Unique Water-Soluble Propolis

www.uniquebiotech.co.kr

World Best & Unique Propolis Specialist

1. 회사소개1. Company Overview

July 3, 2012: Founded the company

July 13, 2012: Registered its factory

October 19, 2012: Obtained a license as a feed manufacturer in Chungcheongbuk-doNovember 26, 2012: Chosen as an agriculture industry–commerce convergence small- and medium-sized enterprise (SME) by the Ministry of Agriculture, Food and Rural Affairs (MAFRA)

June 21, 2013: Selected as a venture company by the Small & Medium Business Corporation

February 7, 2014: Registered as an item by the Public Procurement Service

February 25, 2014: Obtained a certification for its research and development (R&D) center from

the Ministry of Science, ICT and Future Planning

May 13, 2015: Certified as a start-up and jump-up company by the Chungbuk Creative

Economy Innovation Center

May 27, 2015: Obtained the license as a health functional food manufacturer from the Ministry

of Food and Drug Safety (MFDS)

November 10, 2016: Entered the food production and processing industry of Yeongdong-gun

July 1, 2017: Selected as a promising SME by the Ministry of SMEs and Startups

History

Certification of New Excellent Technology from the MAFRA

Certification of New Excellent Technology No. 32-029

Certifications

ISO 9001 New Excellent Technology

Patent Inventions

The manufacturing method of water-soluble propolis (No. 0550165 in Korea and No. 4113520 in Japan)

The fractions and manufacturing method of propolis, which is effective against acne and wrinkles, with

an improved fragrance (No. 10-1216113)

Patent Registrations

Livestock and fish farming feed additive preparation method with fortified polyphenol using grape by-

products and propolis extracts (No. 10-1273425)

Livestock and fish farming feed additives preparation device using grape by-products and propolis

extracts (No. 10-1458882)

The manufacturing method of eco-friendly, alcohol-free, and water-soluble propolis (No. 10-1403511)

The manufacturing method of eco-friendly, alcohol-free, and water-soluble propolis using natural honey

(No. 10-1661495)

The manufacturing method of a high-content and water-soluble propolis spray (No. 10-1765455)

International Patent Application

The manufacturing method of eco-friendly, alcohol-free, and water-soluble propolis using natural honey

(PCT/KR2016/007859)

Patents

Awards

November 2003: Received the Administrator’s Award from the

Small & Medium Business Administration

November 2007: Won the Minister’s Award of Science and

Technology at the Korea Entrepreneurial Startup Business Fair 2007

February 2008: Received a citation from the Ministry of Health

and Welfare

March 2008: Received a letter of appreciation from the MFDS

May 2013: Obtained a citation from the MFDS

December 2015: Received a citation from the president of the

Small & Medium Business Administration’s Chungcheongbuk-do

regional office

Awards

Main Career

2007–2009: Chairman of the Korea Health Industry Development Institute’s health functional food code amendment subcommittee2009–2012: Chairman of the phenol subcommittee of the MFDS’ health functional food code improvement committee2008–2009: Member of the Korea Food & Drug Administration (KFDA)’s regulatory reform committee2009–2012: Chairman of the Korea Health Supplements Association (KHSA)’s distribution advancement committee2008–2012: Member of the KHSA’s policy committee2007–2009: Member of the KFDA’s health functional food development council and system code improvement committeePresent: CEO of Unique Biotech Co., Ltd.

Director of The Apicultural Society of Korea(ASK)Secretary-general of the World Propolis Science Forum(WPSF) Vice president of the Korea Propolis Research Association(KPRA)

Yong-Kap Hur, Chief Executive Officer (CEO) of Unique Biotech Co., Ltd.

※ Conducted about 20 R&D propolis projects that were supported by the government※ Presented 19 academic researches of propolis in Korea and foreign countries

2. 프로폴리스 소개

2. Propolis Introduction

Propolis is a substance made by honeybees by combining their secretions with the resin they collect from plants to prevent the propagation of germs and decomposition in beehives.

Its main functional components are flavonoid compounds and phenol compounds such as quercetin, artepillin C, cinnamic acid, coumarin acid, caffeic acid, and others. Propolis is a natural antibiotic with physiologically active functions such as antioxidant effects, antibacterial functions, anti-inflammation capabilities, and immunity enhancement.

What Is Propolis?

Return to a beehive. Mix resin with secretion.

Apply propolis in a beehive.

Wax

MineralsPollen

Essential Oils

Resin

Propolis

The Story of Propolis

How propolis was discovered is an interesting story.

One day, while exploring the Amazon rainforest, a scholar accidently observed

a field mouse intruding into a beehive to go after honey. Upon seeing their

home being invaded, hundreds of bees surrounded the mouse and

simultaneously attacked it with bee strings that eventually killed it.

A few months later, the scholar passed by the same site and looked into the

beehive to find the dead mouse still there and undecomposed. This made the

scholar curious, and he closely observed the carcass to find some sticky

substance applied all over it. He found out later on that the substance was

called propolis.

Although successful in killing the mouse, the honeybees had to use propolis to prevent the decomposition

of the carcass and the generation of various harmful substances from the carcass as they could not take out

such a big carcass from the beehive.

As shown in the story, propolis is a great gift to mankind by diligent and wise honeybees.

Class SubstanceResin 40%–60%

PhenolicsPhenols, phenolic acids, esters, flavanones, dihydroflavanons, flavones, flavonols, chalkones, and phenolic glycerides

Wax: 20%–30% Beeswax substancesEssential oils (Maximum: 10%)

VolatilesMono- and sesquiterpenes

Others: 5% Minerals, carbohydratesCa, Zn, Fe, Mn, Se, Si, Cu, and others

(Poplar propolis is best studied; several hundred substances are identified.)

(Bogdanov and Gallman, 2007)

Composition of Propolis

1. Physical role

○ Propolis fills in the cracks of beehives, making them strong by supporting their weak areas.

2. Physiochemical role

○ Beehives are easily contaminated as bees enter and leave them thousands of times a day. However, applying propolis to the beehives can prevent bacterial infections and block germs coming from the outside.

○ Before a queen bee lays eggs, worker bees clean her room first, and apply propolis to the room thinly and firmly to allow her to lay eggs in a completely sterilized environment.

○ Propolis protects foods stored in beehivesfrom being damaged while bee larvae grow.

Roles of Propolis

Propolis in Dongui Bogam (Principles and Practice of Eastern

Medicine) is called Nobongbang. It treats toothache in

Oehyeongpyeon (external medicine), and convulsion and epilepsy,

furuncles, breast boils, mastitis, breast cancer, and malignant

furuncles in Tangaekpyeon

(remedies).

Propolis in Dongui Bogam

1. Hippocrates (406–377 BC): Used propolis to treat pain and ulcer

2. Aristotle (384–322 BC): Used propolis for skin diseases and infectious diseases (Source:Animal Paper)

3. Planius (23–79 AD): “Propolis removes bad elements and irritation in the flesh, healsswollen edema, softens hardened tissues, and relieves pain including those that cannot beeasily cured.“ (Source: Natural History)

4. Abisenna, an Iranian philosopher in the 11th century: “Apply propolis on the spot afterpulling out a thorn or an arrow to prevent the skin from being infected and to relievepain.“

5. Propolis was used to treat pyrogenic infections during the Inca Empire of the Andeanregion of South America during the first half of the 12th century.

6. In France, during the 18th and 19th centuries, propolis was mixed with Vaseline to treatwounded soldiers during war.

7. Remmy Sauvin, a professor at the Department of Biochemistry of Paris-SorbonneUniversity, released a paper called “Clinical Effect of Propolis“ in 1966. The paper states:“There are about 20,000 honeybees in a beehive that is the size of an apple box. Theinside temperature of that beehive is about 32℃, and its humidity is very high. Thus, it is avery good condition for bacterial growth. However, there were no bacteria in thebeehive.“ This shows the functionality of propolis as a natural antibiotic.

Propolis in History

16

Antibacterial Effects of PropolisExtract

Grange and Davey (1990): The propolis extract (at a concentration of 3 mg/mL)selectively inhibits cocci and gram-positive bacillus; strongly suppresses the growth ofStaphylococcus aureus, Staphylococcus epidermidis, Enterococcus species,Corynebacterium species, Branhamella catarrhalis, and Bacillus cereus; and partiallyinhibits the growth of Pseudomonas aeruginosa and Escherichia coli. They found thatthese effects were caused by the galangin and caffeic acid phenetyl ester in thepropolis extract.

The antibacterial effect against Bacillus subtilis, Staphylococcus aureus, Candidaalbicans, and Tricophyton mentagrophytes among 25 substances of the flavonoid ofpropolis is caused by galangine, pinocembrin, pinobanksin, 3-acetyl pinobanksin,cinnamic acid, p-coumaric acid benzyl ester, caffeic acid, and the caffeic acid estercompounds of flavonoid.

Comparing five kinds of antibiotics showed that propolis is not stronger thanantibiotics but comprehensively affects all kinds of bacteria. In addition, propolis has astrong effect on Tricophyton mentagrophytes.

In particular, propolis is strongly effective against Staphylococcus epidermidis, whichcauses acne; Malassezia furfur, which causes dandruff; and Trichomonas vaginalis ,which causes vaginitis, compared with other antibiotics.

The important characteristics of propolis do not generate resistant bacteria nor affectBifidobacterium, which is a beneficial intestinal bacteria, and lactic acid bacteria.

Propolis Research Trends

A total of 3,454 documents, 2,506 papers, 911 patents, and 37 reports

ホルモン様活性抗不整脈作用抗高血圧作用

抗ウイルス（HIV)作用抗細胞死作用免疫賦活作用腎臓保護作用抗放射線作用抗電磁波作用神経保護作用

抗炎症作用抗酸化作用抗腫瘍作用

抗微生物活性

0 5 10 15 20 論文数（2005年）

18

Mechanisms of Propolis in the Human Body (1)

1. Inhibits the decomposition of adenosine triphosphate (ATP) in cells to

revitalize the human body

○ The flavonoid compound in propolis inhibits the reaction of ATPase, which

decomposes ATP in cells to stimulate ATP and revitalize the human body.

○ ATP has three phosphoric acids that combine with adenosine. The two (p)

atoms at the ends have a high-energy phosphate bond, which makes them

generate high energy when they are decomposed. When the human body

needs energy, it uses the energy generated when ATP is decomposed by an

enzyme and converted into adenosine diphosphate (ADP). Thus, the

flavonoid prevents the unnecessary decomposition of ATP in cells, and

efficiently controls ATP to strengthen the vital power of cells and activate

the mechanism of the human body.

19

2. Suppresses the absorption of lipoperoxide and prevents aging

○ When the flavonoid of propolis is absorbed into the human body, it binds

itself to the receptors outside of cell walls to activate cell membranes. The

activated cell membranes regulate phagocytosis to selectively absorb ions

(e.g., Ca++) and nutrients. When lipoperoxide is increased in the human body,

an excessive amount of harmful oxygen is generated, and the excess oxygen

causes an oxidative destruction of unsaturated fatty acids on cell walls and

protoplasm in intracellular compartments. These lead to cell metabolism

disorder and aging. Flavonoid-bound cell membranes can selectively absorb

nutrients so that lipoperoxide absorption is blocked and aging is prevented.

Mechanisms of Propolis in the Human Body (2)

20

3. Activates the immune function

○ T and B cells, which play an important role in the immune system, are

broken by free radicals. Propolis catches and removes these free radicals.

○ When macrophages dig traps on cell surfaces and swallow enemies,

flavonoids smoothen cell surfaces and stimulate the formation of traps to

help in phagocytosis.

○ Propolis marks the outer walls of antigens to help T cells recognize

them as enemies.

○ Flavonoids stimulate leukocytes to produce a lot of interferons to fight

against antigens that intrude into cells.

Mechanisms of Propolis in the Human Body (3)

21

4. Inhibits allergic reaction

○ Flavonoids inhibit ATPase, which decomposes ATP, making it suppress the

binding between antigens and immunoglobulin E antibodies to control the

synthesis of adenosine monophosphate (AMP) and prevent histamine from

being separated from mast cells for the inhibition of allergic reaction. That is,

flavonoids activate calcium (Ca++) to prevent the histamine converted to (+)

from being separated, and neutralize the histamine.

Mechanisms of Propolis in the Human Body (4)

22

5. Inhibits pain

○ Prostaglandins (PGs) are synthesized in the cellular tissues of animals

and cause pain. The flavonoids of propolis control the creation of PGs to

inhibit pain.

○ When cell tissues encounter stress, arachidonic acids are secreted to

create PGs. The PGs cause various types of pain and generate free radicals

to break cells. Flavonoids inhibit the creation of PGs in arachidonic acids

when there are excessive PGs. This process is identical with the reaction of

aspirin.

Mechanisms of Propolis in the Human Body (5)

23

6. Strengthens the connective tissues of the skin and maintains skin

elasticity

○ The flavonoids of propolis inhibit the hydrolase reaction that

decomposes mucopolysaccharides (connective tissues) and prevent the

disorder of collagen fibers or the damage of skin tissues.

○ Collagen contains much hydroxyplorin. That is, the synthesis of the

hydroxyl groups (OH) of amino acid and fluorine is accelerated by

flavonoids. Thus, flavonoids prevent the damage of skin tissues, stimulate

collagen synthesis, maintain skin elasticity, and regenerate blood vessel

walls.

Mechanisms of Propolis in the Human Body (6)

1) Production Standard(1) Raw Material: Propolis is made by honeybees by combining their secretions with the resin they collect from plants.(2) Production Method: Wax is removed from the raw material, and propolis is extracted from the material by using water, alcohol, a mixture of water and alcohol, or carbon dioxide (supercritical carbon dioxide extraction).(3) Content of Functional Substances: The total flavonoids should be 10 mg/g or higher, and there should be (ρ)-coumaric acid and cinnamic acids.(4) Caution during Production: Diethylene glycol should not be used.

2) Standards(1) Property: Has a unique color and flavor, does

not have an off-taste and odor(2) Total Flavonoids(A) Raw Material: Nominal quantity or higher(B) Final Product: 80%–120% of the nominal

quantity(3) Para (ρ)-Coumaric Acid: Detected(4) Cinnamic Acid: Detected(5) Lead (mg/kg): Below 5.0 mg/kg(6) Diethylene Glycol: Not detected(7) Tetracycline (mg/kg): Not detected(8) Chloretetracyclines (mg/kg): Not detected(9) Coliform Group: Negative

Standards of Propolis Extract: Notification(1)

3) Final Product’s Requirements(1) Efficacy: Can improve oral hygiene by killing germs and has antioxidant

capabilities※ In terms of the antibacterial activity in the oral cavity, it is limited to the type that

directly comes into contact with the oral cavity (e.g., spray, tincture, or soft capsule), and the intake quantity is not applied.(2) Daily ValueTotal Flavonoids: 16–17 mg(3) CautionsDo not use this product if you are allergic to propolis.

4) Test Method(1) Total Flavonoids: Ⅲ.3.6.3(2) Para (ρ)-Coumaric Acid and Cinnamic Acids:

Ⅲ.3.6.4(3) Lead: See [Asterisk 4].(4) Diethylene Glycol: Ⅲ.2.5.3 (5) Tetracycline, Chloretracetracycline: See [Asterisk 4].(6) Coliform Group: See [Asterisk 4].

Standards of Propolis Extract: Notification(2)

3. Product Introduction

Manufactured Items ReportNo. Name TF (%) Characteristics/Use

2015001201301 Unique Water-Soluble Propolis 1.86 Water-soluble/product

2015001201302 Unique Water-Soluble Propolis 2.00 Raw material

2015001201303 Unique Water-Soluble Propolis Extract 120 1.20 Water-soluble / raw material

2015001201304 Unique Water-Soluble Propolis Extract 400 4.00 Water-soluble / raw material

2015001201305 Unique Water-Soluble Propolis Spray 0.20 Water-soluble spray product

2015001201306 Unique Water-Soluble Propolis Extract 300 3.00 Water-soluble / raw material

2015001201307 Unique Water-Soluble Propolis Extract 150 1.50 Water-soluble / raw material

2015001201308 Unique Water-Soluble Propolis Extract 200 2.00 Water-soluble / raw material

2015001201309 Unique Water-Soluble Propolis 120 1.20 Water-soluble/product

2015001201310 Unique Water-Soluble Propolis 110 1.00 Raw material

2015001201311 Unique Water-Soluble Propolis Extract 110 1.00 Water-soluble / raw material

2015001201312 Unique Water-Soluble Propolis 150 1.50 Raw material

2015001201313 Unique Water-Soluble Propolis S 1.00 Water-soluble / spray raw material

2015001201314 Unique Water-Soluble Propolis T 2.00 Water-soluble / toothpaste raw material

2015001201315 Water-Soluble GD-Polis Propolis 1.66 Water-soluble/product

2015001201316 Unique Water-Soluble Honey Propolis 1.00 Water-soluble/product

2015001201317 Unique Water-Soluble Honey Propolis Extract 1.00 Water-soluble / raw material

2015001201318 Unique Water-Soluble Propolis Extract (S-H) 1.00 Water-soluble / spray raw material

2015001201319 Unique Water-Soluble Honey Propolis Spray 0.50 Water-soluble spray / product

2015001201320 Solubpolis 1.00 For export / raw material

2015001201321 Water-Soluble Propolis 1.20 Water-soluble/product

2015001201322 Unique Water-soluble Propolis Extracts 1.00 Water-soluble / raw material

2015001201323 Unique Water-soluble Honey Propolis Spray 0.50 Water-soluble/spray raw material

2015001201324 Unibee Propolis Spray 0.50 Water-soluble / product

2015001201325 Unibee Propolis 0.70 Water-soluble/ product

2015001201326 BS Propolis 0.70 Water-soluble/ product

2015001201327 BS Propolis spray 0.50 Water-soluble/ product

Unibee Propolis

Type: Health functional food / dropperName: Unibee PropolisWeight: 30 mLTF: 0.7% or higherPackaging Materials: Glass container, dropper,

and paper box Efficacy: Can improve oral hygiene by killing

germs and has antioxidant capabilitiesUsage: Take 0.77mL (17 drops) three times a

day with water, milk, yogurt, tea, or other drinks.

Technical Characteristics: Produced with the patented technology, “The Manufacturing Method of Eco-Friendly, Alcohol-Free, and Water-Soluble Propolis Using Natural Honey” (No. 10-1661495). It is a pure water-soluble propolis product with no emulsifiers and chemical additives.

Unibee Propolis Spray

Type: Health functional food / sprayName: Unibee Propolis Spray

Weight: 20 mLTF: 0.50% Packaging Materials: PET container, spray, and paper box

Efficacy: Can improve oral hygiene by killing germs and has antioxidant capabilities

Technical Characteristics: Using the raw materials produced with the patented technology No. 10-1661495, this product is made with the patented technology, “The Manufacturing Method of High-Content and Water-Soluble Propolis Spray” (No. 10-1765455).Usage: Take 1.10 g (about six injections) three times a day by directly spraying the product into your mouth.

Unique Water-Soluble Honey Propolis

Type: Health functional food / dropperName: Unique Water-Soluble HoneyPropolisWeight: 30 mLTF: 1.00% or higherPackaging Materials: Glass container, dropper,

and paper box Efficacy: Can improve oral hygiene by killing

germs and has antioxidant capabilitiesUsage: Take 0.55 mL (12 drops) three times a

day with water, milk, yogurt, tea, or other drinks.Technical Characteristics: Produced with the patented technology, “The Manufacturing Method of Eco-Friendly, Alcohol-Free, and Water-Soluble Propolis Using Natural Honey” (No. 10-1661495). It is a pure water-soluble propolis product with no emulsifiers and chemical additives.

Unique Water-Soluble HoneyPropolis Spray

Type: Health functional food / sprayName: Unique Water-Soluble Honey Propolis SprayWeight: 20 mLTF: 0.50% Packaging Materials: PET container, spray, and paper boxEfficacy: Can improve oral hygiene by killing germs and has antioxidant capabilities

Technical Characteristics: Using the raw materials produced with the patented technology No. 10-1661495, this product is made with the patented technology, “The Manufacturing Method of High-Content and Water-Soluble Propolis Spray” (No. 10-1765455).Usage: Take 1.10 g (about six injections) three times a day by directly spraying the product into your mouth.

Unique Water-Soluble Propolis

Type: Health functional food / dropper

Name: Unique Water-Soluble Propolis

Technical Characteristics: Produced with thepatented technology, “The ManufacturingMethod of Eco-Friendly, Alcohol-Free, andWater-Soluble Propolis” (No. 10-1403511)Weight: 30 mLTF: 1.86%Packaging Materials: Glass container, dropper,and paper boxEfficacy: Can improve oral hygiene by killinggerms and has antioxidant capabilitiesUsage: Take 0.30 mL (10 drops) three times aday with water, milk, yogurt, tea, or otherdrinks.

Unique Water-Soluble Propolis 120

Type: Health functional food / dropper

Name: Unique Water-Soluble Propolis 120

Technical Characteristics: Produced with thepatented technology, “The ManufacturingMethod of Eco-Friendly, Alcohol-Free, andWater-Soluble Propolis” (No. 10-1403511).Weight: 30 mLTF: 1.20%Packaging Materials: Glass container, dropper,and paper boxEfficacy: Can improve oral hygiene by killinggerms and has antioxidant capabilitiesUsage: Take 0.45 mL (12 drops) three times aday with water, milk, yogurt, tea, or otherdrinks.

Unique Water-Soluble Propolis Spray

Type: Health functional food / sprayName: Unique Water-Soluble Propolis SprayWeight: 20 mL TF: 0.20% Technical Characteristics: Produced with the patented technology, “The Manufacturing Method of High-Content and Water-Soluble Propolis Spray” (No. 10-1765455).Packaging Materials: PET container, spray, and paper box Efficacy: Can improve oral hygiene by killing germs and has antioxidant capabilitiesUsage: Take 1.60 g (about eight injections) five times a day by directly spraying the product into your mouth.

Unique Propolis Toothpaste

Type: Quasi-drug/toothpaste Name: Unique Propolis ToothpasteWeight: 120 g × 4/set = (480 g/set)Packaging Materials: PP and box Technical Characteristics: Produced with the patented technology, “The Manufacturing Method of Eco-Friendly, Alcohol-Free, and Water-Soluble Propolis” (No. 10-1403511).Usage: Brush your teeth with an appropriate amount.Efficacy: Removes dental plaque and makes teeth white and strong; keeps mouth clean and fresh, and prevents cavities, bad breath, gingivitis, periodontitis, and gum and periodontal diseases

Product Characteristics(1)

A water-soluble substance highly absorbable by the human body

- Its absorption into the mucous membrane (percutaneous) of the oral cavity or a digestive organ shows a rapid effect.

- Liquid > Capsule, Tablet

Efficacy- Can improve oral hygiene by killing germs and has antioxidant

capabilities

Safety- Its low-temperature production process does not break

physiologically active substances.- The stability of flavonoids are secured during distribution.

The products are developed through a technical transfer from the Rural Development Administration (RDA), a government agency.

We received a technical transfer of the “Method for Manufacturing Water-Soluble

Propolis Composition and Water-Soluble Propolis Composition (No. 10-1677049),”

a patented technology developed by the RDA, and combined this with our

technology, “The Manufacturing Method of Eco-Friendly, Alcohol-Free, and Water-

Soluble Propolis.” As a result, we developed a technology, “The Manufacturing

Method of Eco-Friendly, Alcohol-Free, and Water-Soluble Propolis Using Natural

Honey,” and a product, the “Unique Water-Soluble Honey Propolis.”

Product Characteristics(2)

This product is alcohol-free and water-soluble, which enables it to completelydissolve in water.Depending on your preference, you can dilute this product with water, tea, milk,yogurt, or other drinks.

[Existing Foreign Products] [Our Product]

Product Characteristics(3)

“The Manufacturing Method of Eco-Friendly, Alcohol-Free, and Water-Soluble Propolis

Using Natural Honey”

It is the first of its kind in the world as it is produced with a patented technology.

Our product is manufactured with a patented technology unique in the world.

Patent in Korea(No. 10-1661495)

International Patent(PCT/KR2016/007859)

Product Characteristics(4)

Certified as a New Excellent Technology (NET) by the MAFRA

This technology was certified as a “New Excellent

Technology (No. 32-029)“ in accordance to Article 12-2

of the Act on the Promotion of Science and Technology

for Food, Agriculture, Forestry and Fisheries on July 1,

2016, through the review and evaluation of the “2016

Certification of New Excellent Technology” of the

MAFRA.

The NET certification, which is different from a patent,

is given to a new technology through a thorough

examination by the government of the technical

differentiation, efficacy, and effectiveness of a

technology.

Product Characteristics(5)

Typically, 50%–70% of alcohol is left in the propolis after it is extracted from alcohol. If

propolis is diluted with water, wax and resin are created. It is difficult to ingest propolis

due to its taste and flavor, which is caused by the alcohol left on it. To resolve this problem,

some countries produce propolis by using an emulsifier or chemical additives instead of

alcohol. This kind of propolis is not a genuine water-soluble product. It is not good for

people whose digestive organs are weak such as children or elderly people. However, our

“ Unique Water-Soluble Honey Propolis” does not contain alcohol and any harmful

additives such as emulsifiers and chemical additives. In addition, it is a pure water-soluble

product with a mild taste and flavor, which makes it safe for people of different genders

and of all ages including patients.

It contains no alcohol, emulsifiers, chemical additives, and wax.

It is a pure water-soluble propolis product without any harmful substances.

Product Characteristics(6)

The 1st Generation Propolis Extraction Technology

Propolis is extracted from alcohol, and 50%–70% alcohol is left. If the propolis is diluted with

water, its color becomes muddy, and wax and resin residues are created. Thus, it is better to

ingest the propolis with a very strong taste and flavor.

The 2nd Generation Propolis Extraction Technology

Propolis is produced by using emulsifiers and chemical additives, which makes it possibly harmful

to children and elderly people with a weak digestive system, as well as patients. (Emulsifiers:

Sucrose fatty acid ester, propylene glycol fatty acid ester, polyglycerine fatty acid ester,

polysorbate, and others)

The 3rd Generation Propolis Extraction Technology

Our product does not contain alcohol and any harmful additives such as emulsifiers and

chemical additives. As a pure water-soluble product, its color is light brown and is transparent,

with a mild taste and flavor. Thus, our product is safe for people of different genders and of all

ages including patients.

Manufactured using our 3rd Generation New Extraction Technology

Product Characteristics(7)

Industrial materials that can be used as various materials.

○ Taking “Unique Water-Soluble Honey Propolis” at the recommended

dosage every day is similar to taking 16–17 mg of flavonoid, which is a key

antibacterial and antioxidant substance.

○ The raw material HUWP-X110 is water-soluble at a pH of 9.0 ± 0.2 by

making a natural substance that is low molecular in an advanced way to

remove polysaccharides.

○ The raw material HUWP-X110 may cause precipitation by sensitively

responding to a polysaccharide or a change of pH.

Product Characteristics(8)

This product is developed and led by the best propolis experts.

2007–2012: Chairman of the MFDS’ health functional food code improvement committee2008–2009: Member of the KFDA’s regulatory reform committee2009–2012: Chairman of the KHSA’s distribution advancement committee 2008–2012: Member of the KHSA’s policy committee2007–2009: Member of the KFDA’s health functional food development council and system code improvement committeePresent: CEO of Unique Biotech Co., Ltd.

Director of Korea Beekeeping Association (KBA)Secretary-general of the WPSFVice president of the Korea Propolis Research Association

※ Conducted about 20 R&D propolis projects that were supported by the government※ Presented 19 academic researches of propolis in Korea and foreign countries

MBC News Desk [October 29, 2006]

MBC News and Focus[November 2, 2006]

KBS1TV Environment Special[November 22, 2006]

Product Characteristics(9)

Unique Biotech uses propolis from Australia, one of the cleanest countries in the world.The quality of a propolis product depends first and foremost on the natural environment where honeybees collect it and the type of trees surrounding the area.

Product Characteristics(10)

Good propolis contains a high level of flavonoids with antibacterial activitiesand antioxidative effects, and an even distribution of about 300 types ofphysiologically active substances.According to professor Vancova, a Bulgarian world-renowned propolisexpert, “Brazilian propolis has a low level of flavonoid and a high level ofArtepillin-C. It does not contain diverse substances evenly.“Artepillin-C (3,5-diprenyl-4-hydroxycinnamic acid) was named by Dr. TetsuyaMatsuno of Japan. It is a kind of cinnamic acid with a spicy flavor. Allpropolis contain cinnamic acid.However, Baccharis, which is grown in Brazil, contains this spicy substanceand is green in color. Thus, there is a misconception that this green propolisis good. The green propolis from Baccharis has a low content of flavonoidand a high content of cinnamic acid, which exists in all propolis. However, itdoes not have enough biologically active substances that need to be evenlycontained.

Australian propolis has a high content of flavonoids and an even distribution of diverse physiologically active materials.

Product Characteristics(11)

-1

-0.5

0

0.5

1

1.5

2

-1 -0.5 0 0.5 1

Flavonoid Type ＝ Populus Type

Non-Flavonoid Type

Okinawa Type

Baccharis Type

＝ Brazilian Type

Miscellaneous Type

PC1

Russia, Japan, Korea, China, the United States, New Zealand, Australia, Hungary, Bulgaria, Argentina, and

Uruguay

Jeju, Vietnam, Thailand, Congo, South Africa, Mexico, Cuba,

and Japan

PC２

Propolis has two types: flavonoid type and non-flavonoid type.Brazilian propolis is a non-flavonoid type, which means that its flavonoidcontent is low.

Understanding the Raw Materials of Propolis

(Bogdanov and Gallman, 2007)

Graph5

0.3543490.5577630.186657-0.298109-0.6084250.35892-0.276824-0.288897-0.287826-0.2075140.0881850.43584-0.0125110.163479-0.2878260.1126180.370487-0.027821-0.300304

0.316602-0.1022780.205117-0.292455-0.534489-0.2878260.2179870.146077

0.197387-0.04686-0.125681-0.301836-0.6622820.3083890.245488

-0.0324020.271867-0.288244-0.2814060.262299-0.273612

0.0679060.056672-0.237132-0.264892

0.315272-0.2028680.1633960.040377

0.6539150.324151-0.288211-0.288031

0.291808-0.1913550.25644-0.287826

0.353792-0.166044-0.259331-0.184854

0.066246-0.1448360.4807960.5451

0.259152-0.157251-0.15527

0.15745-0.033006-0.319826

0.0856840.134105-0.284399

0.5150840.077580.14098

0.2807460.2626760.484643

0.5222230.0642440.24523

-0.122077-0.243781

0.633787-0.274821

0.227482-0.212989

0.49364-0.035555

0.295629

0.337482

0.129937

-0.125559

-0.288401

-0.279059

-0.798244

-0.28747

-0.904492

-0.314192

-0.183134

-0.076758

-0.122317

-0.065542

-0.000983

-0.137196

NZ

China

Korea

Japan

Brazil

Chile

Mexico

Cuba

Congo

South Africa

Brugaria

Australia

USA

Hungary

Thailand

Argentine

Urguay

Russia

Vietnam

0.061044

0.111942

0.019561

-0.094996

-0.558011

0.059526

-0.086791

-0.089844

-0.089319

-0.071014

-0.003584

0.077542

-0.02441

0.01455

-0.089319

0.003144

0.062492

-0.030143

-0.095647

0.051936

-0.046499

0.025165

-0.09196

-0.449917

-0.089319

0.027412

0.010463

0.024333

-0.032972

-0.053078

-0.097111

-0.636746

0.047797

0.033942

-0.029827

0.03988

-0.089526

-0.087848

0.037846

-0.08606

-0.006971

-0.010095

-0.077581

-0.084042

0.051728

-0.069691

0.014158

-0.015441

0.129803

0.051602

-0.089509

-0.089421

0.046019

-0.067199

0.037184

-0.089319

0.060487

-0.06113

-0.082726

-0.065644

-0.006509

-0.057127

0.088078

0.103787

0.037571

-0.059398

-0.060817

0.013996

-0.030098

-0.106695

-0.002982

0.008359

-0.091376

0.09852

-0.00406

0.009833

0.043841

0.039845

0.089931

0.100515

-0.007377

0.034525

-0.051075

-0.079704

0.126473

-0.087316

0.030124

-0.072403

0.093482

-0.032623

0.045853

0.054463

0.007197

-0.052599

-0.090261

-0.08778

1.418656

-0.089373

1.733887

-0.103386

-0.065331

-0.040551

-0.051004

-0.037893

-0.023167

-0.05487

コメント

3か所０抜けがありました．０でいいですね？ ショヌ

UK23は全データが０で分散がないので分析からはずしました（確認を） ゼンブンサンブンセキカクニン

判別分析はサンプルの分類がわからないので ハンベツブンセキブンルイ

負荷量の大きな含有成分（順不同） フカリョウオオガンユウセイブンジュンフドウ

第１主成分 ダイシュセイブンUK1UK2pinobanksinnaringeninUK4pinocembrinUK7Uk8UK16UK17tectochrysin

第２主成分 ダイシュセイブンUK19UK28Uk31UK32UK45

第３主成分 ダイシュセイブンkaempherolartepillin C

第４主成分 ダイシュセイブンgalangin

第５主成分 ダイシュセイブン－－－

第６主成分 ダイシュセイブンUK9UK11Uk18UK20UK21UK25

データ

smpnsmpmk1mk2mk3mk4mk5mk6mk7mk8mk9mk10mk11mk12UK1UK2pinobanksinnaringeninUK3UK4UK5UK6pinocembrinUK7Uk8UK9Uk10chrysingalanginkaempherolUK11UK12UK13UK14UK15UK16UK17Uk18UK19UK20UK21UK22tectochrysinUK24UK25UK26artepillin CUK27UK28UK29UK30Uk31UK32UK34UK35UK36Uk37UK38UK39UK40UK41UK42Uk43UK44UK45UK46UK47UK48UK49UK50UK51UK52UK53UK54UK55

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固有値

第1主成分第2主成分第3主成分第4主成分第5主成分第6主成分第7主成分第8主成分第9主成分第10主成分第11主成分第12主成分第13主成分第14主成分第15主成分第16主成分第17主成分第18主成分第19主成分第20主成分第21主成分第22主成分第23主成分第24主成分第25主成分第26主成分第27主成分第28主成分第29主成分第30主成分第31主成分第32主成分第33主成分第34主成分第35主成分第36主成分第37主成分第38主成分第39主成分第40主成分第41主成分第42主成分第43主成分第44主成分第45主成分第46主成分第47主成分第48主成分第49主成分第50主成分第51主成分第52主成分第53主成分第54主成分第55主成分第56主成分第57主成分第58主成分第59主成分第60主成分第61主成分

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X(27)：UK21-0.019728-0.010249-0.0241680.019752-0.0147520.3245910.0630950.0350490.0007830.0125340.0220980.0028350.010203-0.00098-0.038206-0.0012870.004473-0.00374-0.0067250.003310.001993-0.000133-0.0006270.8531680.002008-0.0221160.002861-0.0617510.000550.000690.001350.000484-0.3881490.000013-0.000659-0.042215-0.027796-0.000066-0.0007-0.000288-0.00043-0.00037-0.000361-0.000339-0.000448-0.00032-0.0004330.0000090.0000090-0.0000140.000372-0.000007-0.0000080.0000280.000007-0.000012-0.000002-0.00000100

X(28)：UK22-0.0249920.0720250.020573-0.000662-0.0001160.0014720.0014810.0010610.0000290.0004380.0012640.0001370.000184-0.5265250.0003570.0008660.0003180.000642-0.0013640.000270.000112-0.000129-0.000424-0.0003530.000113-0.0005970.000249-0.000220.0000350.0000410.0002960.0000310.0000770.000594-0.000067-0.000124-0.000105-0.000005-0.000013-0.000013-0.000007-0.000007-0.000006-0.000006-0.000003-0.000006-0.00000200.78402800.000004-0.311924-0.000001-0.0000010.0640310.020689-0.0000010000

X(29)：tectochrysin0.1361630.031250.045436-0.212298-0.1914210.0065040.0658310.018299-0.0114490.1307110.090347-0.033219-0.185717-0.000184-0.0034470.6976040.000876-0.1367920.5490830.0013190.0026240.0533570.1355520.0003850.000063-0.035918-0.036543-0.0000380.0002050.0024930.0067490.000180.000172-0.0000790.0156610.000014-0.0000280.000225-0.000581-0.000367-0.0003530.000072-0.000297-0.000278-0.000081-0.000263-0.0000090.000003-0.0000230.0000020.000004-0.00000100.0000010.0000010.000007-0.0000090000

X(30)：UK24-0.001321-0.000662-0.001490.0005420.000013-0.002643-0.002258-0.002427-0.0000650-0.0068590-0.0062980.00000800.0000020-0.0000140.000007-0.000001-0.000108-0.0000770.000006-0.0000110.6103650-0.0000140-0.000008-0.000014-0.000006-0.0000070.0000030.0000010.000009000-0.000002-0.0000080.000027-0.0000010.0000230.0000220.0000060.000020.0000040.7920510.000001000.000001000000000

X(31)：UK25-0.007111-0.003679-0.0086770.006935-0.0053620.117220.0233820.0128080.0002430.0046180.0080160.0010290.003611-0.000281-0.002147-0.0002490.001831-0.001318-0.0026910.0015360.000721-0.000087-0.000301-0.003010.000722-0.0082680.001026-0.0000150.0001990.0002480.0004460.000175-0.007770.000005-0.0002590.992455-0.010321-0.000023-0.000252-0.000103-0.000156-0.000134-0.000131-0.000123-0.000162-0.000116-0.0001560.0000030.0000030-0.0000450.000005-0.000027-0.000030.0000010-0.000043-0.000001000

X(32)：UK26-0.002688-0.001457-0.0032760.001425-0.003224-0.007098-0.002842-0.006640.012576-0.0073960.0276170.0283940.0324680.000020.00258-0.0002350.002433-0.0001390.0686150.0014470.000171-0.060349-0.000430.0000360.000574-0.001250.604860-0.00002-0.0010850.000729-0.000017-0.0000180.000002-0.37324600-0.695336-0.000145-0.000218-0.000069-0.00015-0.000058-0.0000540.000011-0.0000510.00000900.000001-0.0000100.0000020000-0.0000190000

X(33)：artepillin C-0.237044-0.3465230.900958-0.0136-0.0003640.0326090.0206370.016401-0.0008490.0099580.0177010.0015730.009-0.0007920.005772-0.0042250.005348-0.001658-0.0017480.0045530.0019420.000364-0.0002820.0010070.001890.0018540.0022950.0000810.0006280.0006210.0007510.000551-0.000194-0.097165-0.0003980.0002130.000051-0.00008-0.000186-0.000155-0.000115-0.000115-0.000097-0.000091-0.000061-0.000086-0.0000430.0000060.0000730.0000010.0001470.0002050.0001070.0001190.0001340.000025-0.0000060000

X(34)：UK27-0.002618-0.001396-0.0031260.001267-0.002352-0.006687-0.002844-0.0063360.010523-0.0070170.0297460.0260950.0325020.0000190.002453-0.0002730.002304-0.0000240.0659190.0013780.000199-0.058386-0.0003640.0000340.0006010.0000410.585250-0.000019-0.0010370.000631-0.000016-0.0000170.000002-0.360989000.718679-0.000132-0.000198-0.000076-0.000142-0.000064-0.000060.000011-0.0000570.00000900.000001-0.00000800.0000020000-0.0000180000

X(35)：UK28-0.1161820.3455150.101937-0.003555-0.0000960.010430.005660.004514-0.0002410.0027740.0049760.000420.0025140.6503960.001605-0.0012160.001491-0.000428-0.0004890.0012730.0005530.000101-0.0000690.000290.0005290.0005540.0006570.0000240.000180.0001740.0002320.000158-0.000062-0.000127-0.0001190.0000580.000015-0.000023-0.000051-0.000039-0.000033-0.000031-0.000028-0.000026-0.000018-0.000025-0.0000140.0000020.54517800.0000180.34516-0.000006-0.000007-0.079594-0.103936-0.0000040000

X(36)：UK29-0.002594-0.001314-0.0030240.001580.000091-0.011929-0.0180890.132585-0.0000920.0057960.0081570.0006170.0032450.0000340.001915-0.0010420.001696-0.000464-0.0006890.0012850.0004550.00004-0.000392-0.0000230.0005190.0005080.0005320-0.0000290.000160.000202-0.000026-0.0000080.000002-0.0003600-0.000029-0.000183-0.000259-0.000134-0.000102-0.000112-0.0001050.000035-0.00010.00001700.000001000.00000200000.9908630000

X(37)：UK30-0.002777-0.001369-0.0030770.0011910.00026-0.005209-0.004674-0.0051-0.000065-0.006219-0.012972-0.001685-0.0117020.000016-0.0167140.000153-0.0322620.0000750.0001070.579406-0.000243-0.0001960.000042-0.000025-0.000344-0.000013-0.0001290-0.0000160.000337-0.000308-0.0000140.0000070.0000020.000064000.000045-0.096397-0.1299880.000053-0.0000020.0000440.0000420.0000110.0000390.00000700.0000010.79770700.0000020000-0.0000180000

X(38)：Uk31-0.0616760.1823420.053505-0.001875-0.0000510.0047920.0029790.002383-0.0001270.0014630.0026240.0002220.0013260.0545040.000846-0.0006410.000786-0.000227-0.0002570.0006710.0002880.000053-0.0000360.0001530.0002790.0002920.0003470.0000120.0000930.0000920.0001210.000082-0.000033-0.000067-0.0000630.0000310.000008-0.000012-0.000027-0.000022-0.000017-0.000017-0.000014-0.000013-0.000009-0.000013-0.0000060.000001-0.01249200.000009-0.008294-0.000003-0.000004-0.0020040.978177-0.0000020000

X(39)：UK32-0.2347460.6930830.203174-0.007126-0.0001930.0171350.0113150.009063-0.0004830.005560.0099750.0008420.00504-0.2323960.003217-0.0024360.002989-0.000865-0.0009790.0025520.001090.000202-0.0001380.0005810.001060.001110.0013180.0000470.0003530.0003480.0004580.00031-0.000125-0.000255-0.0002380.0001160.000029-0.000045-0.000102-0.000086-0.000063-0.000064-0.000053-0.00005-0.000033-0.000047-0.0000230.000004-0.25126800.000036-0.160807-0.000012-0.000013-0.507541-0.147982-0.0000070000

X(40)：UK34-0.009944-0.005056-0.0115080.0062950.00038-0.045872-0.0696670.508144-0.000370.0219880.0308820.0022450.0122990.0000160.007171-0.004170.006321-0.001819-0.002320.0047780.0017370.000204-0.001406-0.0001290.001980.0020460.001927-0.000232-0.0001120.0006210.000908-0.000098-0.0001280.000006-0.001363-0.000159-0.000116-0.000109-0.000681-0.000964-0.000511-0.000381-0.000429-0.0004030.000134-0.000380.000064-0.0000020.0000050-0.2562260.000207-0.15499-0.1725040.0000150.000004-0.0703640.0000010.00000100.779998

X(41)：UK350.000824-0.000207-0.000881-0.002733-0.00968-0.003393-0.003987-0.004120.075898-0.0066780.0406090.097436-0.0253880.0000080.002876-0.0041330.0016340.002309-0.0952640.0009140.0003550.9713560.0053620.0000450.0002860.002456-0.0051340-0.000007-0.0008460.001178-0.000006-0.0000520-0.171912000.000104-0.000321-0.000442-0.000113-0.000159-0.000095-0.0000890.000009-0.0000840.000005000000000-0.0000010000

X(42)：UK36-0.005509-0.002751-0.006530.0034960.0002-0.025427-0.0386680.282112-0.0002030.0122480.0171850.0012770.0068620.0000070.003993-0.0023050.003538-0.001038-0.0013110.0026570.0009650.000108-0.000784-0.0000670.00110.0011330.001068-0.00008-0.0000620.0003430.000435-0.000055-0.0000540.000003-0.000755-0.000057-0.000045-0.000061-0.000379-0.000536-0.000284-0.000213-0.000238-0.0002240.000074-0.0002110.000035-0.0000010.000003000.000117-0.086040.953260.0000090.000002-0.0390650.000001000

X(43)：Uk37-0.000906-0.000447-0.0010010.0003870-0.002433-0.001498-0.0016270-0.001944-0.0049170.00000100.0000010-0.00000100000.37519400-0.00000300000-0.0000030-0.00000600.0000010000-0.0000020-0.108138-0.000001-0.090711-0.085132-0.148388-0.080404-0.17173400000.00000100000000.8797970

X(44)：UK38-0.012394-0.006302-0.0143440.0078460.000474-0.057177-0.0868360.633369-0.0004610.0274060.0384920.0027980.015330.000020.008938-0.0051980.007878-0.002267-0.0028920.0059560.0021650.000255-0.001752-0.0001610.0024680.002550.002402-0.00029-0.000140.0007740.001132-0.000123-0.000160.000007-0.001699-0.000198-0.000144-0.000136-0.000849-0.001202-0.000638-0.000475-0.000535-0.0005020.000167-0.0004740.00008-0.0000020.0000060-0.3193690.000258-0.193185-0.2150160.0000190.000005-0.0877040.0000010.0000010-0.625782

X(45)：UK39-0.003673-0.001811-0.0040680.0015750.000344-0.00689-0.006183-0.006746-0.000087-0.008226-0.017161-0.002229-0.015480.000022-0.0221090.000203-0.0426770.0000970.0001420.766437-0.000322-0.0002580.000056-0.000033-0.000454-0.000018-0.0001870-0.0000210.000445-0.000393-0.0000190.0000090.0000020.000095000.000062-0.127514-0.1719480.00007-0.0000030.0000590.0000550.0000150.0000520.00000900.000002-0.60304500.000003000.0000010-0.0000240.000001000

X(46)：UK40-0.000952-0.00047-0.0010520.0004060-0.002552-0.001574-0.001710-0.002044-0.0051690.00000100.0000010-0.00000100000.39441700-0.0000030000-0.000001-0.0000030-0.00000600.0000010000-0.0000020-0.113679-0.000001-0.095358-0.089494-0.155991-0.084523-0.18053200000.000001000000.734818-0.370736-0.2699880

X(47)：UK41-0.007121-0.003628-0.0084350.0045170.000259-0.032847-0.049950.364422-0.0002650.0158210.0221940.0016450.008860.0000090.005153-0.0029790.004537-0.001336-0.0016910.0034290.0012460.000136-0.001013-0.0000980.0014210.0014650.001365-0.000103-0.000080.0004440.000562-0.000071-0.0000960.000004-0.001-0.000074-0.00009-0.000079-0.000489-0.000692-0.000367-0.000273-0.000308-0.0002890.000096-0.0002730.000046-0.0000010.00000300.9123330.000151-0.111154-0.1237150.0000110.000003-0.0504630.000001000

X(48)：UK42-0.000581-0.000287-0.0006420.000250-0.00043-0.0000010.0000010-0.0012480000.0000010000000.2408390000000000-0.000001000000000.965895-0.000001-0.058228-0.0546460-0.051611000000.000001000000000

X(49)：Uk43-0.000726-0.000359-0.0008020.0003120-0.0005420-0.0013090-0.001558-0.003942000.0000010-0.00000100000.3007440000000000-0.00000100000000-0.08668-0.000001-0.072711-0.0682390.942296-0.064449000000.000001000000000

X(50)：UK44-0.005415-0.002705-0.006420.0034380.000197-0.025-0.0380190.277378-0.00020.0120420.0168960.0012560.0067470.0000070.003926-0.0022660.003478-0.001021-0.0012890.0026120.0009490.000106-0.000771-0.0000660.0010810.0011140.00105-0.000078-0.0000610.0003380.000428-0.000054-0.0000530.000003-0.000742-0.000056-0.000045-0.00006-0.000372-0.000527-0.000279-0.00021-0.000234-0.000220.000073-0.0002080.000035-0.0000010.000003000.0001150.958592-0.0000070.0000080.000002-0.038410.000001000

X(51)：UK45-0.1470160.4345910.127384-0.004465-0.0001210.0110860.0070920.005678-0.0003020.0034840.006250.0005280.003158-0.0033250.002016-0.0015270.001873-0.000541-0.0006130.0015990.0006840.000127-0.0000860.0003640.0006640.0006950.0008260.000030.0002220.0002180.0002880.000195-0.000078-0.00016-0.0001490.0000730.000018-0.000028-0.000064-0.000053-0.00004-0.00004-0.000034-0.000032-0.000021-0.00003-0.0000150.000003-0.15743700.000022-0.100757-0.000007-0.0000080.853448-0.098312-0.0000050000

X(52)：UK46-0.000916-0.000453-0.0010130.0003910-0.002459-0.001515-0.0016460-0.001967-0.0049740.00000100.0000010-0.00000100000.37956900-0.00000300000-0.0000030-0.00000600.0000010000-0.0000020-0.109399-0.000001-0.091769-0.086125-0.150118-0.081342-0.17373600000.0000010000000.837397-0.2598240

X(53)：UK47-0.005525-0.002707-0.0060920.0023990.000525-0.011199-0.009701-0.010786-0.000465-0.013874-0.038846-0.003471-0.0313560.000033-0.0708580.0004550.9925860.0000510.0009160.051301-0.000637-0.0004250.00014-0.00167-0.000919-0.000158-0.0006290-0.0000340.000884-0.00077-0.000030.0006280.0000030.0001310-0.0000710.0001420.0002080.0002250.000147-0.0632290.0001230.0001160.0000240.0001090.00001500.000003000.000004-0.000021-0.0000240.0000010-0.0000360000

X(54)：UK48-0.00035-0.000172-0.00038700.000001000-0.0000040-0.0004660.00086200-0.00431600.0630710-0.000010.003379-0.000005-0.0000010-0.000097-0.0000050-0.000017000-0.00000600.0000410-0.000002000.000002000.0000010.9979930.0000010.00000100.000001000000000000000

X(55)：UK49-0.000738-0.000365-0.0008160.0003150-0.000551-0.001221-0.0013310-0.001585-0.004008000.0000010-0.00000100000.30581900-0.00000300000-0.0000020-0.00000100000000-0.088142-0.000001-0.073938-0.06939-0.12095-0.0655370.93245700000.000001000000000

X(56)：UK50-0.001032-0.000509-0.001140.000440-0.002773-0.001723-0.0018530-0.002214-0.00560.00000100.000001000-0.0000040-0.0000010.42730300-0.0000040000-0.000006-0.000003-0.000004-0.00000700.0000010000-0.000002-0.000006-0.123157-0.000001-0.10331-0.096956-0.168997-0.091571-0.19558500000.00000100000-0.678264-0.401648-0.2924990

X(57)：UK51-0.00051-0.000252-0.0005650.0002190-0.000378-0.0000010.0000010-0.00109700000000000.2117780000000000-0.000001000000000000.9762620-0.045384000000000000000

X(58)：UK52-0.000952-0.000474-0.0010630.0000010-0.00184600.0000060-0.0000010.0000010.00000100.0000010-0.0000010000-0.00001100000000.99999700-0.00000500.0000010000-0.00000200.000001-0.0000010.0000010.0000010.0000010.0000010.00000100000.00000100000-0.000003-0.000003-0.0000020

X(59)：UK53-0.000833-0.000415-0.0009320.0000010-0.00162300.0000050-0.0000010.000001000.0000010-0.0000010000-0.00000200000000000.999998000000-0.0000020-0.000001-0.000001-0.000001-0.000001-0.000001-0.000001-0.00000100000.000001000000000

X(60)：UK54-0.000505-0.000249-0.0005580.0002170-0.000374-0.0000010.0000010-0.00108600000000000.2095310000000000-0.00000100000000000000.977801000000000000000

X(61)：UK55-0.000517-0.000256-0.0005720.0002220-0.000383-0.0000010.0000010-0.0011120000.0000010000000.2146580000000000-0.00000100000000000.974388-0.0487060-0.046001000000000000000

固有値0.0965370.0606850.0448740.0113260.0079160.0066910.0051630.0038820.0028330.0020970.0015150.0014780.0010870.0006160.0005650.0003870.0003430.0003250.00020.0001250.0000670.0000650.0000540.0000350.0000330.0000310.0000290.000010.0000080.0000080.0000070.0000060.0000050.0000050.0000040.0000030.0000010.00000100000000000000000000000

寄与率0.3876760.2436990.1802050.0454820.0317890.0268690.0207320.015590.0113770.0084210.0060850.0059350.0043640.0024740.0022710.0015560.0013780.0013040.0008020.00050.0002670.000260.0002180.000140.0001310.0001250.0001170.0000390.0000330.0000310.0000270.0000230.0000220.0000210.0000140.0000130.0000060.0000040.0000010000000000000000000000

累積寄与率0.3876760.6313740.811580.8570620.8888510.915720.9364520.9520420.9634180.9718390.9779240.983860.9882230.9906970.9929680.9945240.9959020.9972060.9980080.9985080.9987750.9990350.9992530.9993930.9995240.9996490.9997660.9998050.9998370.9998680.9998960.9999190.999940.9999610.9999750.9999890.9999940.9999990.9999990.9999990.99999911111111111111111111

負荷量

第1主成分第2主成分第3主成分第4主成分第5主成分第6主成分第7主成分第8主成分第9主成分第10主成分第11主成分第12主成分第13主成分第14主成分第15主成分第16主成分第17主成分第18主成分第19主成分第20主成分第21主成分第22主成分第23主成分第24主成分第25主成分第26主成分第27主成分第28主成分第29主成分第30主成分第31主成分第32主成分第33主成分第34主成分第35主成分第36主成分第37主成分第38主成分第39主成分第40主成分第41主成分第42主成分第43主成分第44主成分第45主成分第46主成分第47主成分第48主成分第49主成分第50主成分第51主成分第52主成分第53主成分第54主成分第55主成分第56主成分第57主成分第58主成分第59主成分第60主成分第61主成分

X(1)：UK10.7403990.1329540.166136-0.0917030.1032610.051749-0.197887-0.027955-0.1750470.119751-0.10462-0.0665830.187465-0.000413-0.000425-0.34097-0.004869-0.2207660.165557-0.006884-0.0099090.0576660.232855-0.007883-0.017474-0.0219950.003119-0.002549-0.007202-0.01467-0.022212-0.0078410.0067080.011605-0.012988-0.000905-0.0025760.0100830.0540060.1944810.13849-0.0039960.1384890.1383060.0906910.138983-0.051551-0.0010930.306640.0041560.1325240.1314530.0597110.0650.1126890.7592590.143441-0.0916510.0645760.142221NAN

X(2)：UK20.6667970.1095270.1250760.2619590.054166-0.022879-0.115031-0.0446540.1299660.151641-0.156255-0.0126180.2491580.002091-0.01057-0.224636-0.0232-0.1961830.186805-0.034697-0.0314540.015069-0.035415-0.018867-0.0418630.116071-0.007548-0.003166-0.0261730.0001330.445393-0.0277480.0097660.0139070.012082-0.007759-0.0029250.0470460.0963420.1800730.1840940.0178270.1840840.1837030.0924230.1847310.023025-0.0096460.2609370.0045610.1101590.0599310.0542590.0575020.0641760.6736390.313746-0.102730.049290.032852NAN

X(3)：pinobanksin0.6718610.129440.1736210.1375630.0757680.051974-0.16208-0.0112890.1371790.089667-0.192880.023410.149422-0.0018320.004405-0.342837-0.004075-0.2708760.373053-0.001428-0.0058850.026019-0.1973490.001288-0.012089-0.052255-0.0550570.0010950.0058980.021314-0.0015520.0059310.0046560.0078370.0528350.0091550.0028660.0290530.0823520.1972170.1831620.0505940.182970.1827590.0664310.18337-0.0519260.0037650.2936610.0036290.1329270.1464460.056090.0625530.1258530.7003860.292695-0.0980850.0445160.039141NAN

X(4)：naringenin0.7629210.0945650.061485-0.144808-0.0632120.3243710.1793480.005796-0.1295830.1072850.0982080.0093610.108930.005020.167728-0.1329970.001910.0870040.16998-0.021366-0.0271130.0877080.028569-0.022527-0.038650.3327940.010724-0.039299-0.052055-0.002090.076972-0.0549060.0182820.0061990.057971-0.035867-0.030354-0.000581-0.220855-0.152806-0.276837-0.343709-0.277023-0.277232-0.361707-0.276001-0.324511-0.017664-0.1572230.0064170.0470220.3176520.0282590.021358-0.0867720.685854-0.273929-0.522116-0.232602-0.091014NAN

X(5)：UK30.006977-0.030558-0.079741-0.1691270.325785-0.1043370.171868-0.045573-0.222044-0.0341790.482410.2523820.42050.0057890.037061-0.08160.0281290.4922860.1945680.009998-0.015239-0.0098640.010256-0.0252430.011591-0.0466060.019878-0.009473-0.050761-0.022902-0.042539-0.053269-0.0078970.0143890.162278-0.03144-0.013933-0.062438-0.221283-0.461532-0.353587-0.519616-0.353331-0.353113-0.032848