tgf- β receptor ii and gastric cancer
DESCRIPTION
TGF- β Receptor II and Gastric Cancer . Demi Dabor-Alloh. TGF- β Receptor II is a trans-membrane serine/threonine kinase. TGF β signalling regulates many cell processes. including : Growth Inhibition Cell Migration Invasion Epithelial – Mesenchymal Transition - PowerPoint PPT PresentationTRANSCRIPT
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DEMI DABOR-ALLOH
TGF-β Receptor II and Gastric Cancer
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TGF-β Receptor II is a trans-membrane serine/threonine kinase
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TGF β signalling regulates many cell processes
including: Growth Inhibition Cell Migration Invasion Epithelial – Mesenchymal Transition Extracellular Matrix Remodelling Immune - suppression
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Knocking out TGF-β receptor II caused embryonic lethality and defects of yolk sac haematopoiesis and
vasculogenesis
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Gastric cancer is the second most frequent cause of cancer death in the world after lung cancer.
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Some patients with gastric cancer have mutations that truncate the TGF-β RII protein
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The TGF-β Paradox: it has Cytostatic effects vs. tumour favouring effects
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Surgery is the primary treatment for gastric cancer
http://www.hopkins-gi.org
Total Gastrectomy
Endoscopic Mucosal Resection
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Works Cited
Oshima, M., Oshima, H., Taketo, M.M, 1996. TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoesis and Vasculogenesis. Developmental Biology, 179, pp297 – 302.
Yang, H.K., Kang S.H., Kim, Y.S., et al, 1999. Truncation of the TGF-β type II receptor gene results in insensitivity to TGF- β in human gastric cancer cells. Oncogene, 18, pp2213 – 2219.
Akhurst, R.J., Derynck R, 2001. TGF- β signilling in cancer – a double-edged sword. Trends in Cell Biology, 11 (11), pp44 – 49.
Bachman, K.E., Park, B.H, 2005. Duel nature of TGF- β signalling: tumor suppressor vs. tumor promoter. Current Opinion in Oncology, 17, pp49 – 54.
Akhurst, R.J., Hata, A, 2012. Targeting the TGF- β signalling pathway in disease. Nature, 11, pp790 – 807.
Narayan, S., Thangasamy, T., Balusu, R, Transforming Growth Factor – Beta Receptor Signalling in Cancer, 2005. Frontiers in Bioscience, 10, pp1135 – 1145.
Jakowlew, S, 2006. Transforming growth factor- β in cancer and metastasis. Cancer Metastasis Review, 25, pp435 – 457.
Mishra, L., Shetty, K., Tang,Y., et al, 2005. The role of TGF- β and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene, 24, pp5775 – 5789.
de Caestecker, M.P., Piek, E., Roberts, A.B, 2000. Role of Transforming Growth Factor- β Signaling in Cancer. Journal of the National Cancer Institute, 92 (1), pp388 – 402.
Becker, K.F., Keller, G, 2010. Gastric Cancer, Encyclopaedia of Life Sciences.