2011-3-1

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Portable medical and health care products-- A new driver for IC development

Zhihua WANG

Professor of Tsinghua University

Zhihua@tsinghua.edu.cn

报告内容

• Overall information in 2010 of IC design industries in Mainland China

• A short introduction of Institute of Microelectronics in Tsinghua University

• The requirement of the research for the IC design in the Medical and Health care applications

• Examples of on going projects

2011-3-1

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Overall information in 2010 of IC design industries in Mainland China

The Overview Integrated Circuits design industry in 2010 in Mainland China

• 据不完全统计，2010年全行业销售额有望达到550亿元人民币，比2009年增长45%。– 占全球设计业的份额提升到11.85% – 10年间全行业年均复合增长率达到45%

• According to incomplete statistics total sales of Integrated Circuits industry of Mainland China in 2010 expected to reach 55 RMB billion , up 45% Increasing over 2009.– Share of global market of IC design industry raised to

11.85%– CAGR (compound annual growth rate) in last 10 Years is

about 45%

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Top 10 IC design companies of ManilandChina in 2010

• There are three companies do not want to list their names

2009年销售额

Sales in 2009

2010年上半年销售额

Sales in Jan.- Jun.

估计2010年销售额Sales for 2011

(Estimated)

同比增长

an increaseof 2009

1 深圳海思半导体有限公司 (Hisilicon) 39.1076 17.2327 45.7279 17.00%2 展讯通信(上海）有限公司 (Spreadtrum) 7.52 9.5 20 165.96%3 中电集团五十五所 (NEDI of CETC) 12 8 15 25.00%4 中国华大集成电路设计集团公司 (CIDC) 14.04 14.41 2.63%5 大连连顺集团公司 (Lianshun Electronics) 11.22 6 14 24.70%6 ﹡﹡﹡﹡﹡﹡﹡﹡﹡﹡﹡﹡ 8.03 5.17 13.6 69.00%7 ﹡﹡﹡﹡﹡﹡﹡﹡﹡﹡﹡ 8.12 13.2 62.56%8 深圳市国微控股股份有限公司 (StateMicro) 5.2494 5.9045 11.289 115.00%9 ﹡﹡﹡﹡﹡﹡﹡﹡﹡﹡﹡﹡﹡﹡ 9.3 5 11 18.28%

10 国民技术股份有限公司★ (Nationz Technologies) 4.6585 3.84 10 114.66%

(100 million RMB ￥)

名次

(Rank)企业名称

Company

Source: China Semiconductor Industry Association IC Design Branch

Top 10 IC design companies of ManilandChina in 2010

Source: An independent analysts名次

(Rank)企业名称

Company营销额

Sales (million $)

1 展讯通信（上海）有限公司(Spreadtrum) 3452 锐迪科微电子（上海）有限公司(RDA Microelectronics) 213 比亚迪股份有限公司 (BYD Company) 154 上海泰景信息科技有限公司 (Telegent Systems) 145 格科微电子(上海)有限公司 (GalaxyCore Inc) 135 联芯科技有限公司 (LeadCore Technologies) 137 国民技术股份有限公司 (Nationz Technologies) 118 深圳市海思半导体技术有限公司 (Hisilicon) 108 深圳国微技术有限公司(StateMicro Electronics) 10

8 中星微电子有限公司 (ViMicro) 10

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Geographical distribution of IC design companies in Mainland

China

2009年销售额Sales in 2009

2010年上半年销售额

Sales in Jan.- Jun.

估计2010年销售额Sales for 2011

(Estimated)

同比增长

an increaseof 2009

北京（Beijing） 90 115 27.00%

大连（Dalian） 12.5 6.5 15 20.00%

天津（Tianjin） 1.2 0.808 1.7 41.60%

上海（Shnaghai） 56 46.6 97 78.57%

无锡（Wuxi） 37 24.3 50 35.14%

苏州（Suzhou） 9 6.8 13 44.44%

南京（Nanjing） 6 12 24.3 400.00%

杭州（Hangzhou） 25.5 32 25.49%

深圳（Shenzhen） 70.5 43.4 91.9 30.35%

珠海（Zhuhai） 5 3 6 20.00%

香港（Hong Kong） 6 7 16.67%

福州（Fuzhou） 6.5 4 9.8 50.77%

厦门（Xiamen） 1.5 1.447 7 466.60%

成都（Chengdu） 11.5 7.3 15.8 37.39%

西安（Xi'an） 5 4 9 80.00%

重庆、绵阳

（Chongqing, Mianyang）1.5 1.87 4.67 311.30%

345.3 499.17 44.56%

379.8 549.087 44.57%

人民币亿元 (RMB 100 million)

地区(城市)Region (city)

其它有统计地区

Other statistical areas

合计（＝小计×1.1）Total (=Sub-total ×1.1)

以上统计额小计（ Sub-total）

京津环渤海

Beijing- Tianjin andBohai Sea area

长江三角洲

Yangtze River Delta

珠江三角洲

Pearl River Delta

23.99%

39.39%

22.16%

5.37% 9.09%

京津环渤海

Beijing- Tianjin and Bohai Sea area长江三角洲

Yangtze River Delta

珠江三角洲

Pearl River Delta

其它有统计地区

Other statistical areas

其他地区

Others

A great deal of wealth in China were consumed by integrated circuits (2004~2009)

• The situations of IC market of China in the world(unit: 100 million U.S. dollars)

• The global market size and value of imports of China's IC

• China's IC imports, domestic values and comparison of the value with crude oil

• Global semiconductor market• The value of IC imports of China

• Crude oil imports of China• IC imports of China• China’ IC domestic values

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A short introduction of Institute of Microelectronics in Tsinghua University

• Founded in 1911, the last year of Qing Dynasty, as Tsinghua Preparatory School (清华学堂） for sending Chinese students to study abroad by the “Boxer Indemnity (庚子赔款)”

• Royal “Tsinghua Garden” as the university headquarter

2011-3-1 Zhisheng Niu @ Tsinghua University 10

Centennial TSINGHUA

2011-3-1

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2011-3-1 11

National Tsinghua University since 1928

• 3 Schools in 1928– Humanities– Sciences– Law

• School of Engineering since 1932– Civil– Mechanical – Electrical

Original (2nd) GateOriginal EE BuildingZhisheng Niu @ Tsinghua University

Auditorium (Big Hall)

15 Schools with 50 Departments, (55 departments in total)

Department of Electronic EngineeringDepartment of Computer Science and TechnologyDepartment of AutomationSchool of Software

Institute of MicroelectronicsDepartment of Microelectronics and Nanoelectronics

SciencesArchitectureMechanical EngineeringInformation Science & TechnologyCivil EngineeringEconomics and Management (’84)Humanities and Social Science (’93)Law (’99)Arts and Design (‘99)Public Policy & Administration (‘00)Journalism and Communication(’02)Aerospace (’04)Medicine (‘06, Peking Union Medical College)Marxism (‘08)

4 divisions

IC and System design research Solid state devices and integration technologies

Micro/nano devices and systemCAD technologiesEnvironmental Science and Engineering

Electrical EngineeringEngineering Physics Chemical EngineeringMaterials Science and Engineering

5 Independent Departments In additional

Institute of Nuclear and New Energy Technology

1 Research Institute

Art Center of Tsinghua UniversityGraduate School at ShenzhenSchool of Continuing Education

Other Educational orgnization

Campus (hectares) 405.5Research Fund (2009): 360M USD

Institute of Microelectronics of Tsinghua University

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清华大学微电子所的基本数据

Basic Facts of Institute of Microelectronics of Tsinghua University

• 在职事业编制人员/Total Faculty and Staff ： 96– 正高/Professors ：14– 副高/ Associate Professors ：29– 中级/ Teaching Faculty ：16

• 学生总数/Total Number of Students ：586– 本科生/Undergraduate Students ：107– 全日制硕士/ Full time Masters Students ：385

• 工学硕士/Full time students of Master of science in Engineering ：82

• 全日制工程硕士/ Full time students of Master of Engineering ：278

– 在职工程硕士/ Part time students of Master of Engineering ：：25

– 博士研究生/ Ph. D. Candidates ：94

（by Sept 2010）

Research Funding in last 10 years in Institute of Microelectronics on Tsinghua University

• Research funds accumulated from 2001 to 2010 of IME : 314.32 (million RMB)

• Research funds of TsinghuaUniveristy in 2010 is about 3.6billion RMB (roughly half of the country's total in all Universities)

9.8

10.6

13.9

21.1

24.3

16.7

23.0

18.2

44.3

132.

3

0.0

20.0

40.0

60.0

80.0

100.0

120.0

140.0

Research funding in 2001~2010 (million RMB)

4077.64 30.78%

818.44 6.18%

4854.12 36.64%

3497.99 26.40%

funds in the laboratories in 2010(Ten Thousands RMB)

IC DesignCAD13945.22

45.15%

2921.68 9.46%

7618.24 24.67%

6401.50 20.73%

Accumulated funds in the laboratoriesin 2001～2010 (Ten Thousands RMB)

IC Design

CAD

Process

Devices

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90

Do things best in the world, and, let the world know we are

the best

To be useful is always the main driven force of the progress of IC technologies

9090904545

应用需求推动的技术研究

Application Oriented research

先进技术的新应用

Application of new technologies

低功耗数字（陈虹、麦宋平*）Low power digital(Hong Chen, Songping MAI)

高性能数字（谢翔、麦宋平*）High performance digital(Xiang XIE, Songping MAI)

高精度数模混合（李冬梅**－刘力源**）High Precision, lower power mix-model integrated

circuits(Dongmei LI, Liyuan LIU)

高速度数模混合（李福乐）

High speed mix-model IC (Fule LI)

模拟和功率集成

（王自强、姜汉钧、贾晨）

Analog and power integrated circuit(Ziqiang WANG, Hanjun JIANG and Chen JIA)

射频与收发器（张春、池保勇）

RF integrated circuit and Transceiver(Chun ZHANG, Baoyong CHI

微波与射频集成电路（李宇根、池保勇）

Millimetre -Wave and RF (Woogeun Rhee, Baoyong CHI)

Application of Electronics in Artificial knee Knee Replacement(Hong CHEN)

Multi-sensor detection of digestive tractsignal processing of multi-sensor image For medical application

contactless power supply Technologies for Medical micro-system(Xiang XIE)

Low-power RF transceiver for digestive tract detection(Fule LI)

Low-power SoC and system for the digestive tract detection(Hanjun JIANG)

Wireless Remote Control Switch with a zero Standby power(Ziqiang WANG and Chen JIA)

A/D and D/A convertor (Dongmei LI, Fule LI and Liyuan LIU)

C-F Converter andPosition sensor(Ziqiang WANG)

Programmable nerve stimulator (Chun ZHANG, Songping MAI)

Reconfigurable RF Transceiver Design for mobile communication, Navigation and

medical application(Baoyong CHIA)

RFID chip design for tag and reader(Chun ZHANG)

Low power SoC chip design for Cryptography(ChunZHANG, Songping MAI)

Chip design for Millimetre -Wave, RF and single chip radar(Zhihua WANG, Baoyong CHI and Woogeun Rhee)

* 深圳研究生院Graduate School at Shenzhen

** 电子工程系Dept of EE

并行计算结构及技术（邓仰东、谢翔）

Millimetre -Wave and RF (Woogeun Rhee, Baoyong CHI)

三维图像获取与处理技术（谢翔）

3－D image Capture And processing (Xiang XIE)

Research aspects and team members in the Zhihua WANG’s group

10 with IME2 with EE1 with Graduate school at ShenZhen

The requirement of the research for the IC design in the Medical and

Health care applications

It is a hot topic in ISSCC2011

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The Major Puzzle for Academe Today

• John H. McMasters, Thoughts on the Engineer of 2020 -An Early 21st Century [Aerospace] Industry Perspective, January 14, 2006

Give me g

rads who ca

n do

my work

.

To support the industries to make innovation

支持建立以企业为核心的创新体系

选择科研方向的准则

The criteria to support a suitable research topic• 选题要对工业界有用

Demand by industry

• 存在科学/技术问题There exist science/technique unknown

• 要能积累（不能打一枪换一个地方，“家有常业，虽饥不饿；国有常法，虽危不亡”）

Must be able to accumulate “know how”

• 不做（工业界）主流，不离开主流

Never to do things in the main stream and to compete with industries, and, never to be distant from the main stream – 钱、人

research funding, and, talent

– 学生要找工作

The student must get Jobs after they graduated

• 做世界上最好的事情，同时，让世界上（同行）知道我们做的最好

To do things best in the world, and, let the world know we are the best

面向系统应用研究集成电路设计技术

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Important!!!DO USEFUL THINGS

What is the useful application??

History will give us inspiration

电脑变得无处不在

Computers become omni-present…

20

1946: using vacuum tubes In 64 years, From 200 bytes filling a big room and consuming 150 KW, to 32 Gbytes

filling your pocket and consuming 2W

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Computing: ultimately hiding in every-thing

21

15BDevices

普适

Pervasive

嵌入式

Embedded

互联网——每周七天，每天24小时，出现在人类生活的全部场景

Internet – 7x24, Every Modality of Life

科研人员Researchers

大型机

Mainframes服务器、

桌面机

Servers, PC’s

普通人

Many

移动电话

Cell Phones

无处不在

Ubiquitous

计算技术的进展：隐藏在任何物品内部

The evolution in computing: ultimately hiding in every-thing...

22

直到移动电话的出现，接口技术保持类似的形态

Till the cell phone, the interface remained the same

To be able to hide electronicsautonomous operation is needed;enabled by More than Mooreand implemented on top of CMOS: CMORE

AnalogFrontEnd

ADC

DSP

Radio

μC

Sensor

Power management, battery, harvester

14

15BDevice

s

普适Pervasive

嵌入式

Embedded

互联网——每周七天，每天24小时，出现在人类生活的全部场景

Internet – 7x24, Every Modality of Life

科研人员Researchers

大型机Mainframes

服务器、

桌面机Servers, PC’s

普通人Many

移动电话Cell Phones

无处不在Ubiquitous

为了把电子器件隐藏起来，需要自主运行，要求在CMOS技术之外的实现技术: CMORE

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从今天的医疗周期

FROM Current Health care cycle

23

变换到未来的分布式医疗保健周期

TOWARDS DISTRIBUTED CARE ROUTINE

分布式治疗流程

(Distributed Care Routine):

• Person/Patient Centric

• Minimum disturbance to daily life

• Efficient for patient

• Low or ‘reduced’ cost

集中治疗流程

(Centralized Care Routine):

• Data Centric (empirical)

• Disturbance for patient

• Efficient for curative care

• Expensive

医学检测和监护

Medical Tests &Monitoring

诊断Diagnostics

医学处理Treatment

感到不适

Sense of Discomfort

医学检测和监护

Medical Tests &Monitoring

诊断

Diagnostics

医学处理

Treatment

感到不适

Sense of Discomfort

技术引擎ENABLERS

24

医学检测和监护Medical Tests &

Monitoring

诊断Diagnostics

医学处理Treatment

感到不适Sense of

Discomfort

便携式的医疗监护系统(Portable medical monitoring systems):

Reliable and seamless monitoring systems that can be integrated into patients daily life routine

门诊数据分析(Ambulatory data analysis):

Real-time data analysis and even diagnostics increasing the efficiency of health-care delivery

闭环处理(Close the loop):

疾病预防保健所需要的智能药物释放/刺激系统(Smart drug delivery and/or stimulation systems for preventive care)

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Growth in the market for 25 years, may the main driving force of the semiconductor market

• Databeans (May 2010) – Medical electronics market is

estimated at $128.6 billion in 2010. 到2015年估计为$191.1 billion , In next 5 years (to 2015) average annual growth rate estimated at 8%

– Medical IC market is estimated at $3 billion in 2010 （ The total IC market is $226 billion）

• in clinical: $1.8 billion, • imaging: $355 million,• home medical applications: $728 million

– In next 5 years (to 2015) average annual growth rate estimated at 10%

Source: MDDI, Databeans, National Coalition on Health Care

CAGR: 1979-2007 = 10%

1970 1980 1990 2000 2010 2020

Microprocessor

DesktopComputer

Packaged IC

Military & Aerospace

SoC, VLSI, DSP

Communications

MultiprocessingGiga bit,

non-volatilememory

Converged Appliances

Consumer / ComputerCommunications

System of Systems

Auto, aerospace,medical,

Example target application: ECG patch

• Marketing specification– Patch to be worn continuously for at least 7 days– Comfortable: flexible, stretchable, thin– Fully disposable– Medical grade quality; monitor arrhythmia patient– Works well in daily life including sports

26

• 市场需求

– 足够坚固，可以连续工作至少7天

– 舒适：柔软、松紧合适，薄

– 一次性使用

– 医用级质量，长时间监测病人心律失常

– 在包括运动在内的日常生活中可正常工作

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心电监护的历史

History of ECG monitoring

27 Rudy Lauwereins

1903: how it all startedBedside (mains operated)

Handheld (2xAAA battery operated;2 hours autonomy)

Patch with match-box size clip-on (7 days autonomy)

预测不一定准

Prediction is not necessarily accurate

But … …

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1954年兰德公司预测的2004年家用计算机的形态

正在开展的研究

Examples of on going projects

举例

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Overview of the IC design for medical application

Biomedical integrated circuits

Wireless Endoscopy

Capsule System

Hearing Aid and Neural

stimulation

Wireless Monitoring for

the OrthopaedicImplants

WBSN

1st generation of Smart capsule

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1st Generation, Smart capsule, chip design and application

Capsule Endoscopy

2003 2008

Phase IResearch

Phase IIIProduction

2010

Supporting Equipment

Phase IIPre-Application

Sodar 2009.10

2003.04 Applied Patent: Digital Wireless Capsule

Endoscopy

2004.08 Applied National Key Technologies R&D Program

2005.04 Patent is Granted

2005 A-SSCC

Demo PCB System

2006.05 support students to Founded

Beijing E-Core Technology Co.

2006

2008 A-SSCC Student Design Award, EL 2008.7, TBCAS 2009.1 CJE 2009.6

Kelvin 2008.6

2006 JSSC

Production-Prototype

2008 Two National 863 Project with total 18 Million

System Design

IC Design

academic achievement based on 1st Generation Smart capsule

• 60+ Papers published on journal and conference, with – 10 papers cited by SCI

• 2 papers in JSSC

• 8 authorized patent, + 9 filed patent

• 5 graduated Ph. D. students

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Sensor controller

Signal processor

Image resolution: 307200 pixelsImage rate: 0~2fps

400MHz RF Transceiver

BA C

1st Generation, Smart capsule

A SoC with 400MHz RF transceiver with current multiplex technologies,self tuning of RF port, and, on chip clock calibration. The efficient of transmitter: 1.3nJ/bit (The best result In the world, less than 30% of published result)

A lower power reconfigurable transceiver

D

Multi frequency400~440MHz860~940MHz2.4~2.5GHz

Multi mode and date rate20, 50, 100, 200kbps, … , ASK

250, 500, 7500, 1000, 1500kbps, …, BPSK 125, 250, 500, 1000, 2000, 3000kbps, …, MSK25, 250, 500, 1000, 2000, 3000kbps, …, GFSK

MMTR200A

433MHzRF Transceiver

Wireless

Power Sw

itchLD

ORegu

altors

MCU &Image

Compressor SRAM 1(Image Buffer)

LEDDriver

DecouplingCapacitor

Array

SRAM 2(Image Buffer)

TestPort

ECS1020( SOC)

Technologies in Chip design

• Note that the marks on blocks (A, B, C and D)

• 2008.4: A SoC for Smart capsule was finished– The first SoC for Smart capsule with the two way communication mechanism– Low voltage design (MCU：0.18um CMOS, 0.9V)– On chip Dual clock and multi voltage power management

• 2008.11: Student design contest reward at A –SSCC– Only team from mainland China win this reward in A-SSCC up to now

• 2009.6: A Soc with 2.4GHz RF transceiver was finished– An asymmetrical RF transceiver architecture – A compromise technology of LNA and down-mixer in a receiver – Self -calibration of VCO center Frequency and the transmission character – Data rate of transmission : 5Mbps@ current less than 5mA

• 2010.1: A SoC with 400MHz RF transceiver was finished– Current multiplex technologies– Self tuning of RF port, and, on chip clock calibration– The efficient of transmitter: 1.3nJ/bit (The best result published)

RF Transceiver

Wireless

Power Sw

itchLD

ORegualtors

MCU &Image

Compressor SRAM 1(Image Buffer)

LEDDriver

DecouplingCapacitor

Array

SRAM 2(Image Buffer)

TestPort

Smart capsule SoC(2007.1~2010.12)

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Example of other applications for the Integrated circuits Originally designed for Smart capsule: mouth cavity Endoscope

Sensor controller

Part circuit in D

2.4GHz RF Transceiver

Circuit in A A lower power reconfigurable transceiver

Multi frequency400~440MHz860~940MHz2.4~2.5GHz

Multi mode and date rate20, 50, 100, 200kbps, … , ASK

250, 500, 7500, 1000, 1500kbps, …, BPSK 125, 250, 500, 1000, 2000, 3000kbps, …, MSK25, 250, 500, 1000, 2000, 3000kbps, …, GFSK

D (same chip as in the capsulesystem)

Fully disposable

Example of other applications for the Integrated circuits Originally designed for Smart capsule: Wireless video laryngoscopes

Part circuit in A or D

400MHz or 2.4GHz RF Transceiver

Sensor controller

Circuit in A

Fully disposable

A lower power reconfigurable transceiver

Multi frequency400~440MHz860~940MHz2.4~2.5GHz

Multi mode and date rate20, 50, 100, 200kbps, … , ASK

250, 500, 7500, 1000, 1500kbps, …, BPSK 125, 250, 500, 1000, 2000, 3000kbps, …, MSK25, 250, 500, 1000, 2000, 3000kbps, …, GFSK

D (same chip as in the capsulesystem)

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2+ed generation of Smart capsule

Multi-camera capsule (camera ball)

Multi-camera capsule (camera ball)

• Whole levels of lower power design – High energy efficient digital– Lower power RF/ Aanlog/mix-mode

• Energy transmission through wireless • The sensor for the movement and

direction of capsule• Image processing

– Compress and cording– Reorganization

直径15mm6个摄像头

Key technologies

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Technologies in Chip design

• only the parts need of chip design are shown

A lower power reconfigurable transceiver

Multi frequency400~440MHz, 860~940MHz

2.4~2.5GHz

Multi mode and date rate20, 50, 100, 200kbps, … , ASK

250, 500, 7500, 1000, 1500kbps, …, BPSK 125, 250, 500, 1000, 2000, 3000kbps, …, MSK25, 250, 500, 1000, 2000, 3000kbps, …, GFSK

D (same chip as in the capsulesystem)

Sensor controller #1

Circuit in A

Fully disposable

Sensor controller #2

Sensor controller #n

Center controller

Power generator from radio/ power management

Non-volatile memorycontroller

Part circuit in A or D

400MHz or 2.4GHz RF Transceiver

Circuit E

400MHz/2.4 GHz for signal

~10MHz for power

Power delivering Through the Biological tissue

A Maximal 50W Full-Bridge Inverter

The Center-drive Open-circuit Helix

AC Source

Omnidirectional Power Receiver with Multiple Coils

Transformer

To City Electricity

Human Body Model filled with

Physiological saline

36 cm

31 cm21 cm

Open-circuit

Open-circuit

7 mm

1.4*2.0mm2

0.18μm CMOS

Chip Die

A RedLED

Tuning Capacitors

Receiving Coils(upfront coil is removed)

3 mm

Open-Circuit

Open-Circuit

Self-synchronousRectifier X

Self-synchronousRectifier Y

Self-synchronousRectifier Z

Boost DC-DC X

LDO 2.6V

24MHz Clock

VCO

Boost DC-DC Y

Boost DC-DC Z

XChannel

YChannel

ZChannel

Bandgap

LDO 1.8V

LDO 1.2V

11KHz Clock

Other

UMC 0.18μm CMOSWirelessLily Chip 52 Pin 1.4mm * 2.0mm

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Prospective Results for application

• In the future, we will present a new Wireless Power Receiving Chip with novel circuits designed for several key applications.

One Wireless Power Receiving

Chip for Several Key

Applications

Wireless Powering Retinal Prosthesis

System

Wireless Powering Micro-Ball Endoscopy

Pacemaker with Wireless Powering

Rechargeable Battery

WPT

Wireless Power Recharge Pannel

Animal Experiment with Implanted

Wireless Powering Device

Other Biomedical Applications

神经刺激

Neural stimulation

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Phase I:Stimulator design

CI0001 (Zhang Chun)2000.04 Ph.D thesis

CI0307 (Dong Mian)2006.06 Ms. thesis

Granted Patent: an ASIC for Cochlear Implant

CIDSP0805 (Songping Mai)2008.12 Ph.D thesis

Granted Patents: Cochlear Prosthesis with implanted DSP

CI0810 (Zhijun Wang)2009.06 Ms. thesis

By Zhihua Wang, Chun Zhang,Tao Chen, Mian Dong

By Zhihua Wang, Chun Zhang,Songping Mai, Zhijun Wang

1996 2006 2009 2012

By Zhihua Wang, Chun Zhang, Songping Mai,Zhijun Wang, Yixin Zhao, et al.

Cochlear Implant（人工耳蜗）

Phase II:System design

Phase III:Product design

ICM’ 2005

VLSID’ 2006

ICSP’ 2004ICASSP’ 2006ICECS’ 2007APCCAS’ 2008

BioCAS’ 2009

DELTA’ 2008

An implantable, multi- channel, programmable, passive and/or active stimulator platform

• Type I Application (Specifications)– Number of channel: 2~4– Current amplitude: -10mA~10mA– Width of pulse ：2μs~15min– Iife time: 5~10 year– Programmable through the

contrrolor– 根据刺激电极位置不同，可衍生出其他类型的产品：

• 脑深部刺激器、胃肠刺激器、脊髓刺激器、膀胱刺激器

Various forms of application

• Type II Application (Specifications)– Number of channel

– Cocolear Implant：8~24– Retinal Implant： 16~1000

– Current amplitude：0~2mA– Width of pulse ：0~1ms– 体内电路工作能量由体外无线供给– 体外处理器实现复杂的语音或图像处理算法，可随时更新

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Type I application: Vagus nerve stimulator (VNS)I类典型应用：迷走神经刺激器

47

植入导线

刺激脉冲发生器（带电池）

刺激电极迷走神经

手握式遥控器

刺激控制软件

电感线圈耦合

治疗范围：癫痫、耐药性抑郁症、烦躁症等神经性疾病

（Epilepsy, Treatment-resistant depression, Anxiety disorder、……）

Type I Application

48

•Parkinson‘s disease（帕金森症）•Major depression（重性抑郁症）•Tourette syndrome（抽动秽语综合征）•Brain function recovery（脑功能修复）

•obesity management（肥胖控制）

脑深部刺激器Deep brain stimulator

胃肠刺激器Gastric stimulatorEnteric stimulator

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Type I Application

49

•Chronic pain relief（慢性疼痛缓解） •Bladder control for individuals with spinal cord injury（截瘫患者排尿控制）

脊髓刺激器Spinal cord stimulator

骶神经前根电刺激器

（膀胱功能刺激器）Sacral anterior root stimulator

Type II Application ：organ prosthesis

50

人工耳蜗Cocolear Implant

视觉假体

（人工视网膜）

Retinal Implant

治疗范围：耳聋、失明等有严重器官缺陷的疾病

Therapy: deafness, blindness and other serious organ defect diseases

眼内刺激器Intraocular stimulator

图像采集和处理器Image capture and processing circuitry

体内无线接收器Implanted wireless receiver

体外无线发射器External wireless transmitter

语音采集和处理器Speech sampling and processing circuitry

体外无线发射器External wireless transmitter

耳内刺激电极Implanted stimulating electrode

体内无线接收器Implanted wireless receiver

（Las Angeles Times, August 3, 2009 ）美国每千新生儿中有1~2个全聋患者，其中40％在三岁前植入人工耳蜗，这个比例比五年前增长了25％One or two of every 1,000 U.S. children are born profoundly deaf. About 40% of such children now receive a cochlear implant, up from about 25% five years ago.

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Cochlear ImplantNew architecture, IEEE ICASSP 2006

Speech processor

AGC

Computer InterfaceMicrophone

Demodulator (Rectifier)

DSP

Electrode array

Skin

Battery

Reference Voltage Source

A/D Modulator Comparator

Back telemetry

D/A Voltage-control current source

Switch array

Phase I:Prototype design

By Zhihua Wang, Chun Zhang, Songping Mai, Yixin Zhao, Guangqi Wang, Zhijun Wang, et al.

2009 2010 2012

Neural stimulator（神经刺激器）

Phase II:Product design

Implantable stimulator(Mini version for clinical trial)

Implantable stimulator(Complete version for production)

Programming wand

Wrist Magnet

PDA Controller

Deep brain stimulator

Gastric/Enteric stimulator

Spinal cord stimulator

Sacral anterior root stimulator

Vagus nerve stimulator

Working principle

Animal experiment

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Gastric Electrical Stimulator（胃电刺激器）

2010 Q2 2010 Q3 2010 Q4 2011 Q2

Deep-going corporation with China-Japan friendship hospital.与中日友好医院开展了深入的合作

2010.Q2(zoopery ver. 1)•Silicon rubber sealed•Ultra small size Φ17*6 mm•Ultra low power consumption•160mAh,

VNS1003(动物实验)前期

VNS1006(动物实验)最终版

VNS1009(正式产品)可送检

2010.Q3(zoopery ver. 2)•Silicon rubber sealed•small size 42*25*7 mm•low power consumption•400mAh,

2010 Q4(zoopery final)zoopery final ver.:•titanium sealed •small size 36*19*8 mm•low power consumption•450mAh,

Electrical Stimulation as Treatment for Obesity and Diabetes.电刺激治疗肥胖和糖尿病

Programming wand

Wrist Magnet

PDA Controller

Accessories:(系统配件)

2011.Q2(final product)Mass production ver.:•titanium sealed •silicon rubber connector•size 47*42*9 mm•low power consumption•2500mAh,

A big step in mechanical layout, material, process technique etc.机械设计，原材料

选购和加工工艺等方面取得突破

2011 Q4

用于人工关节手术的力平衡辅助测量装置

An force balance test device for artificial Orthopedic Implants

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552006 2009 20122008 2010 2011

Wireless Monitoring System of the Total Knee Arthroplasty

Ligament Balance Measurement Device

DC-DC

SubthresholdMicroprocessor Sar-ADC

Subthreshold SRAMSoC Integration

2007 ISCAS/EMBCPatent Granted

2008 ISCAS/CICC

2010 EMBCApplied Patent: Force BalanceSystem for TKA

2005 Applied Patent: Wireless Monitoring System of the

Orthopedic Implants

Phase II:System Design

Phase I:Pre-research

Phase III:Chip Design

Phase IV:SoC Design

Research on Power Harvesting from PZT

Phase I:System Design

Phase II:System Verification

Phase II:Pre-Production

2009 IEEE Trans. On BioCAS

2009 ICCCAS

2010 EMBC: Force balance measurement

system for TKA

• A chip used for a node of Wireless Body Area Sensor Networks

– Integrated RF+MCU+ADC, ------ SoCarchitecture;

– Multi-Rx modules for power-saving when idle, ------ Transceiver architecture;

– Wireless Programming, ------ MCU architecture;– DMA for accelerators, ------ MCU architecture;– Multi-purpose sensor , ------ Applicable

architecture;– Low power, ------ Test results;

Rx_s

el

ant_

sel

Trim

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DM

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rbite

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Arbi

ter

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57

•完成了各模块芯片的设计测试；•第一版张力测量系统已经完成并得到验证；•专利：6项国内专利，已授权2项。

已经取得的阶段性成果

DC-DC

SubthresholdMicroprocessor Sar-ADC

0 100 200 300 400 500 600 700 800 9000

0.2

0.4

0.6

0.8

1

1.2

1.4

Load Resistor(KOhms)

Ave

rage

Pow

er(m

W)

Thanks

By Zhihua WANG

zhihua@tsinghua.edu.cn