theories of aging, anti aging

• 1. Dr Ling Sien Ngan Anti Aging, AestheticMedical Practitioner

2. Theories of Ageing

• Edith Cowan University

• Faculty of Communications, Health & Science

• Post Graduate Study inAndrology & Mens Health

Ee 5 December 2004 3.

• Every single day, as we age , more and more people are dying of cancer, or simply of old age

4.

• Are you doing something about it?

5. Lowel Anti Aging + Aesthetic Clinic , SS2 ,PJ 6. Mission:

• to enhance QoL

• through comprehensive & integrated

• anti aging & aesthetic healthcare services.

7. Anti Aging& Aesthetic medicalpractitioner 1. Anti Agingmedicine 2. Mens health & Andrology 5. Cosmeticsurgery 4. CosmeticDermatology 3. Holisticcomplimentarymedicine Aesthetic / ExternalAnti aging 8. 1)Anti agingmedicine

• Balanced diet

• Nutritional supplementations + antioxidants

• Detoxification( chelation, colon hydrotherapy, FIR sauna, ozoniser okamizu

• Correct, moderate exercise.

• Weight management

• Syndrome X + Mx of chronic deg dse -CDD

• Osteoporosis

• Bio identical hormones

• Occupational healthnoise , chemical

• Stress Mx: relaxationmeditation , yoga

• Chemoprevention & cancer

9. vs Wellness Industry Sickness Industry Anti Aging Medicine is Even here can still anti age ! 10. VisibleOxidation damagein action

• Free radical damage/oxidative stress, same process causing:

• -Iron torust

• - Cut appleturning brown

• -Underlying initiator of diseases,e.g.:

Pigmentation, wrinkle repairable by cream CAD Multiple sclerosis Cancer Alzheimers dementia Stroke Macular degeneration 11. Theories of Ageing

• Biologic, epidemiologic, + demographic data an attempt to identify a cause or process;

• Ageing: an extremely complex, multifactorial process;

• Different theories not mutually exclusive;

• Definition of ageing: open to various interpretations.

12. Summary of Presentation

• Life span and Life expectancy.

• Definition of Ageing.

• What causes ageing?

• Clinical approach to ageing.

13. Theories of Ageing

• Life span and Life expectancy.

• Definition of Ageing.

• What causes ageing?

• Clinical approach to ageing.

14. Life Span

• Maximum life span is the theoretic species specific, longest duration of life, excluding premature unnatural life.

• • Jeanne Calment, died July 1997 at age of 122.

Lowland gorilla: 47 yrs Horse: 35 yrs American hookworm: 15 yrs Earthworm: 6 yrs 15. Life Expectancy

• Life expectancy is the average number of additional years expected for a member of a population, regardless of cause of death.

16. Theories of Ageing

• Life span and Life expectancy.

• Definition of Ageing.

• What causes ageing?

• Clinical approach to ageing.

17. What is Ageing? 18. Ageing vs Senescence

• Senescence:

• • deteriorative processes that constitute natural causes of death.

• Ageing:

• • processes of accruing maturity with the passage of time, including...

George Martin. In: The ageing process, 1984 19. Ageing vs Senescence

• Positive aspects like:

• • - becoming wiser

• • - mellow

• • - evolution of life style

just like wine, improves as it ages but not as it senesces. 20. Stages of Lifespan

• Prenatal life

• Birth

• Postnatal life

• • neonatal

• • infancy

• • childhood

• • • early

• • • middle

• • • late

• • adolescence

• • adulthood

• • senescence

• Death

• fertilisation-10months

• birth thruweek 2

• • 3 wks - 1st birthday

• • • 2 - 6 yrs

• • • 7 - 10 yrs

• • • prepubertal

• • 6 yrs following puberty

• • 20 - 65 yrs

• • from 65 yrs

Ee 21. What is Ageing?

• A ubiquitous biologic process, characterised by a progressive, inevitable evolution and maturation until death.

Ee Susan A Gaylord, Mark E Williams. In: Geriatrics Review Syllabus, 1990 22. Theories of Ageing

• Life span and Life expectancy.

• Definition of Ageing.

• What causes ageing?

• Clinical approach to ageing.

Ee 23. Ageing Process

• primary ageing

• secondary ageing

Ee True primary ageing is an ongoing normal process. 24. Environmental hazards

• Ionising radiation?

• Pollutants?

• Chemicals

• Diet?

• Ambient temperature?

• Diseases?

Ee 25. Theories of Ageing

• The scientific study of ageing has been an odd mixture of the accumulation of mountains of dismal evidence that shows that almost anything you can think of goes wrong with age, and proposals of simplistic theories that try to explain ageing in terms of single processes, ranging from defective testicles to shortened telomeres.

Ee Brian Charlesworth, an evolutionary biologist 26. Theories of Ageing

• Research in ageing:

• • Traditional gerontologist

• • Evolutionary biologist

• 300 over theories till date!

Ee 27. Theories of Ageing

• Programmed theories the biological clocks.

• Error theories identify environmental insults.

Ee 28. Theories of Ageing

• Evolutionary

• Molecular

• Cellular

• Systemic

Ee Brian T. Weinert and Poala S. Timiras . Theories of Ageing.J Appl Physiol 95: 1706-1716, 2003. 29. Evolutionary Theories of Ageing

• Mutation accumulation

• Disposable soma

• Antagonistic pleiotropy

Ee 30. Molecular Theories of Ageing

• Gene regulation

• Codon restriction

• Error catastrophe

• Somatic mutation

• Dysdifferentiation

Ee 31. Cellular Theories of Ageing

• Cellular senescence Telomere theory

• Free radical

• Wear-and-tear

• Apoptosis

Ee 32. System Theories of Ageing

• Neuroendocrine

• Immunologic

• Rate-of-living

Ee 33. Theories of Ageing

• Biological theories

• • genotropic

• • environmental

• Psycho-social theories:

• • Disengagement

• • Exchange

• • Labelling

• • Social Stratification

• • Political economy

• • Continuity

Ee 34. Summary of Presentation

• Life span and Life expectancy.

• Definition of Ageing.

• What causes ageing?

• Clinical approach to ageing.

Ee 35. Clinical Approach to Ageing Ee True ageing vs disease states Biologic ageing vs chronologic ageing Promoting positive ageing 36. Positive Ageing: Pre-requisites

• Ageing is not denied;

• Perceptions and understanding of ageing are not disempowering;

• Differences between people are acknowledged.

Ee Mary Davies 37. ReconceptualisationofAgeing?

• Ageing exclusively characterised by declines in function & in health?

• Substantial heterogeneity?

• Existence of positive trajectories of ageing?

• Possible avoidance of age-related diseases and disabilities?

Ee 38. Mechanisms of successful ageing

• Persistence of normal function and plasticity

• Compensatory responses to restore function

• Interventions to replace deficient function

• Changing of health outcome by modifying risk profiles

• Prevention of diseases

• Strengthening of social interactions and support

Ee Bri