Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

by Mauro Di Ianni, Franca Falzetti, Alessandra Carotti, Adelmo Terenzi, Flora Castellino, Elisabetta Bonifacio, Beatrice Del Papa, Tiziana Zei, Roberta Iacucci

Ostini, Debora Cecchini, Teresa Aloisi, Katia Perruccio, Loredana Ruggeri, Chiara Balucani, Antonio Pierini, Paolo Sportoletti, Cynthia Aristei, Brunangelo Falini, Yair

Reisner, Andrea Velardi, Franco Aversa, and Massimo F. Martelli

BloodVolume 117(14):3921-3928

April 7, 2011

©2011 by American Society of Hematology

Overall view of the protocol.

Mauro Di Ianni et al. Blood 2011;117:3921-3928

©2011 by American Society of Hematology

Immunophenotype of the immunoselected Tregs.

Mauro Di Ianni et al. Blood 2011;117:3921-3928

©2011 by American Society of Hematology

Immunophenotype of the immunoselected Tregs.

Mauro Di Ianni et al. Blood 2011;117:3921-3928

©2011 by American Society of Hematology

Immunologic reconstitution after Treg-based transplantation.

Mauro Di Ianni et al. Blood 2011;117:3921-3928

©2011 by American Society of Hematology

Immunologic reconstitution after Treg-based transplantation.

Mauro Di Ianni et al. Blood 2011;117:3921-3928

©2011 by American Society of Hematology

Regeneration of alloreactive NK-cell repertoires against a KIR-ligand–mismatched target.

Mauro Di Ianni et al. Blood 2011;117:3921-3928

©2011 by American Society of Hematology