US TOO US TOO INTERNATIONAL, INCINTERNATIONAL, INC

US TOO GREATER QUAD US TOO GREATER QUAD CITIES PROSTATE CANCER CITIES PROSTATE CANCER

SUPPORT GROUPSUPPORT GROUP

The AnatomyThe Anatomy

STATISTICS:PROSTATE CANCERSTATISTICS:PROSTATE CANCER• The prostate is the #1 Cancer site in men

• 220K men are diagnosed each year

• The number of new prostate cancer cases will rise sharply as the “Baby Boomers” come of age

• 29K men die of prostate cancer each year (down from 40K men that used to die each year before DRE and PSA screenings were used

• AFRICAN-AMERICAN men have prostate cancer death rates over twice those of Caucasians (53.7/100K men VS. 24.1/10K)

• 1 in 6 men will develop Prostate Cancer

• Each person w/ Prostate CA is someone’s father, uncle, brother, son, etc.

• With early detection, prostate cancer has an 85-95% cure rate

• In early stages, treatments are far less traumatic

Relationship of the PSA Level to thePrevalence of Prostate Cancer and High-Grade Disease

PSA Level # of men Men with Men with hi-grade (N=2950) Prost. CA Prost. CA

(N=449) (N+67)

0 - 0.5 ng/ml 496 32(6.6) 4/32 (12.5)0.6-1.0 ng/ml 791 80 (10.1) 8/80 (10.0)1/1-2/0 ng/ml 998 170 (17.0) 20/170 (11.8)2.1-3.0 ng/ml 482 115 (23.9) 22/115 (19.1)3.1-4.0 ng/ml 193 52 (26.9) 13/52 (25.0)

*High-grade disease = Gleason score > 7. PSA < 4.0 ng/ml. Reproduced with permission from: Thompson, M, Pauler, DK, Goodman, PJ, et al. N

Engl J Med 2004; 350:2239. Copyright C 2004 Massachusetts Medical. Prevalence of prostate cancer among men with a prostate-specific antigen level >4.0 ng

Prostate cancer is NOTProstate cancer is NOT just an old man’s disease! just an old man’s disease!

• Literature on prostate cancer usually states that older men in their 60s or 70s are more likely to get the disease.

• More men in their late 40s and early 50s are being diagnosed with prostate cancer.

SYMPTOMS: PROSTATE CANCERSYMPTOMS: PROSTATE CANCER

• NO SYMPTOMS (EARLY STAGE CA)• Blood in urine• Pain or difficulty urinating• Increased frequency of urination, often at night• Increased urgency to urinate• Inability to urinate• Pain/discomfort in area of prostate (near rectum)• Unexplained weight loss• Unusual, persistent bone pain (usually spine)

PROSTATE CANCER:PROSTATE CANCER:THE GENETIC LINKTHE GENETIC LINK

• NO FAMILY HISTORY OF CANCER (CA)

• FAMILY HISTORY OF CA OTHER THEN PROSTATE

• BOTH PARENTS W/ CA OTHER THEN PROSTATE

• DAD w/ PROSTATE CA, MOM w/ OTHER CANCER

• FATHER AND UNCLES(S) WITH PROSTATE CA

• GRAMPA, DAD & UNCLE(S) HAD PROSTATE CA

• 1 in 9 (11.2%)

• 2 in 9 (18.9%)

• 2 in 5 (42.6%)

• 1 in 2 (53.1%)

• 3 in 5 (61,7%)

• 4 in 5 (86.3%)

PROSTATE CANCERPROSTATE CANCERSCREENING SCREENING

RECOMMENDATIONSRECOMMENDATIONS

WHO SHOULD BE SCREENED?WHO SHOULD BE SCREENED?

Men over 40 w/ risks: Annual DRE &PSA (African American or w/ family history)

All men by age 45: Annual DRE & PSA

THE “MAN-O-GRAM”THE “MAN-O-GRAM”

The DREThe DRE

THE BENEFITS OF SCREENINGTHE BENEFITS OF SCREENING

Peace of mind!

Catching prostate CA early

Improving your odds of surviving

Detecting CHANGES in PSA

PSA: WHAT YOU SHOULD KNOW PSA: WHAT YOU SHOULD KNOW

• PSA stands for Prostate Specific Antigen

• All men should get a baseline PSA by age 45, then annually thereafter

• All men should know their PSA number

• Men should keep track of changes in their PSA # over time

• Don’t accept this answer from your Dr: “Your PSA is normal”

WHAT IS A “GOOD” PSA READING?WHAT IS A “GOOD” PSA READING?

• One that stays CONSTANT!

• An increase of 25% in one year means you should get checked again in 6 months

• If PSA continues to rise sharply, get biopsy

PROSTATE CANCER PROSTATE CANCER TREATMENT OPTIONSTREATMENT OPTIONS

• RADICAL PROSTATECTOMY– Perineal

– Retropubic*

– Laproscopic*

*Nerve Sparing Procedures

PROSTATE CANCER PROSTATE CANCER TREATMENT OPTIONSTREATMENT OPTIONS

RADIATION THERAPY

• External Radiation

– IMRT: Intensity-Modulated Radiation Therapy– Conformal Radiation– 3-D Radiation– Proton Beam Radiation

PROSTATE CANCER PROSTATE CANCER TREATMENT OPTIONSTREATMENT OPTIONS

• BRACKYTHERAPY (Internal Radiation)

– Paladium Seeds

– Iodine Seeds

– High Dose Therapy

PROSTATE CANCER PROSTATE CANCER TREATMENT OPTIONSTREATMENT OPTIONS

• Hormone Therapy

• Cryotherapy

• Thermal Therapy

• Watchful Waiting

WHAT YOU NEED TO KNOW WHAT YOU NEED TO KNOW ABOUT PROSTATE CANCERABOUT PROSTATE CANCER

• If you have a family history, include DRE and PSA in your annual checkups

• Get to know your PSA numbers (make sure your PSA numbers are stable)

IF YOU IF YOU HAVEHAVE PROSTATE CA PROSTATE CA

• Know your PSA numbers

• Know your Gleason Score

• Find a support network or group to get unbiased info on treatment options