us 20120305174a1 (19) united states (12) patent...

US 20120305174A1

(12) Patent Application Publication (10) Pub. No.: US 2012/0305174 A1 (19) United States

Trout et al. (43) Pub. Date: Dec. 6, 2012

(54) LAYER PROCESSING FOR PHARMACEUTICALS

(75) Inventors: Bernhardt Levy Trout, Lexington, MA (US); Trevor Alan Hatton, Sudbury, MA (US); Emily Chang, Edison, NJ (US); James MB Evans, Sudbury, MA (US); Salvatore Mascia, Boston, MA (US); Won Kim, Gyeonggi-Do (KR); Ryan Richard Slaughter, Riverside, CA (US); Yi Du, Union Township, NJ (US); Himanshu Hemant Dhamankar, Cambridge, MA (US); Keith M. Forward, Somerville, MA (US); Gregory C. Rutledge, NeWton, MA (US); Mao Wang, Belmont, MA (US); Allan Stuart Myerson, Boston, MA (US); Blair Kathryn Brettmann, Cambridge, MA (US); Nikhil Padhye, Cambridge, MA (US); Jung-Hoon Chun, Sudbury, MA (Us)

(73) Assignee: Massachusetts Institute of Technology, Cambridge, MA (US)

(21) App1.No.: 13/458,222

(22) Filed: Apr. 27, 2012

Related US. Application Data

(60) Provisional application No. 61/480,756, ?led on Apr. 29, 2011, provisional application No. 61/535,630, ?led on Sep. 16, 2011.

Publication Classi?cation

(51) Int. Cl. A61K 9/70 (2006.01) B29C 59/16 (2006.01) B29C 39/00 (2006.01)

(52) US. Cl. ........................ .. 156/227; 264/299; 264/447

(57) ABSTRACT

Layer processing for pharmaceuticals, and related systems, methods, and articles are generally described. In some embodiments, ingestible pharmaceutical products (e.g., tab lets) can be formed by processing one or more layers contain ing a pharmaceutically active composition. For example, at least one layer containing a pharmaceutically active compo sition can be manipulated (e.g., folded, rolled, stacked, etc.) such that the average thickness of the product formed by the manipulation is at least about tWo times the average thickness of the portions of the layer(s) used to form the product. In some embodiments, after the layer is manipulated, it can be processed (e. g., cut, coated, etc.) to form a ?nal product such as, for example, a tablet.

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