Updated: 21Nov2016

CURRICULUM VITAE

Steven Scott Segal

PERSONAL

Birthplace: Miami, Florida

Married: Catharine A. Mouton

Residence: Columbia, Missouri USA

PROFESSIONAL CONTACT INFORMATION

Steven S. Segal, Ph.D.

Department of Medical Pharmacology and Physiology

One Hospital Drive - MA415 Medical Science Building

University of Missouri - Columbia

Columbia, MO 65212 USA

Tel: 573-882-2553 Fax: 573-884-4276

Email: segalss@health.missouri.edu

Web: http://medicine.missouri.edu/mpp/faculty-segal-s.html

http://dalton.missouri.edu/investigators/segalss.php

CURRENT FACULTY POSITIONS

06/01/2006: Professor of Medical Pharmacology and Physiology (MPP), University of Missouri

06/01/2006: Adjunct Professor of Medicine, University of Missouri – Columbia

07/24/2006: Investigator, Dalton Cardiovascular Research Center, Columbia MO

04/10/2007: Adjunct Professor of Biomedical Sciences, University of Missouri – Columbia

06/01/2009: Adjunct Professor in Biological Engineering, University of Missouri – Columbia

PREVIOUS FACULTY POSITIONS

07/01/1987 - 6/30/1992: Assistant Prof. of Applied Physiology, Noll Physiological Research Center

Pennsylvania State University, University Park, PA

07/01/1992 - 6/30/1997: Associate Professor of Epidemiology and Public Health, Yale University.

07/01/1992 - 6/31/1999: Associate Fellow, The John B. Pierce Laboratory, Inc. (tenured, 1992) &

Associate Professor of Cellular and Molecular Physiology, Yale School of

Medicine (tenured, 1997)

07/01/1999-05/31/2006: Fellow, The John B. Pierce Laboratory, Inc.

07/01/1999-05/31/2006: Professor of Cellular and Molecular Physiology, Yale School of Medicine

07/01/2000-05/31/2006: Adjunct Professor of Molecular, Cellular, and Developmental Biology, Yale

07/01/2003-05/31/2006: Adjunct Professor of Biomedical Engineering, Yale University

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EDUCATION

Bachelor of Arts: University of California, Berkeley (awarded 06/1976)

Field of Study: Physical Education

Master of Arts: University of California, Berkeley (awarded 08/1978)

Field of Study: Exercise Physiology

Doctor of Philosophy: University of Michigan, Ann Arbor (awarded 08/1984)

Fields of Study: Kinesiology (Education) and Physiology (dual degree)

Postdoctoral: University of Virginia, Charlottesville (07/1984 - 08/1987)

Field of Study: Physiology (Microcirculation)

RESEARCH SUPPORT

Active

R37 HL041026; National Institutes of Health/NHLBI (Segal, PI; MERIT Award)

Title: "Intercellular Coordination of Blood Flow Control"

Project Period: 09/01/2008-02/28/2019

Role: Principal Investigator

R01 HL-122608; National Institutes of Health/NHLBI (Davis MJ, PI)

Title: “Conduction within and along the lymphatic vascular wall”

Project Period: 01/01/15 - 12/31/18

Role: Co-Investigator

Completed (last 3 years)

R01 HL086483; National Institutes of Health/NHLBI (Segal, PI)

Title: "Microcirculation in Aging Skeletal Muscle"

Completed Project Period: 09/01/2007-11/30/2014

MENTORED RESEARCH SUPPORT

Erika M. Boerman, Ph.D.

Active

K99 HL129196-01A1 (Boerman, PI); NIH/NHLBI; Pathway to Independence Award

Title: Role of perivascular nerves and vascular dysfunction in inflammatory bowel disease

Project Period: 04/01/2016 – 03/31/2021 Role: Sponsor

Completed (last 3 years)

13POST16260012 (Boerman, PI): American Heart Association Postdoctoral Fellowship

Title: Aging and neurovascular regulation of endothelial cell calcium signals, in vivo.

Project Period: 07/01/2013 – 12/01/2013 Role: Sponsor

(Award returned upon receipt of F32 Fellowship)

F32 HL118836 (Boerman, PI); NIH/NHLBI Individual Postdoctoral NRSA

Title: Aging and neurovascular regulation of endothelial cell calcium signals

Project Period: 12/01/2013 – 11/31/2015 Role: Sponsor

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Shenghua Y. Sinkler, M.S.

Completed

15PRE22840000 (Sinkler, PI); American Heart Association Predoctoral Fellowship

Title: Rapid Onset Vasodilation with Advanced Age: Roles of Adrenergic and Endothelial Signaling

Project Period: 01/01/112015 - 12/31/2015

Role: PhD Candidate; dissertation research

Charmain Fernando, M.S.

Pending

American Heart Association Predoctoral Fellowship

Title: Capillary Perfusion and Vasomotor Control in Regenerating Skeletal Muscle

Project Period: 07/01/2016 - 06/30/2018

Role: PhD Candidate; dissertation research

PROFESSIONAL SOCIETIES (and committees served)

American Association for the Advancement of Science (1984 -2006)

American College of Sports Medicine (1977-2006)

American Heart Association

Council on Circulation (1987 - present)

Vascular Wall Biology Research Study Committee (1992-1995)

Abstract Referee, Scientific Sessions (2005)

American Physiological Society (1985 - present)

Committee for Liaison with Industry (1991-1994)

Mentor, APS/NIDDK Minority Travel Fellowship Program (1990-1996)

Education Committee (1997-2000)

Awards Committee, Cardiovascular Section (2003-2007; Committee Chair, 2004-2007)

American Society for Pharmacology and Experimental Therapeutics (2013 - present)

European Society for Microcirculation (1990 - present)

The Microcirculatory Society, Inc. (1985 - present)

Planning Committee, 1991-1992 & 1995-1998

Membership Committee, 1992; Councilor, 2000-2003

Nominations Committee (Chair), 2004-2007

President-Elect (04/07-04/08); President (04/08-04/09); Past-President (04/2009-04/2010)

Abstract Editor, Fall 2009 Meeting

North American Vascular Biology Organization (NAVBO; 1994 – present)

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HONORS AND AWARDS

Departmental Citation for Outstanding Undergraduate Achievement, UC Berkeley (06/1976)

Predoctoral Fellowship in Physiology, University of Michigan School of Medicine (09/1981-06/1983)

Predoctoral Fellowship in Kinesiology and Physiology, University of Michigan Rackham School of

Graduate Studies (09/1983-06/1984)

Postdoctoral Fellowship in Physiology, National Institutes of Health (07/1984-06/1987)

Fellow, American College of Sports Medicine (ACSM; 04/1989)

Travel Award for Outstanding Young Investigators, the Microcirculatory Society, Inc. (MCS; 04/1990)

Mary P. Wiedeman World Congress Travel Award, MCS (08/1991)

Abbott Microcirculation Award, European Society for Microcirculation (07/1992)

Fellow, Cardiovascular Section, American Physiological Society (03/1996)

Plenary Lecture in Basic Science, Southeast Chapter, American College of Sports Medicine (01/1997)

Established Investigator Award, American Heart Association (07/1993-06/1998)

Fellow, Council on Basic Cardiovascular Sciences, American Heart Association (04/2001)

President of the Microcirculatory Society, Inc. USA (Term: 2008-2009)

Margaret Proctor Mulligan Professorship in Medical Research, University of Missouri (04/2008)

Method to Extend Research in Time (MERIT) Award, NHLBI, NIH (10/2008 – 02/2019)

MCS Gerritsen Award for most cited review article (04/2010)

Opening Plenary Lecture for ACSM’s Integrative Physiology of Exercise (09/2010; Miami Beach)

Malpighi Award, European Society for Microcirculation (07/2013; Birmingham, UK)

Chancellor’s Professor of Research Excellence, University of Missouri (09/2013)

Excellence in Trainee Research Mentoring Award, Univ. Missouri School of Medicine (11/2015)

Eugene M. Landis Award, the Microcirculatory Society, Inc. (04/2016; San Diego)

Distinguished Alumni Lecture, Molecular and Integrative Physiology, University of Michigan (11/2016)

MEETINGS ORGANIZED

Winter Retreat of the Microcirculatory Society, Inc. Council

University of Missouri, Columbia (01/31/2009)

Fall meeting of the Microcirculatory Society, Inc.

University of Missouri, Columbia (10/16-17/2009)

Meeting Planning Committees

Integrative Biology of Exercise, American Physiological Society (09/08; Hilton Head, SC)

Vascular Biology 2013: Joint meeting of the MCS & NAVBO (10/2013; Cape Cod, MA)

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SYMPOSIA ORGANIZED (The title of presentation within a session is given where applicable)

American Physiological Society (04/1995, Atlanta, GA):

“Cellular and Molecular Signals Governing Energy Transduction During Exercise.”

American College of Sports Medicine (05/1996, Cincinnati, OH):

“Molecular Biology and Systems Physiology: Building the Bridge.”

7th World Congress for Microcirculation (08/2001; Sydney):

“Cell-to-Cell Coupling in Resistance Networks”

American Physiological Society (10/2004, Austin, TX): Integrative Biology of Exercise:

“Mechanical Forces and Signal Transduction in Vascular Remodeling”

American Physiological Society – Experimental Biology (04/2006, San Francisco, CA):

“Neurovascular Interactions”

Presentation: “Somatic and Sympathetic Neurovascular Interactions in Skeletal Muscle”

FASEB Summer Research Conference on Smooth Muscle (07/2006, Snowmass, CO):

“Cell to Cell Communication”

Presentation: “Neurovascular Interactions and Blood Flow Control”

American College of Sports Medicine Conference on Exercise Physiology (09/2006, Indianapolis, IN)

“Microvascular Control of Skeletal Muscle Blood Flow”

Presentation: “Cell to cell signaling during blood flow control in resistance networks”

American Physiological Society - Experimental Biology (5/2007, Washington, DC)

“The Vascular Supply During Aging” (Featured Topic)

Presentation: “Microvascular Aging and Blood Flow Control”

American Physiological Society (09/2008, Hilton Head, SC):

“Integrative Biology of Exercise: Regulation of Peripheral Resistance”

European Society for Microcirculation (08/2008, Budapest, Hungary)

“Intercellular Signaling in the Control of Vascular Resistance”

MCS President’s Symposium and Workshop (04/2009, New Orleans, LA)

“Live Cell Imaging of the Microcirculation: New Frontiers for Intravital Microscopy”

American Physiological Society – Experimental Biology (04/2011, Washington, DC): “Coupling blood

flow to metabolic demand: New insights and perspectives” (Featured Topic)

Presentation: “Blood flow regulation through adrenergic modulation of intercellular signaling”

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INVITED PARTICIPATION IN SYMPOSIA / CONFERENCES

American Heart Assoc. Scientific Sessions on Circulation and Basic Science (02/1986; Keystone, CO).

American Physiological Society, Cardiovascular Section (03/1986; St. Louis, MO).

The Microcirculatory Society, Inc. (03/89; New Orleans, LA).

International Congress of Physiological Sciences (07/1989; Helsinki, Finland).

Quaker Oats Sports Medicine Review Board (06/1991; Bermuda).

The Netherlands Physiological Society (12/1991; Papendal).

The Microcirculatory Society, Inc. (04/1992; Long Beach, CA).

Gordon Research Conference on Vascular Cell Biology (06/92; Colby Sawyer, NH).

American Physiological Society: Integrative Biology of Exercise (09/1992; Colorado Springs, CO).

American Heart Assoc.Workshop: Vascular Biology in Hypertension (09/1993; San Francisco, CA).

American College of Sports Medicine, National Meeting (06/1994; Indianapolis, IN).

Gaylord/Yale-New Haven Rehabilitation Center (09/94; New Haven, CT).

American College of Sports Medicine, New England Chapter (11/1994; Boxborough, MA).

American College of Sports Medicine, National Meeting (06/1995; Minneapolis, MN).

American College of Sports Medicine, Basic Science Specialty Conference (9/1995; Indianapolis, IN).

Copenhagen Muscle Research Centre, Conf.: Muscle Metabolism and Blood Flow (11/1995; Denmark).

Sixth World Congress for Microcirculation: Neurogenic Control Mechanisms (08/1996, Munich).

Nagano Symposium on Sports Science (10/1997; Matsumoto, Japan)

American College of Sports Medicine, National Meeting (06/1999; Seattle, WA)

Acta Physiologica Scandinavica Conf.: Oxygen Utilization in Skeletal Muscle (08/1999; Copenhagen)

American Assoc. of Anatomists: Cell-Cell Interactions in the Vessel Wall (04/2000; San Diego, CA)

FASEB Summer Conference on Smooth Muscle (07/2000; Snow Mass, CO)

American Physiological Society: EDHF: Chemical Nature and Sites of Action (04/2001; Orlando, FL)

8th International Symposium on Mechanisms of Vasodilatation (06/2001; Boston, MA)

7th World Cong. for Microcirculation: Vascular Connectivity & Function (08/2001; Sydney, Australia)

7th World Congress for Microcirculation: Microcirculation in Exercise (08/2001; Sydney, Australia)

Myogenic 2002 Centennial: Integration of Myogenic & Endothelial Mechanisms (06/2002; Stowe, VT)

14th World Congress of Pharmacol.: Regulation of Vascular Contractility (07/2002; San Francisco, CA)

International Society for Heart Research: Mechanisms of Vascular Control (07/2002; Madison, WI)

Microcirculatory Society: 50th Anniversary Symposium (04/2004, NIH, Bethesda, MD)

Gordon Research Conference: Brain Energy Metabolism & Blood Flow (8/2004; Colby College, ME).

“Coordinating blood flow control through cell-to-cell signaling”

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XXXV International Congress of Physiological Sciences Symposium Session (04/2005; San Diego, CA)

“Coordinating Interactions between Endothelium and Smooth Muscle”

American College of Sports Medicine Conference on Exercise Physiology (9/2006, Indianapolis, IN)

“Capillary Recruitment During Exercise: Where Are We Now?”

Dalton Cardiovascular Research Center, University of Missouri-Columbia (3/2007; Columbia, MO)

“Cellular Communication Within the Vascular Wall”

The Physiological Society: Ion Channels and the Microcirculation (03/2007; Belfast)

“Endothelium-dependent signalling pathways underlying conducted vasodilation”

Featured Topic: Cardiovascular Section, American Physiological Society (04/2008; San Diego, CA)

“Intercellular Calcium Signaling in the Vasculature"

European Society for Microcirculation (08/2008; Budapest, Hungary):

“Calcium Signaling in Microcirculation”

Danish Royal Academy of Sciences: August Krogh Symposium (06/2010; Copenhagen, Denmark):

“Regulation of Microcirculatory Flow: Conducted Vasodilation”

International Society of Resistance Arteries (05/2011; Rebild Bakker, Denmark)

“Intercellular Signaling Along Resistance Artery Endothelium”

Physiological Soc. 2012 (07/2012, Edinburg, Scotland; Session: Blood Flow Regulation: From Rest to

Maximal Exercise) “Spreading the Signal for Vasodilation”

Joint meeting of the British Microcirculation Society and The Microcirculatory Society, Inc. USA

(07/2012; Oxford, England) “Intercellular Coordination of Blood Flow Control”

Symposium celebrating the 20th Anniversary of the Robert M. Berne Cardiovascular Research Center,

University of Virginia (11/2012; Charlottesville, VA) “Neuromodulation of Cell-to-Cell Signaling

In Resistance Networks”

ASPET Symposium, Experimental Biology 2013 (04/2013; Boston, MA)

Symposium: Local Ca2+ signals in the endothelium: Key regulators of vascular function &

dysfunction: “Multiple Roles of Endothelial Ca2+ Signaling in Resistance Networks”

American Society for Hypertension Conference (05/2013; San Francisco, CA)

Symposium: “Vascular Wall Signaling: “Intercellular Coupling and Neuromodulation of Signaling”

International Gap Junction Conference Keynote Lecture (07/2013; Charleston SC)

“Intercellular Coordination of Blood Flow Control: Modulation by Aging & Neuroeffector Signaling"

Malpighi Award, European Society for Microcirculation Plenary Lecture (07/2013; Birmingham, UK)

“Integration and Modulation of Intercellular Signalling Underlying Blood Flow Control”

Vascular Biology 2013 Plenary Lecture (10/2013; Cape Cod, MA)

“Integrating and Modulating Intercellular Signaling Underlying Blood Flow Control”

“Abschiedssymposium” for H. Hoppeler (11/2013; University of Bern, Switzerland)

Presentation: “Coupling Microvascular Perfusion to Motor Unit Recruitment”

Honoring the legacy of Brian R. Duling (06/2014; University of Virginia)

Presentation: “Honoring the legacy of Brian R. Duling”

National Institute on Aging: Geroscience Workshop on Vascular Aging (11/2016; New Orleans)

Presentation: “Microvascular Mechanisms Underlying Compromised Blood Flow with Advanced Age”

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INVITED SEMINARS: National

Texas A&M University, Department of Medical Physiology (10/89).

Johns Hopkins University, Department of Bioengineering (11/89).

Lovelace Medical Foundation, University of New Mexico (03/91).

University of California, Berkeley, Department of Physical Education (04/92).

University of California, Los Angeles, Division of Cardiology (06/93).

New York Medical College, Department of Physiology (11/94).

SUNY, Syracuse, Department of Physiology (04/95).

University of Chicago, Department of Pathology (05/95).

SUNY, Stonybrook, Department of Physiology & Biophysics (03/96).

Brown University, Division of Biology and Medicine, Section of Physiology (05/96).

University of Colorado, Department of Kinesiology (09/96)

Albert Einstein College of Medicine (02/97)

University of North Texas Health Sciences Center (05/98)

University of Massachusetts, Department of Exercise Science (10/98)

American Heart Association, Heritage Affiliate (11/98)

University of Michigan, Department of Physiology (03/99)

Western Michigan University, Department of Biological Sciences (03/99)

University of Vermont, Department of Pharmacology (10/99)

University of Miami, Department of Surgery & Ryder Trauma Center (10/99)

University of Missouri, Department of Physiology (12/99)

University of Virginia, Department of Molecular Physiology and Biological Physics (05/00)

University of Arizona, Department of Physiology (10/00)

New York Medical College, Department of Physiology (09/01)

Medical College of Wisconsin, Department of Physiology (08/02)

New Jersey University of Medicine and Dentistry, Department of Pharmacology & Physiology (03/03)

Baylor College of Medicine, DeBakey Heart Center (5/03)

University of Texas Southwestern, Department of Internal Medicine (05/03)

Western Michigan University, Department of Biological Sciences (11/03)

Marquette University, Department of Biological Sciences (11/04)

University of Missouri, Department of Pharmacology and Physiology (12/04)

Cornell University, Department of Biomedical Sciences (12/05)

Michigan State University, Department of Toxicology and Pharmacology (06/08)

Rush University, Department of Molecular Biophysics Physiology (10/08)

University of Missouri, Department of Biological Engineering (05/09)

University of Virginia, Department of Molecular Physiology and Biophysical Science (05/09)

National Heart Lung and Blood Institute, National Institutes of Health (07/09)

Case Western University, Department of Physiology and Biophysics (12/09)

University of Colorado Boulder, Department of Integrative Physiology (03/11)

University of New Mexico, Department of Biochemistry and Molecular Biology (10/11)

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University of South Alabama, College of Medicine Distinguished Scientist Seminar (11/12)

“Neuromodulation of Intercellular Signaling along Vascular Resistance Networks”

Tulane University, Department of Pharmacology seminar series (01/11/2013)

“Intercellular Signaling in Resistance Networks: Modulation by Perivascular Nerves”

Oregon Health & Science University (03/04/2013)

“Cell-to-Cell Signaling Coordinates Blood Flow Control in Microvascular Resistance Networks”

Washington University St. Louis (04/03/2014)

“Coordination of Blood Flow Control through Intercellular Signaling in Microvascular Networks”

West Virginia University, Betschart Symposium Keynote Lecture (05/14/2014)

“Intercellular Signaling Underlying Blood Flow Control in Microvascular Resistance Networks”

University of Kansas, Kansas City, KS (10/05/2014)

“Blood Flow Control in Microvascular Resistance Networks: Organization, Integration and Modulation”

Georgia Regents University, Augusta, GA (11/18/2014)

“Modulation of Intercellular Signaling during Advanced Age: Manifestations in Microvascular

Resistance Networks”

University of Tennessee Health Sciences Center, Memphis, TN (11/20/2014)

“Modulation of Intercellular Signaling during Advanced Age: Manifestations in Microvascular

Resistance Networks”

University of California San Diego – Neuroscience (09/28/2015)

“Modulating Intercellular Signaling Underlying Blood Flow Control: Roles for Nerves and

K+ Channels”

University of Missouri - Biological Sciences (10/28/2015)

“Mechanisms Underlying Neuromodulation of Blood Flow Control”

Colorado State University (05/06/2016)

“Neuromodulation of Blood Flow Control”

University of Vermont, Burlington – Pharmacology (06/09/2016)

“Complementary Roles for Channels, Gaps and Holes in Vasomotor Control”

University of Michigan, Ann Arbor – Molecular and Integrative Physiology (11/02/2016)

“Intercellular Signaling Underlying Blood Flow Control: Integrated Roles for Channels,

Gaps and Holes”

INVITED SEMINARS: International

University of Birmingham, England (07/89).

University of Limburg, Maastricht, The Netherlands (11/90).

University of Dusseldorf, Germany (11/90).

University of Geneva, Switzerland (12/90).

University of Birmingham, England (12/90).

Saint Mary's Medical School, London, England (12/90).

University of Guelph, Ontario, Canada (02/92).

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The Flinders University of South Australia, Adelaide (03/94).

The University of Tasmania, Hobart (03/94).

University of Copenhagen, Denmark (11/95; 8/99)

Panum Institute, Copenhagen, Denmark (08/99)

John Curtin School of Medical Research, Australian National University, Canberra (08/01)

Slovak Academy of Sciences, Bratislava (8/08)

Aarhus University Institute of Physiology and Biophysics, Denmark (05/11)

University of Calgary, Smooth Muscle Research Group & Hotchkiss Brain Institute (10/11)

Strathclyde University, Glasgow, Scotland (07/12)

University of Western Ontario, London, Ontario, Canada (04/16/2015)

WORKSHOPS & ADVISORY PANELS

American College of Sports Medicine, Advisory Panel on: “Integration of Molecular Biology and

Systems Physiology” (1994-1995)

National Institute of Aging: “Changes in Skeletal Muscle Blood Flow with Aging and Disease” (1998)

Third Workshop on Endothelial Derived Hyperpolarizing Factor, (Paris; 6/00)

Mechanisms of Vasodilatation (Scientific Committee: Boston; 6/01)

TUTORIALS

American Physiological Society: "Integrative Biology of Exercise" (09/00; Portland, ME).

Topic: Control of the Muscle Circulation

New England American College of Sports Medicine, Annual Conference (11/00; Providence, RI)

Topic: Skeletal Muscle and its Vascular Supply

SABBATICALS & VISITING SCIENTISTS SPONSORED

Mikio Nakao, Ph.D., Osaka University of Economics, Japan (1991-1992)

Colin J. Carati, Ph.D., Flinders University of South Australia (1996)

Timothy O. Neild, Ph.D., Flinders University of South Australia (1996; 1998)

Caryl E. Hill, Ph.D., Australian National University (2002)

Swapnil Sonkusare, Ph.D., University of Virginia (2015)

Robert S. Mazzeo, Ph.D., University of Colorado – Boulder (2016)

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POSTDOCTORAL FELLOWS SPONSORED

Debra A. Lewis, Ph.D. (1989-1991)

David T. Kurjiaka, Ph.D. (1993-1995)

Donald G. Welsh, Ph.D. (1993-1997)

Jill E. Hungerford, Ph.D. (1997-1999)

Iain Bartlett, Ph.D. (1997-2000)

Jurgen vanTeeffelen, Ph.D. (1997-2000)

Robin Looft-Wilson, Ph.D. (2001-2004)

Geoffrey W. Payne, Ph.D. (2001-2004)

Shawn E. Bearden, Ph.D. (2001-2004)

Miriam De With, M.D. (2003-2004)

Johan F. Brekke, Ph.D. (2003-2006)

Torben R. Uhrenholt, M.D., Ph.D. (2005-2006)

Dwayne N. Jackson, Ph.D. (2005-2006)

Pooneh Bagher, Ph.D. (2007-2011)

Matthew J. Socha, Ph.D. (2009-2014)

Erik J. Behringer, Ph.D. (2009-2014)

Erika B. Westcott, Ph.D. (2011-2016)

Charles E. Norton III, Ph.D. (2015-present)

STUDENTS SUPERVISED/MENTORED

Doctor of Philosophy (Institution, discipline, year awarded)

Donna A. Williams (Pennsylvania State University; Physiology, 1991)

David T. Kurjiaka (Pennsylvania State University; Exercise and Sport Science, 1993)

Geoffrey G. Emerson (Yale University, MD/PhD; Cellular and Molecular Physiology, 2000)

Glenis J. Crane (Flinders University; Physiology, 2000; Primary Mentor: T.O. Neild)

Sara J. Haug (Yale University; Biomedical Engineering, 2004)

Timothy L. Domeier (Yale University, Cellular and Molecular Physiology, 2006)

Alex W. Moore (University of Missouri, Biomedical Sciences; 2010)

Shenghua Yuan Sinkler (University of Missouri, Medical Pharmacology and Physiology; 2016)

Charmain Fernando (University of Missouri, Medical Pharmacology and Physiology; in progress)

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Masters of Science (Institution, discipline, year awarded)

Herbert G. Chew, Jr. (Pennsylvania State University; Exercise and Sport Science, 1989)

Mary Ann Ledvina (Pennsylvania State University; Physiology, 1992)

Jane M. Pierzga (Pennsylvania State University; Physiology, 1992)

Rohit K. Puri (Pennsylvania State University; Bioengineering, 1993)

Tonya L. Jacobs (University of Hartford; Neuroscience, 1998)

Curt R. Canine (University of Missouri, Medical Pharmacology and Physiology; 2010)

Undergraduate (Institution, major, year completed)

Geoffrey G. Emerson (Yale University, Chemical Engineering, 1995)

Susan C. Cunningham (Yale University, Psychobiology; 1996)

Guillem Gonzalez-Lomas (Yale University, Biomedical Engineering, 1999)

Ashley Campion (Yale University, Biomedical Engineering 2001)

Alia Chisty (Yale University, Molecular, Cellular, and Developmental Biology, 2003)

David Chu (Yale University, Biomedical Engineering, 2004)

Alexander W. Lohman (University of Missouri, Biology, 2010)

Samantha M. Bixby (University of Missouri, Nutritional Sciences, 2011-2012)

Cale J. Roberts (University of Missouri, Biology, 2012-2013)

Jesse E. Everhart (University of Missouri, Biochemistry, 2013-2014)

Justin T. Whitfield (University of Missouri, Biochemistry, 2013-2015)

Ariél Gill (University of Missouri, Biology, 2015-2016)

Aaron Pangan (University of Missouri, Biological Engineering, 2016- )

GRADUATE STUDENT THESIS COMMITTEES SERVED

Meredith Jaye Stevenson (Medical Pharmacology and Physiology; 2007-2009: M.S., 2009)

Josh Scallan (Medical Pharmacology and Physiology; 2006-2010: Ph.D., 2010)

Erika Boerman Westcott (MSU, Toxicology and Pharmacology: 2006-2010; Ph.D. 2010)

Seth Fairfax (MU, Medical Pharmacology and Physiology: 2010-2012; Ph.D., 2012)

Alexander Lohman (University of Virginia: Doctorate – external member; completed 2014)

Baraa Al-Khazraji (Univ. Western Ontario: Medical Biophysics – external thesis reviewer 04/2015)

Seth Holwerda (MU, Medical Pharmacology and Physiology: PhD, 2015)

Kim To (MU, Medical Pharmacology and Physiology: Doctorate in progress)

Laura Schaad (University of Bern: Institute of Anatomy – external thesis reviewer, 08/2016)

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JUNIOR FACULTY MENTOR/ADVISOR

Maike Krenz, M.D. (2008-2015)

Timothy L. Domeier, Ph.D. (2010-present)

Camila Manrique, M.D. (2011-present)

Matthew J. Socha, Ph.D. (2014-2015)

Erik J. Behringer, Ph.D. (2014-2015)

Erika M. Boerman, Ph.D. (2016-present)

TEACHING

University of Missouri

Lecturer

“Microcirculatory Function: MPP 9434” (V. Huxley, Course Instructor; semi-annual)

“Skills in Biomedical Research: MPP 8420” (G. Sowa, Course Instructor; semi-annual)

“Multidisciplinary Approaches: V_BSCI 8087” (D. Bowles, Course Instructor; semi-annual)

“Patient Based Learning” (M2 Block 7 Tutor; School of Medicine; annual)

“Medical Physiology” (M1 Lectures: Circulation Biophysics; Capillary Fluid Balance; annual)

Prior institutions

Yale University

- Course Developer and Head Instructor, "Physiological Systems" 1996-2006, (cross listed: Biological

Engineering, Molecular and Cellular Developmental Biology; Molecular and Cellular Physiology).

- Conference Section Leader, "Medical Physiology 500b" (1992-1999).

Pennsylvania State University

- Graduate Course Instructor: "Mammalian Physiology 571" (1987-1992).

University of Michigan

- Graduate Exercise Physiology: Teaching Assistant + Class lectures (1979-1981)

- Medical Student (M1) Conference Leader: 1981-1982

- Instructor/Trainer: Weight/circuit training, racquetball (1979-1981)

University of California, Berkeley

- Exercise Physiology Laboratory: Teaching Assistant (1977-1978)

- Instructor/Trainer: Swimming, weight/circuit training, racquetball, badminton (1977-1978)

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INSITUTIONAL RESPONSIBILITIES & COMMITTEES

University of Missouri (2006-present)

Member, Faculty Review Committee, MU SOM (12/2014 – present)

Member, Task force on Clinical Research, MU SOM (03/2013 – present)

Chair, Search Committee for Assistant Professor (tenure-track) in MPP (06-07/2012)

Fellow, Interdisciplinary Center on Aging (08/2011 – present)

Member, Doctoral Faculty: MPP (06/2006 – present); Biomedical Sciences 04/2007 – present)

Member, School of Medicine Space Committee (07/2010 – 06/2014)

Member, MPP Promotion and Tenure Committee (07/2010 – present)

Member, MPP Doctoral Faculty Committee (11/2013 – present)

Member, Obstetrics, Gynecology and Women’s Health Promotion and Tenure Committee (07/2011)

Chair, Search Committee for Research Assistant Professor in MPP (05/2010 – 07/2010)

Member, Subcommittee for Departmental Post Tenure Review Policy (02/2007).

Chairman, Postdoctoral Guidelines Committee (07/2007 – present)

MPP (Medical Pharmacology and Physiology) Space Committee (02/2007 – present)

Molecular Biology Core Facility in MPP (02/2007 – present: design and oversight)

MPP Research Incentive Fund (RIF) Committee (03/2007 – present)

Member, MPP/Nutritional Science Search Committee (11/2007 – 10/2008)

Member, MPP Program Assessment Committee (2008)

MPP Faculty Candidate interviews

MPP Postdoctoral Fellows: individual meetings/interviews (2 – 4 per year)

MPP Graduate Students: individual meetings/interviews (2 – 3 per year)

Faculty Seminar Speakers hosted (1-2 per year)

The John B. Pierce Laboratory (1992-2006)

Institutional Animal Care and Use Committee (1992 – 2005; Chair, 1995 – 2002)

Advisory/Planning Committee to the Director (1995 – 2005)

Search Committee for the Director (1999)

Chair, Search Committee for senior position in Pulmonary Biology (2002)

Chair, Search Committee: Metabolism and Blood Flow (2005)

Yale University (1996-2006)

Course Director: Physiological Systems (see: TEACHING): 1996 – 2003 ( Lecturer: 1996 – 2006)

Gatorade Internship and Lecture Program at Yale: 1997 - 2001 (Chair, 1998 – 2001)

Graduate Education Committee, Department of Cellular and Molecular Physiology (2000 – 2006)

Steering Committee: Vascular Biology and Transplantation Program (2002 – 2006)

Steven Scott Segal

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EDITORIAL & REFEREE EXPERIENCE

Editorships

Journal of Physiology: Reviewing Editor (2014 – present)

Microcirculation: Associate Editor (2004 – 2011)

Abstracts Editor: Fall 2009 meeting of the Microcirculatory Society, Inc. “Frontiers in Microcirculation:

Control Processes and Clinical Applications” Microcirculation 16: 749-780, 2009

Editorial Boards

American Journal of Physiology: Heart and Circulatory Physiology (1993 – present).

Journal of Applied Physiology (1989 – 2001)

Journal of Physiology (2014 – present)

Journal of Vascular Research (1999 – present)

Microcirculation (1999-2011)

Manuscript Referee

Acta Physiologica; American Journal of Physiology; Arteriosclerosis, Thrombosis, and Vascular

Biology (ATVB); British Journal of Pharmacology; Cell Calcium; Circulation Research; Experimental

Physiology; Hypertension; European Journal of Physiology; FASEB Journal; Journal of Applied

Physiology; Journal of Clinical Investigation; Journal of Physiology; Journal of Vascular Research;

Microcirculation; Proceedings of the National Academy of Sciences, Nature, Scientific Reports.

Grant Reviews & Study Sections

American Heart Association (National Center): Committee on Vascular Cell Biology (1992 – 1995).

Allegheny-Singer Research Institute, Ad-hoc (1992 – 1993).

American Institute of Biological Science, Ad-hoc (1988).

Biomedical Research Support Grant Program, Penn State Univ. (1989-1992; Chairman, 1991-92).

British Heart Foundation (2007 - present); Canadian Foundation for Innovation (2000 – 2006)

Canadian Institute of Health Research (2006 – 2012)

Donaghue Women’s Health Investigator Program at Yale (1998 – 2003)

National Institutes of Health:

Hypertension & Microcirculation (HM, ad hoc) (2005 – 2006)

Bioengineering Partnership SEP (2007)

Challenge Grants SEP/SRG/10 ZRG1 VH-D (58) (2009)

AICS SEP/SRG /05 ZRG1 VH-B (02) (2012)

CSR IAM meeting 2015/01 ZAI1 TT-M (J1) 1 (2014)

Swiss National Science Foundation (1998 – 2006); Wellcome Trust (1996 - 2010)

Steven Scott Segal

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External Referee for Promotion and Tenure

Australian National University (05/2001)

Baylor College of Medicine (05/2011)

Boston University (09/1993; 08/2006)

Colorado State University (08/2015)

Cedars-Sinai Medical Center (06/2012)

Eastern Virginia Medical School (06/2012)

Flinders University of South Australia (11/2000; 10/2001)

Medical College of Georgia (07/1998)

New York Medical College (03/2005)

Ohio University (10/2002)

State University of New York (01/2004)

Texas A&M University (10/1997)

Tulane University (08/2011; 12/2013)

University of Arizona (02/1997; 08/2010)

University of Birmingham, England (05/00)

University of California Davis (07/2014)

University of California Los Angeles, School of Medicine (06/2012)

University of Copenhagen, Denmark (07/1998)

University of Illinois at Chicago (10/1997)

University of Missouri Kansas City, School of Medicine (08/2012)

University of Southern California (12/1999, 09/2000)

University of Texas Southwestern (03/2005)

University of Toronto, Canada (10/2007; 12/2013)

University of Vermont (07/2002, 10/2014)

University of Virginia (07/2002; 10/2008; 08/2011; 08/2014)

Virginia Commonwealth University (10/2004)

Western University, Schulich School of Medicine & Dentistry, Ontario, Canada (08/2012; 08/2014)

West Virginia University (10/06; 11/2010)

Yale University (03/2009)

York University, Ontario, Canada (11/2003, 9/2014)

Steven Scott Segal

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PUBLICATIONS

Refereed Journal Articles

1. Segal SS and Brooks GA. Effects of glycogen depletion and work load on post-exercise O2

consumption and blood lactate. J Appl Physiol 47: 514-521, 1979. PMID: 533743

2. White TP, Villanacci JF, Morales PG, Segal SS and Essig DA. Exercise-induced adaptations of rat

soleus muscle grafts. J Appl Physiol 56: 1325-1334, 1984. PMID: 6725089

3. Segal SS and Faulkner JA. Temperature-dependent physiological stability of rat skeletal muscle in

vitro. Am J Physiol Cell Physiol 248: C265-C270, 1985. PMID: 3976876

4. Essig DA, Segal SS and White TP. Skeletal muscle protein synthesis and degradation in vitro:

effects of temperature. Am J Physiol Cell Physiol 249: C464-C470, 1985. PMID: 4061630

5. Segal SS, White TP and Faulkner JA. Architecture, Composition, and contractile properties of rat

soleus muscle grafts. Am J Physiol Cell Physiol 250: C474-C479, 1986. PMID: 3953809

6. Segal SS, Faulkner JA and White TP. Skeletal muscle fatigue in vitro is temperature dependent.

J Appl Physiol 61: 660-665, 1986. PMID: 3745058

7. Segal SS and Duling BR. Communication between feed arteries and microvessels in hamster

striated muscle: segmental vascular responses are functionally coordinated. Circ Res 59: 283-290,

1986. PMID: 3769148

8. Segal SS and Duling BR. Flow control among microvessels coordinated by intercellular

conduction. Science 234: 868-870, 1986. PMID: 3775368

9. Segal SS and Duling BR. Propagation of vasodilation in resistance vessels of the hamster:

development and review of a working hypothesis. Circ Res 61 (5 Pt 2): II20 - II25, 1987. PMID: 3664984

10. Segal SS, Damon DN and Duling BR. Propagation of vasomotor responses coordinates arteriolar

resistances. Am J Physiol Heart Circ Physiol 256: H832-H837, 1989. PMID: 2923241

11. Segal SS and Duling BR. Conduction of vasomotor responses in arterioles: a role for cell-to-cell

coupling? Am J Physiol Heart Circ Physiol 256: H838-H845, 1989. PMID: 2923242

12. Keller MW, Segal SS, Kaul S and Duling BR. The behavior of sonicated albumin microbubbles

within the microcirculation: a basis for their use during myocardial contrast echocardiography.

Circ Res 65: 458-467, 1989. PMID: 2752551

13. Segal SS. Microvascular recruitment in hamster striated muscle: role for conducted vasodilation.

Am J Physiol Heart Circ Physiol 261: H181-H189, 1991. PMID: 1858919

14. Lewis DA, Loomis JL and Segal SS. Preservation of endothelial cells in excised rat carotid arteries:

effects of transmural pressure and segment length. Circ Res 69: 997-1001, 1991. PMID: 1934349

15. Williams DA and Segal SS. Microvascular architecture in rat soleus and extensor digitorum longus

muscles. Microvasc Res 43: 192-204, 1992. PMID: 1584061

16. Segal SS and Bény J-L. Intracellular recording and dye transfer in arterioles during blood flow

control. Am J Physiol Heart Circ Physiol 263: H1-H7, 1992. PMID 1636748

17. Segal SS, Kurjiaka DT and Caston AC. Endurance training increases arterial wall thickness in rats.

J. Appl. Physiol. 74: 722-726, 1993. PMID: 8458788

18. Williams DA and Segal SS. Feed artery role in blood flow control to rat hindlimb skeletal muscles.

J Physiol 463: 631-646, 1993. PMC1175363

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19. Pierzga JM and Segal SS. Spatial relationships between neuromuscular junctions and microvessels

in hamster cremaster muscle. Microvasc Res 48: 50-67, 1994. PMID: 7990723

20. Puri RK and Segal SS. Microvascular responses to body tilt in the cutaneous maximus muscle of

conscious rats. J Appl Physiol 77: 2426-2433, 1994. PMID: 7868465

21. Welsh DG and Segal SS. A holder and calibration chamber for micropressure measurements.

Microvasc Res 48: 403-405, 1994. PMID: 7731401

22. Nakao M and Segal SS. Muscle length alters geometry of arterioles and venules in hamster

retractor. Am J Physiol Heart Circ Physiol 268: H336-H344,1995. PMID: 7840281

23. Kurjiaka DT and Segal SS. Interaction between conducted vasodilation and sympathetic nerve

activation in hamster cremaster arterioles. Circ Res 76: 885-891, 1995. PMID: 7729006

24. Ledvina MA and Segal SS. Sarcomere length and capillary curvature of rat hindlimb muscles in

vivo. J Appl Physiol 78: 2047-2051, 1995. PMID: 7665398

25. Kurjiaka DT and Segal SS. Conducted vasodilation elevates flow in arteriolar networks of hamster

striated muscle. Am J Physiol Heart Circ Physiol 269: H1723-H1728, 1995. PMID: 7503270

26. Kurjiaka DT and Segal SS. Autoregulation during pressor response elevates wall shear rate in

arterioles. J Appl Physiol 80: 598-604, 1996. PMID: 8929604

27. Welsh DG and Segal SS. Muscle length directs sympathetic nerve activity and vasomotor tone in

resistance vessels of hamster retractor. Circ Res 79: 551-559, 1996. PMID: 8781488

28. Segal SS and Neild TO. Conducted depolarization in arteriole networks of the guinea-pig small

intestine: effect of branching on signal dissipation. J Physiol 496.1: 229-244, 1996. PMC1160839

29. Emerson GG and Segal SS. Alignment of microvascular units along skeletal muscle fibers of

hamster retractor. J Appl Physiol 82: 42-48, 1997. PMID: 9029196

30. Welsh DG and Segal SS. Coactivation of resistance vessels and muscle fibers with acetylcholine

release from motor nerves. Am J Physiol Heart Circ Physiol 273: H156-H163, 1997. PMID: 9249486

31. Chew HG and Segal SS. Arterial morphology and blood volumes of rats following 10-14 weeks of

tail suspension. Med Sci Sports Exercise 29: 1304-1310, 1997. PMID: 9346160

32. Fuglevand AJ and Segal SS. Simulation of motor unit recruitment and microvascular unit

perfusion: spatial considerations. J Appl Physiol 83: 1223-1234, 1997. PMID: 9338432

33. Welsh DG and Segal SS. Endothelial and smooth muscle cell conduction in arterioles controlling

blood flow. Am J Physiol Heart Circ Physiol 274: H178-H186, 1998. (cover illustration) PMID: 9458866

34. Rudic DR, Shesely EG, Maeda N, Smithies O, Segal SS and Sessa WC. Direct evidence for the

importance of endothelium-derived nitric oxide in vascular remodeling. Clin Invest 101: 731-736,

1998. PMC508619

35. Welsh DG, Jackson WF and Segal SS. Oxygen induces electromechanical coupling in arteriolar

smooth muscle cells: a role for L-type Ca2+ channels. Am J Physiol Heart Circ Physiol 274:

H2018-H2024, 1998. PMID: 9841528

36. Walker BD and Segal SS. Role of smooth muscle activation in conduction of vasodilation along

isolated hamster feed arteries. J Vasc Res 35: 405-412., 1998. PMID: 9858865

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37. Segal SS, Welsh DG and Kurjiaka DT. Spread of vasodilatation and vasoconstriction in feed

arteries and arterioles of hamster skeletal muscle. J Physiol 516.1: 283-291, 1999. PMC2269203

38. Segal SS, Brett SE and Sessa WC. Co-distribution of NOS and caveolin throughout peripheral

vasculature and skeletal muscle of hamsters. Am J Physiol Heart Circ Physiol 277: H1167-H1177,

1999. PMID: 10484439

39. Grasby DJ, Morris JL and Segal SS. Heterogeneity of vascular innervation in hamster cheek pouch

and retractor muscle. J Vasc Res 36: 465-476, 1999. PMID: 10629422

40. Emerson GG and Segal SS. Endothelial cell pathway for conduction of hyperpolarization and

vasodilation along hamster feed artery. Circ Res 86: 94-100, 2000. PMID: 10625310

41. Hungerford JE, Sessa WC and Segal SS. Vasomotor control in arterioles of the mouse cremaster

muscle. FASEB J. 14: 197-207, 2000. PMID: 10627294

42. Bartlett IS and Segal SS. Resolution of smooth muscle and endothelial pathways for conduction

along hamster cheek pouch arterioles. Am J Physiol Heart Circ Physiol 278: H604-H612, 2000. PMID: 10666093

43. VanTeeffelen JWGE and Segal SS. Effect of motor unit recruitment on functional vasodilatation in

hamster retractor muscle. J Physiol 524.1: 267-278, 2000. PMC2269846

44. Jacobs T L and Segal SS. Attenuation of vasodilatation with skeletal muscle fatigue in hamster

retractor. J Physiol 524.3: 929-941, 2000. PMC2269900

45. Welsh DG and Segal SS. Role of EDHF in conduction of vasodilation along hamster cheek pouch

arterioles in vivo. Am J Physiol Heart Circ Physiol: 278: H1832-H139, 2000. PMID: 10843879

46. Rudic RD, Bucci M, Fulton D, Segal SS and Sessa WC. Temporal events underlying arterial

remodeling after chronic flow reduction in mice: correlation of structural changes with a deficit in

basal nitric oxide synthesis. Circ Res 86: 1160-1166, 2000. PMID: 10850968

47. Emerson GG and Segal SS. Electrical coupling between endothelial cells and smooth muscle cells

in hamster feed arteries: role in vasomotor control. Circ Res 87: 474-479, 2000. PMID: 10988239

48. Segal SS, Cunningham SA and Jacobs TL. Motor nerve topology reflects myocyte morphology in

hamster retractor and epitrochlearis muscles. J Morphol 246: 103-117, 2000. PMID: 11074578

49. Bartlett IS, Crane GJ, Neild TO and Segal SS. Electrophysiological basis of arteriolar vasomotion

in vivo. J Vasc Res 37: 568-575, 2000. PMID: 11146411

50. Emerson GG and Segal SS. Electrical activation of endothelium evokes vasodilation and hyper-

polarization along hamster feed arteries. Am J Physiol Heart Circ Physiol 280: H160-H167, 2001. PMID: 11123230

51. Segal SS and Jacobs TL. Role for endothelial cell conduction in ascending vasodilatation and

exercise hyperemia in hamster skeletal muscle. J Physiol 536.3: 937-946, 2001. PMC2278906

52. Emerson GG, Neild TO and Segal SS. Conduction of hyperpolarization along hamster feed

arteries: augmentation by acetylcholine. Am J Physiol Heart Circ Physiol 283: H102-H109, 2002. PMID: 12063280

53. Payne GW, Madri JA, Sessa WC and Segal SS. Abolition of arteriolar dilation but not constriction

to histamine in cremaster muscle of eNOS-/- mice. Am J Physiol Heart Circ Physiol 285: H487-

H492, 2003. PMID: 12689855

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54. VanTeeffelen JWGE and Segal SS. Interaction between sympathetic nerve activation and muscle

fibre contraction in resistance vessels of hamster retractor muscle. J Physiol 550.2: 563-574, 2003.

(with editorial) PMC2343056

55. Budel S, Bartlett IS and Segal SS. Homocellular conduction along endothelium and smooth muscle

of arterioles in hamster cheek pouch: unmasking an NO wave. Circ Res 93: 61-68, 2003. PMID: 12791708

56. Haug SJ, Welsh DG and Segal SS. Sympathetic nerves inhibit conducted vasodilatation along feed

arteries during passive stretch of hamster retractor muscle. J Physiol 552.1: 273-282, 2003. PMC2343307

57. Sandow SL, Looft-Wilson R, Doran B, Grayson TH, Segal SS and Hill CE. Expression of

homocellular and heterocellular gap junctions in hamster arterioles and feed arteries. Cardiovasc

Res 60:643-653, 2003. PMID: 14659810

58. Payne GW, Madri JA, Sessa WC and Segal SS. Histamine inhibits conducted vasodilation through

endothelium-derived NO production in arterioles of mouse skeletal muscle. FASEB J 18:280-286,

2004. PMID: 14769822

59. Looft-Wilson RL, Haug SJ, Neufer PD and Segal SS. Independence of connexin expression and

vasomotor conduction from sympathetic innervation in hamster feed arteries. Microcirculation

11:397-408, 2004. PMID: 15280065

60. Crane GJ, Neild TO and Segal SS. Contribution of active membrane processes to conducted

hyperpolarization in arterioles of hamster cheek pouch. Microcirculation 11: 425-433, 2004. PMID: 15280068

61. Looft-Wilson RC, Payne GW and Segal SS. Connexin expression and conducted vasodilation

along arteriolar endothelium in mouse skeletal muscle. J Appl Physiol 97:1152-1158, 2004. PMID: 15169746

62. Bearden SE, Payne GW, Chisty A and Segal SS. Arteriolar network architecture and vasomotor

function with ageing in mouse gluteus maximus muscle. J Physiol 561.2: 535-545. 2004. PMC1665363

63. Bearden SE and Segal SS. Microvessels promote motor nerve survival and regeneration through

local VEGF release following ectopic reattachment. Microcirculation 11:633-644, 2004. PMID: 15726831

64. Haug SJ and Segal SS. Sympathetic neural inhibition of conducted vasodilatation along hamster

feed arteries: Complementary effects of α1- and α2-adrenoreceptor activation. J Physiol 563.2:

541–555, 2005. PMC1665587

65. Bearden SE and Segal SS. Neurovascular alignment in adult mouse skeletal muscles.

Microcirculation 12:161–167, 2005. PMID: 15824038

66. Diep HK, Vigmond EJ, Segal SS and Welsh DG. Defining electrical communication in skeletal

muscle resistance arteries: A computational approach. J Physiol 568.1: 267–281, 2005. PMC1474767

67. deWith MCJ, Haug SJ, van der Heijden EPAB and Segal SS. Ischemia-reperfusion impairs

ascending vasodilation in feed arteries of hamster skeletal muscle. Microcirculation 12: 551–561,

2005. PMID: 16207628

68. Soderberg KA, Payne GW, Sato A, Medzhitov R, Segal SS and Iwasaki A. Innate control of

adaptive immunity via remodeling of lymph node feed arteriole. Proc Nat Acad Sci 102: 16315–

16320, 2005. PMC1283434

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69. VanTeeffelen JWGE and Segal SS. Rapid dilation of arterioles with single contraction of hamster

skeletal muscle. Am J Physiol Heart Circ Physiol 290: H119-H127, 2006. PMID: 16100250

70. Ford MC, Bertram JP, Hynes SR, Michaud M, Li Q, Young M, Segal SS, Madri JA, and Lavik

EB. A novel macroporous hydrogel for the co-culture of neural progenitor and endothelial cells to

form functional vascular networks in vivo. Proc Nat Acad Sci103: 2612-2617, 2006. (cover

illustration) PMC1413771

71. Brekke JF, Jackson WF and Segal SS. Arteriolar smooth muscle Ca2+ dynamics during blood flow

control in hamster cheek pouch. J Appl Physiol. 101: 307–315, 2006. PMID: 16455810

72. Domeier TL and Segal SS. Electromechanical and pharmacomechanical signaling pathways for

conducted vasodilatation along endothelium of hamster feed arteries. J Physiol 579.1:175-186,

2007. PMC2075370

73. Uhrenholt TR, Domeier TL and Segal SS. Propagation of calcium waves along endothelium of

hamster feed arteries. Am J Physiol Heart Circ Physiol 292: H1634-40, 2007. PMID: 17098832

74. Tallini YN , Brekke JF, Shui B, Doran R, Hwang S, Nakai J, Salama G, Segal SS, and Kotlikoff

MI. Propagated endothelial Ca2+ waves and arteriolar dilation in vivo: measurements in Cx40BAC–

GCaMP2 transgenic mice. Circ Res 101:1300-1309, 2007. PMID: 17932328

75. Hakim CH, Jackson WF and Segal SS. Connexin isoform expression in smooth muscle cells and

endothelial cells of hamster cheek pouch arteries and retractor feed arteries. Microcirculation

15(6):503-514, 2008. (Cover Illustration) PMC2761760

76. De With, M., A. De Vries, A. Kroese, B. Van der Heijden, R. Bleys, S. Segal and M. Kon.

Vascular anatomy of hamster retractor muscle facilitates allograft transplantation. Eur Surg Res

42:97-105, 2009. PMC2955737

77. Long JB and Segal SS. Quantifying perivascular sympathetic innervation: Regional differences in

C57BL/6 mice at 3 and 20 months. J Neurosci Meth184:124-128, 2009. PMC2761756

78. Long JB, Jay SM, Segal SS and Madri JA. VEGF-A and Semaphorin3A: Modulators of vascular

sympathetic innervation. Dev Biol 334:119-132, 2009. PMC2871302

79. Bertram JP, Williams CA, Robinson R, Segal SS, Flynn NT and Lavik EB. Intravenous hemostat:

nanotechnology to halt bleeding. Science Transl Med 1(11):11ra22, 2009. PMC2992987

80. Jackson DN, Moore AW and Segal SS. Blunting of rapid onset vasodilatation and blood flow

restriction in arterioles of exercising skeletal muscle with ageing in mice. J Physiol 588.12:2269-

2282, 2010. PMC2911225

81. Moore AW, Bearden SE and Segal SS. Regional activation of rapid onset vasodilatation in mouse

skeletal muscle: Regulation through α-adrenoreceptors. J Physiol 588.17:3321-3331, 2010. PMC2976025

82. Moore AW, Jackson WF and Segal SS. Regional heterogeneity of adrenoreceptor subtypes in

arteriolar networks of mouse skeletal muscle. J Physiol 588.21:4261-4274, 2010. PMC3002455

83. Bagher P, Duan D and Segal SS. Evidence for impaired neurovascular transmission in a murine

model of Duchenne Muscular Dystrophy. J Appl Physiol 110: 601-609, 2011. PMC3069623

84. Bagher P, Davis MJ and Segal SS. Intravital macrozoom imaging and automated analysis of

endothelial cell calcium signals coincident with arteriolar dilation in Cx40BAC GCaMP2 transgenic

mice. Microcirculation 18(4): 331–338, 2011. PMC3082596

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85. Bagher P and Segal SS. The mouse cremaster muscle preparation for intravital imaging of the

microcirculation. J Vis Exp 52: e2874, 2011. PMC3132939

http://www.jove.com/details.php?id=2874

86. Bagher P, Polo-Parada L and Segal SS. Microiontophoresis and micromanipulation for intravital

fluorescence imaging of the microcirculation. J Vis Exp 52: e2900, 2011. PMC3132940

http://www.jove.com/details.php?id=2900

87. Socha MJ, Hakim CH, Jackson WF and Segal SS. Temperature effects on morphological integrity

and Ca2+ signaling in freshly isolated murine feed artery endothelial cell tubes. Am J Physiol Heart

Circ Physiol 301:H773-H783, 2011. PMC3191091

88. Bagher P, Davis MJ and Segal SS. Visualizing calcium responses to acetylcholine convection along

endothelium of arteriolar networks in Cx40BAC GCaMP2 transgenic mice. Am J Physiol Heart

Circ Physiol 301:H794-H802, 2011. PMC3191093

89. Behringer EJ, Socha MJ, Polo-Parada L and Segal SS. Electrical conduction along endothelial cell

tubes from mouse feed arteries: Confounding actions of glycyrrhetinic acid derivatives. Brit J

Pharmacol 166:774-787, 2012. PMC3417504

90. Correa D and Segal SS. Neurovascular proximity in the diaphragm muscle of adult mice.

Microcirculation 19: 306–315, 2012. PMC3336045

91. Westcott EB, Goodwin EL, Segal SS and Jackson WF. Function and expression of ryanodine

receptors and inositol 1,4,5 trisphosphate receptors in smooth muscle cells of murine feed arteries

and arterioles J Physiol 590.8: 1849-1869, 2012. PMC3573308

92. Behringer EJ and Segal SS. Tuning electrical conduction along endothelium of resistance arteries

through Ca2+-activated K+ channels. Circ Res 110:1311-1321, 2012. PMC3467972

93. Socha MJ, Domeier TL, Behringer EJ and Segal SS. Coordination of intercellular Ca2+ signaling in

endothelial cell tubes of mouse resistance arteries. Microcirculation 19:715-770, 2012. (Cover

Illustration) PMC3502682

94. Westcott EB and Segal SS. Ageing alters perivascular nerve function of mouse mesenteric arteries

in vivo. J Physiol 591.5:1251-1263, 2013. PMC3607869

95. Behringer EJ, Shaw RL, Socha MJ, W and Segal SS. Aging impairs electrical conduction along

endothelium of resistance arteries through enhanced Ca2+-activated K+ channel activation. Arterio

Thromb Vasc Biol 33:1892-1901, 2013. PMC3769416

96. Turlo KA, Scapa J, Bagher P, Jones AW, Feil R, Korthuis RJ, Segal SS and Iruela-Arispe ML.

β1-integrin is essential for vasoregulation and smooth muscle survival in vivo. Arterio Thromb

Vasc Biol 33:2325-2335, 2013. PMC3882010

97. Socha MJ and Segal SS. Isolation of Microvascular Endothelial Tubes from Mouse Resistance

Arteries. J Vis Exp 81: e50759, 2013. http://www.jove.com/video/50759 PMC3992011

98. Hayoz S, Bradley V, Hayoz S, Bradley V, Boerman, EM, Nourian Z, Segal SS and Jackson WF.

Aging increases the size and spontaneous transient outward current amplitude of smooth muscle

cells from murine superior epigastric arteries. Am J Physiol Heart Circ Physiol 306: H1512–

H1524, 2014. PMC4042199

99. Domeier TL, Roberts CR, Gibson AK, Hanft LM, McDonald KS and Segal SS. Dantrolene

suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in

cardiomyocytes of aged mice. Am J Physiol Heart Circ Physiol 307: H818-H829, 2014. PMC4166750

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100. Sinkler SY and Segal SS. Aging alters reactivity of microvascular resistance networks in mouse

gluteus maximus muscle. Am J Physiol Heart Circ Physiol 307: H830-H839, 2014. PMC4166744

101. Socha MJ, Boerman EM, Behringer EJ, Shaw RL, Domeier TL and Segal SS. Advanced age

protects microvascular endothelium from aberrant Ca2+ influx and cell death induced by hydrogen

peroxide. J Physiol 593.9: 2155–2169, 2015. PMC4422569

102. Nance ME, Whitfield JT, Zhu Y, Gibson AK, Hanft LM, Campbell KS, Meininger GA, McDonald

KS, Segal SS, and Domeier TL. Attenuated sarcomere lengthening of the aged murine left

ventricle observed using two-photon fluorescence microscopy. Am J Physiol Heart Circ Physiol

309: H918-H925, 2015. PMID: 26209054 (PMC Journal – In Process)

103. Behringer EJ and Segal SS. Membrane potential governs calcium influx into microvascular

endothelium: Integral role for muscarinic receptor activation. J Physiol 293.20: 4531-4548, 2015. PMID: 26260126 (PMC Journal – In Process)

104. Boerman EM and Segal SS. Depressed perivascular sensory innervation of mouse mesenteric

arteries with advanced age. J Physiol 594.8:2323-2338, 2016. PMID: 26010764 (PMC Journal – In

Process)

105. Boerman EM, Everhart JE and Segal SS. Advanced age decreases local calcium signaling in

endothelium of mouse mesenteric arteries in vivo. Am J Physiol Heart Circ Physiol 310: H1091-

H1096, 2016. PMID: 26945073 (PMC Journal – In Process)

106. Fernando CA, Liu Y, Sowa G and Segal SS. Attenuated rapid onset vasodilation with greater force

production in skeletal muscle of caveolin-2-/- mice. Am J Physiol Heart Circ Physiol 311: H415-

H425, 2016. PMID: 27317631 (PMC Journal – In Process)

107. Sinkler SY, Fernando CA and Segal SS. Differential adrenergic modulation of rapid onset

vasodilatation along resistance networks of skeletal muscle in old versus young mice. J Physiol

PMID: 27501249 (accepted 07/27/2016) doi: 10.1113/JP272409

Manuscripts Submitted

Kapela A, Behringer EJ, Segal SS and Tsoukias N. Computational analysis of electrical conduction

along microvascular endothelial tubes and intact resistance arteries: Role of ion channel activation.

(Under revision)

Hayoz S, Pettis J, Bradley V, Segal SS, and Jackson WF. Increased amplitude of inward rectifier K+

currents with advanced age in smooth muscle cells of murine superior epigastric arteries. (Under

revision)

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Invited Reviews

1. Duling BR, Hogan RD, Langille BL, Lelkes P, Segal SS, Vatner SF, Weigelt H and Young MA.

Vasomotor control: functional hyperemia and beyond. Fed Proc 46: 251-263, 1987. PMID: 3542588

2. Segal SS. Communication among endothelial and smooth muscle cells coordinates blood flow

control during exercise. News Physiol Sci 7: 152-156, 1992.

3. Segal SS. Cell-to-cell communication coordinates blood flow control. Hypertension 23(6 Pt 2):

1113-1120, 1994. PMID: 8206602

4. Segal SS and Kurjiaka DT. Coordination of blood flow control in the resistance vasculature of

skeletal muscle. Med Sci Sports Exercise. 27: 1158-1164, 1995. PMID: 7476060

5. Segal SS. Integration of blood flow control to skeletal muscle: Key role of feed arteries. Acta

Physiol Scand 168: 511-518, 2000. PMID: 10759588

6. Thomas GD and Segal SS. Neural control of muscle blood flow during exercise. J Appl Physiol 97:

731-738, 2004. PMID: 15247201

7. Segal SS. Regulation of blood flow in the microcirculation. Microcirculation 12: 33-45, 2005. PMID: 15804972

8. Bagher P and Segal SS. Regulation of blood flow in the microcirculation: Role of conducted

vasodilation. Acta Physiol 202:271-284, 2011. PMC3115483

9. Socha MJ, Behringer EJ and Segal SS. Calcium and Electrical Signaling along Endothelium of the

Resistance Vasculature. Basic Clin Pharmacol Toxicol 110:80-86, 2012. PMC3271116

10. Behringer EJ and Segal SS. Spreading the signal for vasodilatation: Implications for blood flow

control and the effects of aging. J Physiol 590.24: 6277–6284, 2012. PMC3533190 (Cover

Illustration)

11. Westcott EB and Segal SS. Perivascular innervation: A multiplicity of roles in vasomotor control

and myoendothelial signaling. Microcirculation 20: 217-238, 2013. PMC3771679

12. Segal, SS. Integration and Modulation of Intercellular Signalling Underlying Blood Flow Control.

J Vasc Res 52:136-157, 2015. PMID: 26368324

Book Chapters

1. Buskirk ER and Segal SS. The aging motor system: Skeletal muscle weakness. In: Physical Activity

and Aging. American Academy of Physical Education, Papers No. 22, Human Kinetics Books,

Champaign, IL; 1989. pp. 19-36.

2. Duling BR, Matsuki T and Segal SS. Conduction in the resistance vessel wall: its contribution to

vasomotor tone and vascular communication. In: JA Bevan (ed.). The Resistance Vasculature;

Humana Press, Clifton, NJ; 1991. pp. 193-215.

3. Segal SS. Convection, diffusion, and mitochondrial utilization of oxygen during exercise. In: D

Lamb and C Gisolfi (eds.): Perspectives in Exercise and Sports Medicine (Vol. 5): Energy

Metabolism in Exercise and Sport. Brown and Benchmark, Carmel, IN; 1992. pp. 269-343.

4. Segal SS and Welsh DG. Interactions of muscle fibers and nerves with resistance vessels: Novel

implications for blood flow control. In: H Nose, T Morimoto, and E R Nadel (eds.): The 1997

Nagano Symposium on Sports Science. Cooper, Carmel, IN, 1998. pp. 67-82.

Steven Scott Segal

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5. Segal SS. Dynamics of microvascular control in skeletal muscle. In: B Saltin, R Boushel, N Secher,

and JH Mitchell (eds.): Exercise and the Circulation in Health and Disease. Human Kinetics,

Champaign, IL, 1999. pp. 141-153.

6. Segal SS. Localization and dispersion of oxygen demand and supply in skeletal muscle. In: J Roca,

R Rodriguez-Roisin, and PD Wagner (eds.): Pulmonary and Peripheral Gas Exchange in Health

and Disease. M. Dekker, New York, NY; 2000. pp. 383-407.

7. Segal SS, Emerson GG, and Bartlett IS. Endothelium and smooth muscle pathways for conduction

in resistance microvessels. In: PM Vanhoutte (ed.): EDHF 2000. Taylor & Francis, London, 2001.

pp. 22-31.

8. Segal SS and Bearden SE. Organization and Control of Circulation to Skeletal Muscle. In: Farrell

PA, Joyner MJ, Caiozzo VJ (eds.): Advanced Exercise Physiology. Lippincott, Williams and

Wilkins, Philadelphia; 2012. pp. 332-347 (Chapter 11). ISBN: 978-0-7817-9780.

9. Segal SS. Special Circulations. In: WF Boron and EL Boulpaep: Medical Physiology (3rd Ed).

Elsevier, Philadelphia, 2016. pp. 556-587. ISBN: 978-1-4557-4377-3

10. Segal SS. Exercise Physiology and Sports Science. In: Boron WF and Boulpaep EL: Medical

Physiology (3rd Ed). Elsevier, Philadelphia, 2016. pp. 1204-1222. ISBN: 978-1-4557-4377-3

11. Behringer EJ and Segal SS. Electrical conduction along endothelium of resistance arteries. In:

Levitan I and Dopico AM (eds.): Vascular Ion Channels in Physiology and Disease. Springer,

Switzerland; 2016. pp. 79-99 (Chapter 4). ISBN: 978-3-319-29633-3.

Editorials & Perspectives

1. Segal SS. Nitric oxide is present from incubated skeletal muscle preparations. J Appl Physiol 77:

2517-2518, 1994. PMID: 7896584

2. Segal SS and Jackson WF. Special edition of Microcirculation commemorating the 50th anniversary

of the Microcirculatory Society, Inc. Microcirculation 12: 1-4, 2005.

3. Segal SS. Frontiers in Microcirculation: Control Processes and Clinical Applications.

Microcirculation 17: 159–163, 2010. PMID: 20374480

4. Segal SS and Bagher P. Regulation of Myoendothelial Junction Formation: Bridging the Gap. Circ

Res 106: 1014-1016, 2010. PMC2865428

5. Segal SS. Blood flow restriction without sympathetic vasoconstriction in ageing skeletal muscle

during exercise. J Physiol 592.21:4607-4608, 2014. PMC4253463

5. Segal SS. Enhanced functional sympatholysis through endothelial signalling in healthy young men

and women. J Physiol (accepted 10/03/2016)

Letters to the Editor

1. VanTeeffelen JWGE and Segal SS. Rapid arteriolar vasodilation with single contractions in hamster

skeletal muscle. J Appl Physiol 99: 2451, 2005. (Response to Point-Counterpoint: “The muscle

pump is/is not an important determinant of muscle blood flow during exercise.”

2. Segal SS. The basics of capillary recruitment in skeletal muscle. (Invited response to Point-

Counterpoint: “There is/is not capillary recruitment during exercise.”) J Appl Physiol 104: 897,

2007 (Compendium of authors: 895-899).