three-drug combinations to be tested in aids
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4 VIEWS & REVIEWS
'Ibroo-drug combinations to be tested in AIDS
A study designed to investigate the ability of two different 3-drug combinations to reduce the viral load and produce a sustained increase in CD4+ cell counts in patients with mv infection is underway in the US.
The study is being conducted by the InterCompany Collaboration for AIDS Drug Development in conjunction with PAREXEL, an international contract research organisation. Patients with CD4+ cell counts between 200 and 500/mml who have not previously received antiretroviral therapy are being enrolled in the multi centre study.
The two 3-drug combinations to be tested arc: • zidovudine [Retrovir~ + zalcitabine [HIVID~
+ saquinavir" OnviraseTlol J • zidovuctine + zalcitabine + nevirapine.··
These 2 regimens will also be compared with the 2-drug combination of zidovudine + zalcitabine.
Because of the emergence of vi ral resistance with monotherapy, combinations of antiviral drugs will probably be needed to control mv infection, says Dr David Barry, chair of the Inter*Company Collaboration 's Clinical Trials Committee that designed the study protocol. ' - M~dja nJ~as~
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