transforming the ctri and ucsd: from silo to collaboration gary s. firestein, m.d
TRANSCRIPT
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Transforming the CTRI and UCSD:From Silo to Collaboration
Gary S. Firestein, M.D.
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Clinical and Translational Research Institute
• Organized Research Unit, est. 2010• Funded by institutional funds, CTSA, CTSA supplements,
UCOP, industry funding and NHLBI U54• ~$59 M extramural funding
• Informatics, clinical research and laboaratory infrastructure• Pilot project and Catalyst grants• KL2/TL1/CREST programs• co-funding of investigator initiated projects (30-60%)
• ~$50 M in grants requiring CTRI letter of support• 782 members
• 655 UCSD• SDSU, Sanford Burnham, Salk, LIAI, Venter, others
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2010 2011 2012 2013
Nurses/Coord Nurses/Coord Nurses/Coord Nurses/Coord
Clinical Cores--DEXA--Exercise
Clinical Cores--DEXA--Exercise
Clinical Cores--DEXA--Exercise--Skin biopsy
Clinical Cores--DEXA--Exercise--Skin biopsy--Cardiac phenotype
Biostatistics Biostatistics Biostatistics Biostatistics
IRB service IRB service IRB service
Clinic Space (ECOB)
Clinic Space (ECOB)
Phase I unit
Center for Clinical Research 2010-2013
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Clinical and Translational Research Institute
• Clinical services since 2011• 261 protocols in CCR (108 currently active)
• ~3000 visits/year• 93 infusions (56 in first half of 2013)• 220 skin biopsies • 45 IRB submission consultations
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New CTRI to break down silos• Phase I unit
• Collaboration with the Cancer Center• Standard of Care billing• Experimental Pharmacy• Overnight stays• Begin in ECOB, then move to ACTRI
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2010 2011 2012 2013
Biomarker Biomarker Biomarker Biomarker
Biorepository--Storage
Biorepository--Storage--Collection--Velos
Biorepository--Storage--Collection--Velos--Management
Affiliated Cores--Mass Spec
Affiliated Cores--Mass Spec--HT screening
Affiliated Cores--Mass Spec--HT Screening--Genomics
Launching Pad
Translational Research Technology 2010-2013
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2010 2011 2012 2013
CDWR CDWR CDWR CDWR
CRIQueT CRIQueT CRIQueT
REDCap REDCap REDCap
ReX ReX
Biocomp Center--Genomics
Biocomp Center--Genomics--Epigenomics--Systems Biology
Velos Enterprise Velos
Data Concierge
Biomedical Informatics 2010-2013
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Clinical and Translational Research Institute
• Informatics and Biomarker services since 2011• 485 protocols in Velos (252 active)• 62 Bioinformatics projects• 99 Biomarker projects• 19,027 biosamples processed or collected• 18,392 biomarker assays performed
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New CTRI to break down silos
• Genomics and bioinformatics• Consolidate individual efforts at various centers in
the Institute for Genomic Medicine• Re-engineer BIOGEM• Center for Bioinformatics Analysis• Integrated assistance with study design, data
analysis, systems biology, ‘omics data• Collaboration and service models
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CTRI Funding Education
• CTRI TL1 Program• 3 m or 1 yr training for medical and pharmacy students
• CTRI KL2 Program• Institutional K award $100 K/yr• 10 Scholars funded since 2010• ~80 participants
• CTRI CREST Program• Modular program that can lead to MAS• Co-funding by the CTRI to lower tuition• >100 participants
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Simplifying access: ctri.ucsd.edu
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2010 2011 2012 2013
Translational Translational Translational Translational
Clinical Clinical Clinical Clinical
Innovation Innovation Innovation Innovation
Catalyst--CTRI services
Catalyst --CTRI services
Catalyst --CTRI services--Biomarkers--Drug discovery
Personalized Medicine
Engineering in Medicine
Co-funding with other centers
Pilot project grant program 2010-2013
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Resources available at the CTRI: Catalyst grants
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New CTRI to break down silos
• Drug Discovery at Sanford-Burnham• High throughput screening• Catalyst grants
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Resources available at the CTRI: Pilot project grants
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CTRI Funding Innovation
Bringing engineers and clinicians together to apply technology to unmet medical needs
GEM Program:Galvanizing Engineering in Medicine
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Altman CTRI Building: Designed to break down silos