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  • The Bulletproof Executive 2013

    Transcript of Everything You Need To Know About Saturated Fat & Cholesterol with Chris Masterjohn

    Bulletproof Radio podcast #16

  • Bulletproof Toolbox Podcast #16, Chris Masterjohn


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  • Bulletproof Toolbox Podcast #16, Chris Masterjohn


    Dave: Today's cool fact of the day is about yawning. Yawning is actually an involuntary action that most humans do starting even in the womb. We've seen research that says fetuses as young as 11 weeks old start yawning. It turns out that contagious yawning doesn't happen until you're about age four. Even now, scientists haven't quite figured out why when one person yawns after someone else does, it seems to keep propagating to everyone else in the room. There are suggestions that it may be a sign of empathy that helps human beings bond with each other. That means in your next meeting, if you need to yawn, I guess you should.

    You're listening to episode 16 of upgraded self radio with Dave from the Bulletproof executive blog. We have a great interview today with Dr. Chris Masterjohn. Chris is a really well known blogger, writer, and researcher in the health community. Mostly because of his critical thinking, because of his excellent articles, and his really kind of laid back, non-dogmatic approach to nutrition. I really respect Chris and what he has to say and what he has to write, and I'm really pleased to have him on the show.

    He's going to talk with us today about one of the most common myths about health and disease, saturated fat. If you're one of those people who is still avoiding bulletproof coffee and our recommendations for butter and coconut oil because you're concerned about your health, you really want to listen to our conversation with Chris. He's a very rational guy and I think he's in line with the recommendations about saturated fat.

    Co-host: Now we're going to move on to our exclusive interview with Chris Masterjohn from Cholesterol and health dot com.

    Dave: He's the creator and maintainer of, that's with dashes between all of the words. A website dedicated to extolling the virtues of cholesterol and cholesterol rich foods. By the way, you can see why we would have Chris on the show because not only do I read Chris's blog, I absolutely agree with him on these types of things.

  • Bulletproof Toolbox Podcast #16, Chris Masterjohn


    He's authored three publications published in peer reviewed journals, including a letter to the Journal of the American College of Cardiology, criticizing the conclusions of a study on saturated fat. A letter in the American Heart Journal, arguing the safety trials of cholesterylester transfer protein inhibitors, and a vitamin E metabolism. And he's written a full length hypothesis paper that was publish in Medical Hypothesis about the molecular mechanism of vitamin B toxicity. He's also written a review on green tea and non-alcoholic fatty liver disease, which will be published soon in nutrition reviews. He's got a bachelor's degree in history, and is currently a doctoral student in nutritional sciences at the University of Connecticut.

    He is going to be with us here on upgraded self radio today, to help dismantle some of the myths you probably believe about fats, and to provide you with some information that you need to pursue a healthy and more powerful lifestyle.

    Chris, I'm super excited to have you here. Welcome.

    Chris: Yeah. I'm excited to be here. Thank you so much Dave.

    Dave: We're going to take maximum advantage of the time we've got with you on the interview today, so we're going to jump right in.

    Chris: All right.

    Dave: First question. Does saturated fat raise cholesterol levels?

    Chris: Well, it depends on the context. There's pretty clear evidence by going back to the 1950's that if you substitute saturated fat for oils or fats rich in polyunsaturated fat, so for example if you substitute coconut oil or butter for oils such as corn oil, safflower oil and so on, that you'll increase cholesterol levels relative to those other oils. It becomes much less clear if you're trying to compare saturated fat to carbohydrate, such as fat monounsaturated fats, you're looking at much smaller differences and a little bit more complex differences. For example, saturated fat will tend to increase total cholesterol, but will increase HDL cholesterol as well as LDL cholesterol relative to carbohydrate. There's differences in particle size and other things like that.

  • Bulletproof Toolbox Podcast #16, Chris Masterjohn


    It becomes even more complex when you're talking about a diet because if you're saying, "Okay, meat is high in saturated fat." Does eating meat raise your cholesterol or does eating any other types of foods that are rich in saturated fat? Very difficult to say because whenever you make dietary changes you're including a food that has a multitude of components in it besides saturated or unsaturated fat. You're also displacing other foods. Since different foods have different affects on satiety, you could be changing total caloric intake and so on and so forth. So, it would be incredible simplistic to say that saturated fat raises cholesterol levels, but there are certain context in which that statement is true.

    Dave: I read an article by Stephan [Guyenet 00:05:02] a while ago about how a lot of saturated fat increases cholesterol over a short term but over the long term they normalize. Do you have anything to say about that?

    Chris: Yeah. I've talked with Stephan about this a little bit and I think that we're pretty close to agreement with each other on this. If you substitute saturated fat for polyunsaturated fat in a very controlled setting, over the course of the long term the saturated fat will result in higher blood cholesterol levels than the polyunsaturated fat. In the case of ... Nothing's posted about observational studies. This is, of course, looking at a more realistic scenario where people are not in such a controlled setting and they're choosing natural foods and they're doing so over the long term, but it's also in a setting that is much more confounded by all those variables that I was just talking about.

    These people aren't choosing to drink a milkshake that's had its fat replaced with corn oil or something like that, that you might see in a laboratory setting. They're choosing foods like coconut or meat or junk foods rich in saturated fat, natural foods rich in saturated fat, and you have so many other interacting factors. I don't think that those studies ... What he showed was that in these observational studies, there's no evidence that people who have higher saturated fat intake have higher blood cholesterol levels.

    I don't think that's just because it's over the long term, I think it's also because there are so many other variables that enter into play when

  • Bulletproof Toolbox Podcast #16, Chris Masterjohn


    you're in a natural situation. When you're in a highly controlled laboratory situation, things are different and you can isolate those other variables out and show that if you substitute animal fat for vegetable oils and you keep everything the same, then you do see that change even over the long term.

    The best demonstration of that is the LA Veterans Administration Hospital study where they took about 850 men who are inpatients in a veterans residence home and they randomly allocated them to one of two dining halls. The two dining halls, over the course of eight years, fed everyone the exact same food, but in one they used animal fat in the cooking and in the other they used a mix of vegetable oils in the cooking. Even over the course of those eight years, the differences in blood cholesterol levels were sustained over very long periods of time.

    The question is, is that finding relevant? Well, it's not relevant to the point where you can say that any diet that's rich in saturated fats from natural sources is going to lead to higher blood cholesterol levels than some other diet that's rich in vegetable oils. That's not true and that's what Stephan's post showed, that people who eat diets high in saturated fat do not necessarily have higher blood cholesterol levels than other people.

    Dave: Let's say that cholesterol, that saturated fat does raise cholesterol, does that equal heart disease?

    Chris: No, it doesn't because cholesterol doesn't cause heart disease. If you want the clear evidence for this, we can go back to the cholesterol f


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