True or false?

Blood is red because of the iron in hemoglobin.

“Red blood cells”A close-up of red bloodcells within a capillary.

Over 99 percentof the blood vessels in the

body are capillaries,even though they only hold 5 percent of the body’s blood.

False

por·phy·rinFunction: nounEtymology: from Greek porphyra purple

-any of various compounds with a macrocyclic structure that consists essentially of four pyrrole rings joined by four =CH- groups; especially : one (as chlorophyll or hemoglobin) containing a central metal atom and usually exhibiting biological activity

How to draw a porphyrin:

Protoporphyrin IX

Glycine +Succinyl CoA

the pyrrole ring is formed

HN

R

O

aldehyde

propionic acid

pyrrole

+

N

N

HNNHΔ

R

R

R

R

The Adler synthesis of simple, symmetrically substituted porphyrins:

Meso position

R = phenyl (TPP) toluyl (TTP) p-chlorophenyl (TClPP)

The Ru-DNA Binding Project

N

N

KBr,Conc. H2SO4Conc. HNO3

95 dec C, 2.5 h

N

N

O

O

1, 10-phenanthroline 1, 10-phenanthroline-5,6-dione

N

N N

N

NH

NH

O

O

N

N O

O

N

N N

N

N

N

O

O

CH3

CH3

N

N N

N

NH

N

O

NH2

N

N N

N

N

N

NH2

NH2

H2N

H2N

NH

NH

O

O

H2N

H2N

N

N

O

O

CH3

CH3

H2N

H2N

NH

N

O

NH2

H2N

H2N

N

N

NH2

NH2

NaOH, pH ~11

MeOH, 20 h

"phen-alloxazine"

(L-allox)

"phen-dimethylalloxazine"

(L-Me2allox)

"phen-pterin" (L-pterin)

"phen-diaminopteridine"

(L-diamino)

N

N N

N

N

N

NH2H2N

H2N

N

N

NH2"phen-aminopteridine"

(L-amino)

Ligand Synthesis: Condensations are a Theme

Schiff-Base Ligands

N

N

O

N

NN

N

O

H

H

H

H

H

R

N

N

C-pterin hydrogen bonding

N

N N

N

O

N

NN

N

O

H

H

H

H

H

R

R

C-G hydrogen bonding

Watson-Crick Base Pairing

N

NN

N

O

N

N N

N

O

H

H

H

H

H

R

R

N

N N

O

H

H

H

R

N

NN

N

O

N

N N

N

O

H

H

H

H

H

R

R

N

Ru N

N

N

N

N

N

N

N

N

O

N

HH

H

Triplex DNA Base Pairing

The Ru-DNA Binding Project