Hannan, Australia

Josephine Higgins, UK

Xiao Huang, Switzerland

Qi-tao Huang, China

Modou Lamin Jobarteh, UK

Sarah Jones, UK

Peeter Juhanson, Estonia

Gina Kusuma, Australia

Yan Li, Canada

Michael Litvack, Canada

Aline R. Lorenzon, Brazil

Liangjian Lu, UK

Christina Ly, Canada

Camilla Marini, Switzerland

Gerit Moser, Austria

Cornelia Muschol-Steinmetz, Germany

Anna Maria Nuzzo, Italy

Bo Peng, Canada

Anshita Rai, Canada

Hester Roberts, New Zealand

Zarqa Saif, Australia

Astrud Tuck, Australia

Gregor Weiss, Austria

Kate Widdows, UK

Cristian Zenerino, Italy


National Institutes of Health New Investigator Travel Awards Kanaga Arul Nambi Rajan, USA

Irving Aye, USA

William E. Gundling , USA

Roberta Hannibal, USA

Susmita Jasti, USA

Susanne Lager, USA

Matteo Moretto Zita, USA

Khaled Omar, USA

Stephen J. Renaud, USA

Mauro Schenone, USA

Geetu Tuteja, USA


IFPA Awards

New Investigator Oral Award

Presentations will be judged by a panel and will be eligible for The Elsevier Placenta New Investigator Award. The award “acknowledges the best oral presentation by a new investigator in the field of placentology in all its aspects, including the relationship with fetus and mother” and consists of 1000 Euros and free one-year access to Elsevier Science Direct. The award winner will be announced at the Gala Dinner on Saturday, September 14. New Investigator Poster Award Presentations will be judged by a panel for the Elsevier Trophoblast Research Award, which “acknowledges

the best poster presentation by a new investigator in the field of placentology in all its aspects, including the

relationship with fetus and mother” and comprises $1500 USD, an invitation to present your work at the next

year’s IFPA meeting and free one-year access to Elsevier Science Direct.

The 10 invited finalists will be judged at noon on Saturday, September 14 in a designated area of the

Conference Centre lobby. The finalist names will be posted as soon as possible after the second poster

session concludes.

The award winner will be announced at the Gala Dinner on Saturday, September 14.

Y.W.

Loke New Investigator Travel Awards (annual award)

Support for New Investigators in Placentology to attend IFPA meetings.

New investigators are defined as students or researchers in full-time training or researchers who are within

three years of their senior degree (e.g. Ph.D., M.D.).The awards are based on a review of abstracts submitted

for an IFPA-designated meeting.

National Institutes of Health New Investigator Travel Awards

These travel awards are to enable US-based new investigators in any aspect of placental research to attend

the annual meetings of IFPA. New investigators are defined as students or researchers in full-time training or

researchers who are within three years of their senior degree (e.g. Ph.D., M.D.).

The awards are based on a review of abstracts submitted for an IFPA-designated meeting.

IFPA Award in Placentology (awarded every other year in odd years 2011, 2013, 2015 etc.)

The "IFPA Award in Placentology" acknowledges outstanding contributions to the field of placentology in all

its aspects, including the relationship with fetus and mother by established investigators who are normally

within 20 years of receipt of their terminal degree.

Award: The IFPA Award consists of $2000 USD plus accommodation and registration at next meeting. The

awardee will be invited to present a lecture during a plenary session of the same IFPA-designated meeting.

The lecture will be published in "Trophoblast Research" following normal peer review procedures.

IFPA Senior Award in Placentology (awarded every year)

The "IFPA Senior Award in Placentology" is intended to recognise the work of established senior

scientists/clinicians who have led placental research groups for a substantial period of time and have made a

significant contribution to our understanding of placental and reproductive functions in general. Awardees


will be able to demonstrate a sustained commitment to the development of younger placental researchers

and to the placental/reproductive research community in general. As a guide to nominators, applicants with

20 years or more experience might be appropriate

Award: The IFPA Senior Award represents the highest distinction of the international placental research

community. There will be no monetary prize associated with the Award. However, up to $1500 will be

reimbursed towards economy class airfare. The awardee will be invited to present a lecture during a plenary

session of the same IFPA-designated meeting. The lecture will be published in "Trophoblast Research"

following normal peer review procedures.


Delegate Statistics

Australia 13 Lebanon 1

Austria 9 Mexico 2

Brazil 7 Netherlands 4

Canada 85 New Zealand 5

Chile 1 Norway 4

China 5 Saudi Arabia 1

Denmark 3 South Africa 1

Estonia 2 South Korea 12

France 7 Sweden 2

Germany 10 Switzerland 5

Indonesia 2 Taiwan 1

Italy 5 United Kingdom 27

Japan 16 United States 61

Total delegates 293

Australia Austria

Brazil

Canada

Chile

China

Denmark

Estonia

France

Germany Indonesia

Italy

Japan

Lebanon

Mexico Netherlands

New Zealand

Norway

Saudi Arabia

South Africa

South Korea

Sweden

Switzerland

Taiwan

United Kingdom

United States

Delegate Demographics by Nationality


Delegate List

Aasa, Kristiina Canada

Abumaree, Mohamed Saudi Arabia

Ackerman, IV, William United States

Adamson, S Lee Canada

Afink, Gijs The Netherlands

Aghababaei, Mahroo Canada

Ahmed, Tasfia Canada

Alahari, Sruthi Canada

Albaghdadi, Ahmad Canada

Albrecht, Christiane Switzerland

Alnaes-Katjavivi, Patji Norway

Ambrosio, Carlos Brazil

Araki, Hikari Japan

Arul Nambi Rajan, Kanaga United States

Aye, Irving United States

Baczyk, Dora Canada

Bainbridge, Shannon Canada

Bapat, Priya Canada

Baumann, Marc Switzerland

Beristain, Alexander Canada

Bevilacqua, Estela Brazil

Bhattacharjee, Jayonta Canada

Bianchi, Diana United States

Bilic, Jelena Austria

Bilodeau, Jean-Francois Canada

Bourque, Stephane Canada

Brannon, Patsy United States

Braun, Thorsten Germany

Brownbill, Paul United Kingdom

Buck, Volker U. Germany

Burton, Graham United Kingdom

Caniggia, Isabella Canada

Care, Alison Canada

Carter, Anthony M. Denmark

Carvalho Moreira de Mello, Joana Brazil

Castillo, Christian Chile

Chaemsaithong, Piya United States

Chaffin, Donald United States

Chaillet, Richard United States

Chamley, Larry New Zealand

Chauvin, Sarah Canada

Chavatte-Palmer, Pascale France

Chen, Chie-Pein Taiwan

Chen, Moy Fong Canada

Chen, Qi New Zealand

Cho, Yeonkyung South korea

Christians, Julian Canada

Chui, Amy Australia

Chung, Man-Kin Hong Kong

Classen-Linke, Irmgard Germany

Clifton, Vicki Australia

Collett, Gavin United Kingdom

Collins, Sally United Kingdom

Cotechini, Tiziana Canada

Cox, Brian Canada

Crosley, Erin Canada

Cross, Jay Canada

Croy, (B.) Anne Canada

Cureton, Natalie England

Dantzer, Vibeke Denmark

Daoud, Georges Lebanon

Degrelle, Severine France

Desoye, Gernot Austria

Dilworth, Mark United Kingdom

Dolberg Anderson, Ulrik Sweden

Drewlo, Sascha United States

Dunk, Caroline Canada

Eguchi, Hiromi Japan

Enders, Allen United States

Ermini, Leonardo Canada

Esche, Emily United States

Evain-Brown, Daniele France

Faas, Marijke The Netherlands

Favaron, Phelipe Canada

Felker, Allison Canada

Fitzgerald, Justine S. Germany

Fock, Valerie Austria

Fournier, Thierry France

Frias, Antonio United States

Galdino, Daniel Brazil

Gasperowicz, Malgorzata Canada

Gellhaus, Alexandra Germany

Ghasemi, Farshad Canada

Girard, Sylvie United Kingdom

Giuffrida, Domenica Italy

Golos, Ted United States


Gonzalez-Barrios, Juan-Antonio Mexico

Graham, Charles Canada

Groten, Tanja Germany

Gruslin, Andree Canada

Gudavalli, Madhu United States

Guibourdenche, Jean France

Gunatillake, Tilini Australia

Gundling, William United States

Gundogan, Fusun United States

Hannan, Natalie Australia

Hannibal, Roberta United States

Hanson, Emily United States

Hansson, Stefan Sweden

Harris, Lynda United Kingdom

Hemberger, Myriam United Kingdom

Hemmings, Denise Canada

Hichijo, Atsuko Japan

Higgins, Josephine United Kingdom

Host, Amanda United Kingdom

Hu, Yuxiang Canada

Huang, Xiao Switzerland

Huang, Joseph Canada

Hutabarat, Martina Indonesia

Hwang, Jae Ryoung Korea

Illsley, Nicholas United States

Isaac, Sarah Canada

Ishikawa, Gen Canada

Iversen, Ann-Charlotte Norway

James, Jo New Zealand

Jansson, Thomas United States

Jasti, Susmita United States

Jobareth, Moudou Lamin United Kingdom

Johnsen, Guro Mørk Norway

Jones, Helen United States

Jones, Sarah United Kingdom

Juhanson, Peeter Estonia

Jurisicova, Andrea Canada

Kalionis, Bill Australia

Kamide, Taizan Japan

Keating, Sarah Canada

Keiko, Koide Japan

Kerage, Daniel Canada

Kibschull, Mark Canada

Kil, Kicheol Republic of Korea

KIM, Chong Jai South Korea

Kim, Jung-Sun Republic of Korea

Kim, Eun Na Republic of Korea

Kim, Hyun Joo Republic of Korea

Kim, Soo Hyun South Korea

King, Anna England

Kingdom, John Canada

Knöfler, Martin Austria

Kniss, Douglas United States

Kolahi, Kevin United States

Koppes, Erik United States

Kremshofer, Julia Austria

Krishnan, Lakshmi Canada

Kulandavelu, Shathiyah United States

Kusama, Kazuya Japan

Kusuma, Gina Australia

Kwak, Dong Wook Republic of Korea

Kwan, Melissa Canada

Lacko, Lauretta United States

Lager, Susanne United States

Lala, Peeyush Canada

Lao, Terence T Hong Kong

Leach, Lopa United Kingdom

Leavey, Katie Canada

Lee, Yeri Republic of Korea

Leon-Garcia, Sandra M United States

Letarte, Michelle Canada

Lewis, Rohan United Kingdom

Li, Huika Australia

LI, Yan Canada

Li, Yingchun United States

Litvack, Michael Canada

Liu, Wei United States

Lorenzon, Aline Brazil

Lu, Chi-Wei United States

Lu, Liangjian United Kingdom

Lutsevich, Natalia United States

Ly, Christina Canada

Lye, Phetcharawan (Tam) Canada

Lye, Stephen Canada

MacPhee, Daniel Canada

Margaret, Petroff United States

Marini, Camilla Switzerland

Markert, Udo R. Germany

Mary, Stella Germany

Matjila, Mushi South Africa

McFadden, Deborah Canada

McGowen, Michael United States


Milstone, David United States

Motero-Rojas, Aridahyd Mexico

Morales-Prieto, Diana Maria Canada

Moretto-Zita, Matteo United States

Morgan, Terry Canada

Morine, Mikio Japan

Morrish, Donald Canada

Morton, Jude Canada

Moser, Gerit Austria

Murphy, Shawn United States

Murthi, Padma Australia

Muschol-Steinmetz, Cornelia Germany

Myatt, Leslie United States

Nagy, Andras Canada

Nevo, Ori Canada

Nosi, Ursula Canada

Nuzzo, Anna Maria Italy

Odame, Jodie Canada

Oh , Soo-young South Korea

Olomu, I. Nicholas United States

Omar, Khaled Canada

O'Tierney-Ginn, Perrie United States

Ozawa, Hideki Japan

Parast, Mana United States

Park, Ji Kwon South Korea

Peñaherrera , Maria S. Canada

Pehrson, Caroline Denmark

PENG, BO Canada

Pollheimer, Jurgen Austria

Portilho, Nathália Brazil

Post, Martin Canada

Powell, Theresa United States

Ptacek, Imogen United Kingdon

Qi-tao, Huang China

Rai, Anshita Canada

Rappolee, Daniel Canada

Redman, Christopher United Kingdom

Renaud, Stephen United States

Rennie, Monique United States

Renshall, Lewis United Kingdom

Rice, Gregory Australia

Roberts, Claire Australia

Roberts, Victoria United States

Roberts, Hester New Zealand

Robinson, John M. United States

Robinson, Wendy Canada

Rolfo, Alessandro Italy

Ronzoni, Stefania Canada

Rytting, Erik United States

Sõber, Siim Estonia

Sadovsky, Yoel United States

Salafia, Carolyn United States

Salomon, Carlos Australia

Schenone, Mauro United States

Scherjon, Sicco The Netherlands

Schneider, Henning Switzerland

Seabrook, Jill Canada

Sekhon, Prabhjot Canada

Senger, Christof Canada

Serghides, Lena Canada

Serov, Alexander France

Shiverick, Kathleen United States

Simon, Celeste Canada

Sled, John G Canada

Sood, Rashmi United States

Spaans, Floor Netherlands

Staff, Anne Cathrine Norway

Tagawa, Naomi Japan

Tagliaferro, Andrea Canada

Tannetta, Dionne United Kingdom

Tarrade, Anne France

Tatsuzuki, Ayano Japan

Thornburg, Kent United States

Tinte, Itinteang New Zealand

Todros, Tullia Italy

Tomi, Masatoshi Japan

Tong, Stephen Australia

Tuck, Astrud Australia

Tunster, Simon United Kingdom

Tuteja, Geetu United States

Umehara, Nagayoshi Japan

Vaillancourt, Cathy Canada

van der Post, Joris The Netherlands

Van Dijk, Marie The Netherlands

Varmuza, Susannah Canada

Vidsiunas, Alex Kors Brazil

Wadsack, Christian Austria

Wallace, Alison United Kingdom

Wang, Kai China

Wareing, Mark United Kingdom

Watson, Erica United Kingdom

Weiss, Gregor Austria


Westwood, Melissa United Kingdom

Whitley, Guy United Kingdom

Wibowo, Noroyono Indonesia

Widdows, Kate United Kingdom

Wildman, Derek United States

Wong, Frances Canada

Xiao, Xiaoqiu Canada

Yockell-Lelievre, Julien Canada

Yoshie, Mikihiro Japan

Yoshizawa, Rebecca Canada

Yung, Hong wa United Kingdom

Zamudio, Stacy United States

Zavan, Bruno Canada

Zenerino, Cristian Italy

Zhang, Hua China

Zhang, Jianhong Canada

Zhou, Cissy Chenyi United States

Zhu, Hua Canada

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