vaccine impact and value of vaccination looking at ... · comparisons: cyd tdv dengue vaccine...
TRANSCRIPT
![Page 1: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/1.jpg)
VACCINE IMPACT AND VALUE OF VACCINATIONLOOKING AT BENEFITS BEYOND EFFICACY AND SAFETY
Bradford D. Gessner
Vaccinology 2017
III International Symposium for Asia Pacific Experts
Hanoi, Vietnam
October 16-18, 2017
![Page 2: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/2.jpg)
Declarations
• Worked for AMP for 20 years, funding from:– Crucell, GSK, Hilleman, Merck, Novartis, Pfizer, Sanofi– US and French Governments– BMGF– Gavi, the Vaccine Alliance– WHO, Unicef
• Consultant– Sanofi, dengue
• Affiliations– Pfizer: Global Lead for PCV– AMP: Board– U. Maryland: Adjunct professor
2
![Page 3: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/3.jpg)
3
![Page 4: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/4.jpg)
SETTING THE STAGE
![Page 5: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/5.jpg)
Global Introduction Status of Rotavirus Vaccine
Source: International Vaccine Access Center (IVAC), Johns Hopkins Bloomberg School of Public Health. VIEW-hub Global Vaccine
Introduction and Implementation Report, March 2017.
Introduced – National (85)
Introduced – Subnational (7)
56 million unvaccinated
Gavi surviving infants
70% of total
![Page 6: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/6.jpg)
Countries introducing HPV in NIPs as of Nov. 2016Cervical Cancer Action: http://www.cervicalcanceraction.org/comments/comments3.php
6
![Page 7: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/7.jpg)
Foundation is fragile
• Relative value of vaccines critical in every country
• Cost of vaccine transparent and a fact on the ground
• But vaccine benefits need a more robust approach
7
![Page 8: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/8.jpg)
Foundation is fragile
8
![Page 9: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/9.jpg)
FRAMEWORK
![Page 10: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/10.jpg)
FrameworkClinical trial perspective Public health perspective
Context Conservative: should this vaccine be licensed and produced?
Balanced: Should this vaccine be used in my setting?
Endpoints Etiologically confirmed: did the vaccine work against the target etiology?
Clinical: how much disease is preventable regardless of etiologic confirmation at presentation?
Outcomes VE, safety: did the vaccine work and is it safe?
Burden reduction, incidence rate reduction, number needed to vaccinate: what is the efficiency of the vaccine against important outcomes?
Design Individually randomized: does the vaccine provide direct protection?
Cluster randomized: what is the total impact of the vaccine in a population?
Implementation Tightly controlled allocation and intensive disease monitoring: is it certain the vaccine worked?
Public health allocation and routine disease monitoring: what is the expected real world impact?
Trial length Long enough to get trial endpoints : what is the shortest trial that will get endpoints?
Long enough to assess total impact on populationhealth: what does the vaccine prevent over time?
Analysis Per protocol: did vaccine work when delivered to maximize assessment of whether product had biological effect?
ITT + total impact: what was the total (direct + indirect) impact of vaccine in the population when given in real world setting?
First vs. all events First: did the vaccine prevent disease in a high percent of individuals?
All: how many events can the vaccine prevent over the whole follow-up period?
10
![Page 11: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/11.jpg)
ENDPOINTS:CLINICAL INSTEAD OF ETIOLOGICALLY CONFIRMED
![Page 12: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/12.jpg)
Between the idea and the reality, falls the shadow…
OR why reliance on etiologic outcomes fails public health
12
• Field issues• Lack of referral• Lack of transportation• Economic barriers
• Investigator issues• Outcome not suspected• Staff not at work 24/7• Lack of diagnostic equipment
• Laboratory issues• Transportation (delay or loss)• Improperly trained staff• Variable test specificity/sensitivity• Insufficient blood volume• Pre-treatment with antibiotics
• Epidemiological issues• Imperfect entry criteria case definition sensitivity/specificity• Imperfect understanding of outcomes associated with infection (e.g., measles
and malnutrition)• Organism might be part of causal chain and not present
The above may vary by age group, risk group (HIV, marginalized, etc.), geography; often will impact most those most at risk of vaccine preventable disease
![Page 13: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/13.jpg)
Date of download: 4/23/2017© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of
America. All rights reserved. For permissions, e-mail [email protected].
From: Impact of Widespread Introduction of Pneumococcal Conjugate Vaccines on Pneumococcal and
Nonpneumococcal Otitis Media
Incidence dynamics of pneumococcal, nontypable Haemophilus influenzae, culture-negative, and all-cause otitis media
episodes during which middle ear fluid culture was obtained in children aged <36 months in southern Israel, July 2004 through
June 2015. Abbreviations: NTHi, nontypable Haemophilus influenzae; OM, otitis media; PCV, pneumococcal conjugated
vaccine; Pnc, Streptococcus pneumoniae.
Figure Legend:
Clin Infect Dis. 2016;63(5):611-618. doi:10.1093/cid/ciw347
3/1000/yr 3/1000/yr
12/1000/yr
![Page 14: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/14.jpg)
OUTCOMES: PUBLIC HEALTH MEASURES OF DISEASE BURDEN
![Page 15: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/15.jpg)
15
“Disease burden has been consistently mentioned by policymakers
in countries to be the number one factor in setting priorities for
vaccines to be introduced into immunization programs; the higher
the burden, the more attractive a potential addition to the
immunization regime of the country would be.”
Why does burden matter?
• Gates Foundation, Gavi, NITAGs, and WHO SAGE all
emphasize primacy of burden as a criteria for decision making.
• Not burden per se, but the amount of burden a vaccine can
reduce
![Page 16: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/16.jpg)
Public health outcome measures
16
VACCINE PREVENTABLE DISEASE INCIDENCE (VPDI)
• Same as vaccine attributable risk or incidence rate reduction
• = Incidence [unvaccinated] – Incidence [vaccinated]
• = Incidence [unvaccinated] x VE
• = number of cases averted per unit of vaccinated people per year
NUMBER NEEDED TO VACCINATE (NNV)
• The number of people that must be vaccinated to prevent one
outcome
• Not a rate so incorporates length of trial (or duration of immunity)
• If VPDI is reported as cases prevented per 100,000 vaccinated
persons per year, NNV = 100,000/VPDI/length of study
![Page 17: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/17.jpg)
17
![Page 18: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/18.jpg)
EXAMPLES
![Page 19: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/19.jpg)
VPDI (per 1000 CYO) and NNV for etiologically confirmed vs. clinical outcomes
Study Syndrome Etiology confirmed Clinical outcome
VE VPDI NNV VE VPDI NNV
Gambia, PCVLancet 2005;365:1139-46
Radiological pneumonia
70% 1.4 357 37% 13 38
Indonesia, HibLancet 2005;365:43-52
Hospitalized meningitis
86% 0.16 3125 22% 1.6 313
Kenya, rotavirusVaccine 2012;30 (suppl 1):A52-60
AGE (conf. in hospvs. all cause in comm)
84% 33 15 34% 190 3
19
;;
![Page 20: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/20.jpg)
Clinical outcomes show greater VPDI outside of developing country settings
20
Study VE VPDI (per 1000 CYO)
Finland (Vaccine 2012;31:176-82)
Confirmed inpatient AGE 80% 3.9
All cause inpatient AGE 54% 10.7
Kenya (Vaccine 2012;30 Supp 1:A52-60)
Confirmed severe 84% 33
Community severe AGE 34% 190
![Page 21: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/21.jpg)
Clinical outcomes and public health measures can be particularly helpful where burden higher/VE lower
21
Outcome/study VE VPDI (per 1000 CYO)
NNV
Severe rotavirus AGE(NEJM 2010;362:289-98)
S. Africa 77% 42 24
Malawi 49% 67 15
Severe rotavirus AGE(Lancet 2010;376:615-23)
Vietnam 64% 22 33
Bangladesh 43% 35 21
![Page 22: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/22.jpg)
RTS,S VPDI against malaria-specific and all-cause hospitalization
22
![Page 23: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/23.jpg)
VPDI and NNV facilitate vaccine comparisons: CYD TDV dengue vaccine
compared to other vaccines
In Latin America, while severe disease VPDI was relatively low, the VPDI for all hospitalized dengue was approximately equal to the sum of invasive Hib disease and severe pneumonia
VE VPDI NNV
Latin
America
73
239
1707
250
152
800
600
1800
2080
1790
870
0 1000 2000 3000
661
201
28
0
1779
306
448
135
84
97
200
0 1000 2000
NA
CAP: consolidated community acquired pneumonia; NA: not available
96%
80%
65%
26%
100%
10%
22%
9%
40%
42%85%
0% 25% 50% 75% 100%
severe hospitalized VCD cases
hospitalized VCD cases
VCD cases
all pneumonia hospitalization
vaccine serotype invasivepneumococcal disease
CAP with radiographicconfirmation of consolidation…
consolidated CAP
clinically suspected CAP
all cause of severegastroenteritis hospitalization
all cause of gastroenteritishospitalization
confirmed rotavirushospitalization
Den
gue
Hib
Pn
eum
oco
ccu
sR
ota
viru
s
![Page 24: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/24.jpg)
24
0
10
20
30
40
50
60
70
80
90
100
Hib-Hibmeningi s(3
doses)
Rotavirus,SouthAfrica-severerotavirus(2/3
dose)
Pneumococcus-IPD(3doses)
Rotavirus,Vietnam-severe
rotavirus(3doses)
Rotavirus,Malawi-severerotavirus(2/3
dose)
Cholera,Kolka a,India-choleracasesage1-4years(2doses)
Malaria,olderinfants-severemalariadefini on
2inpaper(3doses)
Rotavirus,Bangladesh-
severerotavirus(3doses)
Malaria,infants-severemalariadefini on2inpaper(3doses)
Vaccineeffic
a
cy SUCCESS!!!! FAILURE/EQUIVOCAL
PER PROTOCOL ANALYSIS OF VE
Vaccine 2014;32:3133-8
![Page 25: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/25.jpg)
25
0
1000
2000
3000
4000
5000
6000
7000
8000
Rotavirus,Malawi-severe
rotavirus
Rotavirus,SouthAfrica-severe
rotavirus
Rotavirus,Bangladesh-
severerotavirus
Malaria,olderinfants-severemalariadefini on
2inpaper
Rotavirus,Vietnam-severe
rotavirus
Malaria,youngerinfants-severemalariadefini on
2inpaper
Hib-severepneumonia+suspectedmeningi s
Cholera,Kolka a,India-choleracasesage1-4
years
Pneumococcus-severe
pneumonia+confirme d
pneumococcalmeningi s
VPDIp
er100,000child
-years
PER PROTOCOL ANALYSIS OF VPDI
Vaccine 2014;32:3133-8
![Page 26: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/26.jpg)
VACCINE VALUE IS EXTENSIVE
![Page 27: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/27.jpg)
Vaccine preventable burden is more than incidence rate reduction
[non-severe + severe + sequelae] * [direct + indirect] * [duration of protection] * [total age groups possible to protect]
27
Outbreak reduction
PLUS
PLUS
Political and health system stabilization
PLUS
Equity improvements
PLUS
Ancillary issues (e.g., antibiotic use reduction, fear, stigma)
![Page 28: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/28.jpg)
Severity
Sp/Hibmeningitis
Sp/Hibpneumonia
Malaria Rotavirus Cholera Dengue HPV
Mortality ++++ ++ +++ + ++ + +++
Hospitalization ++++ +++ +++ ++ +++ ++ +
Outpatientdisease
-- + ++++ ++++ + ++++ --
28
![Page 29: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/29.jpg)
Sequelae
Sp/Hibmeningitis
Sp/Hibpneumonia
Malaria Rotavirus Cholera Dengue HPV
Cognitive (MR, DD, LD, language)
++++ -- +++ -- -- -- --
Mental health ++++ -- ? -- -- -- ++++
Sensory (hearing, vision)
++++ -- -- -- -- -- --
Physical (CP,seizures)
++++ -- +++ -- -- -- --
Stunting ? ? +++ + + ? --
29
![Page 30: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/30.jpg)
Indirect effects
30
Sp/Hib Malaria Rotavirus Cholera Dengue HPV
Indirect against unvaccinated same target age cohorts
X ? X X ? X
Indirect against unvaccinated outside of target age cohorts
X ? X ? X
![Page 31: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/31.jpg)
Duration of immunity
Sp/Hib Malaria Rotavirus Cholera Dengue HPV
Relatively long +/-booster
X X
Moderately long (based on existing data)
X X
Short X
Less relevance (almost all disease at young age)
X
31
![Page 32: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/32.jpg)
Age distributionAge <5 yrs disease All age disease Post sexual initiation
disease
Age <5 yrsseverity/sequelae
Rotavirus, Hib Malaria, dengue
All age severity/sequelae
Pneumococcus, cholera
Post sexual initiation severity/sequelae
HPV
32
![Page 33: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/33.jpg)
Equity
Sp/Hib Malaria Rotavirus Cholera Dengue HPV
Occurrence higher in disadvantaged between countries
-- ++++ -- ++++ ++ --
Occurrence higher in disadvantaged within countries
-- ++ -- +++ ++ --
Severity higher in disadvantaged
+ +++ +++ ++ + +++
Mortality higher in disadvantaged
+++ ++++ ++++ +++ + +++
33
![Page 34: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/34.jpg)
Outbreaks and politics
Sp/Hib Malaria Rotavirus Cholera Dengue HPV
Massive outbreaks -- -- -- ++/++++ ++/++++ --
Disruption of health system
-- -- -- ++/++++ ++/++++ --
Politically sensitive -- +++ -- ++++ +++ --
Impact on tourism -- +++ -- ++++ +++ --
34
![Page 35: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/35.jpg)
Impact of the Ebola outbreak on population
health.
J.W.T. Elston, C. Cartwright, P. Ndumbi, J. Wright. The health impact of the 2014–15 Ebola outbreak. Pub Health 2017;143:60-70
28,639 Ebola cases11,316 direct deaths
10,600 additional deaths due to HIV, TB, malariaUnknown number due to maternal deaths, vaccine preventable deaths
Liberia lost 8% of health workersSierra Leone lost 7% of health workers
17,300 orphaned childrenAll schools closed
$2.2 billion loss in GDP$3.6 billion donated
https://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/cost-of-ebola.html
![Page 37: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/37.jpg)
37
![Page 38: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/38.jpg)
Category Specific attribute
Health consideration Premature deaths/year, incident cases/year, QALYs gained/DALYs averted
Economic considerations Directs costs/savings of vaccine use; workforce productivity gained; one-time costs; cost-effectiveness ($/QALY or DALY)
Population that benefits Children, women, disadvantaged, military, other
Public concerns Alternative measures, adverse events, fear of or stigma from disease, pandemic potential
Scientific/business Profitability for manufacturer, new production platforms, existing manufacturing techniques, litigation barriers, NGO interest
Programmatic Improvement in delivery methods, fits existing schedule, reduces cold-chain
Intangible Eradication/elimination of disease, increase public awareness
Policy Interest for national security, foreign policy goals
38
Attributes available on SMART Vaccines
![Page 39: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/39.jpg)
39
https://www.nap.edu/smartvaccines/
Screenshot from SMART Vaccines software
![Page 40: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/40.jpg)
CONCLUSIONS
• Vaccines have large effects beyond direct prevention of first-event etiology-confirmed disease in individuals– But…effects poorly captured
• Areas for improvement:– Different trial designs– More extensive use of clinical endpoints and public health outcome measures
• Incorporation into phase III and IV trials– Broader assessment of social and household consequences of disease/vaccine
impact – Inclusion of ancillary outcomes like equity
• Good data are not good enough– Vaccine community must care about fully assessing a vaccine’s value– Vaccine community should accurately communicate this value– Solutions should be found to overcoming misinformation and pre-existing
biases
40
![Page 41: VACCINE IMPACT AND VALUE OF VACCINATION LOOKING AT ... · comparisons: CYD TDV dengue vaccine compared to other vaccines In Latin America, while severe disease VPDI was relatively](https://reader034.vdocuments.mx/reader034/viewer/2022042410/5f284f49f97dbd41c34e7cab/html5/thumbnails/41.jpg)
41