1. To x i c i t y i s t h e e f f e c t t h a t o c c u r s wh e nt o o mu c h o f a d r u g a c c umu l a t e s i n t h eb l o o d s t r e am. T h i s c o u l d b e d u e t o e i t h e r o v e r d o s eo r t h e i n a b i l i t y o f t h e k i d n e y o r l i v e rt o b r e a k d own t h e d r u g . T h e d e g r e e o f h a rmf u l e f f e c t s v a r i e sdependin g o n t h e d r u g a n d t h e d o s e ,b u t t h e y c a n b e l i f e - t h r e a t e n i n g .

2. When the blood plasma level of the drug is below the minimumeffective concentration, no therapeutic effect occurs. The therapeutic range falls between the MCE and the toxicconcentration. This is where the blood plasma level of the drugis intended to be. The toxic concentration indicates the concentration of the drugthat is not safe to be in the bloodstream. 3. WHAT DOES ACETAMINOPHEN TOXICITY DO TOTHE LIVER? Damage to the liver occurs between 72-96hours after acetaminophen ingestion. Hepatic necrosis occurs, along with hepaticdysfunction. If treatment is not received, multi-organ failureis possible. (Farrell, 2014) 4. HOW TO PREVENT TOXICITYAlways take drugsas directed.Do not exceedmaximum dosage.Know the dosage ofdrug per tablet.Know how often to takethe medication.Know what othermedications toavoid while takingTylenol.Acetaminophen is inover 600 medications,thus it is easy to exceedthe therapeutic dose(Tylenol, 2014). 5. REFERENCESFarrell, S. E. (2014, June 24). Acetaminophen Toxicity . Retrieved September 1, 2014, from Medscape:http://emedicine.medscape.com/article/ 820200-overviewTylenol (2014). Frequently asked questions. Washington, PA: McNeil-PPC, Inc. Retrieved from Tylenol:http://www.tylenol.com/safety-dosing/faq#safety-dosingTylenol (2014). Acetaminophen dosage for adults. Washington, PA: McNeil-PPC, Inc. Retrieved fromhttp://www.getreliefresponsibly.com/acetaminophen-dosage/adults?utm_source=google&utm_medium=cpc&utm_campaign=GRR+-+Unbranded&utm_term=acetaminophen%2520dosage&utm_content=Acetaminophen+-+Dosing|mkwid|s1RXEK6GM_dc|pcrid|27714131282|338ilu23432Lehne, R. A. Parmacology for Nursing Care. St. Louis, Missouri, U.S.: Elsevier.Mehta, N. (2012, June 27). Drug-Induced Hepatotoxicity. Retrieved September 2, 2014, from Medscape:http://emedicine.medscape.com/article/169814-overview#aw2aab6b3