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Using Ventilator Waveforms to Optimize Patient – Ventilator Synchrony Nuala Meyer, MD MS

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Page 1: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Using Ventilator Waveforms to Optimize Patient – Ventilator Synchrony

Nuala Meyer, MD MS

Page 2: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Goals of the Talk• Recognize the different types of

ventilator asynchrony• Anticipate clinical scenarios for which

asynchrony is common• Tools to optimize conventional modes

of ventilation– Pressure Support– Volume Control– Pressure Control

Page 3: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Types of Asynchrony

1. Auto-triggering2. Ineffective Triggering3. Double triggering4. Premature Cycle5. Delayed Cycle

Thille AW Intensive Care Med 2006; Colombo D Crit Care Med 2011; Pohlman MC Crit Care Med 2008

Page 4: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Types of Asynchrony

1. Auto-triggering2. Ineffective Triggering3. Double triggering4. Premature Cycle5. Delayed Cycle

• Common: 24 – 80% of ventilated patients

• Asynchronies are frequently undetected– Even by ICU

Attendings• Increases energy

expenditure, may exacerbate weakness

Thille AW Intensive Care Med 2006; Colombo D Crit Care Med 2011; Pohlman MC Crit Care Med 2008

Page 5: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Types of Asynchrony

1. Auto-triggering2. Ineffective Triggering3. Double triggering4. Premature Cycle5. Delayed Cycle

• Common: 24 – 80% of ventilated patients

• Asynchronies are frequently undetected– Even by ICU

Attendings• Increases energy

expenditure, may exacerbate weakness

Thille AW Intensive Care Med 2006; Colombo D Crit Care Med 2011; Pohlman MC Crit Care Med 2008

Page 6: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Meyer NJ and Kress JP Chest 2006

Page 7: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Meyer NJ and Kress JP Chest 2006

Auto-Triggering in a man with C3 spinal level• Sawtooth, oscillating flow in expiratory waveform• Frequent culprits: excess moisture, nebulized medication, in-line suction device, cuff leak, cardiac oscillations

Page 8: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Meyer NJ and Kress JP Chest 2006

Auto-Triggering in a man with C3 spinal level• Sawtooth, oscillating flow in expiratory waveform• Frequent culprits: excess moisture, nebulized medication, in-line suction device, cuff leak, cardiac oscillations

Page 9: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Ineffective Triggering

• Ventilator detects patient effort as flow or pressure at the interface – Flow trigger is more sensitive than

pressure*– Increasing the flow threshold will ↑

ineffective breaths• Common for patients with COPD, iPEEP

– Correlates with higher levels of Pressure Support

Page 10: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Ineffective Triggering

Thille AW Intensive Care Med 2008

FLOW (L/s)

AirwayPressure (cm H2O)

Page 11: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Ineffective Triggering

Thille AW Intensive Care Med 2008

iPEEP

FLOW (L/s)

AirwayPressure (cm H2O)

Page 12: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Change in slope at end-exhalation:

Page 13: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Change in slope at end-exhalation:

Page 14: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Change in slope at end-exhalation:

Page 15: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Change in slope at end-exhalation:

Page 16: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Change in slope at end-exhalation:

Page 17: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Change in slope at end-exhalation:

Page 18: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Change in slope at end-exhalation:

Page 19: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Match ePEEP to iPEEP• Waterfall Analogy:

– Tobin MJ et al• Applying ePEEP has

little effect on upstream pressure until it equals / surpasses iPEEP

• Allows ventilator to detect “standard” trigger effort

iPEEP ePEEP

Martin MJ; Principles and Practice of Mechanical Ventilation, 2nd Ed

Page 20: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Match ePEEP to iPEEP• Waterfall Analogy:

– Tobin MJ et al• Applying ePEEP has

little effect on upstream pressure until it equals / surpasses iPEEP

• Allows ventilator to detect “standard” trigger effort

iPEEP ePEEP

Martin MJ; Principles and Practice of Mechanical Ventilation, 2nd Ed

Page 21: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Matching ePEEP to iPEEP

Page 22: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Matching ePEEP to iPEEP

Page 23: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Matching ePEEP to iPEEP

Page 24: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Double Trigger (Breath Stacking)

Pohlman MC Critical Care Med 2008

Page 25: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Optimizing Pressure Support

FLOW

PRESSURE

Page 26: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

• Control of Inspiration : Expiration varies by ventilator – Flow Cycle: cycle off at a % of Peak flow

• E-cycle, E-sensitivity– 25% of Peak (Inspiratory) Flow is Default

PSV: How is Inspiration Ended?

PIP

Hess D Respir Care 2005

Page 27: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

25% Flow Cycle: a Poor Fit

Page 28: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

• Emphysema: loss of elastic recoil – Peak flow is low, and high compliance

doesn’t limit inspiratory flow– Need to cycle off sooner flow cycle

~40%• Low compliance: IPF, ARDS

– Stiff lungs achieve a high peak flow very early

– Rapid decrement in flow results in short, small Vt

25% Flow Cycle: a Poor Fit

Page 29: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Airflow Obstruction and Flow Cycle

Page 30: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Airflow Obstruction and Flow Cycle

2550

Page 31: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Airflow Obstruction and Flow Cycle

2550

PRESSURE

FLOW

Page 32: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Airflow Obstruction and Flow Cycle

2550

PRESSURE

FLOW

Actively interrupt flow to trigger exhalation

Page 33: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory
Page 34: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Low Compliance: Turn Down Flow Cycle

Page 35: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Volume Control

Page 36: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Volume Control

Page 37: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Goal is to Match Flow:Patient

RR 32VE 17.5 L/min

Page 38: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Goal is to Match Flow:Patient

RR 32VE 17.5 L/min

Page 39: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Goal is to Match Flow:Patient

.

Options• Tolerate it • Find/Fix Why VE So High •Sedate +/- Paralyze•Set Higher flow rate• Change to square • Increase RR in effort to “overdrive” ventilation• Change to PC • Change to PRVC / VC

Page 40: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Goal is to Match Flow:Patient

.

Options• Tolerate it • Find/Fix Why VE So High •Sedate +/- Paralyze•Set Higher flow rate• Change to square • Increase RR in effort to “overdrive” ventilation• Change to PC • Change to PRVC / VC

Page 41: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Pressure Control: Optimize I-Time

Page 42: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Pressure Control: Optimize I-Time

• Difficult to predict neural I-Time

• Best done at the bedside

• Match I-time to Zero Flow– Unless attempting IRV

• Too Long– Inspiratory Pause

• Too Short– Risk Double Triggers– Inefficient pattern

Page 43: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Pressure Control: Optimize I-Time

• Difficult to predict neural I-Time

• Best done at the bedside

• Match I-time to Zero Flow– Unless attempting IRV

• Too Long– Inspiratory Pause

• Too Short– Risk Double Triggers– Inefficient pattern

Page 44: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory
Page 45: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

I-time TOO LONG

Page 46: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory
Page 47: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

I-time TOO SHORT(RR ↑ 32)

Page 48: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Just Right

Page 49: Using Ventilator Waveforms to Optimize Patient - Home ......Meyer NJ and Kress JP Chest 2006 Auto-Triggering in a man with C3 spinal level • Sawtooth, oscillating flow in expiratory

Thank You!