vaccine technology. newer technology for dosing:
TRANSCRIPT
• Old Technology:– Grow in animals (vaccinia
in calves for smallpox; rabbit brains for rabies)
– Simple bacterial culture (Cholera vibrio) then inactivation
– Grow in eggs (influenza, vaccinia) then inactivate
>100 million eggs used for influenza in the USA every year
Vaccine TechnologyVaccine Technology
Vaccine TechnologyVaccine Technology
• Newer Technology:– Mammalian cell culture: live and killed
vaccines– Subunit vaccines:
• From serum (HBV) or virus / bacterial disruption• Made via recombinant DNA technology
– Recombinant vaccine vectors– DNA vaccines