transderm overview saratoga aesthetics

TransdermTransderm®®

IontoIontoThe The OnlyOnly FDA FDA

ApprovedApproved Alternative to Alternative to

InjectionsInjections

Manufactured By Manufactured By Mattioli EngineeringMattioli Engineering

Developed its first microdermabrasion Developed its first microdermabrasion system in 1991.system in 1991.

Over 6,500 microdermabrasion units Over 6,500 microdermabrasion units installed world-wide.installed world-wide.

Opened the US microdermabrasion in Opened the US microdermabrasion in 1996 when it introduced its FDA Cleared 1996 when it introduced its FDA Cleared Ultrapeel Crystal®Ultrapeel Crystal® and and Ultrapeel Pepita®Ultrapeel Pepita® microdermabrasion systems.microdermabrasion systems.

Introduced the FDA Cleared Introduced the FDA Cleared Transderm® Transderm® IontoIonto to the US market in 2003. to the US market in 2003.

FDAFDA ClearanceClearance

The Transderm® Ionto is a The Transderm® Ionto is a powered drug delivery system powered drug delivery system that is indicated for the local that is indicated for the local administration of administration of ionic drug ionic drug solutionssolutions into the body for into the body for

medical purposes and can be medical purposes and can be used as used as an alternative to an alternative to

injectionsinjections. .

The TransdermThe Transderm®® IS NOTIS NOT……

An Ultrasound DeviceAn Ultrasound Device A Muscle StimulatorA Muscle Stimulator A MassagerA Massager A Micro-Current DeviceA Micro-Current Device

……..It is a MEDICAL system for ..It is a MEDICAL system for your MEDICAL practice!your MEDICAL practice!

Limits of Pre-Existing Limits of Pre-Existing TechnologyTechnology

Traditional IonthophoresisTraditional Ionthophoresis Ineffective for heavy weight moleculesIneffective for heavy weight molecules Changes the pH of ionic drug solutionsChanges the pH of ionic drug solutions Electrolytic effect at the electrodesElectrolytic effect at the electrodes Electrolysis of the ionic solutionElectrolysis of the ionic solution

MicrodermabrasionMicrodermabrasion Low delivery rateLow delivery rate Effects limited to the skin surfaceEffects limited to the skin surface

ElectroporationElectroporation High peak currents High peak currents High risk of skin damageHigh risk of skin damage Adverse effectsAdverse effects

The TransdermThe Transderm®® Uses Uses DermoelectroporationDermoelectroporation®®

DermoelectroporationDermoelectroporation®® uses continuous uses continuous reversed polarity current pulses to deliver reversed polarity current pulses to deliver low-weight and heavy-weight molecules low-weight and heavy-weight molecules

without compromising the integrity of the without compromising the integrity of the solution.solution.

Just Two Easy StepsJust Two Easy Steps

Step One: Microdermabrasion

to Ensure Penetration and Reproducibility

Step Two: Dermoelectroporati

on®® for Transdermal Drug

Delivery

Advantages of Transdermal Advantages of Transdermal DeliveryDelivery

of Low-Weight Moleculesof Low-Weight Molecules Positive and negative ions of the drug are Positive and negative ions of the drug are

transdermally delivered at the same timetransdermally delivered at the same time No electrolytic reactions at the electrodesNo electrolytic reactions at the electrodes No change of ionic drug solution pHNo change of ionic drug solution pH No electrolysis of ionic drug solution No electrolysis of ionic drug solution Less skin irritationLess skin irritation

European European Clinical tests demonstrate advantages of Clinical tests demonstrate advantages of Dermoelectroporation® Vs. Iontophoresis for transdermal delivery of Dermoelectroporation® Vs. Iontophoresis for transdermal delivery of radioactive Lidocaineradioactive Lidocaine

Advantages of Transdermal Advantages of Transdermal DeliveryDelivery

of High-Weight Moleculesof High-Weight Molecules No skin damage due to low limited-current No skin damage due to low limited-current

pulsespulses No change in pH due to symmetrical pulse No change in pH due to symmetrical pulse

administrationadministration No adverse effects reportedNo adverse effects reported

European European Clinical tests demonstrate enhanced delivery of collagenClinical tests demonstrate enhanced delivery of collagen and a five-fold increase in transdermal delivery of Eparine and a five-fold increase in transdermal delivery of Eparine using Dermoelectroporation® Vs. application on the skinusing Dermoelectroporation® Vs. application on the skin

Advantages of Advantages of DermoelectroporationDermoelectroporation®®

OnlyOnly with the Transderm with the Transderm®®…… No NeedlesNo Needles No PainNo Pain No Bruising No Bruising No SwellingNo Swelling No DowntimeNo Downtime

...BUT ACHIEVES THE SAME RESULTS AS ...BUT ACHIEVES THE SAME RESULTS AS AN INJECTION!!!AN INJECTION!!!

The Complete SystemThe Complete System

Included:Included: Mattioli Mattioli

Microdermabrasion Microdermabrasion SystemSystem

Two Probes for the Two Probes for the Face and BodyFace and Body

Precision Liquid Precision Liquid DispenserDispenser

Initial SuppliesInitial Supplies

Other ConfigurationsOther Configurations

Face and Body ApplicationsMicrodermabrasion System Not Included

Face Application OnlyMicrodermabrasion System Not

Included

Precision Liquid Dispenser and

Disposable Caps

Probe for Face

Probe for Body

Disposable Accessories

A Sterile SystemA Sterile System

All of the accessories for the Transderm®

come pre-sterilized and individually

wrapped

Physician’s IndicationsPhysician’s Indications

IontocaineIontocaine (lidocaine hydrochloride 2% and epinephrine (lidocaine hydrochloride 2% and epinephrine

1:1000,000)1:1000,000) and other anesthetics prior to and other anesthetics prior to laser procedureslaser procedures

Needle Free MesotherapyNeedle Free Mesotherapy – – Cellulite, Body Cellulite, Body Sculpting, Fat PadsSculpting, Fat Pads

Hyaluronic AcidHyaluronic Acid – – Facial RhytidsFacial Rhytids

Collagen, Elastin, Vitamins and Minerals Collagen, Elastin, Vitamins and Minerals - - Facial RejuvenationFacial Rejuvenation

And More!!!!!And More!!!!!

TransdermTransderm®® ResultsResults

4.33.4

6.7

7.6

0

1

2

3

4

5

6

7

8

10 patients

LMX 5 Ionto + 2% lidocaine Ionto + water Nothing

Pilot clinical study to evaluate the efficacy of the Transdermal Ionto device to minimize pain and

discomfort associated with dermatological cosmetic procedures

Mark Nestor, MD, PhD and Alex CazzanigaCenter for Cosmetic Enhancement, Aventura, Florida

Frequently Asked QuestionsFrequently Asked Questions Q: What is the difference between the various Transdermal Delivery Devices Q: What is the difference between the various Transdermal Delivery Devices

available in the available in the USA?USA?A: The Transderm® is the ONLY system to be FDA Cleared as an alternative to A: The Transderm® is the ONLY system to be FDA Cleared as an alternative to injections. Other systems will be ultrasound devices, muscle stimulators, micro-injections. Other systems will be ultrasound devices, muscle stimulators, micro-current devices, etc. The Transderm® is a medical device, and all medical devices current devices, etc. The Transderm® is a medical device, and all medical devices must have FDA Clearance.must have FDA Clearance.

Q: How deep can we deliver ionic drug solutions with the Transderm®?Q: How deep can we deliver ionic drug solutions with the Transderm®?A: Based on the weight of the molecule, the Transderm® can deliver as deep as A: Based on the weight of the molecule, the Transderm® can deliver as deep as the muscle membranethe muscle membrane

Q: Is the Transderm® only sold to physicians?Q: Is the Transderm® only sold to physicians?A: Yes. The Transderm® has the same clearance as an injection and is only A: Yes. The Transderm® has the same clearance as an injection and is only distributed to physicians.distributed to physicians.

Q: Is the Transderm® painful for the patient?Q: Is the Transderm® painful for the patient?A: No. The Transderm® has a vibration mode which significantly minimizes the A: No. The Transderm® has a vibration mode which significantly minimizes the sensation of the electrical pulses.sensation of the electrical pulses.

Q: Will my patient have any bruising or swelling?Q: Will my patient have any bruising or swelling?A: No. Because there are no needles, there is no pain, bruising or swelling with the A: No. Because there are no needles, there is no pain, bruising or swelling with the Transderm®.Transderm®.

The Transderm IontoThe Transderm Ionto

Manufactured by Mattioli EngineeringManufactured by Mattioli Engineering

Distributed by:Distributed by:

1.888.785.75461.888.785.7546

www.SaratogaAesthetics.comwww.SaratogaAesthetics.com

transderm overview saratoga aesthetics

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