the eu strategy in horizon2020 to fight poverty related...

23
The EU strategy in Horizon2020 to fight poverty related diseases Meeting on EDCTP2 French Ministry of Education, Science and Innovation, Paris 30 June 2017 Line Matthiessen Acting Director Health Directorate DG Research & Innovation European Commission Brussels, Belgium

Upload: others

Post on 14-Jun-2020

4 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

The EU strategy in Horizon2020 to fight

poverty related diseases

Meeting on EDCTP2 French Ministry of Education, Science

and Innovation, Paris 30 June 2017

Line Matthiessen Acting Director

Health Directorate

DG Research & Innovation European Commission

Brussels, Belgium

Page 2: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

• The EU is the world's 2nd largest public funder of research on poverty-related and neglected infectious diseases

The involvement of the EU in research and innovation for PRND

Of the top three funders, only the EU significantly increased

funding (+20%) in 2015, due to its expanded contributions under

EDCTP2

Page 3: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Horizon 2020 (2014-2020): The EU funding instrument for PRND

Societal Challenge 1 (SC1) Health, Demographic change and Well being

EUR: 7.4 billion

Page 4: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Collaborative projects Public-private

partnership with big pharma

Public-public partnerships with EU Member States

& beyond

Blue sky research Grants for small businesses

Loans for small and big R&I companies

Knowledge triangle: Higher education,

business, R&I

The fight against PRNDs: one challenge, many instruments

GTBVP

Page 5: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

PRND research portfolio in H2020 (MSCA– ERC- SC1) EUR 269 million* (2014-2017)

HIV/AIDS 80 million€ Tuberculosis 49 million€ Malaria 40 million€ NIDs(including ebola and zika) 100 million€

Main areas covered

Basic research - host-pathogen interactions, genomics, mode of transmission, immune modulators Translational research (including early clinical trials) - developement or optimisation of novel diagnostics tools, vaccines, treatment and curative options, Epidemiological research – networks for outbreaks prepareness, infrastructures for data and samples sharing Personalised medicine - development of tools for mHealth

* Not including EDCTP2, IMI2

Page 6: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Collaborative research and Horizon challenge prizes

European and Developing Countries Clinical Trials

Partnership (EDCTP2)

Innovative Medicines Initiative

Public–Private Partnership between the European Union and the pharmaceutical industry association EFPIA

InnovFin ID loans

Main funding instruments under Societal Challenges Health for PRND research

Page 7: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Risk level

Resources required

EC funding instruments for feeding the pipeline

PUSH

PULL

Discovery,

PoC Preclinic

Clinical Phases

1-3

Upscaling

Manufacturing

Uptake Delivery

IMI

InnovFin ID

Horizon Prize

EDCTP Collaborative

research

Page 8: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Collaborative research actions for innovative solutions for PRND

Implemented by DG RTD

With option of emergency procedure w/o call for proposal

Between countries:

Multinational consortia: with at least 3 partners from 28 EU Member States (MS) or

Associated Countries (AC)

Researchers from any country in the world can participate. Low and middle income

countries are eligible for EU funding

Between different types of organizations

public & private sector: universities, research centres, patients

organisations, civil society, industry, SMEs, etc.

Between disciplines

multidisciplinary, translational research

Page 9: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

SC1: Collaborative platforms for vaccine development TB, HIV, malaria

TBVAC2020 - €18.2m Advancing novel an

promising TB vaccine candidates from discovery

to preclinical and early clinical development

MultiViVax - €5 m Development of Effective Vaccines against Multiple

Lifecycle Stages of Plasmodium vivax malaria

OptiMalVax - €20m Optimizing a deployable

high efficacy malaria vaccine

EAVI2020 - €23 Develop vaccine platform for novel preventive/therapeutic

vaccine candidates from discovery to early

clinical testing

EMI-TB - €8m Eliciting mucosal

immunity in tuberculosis

EHVA - €22.2m Develop Multidisciplinary

Vaccine Platform for prophylactic and therapeutic HIV Vaccines candidates and assays for identification of

immune correlates

Feeding the pipeline for EDCTP2

Page 10: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

A New Financial Instrument for Infectious Diseases R&D

• Jointly developed by the European Commission and European Investment Bank

• Provides loans between EUR 7.5m and EUR 75m to innovative players active in developing vaccines, drugs, medical and diagnostic devices, and research infrastructures for combatting infectious diseases

• No calls – demand-driven

• Launched 15 June 2015 in Riga during 'The First Innovative Enterprise Week'

*http://www.eib.org/products/blending/innovfin

Page 11: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

InnovFin loans signed so far…

CAVIDI (Swedish SME) €10 million loan

Allows Cavidi to develop an automated, high-throughput version of a low-cost HIV viral load testing devise validated under a FP7- project

MOBIDIAG (Finnish SME) €15 million loan

Allows to finalise and scale up manufacturing, validation and commercialisation of a diagnostic tool for Infectious Diseases

TRANSGENE (French SME) €20 million loan

Supports the development of innovative treatments for hepatitis B, tuberculosis as well as human papillomavirus-induced cancer

STAT-Diagnostica & Innovation, (Spanish SME) €20 million loan

Supports the development of a new molecular diagnostics device capable of identifying a wide range of infectious pathogens, such as meningitis, respiratory or gastro-intestinal infections.

BiondVax Pharmaceuticals Ltd. (Israeli SME) €20 million loan

Supports the development of a Universal Flu Vaccine candidate

Page 12: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Horizon Prizes

Horizon Prizes are 'challenge' prizes offering a cash reward to whoever can most effectively meet a defined challenge

The aim is to stimulate innovation and come up with solutions to problems that matter to European citizens

A technological or societal challenge is defined without defining the path how to reach it

The contestants are free to come up with the most promising and effective solution within a given deadline

The prize is awarded for the best delivered breakthrough solution in a competitive contest

Page 13: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Birth Day Prize

• Approximately 300,000 women died from preventable causes related to pregnancy and childbirth in 2013

• Maternal and perinatal conditions are the seventh contributors to the global burden of disease

Horizon Prize on reducing maternal and new-born morbidity and

mortality – the Birth Day Prize

• The prize calls for a novel solution to improve the outcome of facility-based deliveries (of a clinical, technological or managerial nature, or a combination of these)

• Developed by European Commission, Bill & Melinda Gates Foundation, and MSD for Mothers programme of Merck Sharp & Dohme Corporation

• More details: www.ec.europa.eu/horizonprize/birthday • deadline 6th September 2017. From the EC: 1 million €

Page 14: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Multi- funders initiatives on infectious diseases

http://www.glopid-r.org/

http://www.edctp.org

GTBVP

http://www.jpiamr.eu/

http://cepi.net/

Page 15: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Global Research Collaboration for Infectious Diseases Preparedness - Objectives

Facilitate exchange of information in outbreak situations

Establish a response plan and a strategic agenda for a coordinated and rapid research response

Address scientific, legal, ethical and financial challenges to a rapid response

Connect infectious disease research networks

Supports public health decision-making

Is NOT a new funding organisation

www.glopid-r.org

Page 16: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Members

Observer Status: World Health Organization (WHO)

CANADA

EUROPEAN COMMISSION

FRANCE

SOUTH AFRICA

SOUTH KOREA

AUSTRALIA

BRAZIL

SPAIN

MEXICO THAILAND

ARGENTINA

JAPAN WHO

UNITED KINGDOM

GERMANY

ITALY

NORWAY

INDIA

USA USA

AFRICA

EGYPT

Page 17: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Global collaboration of funding organisations, industry, PPPs, national governments and public and private organisations active in development of TB vaccine R&D To track and collate global TB vaccine strategies, intervention target product profiles, preferred product characteristics, and candidates in discovery, pre-clinical and clinical development Aim to develop and regularly update stage gating criteria suggested for moving TB vaccine candidates through pre-clinical and clinical stages of product development

Global TB Vaccine Partnership (GTBVP)

Page 18: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

#EUAMRaction #EUAMRaction #EUAMRaction

#EUAMRaction

Page 19: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

ONE HEALTH

Page 20: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

MAKING THE EU A BEST PRACTICE REGION ON AMR

• Better evidence and

awareness

• Better coordination and implementation of EU rules

• Better prevention and control

• Better addressing the role of the environment

• A stronger partnership against AMR and better availability of antimicrobials

BOOSTING RESEARCH, DEVELOPMENT AND

INNOVATION ON AMR

• New economic models & incentives

• Better detection and control measures

• New antimicrobials, rapid diagnostic tests, vaccines & alternative therapies

• AMR in the environment

SHAPING THE GLOBAL AGENDA ON AMR

• Stronger EU global presence, partnering

• Stronger bilateral partnership for stronger cooperation

• Cooperating with developing countries

• Developing a global research agenda

Page 21: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

Pillar 2 Boosting research, development and innovation

The Commission will:

• Improve knowledge on detection, effective infection control and surveillance

• Develop new therapeutics and alternatives

• Develop new preventive vaccines

• Develop novel diagnostics

• Develop new economic models and incentives

• Close knowledge gaps on AMR in the environment and on how to prevent transmission

• Special attention to WHO's priority list, TB, HIV, malaria and neglected infectious diseases

Page 22: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

• Improve global coordination of research activities by promoting dialogue and collaboration between international research initiatives

• Support the establishment of a virtual research institute under JPIAMR

• Continue collaborative research with sub-Saharan Africa in the context of EDCTP, in particular in relation to TB, HIV, malaria and NID

• Foster international research collaboration on AMR in the animal health sector in the STAR-IDAZ International Research Consortium

Please find here the link to the EC press release for the AMR Action Plan: http://europa.eu/rapid/press-release_IP-17-1762_en.htm

The Commission will:

DEVELOPING A GLOBAL RESEARCH AGENDA

Page 23: The EU strategy in Horizon2020 to fight poverty related ...cache.media.education.gouv.fr/file/2017/23/2/EC_H... · The EU strategy in Horizon2020 to fight poverty related diseases

THANK YOU