Tissues and OrgansComprising the Immune

Response System

Where components of the immune responseoriginate,

differentiate, meet,

interact, and function

Folder Title: Tiss&OrgUpdated: October 30, 2013

APC and T-Cells

Marcophage and T-Cell Kissing

Macrophage to T-Cell Interaction

Helper T-cell B-Cell Interaction

CD4 co-receptor

B-Cell Activation

See figure 2-7,Kuby, 4th Ed.,p. 36

B-Cell: Small, Blast, and Plasma

See Figure 2-7,Kuby 4th Ed.p. 36

Where do these cells originate?

Where do they go to interact with each other?

Where do they carry out their functions?

Primary and Secondary Lymphoid

Related to Figure 2-13, Kuby, 4th Edition, p. 47

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Chapter 2 Animation. Cells and Organs

Please put away all notes and any devices except for your Turning Point NXT Transmitter.

No papers or computers on your desk please.

No communication between or among students.

Exactly* what kind of Cell is the one attached to the B-Cell? (exactly means not just its general type of cell, but

specifically what it is based on what this figure shows.)Rank Responses

1

2

3

4

5

6 Other

What is the blue thing that looks like an alligator clip on the cell attached to the macrophage or to the B-cell?

Rank Responses

1

2

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6 Other

What is the purple thing that looks like a hook on the cell attached to the macrophage or to the B-cell?

Rank Responses

1

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6 Other

Thymus Photo

Thymus Cartoon

Diagrammatic Cross Section of Thymus. Figure 2-14, Kuby, 4th Edition, p. 48 ThymusCross

CD4 and CD8 in Thymus

MALT and M-CellsSee Figure 2-22, Kuby 4th Ed.

p. 56

MALT and IgA

See Figure 2-22Kuby, 4th Ed.p. 56

CD Antigen Table

CDMarks

CD Antigens Color Coded

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Chapter 11 Animation. Signal Transduction

CD Antigen List: Pages A1 to A26: 339 Entries, 2007 Edition of Kuby

How to Understand CD Antigens: 5 Persons in a Room

Person 1: 5 ft 5”, 160 lbs bespectacled old geezerPerson 2: 5 ft 11”, 280 lbs, 22-year old guy, all musclePerson 3: 5 ft 5”, 135 lbs, 20-year-old womanPerson 4: 7 ft 1” , 200 lbs, 22 year-old guyPerson 5: 5 ft 8”, 150 lbs, 22 year-old guy

This is a fill-in-the-blank question. Please enter your responses as a series of numbers from 1 to 5.

Which Person:A. Is a varsity basketball player?

B. Plays on the women’s field-hockey team?C. Is a boring old professor?

D. Is a varsity football player for SU?E. Is a cross-country runner?

__ __ __ __ __

Person 1: 5 ft 5”, 160 lbs bespectacled old geezerPerson 2: 5 ft 11”, 280 lbs, 22-year old guy, all musclePerson 3: 5 ft 5”, 135 lbs, 20-year-old womanPerson 4: 7 ft 1” , 200 lbs, 22 year-old guyPerson 5: 5 ft 8”, 150 lbs, 22 year-old guy

Secrets of Signaling

1. How Do You Knock on a Door?

2. Why does the phone “ring” more than once?

3. Why does the police officer blow his whistle only once?

4. Why does your computer say “Are You Sure You Want to Delete File XYZ?

5. When Ashley Nieves asked the class to raise their right hand, why did only eleven persons out of 95 respond?

6. Why did a different set of students respond to the same message when InSu Jo made the request?

Signal, Receptors, and co-receptor Pairs

Costimulatory signals: B7 – CD28

Costimulatory Signals: T-Cell to MPh

Cancer Eluding Costimulatory Signal

CD’s on B, T, and NK Cells

T-Cell ALL Markers

Kuby, 5th Editionp. 157

(“ALL” = Acute Lymphocytic Leukemia)

Pre-B-Cell ALL Markers

Kuby, 5th Editionp. 157

(“ALL” = Acute Lymphocytic Leukemia)

B-Cell CLL Markers

Kuby, 5th Editionp. 157

(“CLL” = Chronic Lymphocytic Leukemia)

Leukocyte Recirculation

Lymphocyte Recirculation

Leucocytes in Capillaries Cartoon

Leucocytes in Capillaries Photo

Extravasation of Naïve T-Cell into Lymph Node

Adhesion: Leucocytes to Endothelium

(Non-inflamed Endothelium)

(Inflamed Endothelium)

CAM = Cell Adhesion Molecules

General Structures ofCell Adhesion Molecules (CAMs) Kuby, 3rd Edition Figure 15-2a

Endothelial Cells

Lining Capillaries

CAMStruct

Membrane of CirculatingLeucocytes

Actin Cytoskeleton Linkage to Collagen Extra-cellular Matrix

Figure 19-14 ECB

1998, p. 603

Plasma Membrane

Collagen

Integrin

Fibronectin

Actin Microfilament

MFtoECM

CAMinCap Adhesion in Capilaries

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http://bcs.whfreeman.com/immunology6e/

Chapter 13 Animation. Leukocyte Extravasation

When a leukocyte traveling in the blood-stream enter the capillary circulation in a tissue that is under bacterial attack, which of the following

happen? The system should accept four correct answers

The l

euco

cyte

imm

ediat

ely d

egr..

.

The l

eukocy

te goe

s into

cell d

ivi...

The l

eukocy

cte bin

ds to t

he cap

il...

The l

eukocy

te ro

lls al

ong the e

n...

The l

eukocy

te eli

cits m

embra

ne ...

The e

ndotheli

al ce

lls th

en en

ter ...

The l

eukocy

te ex

trava

states

The l

eukocy

te m

akes

antib

odies

0% 0% 0% 0%0%0%0%0%

1. The leucocyte immediately degranulates2. The leukocyte goes into cell division3. The leukocycte binds to the capillary

endothelial cells (High endothelial venules)4. The leukocyte rolls along the endothelial

lining.

5. The leukocyte elicits membrane signals from the endothelial cells that bind the leukocyte tightly.

6. The endothelial cells then enter apoptosis7. The leukocyte extravastates8. The leukocyte makes antibodies

Response

Counter

On a scale from –2 to +2(Use #1 on Key-pad) -2 = I’m lost;

(Use #2 on Key-pad) -1 = I’m having a hard time, but I follow some of it.(Use #3 on Key-pad) 0 = I’m doing OK. I uderstand most of it.

I can figure the rest out later.(Use #4 on Key-pad) +1 = I’m following OK. No problem

(Use #5 on Key-Pad) +2 = This is pretty straight-forward, Please move on.

1

2

3

4

5

Duration: 0 Seconds

If a red blood cell is an erythrocyte, what is a T-cell?_________________ cyte

1 2 3 4 5 6

17% 17% 17%17%17%17%

Rank Responses

1

2

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6 Other

Which of the following are Primary Lymphoid Organs?(Two responses should be accepted by the system)

Muco

sal a

ssocia

ted ly

mphoid

tis..

.

Ton

sils

Aden

oids

Thym

us

Thyro

id

Bon

e mar

row

Cer

vical ly

mph nodes

Splee

n

Lum

bar lym

ph nod

es

0% 0% 0% 0% 0%0%0%0%0%

1. Mucosal associated lymphoid tissue (MALT)

2. Tonsils

3. Adenoids

4. Thymus

5. Thyroid

6. Bone marrow

7. Cervical lymph nodes

8. Spleen

9. Lumbar lymph nodes

Response

Counter

T-Cells are lymphocytes that are “educated” in the

Ton

sils

Toe

-nail

s

Tee

th

Thyro

id

Thym

us

Tes

ticles

Thora

cic D

uct

Non

e of t

he ab...

0% 0% 0% 0%0%0%0%0%

1. Tonsils

2. Toe-nails

3. Teeth

4. Thyroid

5. Thymus

6. Testicles

7. Thoracic Duct

8. None of the aboveRespons

e Counter

CAMFamlyOn EndothelialCells

On Neutrophils

On Mucosal Epithelium

On Leucocytes

On EndothelialCells

On Leucocytes

On EndothelialCells

Families ofCell AdhesionMoleculesKuby, 3rd Ed.Figure 15-2bCamFamly

On a scale from –2 to +2(Use #1 on Key-pad) -2 = I’m lost;

(Use #2 on Key-pad) -1 = I’m having a hard time, but I follow some of it.(Use #3 on Key-pad) 0 = I’m doing OK. I uderstand most of it.

I can figure the rest out later.(Use #4 on Key-pad) +1 = I’m following OK. No problem

(Use #5 on Key-Pad) +2 = This is pretty straight-forward, Please move on.

1

2

3

4

5

Duration: 0 Seconds

How Well Are You Following What is Being Presented so Far in theCourse?

(This will be set to anonymous so you will not be identified and your response will not be graded)

1. I’m totally lost.

2. I’m having hard time, but I follow some of it.

3. I’m OK. I can figure most of it out later.

4. I’m following very well. There is no problem with the level of the course.

5. This isn’t pitched at a level appropriate for an upper division undergraduate course. Please move to a higher level of challenge.Response

Counter

AnimationsProduced for Kuby Immunology

http://bcs.whfreeman.com/immunology6e/

Or search “Kuby Immunology”, Click on “Kuby Immunology 6e” , go to Student Resources

Chapter 2: Cells Cell Death (Also chapter 10)

Chapter 11: Signal TransductionChapter 13: Leucocyte Extravasation