trace mineral importance calf hood immune support - …agebb.missouri.edu/modbu/archives/v16n2/trace...
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Nutrient Requirements for the Immune System
• Energy• Rapid Proliferation of immune cells
• Protein• Cell replication cytokines, and antibodies
• Minerals (Cu, Zn, Se, Mn, Fe, S)
• Vitamins ( A, D, E, C, B complex)
Antioxidant System Energy productionProtein Synthesis
Membrane Integrity
Immune System
• Innate/ Cell mediated Immune Response
• Immediate Response
• Acquired/ Adaptive Immune Response
• Takes Time
SURE Trace Mineral Supply by Timed Injection
Newborn Calf Immune System• Decreased Innate Defense mechanism
• Decreased Acquired Immune mechanism
SURE Trace Mineral Supply by Timed Injection
Pre Weaning Period
Digestive Disorders 25%• 71% Treated Antibiotics
• Respiratory Disease 12-18%• 90% Treated Antibiotics
Respiratory Disease 5.9 -11%• 98% Treated Antibiotics
• Digestive Disorders 0.8 - 1.9%• 88% Treated Antibiotics
Post Weaning Period
SURE Trace Mineral Supply by Timed Injection
Economic impact of scours by case
• Cost of one case of scours# Calves 200Cost/Case $50Incidence % 25%
Expense $2,500
Economic Impact: Disease pre-weaning
• Milk Production• Scours alone
• Not significantly affected• With antibiotic treatment
• 1086 lbs. less milk during the first lactation
$18 CWT: $195.48 100 heifers: $19,548
MANAGEMENT AND ENVIRONMENT FACTORS THAT AFFECT PRODUCTIVITYOF CALVES
M. E. Van AmburghDepartment of Animal ScienceCornell University, Ithaca, NY
SURE Trace Mineral Supply by Timed Injection
SURE Trace Mineral Supply by Timed Injection
Economic Impact: Disease Post Weaning
• Cost of one case of scoursPneumonia: Nationally ; 50 to 55% of deaths
$15.00 /calf/year
Approx: $47.00 / Case# Calves 200Cost/Case $ 47.00
Incidence % 11%
Expense $ 1,034.00
SURE Trace Mineral Supply by Timed Injection
How…………….
• Support the immune System
• Pre-weaning
• Weaned dairy Calf
• 790 Holstein dairy calves
• Colostrum management and rearing systems similar and adequate.
• Calves were not deficient in Se, Cu, Zn and Mn at the start of the study.
SURE Trace Mineral Supply by Timed Injection
Study Design790 dairy calves
Randomly allocated:
- TMS- Control
3 days of age1st injection
1 mlTotal IgG
SODGPx
Haptoglobin
30 days of age2nd injection
1 mlSODGPx
Haptoglobin
Leukocyte phagocytosis activity
Subset: 228 calves
Weekly body weights measurementsDisease diagnosis
45 days of age
weaning
14 days of age
SODGPx
Haptoglobin
Phagocytosis
• 14 days:• MM90 : Increased Neutrophil activity
• ( increased number of ingested bact.) P=.025
• Increased number of neutrophilsthat performed phagocytosis.
SURE Trace Mineral Supply by Timed Injection
How…………….
• Support the immune System
• Pre-weaning
• Weaned dairy Calf
Liver Concentrations of Trace Minerals
0
1
2
3
4
5
6
-7 21 56
Liver
Se
(µg/
g)
Days relative to priming vaccination + ITM (d0 )
Con
ITM
Se reference range: 0.7-2.5 µg/g
* *
P < 0.001
*
*
0
100
200
300
400
500
600
700
800
-7 21 56
Liver
Cu
(µg/
g)
Days relative to priming vaccination + ITM (d0)
Con
ITM
Cu reference range: 50-300 µg/g
P= 0.01
*
**
Significant differences between groups for each day * Significant difference compared to day -7 for each group (P < 0.01)
0
2
4
6
8
10
12
14
16
18
-7 21 56
Liver
Mn
(µg/
g)
Days relative to priming vaccination + ITM (d0)
Con
ITM
Mn reference range: 5-9 µg/g
* **
*
0
50
100
150
200
-7 21 56
Liver
Zn
(µg/
g)
Days relative to priming vaccination + ITM (d0)
Con ITM
Zn reference range: 100-300 µg/g
* * **
Significant differences between groups for each day (P < 0.05)* Significant difference compared to day -7 for each group (P < 0.01)
Liver Concentrations of Trace Minerals
SURE Trace Mineral Supply by Timed Injection
When..• Pre- Weaning
• 1-3 days of age
• 30 days of age
• Post Weaning
• At Primary Vaccination
• At Booster
When was the last time a Buck bought anything ??
SURE Trace Mineral Supply by Timed Injection
# Calves 200 200Cost/Case/Scours $50 $50Incidence % 50% 42%Expense $4,970 $4,170MM90 $200Total $4,970 $4,370
Savings $600