Prof. Dr Prof. Dr AlaaaAlaaa BasionyBasiony

ProfProf. Dr . Dr hamedhamed AttiaAttiaDepartment of animal medicineDepartment of animal medicineFaculty of veterinary medicine Faculty of veterinary medicine

Zagazig universityZagazig university

VACCINATION PROGRAM IN FARM ANIMAL

*VACCINATION PROGRAM IN FARM ANIMAL

*TYPES OF VACCINE USED

*CAUSES OF VACCINE FAULER

INFECTIOUS VACCINES INFECTIOUS VACCINES (ANTIGENS)(ANTIGENS)

TYPES:TYPES:

–– 11--modified live vaccinesmodified live vaccinesintramuscular,intramuscular, subcutaneous, subcutaneous, intranasalintranasal

IMMUNITY DURATIONIMMUNITY DURATION

–– lifelife--time (infection established, time (infection established, cellular and cellular and humoralhumoral immunity)immunity)

–– one dose requiredone dose required

–– annual boosters may not be requiredannual boosters may not be required

22--NONNON--INFECTIOUS VACCINES INFECTIOUS VACCINES (ANTIGENS)(ANTIGENS)

TYPES:TYPES:

–– killed vaccines and bacterins killed vaccines and bacterins ––intramuscular, subcutaneousintramuscular, subcutaneous

–– toxoids and leukotoxoids toxoids and leukotoxoids ––intramuscular, subcutaneousintramuscular, subcutaneous

IMMUNITY DURATION:IMMUNITY DURATION:

–– 4 4 to to 12 12 months (infection not months (infection not established, established, humoralhumoral immunity)immunity)

–– primary dose required (priming)primary dose required (priming)

–– secondary dose required secondary dose required –– 3 3 to to 6 6 weeks weeks later (within later (within 4 4 months)months)

–– Annual or semiannual boosters requiredAnnual or semiannual boosters required

VACCINE INSTRUCTIONSVACCINE INSTRUCTIONS

FOLLOW THE LABEL:FOLLOW THE LABEL:

refrigerate in use and storagerefrigerate in use and storage

use sanitary practices in useuse sanitary practices in use

keep out of sunlight in usekeep out of sunlight in use

properly dispose of opened vials properly dispose of opened vials after useafter use

Notice expiration date of unopened Notice expiration date of unopened vialsvials

VACCINE LABEL USE DIRECTIONSVACCINE LABEL USE DIRECTIONS

FOLLOW THE LABEL:FOLLOW THE LABEL:

–– dosedose

–– route(s)route(s)

–– withdrawal time for slaughter (withdrawal time for slaughter (21 21 to to 60 60 days)days)

VACCINE FAILURESVACCINE FAILURES

NO RESPONSENO RESPONSE ::

EfficacyEfficacy

stressstress

malnutritionmalnutrition

IMPROPER DOSE:IMPROPER DOSE:

IMPROPER ROUTE:IMPROPER ROUTE:

MISHANDLED MISHANDLED ::

nonnon--refrigeratedrefrigerated

Sunlight exposureSunlight exposure

UnsanitaryUnsanitary

STORED OPENED VIALSSTORED OPENED VIALS

EXPIRED VACCINEEXPIRED VACCINE

POOR QUALITY VACCINEPOOR QUALITY VACCINE

Bacterialvaccines

Viralvaccines

8. Covexin* 8

9. Ultrabac® 8

4. Sheep pox

vaccine

Mixedvaccines

1. FMD vaccines

3. BEF Vaccine

5. PNEUMO 3

6. PNEUMO 4

2. RP Vaccine

1. BCG vaccine

2. HS Vaccines

3. Pneumo - Bac

4. Brucella Abortus

Strain 19 Vaccine

7. Brucella Melitensis

Vaccine Strain “REV. 1”

1. Entero – 3

Vaccine

7. CattleMaster4

8. Vira Shield 5

2. ScourGuard 3

6. Abortex

5. RB51 vaccine

1-Viral Vaccine

1-MD Vaccine

Monovalent Inactivated FMD Vaccine

(type O1/93 locally isolated in Egypt)

Protection of cattle, buffaloes,

sheep and goats against FMD

First dose:

- Cattle & buffaloes 3 months & older 2 ml

- Sheep & goats 1 ml

- Dairy cattle revaccinated every 4 months .

- Breeding calves sheep & goats revaccinated every 4-6 months.

PACKAGE: Each bottle Contains 300 ml

Second dose:

4 wks post 1st dose.

SC

1-

Bivalent Inactivated FMD Vaccine

(type O1/93 and type AEGY/06

locally isolated in Egypt)

Protection of cattle, buffaloes,

sheep and goats against FMD

First dose:

- Cattle & buffaloes 3 months & older 2 ml

- Sheep & goats 1 ml

- Dairy cattle revaccinated every 4 months .

- Breeding calves sheep & goats revaccinated every 4-6 months.

PACKAGE: Each bottle Contains 300 ml

Second dose:

4 wks post 1st dose.

SC

1-

:

The vaccine contains virus of FMD type O (1/93)

and type A (EGY/06).

It is locally isolated in Egypt.

It is inactivated by 2- bromoethylamine

hydrobromide (BEI).

Adjuvanated by aluminum hydroxide gel and

purified saponin.

COMPOSITION

INTERACTIONS:

Other vaccination programs

should be carried out at least two

weeks before or after FMD

vaccination.

PROPAGATION SYSTEM:

Baby hamster kidney monolayer cell

line (BHK).

INSTRUCTIONS FOR USE:

Shake the bottle before use.

the vaccine is inoculated subcutaneously in the dwelap

10-15 cm in front of the sternum.

In sheep and goats subcutaneously behind the shoulder

or in the middle of the lower side of the neck.

Press on the injection site for a while then make gentle

massage for a short time. The vaccine gives immunity for

6 months.

VACCINE REACTION

A painful swelling may be developed

within one or two days at the site of

injection .

It does not influence the general

condition of the animals.

This swelling subsides within 10 days.

No drop in milk production.

Aftovaxpur

- 2 ml Cattle

- 1ml Sheep

- 6 m

Inactivated polyvalent vaccine

(O1, A22, SAT2, ASIA1)

Type:

Dose:

- SC

- 300 ml 3500 LE

Route:

Duration of immunity: Price:

3-

2-Rinder PestVaccine

Attenuated T.C. Vaccine

(" RBOK " strain)

PACKAGE:

Available in vial of 50 or 100 doses.

Protection of cattle & buffalo

against Rinderpest

1ml

SC

Solid immunity last for

5 – 6 years

Dissolve the lyophilized material in 50

or 100 ml sterile chilled physiological

saline solution. Use it within one hour

Cell culture Rinderpest vaccine is an attenuated vaccine which

confers immunity for many years when inoculated at optimum

conditions. Vaccine is prepared according to FAO and OIE

instructions , by using the international reference

" RBOK " strain .

MODE OF USE:

-Dissolve the lyophilized material in 50 or 100 ml (according to the

dose) sterile chilled physiological saline solution. Use it within one

hour. -The dose (1ml contain at least 103 TCID50 ) is injected

subcutaneously. -Inoculate each animal with (1 ml ) of dissolved

vaccine subcutaneously using sterile syringe. -Separate, sterile

syringe is necessary for each animal.-Vaccine should be kept on

ice, away from sunlight throughout the time of use. -Don’t use

disinfectant, alcohol to sterile needles.-The vaccine is completely

safe for Pregnant animals within the previously mentioned dose.

Inactivated Vaccine

Protective of cattle & buffalos

against BEF

2ml

PACKAGE:

Each bottle contains

20 ml (10 doses).

SC

- Second dose ( booster dose) :

2ml after 4 weeks.

- The same program repeated

annually.

Animals must be

vaccinated before

summer season

COMPOSION:

Each dose contains at least 106.5 TCID50 of the virus.

PROPAGATION SYSTEM:

Green monkey kidney cell line ( VERO ).

VACCINATION PROGRAME:

- Animals of 6 months age vaccinated with the vaccine.

- First dose : 2ml injected (S/C ).

- Second dose ( booster dose) : 2ml injected S/C after 4 weeks.

- The same program repeated annually.

Inactivated Bovine Ephemeral Fever Vaccine

REMARKES:

- The vaccine is safe for pregnant and lactating animals.

- Animals must be vaccinated before summer season.

CONTRAINDICATION:

Animals clinically ill or those weakened should not be vaccinated.

4- Respiratory Virus Vaccine

IBR,BVD, PI- 3

& BRS

diseases

4-Types ofRespiratory Virus Vaccines

1-EgypianRespiratory Virus Vaccines

Combined Inactivated

Respiratory Virus Vaccine

Cattle & buffalo 5 ml

Sheep 3 ml

PACKAGE: bottle 100 ml (20 doses).

Protection of cattle,

buffaloe & sheep against

IBR, BVD, & PI- 3 diseases

IM

6 m

2nd dose 2 weeks apart

1

DESCRIPTION:

A combined inactivated vaccine used for protection of cattle,

buffaloe and sheep against IBR, BVD, & PI- 3 diseases.

"PNEUMO 3"

COMPOSITION:

- Each dose contains not less than:

- IBR 106 TCID50

- BVD 106 TCID50

- PI – 3 106 TCID50

- Adjuvants : aluminum hydroxid gel.

VACCINATION PROGRAMME:

- Animals vaccinated at ( 2 – 4 ) months old, 2nd dose must be given two

weeks after the 1 st dose . Then revaccination should be done every 6

months.

- Pregnant cow dames could be vaccinated with two doses, two months

before parturition with 2 weeks interval.

- Animals from non vaccinated dames could be vaccinated at age of 3-4

weeks.

PACKAGE:bottle of 100 ml (20 doses).

Combined Inactivated

Respiratory Virus Vaccine

Cattle & buffalo 5 ml

Sheep 3 ml

Protection of cattle, buffaloe

& sheep against IBR, BVD,

PI- 3 & BRS diseases

IM

6 m

2nd dose 2 weeks apart

2

" Pneumo 4"

DESCRIPTION:

A combined inactivated vaccine used for protection of cattle, Buffalo

and sheep against IBR, BVD, PI- 3 & BRS diseases.

COMPOSITION:

Each dose contains not less than:

IBR 106 TCID50

BVD 106 TCID50

PI – 3 106 TCID50

BRS 106 TCID50

Adjuvants : aluminum hydroxid gel.

VACCINATION PROGRAMME:

- Animals vaccinated at 2 – 4 months old, 2nd dose must be given two

weeks after the 1 st dose . Then revaccination should

be done every 6 months.

- Pregnant dams could be vaccinated with two doses, two months

before parturition with 2 weeks interval.

- Animals from non vaccinated dames could be vaccinated at age of 3- 4

weeks.

2-ForienRespiratory Virus Vaccines

Indications:For vaccination of healthy cattle,

including pregnant cows, as an aid in

preventing abortion caused by

infectious bovine rhinotracheitis (IBR,

bovine herpesvirus Type 1),

persistently infected calves caused by

bovine viral diarrhea (BVD) virus Types

1 and 2, respiratory disease caused by

IBR, BVD (Types 1 and 2),

parainfluenza3 (PI3 ) and bovine

respiratory syncytial virus (BRSV) and

leptospirosis caused by Leptospira

canicola, L. grippotyphosa, L. hardjo,

L. icterohaemorrhagiae and L. pomona.

CattleMaster® GOLD™ FP® 5 L5

1

Protection of cattle &

buffaloe against IBR,

BVD, PI- 3 & BRS

diseases

IM

2 ml

Combined vaccine

2nd dose 2 weeks apart

One year

Dosage and Administration

General Directions: Vaccination of healthy cattle is

recommended. Aseptically rehydrate the freeze-dried

vaccine with the liquid component provided, shake well

and administer 5 mL subcutaneously. In accordance with

Beef Quality Assurance guidelines, products should be

administered in the muscular region of the neck.

Primary Vaccination: Administer an initial 5-mL dose,

followed by a second 5-mL dose 3 weeks later. As an aid in

preventing IBR-induced abortion and BVD persistently

infected calves, administer at approximately 5 and 2 weeks

prior to breeding. Calves vaccinated before the age of 6

months should be revaccinated after 6 months of age.

Revaccination: Annual revaccination with a single dose is

recommended.

Good animal husbandry and herd health management

practices should be employed.

Protection of cattle

& buffaloe against

IBR, BVD (2 types)

, PI- 3 & BRS

diseases

IM or SC

5 ml

Combined

Inactivated

Vaccine

2nd dose 4 weeks apart

One year

2

5-Sheep Pox Vaccine

Protects sheep & goats against

pox disease, & cattle against LSD

I/D or S/C

0.5 ml

Live attenuated freeze dried

tissue culture vaccine

one year

PACKAGE:Each vial contains 100 dose.

Tissue Culture Sheep Pox Vaccine

COMPOSITION:

Each dose contains at least 102.5 TCID50.

PROPAGATION SYSTEM:

Green Monkey Kidney cell line ( Vero ).

DOSAGE:

- Reconstitute the vial contents in 50 ml physiological saline.

- Each dose is 0.5 ml injected interadermally (I/D) or subcutanously (S/C).

- Vaccination repeated annually.

REMARKS:

- The reconstituted vaccine should be used within two hours.

2-Bacterial Vaccine

1-BCG Vaccine

Strain called bacille Calmette &

Guerin

Developed by Albert Calmette &

Camille Guerin two french

investigors in 1920s

attenuated strain of M. bovis

0.5 cm for cow & buffalo male calves

0.1 cm for lambs

Intradermal

Once / life (solid immunity)

Freeze Dried B.C.G. Vaccine

the BCG was not an effective cattle vaccine

1. Used to protection of human and animals against tuberculosis

2. Give non-specific immunity to another diseases by

stimulation the immune system as:

a) Caseous lymphadenitis. b) Brucellosis.

c) Haemorrhagic septicemia. d) Listeria.

d) Staph. aureus. e) Strept. pyogens.

f) Salmonellosis. g) Pox

h) Rift Valley Fever

3. When used in fed lot animals increase the food conversion rate

Used in males onlydue to vaccinated animals persist to give tuberculin

test positive (false +ve) so, it interfere with test and slaughter program.

BCG Vaccine.COMPOSITION :

* Vial containing 5 mg of lyophilized vaccine.

* Vial containing 6 ml of diluent ( Sauton 1+ 3 )

INDICATIONS :

1) Provide non specific immunity against viral, bacterial and parasitic diseases.

2) Protect sheep from Pseudo tuberculosis, Pox and Rift Valley Fever.

3) Increase the immune efficacy and body weight gain of fattening calves.

DIRECTIONS AND DOSAGE:

The lyophilized vaccine is reconstituted with the diluent and injected I/D as follows

: AnimalDilution Dose Vacc. Conc. Site Cow - calves2.5 ml 0.5 ml1 mgUnder the tail. Buffaloe -

calf 2.5 ml0.5 ml1 mgSide of the neck Sheep 5 ml0.1 ml0.1 mgInner aspect of the thigh or under

the fatty tail.Lambs10 ml0.1 ml0.05 ml

PRECAUTIONS:

1) The vaccine should be used quickly as possible after reconstitution, and any remaining vaccine

should be discarded.

Un used diluted vaccine, empty vails and used syringes must be disposed hygienically. 2) Bulls,

cows and buffaloes never to be vaccinated .

3) Vaccination is stopped in cases of general weakness, serious skin diseases and acute illness (

fever )

STORAGE:

The vaccine should be stored in a dry place protected from direct sunlight or diffuse day light at a

temperature between 4 - 8oC, not freezer.

Validity :

Tow years from the manufacture date.

PACKAGE:

A vial containing 5 doses for calves or 50 doses for sheep.

2- Pasteurellosis Vaccine

Inactivated HS Oil Adjuvant

Vaccine (type B:6)

PACKAGE: bottle 300 ml. (150 dose).

Protection of cattle & sheep

against HS & pneumonic

pasteurellosis

2 ml in cattle

1 ml in sheep

IM

9 m

1

DESCRIPTION:Haemorrhagic septicaemia oil adjuvant is an inactivated oil emulsion vaccine used for active immunization of cattle against haemorrhagic septicaemia and pneumonic pasteurellosis.

COMPOSITION:Each dose of the vaccine contains pasteurella multocida type B:6 inactivated with formalin and emulsified in oil base.

VACCINATION PROGRAM:- In areas where the disease occur seasonaly animals should be vaccinated two or three weeks before the season.- Where the incidance is not seasonal, animals should be vaccinated every nine months.- When outbreaks of the disease occur, all contact stock must be vaccinated as soon as possible.

RECOMENDATIONS:- Shake the vaccine vigoursly before and during use to ensure good mixing.- Allow the vaccine to reach room temperature before vaccination. - Intravenous injection must be avoided. - Animals to be vaccinated should be in good health and not suffering from any disease.

Inactivated Oil Adjuvant

Polyvalent Pneumonic

Pasteurellosis Vaccine

Cattle and buffaloes:

Over 100kg 2ml

Under 100kg 1ml.

Sheep & goat : 1ml.

PACKAGE: bottles 300 ml. (150 dose for cattle, 300 dose for sheep & goat).

Protection of Cattle, Sheep & Goat

against pneumonic pasteurellosis.

2nd dose 4 weeks apart

One year

IM

2

Protects against H.S. in

horses, mules & donkeys

S/C

1 ml at 6th month

2 ml at 1 year

3 ml at 2 years

5 ml at 3 years

Formalized killed vaccine

6 months

3

DESCRIPTION:Pneumo - bac is an inactivated oil adjuvant polyvalent pasteurellosis vaccine used for active immunization of cattle, sheep and goat against pneumonic pasteurellosis.

COMPOSITION:The vaccine contains pasteurella multocida types A,B & D and pasteurella haemolytica types A & T inactivated with formalin and emulsified in oil base.

VACCINATION PROGRAM: - Animals vaccinated with two doses four weeks internal.- For pregnant animals, vaccination with two doses four weeks internals at 6-8 weeks before parturition.- Animals born from vaccinated dams should be vaccinated at 8 weeks of age. - Animals born from unvaccinated dams should be vaccinated at one week age.- Revaccination with one dose annually.

RECOMENDATIONS:- In areas where the disease occurs seasonally, animals should be vaccinated at 4 or 5 weeks before the season.- When outbreaks of the disease occur, all contact stock must be vaccinated as soon as possible.

3-Brucella Vaccine

PACKAGE:

Vials 10 ml contains 10 reduced doses of lyophilized vaccine

( 3-10 x 109 CFU / dose ( accompanied with 20 ml diluent.

Protection of cattle, buffaloes

against Brucellosis

Living attenuated smooth B.abortus strain 19 in

serous form or freeze dried (lyophilized vaccine).

SC to female calves between 4 to 8 months old

5 successive years

Full dose (standard dose): about 60 – 80 x109

microbial cells in about 2ml.

Reduced dose (1/20 of full dose): It is widely used

nowadays specially in un-affected herd and it is

characterized by rapid decline in aglutinins.

1

* Used in female calves at 4 – 8 months (average 6

months).

* Not used before 4 months of age due to:

(1) Reticulo-endothelial system is still undeveloped

so may result in low titer of antibodies (not

protect against disease).

(2) When given at this age, the colostrums

antibodies interfere the microbial dose and so

the immunity produce is low.

* Not used after 8 months of age: Animal produces

permanent agglutinin titer (permanent +ve

serological test).

* Disadvantage of this vaccine:

(1) Used to vaccination of female only due to it

produce orchitis in bull.

(2) Not use in adult female as it cause abortion

except it can use in adult female in case of

outbreak.

(3) Interfere with control program due to it give

serological +ve (5% of vaccinated animal give

resistant agglutinin for 2 – 3 years).

(4) Give infection and un-dutant fever to human.

(5) Not prevent complete infection from udder.

(6) It need to be refrigerated, problems of storage

and transport at 4oC.

COMPOSITION:

Each dose of reconstituted vaccine contains 3-10 x109

CFU of Brucella abortus Strain 19.

ADVERSE REACTIONS:

These occur rarely in both calves and adults , to be more

sever in foreign breeds.

A local swelling occurs particularly in adult cattle and

there may be a sever systemic reaction manifested by

fever lasting

for 2-3 days.

Anaphylactic shock may occur and immediate treatment

with adrenaline hydrochloride ( 1m1. of 1 : 1000 diluted

solution

injected subcutaneously ) or Antihistaminic drug, is also

recommended

Live attenuated vaccine of Brucella

abortus rough strain RB51

10 – 34 million bacteria/2ml as one

or 2 dose 30 day interval

Protection cattle, buffaloes & sheep

against brucellosis by B. abortus.

1 – 2 years and animals

vaccinated annually

SC

2

1. Not result in measurable Ab titers to B. abortus using

standard diagnostic tests so, not interference with

eradication program of Brucellosis using such test.

2. Eliminate costs associated with resting and trace backs

of false +ve reactors as in B. abortus st. 19 vaccine.

3. Not excrete in excretion and secretion of animals.

4. Used in all ages of the animals.

5. There is no any side effect on vaccinated animals.

6. Not protect animal infected with another species of

Brucella as Brucella melitensis

- Age: Female calves of 4 – 12 months.

- Adult non-pregnant female. (Cause abortion)

Advantages:

Brucella Melitensis Vaccine Strain “REV.

PACKAGE:

- Vials 10 ml contains 10 doses of lyophilized vaccine (1 to 2 x 109

CFU / dose ( accompanied with 20 ml diluent.

- Vials 10 ml cantains 5 doses of lyophilized vaccine ( 1- 2 x 109

CFU / dose( accompanied with 10 ml diluent.

INDICATIONS AND DOSAGE:

After reconstitution with the accompanied diluent, it should contain 1

to 2 x 109 CFU viable organisms per 2 ml dose, given

subcutaneous to lambs and kids aged between 3 to 8 months.

Vaccination is followed by the appearance of specific antibodies.

Do not vaccinate pregnant or lactating females two month prior to

meeting.

Living attenuated B. Melitensis vaccine

3

COMPOSITION:

Each dose of reconstituted vaccine contains 1 to

2 x 109 CFU of Brucella Melitensis “Strain Rev.

1.”ADVERSE REACTIONS:

These occur rarely in both young or adult.

A local swelling may occurs .

Severe systemic reaction manifested by fever lasting

for 2-3 days.

Allergic reaction may occur .

treatment with adrenaline or antihistaminic drugs

should be done.

3-Clostridial Vaccine

clostridial diseasesclostridial diseases

Lamb dysentery

Struck

Pulpy kidney

Braxy & Malignant oedema

Blackleg

Tetanus

Black disease

Bacillary haemoglobin urea

Cl. perfringens type B

Cl. perfringens type C

Cl. perfringens type D

Cl. novyi type B

Cl. septicum

Cl. chauvoei

Cl. novyi type D

Cl. tetani

caused by

ULTRABAC® 7

• ULTRABAC 7 provides effective,

protection against the following key

clostridial diseases:

• blackleg – Cl. chauvoei

• malignant edema – Cl. septicum

• black disease – Cl. novyi

• gas-gangrene – Cl. sordellii

• enterotoxemia, enteritis – Cl. perfringens

types B, C, and DPackaging:

10-, 50-, & 200-dose vials

Dosage & route:Shake well. Aseptically administer 5 mL

subcutaneously, followed by a second

dose 4–6 weeks later

Annual revaccination with a single dose is recommended

Indications:

1

Protects cattle, sheep & goat

against 8 clostridial diseases

S/C

Polyvalent formalized

killed vaccine

6 months

2nd dose

2 ml

5 ml

6 W1st dose

2 ml

5 ml

sheepcattle

2

Protects cattle, sheep & goat

against 8 clostridial diseases

S/C

Polyvalent formalized

killed vaccine

6 months

2nd dose

2 ml

5 ml

6 W1st dose

2 ml

5 ml

sheepcattle

3 Cubolac 8

United Biofarm

Protects cattle, sheep & goat

against 8 clostridial diseases

S/C

Polyvalent formalized

killed vaccine

6 months

2nd dose

2 ml

5 ml

6 W1st dose

2 ml

5 ml

sheepcattle

3-Covaccin 10

10

Protects sheep & goat against

8 clostridial diseases

S/C

1st dose

5 ml

Polyvalent formalized

killed vaccine

6 months

2nd dose

3 ml

6 W

4

3-Mixed Vaccine

Inactivated Bovine Rota, Corona

Viruses and E-Coli Vaccine

Protection of newly born calves

against diarrhoea caused by

Rota, Corona viruses and E-Coli

4 ml in pregnant cow or buffalo

PACKAGE:

bottles of 20, 40 and 100ml.

IM

2 doses at least two weeks apart to

pregnant cows, the second dose

given 2-3 weeks before calving.

One year

1

COMPOSITION:Each dose contains at least 106 TCID50 of each bovine Rota and Corona viruses and 6x1010 CFU of E - Coli k99 Pili.

VACCINATION PROGRAMME: - Two I/M doses at least two weeks apart to pregnant cows, the second dose given 2-3 weeks before calving. - Revaccination with a single third dose if cows have not calved within 40 days after

receiving their last dose.

Inactivated Bovine Rota, Corona

Viruses and E-Coli Vaccine

Protection of newly born calves

against diarrhoea caused by

Rota, Corona viruses and E-Coli

IM

2 doses at least two weeks apart to

pregnant cows, the second dose

given 2-3 weeks before calving.

2 ml in pregnant cow or buffalo

One year

2

Inactivated Bovine Rota, Corona

Viruses and E-Coli Vaccine

Protection of newly born calves

against diarrhoea caused by

Rota, Corona viruses and E-Coli

IM

2 ml at 160 days old

One year

3 Rota-vec Vaccine

Vaccination programmein

dairy farms

Vaccination programmein

dairy farms

Cow Herd VaccinesCow Herd Vaccines

Precalving Vaccination of Cows and Precalving Vaccination of Cows and HeifersHeifers

((7 7 to to 9 9 months of pregnancy or twice a year)months of pregnancy or twice a year)

1.1. 44--way Viral BRD Vaccineway Viral BRD Vaccine

2.2. Pasteurella Bacterin & LeukotoxoidPasteurella Bacterin & Leukotoxoid

3.3. Clostridia Bacterin & LeukotoxoidClostridia Bacterin & Leukotoxoid

4.4. Scour VaccineScour Vaccine

11--Lumpy Skin Disease Lumpy Skin Disease vaccinevaccine

First injection in FebruaryFirst injection in February

The second dose every yearThe second dose every year

22--FMD vaccineFMD vaccine

First injection in AprileFirst injection in Aprile

The second dose after The second dose after 2 2 weeksweeks

The next vaccine every The next vaccine every 4 4 monthsmonths

33--Rift valley vaccineRift valley vaccine

First injection in AprilFirst injection in April

The second dose in OctoberThe second dose in October

44--Respiratory virus Respiratory virus vaccinevaccine

Calves are vaccinated at Calves are vaccinated at 60 60 days @ days @ 180 180 daysdays

All animals are vaccinated annually in All animals are vaccinated annually in septemberseptember

55--Viral and bacterial diseases Viral and bacterial diseases causing diarrhea vaccinecausing diarrhea vaccine(Rota , corona @ E coli)(Rota , corona @ E coli)

All pregnant cows are vaccinated at All pregnant cows are vaccinated at 255 255 days of pregnancy.days of pregnancy.

The second booster dose at The second booster dose at 2 2 weeks weeks before parturitionbefore parturition

6-Brucellosisvaccine (every vaccine (every 3 3 years)years)

First injection in JanuaryFirst injection in January

The second dose every The second dose every 3 3 yearsyears

77--Clostredial Disease Clostredial Disease vaccinevaccine

First injection in calves at First injection in calves at 14 14 and and 42 42 days olddays old

The second dose every yearThe second dose every year

All pregnant cows are vaccinated All pregnant cows are vaccinated 2 2 weeks befor parturation .weeks befor parturation .

8-pasteurellosisvaccine (Annually)vaccine (Annually)

All pregnant cows are All pregnant cows are vaccinated at every year (in vaccinated at every year (in April month)April month)