Title of Poster Title of Poster

ABSTRACT:

INTRODUCTION:

Strategies :

Acknowledgements:

• Bonnie Kaiser

• Joseph Alonzo

• Deanna Russell

• Scott LKJDSFHLSFDHHKLDSF:HKL:FSDHK:LFSDHLK

• All the members of the Friedman Lab

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ABSTRACT:

Prevalence: After the modernization of a nation the instance of obesity within that population becomes much higher. Obesity and its related health disorders: hypertension dyslipidemia, type II diabetes, coronary heart disease, stroke, gallbladder disease, osteoartheritis, sleep apnea, respiratory problems, and certain cancers (endometrial, breast, and colon) are reaching epidemic proportions. The prevalance of obesity has increased from 15% of the adult population in 1980 to 33% in 2004. This has brought obesity to the forefront of the medical and research community’s attention. (National Center for Chronic Disease Prevention and Health Promotion, 2007)

Fat Sensing: The body’s ability to sense and and regulate caloric intake is incredibly accurate, despite the recent rise in obesity. (Bray, 1976) The hormone leptin was cloned by Jeffery Friedman at The Rockefeller University in 1994 after it was known to play a signifigant role in fat sensing. Leptin is produced by adipose tissue, mainly white adipose tissue (WAT) from where it travels to the brain through the blood system. In the brain leptin acts mainly in the hypothalamus, but affects many areas of this gland which affects body temperature, hunger, and thirst. It is known that leptin has an anoerectic affect when injected directly into the arcuate nucleus of the hypothalamus, setting up a negative feedback loop. Simply, as one increases caloric intake, adipose tissue is generated, WAT secretes leptin which reduces caloric intake.

Obesity:Receptor Deletions

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