treating the cause to prevent and reverse heart diseaseprevent and reverse heart disease caldwell b....
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Treating the Cause to
Prevent and Reverse
Heart Disease
Caldwell B. Esselstyn Jr., M.D.
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Dr Esselstyn reports no known
financial conflicts.
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Absence of Coronary Artery
Disease
• Rural China
• Papua Highlanders
• Central Africa
• Tarahumara Indians
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Treating The Cause
Endothelial Cell
Endothelial Progenitor Cell
HDL Cholesterol
Dimethyl Arginine Dimethylamino
Hydrolase
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Participants 1985 - 1988
23 men, 1 woman with severe triple vessel coronary artery disease – age range 44 - 68
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Method
• Oil
• Fish
• Fowl
• Meat
• Dairy
• Caffeinated
Coffee
Avoid
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Lecithin and Carnitine
Eggs Poultry
Milk Pork
Cream Duck
Dairy Lamb
Liver Venison
Red Meat Shell Fish
Fish
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Lecithin Gut
Carnitine Bacteria TMAO Vascular Disease
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Foods to be Included
• Whole Grains
• Legumes, lentils
• Vegetables
• Fruit
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8 Years Prior to Study
49 Coronary Events in 18 Patients
Increased angina 18
Angiographic disease progression 13
Bypass surgery 7
Infarctions 4
Strokes 3
Angioplasty 2
Worsening stress test 2
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18 Patients Followed 12 Years
• 49 coronary events during 8 years
prior to study
• None in 17 compliant patients
during 12 years
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Treating the Cause
3.75 Years Follow-Up
Lost to Follow Up 2
Adherent (89%) 177
Non-Adherent 21
TOTAL 200
J Fam Prac Vol 63 July 2014
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‘SEVERITY INDEX’
Patients With Intervention (119)
Patients Avoiding Intervention (27)
Severity Index 146/177 = 82%
J Fam Prac Vol 63 July 2014
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Recurrent Events(%)
Adherent 0.6
Non-Adherent 62
J Fam Prac Vol 63 July 2014
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Treating The Cause
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Arrest and Reversal Outcomes
• No mortality from the diet
• No morbidity from the diet
• Benefits improve with time
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Quality of Life Issues
Patients are empowered by the
knowledge that they are in control of
the disease that was destroying their
lives
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Baseline Cholesterol 248 mg/dl
10-14 days 137 mg/dl
Left Right
Before Rx After Rx
Esselstyn 2007
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8 Measures of Cardiovascular Disease Reversal
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