tmc final schemdi
DESCRIPTION
SchematicTRANSCRIPT
Molo, Iloilo City Tel No.: (33) 338-1507 [email protected]
Predisposing factors
Precipitating factorschange in urine ph (alkaline)
Dehydration
Sex (female)
Diet
Age ( between 30-50 y.o)
Lifestyle
UTI
Bacteria enters urinary tract(Proteus, Pseudomonas, Klebsiella, Staphylococcus, Mycoplasma)
Urease from bacteria degrades urea to ammonia and CO2Ammonia hydrolyzes to ammonium
(NH3 to NH4)
Increased urine pH (Alkaline)CO2 hydrates to bicarbonate(H2CO3)
Dissociates to carbonate that precipitates with calcium as calcium carbonate(CaCO3)
Ammonium precipitates with phosphate and magnesium
Formation of struvite
RENAL CALCULI ( NEPHROLITHIASIS)Urinary stasis/high concentrations of these substances result in calculus growth
Calculi block the flow of urine
Calculi continue to increase in size
Bacterial growth from pooling of urine
Toxins from bacteria affect biochemical
receptors in cells
Disruption of normal cell functions or
cell death
Tissue injury Flank pain
fever
Injured tissue became infected
WBC invaded the infected tissue
Purulent exudates consisting of inflammatory cells,
infectious organism, WBCs collects in the renal pelvis.
Renal Calculi prevents the exudates from draining
Pus in the renal pelvis accumulates
PYONEPHROSISDiet
Lifestyle
UTIs
Urinary stasis
Age (30-50y.o.)