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USEFUL INFORMATION ON DISINFECTANTS AFTER CONTAMINATION WITH NOVEL SWINE ENTERIC CORONAVIRUS DISEASES (SECD)
NOVEMBRER 20, 2014
TABLE OF CONTENTS
PAGES
Recommendation on Disinfectants ..................................................................................... 1
Use of Disinfectants in winter .......................................................................................... 2
Propylene Glycol .............................................................................................................. 3
Summary Table of Useful information on Disinfectants.................................................. 4
Use Protocol when Combined with Propylene Glycol ..................................................... 6
Product Sheets ..................................................................................................................... 7
1 Stroke Environ ............................................................................................................... 8
Bioxy Enviro ...................................................................................................................... 9
Boost 1000 & Boost 1001 ............................................................................................... 11
Clorox Clean-Up Disinfectant Bleach Cleaner ................................................................ 13
Multi-Phenolique Disinfectant ....................................................................................... 15
PF 300 ............................................................................................................................. 16
Prevention Concentration .............................................................................................. 17
Synergize ........................................................................................................................ 18
Tek-Trol .......................................................................................................................... 19
Thymox ........................................................................................................................... 20
Virkon ............................................................................................................................. 22
Virocid ............................................................................................................................ 23
VirStop ............................................................................................................................ 25
Useful information on disinfectants after contamination with SECD | November 2014 1
Recommendation on Disinfectants For a disinfectant to be effective, surfaces must be thoroughly cleaned to remove all traces of organic matter.
Many virucidal disinfectants have been shown to be effective in inactivating porcine epidemic diarrhea virus (PEDV) and swine delta coronavirus (SDCV) which are novel swine enteric coronavirus diseases (SECD). One-Stroke Environ (Phenol), Virkon, Virocid, Synergize (quaternary ammonium and glutaraldehyde) and Clorox are examples of such disinfectants1. Other similar products may well be added to this list in the coming months. In this document, each proposed disinfectant has been shown to be effective against PEDV by the manufacturer. In some cases, this effectiveness has been estimated in function of that established against similar viruses (Transmittable Gastroenteritis or TGE, human coronavirus, etc.), while in other cases, it has been tested by an independent laboratory, and the report or the test results have been sent to us.
When used outdoors (e.g.: in a garden sprayer), disinfectant solutions must be regularly changed to remain effective. Ask your supplier what the manufacturer’s recommendations are in this regard. For example, a Virkon solution must be changed as soon as the pink colour indicator disappears and the solution becomes whitish, or after a maximum of 7 days, while a Virocid solution remains effective for up to 4 weeks. The solution must always be protected from sunlight and extreme temperatures.
A particularity of PEDV is its resistance to heat. It can resist heat for more than 3 hours at 50°C, but not at 60°C. Exposure for 10 minutes at 80°C is enough to inactivate the virus through heat. In comparison, Transmittable Gastroenteritis (TGE, a very similar virus) is inactive after exposure for 1 hour at 37°C.
This document is divided into three major sections. The first section, entitled “Summary Table of Useful Information on Disinfectants”, presents the contact information of distributors for each proposed disinfectant, the dilution rate recommended by the manufacturer, the contact time and, where available, information on its use below the freezing point when combined with propylene glycol. The second section, entitled “Use Protocol when Combined with Propylene Glycol” presents dilution tables for using disinfectants combined with propylene glycol. These tables are generic and may be used with any disinfectant shown to be compatible with propylene glycol, with the desired dilution rate. The third and final section, entitled “Product Sheets”, presents key information on each proposed disinfectant.
1 The following is only a proposal. The EQSP never recommends the use of any product. The EQSP recommends
that users contact their supplier to verify the recommended effectiveness, usage and contact time of products.
Useful information on disinfectants after contamination with SECD | November 2014 2
Use of Disinfectants in winter The “Use Protocol when Combined with Propylene Glycol” section presents useful dilution tables for cases when disinfectants are used in temperatures below the freezing point (0°C).
To use these tables, you must first consult the “Summary Table of Useful information on Disinfectants”, or the sheet of the product used to ensure that it is compatible when combined with propylene glycol. If the chosen disinfectant is compatible, you must choose the table corresponding to the dilution rate of the desired disinfectant and identify the percentage of the propylene glycol to obtain (based on room temperature and, as the case may be, the maximum percentage of propylene glycol recognized by the manufacturer). You will thus obtain three types of data, i.e. the volume or weight of the disinfectant, water and propylene glycol that must be used to produce 1 litre of disinfectant solution. This data can be multiplied to obtain the desired quantity of disinfectant solution.
Example:
1. Disinfectant liquid: For Synergize, at a temperature of -4°C, the manufacturer recommends a 0.8% dilution rate with a maximum of 10% of propylene glycol. The table available in the “Use Protocol when Combined with Propylene Glycol” section indicates the following three pieces of information for a 1% (1:100) dilution rate: 8 ml of Synergize, 892 ml of water and 100 ml of propylene glycol. To obtain 100 litres of solution, these amounts would thus be multiplied by 100, resulting in 800 ml of Synergize, 89.2 litres of water and 10 litres of propylene glycol.
2. Disinfectant powder: For Virkon at a temperature of -7°C, the manufacturer recommends a 1% dilution rate with a maximum of 20% of propylene glycol. The table available in the “Use Protocol when Combined with Propylene Glycol” section indicates the following three pieces of information for a 1% (1:100) dilution rate: 10 g of Virkon, 790 ml of water and 200 ml of propylene glycol. To obtain 100 litres of solution, these amounts would thus be multiplied by 100, resulting in 1 kg of Virkon, 79 litres of water and 20 litres of propylene glycol.
Useful information on disinfectants after contamination with SECD | November 2014 3
Important notes: 1. When mixing, use the following procedure, as the case may be:
a. Disinfectant liquid: always dilute the propylene glycol in water before adding the disinfectant at the required rate.
b. Disinfectant powder: always dilute the disinfectant in water before adding the propylene glycol to ensure the product is thoroughly diluted.
2. For some products, the manufacturer does not recommend using a concentration of propylene glycol above a certain level. In this case, the information is provided in the “Summary Table of Useful Information on Disinfectants” and in the product sheet. A higher concentration of propylene glycol could destabilize the solution prepared.
3. Propylene glycol increases the viscosity of solutions and some types of pumps may not be able to pump more viscous solutions as well.
4. Propylene glycol does not necessarily keep disinfectant solutions from freezing at very low temperatures (as the required concentration of propylene glycol then becomes very high) or if solutions are kept at below freezing temperatures for long periods. The following additional measures may be used to keep disinfectant solutions from freezing:
a. Store sprayers in heated buildings; b. Use sprayers that can heat the disinfectant solution; c. Use a portable heater to heat up the sprayer; d. Maintain a constant flow of the disinfectant solution in the pump.
Propylene Glycol For the above-described solutions, use pure USP or food grade propylene glycol. Propylene glycol improves fogging by fragmenting the solution drops into smaller particles, allowing for a better distribution and coverage of the sprayed surface. Propylene glycol is water-soluble and is safe for humans. It is also biodegradable. In the United States, propylene glycol is on the list of GRAS (Generally Recognized as Safe) products as an emulsifier and common food additive.
Note: Never use antifreeze for cars nor glycol ethylene, a product known to be toxic to humans and animals.
Useful information on disinfectants after contamination with SECD | November 2014 4
Summary Table of Useful information on Disinfectants Disinfectant
product Name of
distributor Address Resource-
person Telecommunications Email Active ingredient(s) Dilution rate
recommended by the manufacturer
Contact time
Protocol when
combined with
propylene glycol
1 Stroke Environ
Steris Canada Inc.
375, Britannia Road East, Unit 2 Mississauga, ON
Sylvain Simard
Tel.:1 800 444-9009, ext. 76011 Cell: 514 567-8127 Fax: (440) 350-7077
[email protected] Chlorophene 8.5% 0.4% 10 min. N/A
O-phenylphenol 10%
P-tert-pentylphenol 2%
Bioxy Enviro
Atomes Bio 3485 Ashby Ville Saint-Laurent, QC
Alain Brunet Tel.: 514 830-9447
[email protected] Sodium Carbonate Peroxyhydrate 30-70% 1% (10g/L) 15 min. 20% of PG recommend-ded
Alkyl (68% C12, 32% C14) dimethyl ethylbenzyl ammonium chloride
2%
Alkyl dimethyl benzyl ammonium chloride (C12-18)
2%
Boost 1000 & Boost 1001
Ecolab Canada 2222 Dagenais Ouest, Suite #201 Laval, QC
Éric Chatigny Tel.: 514 781-2622 Fax: 450 963-5256
[email protected] BOOST 1000 10% (reconstitution of
the disinfectant by mixing 50% of
1000 with 50% of 1001)
20 min. N/A C14 60%, C16 30%, C12 5%, C18 5% C12 68%, C14 32% Hydrogen peroxide
BOOST 1001 Potassium carbonate Sodium carbonate Tetrasodium EDTA
Clorox Groupe Xtreme
3165 De Miniac Saint-Laurent, QC
Martin Lavigne
Cell: 613 859-9334 [email protected] Sodium hypochlorite 1.84% 3% 10 min. Do not combine
Gluquat 2 West Penetone
10 900, rue Sécant Montréal, QC
Alexandre Marenger
Tel.: 514 355-4660, ext. 3025 Cell: 514 248-6061 Fax: 514 355-2319
[email protected] Benzalkonium chloride 8% 0.4% 10 min. N/A Didecyldimethylammonium chloride 3% Dioctyl dimethyl ammonium chloride 3% Octyl decyl dimethyl ammonium chloride 6% Glutaral 7.5%
Multi-Phénolique
Bio Agri Mix LP 226, avenue Drouin Sainte-Marie, QC
Jean-Noël Côté
Tel.: 418 386-1745 Cell: 418 570-9373 Fax: 418 386-1746
[email protected] Chlorophene 8.5% 1-2% N/A O-phenylphenol 10% P-tert-pentylphenol 2%
Useful information on disinfectants after contamination with SECD | November 2014 5
Disinfectant product
Name of distributor
Address Resource-person
Telecommunications Email Active ingredient(s) Dilution rate recommended by the manufacturer
Contact time
Protocol when
combined with
propylene glycol
PF 300 Bio Agri Mix LP
11 Ellens Street Mitchell, ON
Jean-Noël Côté
Tel.: 418 386-1745 Cell: 418 570-9373 Fax: 418 386-1746
Didecyldimethylammonium chloride 6.72% 1%-2%1 See prot. (max. of 60% of PG)
Glutaral 12.5%
Prevention Concentration
Farm Guard Products
36881 Dungannon Road Dungannon, ON
Mark Beaven Tel.: 519 529-3586 Cell: 519 955-7725
[email protected] Hydrogen peroxide 7% 2.5% 5 min. N/A
Synergize S.E.C. Repro 86, rue Roy Ange Gardien, De Rouville, QC
Louis Bonneville
Tel.: 1 888 446-4647 Fax: 450 293-0157
[email protected] Benzalkonium chloride 26% 0.8%
5 à 12 min.
See prot. (max. 10% of PG) Glutaral 7%
Tek-Trol S.E.C. Repro 86, rue Roy Ange Gardien, De Rouville, QC
Louis Bonneville
Tel.: 1 888 446-4647 Fax: 450 293-0157
Chlorophene 10.8% 0.4% 10 min. N/A
O-phenylphenol 12.1%
P-tert-pentylphenol 4.1%
Thymox Syrvet Canada 207A, des Alouettes St-Alphonse-De-Granby, QC
Réal Sauvage Tel.:1 888 779-7838 Fax: 450 361-1505
Thymol 23% 1% 1 min. (see sheet)
30% of PG recommend-ded
Virkon Vétoquinol Canada inc.
2000, chemin Georges Lavaltrie, QC
Marc Lalonde Tel.:1 800 363-1700 Cell: 514 714-8398 Fax: 1 888 714-8386
[email protected] Potassium peroxymonosulfate 21.4% 1%-5%2 10 min. See prot. (max. 20% of PG)
Virocid Merial Canada Inc.
20000, Clark Graham Baie d’Urfé, QC
Dominique Brault
Tel.: 514 457-1555 Cell: 819 817-8383 Fax: 819 394-3002
[email protected] Benzalkonium chloride 17% 0.25% - min. 1%3 10 min. See prot. (max. of 60% of PG)
Didecyldimethylammonium chloride 7.8% Glutaral 10.7%
VirStop Constant America
7585, rue Cordner LaSalle, QC
Denis Fortin Tel.: 514 761-3339, ext. 345 Cell: 514 609-6413
[email protected] Alkyldimethylbenzylammonium chloride 3-7% 0.5%-1.0% 10 min. N/A Octyldecyldimethylammonium chloride 3-7% Dimethyldioctylammonium chloride 1-5% Didecyl dimethyl ammonium chloride 1-5% Glutaraldehyde 5-10% Ethanol 1-5%
1 Truck (1%) and unloading dock (2%). 2 Disinfection at 1%, spraying (0.25L/m2 (or 10pi2)) at 1% or fogging (1-4L/100m3 (or 3500pi3) at 1%-5%. 3 Cleaning, disinfection and sanitizing (1L/10m2) at 0.25-0.5%, disinfection of transport equipment at 0.5-1%, vehicle tire wash at 1% and foot wash at a minimum of 1%.
Useful information on disinfectants after contamination with SECD | November 2014 6
Use Protocol when Combined with Propylene Glycol Follow the dilution rate recommended by the manufacturer or your veterinarian and the maximum rate of propylene glycol, where applicable.
For a 0.25% (1:400) dilution rate For a 0.4% (1:256) dilution rate 1L of 0.25% disinfectant solution and propylene glycol 1L of 0.4% disinfectant solution and propylene glycol
2.5 ml (or g) of disinfectant
Water volume(ml) Propylene glycol volume(ml)
Freezing point
4 ml (or g) of disinfectant
Water volume(ml) Propylene glycol volume(ml)
Freezing point °C °F °C °F
972.5 25 (2.5%) 0 32 971 25 (2.5%) 0 32 947.5 50 (5%) -2 28 946 50 (5%) -2 28 897.5 100 (10%) -4 25 896 100 (10%) -4 25 797.5 200 (20%) -7 20 796 200 (20%) -7 20 697.5 300 (30%) -12 10 696 300 (30%) -12 10 597.5 400 (40%) -21 -5 596 400 (40%) -21 -5
For a 0.8% (1:128) dilution rate For a 1.0% (1:100) dilution rate 1L of 0.8% disinfectant solution and propylene glycol 1L of 1.0% disinfectant solution and propylene glycol
8 ml (or g) of disinfectant
Water volume(ml) Propylene glycol volume(ml)
Freezing point
10 ml (or g) of disinfectant
Water volume(ml) Propylene glycol volume(ml)
Freezing point °C °F °C °F
967 25 (2.5%) 0 32 965 25 (2.5%) 0 32 942 50 (5%) -2 28 940 50 (5%) -2 28 892 100 (10%) -4 25 890 100 (10%) -4 25 792 200 (20%) -7 20 790 200 (20%) -7 20 692 300 (30%) -12 10 690 300 (30%) -12 10 592 400 (40%) -21 -5 590 400 (40%) -21 -5
For a 2.0% (1:50) dilution rate For a 2.5% (1:40) dilution rate 1L of 2.0% disinfectant solution and propylene glycol 1L of 2.5% disinfectant solution and propylene glycol
20 ml (or g) of disinfectant
Water volume(ml) Propylene glycol volume(ml)
Freezing point
25 ml (or g) of disinfectant
Water volume(ml) Propylene glycol volume(ml)
Freezing point °C °F °C °F
955 25 (2.5%) 0 32 950 25 (2.5%) 0 32 930 50 (5%) -2 28 925 50 (5%) -2 28 880 100 (10%) -4 25 875 100 (10%) -4 25 780 200 (20%) -7 20 775 200 (20%) -7 20 680 300 (30%) -12 10 675 300 (30%) -12 10 580 400 (40%) -21 -5 575 400 (40%) -21 -5
For a 3.0% (1:33) dilution rate For a 5.0% (1:20) dilution rate 1L of 3.0% disinfectant solution and propylene glycol 1L of 5.0% disinfectant solution and propylene glycol
30 ml (or g) of disinfectant
Water volume(ml) Propylene glycol volume(ml)
Freezing point
50 ml (or g) of disinfectant
Water volume(ml) Propylene glycol volume(ml)
Freezing point °C °F °C °F
945 25 (2.5%) 0 32 925 25 (2.5%) 0 32 920 50 (5%) -2 28 900 50 (5%) -2 28 870 100 (10%) -4 25 850 100 (10%) -4 25 770 200 (20%) -7 20 750 200 (20%) -7 20 670 300 (30%) -12 10 650 300 (30%) -12 10 570 400 (40%) -21 -5 550 400 (40%) -21 -5
Useful information on disinfectants after contamination with SECD | November 2014 7
Product Sheets
Useful information on disinfectants after contamination with SECD | November 2014 8
Name of product: 1 Stroke Environ DIN: 00611433
Manufacturer: Steris Corporation 5960 Heisley Road Mentor OHIO 44060
Website: www.sterislifesciences.com
Distributor: Steris Canada Inc. 375, Britannia Road East, Unit 2 Mississauga ON L4Z 3E2
Contact person: Sylvain Simard Tel.: 1 800 444-9009 Ext. 76011 Cell: 514 567-8127 Fax: 440 350-7077 Email: [email protected] Website: www.sterislifesciences.com Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes: References: HOFMANN M, and R. WYLER (1989). ”Quantitation, biological and
physicochemical properties of cell culture-adapted porcine epidemic diarrhea coronavirus (PEDV)”, Vet Microbiol, Jun; 20(2), p. 131-142.
POSPISCHIL A, STUEDLI A, KIUPEL M, et al (2002). ”Update on porcine epidemic diarrhea”, J Swine Health Prod. Vol. 10(2), p. 81-85.
SIMARD, Sylvain (June19, 2014). Info STERIS, [email to Sébastien Simard], [online], [email protected]
Active ingredient(s) Concentration Chlorophene 8.5% O-phenylphenol 10% P-tert-pentylphenol 2% Dilution rate recommended by the manufacturer: 0.4% Contact time recommended by the manufacturer: 10 minutes Protocol when combined with propylene glycol: N/A
Useful information on disinfectants after contamination with SECD | November 2014 9
Name of product: Bioxy Enviro DIN: 02431734 Manufacturer: Bioxy AFD inc.
3485 Ashby Ville Saint-Laurent QC H4R 2K3
Website: www.bioxyafd.com (site under construction) Contact person (tech.): Fadi Dagher, Ph.D. Tel.: 514 745-2597 Cell: Fax: 514 745-5176 Email: [email protected] Distributor: Atomes Bio
3485 Ashby Ville Saint-Laurent QC H4R 2K3
Website: www.atomesbio.com Contact person: Alain Brunet Tel.: 514 830-9447 Cell: Fax: Email: [email protected] Class: Disinfectant Type of product: White powder Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes: Reference: GOYAL, Sagar (2014), Report – Virucidal efficacy of Bioxy H Powder
against PEDV (porcine epidemic diarrhea virus), Minneapolis, University of Minnesota.
Active ingredient(s) Concentration Sodium Carbonate Peroxyhydrate 30-70% Alkyl (68% C12, 32% C14) dimethyl ethylbenzyl ammonium chloride
2%
Alkyl dimethyl benzyl ammonium chloride (C12-18)
2%
Useful information on disinfectants after contamination with SECD | November 2014 10
Name of product: Bioxy Enviro Dilution rate recommended by the manufacturer: 1% (10g/L) Contact time recommended by the manufacturer: 15 minutes Protocol when combined with propylene glycol:
20% of propylene glycol recommended
Useful information on disinfectants after contamination with SECD | November 2014 11
Name of product: Boost 1000 & Boost 1001 DIN: Manufacturer: Website: Distributor: Ecolab Canada
2222 Dagenais Ouest, Suite #201 Laval QC H7L 5Y2
Website: www.ecolab.ca Contact person: Éric Chatigny Tel.: 514 781-2622 Cell: Fax: Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes: Boost 1000 and Boost 1001 are equivalent to Sterilex Ultra Kleen
Solution, available in Canada. Sterilex Ultra Kleen Solution is the liquid version of Sterilex Ultra Powder. Once combined, solutions 1 & 2 create the same chemical reaction as Sterilex Ultra Powder. Sterilex Ultra Powder and Sterilex Ultra Kleen Solution are not available in Canada.
Reference: GOYAL, Sagar (2014), Report – Virucidal efficacy of Sterilex Ultra
Powder against PEDV (porcine epidemic diarrhea virus), Minneapolis, University of Minnesota.
Useful information on disinfectants after contamination with SECD | November 2014 12
Name of product: Boost 1000 & Boost 1001 Active ingredient(s) Concentration
Boost 1000
n-Alkyl (C14 60%, C16 30%, C12 5%, C18 5%) dimethyl benzyl ammonium chloride
n-Alkyl (C12 68%, C14 32%) dimethyl ethylbenzyl ammonium chloride
Hydrogen peroxide
Boost 1001
Potassium carbonate
Sodium carbonate
Tetrasodium EDTA
Dilution rate recommended by the manufacturer: 10% Contact time recommended by the manufacturer: 20 minutes Protocol when combined with propylene glycol: N/A
Useful information on disinfectants after contamination with SECD | November 2014 13
Name of product: Clorox Clean-Up Disinfectant Bleach Cleaner DIN: 02319470 Manufacturer: The Clorox Company of Canada Ltd.
150 Biscayne Crescent Brampton ON L6W 4V3
Website: http://clorox.ca/fr/ Distributor: Groupe Xtrême
3165 De Miniac Saint-Laurent QC H4S 1S9
Website: www.groupxtreme.com Contact person: Martin Lavigne Tel.: Cell: 613 859-9334 Fax: Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes:
References: HOFMANN M, and R. WYLER (1989). ”Quantitation, biological and physicochemical properties of cell culture-adapted porcine epidemic diarrhea coronavirus (PEDV)”, Vet Microbiol, Jun; 20(2), p. 131-142.
POSPISCHIL A, STUEDLI A, KIUPEL M, et al (2002). ”Update on porcine epidemic diarrhea”, J Swine Health Prod. Vol. 10(2), p. 81-85.
Active ingredient(s) Concentration Sodium hypochlorite 1.84% Dilution rate recommended by the manufacturer: 3% Contact time recommended by the manufacturer: 10 minutes Protocol when combined with propylene glycol: Do not combine.
Useful information on disinfectants after contamination with SECD | November 2014 14
Name of product: Gluquat 2 DIN: 02318393 Manufacturer: West Penetone Inc.
10 900 Secan Street Anjou QC H1J 1S5
Website: www.westpenetone.com Distributor: West Penetone
10 900, rue Sécant Montréal QC H1J 1S5
Website: www.westpenetone.com Contact person: Alexandre Marenger Tel.: 514 355-4660 Ext. 3025 Cell: 514 248-6061 Fax: 514 355-2319 Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes:
Reference: MARENGEER-DAVIES, Alexandre (June3, 2014), RE: WEST PENETONE
products, [email to Sébastien Simard], [online], [email protected]
Active ingredient(s) Concentration Benzalkonium chloride 8.0% Didecyl dimethyl ammonium chloride 3.0% Dioctyl dimethyl ammonium chloride 3.0% Octyl decyl dimethyl ammonium chloride 6.0% Glutaral 7.5% Dilution rate recommended by the manufacturer: 0.4% Contact time recommended by the manufacturer: 10 minutes Protocol when combined with propylene glycol: N/A
Useful information on disinfectants after contamination with SECD | November 2014 15
Name of product: Multi-Phenolique Disinfectant DIN: 00872962 Manufacturer: Bio Agri Mix LP
11 Ellens Street Mitchell ON N0K 1N0
Website: www.bioagrimix.com Distributor: Bio Agri Mix LP
11 Ellens Street Mitchell ON N0K 1N0
Website: www.bioagrimix.com Contact person: Jean-Noël Côté Tel.: 418 386-1745 Cell: 418 570-9373 Fax: 418 386-1746 Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes: Same active ingredients as 1 Stroke Environ.
References: HOFMANN M, and R. WYLER (1989). ”Quantitation, biological and
physicochemical properties of cell culture-adapted porcine epidemic diarrhea coronavirus (PEDV)”, Vet Microbiol, Jun; 20(2), p. 131-142.
POSPISCHIL A, STUEDLI A, KIUPEL M, et al (2002). ”Update on porcine epidemic diarrhea”, J Swine Health Prod. Vol. 10(2), p. 81-85.
Active ingredient(s) Concentration Chlorophene 8.5% O-phenylphenol 10% P-tert-pentylphenol 2% Dilution rates recommended by the manufacturer: 1-2% Contact time recommended by the manufacturer: N/A Protocol when combined with propylene glycol: N/A
Useful information on disinfectants after contamination with SECD | November 2014 16
Name of product: PF 300 DIN: 02248634 Manufacturer: Dubois Chemicals Canada Inc.
1155 North Service Road West, Unit 6 Oakville ON L6M 3E3
Website: www.duboischemicals.com Distributor: Bio Agri Mix LP
11 Ellens Street Mitchell ON N0K 1N0
Website: www.bioagrimix.com Contact person: Jean-Noël Côté Tel.: 418 386-1745 Cell: 418 570-9373 Fax: 418 386-1746 Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes: No documentation confirming its effectiveness, but the active
ingredients and their concentrations are similar to GluQuat 2 and Synergize.
Reference: N/A
Active ingredient(s) Concentration Didecyl dimethyl ammonium chloride 6.72% Glutaral 12.5% Dilution rates recommended by the manufacturer: 1% (truck) and 2% (unloading dock) Contact time recommended by the manufacturer: N/A Protocol when combined with propylene glycol: Max. of 60% of propylene glycol
Useful information on disinfectants after contamination with SECD | November 2014 17
Name of product: Prevention Concentration DIN: 02361396 Manufacturer: Virox Technologies Inc.
2770 Coventry Road Oakville ON L6H 6R1
Website: http://www.virox.com/ Distributor: Farm Guard Products
36881 Dungannon Road Dungannon ON N0M 1R0
Website: www.farmguardproducts.com Contact person: Tel.: 519-529-3586 Cell: 519-955-7725 Fax: Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☐ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☒
Additional notes: Effectiveness estimated in function of that against human
coronavirus only, without studies to confirm this.
Reference: GIVEHCHI, Babak (2014), Re: PREVention Concentrate effective against
Porcine Epidemic Diarrhea virus (PEDv), Oakville, Virox Technologies inc. Unpublished paper.
Active ingredient(s) Concentration Hydrogen peroxide 7% / p/p Dilution rates recommended by the manufacturer: Disinfection – 2.5%
Sanitizing – 0.8% Light duty cleaning– 0.4%
Contact time recommended by the manufacturer: Disinfection – 5 minutes
Sanitizing – 30 seconds Light duty cleaning– 30 seconds
Protocol when combined with propylene glycol: N/A
Useful information on disinfectants after contamination with SECD | November 2014 18
Name of product: Synergize DIN: 02260336 Manufacturer: PRESERVE INTERNATIONAL
Po Box 17003 Reno NEVADA UNITED STATES 89511
Website: http://www.preserveinternational.com/ Distributor: S.E.C. Repro
86, rue Roy Ange Gardien, De Rouville QC J0E 1E0
Website: www.secrepro.com Contact person: Louis Bonneville Tel.: 1 888 446-4647 Cell: Fax: 450 293-0157 Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes:
Reference: AASV (Page consulted on May 21, 2014), Evaluation of a Protocol for
Sanitizing PEDV – Positive Transport Vehicles, [online], http://www.aasv.org/news/story.php?id=7225
Active ingredient(s) Concentration Benzalkonium chloride 26.0% Glutaral 7.0% Dilution rate recommended by the manufacturer: 0.8% Contact time recommended by the manufacturer: 5-12 minutes Protocol when combined with propylene glycol: Maximum of 10% of propylene glycol
Useful information on disinfectants after contamination with SECD | November 2014 19
Name of product: Tek-Trol DIN: 02239409 Manufacturer: BIO-TEK DIVISION OF A.B.C. COMPOUNDING CO. INC.
6970 Jonesboro Road Morrow GA UNITED STATES 30260
Website: http://abccompounding.com/ Distributor: S.E.C. Repro
86, rue Roy Ange Gardien, De Rouville QC J0E 1E0
Website: www.secrepro.com Contact person: Louis Bonneville Tel.: 1 888 446-4647 Cell: Fax: 450 293-0157 Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes:
References: HOFMANN M, and R. WYLER (1989). ”Quantitation, biological and
physicochemical properties of cell culture-adapted porcine epidemic diarrhea coronavirus (PEDV)”, Vet Microbiol, Jun; 20(2), p. 131-142.
POSPISCHIL A, STUEDLI A, KIUPEL M, et al (2002). ”Update on porcine epidemic diarrhea”, J Swine Health Prod. Vol. 10(2), p. 81-85.
Active ingredient(s) Concentration Chlorophene 10.8% O-phenylphenol 12,1% P-tert-pentylphenol 4,1% Dilution rate recommended by the manufacturer: 0.4% Contact time recommended by the manufacturer: 10 minutes Protocol when combined with propylene glycol: N/A
Useful information on disinfectants after contamination with SECD | November 2014 20
Name of product: Thymox DIN: 02333783 Manufacturer: LABORATOIRE M2 INC
4005-A Rue De La Garlock Sherbrooke QC J1L 1W9
Website: http://www.thymox.com/en/ Distributor: Syrvet Canada
207A, des Alouettes St-Alphonse-de-Granby QC J0E 2A0
Website: www.syrvetcanada.ca Contact person: Réal Sauvage Tel.: 1 888 779-7838 Cell: Fax: 450 361-1505 Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☐ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☒
Additional notes: No specific test against Porcine Coronavirus but proven efficacy
against humane coronavirus.
References: ATS labs, FINAL STUDY REPORT, Virucidal efficacy of a Disinfectant for Use on Inanimate Environmental Surfaces Virus: Porcine Epidemic Diarrhea Virus, August 29 2014 [Document non publié]
ATS labs, FINAL STUDY REPORT, ATS labs, FINAL STUDY REPORT, Virucidal efficacy of a Disinfectant for Use on Inanimate Environmental Surfaces Virus: Human Coronavirus, March 4 2011 [Document non publié]
REORBIT (Page consultée le 11 juin 2014), THYMOX fights back against Porcine Epidemic Diarrhea, [en ligne], http://www.redorbit.com/news/health/1113088308/thymox-fights-back-against-porcine-epidemic-diarrhea/
Useful information on disinfectants after contamination with SECD | November 2014 21
Name of product: Thymox
Active ingredient(s) Concentration Thymol 23% / p/v Dilution rate recommended by the manufacturer: 1% Contact time recommended by the manufacturer: 1 minute (for transport trailers
disinfected inside in winter, follow the 10-minute contact time before going outside and being exposed to frost).
Protocol when combined with propylene glycol: 30% propylene glycol recommended
Useful information on disinfectants after contamination with SECD | November 2014 22
Name of product: Virkon DIN: 02125021 Manufacturer: VETOQUINOL N A INC
2000 Chemin Georges Lavaltrie QC J5T 3S5
Website: www.vetoquinol.ca Distributor: VETOQUINOL N A INC
2000 Chemin Georges Lavaltrie QC J5T 3S5
Website: www.vetoquinol.ca Contact person: Marc Lalonde Tel.: 1 800 363-1700 Cell: 514 714-8398 Fax: 1 888 714-8386 Email: [email protected] Class:: Disinfectant Type of product: Powder Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☒ Swine coronavirus ☐ Human coronavirus ☐
Additional notes: References: ATS LABS (2014). Virucidal Efficacy of a Disinfectant for Use on Inanimate
Environmental Surfaces Virus: Porcine Epidemic Diarrhea Virus, Wilmington, DuPont Experimental Station, unpublished document.
NEOGEN Corporation (2014). Porcine Epidemic Diarrhea Virus (PEDV), [online], Lexington, www.neogen.com, (Page consulted on June 20, 2014)
The Pig Site (Page consulted on June 3, 2014). DuPont Virkon S Effective for Porcine Epidemic Diarrhea Virus (PEDV), [online], http://www.thepigsite.com/swinenews/36758/dupont-virkon-s-effective-for-porcine-epidemic-diarrhoea-virus-pedv
Active ingredient(s) Concentration Potassium peroxymonosulfate 21.4% / p/p Dilution rates recommended by the manufacturer: Disinfection 1%
Spraying 1% (0.25L/m2) Fogging 1%-5% (1-4L/100m3)
Contact time recommended by the manufacturer: 10 minutes Protocol when combined with propylene glycol: Maximum of 20% of propylene glycol
Useful information on disinfectants after contamination with SECD | November 2014 23
Name of product: Virocid DIN: 02239726 Manufacturer: CID LINES
Waterpoortstraat 2 Ieper BELGIQUE 8900
Website: http://www.cidlines.com/fr-be Distributor: Merial Canada Inc.
20000, Clark Graham Baie d’Urfé QC H9X 4B6
Website: www.merial.ca Contact person: Dominique Brault Tel.: 514 457-1555 Cell: 819 817-8383 Fax: 819 394-3002 Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes:
References: TER BEEK, Vincentter. (2014). Virocid successfully tested against PED
virus, The Pig Progress http://www.pigprogress.net/Health-Diseases/Outbreaks/2014/6/Virocid-successfully-tested-against-PED-virus-1534161W/ (Page consulted on June 19, 2014)
Cid Lines (2014). Virocid® Tested Against PEDv at 1:400 (1/3 oz/gal) at an EPA Accredited Lab, [online], Cid Lines http://www.virocid.be/virocid-tested-pedv-1400-13-oz-gal-epa-accredited-lab/ (Page consulted on June 19, 2014)
Active ingredient(s) Concentration Benzalkonium chloride 17.06% Didecyl dimethyl ammonium chloride 7.8% Glutaral 10.725%
Useful information on disinfectants after contamination with SECD | November 2014 24
Name of product: Virocid
Dilution rates recommended by the manufacturer: Cleaning, disinfection and sanitizing 0.25-0.5% (1L/10m2) Disinfection of transport equipment 0.5-1.0% Vehicle wheel wash 1.0% Foot wash, min. 1.0%
Contact time recommended by the manufacturer: 10 minutes Protocol when combined with propylene glycol: See protocol (max. 60% of PG at
51°C)
Useful information on disinfectants after contamination with SECD | November 2014 25
Name of product: VirStop DIN: Manufacturer: Website: Distributor: Constant America
7585, rue Cordner LaSalle QC H8N 2R5
Website: www.constantamerica.com Contact person: Denis Fortin Tel.: 514 761-3339 Ext. 345 Cell: 514 609-6413 Fax: Email: [email protected] Class:: Disinfectant Type of product: Liquid Known to be effective against:
PEDV ☒ Deltacoronavirus ☐ TGE ☐ Swine coronavirus ☐ Human coronavirus ☐
Additional notes: The composition of VirStop is more or less the same as PF 300,
Synergize and GluQuat 2, three products that have shown some level of effectiveness against PEDV.
Reference:
Active ingredient(s) Concentration Alkyl(benzyl)dimethylammonium chloride 3-7% Octyldecyldimethylammonium chloride 3-7% Dimethyldioctylammonium chloride 1-5% Didecyl dimethyl ammonium chloride 1-5% Glutaraldehyde 5-10% Ethanol 1-5% Dilution rates recommended by the manufacturer: 0.5-1.0% Contact time recommended by the manufacturer: 10 minutes Protocol when combined with propylene glycol: N/A