thursday 15 december 2016 poster session 14:45 - 16:15

Thursday 15 December 2016 Poster Session 14:45 - 16:15

- Cardiovascular and Respiratory Pharmacology

PB138 Investigating the neutrophil dependence of platelet recruitment to lungs

inflamed by lipopolysaccharides

S. C. Pitchford, S. J. Cleary, S. Arnold, B. G. O'Shaughnessy, R. T. Amison, C.

Hobbs, C. P. Page

King's College London, UK

PB139 A novel role for KATP channels in the mechanism underlying DHA and EPA

(fish oils)-mediated relaxations in rat aorta and mesenteric arteries.

R. Limbu, G. S. Cottrell, A. J. McNeish

University of Reading, UK

PB140 Heme Oxygenase (HO)-1 induction prevents endoplasmic reticulum stress-

mediated endothelial cell death and dysfunction.

A. Agouni1, H. Maamoun2, M. Zachariah2, J. McVey2, F. Green2 1Qatar University, Qatar, 2University of Surrey, UK

PB141 The role of ca2+/calmodulin kinase II in tiotropium bromide mediated

cardiotoxicity

S. Cassambai, S. Dean, K. L. Harvey, C. J. Mee, A. Hussain

Coventry University, UK

PB142 Isolation and functional analysis of reticulated platelets

M. A. Hayman, P. C. Armstrong, M. V. Chan, T. D. Warner

William Harvey Research Institute, UK

PB143 Uncovering the pharmacology of GPR75: Role in pulmonary arterial

hypertension

J. Iyinikkel, D. Thompson, J. N. Hislop, F. Murray

University of Aberdeen, UK

PB144 Double edged effects of arsenic trioxide (As2O3): antileukemia and

cardiovascular toxic effects

Y. Zhang. Pharmacology Department

Harbin Medical University, China,

PB145 Modulation of aortic perivascular adipose tissue function by peroxynitrite

S. Kennedy, A. B. Ugusman, H. Alganga, T. A. Almabrouk

University of Glasgow, UK

PB146 Post reperfusion activation of a1 adenosine receptors protects the

myocardium from ischaemia reperfusion injury

J. Bhandal, J. Buckley, D. Renshaw, H. Maddock, A. Hussain


PB147 The effect of aging on ischaemia-reperfusion injury and cardioprotection

R. K. Raja Idris, H. Maddock, J. Tallis, M. Gharanei


PB148 Atypical antipsychotic-induced metabolic toxicity: characterisation of

mechanisms using an in vitro human adipocyte model

S. Sadiq, D. Dickens, L. McEvoy, M. Pirmohamed, S. Pushpakom

University of Liverpool, UK,

PB149 The TMEM16A-specific inhibitor MONNA is an important regulator of rat

coronary artery function

H. Askew Page1,2, T. Dalsgaard2, S. Olesen2, I. Greenwood1,2 1St. George's University of London, UK, 2University of Copenhagen, Denmark

PB150 The comparison of the effect of several carbocyclic nucleoside analogues

as novel selective NCX inhibitors in mammalian hearts

N. Jost1, A. Geramipour1, Z. Kohajda2, J. Prorok1, Z. Szakonyi1, K. Orawecz1, Z.

Marton1, N. Nagy2, A. Toth2, L. Virag1, A. Varro1 1University of Szeged, Hungary, 2Hungarian Academy of Sciences, Hungary

PB151 Expression and function of Gs-coupled GPCRs in human lung fibroblasts -

activating the cAMP pathway for anti-proliferative effects

M. J. Roberts1, T. C. Kent2, S. J. Charlton1, E. M. Rosethorne1 1University of Nottingham, UK, 2Novartis Institutes for Biomedical Research,

UK

PB152 Type II diabetes mellitus and aging induce blood-brain barrier leakage

R. Loiola, G. Purvis, C. Thiemermann, E. Solito

Queen Mary University of London, UK

PB153 Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates

cardiomyocyte hypertrophy through CD44

F. Mraiche1, N. Abdulrahman1, L. Fliegel2, A. Gadeau3 1Qatar University, Qatar, 2University of Alberta, Canada, 3INSERM, France

PB154 Long noncoding RNAs: a new mechanism in long QT syndrome

Y. Bai

Harbin Medical University, China

PB155 Repurposing calcilytics for inflammatory lung diseases

P. L. Yarova1, M. Schepelmann1, E. J. Kidd1, W. R. Ford1, K. J. Broadley1, J. P.

Ward2, C. J. Corrigan2, P. J. Kemp1, D. Riccardi1 1Cardiff University, UK, 2King's College London, UK

PB156 Tricyclodecan-9-yl-xanthogenate blocks KCNQ1/KCNE1 with high affinity

and specificity

M. Wu1,, H. Luo1,, J. Xu2, T. Takumi3, M. Kameyama2, W. Song1, 1Kumamoto University, Japan, 2Graduate School of Medical and Dental

Sciences, Japan, 3RIKEN Brain Science Institute, Japan

PB157 Blood microsampling as a refined model of thromboembolism in vivo

F. Rauzi1, S. Cleary2, E. Smyth1, C. P. Page2, S. C. Pitchford2, M. Emerson1 1Imperial College London, UK, 2King’s College London, UK

PB158 Impact of Paroxetine on Proximal β-adrenergic Receptor Signaling

S. Guo, R. L. Carter, D. G. Tilley

Temple University Lewis Katz School of Medicine, Philadelphia

PB159 Blocking kinin B1 receptors reduces neointimal formation after vascular

injury in mice

D. Wu1, S. Nasseri1, M. Gurusamy1, A. Ambade1, D. Reddy1, B. Jung2, H.

Doods2 1Chonbuk National University, Republic of Korea, 2Boehringer Ingelheim

Pharma GmbH, Germany

PB160 Does the bone hormone osteocalcin suppress inflammation within human

aortic endothelial cells?

S. A. Millar, S. I. Anderson, S. E. O'Sullivan

University of Nottingham, UK

PB161 Effects of paracetamol on vascular COX-1 and renal COX-2 pathways

responsible for cardiovascular protection

A. S. Nair, H. H. Gashaw, J. A. Mitchell, N. S. Kirkby

Imperial College London, UK

PB162 Pharmacological assessment of ibuprofen arginate in human platelet

function and cancer cell apoptosis

B. Ahmetaj-Shala1, C. Constantinou1, R. Leszczynski1, M. V. Chan2, H. H.

Gashaw1, G. Galaris1, T. D. Warner2, N. S. Kirkby1, J. A. Mitchell1 1Imperial College London, UK, 2Queen Mary University of London, UK

PB163 Effects of tobramycin on lung fibroblast function and extracellular matrix

remodelling

T. Murray, S. Edgar, J. Shute

University of Portsmouth, UK

PB164 Steroid-enhancing casein kinase inhibitors: a new class of anti-

inflammatory anti-fibrotic agents?

A. G. Stewart, M. Li, C. Keenan, C. Xia, S. Y. Langenbach, J. Mangum, T.

Harris

University of Melbourne, Australia

PB165 Urinary PGE-M: PGI-M ratio is elevated in chronic kidney disease in cats

D. Bishop-Bailey1, L. Pelligand1, C. Hyde2, J. Elliott1 1Royal Veterinary College, UK 2Bio-Analysis Centre, UK

PB166 Small-molecule biased formyl peptide receptor agonist compound 17b

protects against myocardial ischemia-reperfusion injury in mice

C. Qin1, L. May2, R. Li1, N. Cao1, S. Rosli1, M. Deo1, A. E. Alexander1, D.

Horlock1, J. Bourke2, Y. H. Yang3, A. G. Stewart4, D. M. Kaye1, X. Du1, P.

Sexton5, A. Christopoulos2, X. Gao1, R. H. Ritchie1 1Baker IDI Heart and Diabetes Institute, Australia, 2Monash University,

Australia, 3Centre of Inflammatory Diseases, Australia, 4University of

Melbourne, Australia, 5Monash University, Australia

PB167 Prevention of contrast-media induced renovascular toxicity using lipid

nanoparticle encapsulation

R. Donaghey, V. A. Ferro, P. Coats, A. B. Mullen

University of Strathclyde, UK,

PB168 TRPA1 channels in brain capillary endothelial cells mediate functional

hyperemia underlying neurovascular coupling.

H. A. Pritchard, P. W. Pires, S. Earley

University of Nevada, Reno

PB169 Modulatory effect of oral anti-diabetic drugs on vascular and

hemodynamic dysfunction induced by high-calorie diet in rats

M. A. Khatib, E. I. Saad, H. H. Fouad, A. F. El-Yazbi. Alexandria University,

Egypt

PB170 LncRNA H19 mediating premature senescence of c-Kit+ cardiac progenitor

cells was attenuated by melatonin

B. Cai, W. Ma, C. Bi, L. Zhang, Q. Huang, F. Ding, Y. Li, F. Yang, G. Yan

Harbin Medical University, China

PB171 Kolaviron prevents ischaemic-reperfusion injury through activation of

Akt/PKB and inhibition of p38MAPK, PARP, Caspase 3 signalling pathways

A. A. Oyagbemi1, D. Bester2, J. Esterhuyse2, O. E. Farombi1 1University of Ibadan, Nigeria, 2Cape Peninsula University of Technology,

South Africa,

PB172 Saturated fatty acids-induced metabolic stress leads to biased effector

memory CD4+ T cell differentiation via mTORC1-independent, PI3K

p110δ/Akt-mediated signals

C. Mauro


PB173 Simvastatin reduces interleukin-1 beta secretion from peripheral blood

mononuclear cells when treated wiht cholesterol crystals

M. Lucitt, N. Gangadharan, P. Kavanagh, P. Walsh, L. Hemeryck, J. Kieran,

M. Barry

Trinity College Dublin, Ireland

PB174 Impact of ageing and hypertension on vasorelaxation to positive

modulators of calcium-sensing receptors

V. Ho

St George's University of London, UK

PB175 The type 2A protein phosphatase regulatory subunit alpha4 is a novel

inhibitor of apoptosis in cardiomyocytes

J. Cowan1, M. R. Longman1, P. Eaton2, A. K. Snabaitis1 1Kingston University, UK, 2King's College London, UK

PB176 Pharmacological inhibition of NLRP3 inflammasome exerts beneficial

effects against ischaemia/reperfusion injury in the rat heart by local

improvement of protective signaling pathways

F. Chiazza1, R. Mastrocola1, C. Penna1, D. Nigro1, F. Tullio1, G. Alloatti2, M.

Cocco1, M. Bertinaria1, P. Pagliaro1, M. Aragno1, C. Thiemermann3, M.

Collino1 1University of Turin, Italy, 2University of Turin, Italy, 3Queen Mary University

of London, UK

PB177 Simvastatin prevents KATP channel-mediated vasodilation in pulmonary

hypertension

M. Absi, M. Al-Chawishly, N. Ashton, G. Hart, A. Gurney

The University of Manchester, UK

PB178 Neither phentolamine nor prazosin behave as classical competitive

antagonists against noradrenaline-induced contractions in the porcine

isolated splenic artery

A. Abdulrahman, H. Denfria, R. Mahajan, S. Chan, V. Wilson

University of Nottingham, UK,

PB179 Lithium ions selectively enhances contractions of porcine isolated splenic

artery to high concentrations of phenylephrine and L-

erythromethoxamine

S. Yahya, A. Abdulrahman, S. Rayment, R. Mahajan, J. Scholefield, S. Chan,

V. Wilson


PB180 The role of extracellular vesicles as markers and mediators of ANCA

vasculitis

K. M. Scullion, B. Vliegenthart, W. Oosthuyzen, E. Morrison, R. Moorhouse,

A. Czopek, N. Dhaun, J. W. Dear

University of Edinburgh, UK

PB181 Inhibition of mitochondrial complex III attenuates thromboxane-mediated

contractions of porcine coronary artery through activation of AMP kinase

M. Saarti, R. Roberts


PB182 Biofunctionalized instructive polycaprolactone scaffolds for the specific

recruitment of blood endothelial cells

I. Marei1, Y. Tsan Tseng2, J. Sohier3, M. Gabriel4, H. A. Saleh4, C. Triggle5, M.

Yacoub1, J. Mitchell1, A. Chester1 1Imperial College London and Qatar Foundation, UK, 2Imperial College

London, UK, 3Institute for the Biology and Chemistry of Proteins, France, 4Qatar Cardiovascular Research Center, Qatar, 5Weill Cornell Medical

College Qatar, Qatar,

PB183 Antioxidant Tiron protects against doxorubicin-induced cardiotoxicity

O. Chiuzbaian, M. Gharanei, C. Mee, H. Maddock, E. Hatch


PB184 Does two-pore channel-one play a role in the response of the heart to

beta-adrenergic signalling?

H. Jackson, L. Elson, S. Rakovic

Oxford University, UK

PB185 Synergistic interaction of lithium ions with L-erythromethoxamine and

phenylephrine contractions in porcine blood vessels: no role for inhibition

of inositol monophosphatase

S. Yahya, R. Mahajan, V. Wilson


PB186 The impact of P450 oxidoreductase knock out on systemic exposure to

rosuvastatin, atorvastatin and atorvastatin metabolites

R. M. Turner1, M. Bayliss1, D. Carr1, N. Kitteringham1, C. J. Henderson2, M.

Pirmohamed1

1University of Liverpool, UK, 2University of Dundee, UK

PB187 α-Calcitonin gene-related peptide protects the vasculature in L-NAME-

induced hypertension

F. Argunhan, A. A. Aubdool, E. Wilde, S. D. Brain


PB188 Use of cAMP-Epac reporter mice to explore prostacyclin signaling in

cardiac myocytes: a proof of concept study

V. Auyeung, P. T. Wright, I. Diakonov, I. Effendi, H. H. Gashaw, N. S. Kirkby,

J. Gorelik, J. A. Mitchell

Imperial College London, UK

PB189 Regulation of the type 2A protein phosphatase-alpha4 signalling axis in

cardiac health and hypertrophy

O. Eleftheriadou1, A. Boguslavskyi2, M. R. Longman1, J. Cowan1, A. Ryan1, B.

E. Wadzinski3, M. J. Shattock2, A. K. Snabaitis1 1Pharmacy and Chemistry, Kingston University, UK, 2King's College London,

UK, 3Vanderbilt University, USA

PB190 Effect of TPS, a peptide designed to specifically recruit blood outgrowth

endothelial cells, on a novel smooth muscle cell phenotype derived from

human blood

I. Marei1, D. Al Dabhani12, Z. Nikolakopoulou1, H. Gashaw1, A. Chester1, J.

Mitchell1 1Imperial College London and Qatar Foundation, UK, 2Weill Cornell Medical

College Qatar, Qatar

PB191 Hypoxic mediated signalling in vein graft failure and vascular remodelling

M. Huq, S. Currie, P. Coats

University of Strathclyde, UK

PB192 The expression of pannexins in porcine splenic arteries

A. H. Habib, W. R. Dunn, V. Ralevic

Nottingham University, UK

PB193 The Renin- Angiotensin System in preeclampsia- stydu of Angiotensin I

metabolism in human placenta

B. Bujak-Giżycka, D. Stettner, A. Wiśniewska, R. Olszanecki

Jagiellonian University Medical College, Poland

PB194 Effects of alpha lipoic acid on the endothelial progenitor cells in 5/6

nephrectomized rats

D. D. Chen, P. Y. Zhang, T. L. Cao

China Pharmaceutical University, China

PB195 Metabolic disorders and brain oxidative stress in aging: A crucial role of

Nox2-derived reactive oxygen species

L. Geng, J. Li

University of Reading, UK

PB196 Protein expression differences in hypertrophic cardiomyopathy transgenic

mice

M. Shah, R. M. Abraham

John Hopkins University, USA

PB197 Hypoxia has a role in regulating proliferation in pulmonary vascular cells

and vascular remodelling

A. Burzangi, R. Plevin, P. Coats

University of Strathclyde, UK

PB198 Oxidative stress and nadph oxidase activity in the pathophysiology of

metabolic syndrome

S. Alsufyani. University of Reading, UK

PB199 Effect of azardirachta indica on isoproterenol-induced cardiotoxicity in

wistar rats

A. F. Yusuf, T. O. Omobowale, A. A. Oyagbemi 1University of Ibadan, Nigeria

PB200 The role of G-protein-coupled receptor 55 (GPR55) in atherosclerosis-

induced cardiovascular remodelling and dysfunction

S. K. Walsh1, O. J. Robertson-Gray1, A. Jonsson-Rylander2, E. Ryberg2, C. L.

Wainwright1 1Robert Gordon University, UK, 2AstraZeneca R&D, Sweden

PB201 Hydrogen sulphide generation in the heart

Y. Y. Al-Taie, M. Garle, R. Roberts, S. Alexander

The University of Nottingham, UK

PB202 Effects of hydrogen sulphide on human chorionic blood vessels

Y. Erfaida, L. Leach, W. Dunn

The University of Nottingham, UK

PB204 Effects of the new ultra-long-acting beta2-AR agonist indacaterol in

chronic treatment alone or in combination with the beta1-AR blocker

metoprolol on cardiac remodelling

G. Gritti1, M. Donniacuo1, L. Sodano1, E. Martuscelli2, A. Orlandi2, C.

Rafaniello1, F. Rossi1, L. Calzetta2, A. Capuano1, M. Matera1, B. Rinaldi1 1Second University of Naples, Italy, 2University of Rome "Tor Vergata", Italy

PB205 Effects of rolipram on the renal microcirculation during sepsis in the rat

pup

A. M. Shahare, C. R. Sims, P. R. Mayeux.

University of Arkansas for Medical Sciences, USA

PB206 Early exposure to electrophilic ambient pollutant causes vascular and

cardiac changes by activating transient receptor potential channels

A. G. Soares1, J. Florenzano1, L. Rodrigues1, S. A. Teixeira1, S. D. Brain2, M. N.

Muscará1, S. K. Costa1. 1ICB/USP, Brazil, 2King's College London, UK

PB207 Effects of genistein on inflammatory responses in cigarette smoke-

exposed rats

P. Zhang, J. Mak, R. MAN, S. LEUNG

The University of Hong Kong, Hong Kong

PB208 Comparison of the direct and indirect vascular actions phenylephrine and

pseudoephedrine, as orally-active nasal decongestants, with reference to

plasma concentrations found in man

A. Abdulrahman1, H. Denfria1, J. Heer1, R. Mahajan2, V. Wilson1


PB209 Comparison of nitric oxide scavengers and synthesis inhibition on β-

phenylethylamine- and phenylephrine-induced vasoconstriction of

guinea-pig aorta

K. J. Broadley, H. D. Broadley

Cardiff University, UK

PB210 Pharmacological evidence that alpha2A-, alpha2B- and alpha2C-adrenoceptor

subtypes inhibit the cardioaccelerator sympathetic outflow in diabetic

pithed rats

E. Rivera-Mancilla, A. H. Altamirano-Espinoza, G. Manrique-Maldonado, B.

Villanueva-Castillo, C. M. Villalón

Cinvestav-Coapa, Mexico

PB211 Effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on rat corpus

cavernosum erectile function

G. Ünlü, S. Yıldırım, Z. Aktuna

Kirikkale University, Turkey

PB212 NO-cGMP-mediated relaxation is impaired in mesenteric arteries from

rats with periodontitis

F. Neto de Jesus, S. A. Teixeira, M. Napolitano, S. K. Costa, M. N. Muscara

University of Sao Paulo, Brazil

14:45 - 16:15

- Toxicology

PB214 Cichorium intybus attenuates streptozotocin induced diabetic

cardiomyopathy via inhibition of oxidative stress and inflammatory

response in rats

D. Ahmed1, M. Sharma2, A. Afaque2, S. Dwivedi2, Z. S. Jairajpuri2, Y. Shamsi2 1SHIATS-Deemed University, India, 2Jamia Hamdard University, India

PB215 Cytoprotective potentials of Tridax procumbens in Wistar rats'

experimental model

E. S. Samuel, J. O. Olopade, M. A. Gbadegesin, O. A. Odunola

University of Ibadan, Nigeria

PB216 The mitigating effect of Mangifera indica L. leaf extract against sodium

arsenite induced toxicities

O.E. Ola-Davies, S. S. Olawuwo

University of Ibadan, Nigeria

PB217 Real-time measurement of small molecules in awake, ambulatory subjects

P. Vieira1, N. Arroyo-Currás2, T. Kippin2, K. Plaxco2 1California State University, USA, 2University of California, USA

PB218 Effect of mosquito coil smoke on total cholesterol, glucose and

triglyceride levels in male wistar rats.

O. K. OKORO, E. Obi

Nnamdi Azikiwe University, Nigeria

PB219 Transformation of monocytes to macrophages by combination

antiretroviral treatment

C. Mafuva, W. A. Morgan

University of East London, UK

PB220 Chronic vanadium neurotoxicity: synthetic and natural product iron

chelator protection in vitro

S. Ohiomokhare1, A. Ladagu2, L. Hellwig1, J. Jennings1, J. Olopade2, P. L.

Chazot1 1Durham University, UK, 2University of Ibadan, Nigeria

PB221 Reversibility of subacute cigarette smoke exposure toxicity on testicular

and hepatic functions in whistar albino rats

J. S. Aprioku1, T. C. Ugwu

University of Port Harcourt, Nigeria

PB222 Toxicokinetics of permethrin in adult and juvenile sprague-dawley rats as

a function of age, dose and isomer

T. Mortuza, C. White, J. V. Bruckner

University of Georgia, Greece

14:45 - 16:15

- Drug Discovery, Development and Evaluation

PB223 Effect of antiarrhythmic drugs on small conductance calcium-activated

potassium channel

R. Simó Vicens1,2, D. R. Sauter1,2, M. Grunnet2,3, J. G. Diness1,2, B. H.

Bentzen1,2 1University of Copenhagen, Denmark, 2Acesion Pharma, Denmark, 3Lundbeck Pharma A/S, Denmark

PB080 TRPM3 is inhibited by activation of Gi-protein coupled receptors

T. Quallo, C. Gentry, D. A. Andersson, S. Bevan.


PB227 The impact of biochemical assay design on hit identification

N. Carter, C. McWhirter, E. Hampson, P. Akins

AstraZeneca, UK

PB228 Platyphyllenone reduces pro-inflammatory cytokine production and

attenuates malaria pathogenesis

A. Saxena1, D. Yadav1, H. S. Cheema1, M. M. Gupta1, M. P. Darokar1, D. U.

Bawankule1 1Molecular CSIR-CIMAP, India

PB229 Doxofylline exhibits steroid sparing effects in a model of allergic lung

inflammation in mice

R. Venkatasamy, Y. Riffo-Vasquez, C. P. Page


PB230 Antipyresis and the inhibition of mitochondrial function

B. M. Elegunde, S. Bashir, W. Morgan

University of East London, UK

PB231 N-(2-hydroxyphenyl)-Acetamide improves adjuvant-induced arthritis by

suppressing exaggerated levels of proinflammatory cytokines and toll-like

receptors (TLR-2 AND TLR-4)

S. U. Simjee, H. Jawed, K. Perveen

International Center for Chemical and Biological Sciences, Pakistan

PB232 Discovery of novel allosteric and selective inhibitors of inorganic

pyrophosphatase from Mycobacterium tuberculosis

A. H. Pang1, A. Garzan1, M. J. Larsen2, T. J. McQuade2, S. Garneau-

Tsodikova1, O. V. Tsodikov1 1University of Kentucky, USA, 2University of Michigan, USA

PB233 Role of cAMP-PDE inhibitors and nitric oxide modulators in

experimentally induced rheumatoid arthritis in rats

R. Pal1, M. J. Chaudhary2, P. C. Tiwari1, R. Nath1, S. Babu1, K. K. Pant1 1King George's Medical University, India, 2Government Medical College,

India

PB234 High content biochemical screening: Using big computing to screen for

novel mechanisms on the first pass

M. A. Redhead1, A. MacPherson1, R. Satchel2, J. Delgado1, S. Pollack2, P.

Foerch1 1UCB Pharma, UK, 2Sygnature Discovery, UK

PB236 Small-molecule inhibitors of urea transporters as novel diuretics

B. Yang

Peking University, China

PB237 Phenotype screening identifies vitamin D to regulate ocular

developmental angiogenesis in vivo

B. N. Kennedy, S. Merrigan

University College Dublin, Ireland

PB238 Investigation of novel antibiotic enhancer HT0120093 to enhance the

activity of colistin against multi-drug resistant New Delhi Metallo-beta-

lactamase (NDM-1) Enterobacteriaceae

S. Le, Y. Liu, A. Coates, Y. Hu

King's college London, UK

PB239 The effect of Baracitinib on murine renal fibrosis induced by unilateral

ureteral obstruction

V. Merezhko, F. Johnson, G. Purvis, W. Hull, C. Thiemermann


PB240 Trans-scleral delivery of novel small molecule inhibitors of SRPK1 inhibits

choroidal neovascularization through modulation of VEGF-A splicing

J. Batson1, J. Daubney1, H. Toop2, J. Morris3, D. Bates4 1Exonate Ltd, UK, 2University of New South Wales, Australia, 3Exonate Ltd

and University of New South Wales, Australia, 4Exonate Ltd and University

of Nottingham, UK

PB241 Anti-cancer effect of cyclopamine on Human SW-620 colorectal cancer

cells

S. Manmuan

Burapha University, Thailand

PB242 The role of mecillinam pharmacokinetics in the ability to treat resistant E.

coli infections in the neutropenic mouse thigh infection model.

A. Jewell1, E. J. Growcott2, A. K. Jones2, X. Shen2, D. Barkan2, C. R. Dean2, F.

Reck2, C. S. Osborne2 1King College, UK, 2Novartis Institutes for BioMedical Research Inc, USA

PB243 Wound healing and hydroxyproline evaluation of n-heptadecane and

octacosane on type 1 and 2 stz-induced diabetes rats.

P. N. Okechukwu

UCSI University, Malaysia

PB244 Synthesis and testing of potential CYP2A6 inhibitors

J. T. Brooks, T. T. Denton

Washington State University, USA

PB245 Modulating PAR2 signalling by novel compounds based on GB88

T. Saeed, K. McIntosh, R. Plevin

Strathclyde University, UK

PB246 Assessment of tenofovir disoproxil fumarate stability in the presence of

pancreatic enzymes: implications for prodrug oral absorption and

bioavailability

D. M. Moss, P. Curley, M. Siccardi, A. Owen

University of Liverpool, UK

PB247 High content biochemical screens, kinetic FRET assays with the Neonatal

Fc Receptor

A. Macpherson1, V. Patel2, M. Westwood1, S. J. Charlton3 1UCB, UK, 2Excellerate Bioscience, UK, 3University of Nottingham, UK

PB248 Screening of multiple sclerosis using human tissue chip model with

vasicine

A. Balasundaram, D. David

Sri Ramachandra Medical College & Research Institute, India

PB249 The comparison of anti-inflammatory efficacy of escin, dexamethasone

and cortisone

F. Fu, T. Wang, L. Wang, Y. Zou, M. Zhu, S. Duan, S. Wu

Yantai University, China

PB250 Rationale for drug combinations in tuberculosis

M. Muliaditan, O. Della Pasqua

University College London, UK

PB251 Preclinical study results of N-(5-chloropyridin-2-yl)-5-methyl-2-(4-(N-

methylacetimidamido) benzamido) benzamide hydrochloride (DD217) an

oral direct factor Xa inhibitor.

D. Tovbin1,2, M. Savelyeva2, D. Tarasov1,2, D. Malakhov2, N. Cerkovnikova2 1Russian Academy of Sciences,Russian Federation, 2PharmaDiall Ltd.,

Russian Federation

PB252 Pharmacodynamic effects of BIA 10-2474, a novel FAAH inhibitor and

evidence of target engagement in the mouse

M. J. Bonifácio1, C. Lopes1, N. Pires1, A. I. Loureiro1, P. Moser1, P. Soares-da-

Silva1,2 1BIAL – Portela & Cª, S.A, Portugal, 2University Porto, Portugal

PB253 Pharmacokinetics and pharmacodynamics of BIA 10-2474, a novel FAAH

inhibitor, following oral administration in the cynomolgus monkey

A. I. Loureiro1, C. Lopes1, M. J. Bonifácio1, P. Moser1, P. Soares-da-Silva1,2 1BIAL – Portela & Cª, S.A, Portugal, 2University Porto, Portugal

PB254 Metabolism of BIA 10-2474, a novel faah inhibitor, and its interaction with

cytochrome P450 enzymes

A. I. Loureiro1, C. Lopes1, M. J. Bonifácio1, P. Moser1, P. Soares-da-Silva1,2 1BIAL – Portela & Cª, S.A, Portugal, 2University Porto, Portugal

PB255 Structural and drug targeting studies of Mycobacterium tuberculosis

cholesterol oxidase P450 enzymes

C. N. Amadi1, K. J. Mclean1, C. W. Levy1, M. E. Kavanagh2, A. G. Coyne2, C.

Abell2, D. Leys1, A. W. Munro1 1The University of Manchester, UK, 2University of Cambridge, UK

PB256 Rock inhibitor fasudil suppresses growth of tumor by stimulating gene

expression and secretion of cxcl14/brak.

C. Miyamoto, Y. Maehata

Kanagawa Dental University, Japan

PB257 Scavenger of oxidative stress effective for the inhibition of angiogenesis

and tumor proliferation in human head and neck squamous cell carcinoma

cells by regulation gene expression of chemokines

Y. Maehata, C. Miyamoto, K. Tsukinoki

Kanagawa Dental University, Japan

PB258 Notoginsenoside R1 attenuates isoproterenol-induced hypertrophied

hearts of atherosclerosis-prone mice

B. Sun, J. Xiao

Peking Union Medical College, China

PB259 Paeonol protects endothelial function in endoplasmic recticulum stress-

induced oxidative stress in mice

M. R. Mustafa, W. C. Ker, Y. S. Lau, D. Murugan

University of Malaya, Malaysia

PB260 Combination of eugenol and gallic acid ameliorates diabetic nephropathy

in rats

M. S. Garud, Y. A. Kulkarni

SVKM'S NMIMS, India

PB263 Characterisation of an endogenous dopamine D1 receptor in U-2 OS cells

C. S. Green, J. C. Jerman, P. D. Wright

MRC Technology, UK

PB264 Effects of the selective MC3 agonists PG990 and PG992 on Interleukin-1

beta induced chondrocyte cell death and pro-inflammatory cytokine

release

V. C. Can1, I. C. Locke1, P. Grieco2, S. J. Getting1 1University of Westminster, UK, 2University of Naples Federico II, Italy

PB265 Management of diabetic neuropathy by Bauhinia variegata: A

phytomedicine

Y. A. Kulkarni, M. S. Garud

SVKM'S NMIMS, India

PB266 Structure-activity relationship of a novel family of cysteinyl leukotriene

receptor antagonist quinoline compounds with anti-angiogenic activity.

A. L. Reynolds1, P. Ventosa2, J. Granander1, C. Kilty1, E. Young1, C. T. Butler1,

O. Galvin1, S. Merrigan1, T. Sasore1, Y. Fernandez2, D. Gilheany1, B. N.

Kennedy1 1University College Dublin, Ireland, 2Gadea Pharmaceutical Group, Spain

PB267 A systemic peptide protects against organ injury in a rat-model of severe

haemorragic shock

N. Yamada1, L. Martin1,2, T. Schuerholz2,3, K. Brandenburg4, C.

Thiemermann1 1Queen Mary University of London, UK, 2University Hospital RWTH,

Germany, 3University of Rostock, Germany, 4Forschungszentrum, Germany

PB268 Laxative activities of extract, fractions and compound (vogelaxine) from

Anthocleista vogelii

G. O. Anyanwu1,2, C. E. Onyeneke2, K. Rauf3, N. U. Rahman3 1Bingham University, Nigeria, 2University of Benin, Nigeria, 3COMSATS

Institute of Information Technology Abbottabad, Pakistan

PB269 Determining the Antimicrobial Resistance for Mycoplasma hominis in the

UK.

O. H. Bell, B. Spiller

Cardiff University, UK

PB270 The effect of reconstitution medium on the long-term stability of

remifentanil hydrochloride mixed with propofol for simultaneous infusion

E. Henkel1, R. Vella1, K. Behan2, A. Fenning1 1Central Queensland University, Australia, 2Queensland Health, Australia

PB271 Polyunsaturated fatty acid ethanolamide activation of CB1 cannabinoid

and TRPV1 receptors

N. S. Alharthi, S. Alexander


PB272 Investigation of anticancer activity of pure CBD and pure CBG both

individually and in combination on chemo resistant ovarian carcinoma

cells

K. Sooda, G. Robinson, S. Allison, F. A. Javid

University of Huddersfield, UK

PB273 Cardiac microtissues as a model to predict cardiac toxicity

J. Pilling

AstraZeneca, UK

thursday 15 december 2016 poster session 14:45 - 16:15

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