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E r s o z e t a ] . ( 4 3 ) P u b . D a t e : Dec. 2 2 , 2011( 5 4 ) PHOTOSENSITIVE AMINOACID-MONOMER C08J / 2 8 ( 2 0 0 6 . 0 1 )

LINKAGE AND BIOCONJUGATION C 7K 1 / 1 0 7 ( 2 0 0 6 . 0 1 )APPLICATIONS IN LIFE SCIENCESAND C07D 2 0 9 / 2 0 ( 2 0 0 6 . 0 1 )BIOTECHNOLOGY C 7C 2 3 5 / 7 8 ( 2 0 0 6 . 0 1 )C07C 3 2 3 / 5 9 ( 2 0 0 6 . 0 1 )( 7 5 ) I n v e n t o r s : Arzu E r s o z ; E s k i s e h i r ( T R ) ; D e n i z A61P 5 / 0 0 ( 2 0 0 6 0 1 )

H u r ; E s k i s e h i r ( T R ) ; F i l i z Y i l m a z ; C07F 1 7 / 0 0 ( 2 0 0 6 0 1 )E s k i s eh i r ( T R ) ; A d i l D e n i z l i ; B05D 5 / 0 6 ( 2 0 0 6 0 1 )E s k i s e h i r ( T R ) ; A y c a t i l i r O z c a n , B 8 2 Y 4 0 / 0 0 ( 2 0 1 1 . 0 1 )E s k i s e h i r ( T R ) ; S i b e l Emir 3 8 2 1 5 / 0 0 ( 2 0 1 1 0 1 )D i l t e m i z ; E s k i s eh i r ( T R ) ; S u z a n B82Y 5 / 0 0 ( 2 0 1 1 . 0 1 )Y f z a r E s l i l s e h . ( T R ) ; Qzlem ( 5 2 ) us . l . . . . . . . . 4 2 4 / 9 4 3 ; 4 2 7 / 1 5 7 ; 4 2 7 / 2 1 4 ; 4 3 5 / 7 . 2 3 ;B 1 e " > E . S k 1 S e P 1 r < T R > ; . s b e l 4 3 5 / 1 8 ; 4 3 5 / 1 9 ; 4 3 5 / 2 5 ; 4 3 5 / 2 8 ; 4 3 5 / 2 9 ;B y k t y a k . 1 E S k 1 . S e h 1 F ( T R ) ; 4 3 5 / 1 8 8 ; 4 3 6 / 5 0 1 ; 4 3 6 / 8 6 ; 5 2 2 / 8 7 ; 5 3 0 / 3 6 4 ;R u s t e m K e c l h E . s k l s ? h ( T R ) ; 5 3 0 / 3 8 0 ; 530/391 1 ; 5 3 0 / 3 9 1 . 3 ; 5 3 0 / 4 0 0 ;Gun" . a k " : E S k 1 S ? h 1 r . ( T R ) ; 5 3 0 / 4 0 8 ; 5 3 0 / 4 0 9 ; 5 4 8 / 4 9 6 ; 5 6 2 / 4 4 5 ; 5 6 2 / 5 5 6 ;T u g b a F m d k E S k 1 S e h 1 r ( T R ) 2 0 4 / 1 5 7 . 7 5 ; 2 0 4 / 1 5 7 . 7 1 ; 9 7 7 / 7 4 6 ; 9 7 7 / 7 7 3 ;

( 7 3 ) A s s i g n e e z R i d v a n s a y E s k i s e h i r ( T R ) 9 7 7 / 8 4 7 ; 9 7 7 / 8 9 6 ; 977/915; 977/920; 9 7 7 / 8 1 0( 2 1 ) A p p l . N o . : 1 3 / 2 0 3 , 8 3 3 ( 5 7 ) ABSTRACT

T h i s i n v e n t i o n i s r e l a t e d t o p r e p a r a t i o n o f p h o t o s e n s i t i v e( 2 2 ) PCT i l e d : D e c - 1 1 : 2009 r u t h e n i u m b a s ed a m i n o a c i d monomers and o l i g o m e r s ; a m i

n o a c i d m o n o m e r - p r o t e i n c r o s s - l i n k i n g u s i n g p h o t o s e n s i t a t( 8 6 ) PCT N0 5 PCT/IB2009/055707 i o n and c o n j u g a t i o n on m i c r o and a n o - s t r u c t u r e s by r u t h e

n i u m - c h e l a t e based monomers. I t s v a s t r a n g e b i o t e c h n o l g y 3 7 1 ( 6 ) 0 ) a p p l i c a t i o n s o f m u l t i f u n c t i o n a l ; b i o c o m p a t i b l e ; s t a b i l E a n d( 2 ) ( 4 ) D a t e : A u g 2 9 2 0 1 1 s p e c i ? c m i c r o a n d n a n o b i o - c o n j u g a t e s ; W h i c h W i l l s t a n d_ _ _ _ alone or simultaneously enable i ) both puri?cation and deterP u b h c a t l o n C l a s s l ? c a t l o n m i n a t i o n ; i i ) b o t h a r g e t i n g a n d i m a g i n g a n d t h e r a n o s t i c s a n d

( 5 1 ) I n t , C l , ( i i i ) c a t a l y s i s a n d d e t e r m i n a t i o n . The c o n s t r u c t i o n a n dA 6 1 K 8 / 4 4 ( 2 0 0 6 0 1 ) method f r e p a r a t i o n s a p p l i c a b l e t o s i l i c a m a t e r ia l s ; s u p e rB05D 7 / 0 0 ( 2 0 0 6 0 1 ) p a r a m a g n e t i c p a r t i c l e s ; Q D s ; C N T s ; A g / A u n a n o p a r t i c l e sG 0 1N 3 / 5 6 6 ( 2 0 0 6 0 1 ) a n d A u u r f a c e s a n d p o l y m e r i c m a t e r ia l s . The h o t o s e n s i t i v eC 1 2 Q 1 / 3 4 (200601) a m i n o a c i d monomer l i n k e r s can r e a ct v i a c h e m i c a l l y andC 1 2 Q 1 / 4 4 (200601) b i o c o m p a t i b l e o a o t o f i f f e r e n t m i c r o a n d n a n o - s u r f a c e a n dC 1 2 Q 1 / 2 6 ( 2 0 0 6 0 1 ) t h e n o t h e p r o t e i n When h e y c t a s a s i n g l e - s t e p c r o s s - l i n k i n gC12Q 1 / 2 8 ( 2 0 0 6 0 1 ) r e a c t i o n u s i n g i r r a d i a t i o n . T h e p h o t o s e n s i t i v e c o n j u g a t i o nC12Q / 0 2 (200601) based on c l i c k b i o c h e m i s t r y can be c a r r i e d o u t a t mild conC 1 2N / 9 6 ( 2 0 0 6 0 1 ) d i t i o n s ; i n d e p e n d e n t o f pH a n d t e m p e r a t u r e ; W i t h o u t a f f e c tG 0 1N 1 / 7 5 ( 2 0 0 6 0 1 ) i n g c o n f o r m a t i o n a n d f u n c t i o n o f r o t e i n .

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