transdermal clonidine disappointing for smokers

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Transdermal clonidine disappointing for smokers THERAPY The largest placebo-controlled study conducted to date shows that transdermal clonidine reduces early withdrawal symptoms of smoking cessation but has little effect on tobacco craving. Statistically significant, but small, reductions in anxiety and irritability were documented during the first week of cessation in a 5 centre trial reported in Archives of Internal Medicine, but overall cessation rates were not affected. However, there were considerable variations in response at individual centres which suggests that clonidine may be beneficial in some situations or some patient groups. 25% of patients stopped treatment as a result of adverse reactions, the most common being skin rash. Prochazka AY. Pelly TL. "iell L. Silve" W. Sachs D. et al. Transdernlal clonidine reduced some withdrawal symptoms but did not increase smoking cessation. Archives of Internal "kdicine 152: 2065-206<). Oct 1992 ISSN 0156-270319211107-00151$1.00° Adislntemational Ltd 15 INPHARMA"7 Nov 1992

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Page 1: Transdermal clonidine disappointing for smokers

Transdermal clonidine disappointing for smokers

THERAPY

The largest placebo-controlled study conducted to date shows that transdermal clonidine reduces early withdrawal symptoms of smoking cessation but has little effect on tobacco craving.

Statistically significant, but small, reductions in anxiety and irritability were documented during the first week of cessation in a 5 centre trial reported in Archives of Internal Medicine, but overall cessation rates were not affected.

However, there were considerable variations in response at individual centres which suggests that clonidine may be beneficial in some situations or some patient groups.

25% of patients stopped treatment as a result of adverse reactions, the most common being skin rash. Prochazka AY. Pelly TL. "iell L. Silve" W. Sachs D. et al. Transdernlal clonidine reduced some withdrawal symptoms but did not increase smoking cessation. Archives of Internal "kdicine 152: 2065-206<). Oct 1992

ISSN 0156-270319211107-00151$1.00° Adislntemational Ltd

15

INPHARMA"7 Nov 1992