Tips of daily care for seniors: How to prevent age-related diseases and live healthier and longer?

Dinghua Wang OMD.Ph.D

Amkey, Inc.

April 6th, 2004

Revolutional Breakthrough:First Cloning--Sheep Dolly

Raise the hopes:1. Living forever 2. No need for surgery or drugs, simply replacing sick parts (brain, heart, kidney, liver, arms, legs) with a clone (no immune rejection)3. Creating super-intelligent people

How to clone?

Only female is needed to clone, male is no use.

Human lifespan has been extended from 46.5 years in 1950s to 65.2 years, especially in developed countries

such as USA, Japan, Europe to more than 80 years (China 71 years) in 2002

过去 :人生 70古来稀如今 :人生 90不稀奇

Not only live longer, but also healthy

The healthy lifespan (until you are sick and disable)

Top 10 nations: Australia, 73.2 years; France, 73.1; Sweden, 73.0; Spain, 72.8; Italy, 72.7; Greece, 72.5; Switzerland, 72.5; Monaco, 72.4; Andorra, 72.3.

Bottom 10 countries: Sierra Leona, 25.9; Niger, 29.1; Malawi, 29.4; Zambia, 30.3; Botswana, 32.3; Uganda, 32.7; Rwanda, 32.8; Zimbabwe, 32.9; Mali, 33.1; and Ethiopia, 33.5.

Differences are really great!

Why people age?(More than 300 theories and

hypothesis)

1. Toxicity accumulation2. Free Radical

(Oxidative damage)

Free Radical Theory of AgingFree Radical Theory of AgingFree Radical Theory of AgingFree Radical Theory of Aging

Normal metabolismNormal metabolism正常代谢正常代谢

ORGANISMS ORGANISMS 生物生物

Generation of oxidants in mitochondriaGeneration of oxidants in mitochondria在线粒体在线粒体中产生自由基

Accumulation of oxidative damageAccumulation of oxidative damage氧化损伤累积氧化损伤累积

Major contributor to aging & Major contributor to aging & age-associated diseasesage-associated diseases衰老及衰老相关疾病发生衰老及衰老相关疾病发生

人体组织的不同层次 Organismal Level:

What do your body made of and How does it work?

人体系统器官组织细胞

1. Decreased cardiolipin levels and structural deficit; 2. Decreased membrane potential (the driving force for ATP synthesis) and cellular oxygen consumption; 3. Increased oxidation and heterogeneity;4. Prone to oxidative damage, leading to a vicious cycle.

Mitochondria decay with age

Free Radical Theory of Aging

Oxygen is a double-edged sword: We need it to survive, but we are killed by it at the end.

O2 O2-. H2O2 .OH H2O

老年性痴呆 : 渐进性大脑退行性萎缩主要表现 : 记忆衰退 , 至大段忘记 , 全面痴呆目前全球的状况及重要性 :

老年性痴呆 (Alzheimer’s Disease)

在美国有四百余万的老年痴呆症患者 , 70% 的老年痴呆症患者在家接受护理，在疗养院的住院者中，有 69% 到 70% 的人患有各种形式的痴呆。在 60 岁以上的人口中有 6% 的人患有这种病， 75 岁以上人口的发病率则达到 20% 。估计到 2050 年，美国 65 岁以上老人中将有 1400 万人患老年痴呆症。 AD 的致死致残率极高。已成为中老年人中最主要疾病，为第四位死亡原因。 65 岁以上 , 年龄增加 5 岁 , 发病率就将近增加一倍。 30 岁以后的任何年龄均可发病 , 50 岁以后者居多 , 女性略高于男性。美国婴儿潮时期的一批人现在正时进入老年时期，引起美国政府的高度重视，并投入大量资金进行抗衰老研究。美国前三位总统夫人， 3 月 24 日在华盛顿也募捐资金为抗衰老研究推波助澜，说明了衰老性疾病已是全社会的不可忽视的重大问题。

Neuron degeneration 老年性痴呆 , 帕金森氏病 Mental health conditions Diabetes 糖尿病 Cardiovascular diseases 心血管疾病 ( 如高血压 , 心肌梗塞)

Musculoskeletal conditions (such as arthritis and osteoporosis) 骨关节疾病

Cancer 肿瘤

Major chronic conditions affectingolder people worldwide :衰老与衰老相关的疾病有哪些 :

WHAT IS ALZHEIMER'S DISEASE? Alzheimer's disease is a degenerative disease of the brain. The disease slowly attacks nerve cells in all parts of the brain, thereby impairing a person's abilities to govern emotions, recognize errors and patterns, coordinate movement, and remember. At the last, loses all memory and mental functioning. The early symptoms of Alzheimer's disease may be overlooked because they resemble signs of natural aging. These symptoms include forgetfulness, loss of concentration, unexplained weight loss, and motor problems, including mild difficulties in walking. In healthy individuals, similar symptoms can result from fatigue, grief or depression, illness, vision or hearing loss, the use of alcohol or certain medications, or simply the burden of too many details to remember at once. But when memory loss worsens, family and friends perceive that more serious problems exist.

Alzheimer’s Association Gala unites nation’s first ladies, raises more than $1 million

                                                            

“America’s Great Generations Gala” at the J.W. Marriott Hotel in Washington, D.C., March 24.

April 2, 2004

Researchers uncover racial, ethnic variations in Alzheimer's studies*Japanese who live in Hawaii are at greater risk of getting Alzheimer's disease than Japanese living in Japan or in mainland United States. *Elderly Chinese may be more difficult to diagnose with dementia because of cultural practices and stigma attached to mental illness.Source: The Hartford Courant

What is Parkinson's disease?

Parkinson's disease (PD) is a slowly progressive disorder that affects movement, muscle control, and balance. Although it is clear that dopamine deficiency is the primary defect in Parkinson's disease, it is not clear what causes dopamine loss. Resent research shows Mitochondria complex I dysfunction is one of the reasons.

What is Mitochondria?

Caloric restriction make life 30-40% longer!

Caloric restriction can also reduce body weight

----Keep you slim!

Search for Caloric Restriction Mimetics:

That means you can still enjoy your food but also live longer.

0

50

100

Ch

ang

e in

C

han

ge

in

(%

(%

Ch

ang

e R

elat

ive

to Y

ou

ng

)C

han

ge

Rel

ativ

e to

Yo

un

g)

Yo

un

gY

ou

ng

Old

Old

Old

Old

Tre

ated

Tre

ated

能量合成能力能量合成能力

****

Tips for how to live longer and healthier:

Healthy Life Span can be extended by many ways, including to:1. Have a balanced diet, 2. Eat less, 3. Do more exercise, 4. Relax from stress, 5. And so onHowever, if you can not do so but you still want to live healthy to 120 years, you still can! Because…

Mark Twain’s Quotation马克 . 吐温语录

“ The main distinguishing characteristic between man and the lower animals is the

desire to take pills”

Conclusion: Your life is on your hands!

1. 56% of middle-aged and elderly people are taking one or more dietary

supplements.2. With the coming era of baby-boomers

entering old age, there will be a greater need. 3. Thousand and thousand of products now, you

should know what you need. Our products

are more scientific and focus on brain. We are in the frontier of nutritional

science.

The American dietary supplement

AcknowledgeThanks to many scientists who have worked in these institutions. Last but not least, Thanks all of you for your attentions.