Update Arg-ADNIGustavo E. Sevlever , Silvia Vázquez, Deborah R. Gustafson,

Salvador M. Guinjoan, Ricardo F. Allegri (*) and Arg-ADNI group.

Centro de Memoria y Envejecimiento

Instituto de Investigaciones Neurológicas (FLENI)Buenos Aires, Argentina

Buenos Aires, Nov 10, 2015*speaker

First patient / first visitQ1 2012

Last patient / last visitQ1 2013

First Year2013 / 2014

Arg-ADNIStudy Timeline

Month 302014 / 2015

Month 482016 / 2017

B

1

B

2,5

4 year

Arg-ADNIPatients’ Flowchart

Patients Screened at FLENINº= 60

Early MCINº=12

Healthy ControlsNº= 15

Late MCINº= 16

Dementia AD

Nº=13

Screening FailureNº= 7

Patients Screened to ADNINº= 108

2 Claustrophobia1 Psychiatric Disease 1 Cancer1 Adult ADHD2 without informant

Patients Followed (Baseline)

Nº= 56

DropoutNº= 3

2 removed inform.cons1 by distance/caregiver

Early MCINº=10

Healthy ControlsNº= 13

Late MCINº= 16

Dementia AD

Nº=12

Early MCINº=?

Healthy Controls

Nº= ?

Late MCINº= ?

Dementia AD

Nº=?

Patients Followed Month 12

Nº= 51

Patients Followed Month 48

Nº= ?

New Patients Invited to ADNI

Nº= 6

Early MCINº=6/10

Healthy Controls

Nº= 10/13

Late MCINº= 12/16

Dementia AD

Nº=4/12

Patients Followed Month 30Nº= 32/51

DropoutNº= 5

2 removed inform.cons2 Cancer1 Institutionalized

Screening / Baseline

%compl.

Month12

Month30

Month 48

Demographic data (+) 100% (+) (+) (+)

Clinical, NPS, NPSq (+) 100% (+) (+) (+)

Cognitive Reserve (MCI) (+) MCI

Blood (+) (+)

APOE (+) 100%

CSF AB42/Tau (+) 71% (+)

MRI (3T) (+) 100% (+) (+) (+)

FDG PET Scan (+) 95% (+)

PiB PET scan (+) 89% (+)

Tau PET scan (AVID) (+)

Arg-ADNISchedule

2016

Tau tracer (PETscan) in ADNI Cohort

• AVID (AV 1451)• Start-up: April 2016

Month 48

(+)

(+)

(+)

(+)

(+)

(+)

(+)

(+)

ADNI cohort (51ptes)

Demographic data

Clinical, NPS, NPSq

Cognitive Reserve (MCI)

Blood

APOE

CSF AB42/Tau

MRI (3T)

FDG PET Scan

PiB PET scan

Tau PET scan (AVID)

• National grant application (CONICET) • Start-up: Nov, 2015