unit-i: non-aromatic heterocyclic...

Unit-I: Non-Aromatic Heterocyclic Compounds.

Section-A: Each question carries 5 Marks:

1. Explain the ring opening reactions of azirines.

2. Explain Neber Rearrangement.

3. Explain the term strain with respect to azirine&aziridine.

4. Describe two methods for the generation of oxiranes.

5. Explain two ring opening reactions of thiirane.

6. How do you convert methyl oxirane to methyl thiirane.

7. Explain different types of strains.

8. Explain the structural factors affecting conformations of flexible

heterocyclics.

9. Explain the synthesis of Azirines from the following:

i. Vinyl azides ii. Isoxazoles.

10. Explain the synthesis of Aziridine from following:

i. Gabriel method ii. Wenker method

11. Explain Hassner method to synthesise Aziridine.

12. Explain the ring opening reactions of aziridines.

13. Explain the ring opening reactions of oxiranes.

14. Explain the synthesis of thiiranes.

15. Explain any two synthesis of thiranes from oxiranes

16. Write any two synthesis of Diazirines.

17. Explain the reactivity of Diazirines.

18. Explain the synthesis of Diaziridines.

19. Explain the reactivity of diaziridines.

18. Explain the synthesis of Oxaziridines.

19. Explain the reactivity of Oxaziridines.

20. Explain the synthesis of Azetidines.

21. Explain the synthesis of azetidines from aziridines.

22. Explain ring opening reactions of Azetidines.

23. Explain the synthesis of Oxetanes

21. Explain the synthesis of Oxetanes from oxiranes.

22. Explain ring opening reactions of Oxetanes.

23. Explain the synthesis of thietanes.

21. Explain the synthesis of thietanes from thiiranes&Oxiranes.

22. Explain the ring opening reactions of thietanes.

24. Complete the Following reactions.






Section-B: Each question carries 10 Marks:

1. a. Predict the products in the following reactions.

b. Write the synthesis and reactivity of thiiranes.

2. a. Explain the ring opening reactions of oxetanes.

b. Write the major product in the following reaction.

3. a. Explain the two ring opening reactions of Azirine&Diazirine.

b. Give the synthesis & reactivity of Oxetanes.

4. a. Give a method for synthesis of the following:

i. Thietane ii. Azetidine.

b. Explain the ring opening reactions of the following:

i. Thietane ii. Oxaziridine

5. a. Give a method for the synthesis of diaziridine&oxaziridine from a

common ketone.

b. Explain a method of synthesis for each of the following:

i. Oxaziridine ii. Oxiranes.

6. a. Predict the products in the following:

b. Explain the ring opening reactions of Azirines.

7. a. Explain different types of strains & interactions.

b. Explain the conformational aspects of non-aromatic heterocyclics .

8. a. Write the synthesis of Azirine&Aziridines.

b. Write about the ring opening reactions of Aziridines.

9. a. Explain the synthesis of aziridine by the following methods.

i. Gabriel Method ii. Cycloaddition.

b. Explain Neber rearrangement to prepare Azirine.

10.a. Complete the following reactions by predicting the products

b. Write any one synthesis of Oxirane, thiiranes&aziridine.

11.a. Explain Electrophilic &Nucleophilic Ring opening reactions of Oxiranes.

b. Write two synthesis of thiiranes from oxiranes.

12. a. Explain Desulphurization & photochemical reactions of Thiiranes.

b. Explain the formation of the following products:

13. a. Explain the reactivity of Diaziridines.

b. Explain thermal & photochemical rearrangement reactions of

Oxaziridines.

14. a. Explain the synthesis of Azetidines from following:

i. isoxazolines ii. γ-lactones

b. Explain the reactivity of azetidines.

15. a. Explain the synthesis of Oxetanes from Paternobuchii reaction.

b. Explain the synthesis of thietanes from oxiranes&thiiranes.

16. a. Explain the synthesis of thietanes from following:

i. 1, 3- dihalo alkanes ii. Cyclic carbonates.

b. Explain the ring opening reactions of Oxetanes.

17. a. Explain the formation of the Products:

b. Explain the reactivity of Thietanes.

UNIT-2: FIVE AND SIX MEMBERED HETEROCYCLES WITH TWO

HETERO ATOMS

SECTION –A (Each question carries 5 marks)

1. Describe the aromatic character of azoles?

2. Give the synthesis of barbutiric acid?

3. Imidazole is tautomeric explain?

4. Outline the synthesis of pyridazine

5. Give any one synthesis of pyrazole ring?

6. Write the products formed when nitro benzene reacts with 1,3butadiene?

7. Outline one method of the synthesis of imidazole and isothiazole?

8. Outline the synthesis of pyrazole?

9. Outline the synthesis of thiazole?

10. Outline the synthesis of oxazole?

11. Outline the synthesis of isoxazole?

12. Outline the synthesis of pyridazine?

13. Outline the synthesis of pyrimidine?

14. Outline the synthesis of pyrazine?

15. Outline the synthesis of oxazine?

16. Outline the synthesis of thiazine?

17. Explain the reactivity of imidazoles?

18. Explain the reactivity of thiazoles?

19. Explain the reactivity of pyrazoles?

20. Explain the reactivity of isothiazoles?

21. Explain the reactivity of oxazoles?

22. Explain the reactivity of isoxazoles?

23. Explain the reactivity of pyrazines?

24. Explain the reactivity of oxazines?

25. Explain the reactivity of thiazines?

26. Explain the reactivity of pyridazines?

27. Explain the reactivity of pyrimidines?

SECTION –B (Each question carries 10 marks)

1. a. Outline the importance and reactivity of pyrimidines?

b. Outline synthesis and reactivity of isoxazole

2. a. Outline one method of synthesis of pyrazine, isothiazole and thiazine?

b. Outline synthesis and reactivity of imidazole?

3. a. Outline the importance and reactivity of pyrazines?

b. Outline synthesis and reactivity of isothiazole?

4. a. Outline the importance and reactivity of pyridazines?

b. Outline synthesis and reactivity of pyrazole?

5. a. Outline the importance and reactivity of oxazole?

b. Outline synthesis and reactivity of thiazole?

6.a. Outline the importance and reactivity of pyrimidines?

b. Outline synthesis and reactivity of oxazole?

7. a. Outline the importance and reactivity of thiazine?

b. Outline synthesis and reactivity of pyrazines?

8. a. Outline synthesis and reactivity of pyrimidines?

b. Outline the reactivity of isothiazole?

9. a. Explain a method each for the synthesis of thiazoles and oxazoles from

α-halo ketones?

b. Write the products in the following reactions. Explain their mechanism?

10. a. Describe the aromatic of 1, 3 azoles and 1, 2 azoles?

b. Explain the aromatic character and reactivity of imidazole.

11. a. Describe the synthesis and reactivity of pyrazole?

b. Give the synthesis of the following compounds

1. Thiazoles 2. Pyrimidines

UNIT-3: HETEROCYCLES WITH MORE THAN TWO HETERO

ATOMS

SECTION –A (Each question carries 5 marks)

1. 1. Outline synthesis of 1,2,3-triazoles?

2. 2. What is a sydnone? Write any one synthesis of sydnone?

3. 3. Describe the synthesis of purine ring system from a pyrimidines

4. 4. Write the structure of any 2 purine bases and outline their synthesis?

5. 5. Describe the synthesis of 1,3,4-oxadiazoles and 1,3,4 thiadiazoles?

6. 6. Write the structures of caffeine, theobromine and theophylline?

7. 7. Outline synthesis of 1,2,4-triazoles?

8. 8. Outline synthesis of Tetrazoles?

9. 9. Outline synthesis of 1,2,4-oxadiazoles?



12. 12. Outline synthesis of 1,2,4-thiadiazoles?




16. 16. Outline synthesis of 1,2,3-triazines?



19. 19. Outline synthesis of tetrazines?

20. 20. Explain the synthesis and importance of purines?

21. 21. Explain the synthesis and importance of pteridines.

22. 22. Outline synthesis of Caffeine, theobromine and theophylline?

23. 23. Explain the aromatic character of triazoles?

24. 24. Explain the aromatic character of tetrazoles?

25. 25. Explain the aromatic character of oxadiazoles?

26. 26. Explain the aromatic character of thiadiazoles?

27. 27. Explain the aromatic character of triazines?

28. 28. Outline the reactivity of 1,2,3-triazoles?

29. 29. Outline the reactivity of 1,2,4-triazoles?

30. 30. Outline the reactivity of Tetrazoles?

31. 31. Outline the reactivity of 1,2,4-oxadiazoles?



34. 34. Outline the reactivity of 1,2,4-thiadiazoles?




38. 38. Outline the reactivity of 1,2,3-triazines?



41. 41. Outline the reactivity of tetrazines?

SECTION –B (Each question carries 10 marks)

1. a. Outline the importance and reactivity of 1,2,3-triazoles?

b. Outline synthesis and reactivity of 1,2,3-triazine?

2. a. Outline one method of synthesis of 1, 2, 4-triazoles, Tetrazoles, 1, 2, 4-

oxadiazole?

b. Outline synthesis Caffeine, theobromine and theophylline?

3. a. Outline the importance and reactivity of 1,3,4-thiadiazoles?

b. Outline synthesis and reactivity of 1,3,5-triazines?

4. a. Outline the importance and reactivity of 1,2,5-oxadiazoles?

b. Outline synthesis and reactivity of tetrazines?

5. a. Outline the importance and reactivity of 1,3,4-oxadiazoles?

b. Outline synthesis and reactivity of 1,2,4triazines?

6. a. Outline the importance and reactivity of 1,2,4-oxadiazole ?

b. Outline synthesis and reactivity of Tetrazoles?

7. a. Outline the importance and synthesis of purines?

b. Outline synthesis and reactivity of 1,2,4triazines?

8. a. Outline synthesis and importance of pteridines?

b. Outline the synthesis and reactivity of 1,2,5- thiadiazoles ?

9. a. Outline synthesis and importance of 1,2,4- thiadiazoles?

b. Outline the synthesis and reactivity of 1,2,3- thiadiazoles ?

10. a. Outline the synthesis and importance of caffeine and theobromine?

b. Give the synthesis of 1,2,5oxadiazoles and 1,2,5 thiadiazoles?

11. a. Explain synthesis and reactivity of tetrazines

b. Give the synthesis of 1,2,4triazoles and 1,2,4 oxadiazoles

12. a .Outline the synthesis and reactivity of 1,2,4 triazoles

b. Explain the synthesis & reactivity of Pyraozole

13. a.Write the synthesis of following:

1. Caffiene 2. Theophylline 3.Pteridine

b. Write the synthesis of Purines&Pyrimidines

14. a. Outline the synthesis of Adenine and Guanine from

purine ring system?

b. Discuss the synthesis and reactivity of tetrazoles?

15. a. Outline the synthesis each for i)1,2,3triazoles ii) 1,3,4 oxadiazoles

b. Write the aromatic character & importance of 1,2,4-triazines

Unit-IV: Larger Ring & Other Heterocyclic compounds

Section-A: Each question carries 5 Marks:

1. Outline the synthesis of benzoxepines.

2. Give the synthesis of Selenophenes.

3. How do you prepare ethyl - azepin-1-carboxylate? Explain its formation.

4. Give a method for the synthesis of Azonine&Borole.

5. Give the synthesis of Phospholes&Tellerophenes.

6. How many isomeric monocyclic diazepines are there? Write the structures of

all possible tautomers of 1,2-diazepines.

7. Write any one synthesis of Azepine&oxepine.

8. Write the reactivity of Azepines.

9. Write the synthesis & reactivity of Oxepines.

10. Write synthesis & reactivity of thiepines.

11. Write one synthesis of Benzodiazepines &Benzoazepines.

12. Write one synthesis of Benzoxepine&Benzothiepine.

13. What are Azocines? Write any one synthesis.

14. Predict the products for the following reactions.

15. Predict the products for the following reactions.

16. Complete the following reactions:

17. Write one synthesis of 1, 2 –diazepines, 1,3 –diazepines& 1,4-diazepines

18. Explain the valence bond isomerization to synthesize Azepines.

19. Complete the following reactions.

20. Write the reactivity of diazepines.

Section-B: Each question carries 10 Marks:

1. a. Write the synthesis & reactivity of oxepines

b. Write the rearrangement reactions of diazepines.

2. a. Write the synthesis & reactivity of azepines.

b. Write the synthesis of Selenophenes, Tellerophenes&Phospholes.

3. a. Discuss the rearrangement reactions of 1,2-diazepines.

b. Identify the products obtained in the following reactions:

4. a. What are Boroles. Give any two methods for the synthesis of boroles.

b. Discuss the synthesis of the following:

i. Azocine ii. Oxepine.

5.a. Write the synthesis & reactivity of Azepines.

b. Give one synthesis for the following compounds.

i. Benzoxepine ii. Azonine

6.a. Discuss the synthesis & reactivity of Oxepines.

b. Predict the products in the following reactions.

7. a. Write the synthesis of Benzoazepine, Benzoxepines&Benzothiepines.

b. Write the synthesis of Azonines&Azocines.

8. a. Write the synthesis & reactivity of Azepines.

b. Write about phospholes. Write any two synthesis.

9. a. Write the synthesis & reactivity of Oxepines.

b. Write about Boroles. Write any two synthesis.

10.a. Write the synthesis & reactivity of Thiepines.

b. Write about selenophenes. Write any two synthesis.

11.a. Write the synthesis & reactivity of diazepines.

b. Write about Tellerophenes. Write any two synthesis.

12.a. Complete the following reactions.

b. Predict the Products for the following reactions.

unit-i: non-aromatic heterocyclic...

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