As a specialty CRO, Numira has set the bar in discovery pharmacology, high-resolution imaging, histology, and analysis of animal models. We provide researchers with quantifiable, visible evidence of disease progression, drug efficacy and drug side effects in their animal models. Key features of our services include:

▪ Experienced team with extensive in-life, imaging, histology, and software expertise

▪ Customized protocols to meet your specific study objectives

▪ Quality control systems to ensure the highest quality on a consistent basis

▪ GLP availability on select services

▪ Comprehensive reporting that integrates all the imaging and quantitative data

▪ Rapid turnaround that supports your need for compressed timelines

Traditional Histology Services

Traditional Histology Services

Full Service GLP Histopathology LabNumira’s full service histology suite offers expertise in many areas. We can provide histology services in conjunction with your in-life studies, as well as provide stand-alone services such as:

Plastic MethodUsed for embedding undecalcified bone or hard implants in soft tissue

▪ Significant experience in bone and implantable medical devices▪ Multiple plastics available to suit the needs of the sample▪ Many routine preparations for typical bone preparation▪ Wide breadth of experience with specialized samples▪ Typical Applications: bone, implantable medical devices, material biocompatibility, polymers and polymer coatings

Paraffin MethodUsed for embedding soft tissue from routine pathology assessments

▪ Routine preparations available for toxicology preparations▪ Many specialized bone preparations▪ Custom sectioning available▪ Wide variety of stains

Coronary Stent (Masson's Trichrome)

Rat Tibia Growth Plate (Safranin O)

Rat Fetus Vessel (CD31)

Kidney 20x (H&E)

Decalcified paraffin section

Plastic thin section

Paraffin section

Paraffin section

© 2011 NumiraTM Biosciences. All rights reserved. N001-0609-1Patents Pending #1003-0911

Corporate Headquarters560 Arapeen Drive, Suite 250Salt Lake City, UT 84108(801) 320-0682

Full Service GLP Histopathology Lab continued

Frozen MethodRequired for specialized preparations and some IHC stains

▪ Expertise in frozen embedding method for specialized applications or tissues▪ IHC staining available and able to develop custom IHC stains as needed

ImmunohistochemistryUsed to interrogate the distribution and localization of biomarkers and differentially expressed proteins

▪ Scientific expertise available to develop custom IHC for a wide variety of markers in paraffin embedded tissues or frozen section

HistopathologyExpert analysis of tissues for quantitative and qualitative manifestations of disease

▪ Board certified Veterinary Pathologist▪ Routine and custom analyses▪ Pathology consulting available

HistomorphometryExpert analysis of the organization and structure of a tissue such as bone using imaging and specialized software applications

▪ Validated Osteomeasure system▪ Routine and specialized imaging (brightfield and fluorescence)▪ Existing routine analyses for common bone types▪ Specialized analyses can be developed to client needs▪ GLP reporting standards when required▪ Static, dynamic, and cellular measurements available to suit client needs

Hard Tissue and Bone SectioningPermits study of mineralized tissue and implants of metallic or ceramic materials

▪ Exakt cutting system (ground sections)▪ Thin sections (microtomy)▪ Oversized samples

Additional Custom ServicesAllowing the highest quality histopathology required to meet our client’s needs

▪ Radiography, microCT, Bioassay, PIXI, DXA▪ Biomechanical testing, pOCT

We are always eager to develop new study protocols. Please contact us at info@numirabio.com to inquire about a development project.

Mouse Ear (H&E)

Mouse Substantia Nigra (TH)

Rat Tibia for dynamic measurement

Metal Implant (Stevene’s Blue)

Paraffin section

Frozen section

Plastic thin section

Ground section