utilizing nessi™ for analytical applications dave veltkamp, cpac new sampling/sensor initiative...

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Utilizing NeSSI™ for Utilizing NeSSI™ for Analytical Analytical Applications Applications Dave Veltkamp, CPAC Dave Veltkamp, CPAC Ne Ne w w S S ampling/ ampling/ S S ensor ensor I I nitiative ( nitiative ( NeSSI NeSSI ™) ™)

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Utilizing NeSSI™ for Utilizing NeSSI™ for Analytical ApplicationsAnalytical Applications

Dave Veltkamp, CPACDave Veltkamp, CPAC

NeNew w SSampling/ampling/SSensor ensor IInitiative (nitiative (NeSSINeSSI™)™)

Overview of TalkOverview of TalkDescribe the features of NeSSI™ most Describe the features of NeSSI™ most likely to impact lab applicationslikely to impact lab applications

Discuss how NeSSI™ can facilitate Discuss how NeSSI™ can facilitate laboratory applications and how laboratory applications and how current development fits lab needscurrent development fits lab needs

Outline some outside proposals Outline some outside proposals recently written to help fund NeSSI™ recently written to help fund NeSSI™ development & demonstration development & demonstration

Mention some web-based resources at Mention some web-based resources at CPACCPAC

What does NeSSI™ ProvideWhat does NeSSI™ ProvideSimple “Lego-like” assemblySimple “Lego-like” assembly

Easy to re-configureEasy to re-configureNo special tools or skills requiredNo special tools or skills required

Standardized flow componentsStandardized flow components““Mix-and-match” compatibility between vendorsMix-and-match” compatibility between vendorsGrowing list of componentsGrowing list of components

Standardized electrical and communication (soon)Standardized electrical and communication (soon)““Plug-and-play” integration of multiple devicesPlug-and-play” integration of multiple devicesSimplified interface for programmatic I/O and controlSimplified interface for programmatic I/O and control

Advanced analytics and measurement Advanced analytics and measurement environmentenvironment

Mini or Micro-analyzersMini or Micro-analyzersIntegrated analysis or “smart” systemsIntegrated analysis or “smart” systems

Expose students to “Industrial” techniques & Expose students to “Industrial” techniques & needsneeds

NeSSI™: Enabler for NeSSI™: Enabler for MicroAnalytical MicroAnalytical

(the “rail” concept)(the “rail” concept)

Standard Mechanical Interface “Rail”

Standard Electrical (Digital) Interface “Rail”

Anyone’s Sensor Anyone’s Actuator

SAM*

Standard “hockey-puck

PC”P

V

*Sensor/Actuator Manager

Standard“connectivity

How Does NeSSI™ Fit in the How Does NeSSI™ Fit in the LabLab

Instrument/Sensor InterfacesInstrument/Sensor InterfacesDesign standards make development simplerDesign standards make development simpler

Reduced toolset to be masteredReduced toolset to be mastered Reduced sample variability to account forReduced sample variability to account for

Calibration/validation built-inCalibration/validation built-in Consistent physical environment for measurementConsistent physical environment for measurement Stream switching and/or mixing allow generation of Stream switching and/or mixing allow generation of

standards to match analytical requirementsstandards to match analytical requirements

Reaction monitoringReaction monitoringMicroreactors and continuous flow reactorsMicroreactors and continuous flow reactorsBatch reactors (with fast loop)Batch reactors (with fast loop)

Sample PreparationSample PreparationGas handling (mixing, generation, delivery)Gas handling (mixing, generation, delivery)Liquid handling (mixing, dilution, conditioning, etc.)Liquid handling (mixing, dilution, conditioning, etc.)

Special Lab NeSSI™ Special Lab NeSSI™ RequirementsRequirements

Flowing streamsFlowing streamsNeed to move liquid and gas streams through Need to move liquid and gas streams through NeSSI™ NeSSI™ Most laboratory analysis involves discrete samples Most laboratory analysis involves discrete samples rather than sample streamsrather than sample streamsAnalytical characterization of flow in NeSSI™ Analytical characterization of flow in NeSSI™ neededneeded

Heating and CoolingHeating and CoolingLaboratory applications need bothLaboratory applications need bothMay require more rapid thermal responseMay require more rapid thermal response

Integration with other lab apparatusIntegration with other lab apparatusSerial communication most commonSerial communication most commonIntegration with lab software systemsIntegration with lab software systems

Low costLow costCompeting with other solutions that don’t carry Competing with other solutions that don’t carry some of NeSSI’s more exotic featuressome of NeSSI’s more exotic features

Recent proposals featuring Recent proposals featuring NeSSI™ NeSSI™

NSF Instrumentation for Materials NSF Instrumentation for Materials Research (IMR)Research (IMR)

Involves NeSSI™ and Microreactors to Involves NeSSI™ and Microreactors to elucidate reaction kinetics and mechanisms elucidate reaction kinetics and mechanisms for polymer modification chemistryfor polymer modification chemistry

Builds on previous CPAC concepts for Builds on previous CPAC concepts for NeSSI™ as fluidic delivery AND analysis NeSSI™ as fluidic delivery AND analysis platform for microreactorsplatform for microreactors

Includes development and testing of Includes development and testing of Synovec’s μ-MMS in NeSSI™ Synovec’s μ-MMS in NeSSI™

3 years, $718K 3 years, $718K

NeSSI™ Proposals (cont.)NeSSI™ Proposals (cont.)

NSF Chemistry Research NSF Chemistry Research Instrumentation and Facilities: Instrumentation and Facilities: Instrument Development (CRIF-ID)Instrument Development (CRIF-ID)

Provides basic research and testing to Provides basic research and testing to characterize NeSSI™ flows and develop characterize NeSSI™ flows and develop needed support sub-systems for utilizing needed support sub-systems for utilizing NeSSI™ in laboratory applicationsNeSSI™ in laboratory applications

Funding to develop 3 (gas, liquid, and Funding to develop 3 (gas, liquid, and student lab) demonstration NeSSI™ student lab) demonstration NeSSI™ systemssystems

3 years, $642K3 years, $642K

NeSSI™ Proposals (cont.)NeSSI™ Proposals (cont.)

NSF Sensors and Sensor NetworksNSF Sensors and Sensor NetworksInvolves using NeSSI™ as a platform for Involves using NeSSI™ as a platform for characterizing vapochromatic compounds characterizing vapochromatic compounds and development of gas phase sensorsand development of gas phase sensors2 identical NeSSI™ systems at UW and UM2 identical NeSSI™ systems at UW and UM3 years, $612K3 years, $612K

Washington Technology Center (WTC)Washington Technology Center (WTC)Development of prototype sensor/actuator Development of prototype sensor/actuator manager (SAM)manager (SAM)Collaborative effort with InfometrixCollaborative effort with InfometrixPhase I, 6 months, $40KPhase I, 6 months, $40K

NeSSI™ Fermentation NeSSI™ Fermentation SystemSystem

Switching filter system to handle Switching filter system to handle particulate laden liquid streamsparticulate laden liquid streams

Cells in fermentation brothCells in fermentation broth

Supplied by Bob Sherman, CircorSupplied by Bob Sherman, Circor

Interested in plugging, cleaning, and Interested in plugging, cleaning, and other issues related to bio/pharma other issues related to bio/pharma applicationsapplications

2 Filters

Circor FermI Filter SystemCircor FermI Filter System

Building Automated NeSSI™ Building Automated NeSSI™ Swagelok provided 5 pneumatic valves, Swagelok provided 5 pneumatic valves, flow components and pressure flow components and pressure transducerstransducersParker providing solenoid pilot valve Parker providing solenoid pilot valve manifold for actuating pneumatic valvesmanifold for actuating pneumatic valvesBrooks (Emerson) provided MFC’s and Brooks (Emerson) provided MFC’s and electronicselectronicsHoneywell providing funds for data I/O Honeywell providing funds for data I/O and control systemand control systemThanks to all these contributions, we are Thanks to all these contributions, we are very close to having an automated very close to having an automated NeSSI™ systemNeSSI™ system

Current CPAC NeSSI™ Current CPAC NeSSI™ systemsystem

NeSSINeSSI™™ Knowledge Network Knowledge Network

Main topic page divided into Main topic page divided into 4 sections4 sections

News and InformationNews and Information

Discussion (NeSSI Q&A)Discussion (NeSSI Q&A)

Component ListComponent List Only Manufacturers group may Only Manufacturers group may

post herepost here

Testing and ExamplesTesting and Examples

Main NeSSI™ web siteMain NeSSI™ web sitehttp://http://www.cpac.washington.edu/NeSSI.htmwww.cpac.washington.edu/NeSSI.htm

NKN can be found atNKN can be found athttp://http://www.cpac.washington.edu/NeSSI/NKN.htmlwww.cpac.washington.edu/NeSSI/NKN.html

Component List Sub-Component List Sub-topicstopics

Page shown from the “Valve, Manual” Page shown from the “Valve, Manual” topictopic

Listing of topics under manual valve main Listing of topics under manual valve main topictopic

Number of posts will correspond to Number of posts will correspond to different available componentsdifferent available components

Component List PageComponent List PageExample post Example post from the from the component component list pagelist page

URL from URL from VendorVendorSpec. sheet Spec. sheet or linkor linkPicture, Picture, description, or description, or link to more link to more informationinformation

Other Vendors are Other Vendors are currently working to currently working to populate the list with populate the list with more componentsmore components

Component List PageComponent List Page

User Self-RegistrationUser Self-Registration

Allows users to setup accountsAllows users to setup accountsSelecting to join “Manufacturers” Selecting to join “Manufacturers” group will queue user’s group will queue user’s registration until a moderator registration until a moderator approves it.approves it.Membership in other groups Membership in other groups automatically approved automatically approved immediately immediately

Profile data will be used for Profile data will be used for NeSSI™ mailing listNeSSI™ mailing list

Check the options available from Check the options available from the “Edit Profile” link once user the “Edit Profile” link once user activates accountactivates account

Once user submits registration Once user submits registration form, they are sent an email with form, they are sent an email with instructions for activating their instructions for activating their new accountnew account

Your account is not active till you Your account is not active till you log in and follow the instructions log in and follow the instructions in the emailin the email

NKN ConclusionNKN Conclusion

New software and web site ready to be usedNew software and web site ready to be usedThanks to Michelle Cohn, UOP for helping CPAC Thanks to Michelle Cohn, UOP for helping CPAC buy a new server to host NeSSI™ and NKN web buy a new server to host NeSSI™ and NKN web sitessites

Site functions well on the new server – much Site functions well on the new server – much easier to use for both posting and browsingeasier to use for both posting and browsing

NeSSI Component List is becoming NeSSI Component List is becoming populatedpopulated

Major manufacturers (Parker, Circor, Swagelok) Major manufacturers (Parker, Circor, Swagelok) already signed up and starting to supply contentalready signed up and starting to supply content

Still need to get smaller suppliers to do the sameStill need to get smaller suppliers to do the same

Need to get user community to register and Need to get user community to register and start using itstart using it

NeSSI™ Sensor SurveyNeSSI™ Sensor Survey

The purpose of this survey is to gather The purpose of this survey is to gather information on the sensors and information on the sensors and actuators needed for NeSSI Sample actuators needed for NeSSI Sample Systems, Analytical Systems, and Systems, Analytical Systems, and Cluster Applications.  Cluster Applications. 

This data will be shared with sensor and This data will be shared with sensor and instrument vendors to help them prioritize instrument vendors to help them prioritize development of the devices needed across development of the devices needed across industries and applications.  industries and applications.  The more information you can provide, the The more information you can provide, the faster better products and performance faster better products and performance can be delivered can be delivered

NeSSI™ Sensor Survey NeSSI™ Sensor Survey (cont.)(cont.)

On-line survey form on the CPAC NeSSI™ On-line survey form on the CPAC NeSSI™ web siteweb site

http://www.cpac.washington.edu/NeSSI/CPAC_Nehttp://www.cpac.washington.edu/NeSSI/CPAC_NeSSI_Sensor_Survey.htmSSI_Sensor_Survey.htm

Questions about condition sensorsQuestions about condition sensorsAre you interestedAre you interestedHow would you rank their importanceHow would you rank their importanceOperating rangesOperating ranges

Questions about analytical sensorsQuestions about analytical sensorsAre you interestedAre you interestedHow would you rank their importanceHow would you rank their importanceOperating rangesOperating ranges

Questions about actuatorsQuestions about actuatorsQuestions about “Clusters”Questions about “Clusters”Optional contact informationOptional contact information

Sample Survey QuestionsSample Survey Questions

NeSSI™ Sensor Survey NeSSI™ Sensor Survey ResultsResults

Condition SensorsCondition Sensors

Analytical SensorsAnalytical Sensors

Count Mean Rank Median RankPressure 18 3.8 44Temp 18 3.7 3.5Flow 19 3.9 4Humidity 16 3.0 3Cond. 12 2.6 3Other 8 2.9 3Combined 16 3.5 3

O2 NOx pH H2 CO CO2 Raman NIRCount 17 10 14 14 12 11 11 14

Mean Rank 3.7 3.2 3.0 3.3 3.1 3.1 3.0 3.2Med Rank 4 3 3 3 3 3 3 3

MIR UV/Vis NMR MS GC LC ViscosityCount 14 13 6 10 16 5 11

Mean Rank 3.2 3.1 2.9 3.2 3.9 3.0 2.9Med Rank 3 3 3 3 4 3 3

NeSSI™ Sensor Survey NeSSI™ Sensor Survey ResultsResults

ActuatorsActuators

ClustersClusters

14 of the 21 respondents indicated they 14 of the 21 respondents indicated they would share information with Vendorswould share information with Vendors

Count Mean Rank Median RankOn/Off Valve 18 3.7 4 Ball 8 Diaphragm 6Modulator Valve 14 3.3 3Solenoid Valve 15 3.2 3MFC 16 3.6 3VFC 14 3.4 3

CountCEMS 13Clean Water 11Waste Water 9HRVOC 8

NeSSI™ Sensor Survey NeSSI™ Sensor Survey (cont.)(cont.)

Plan is to continue to solicit responses from Plan is to continue to solicit responses from usersusers

Additions to survey questions or content welcomeAdditions to survey questions or content welcomeMay expand survey activities to help provide May expand survey activities to help provide market directions to suppliersmarket directions to suppliers

Other aspects of NeSSI™ developmentOther aspects of NeSSI™ development Applet Software and other issues relate to SAMApplet Software and other issues relate to SAM New opportunities or innovationsNew opportunities or innovations

Need to reach beyond the normal NeSSI™ Need to reach beyond the normal NeSSI™ enthusiastsenthusiasts

Combined with the discussion board, surveys Combined with the discussion board, surveys provide a valuable resource for both end-users provide a valuable resource for both end-users and manufacturers of NeSSIand manufacturers of NeSSI

Summary & ConclusionSummary & Conclusion

Automated NeSSI™ ready for developmentAutomated NeSSI™ ready for developmentWorking spec/prototype design completeWorking spec/prototype design completePrototypes demonstrated in real applicationsPrototypes demonstrated in real applicationsResolution of the NeSSI™ bus issueResolution of the NeSSI™ bus issue

For some laboratory applicationsFor some laboratory applicationsComponents and systems currently available Components and systems currently available will immediately work and provide benefitswill immediately work and provide benefits

For other applicationsFor other applicationsNew components/architecture will be needed New components/architecture will be needed to “fit” current lab practicesto “fit” current lab practices

The future holds a lot of promise!!The future holds a lot of promise!!